metaM glyb c
type: Species
constant: false
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
boundary condition: false
name: glycine betaine
is: SBO:0000247
is: HMDB00043
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_3addcf89_405e_4852_854d_3edf33d4eb7a
name: _AI990637_1_x
boundary condition: true
constant: false
is encoded by: hsa:AI990637
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR ALAt2r
type: Reaction
is described by: ECO:0000304
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-alanine reversible transport via proton symport
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaR r1648
fast: false
is: SBO:0000185
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR VALtec
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
type: Reaction
name: L-valine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
modifier: MODEL1310110044#

metaM val L e
name: L-valine
boundary condition: false
is: HMDB00883
has only substance units: false
is: CHEBI:16414
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaM aacoa m
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false
type: Species
is: HMDB01484
name: acetoacetyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57286

metaR KCC2t
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction

metaR RE1526M
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
reversible: true
product: MODEL1310110044#
name: RE1526
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaM acac e
name: acetoacetate
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
is: HMDB00060
initial amount: NaN
initial concentration: 1.0

metaM ac e
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
name: acetate
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00042
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:30089

metaM thr L e
boundary condition: false
is: CHEBI:16857
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-threonine
is: HMDB00167
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_d83bee0e_0307_44fd_8521_e01bb56549d3
is: SBO:0000252
is encoded by: hsa:5232
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: P07205
boundary condition: true
constant: false
name: PGK2

metaM bhb e
is: SBO:0000247
name: (R)-3-hydroxybutyrate
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
constant: false
is: HMDB00011
has only substance units: false
initial amount: NaN
is: CHEBI:10983
boundary condition: false

metaM dhcholoylcoa x
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
is: CHEBI:27393
type: Species
is: HMDB06895
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1

metaR r2387
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
fast: false

metaM 34dhpac c
is: CHEBI:27978
initial concentration: 1.0
is: SBO:0000247
is: HMDB03791
initial amount: NaN
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
has only substance units: false
type: Species
name: 3,4-Dihydroxyphenylacetaldehyde
constant: false
boundary condition: false

metaM cholp c
initial concentration: 1.0
is: CHEBI:295975
type: Species
boundary condition: false
constant: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
name: choline phosphate(1-)
initial amount: NaN
is: SBO:0000247

metaR r1433
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
kinetic law: MODEL1310110044#
reversible: false
product: MODEL1310110044#
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#

metaR PRO1x
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.99.8
modifier: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176
name: L-ProlineNAD+ 5-oxidoreductase

metaM dcacoa x
is: HMDB06404
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
is: CHEBI:61430
is: SBO:0000247
is: C05274
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274

metaR r1647
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SMPD4
reversible: false
is: SBO:0000176
name: sphingomyelinase
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
fast: false

metaM txa2 e
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452
name: thromboxane A2(1-)
type: Species
constant: false
has only substance units: false
is: CHEBI:57445
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_62f56b42_59ef_4fc5_a063_0e7281ed15d1
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000297
initial concentration: NaN
has part: E5KS60

metaM spmd c
is: CHEBI:57834
is: HMDB01257
is: C00315
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
boundary condition: false
has only substance units: false
type: Species
name: Spermidine
constant: false
initial concentration: 1.0

metaR GUAt
type: Reaction
modifier: MODEL1310110044#
fast: false
is: SBO:0000185
reversible: true
name: Guanine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269

metaM asp L c
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
constant: false
boundary condition: false
name: L-aspartate(1-)
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00191
is: CHEBI:29991
has only substance units: false

metaR GGH 10FTHF5GLUe
fast: false
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
reactant: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000

metaR HEX4
is: SBO:0000176
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: hexokinase (D-mannose:ATP)
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
product: MODEL1310110044#

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dGTP),nuclear
kinetic law: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110044#

metaR DNDPt25m
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
name: dTDP transport via dCDP antiport
kinetic law: MODEL1310110044#
is: SBO:0000185

metaM prostgd2 e
is: SBO:0000247
name: prostaglandin D2(1-)
boundary condition: false
is: HMDB01403
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696

metaM lac L c
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: (S)-lactate
boundary condition: false
is: HMDB00190
initial amount: NaN

metaR GRTTx
reactant: MODEL1310110044#
is: SBO:0000176
fast: false
name: geranyltranstransferase
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reversible: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134
kinetic law: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_125df715_2ad1_4e9d_a574_6f31bd72ce88
name: PDE3B
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5140
boundary condition: true
type: Species
is: Q13370
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_6d7bdcfd_c786_4367_8c88_f88af2724ab2
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P31645
name: SLC6A4
type: Species
is encoded by: hsa:6532

http://identifiers.org/biomodels.db/MODEL1310110044#_49a0d0f7_6261_49dc_aa83_8c53978681fa
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P42765
is encoded by: hsa:10449
name: ACAA2

metaR RE3628M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3628
modifier: MODEL1310110044#
reversible: true
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false

metaR CITtam
fast: false
reversible: true
modifier: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110044#
name: citrate transport, mitochondrial
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaR ILETAm
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110044#
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000176

metaR r2386
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110044#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false

metaR HXPRT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110044#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
reactant: MODEL1310110044#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR METyLATthc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_33ba9226_d26a_48f1_910b_0d275e575b2d
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is: O43306
has only substance units: false
is encoded by: hsa:112
name: ADCY6
initial concentration: NaN

metaR r1646
type: Reaction
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_56eaf3c2_509f_4bc6_b29c_55e77361b41c
has only substance units: false
constant: false
name: CH25H
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9023
is: SBO:0000252
is: O95992
type: Species

metaM ac c
boundary condition: false
is: CHEBI:30089
name: acetate
is: SBO:0000247
constant: false
is: HMDB00042
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
initial concentration: 1.0

metaM 3ddecdicoa m
is: HMDB03952
initial amount: NaN
is: SBO:0000247
constant: false
is: C05280
type: Species
boundary condition: false
has only substance units: false
name: 3,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM ala B m
boundary condition: false
is: SBO:0000247
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16958
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_db04430b_3a5f_4def_8696_55e059fd327c
is: O43868
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: SLC28A2
initial concentration: NaN
type: Species
is encoded by: hsa:9153

metaM glyald m
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17378
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01051
name: D-glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaR PPCDC
product: MODEL1310110044#
is described by: ECO:0000269
reactant: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
name: phosphopantothenoylcysteine decarboxylase
reversible: false

metaM thr L c
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
type: Species
initial concentration: 1.0
name: L-threonine
constant: false
is: SBO:0000247
is: HMDB00167
initial amount: NaN
has only substance units: false
boundary condition: false

metaM leuktrD4 c
is: HMDB03080
initial concentration: 1.0
boundary condition: false
type: Species
name: Leukotriene D4
is: CHEBI:28666
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN

metaM 13 cis oretn n
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01311
initial amount: NaN
is: SBO:0000247
type: Species
name: 13-cis-oxo-retinoic acid
notes: FORMULA: C20H27O3 CHARGE: -1
is: CHEBI:16004

metaR r2389
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110044#
fast: false

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_6dffd953_241a_4555_9f58_36ae026452c1
initial concentration: NaN
is: Q9BRC7
boundary condition: true
initial amount: NaN
name: PLCD4
constant: false
type: Species
is encoded by: hsa:84812
has only substance units: false
is: SBO:0000252

metaR r1645
modifier: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR RPEc
fast: false
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
type: Reaction
product: MODEL1310110044#
name: ribulose 5-phosphate 3-epimerase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2

metaM txa2 c
name: thromboxane A2(1-)
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01452
boundary condition: false
is: CHEBI:57445
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

metaM pa hs g
initial amount: NaN
has only substance units: false
is: CHEBI:57739
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: SBO:0000247
constant: false
boundary condition: false
name: phosphatidate(2-)
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_b9354e69_9f93_486c_bc50_6699a06984bf
constant: false
is: A8MYF6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6307
name: MSMO1

metaM lys L x
is: HMDB00182
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR GMPR
product: MODEL1310110044#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
kinetic law: MODEL1310110044#
name: GMP reductase
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.7.1.7
is described by: ECO:0000269

metaM Ssq23epx r
constant: false
type: Species
is: HMDB01188
name: (S)-2,3-epoxysqualene
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15441

metaR BTNt2
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
modifier: MODEL1310110044#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110044#
name: Biotin reversible transport via proton symport
fast: false
is: SBO:0000185

metaM lac L e
is: CHEBI:16651
type: Species
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
has only substance units: false
is: HMDB00190
name: (S)-lactate
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM asp L e
constant: false
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
is: SBO:0000247
name: L-aspartate(1-)
type: Species
is: HMDB00191
is: CHEBI:29991
initial concentration: 1.0
initial amount: NaN

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
is: SBO:0000176
reactant: MODEL1310110044#
fast: false
name: RE3421
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR SERGLYexR
fast: false
is described by: ECO:0000304
name: L-Serine/Glycine reversible exchange
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction

metaM ribflv c
type: Species
is: CHEBI:3554
is: HMDB00244
has only substance units: false
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: SBO:0000247
boundary condition: false
name: Riboflavin
initial amount: NaN
initial concentration: 1.0
is: C00255

metaR r1431
kinetic law: MODEL1310110044#
is: SBO:0000176
reversible: false
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000

metaR r2388
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110044#
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaR r0400
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000176
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_4d247535_6765_42ef_a433_117d7a05c8d1
name: HSD3B2
constant: false
is: P26439
initial amount: NaN
is encoded by: hsa:3284
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_bcd17bb9_e954_4a33_b73b_eb2bee96015a
has only substance units: false
is encoded by: hsa:51292
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: GMPR2
is: Q9P2T1
is: SBO:0000252
initial amount: NaN

metaR TPI
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
modifier: MODEL1310110044#
name: triose-phosphate isomerase
kinetic law: MODEL1310110044#
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.1
is described by: ECO:0000134
product: MODEL1310110044#

metaM mmcoa R m
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57326
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01269
boundary condition: false
name: (R)-methylmalonyl-CoA(5-)
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721

metaM taur x
is: SBO:0000247
type: Species
is: CHEBI:15891
constant: false
is: HMDB00251
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
has only substance units: false
name: taurine
initial concentration: 1.0

metaR r1644
reversible: true
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_79d204b0_9c08_43f6_b1d2_2cd56c86721b
is encoded by: hsa:8898
constant: false
is: A6NN98
is: SBO:0000252
name: MTMR2
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a08667c3_447c_48a6_80a0_86a5ac693b06
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DGKD
is: SBO:0000252
is encoded by: hsa:8527

metaR r1583
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_91200f8d_9f7f_48fa_8ee9_cde982731592
name: FTCD
has only substance units: false
is encoded by: hsa:10841
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaM leuktrD4 e
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
initial concentration: 1.0
constant: false
boundary condition: false
name: Leukotriene D4
is: HMDB03080
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_9a31f68c_5020_4803_992e_3b59670e2f67
boundary condition: true
is encoded by: hsa:2878
initial concentration: NaN
name: GPX3
initial amount: NaN
type: Species
is: P22352
has only substance units: false
constant: false
is: SBO:0000252

metaR r2064
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110044#

metaR FAOXC226C205m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaR r2321
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR NDPK2n
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#
reversible: true

metaR DPMVDx
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.1.1.33
reactant: MODEL1310110044#
name: diphosphomevalonate decarboxylase
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110044#

metaM octa c
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
is: C06423
is: HMDB00482
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:25646
name: octanoate (n-C8:0)
has only substance units: false

metaM tdcoa x
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false
boundary condition: false
is: HMDB01521
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
is: SBO:0000247
is: C02593
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_73d73998_a20c_4007_aa70_319ad42af545
is: SBO:0000252
type: Species
is encoded by: hsa:60386
initial concentration: NaN
has only substance units: false
is: Q9HC21
initial amount: NaN
constant: false
name: SLC25A19
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_5ca59a00_4d87_4bc3_a1aa_81ad41698468
constant: false
is: SBO:0000252
is encoded by: hsa:343
name: AQP8
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: O94778

metaR r1643
is: SBO:0000185
modifier: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM g3p c
is: SBO:0000247
type: Species
is: CHEBI:58027
has only substance units: false
name: Glyceraldehyde 3-phosphate
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
is: C00661
is: HMDB01112
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116

http://identifiers.org/biomodels.db/MODEL1310110044#_ec95b40a_07b5_41d5_8e22_30c5bbbb625b
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:H77542
initial amount: NaN
name: _H77542_1_r

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM ppcoa c
boundary condition: false
initial concentration: 1.0
name: Propanoyl-CoA
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
type: Species
is: HMDB01275
initial amount: NaN
is: CHEBI:57392

metaM ribflv e
name: Riboflavin
boundary condition: false
is: CHEBI:3554
initial concentration: 1.0
is: HMDB00244
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
is: C00255

metaR r2320
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110044#
type: Reaction

metaR HEX1
is described by: ECO:0000134
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaR ATP2ter
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: AMP/ATP transporter, endoplasmic reticulum
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_469f4237_4a48_4d79_83b1_15b5d9e8f020
boundary condition: true
initial amount: NaN
name: ACP6
has only substance units: false
is: Q9NPH0
is encoded by: hsa:51205
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r1642
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM ahcys r
constant: false
is: CHEBI:16680
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
name: S-adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.22
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0278cd77_8154_4f65_a10d_417e3389b76f
type: Species
name: SLC5A2
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6524
is: SBO:0000252
boundary condition: true
is: P31639

http://identifiers.org/biomodels.db/MODEL1310110044#_0e3980e3_db7e_4209_9e4a_e522dde1c893
constant: false
is encoded by: hsa:686
is: SBO:0000252
is: P43251
name: BTD
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_14a99c30_b2e6_40c0_8cbe_f651ea1c9676
type: Species
is encoded by: hsa:160728
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC5A8
initial concentration: NaN
initial amount: NaN
is: Q8N695
constant: false

metaM bhb c
constant: false
type: Species
name: (R)-3-hydroxybutyrate
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:10983
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

metaR r1581
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
type: Reaction

metaM HC00319 m
is: CHEBI:30794
boundary condition: false
initial amount: NaN
constant: false
name: Malonate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

http://identifiers.org/biomodels.db/MODEL1310110044#_3c872529_eeb7_4ea6_a9bb_308525d8060b
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PDE8A
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5151

metaM 3hibutcoa m
is: CHEBI:28259
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
type: Species
is: HMDB01052
has only substance units: false
name: (S)-3-Hydroxyisobutyryl-CoA
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

metaM acac c
initial amount: NaN
type: Species
is: HMDB00060
name: acetoacetate
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR r2066
product: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110044#
reversible: false

metaM prostgd2 c
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57406
name: prostaglandin D2(1-)

http://identifiers.org/biomodels.db/MODEL1310110044#_38cbb6df_3ba7_44a5_a89a_10bd6eb93662
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:10050
boundary condition: true
is: Q9Y2C5
initial concentration: NaN
has only substance units: false
name: SLC17A4
initial amount: NaN

metaR NDPK2m
kinetic law: MODEL1310110044#
reversible: true
is: SBO:0000176
modifier: MODEL1310110044#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
product: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
type: Reaction

metaM spmd e
initial amount: NaN
initial concentration: 1.0
is: C00315
is: SBO:0000247
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
has only substance units: false
boundary condition: false
name: Spermidine
is: HMDB01257
is: CHEBI:57834

http://identifiers.org/biomodels.db/MODEL1310110044#_fea04305_f530_4891_b2e9_47e8ee016f85
name: ATG9B
boundary condition: true
is: Q674R7
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:285973
constant: false
has only substance units: false
is: SBO:0000252

metaM CE4794 m
is: CHEBI:57923
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: cis-6-dodecenoyl-CoA
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_2fcc8c3a_ae64_4207_b695_0b6c9a52bc70
is: SBO:0000252
is encoded by: hsa:6713
name: SQLE
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: Q5HYI4

metaR GAMt1r
product: MODEL1310110044#
reversible: true
fast: false
name: glucosamine transport (uniport)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269

metaR r1641
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#

metaM nadph x
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00221
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: SBO:0000247

metaR RETHe
is: SBO:0000176
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
fast: false
name: retinyl ester hydrolase, extracellular
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
is described by: ECO:0000000

metaR r1580
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

metaM zymst r
name: zymosterol
is: CHEBI:18252
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial amount: NaN
has only substance units: false
is: HMDB06271
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM 3hbcoa m
constant: false
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
is: CHEBI:57316
type: Species
is: HMDB01166
boundary condition: false
is: SBO:0000247
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN

metaM ctp n
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00082
constant: false
name: CTP(4-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_63a25756_802f_454e_9a5a_ca96afaf08d5
is: P40394
constant: false
has only substance units: false
boundary condition: true
name: ADH7
type: Species
initial amount: NaN
is encoded by: hsa:131
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_2c4bb85c_db0f_42cf_93e6_01de31c194c1
constant: false
name: CA5B
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11238
boundary condition: true
is: Q9Y2D0
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_fb78398b_f83a_411f_92ca_de32ae2b02ed
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:8659
initial concentration: NaN
type: Species
name: ALDH4A1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_2b76e7c6_172a_416c_a0b3_7965d66980bd
is: SBO:0000252
is encoded by: hsa:PRO1933
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: _PRO1933_1_m
boundary condition: true
type: Species

metaM creat e
constant: false
is: SBO:0000247
is: HMDB00064
initial concentration: 1.0
is: CHEBI:16919
boundary condition: false
name: creatine
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

http://identifiers.org/biomodels.db/MODEL1310110044#_f9794430_a3c1_468f_888d_845a2304bad1
boundary condition: true
has only substance units: false
name: SLC25A16
is: SBO:0000252
type: Species
is: P16260
initial concentration: NaN
constant: false
is encoded by: hsa:8034
initial amount: NaN

metaM tdcoa m
has only substance units: false
is: C02593
is: HMDB01521
constant: false
is: CHEBI:57385
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_6e441412_b640_46c9_8704_57b6231a491e
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9ULD0
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:55753
initial amount: NaN
name: OGDHL

metaM ac m
name: acetate
is: CHEBI:30089
initial amount: NaN
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00042

metaM gam6p c
constant: false
name: D-Glucosamine 6-phosphate
initial amount: NaN
is: CHEBI:12962
type: Species
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: HMDB01254
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR NADPtru
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110044#
reversible: false
name: NADP transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction

metaM so3 m
is: CHEBI:17137
has only substance units: false
initial amount: NaN
is: HMDB00240
name: hydrogensulfite
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaM 13 cis oretn c
name: 13-cis-oxo-retinoic acid
is: SBO:0000247
is: CHEBI:35291
constant: false
initial amount: NaN
notes: FORMULA: C20H27O3 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: HMDB01852
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_41af289b_6bc0_40d0_9873_0831344dd856
has only substance units: false
constant: false
name: NUDT12
boundary condition: true
is: Q9BQG2
initial concentration: NaN
type: Species
is encoded by: hsa:83594
is: SBO:0000252
initial amount: NaN

metaR r1587
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 2hb c
name: 2-Hydroxybutyrate
is: HMDB00008
is: CHEBI:1148
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

metaR r0557
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
reversible: false
kinetic law: MODEL1310110044#

metaR r2325
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaM dhap x
constant: false
initial concentration: 1.0
is: C00111
is: CHEBI:57642
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
type: Species
name: Dihydroxyacetone phosphate
is: HMDB01473
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_8d723bd9_1b3f_48e0_ac7a_6784a9964ae0
is: SBO:0000252
is: P09917
has only substance units: false
name: ALOX5
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:240
boundary condition: true

metaR DM dttp m
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a304597b_132f_4214_b41c_be0231e1056c
is encoded by: hsa:23761
is: Q9UG56
initial amount: NaN
initial concentration: NaN
name: PISD
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR r1586
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000

metaR r0629
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.1.22
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110044#

metaR FAOXC185m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_227d04eb_7fdf_4dd7_99ab_06ecf854df8a
is: O15254
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:8310
type: Species
name: ACOX3

http://identifiers.org/biomodels.db/MODEL1310110044#_84fe7d2d_93d4_4a3d_9ac7_99bd92e2ce9e
initial amount: NaN
type: Species
is encoded by: hsa:23428
has only substance units: false
is: Q9UHI5
initial concentration: NaN
name: SLC7A8
boundary condition: true
constant: false
is: SBO:0000252

metaR r0403
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000176
reversible: true
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
fast: false
is described by: ECO:0000000
product: MODEL1310110044#

metaM HC01104 e
is: SBO:0000247
name: 4-nitrophenyl phosphate(2-)
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: CHEBI:61146
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r0556
modifier: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_62895608_8886_4a75_8cdd_fa5eaf541fdb
name: PDE2A
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q8IW54
constant: false
has only substance units: false
is encoded by: hsa:5138
type: Species
is: SBO:0000252

metaR r2324
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR SGPL12r
reversible: false
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
type: Reaction
name: Sphingosine-1-phosphate lyase
reactant: MODEL1310110044#
is described by: ECO:0000304
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110044#
is: SBO:0000176

metaM aacoa x
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: HMDB01484
is: SBO:0000247
boundary condition: false
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
initial concentration: 1.0

metaR r0781
reversible: true
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial concentration: 1.0
is: HMDB00064
type: Species
is: CHEBI:16919
name: creatine
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_f3b9357e_f44b_4656_9d20_0f90ca629564
initial amount: NaN
type: Species
is encoded by: hsa:AI090874
has only substance units: false
name: _AI090874_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_bf2f74e1_2d59_4ab2_a3ff_9b88b7bbdd18
has only substance units: false
type: Species
is encoded by: hsa:491
boundary condition: true
constant: false
is: Q4J699
initial concentration: NaN
name: ATP2B2
is: SBO:0000252
initial amount: NaN

metaR r2323
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1585
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_241b463f_026d_4109_a523_ab8b674ac1c7
type: Species
has only substance units: false
is: SBO:0000252
is: P40879
initial amount: NaN
initial concentration: NaN
name: SLC26A3
constant: false
is encoded by: hsa:1811
boundary condition: true

metaM ivcoa m
type: Species
is: HMDB01113
initial amount: NaN
constant: false
has only substance units: false
name: Isovaleryl-CoA
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57345
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false

metaM ala B e
type: Species
is: HMDB00056
constant: false
initial concentration: 1.0
is: CHEBI:16958
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_8480ba11_c8c5_44e3_8c22_7717234f1f85
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:1109
initial concentration: NaN
is: P17516
name: AKR1C4
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_9ab9d1f1_2546_4467_92eb_33a7715a9b62
initial amount: NaN
constant: false
is: O43674
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: NDUFB5
is encoded by: hsa:4711
type: Species
boundary condition: true

metaR r1862
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
reversible: false
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110044#

metaM nadph m
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
initial amount: NaN
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaM nadp m
initial concentration: 1.0
constant: false
type: Species
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
initial amount: NaN
is: CHEBI:58349
boundary condition: false
is: SBO:0000247

metaR r0559
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1

http://identifiers.org/biomodels.db/MODEL1310110044#_1f6a698b_4509_4d63_8ccf_95470f1d3ae0
type: Species
constant: false
has only substance units: false
name: SLC24A4
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:123041

metaR r0780
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#

metaR r2322
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR RE1342C
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
type: Reaction
name: RE1342
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110044#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_62186197_2ddf_4435_ba35_ef8662af2963
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:56953
constant: false
initial amount: NaN
name: NT5M
is: Q9NPB1
type: Species

metaM ser L m
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17115
name: L-serine
has only substance units: false
boundary condition: false
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

http://identifiers.org/biomodels.db/MODEL1310110044#_9563fa4a_51ae_4fa1_a12a_32483934423e
initial concentration: NaN
type: Species
is encoded by: hsa:4830
is encoded by: hsa:4831
has part: P22392
has part: P15531
name: NME1:NME2
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000297
boundary condition: true

metaR r1584
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e8fea456_af7a_464d_950b_fc23f667dd25
is encoded by: hsa:9123
is: O15427
name: SLC16A3
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaR COAtr
is: SBO:0000185
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110044#

metaR r1302
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Vesicular transport
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
type: Reaction

metaM glu L c
has only substance units: false
name: L-glutamate(1-)
is: HMDB00148
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
constant: false
initial concentration: 1.0

metaR NCNt
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110044#
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM octa e
boundary condition: false
is: SBO:0000247
is: C06423
has only substance units: false
name: octanoate (n-C8:0)
is: HMDB00482
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:25646
notes: FORMULA: C8H15O2 CHARGE: -1

metaR CYTK14n
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR r0558
type: Reaction
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110044#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is described by: ECO:0000000

metaR RETNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
name: retinoic acid transport
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_4a4745d0_3a9c_4812_a263_cfd0712100b6
constant: false
boundary condition: true
has only substance units: false
name: _R06874_1_r
is encoded by: hsa:R06874
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR TYRt
product: MODEL1310110044#
is described by: ECO:0000269
name: L-tyrosine transport
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: true
modifier: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction

metaM txa2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
is: HMDB01452
is: CHEBI:57445
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: thromboxane A2(1-)

http://identifiers.org/biomodels.db/MODEL1310110044#_f8f51c3d_d8ce_4868_90d9_705fa206ec5f
initial concentration: NaN
initial amount: NaN
is: P37268
is encoded by: hsa:2222
name: FDFT1
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR DESAT22 1p
fast: false
reversible: false
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_348c9d13_08dd_47b3_8041_ea33e330215d
is: Q13232
initial amount: NaN
initial concentration: NaN
name: NME3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4832
type: Species
boundary condition: true
constant: false

metaM 3mb2coa m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01493
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
name: 3-methylbut-2-enoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57344
constant: false

metaR r2329
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110044#
is described by: ECO:0000000

metaR ILEt5m
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
type: Reaction
name: Isoleucine mitochondrial transport

metaR r0553
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110044#

metaR PACCOAL
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction
product: MODEL1310110044#
fast: false
name: phenylacetate-CoA ligase
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0e053e89_289c_440b_92d8_cf4a6834e132
boundary condition: true
initial concentration: NaN
name: PANK2
constant: false
has only substance units: false
is: SBO:0000252
is: Q9BZ23
is encoded by: hsa:80025
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_71df5666_556c_4183_8623_37f9cd84c929
boundary condition: true
initial amount: NaN
constant: false
name: GGT2
is encoded by: hsa:728441
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_8573bbaa_0d52_417c_9222_f61dbcefd120
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10861
name: SLC26A1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR r0408
modifier: MODEL1310110044#
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_49b51c14_533b_4bf5_93f7_7ee65ddae555
is: Q86XP1
name: DGKH
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:160851

metaM tyr L e
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
name: L-tyrosine
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00158

http://identifiers.org/biomodels.db/MODEL1310110044#_6bf73dd4_ba0e_44ac_8de2_607ee8750c8d
type: Species
is: P00492
boundary condition: true
constant: false
initial amount: NaN
name: HPRT1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3251

metaM retn c
constant: false
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
initial concentration: 1.0
is: SBO:0000247
name: all-trans-retinoate
has only substance units: false
is: CHEBI:35291
is: HMDB01852
boundary condition: false

metaM icit x
is: HMDB00193
is: CHEBI:16087
name: isocitrate(3-)
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_b3a50531_8a41_4da3_a06f_b33daf2f2ac5
is: P00338
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:3939
has only substance units: false
initial amount: NaN
name: LDHA

http://identifiers.org/biomodels.db/MODEL1310110044#_cfe6c732_1dc3_4d0d_a124_7c0389fd1bbd
is encoded by: hsa:54995
name: OXSM
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: Q9NWU1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_5391e213_2755_4ce3_a3d8_72b9e9971aac
boundary condition: true
name: SDHB
is encoded by: hsa:6390
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: P21912
initial concentration: NaN

metaR CHAT
name: Choline O-acetyltransferase
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_ff91b913_26db_4892_86a5_51163cd98a0b
initial concentration: NaN
name: COX5A
is encoded by: hsa:9377
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P20674
initial amount: NaN

metaR r0552
reversible: true
product: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.5.1
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaM nadph r
constant: false
has only substance units: false
is: CHEBI:57783
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00221
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_4de3ea29_1e0c_4f16_9a0b_49fe3a8c28e7
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PCBD2
is: Q9H0N5
initial amount: NaN
has only substance units: false
is encoded by: hsa:84105

metaM ocdcea r
is: HMDB00207
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00712
has only substance units: false
constant: false
name: octadecenoate (n-C18:1)
is: CHEBI:0
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0

metaM CE5118 m
initial concentration: 1.0
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
constant: false
is: SBO:0000247
type: Species
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
has only substance units: false
initial amount: NaN
boundary condition: false

metaM HC00319 c
constant: false
type: Species
is: CHEBI:30794
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: Malonate

metaR r2328
fast: false
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ctp c
constant: false
is: C00063
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP
boundary condition: false
is: SBO:0000247
is: CHEBI:37563
type: Species
initial amount: NaN
is: HMDB00082
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_442692e0_c5f8_4e25_9f2a_95468958ee8d
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:171425
name: CLYBL
is: SBO:0000252
type: Species

metaM glu L e
name: L-glutamate(1-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
type: Species
has only substance units: false
is: CHEBI:29985

metaM cholate c
name: Cholate
boundary condition: false
initial amount: NaN
is: CHEBI:29747
has only substance units: false
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00619

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110044#
is described by: ECO:0000000

metaR BALAtmr
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
reversible: true
kinetic law: MODEL1310110044#

metaM dcholcoa r
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:28701
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
name: chenodeoxycholoyl coenzyme a
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_6e99bbd6_4a9f_4227_9b96_e11fa5d1b097
name: SLC4A10
type: Species
is: B7Z1R0
initial amount: NaN
is encoded by: hsa:57282
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR RE2660C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110044#
name: RE2660
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_ac53db7d_dc1d_4141_b5f4_954aed05080b
name: ACAT1
boundary condition: true
constant: false
is encoded by: hsa:38
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P24752
type: Species
initial amount: NaN

metaM mi14p c
initial amount: NaN
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
is: HMDB00968
has only substance units: false
is: CHEBI:58282
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: SBO:0000247
boundary condition: false
constant: false

metaR C226COAtx
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r2327
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110044#

metaM oretn c
constant: false
is: CHEBI:35291
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
initial concentration: 1.0
is: HMDB01852
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: 4-oxo-retinoic acid

metaM 2hb e
constant: false
is: HMDB00008
type: Species
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:1148
has only substance units: false

metaM tyr L c
is: HMDB00158
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
name: L-tyrosine
is: CHEBI:17895
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaM val L c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: L-valine
initial amount: NaN
is: SBO:0000247
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM xol25oh r
initial concentration: 1.0
is: HMDB06247
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
name: 25-hydroxycholesterol
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:42977
constant: false

metaM hexdectecoa m
is: SBO:0000247
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR r2497
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110044#
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

metaM retn e
type: Species
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
is: CHEBI:35291
name: all-trans-retinoate
is: HMDB01852
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaR URIt5le
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: uridine transport in via sodium symport (1:2)
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM dha e
is: HMDB01882
constant: false
name: glycerone
is: SBO:0000247
is: CHEBI:16016
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_466c9a5c_036e_410d_9d80_aa8c40e71c12
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: SLC7A1
constant: false
is: P30825
is encoded by: hsa:6541

http://identifiers.org/biomodels.db/MODEL1310110044#_053837eb_f7dd_4cd0_9e6c_a318c55e84b2
initial concentration: NaN
name: EHHADH
is encoded by: hsa:1962
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q9NY65
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_207f49b4_ed0e_4044_8f33_a5b773c124ed
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: B2R6S5
name: CMPK1
is encoded by: hsa:51727
type: Species
has only substance units: false
constant: false
boundary condition: true

metaR PAN4PPe
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110044#
fast: false
name: PAN4PPe
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_da98ddcf_beb4_4b12_bd54_69768b2012fe
is: SBO:0000252
name: _22305_1_c
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:22305
initial amount: NaN
constant: false

metaR r2326
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaM bhb m
is: HMDB00011
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
type: Species
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM ctp e
constant: false
is: SBO:0000247
is: CHEBI:37563
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
name: CTP(4-)

metaM HC01231 c
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_8db1ef8c_8d34_4515_b337_f0ec793ef985
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1376
is: P23786
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: CPT2

metaM nadp r
initial amount: NaN
is: CHEBI:58349
initial concentration: 1.0
is: HMDB00217
is: SBO:0000247
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
constant: false
boundary condition: false
is: C00006
name: Nicotinamide adenine dinucleotide phosphate

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR r1588
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
fast: false

metaR r1649
reversible: true
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_84676632_d84a_44be_850f_03dfb3b1fa3c
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:8879
is: O95470
initial concentration: NaN
name: SGPL1
boundary condition: true

metaM 10fthf e
is: CHEBI:57454
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 10-formyltetrahydrofolate(2-)
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
boundary condition: false

metaR PROSTGI2t
product: MODEL1310110044#
name: Prostaglandin I2 transport
is described by: ECO:0000269
kinetic law: MODEL1310110044#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_02ca45fa_54e2_4ce3_9fde_04522d78624e
is encoded by: hsa:56606
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9NRM0
initial amount: NaN
name: SLC2A9
constant: false
has only substance units: false
type: Species

metaR SPMTDe
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110044#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
name: SPMTDe
is: SBO:0000185

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r0774
reactant: MODEL1310110044#
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110044#

metaR HYXNt
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reactant: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
name: Hypoxanthine transport
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#

metaR HMGLm
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
reactant: MODEL1310110044#
reversible: false
product: MODEL1310110044#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
kinetic law: MODEL1310110044#
type: Reaction
name: hydroxymethylglutaryl-CoA lyase
is described by: ECO:0000134
modifier: MODEL1310110044#

metaR r0560
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reversible: false
product: MODEL1310110044#
fast: false

metaR r0911
name: Facilitated diffusion
reactant: MODEL1310110044#
reversible: true
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_cbe22f33_d84f_44ca_bef1_c2c88305bc50
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:7108
is: O76062
initial concentration: NaN
is: SBO:0000252
name: TM7SF2

http://identifiers.org/biomodels.db/MODEL1310110044#_7f966ccf_a164_4e59_bf73_47aee1f9e5cf
initial amount: NaN
boundary condition: true
is encoded by: hsa:6120
is: Q53TV9
name: RPE
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaM datp c
has only substance units: false
is: HMDB01532
name: dATP
initial amount: NaN
is: CHEBI:61404
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial concentration: 1.0
is: SBO:0000247
is: C00131
constant: false
type: Species

metaR RETI1
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reactant: MODEL1310110044#
reversible: true
name: retinol isomerase (11-cis)
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction

metaR RTOTALt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110044#
reversible: true
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: RTOTAL transport
type: Reaction
kinetic law: MODEL1310110044#

metaM urcan c
is: CHEBI:17771
type: Species
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
boundary condition: false
is: HMDB00301
is: SBO:0000247
name: Urocanate
constant: false
has only substance units: false
is: C00785
initial concentration: 1.0
initial amount: NaN

metaM dpcoa c
boundary condition: false
is: C00882
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01373
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA

metaM dutp n
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
constant: false
is: HMDB01191
name: dUTP
is: SBO:0000247
initial amount: NaN
is: CHEBI:17625
type: Species
boundary condition: false

metaM 2ddecdicoa m
is: SBO:0000247
is: HMDB11123
has only substance units: false
initial concentration: 1.0
is: C05279
name: 2,6-dodecadienoylcoa
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_4e07c3f4_49ef_44d9_81d5_4182adcdd867
has only substance units: false
is: Q6IBC0
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3155
name: HMGCL

metaM damp c
is: HMDB00905
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
type: Species
name: dAMP(2-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR OCCOAtx
fast: false
name: fatty acid intracellular transport
product: MODEL1310110044#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#

metaM HC01409 m
is: CHEBI:27540
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: SBO:0000247
boundary condition: false
name: Hexanoyl-CoA

metaM Lcystin c
has only substance units: false
name: L-cystine
is: CHEBI:16283
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00192
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

metaR PRPNCOAHYDm
is described by: ECO:0000134
product: MODEL1310110044#
reversible: false
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110044#
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110044#
fast: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR PSSA1 hs
is: SBO:0000176
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29
name: Phosphatidylserine synthase homo sapiens
reversible: true
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is described by: ECO:0000269
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaM nadp x
is: SBO:0000247
type: Species
is: HMDB00217
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
has only substance units: false
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110044#_0b8a3ab4_d2aa_46b3_bb7e_a5804997b7a6
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3030
type: Species
has part: P55084
name: HADHA:HADHB
has only substance units: false
is: SBO:0000297
constant: false
is encoded by: hsa:3032
has part: E9KL44

metaM ppa e
constant: false
name: propionate
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
is: SBO:0000247

metaR r0055
is version of: http://identifiers.org/ec-code/2.4.2.8
is: SBO:0000176
modifier: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is described by: ECO:0000000
type: Reaction
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.4.2.7
reversible: true

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaM acac x
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: CHEBI:13705
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00060
is: SBO:0000247
boundary condition: false
name: acetoacetate

http://identifiers.org/biomodels.db/MODEL1310110044#_373f6b7b_8fc7_4a8b_b471_e9731f49d8c5
is: Q9HAS3
initial concentration: NaN
is encoded by: hsa:64078
type: Species
boundary condition: true
name: SLC28A3
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR UDPGLCAter
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
fast: false

metaR RETI2
reversible: true
kinetic law: MODEL1310110044#
name: retinol isomerase (9-cis)
reactant: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110044#

metaR r2318
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_2dffe5fa_9140_40f0_a4b8_db9d9f4313f3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: SLC16A2
is encoded by: hsa:6567
initial amount: NaN
constant: false
is: P36021

metaR GLUPRT
type: Reaction
reversible: false
modifier: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110044#
name: glutamine phosphoribosyldiphosphate amidotransferase
is version of: http://identifiers.org/ec-code/2.4.2.14
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110044#
fast: false

metaM pyr e
initial concentration: 1.0
has only substance units: false
name: pyruvate
constant: false
type: Species
is: SBO:0000247
is: CHEBI:15361
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
is: HMDB00243

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110044#
is described by: ECO:0000304
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#

metaM 10fthf c
name: 10-Formyltetrahydrofolate
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
is: C00234
is: CHEBI:57454
has only substance units: false
initial amount: NaN
is: HMDB00972
constant: false

metaM 9 cis retfa e
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
name: fatty acid 9-cis-retinol
is: HMDB06559
has only substance units: false
type: Species
constant: false
is: SBO:0000247

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaM dudp m
is: CHEBI:60471
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
name: dUDP(3-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01000
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_df0bc1ba_c4f0_4bdd_a1a6_6d1aecc5841a
constant: false
has only substance units: false
initial amount: NaN
is: P49189
initial concentration: NaN
name: ALDH9A1
is encoded by: hsa:223
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_1fe2d970_74a7_45da_957e_60489f08e038
has only substance units: false
initial amount: NaN
name: PPT1
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q6FGQ4
is encoded by: hsa:5538

metaR GLUDym
modifier: MODEL1310110044#
reversible: true
product: MODEL1310110044#
name: glutamate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110044#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaR r0984
is described by: ECO:0000000
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR PNTK
name: pantothenate kinase
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269

metaM HC02203 c
initial amount: NaN
boundary condition: false
name: prostaglandin-a2
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false

metaR r1726
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#
reversible: false

metaR LEUtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
reversible: true
name: L-leucine transport via diffusion (extracellular to cytosol)
product: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_657265e6_5cf8_4226_b440_a19e53e57ce3
has only substance units: false
name: CHKA
is: SBO:0000252
type: Species
is encoded by: hsa:1119
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaR ALAR
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: alanine racemase
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000212
reversible: true
type: Reaction

metaR DASPO1p
is described by: ECO:0000269
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
name: D-aspartate oxidase, peroxisomal
is version of: http://identifiers.org/ec-code/1.4.3.1
product: MODEL1310110044#
is: SBO:0000176

metaR r2319
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_6a564f42_29aa_43a3_b1c5_17c569de5084
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4645
initial concentration: NaN
constant: false
is: Q9H6Y6
name: MYO5B

metaR RE1530C
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
fast: false
name: RE1530
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_a6e4242f_5e4e_499c_8f1c_e8c19f62ad6c
boundary condition: true
initial amount: NaN
is: P36959
has only substance units: false
name: GMPR
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2766
type: Species

metaM Lcystin e
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
initial amount: NaN
is: HMDB00192
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: L-cystine

metaM hxan c
has only substance units: false
is: C00262
is: HMDB00157
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
boundary condition: false
name: Hypoxanthine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_e7d45c09_30f9_4ef5_bf58_4357de565121
boundary condition: true
constant: false
initial amount: NaN
is: Q8NB10
name: PDE1C
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5137
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_52a23f90_7518_4c67_a6b0_2a6b0a676fba
constant: false
type: Species
is: Q99714
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3028
initial amount: NaN
is: SBO:0000252
name: HSD17B10

metaM ppa c
is: HMDB00237
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
boundary condition: false
is: CHEBI:17272
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: propionate

metaM dsmsterol r
constant: false
name: desmosterol
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB02719
boundary condition: false
is: CHEBI:17737

metaM glu L m
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00148
initial concentration: 1.0
boundary condition: false
is: CHEBI:29985
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110044#_90233491_d2bd_4d50_95e2_eb8e336544ac
is: P07954
initial concentration: NaN
boundary condition: true
name: FH
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2271
constant: false

metaM pyr c
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1
type: Species
has only substance units: false
is: CHEBI:15361
is: HMDB00243
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
boundary condition: false
is: C00022

http://identifiers.org/biomodels.db/MODEL1310110044#_95bfc653_3c55_48b7_bcf3_53ea10582727
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8613
type: Species
initial concentration: NaN
name: PPAP2B
is: O14495

http://identifiers.org/biomodels.db/MODEL1310110044#_e2f5caa1_ea51_4e1c_a515_a3cd3ba148f9
type: Species
initial amount: NaN
is encoded by: hsa:159963
constant: false
boundary condition: true
is: Q1EHB4
has only substance units: false
name: SLC5A12
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_5e42d56f_07c6_42c6_9738_1750c08c20d5
is: F8VQS7
name: NDUFA12
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:55967

metaM cmpacna n
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: CHEBI:57812
type: Species
is: HMDB01176
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_1efdaa76_4d14_4e8a_bd51_18ad85920ed1
constant: false
is encoded by: hsa:23539
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC16A8
is: SBO:0000252
initial concentration: NaN
is: O95907
type: Species

metaR ARACHDt2
fast: false
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
name: fatty acid transport via diffusion
type: Reaction
reversible: true

metaM oh1 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: hydroxide ion
is: HMDB01039
notes: FORMULA: HO CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: C01328
constant: false

metaR 4HOXPACDOX NADP
product: MODEL1310110044#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
kinetic law: MODEL1310110044#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_5c67b2f8_ed15_4c6b_bc80_8de158901b98
is encoded by: hsa:F23536
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: _F23536_1_m

http://identifiers.org/biomodels.db/MODEL1310110044#_1686edf6_bbd4_4f61_b8d2_1ae5813ae638
has only substance units: false
initial amount: NaN
name: NT5C2
is encoded by: hsa:22978
type: Species
is: P49902
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_daa35990_f3c8_43b3_abc9_c0d908ea570f
is encoded by: hsa:AA854479
has only substance units: false
type: Species
name: _AA854479_1_m
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_06a2831c_4d1a_48ec_b703_b1f9eae97d04
constant: false
is: SBO:0000252
initial concentration: NaN
name: _AI222095_1_e
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI222095
has only substance units: false

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
type: Reaction
modifier: MODEL1310110044#
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.137

metaR r0915
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

metaM dcholcoa x
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
is: SBO:0000247
type: Species
is: CHEBI:28701
has only substance units: false
name: chenodeoxycholoyl coenzyme a

metaR CYSSNAT5tc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0870
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Facilitated diffusion
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.3.4
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.4.13
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_4d822ea4_0ba7_491d_a3c1_96118707d82a
constant: false
boundary condition: true
is encoded by: hsa:4729
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P19404
type: Species
initial concentration: NaN
name: NDUFV2

metaR ADEt
reversible: true
kinetic law: MODEL1310110044#
name: adenine reversible transport, cytosol
type: Reaction
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is described by: ECO:0000269

metaM doco13ac e
initial amount: NaN
has only substance units: false
name: docosenoic acid (C22:1)
is: SBO:0000247
is: HMDB02068
notes: FORMULA: C22H41O2 CHARGE: -1
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM dadp c
is: HMDB01508
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP
is: C00206
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57667
is: SBO:0000247

metaM arg L e
name: L-argininium(1+)
is: HMDB00517
is: CHEBI:32682
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r0051
product: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
kinetic law: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR PDE1
name: 3',5'-cyclic-nucleotide phosphodiesterase
reactant: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.17
is described by: ECO:0000269
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
product: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.35
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaM glyald c
is: HMDB01051
is: SBO:0000247
type: Species
constant: false
name: D-Glyceraldehyde
is: C00577
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
is: CHEBI:17378
initial amount: NaN
has only substance units: false
boundary condition: false

metaR DNDPt10m
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110044#
fast: false
reversible: false
reactant: MODEL1310110044#
is: SBO:0000185
name: dADP transport via dCDP antiport
is described by: ECO:0000269

metaM hxan e
initial amount: NaN
has only substance units: false
is: HMDB00157
is: CHEBI:17368
is: SBO:0000247
constant: false
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
type: Species
boundary condition: false

metaM stcoa c
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
constant: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114
initial amount: NaN
is: SBO:0000247
is: CHEBI:57394
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7a9809ea_f716_4f66_a137_00441106912f
initial amount: NaN
is: Q96CA6
type: Species
boundary condition: true
is encoded by: hsa:30
name: ACAA1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2848763a_6d63_4163_ab2a_ce45f2b0fb16
is encoded by: hsa:100287639
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _100287639_1_c

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
is: CHEBI:16680
boundary condition: false
is: HMDB00939
has only substance units: false
type: Species
is: C00021
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR DNDPt18m
name: dUDP transport via ADP antiport
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is: SBO:0000185
product: MODEL1310110044#

metaR SO4t4 2
reactant: MODEL1310110044#
name: sulfate transport via sodium symport
modifier: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
product: MODEL1310110044#

metaR r0627
type: Reaction
is: SBO:0000176
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000000

metaM ocdcea l
is: HMDB00207
initial amount: NaN
name: oleate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
constant: false
is: CHEBI:30823

metaM icit m
is: HMDB00193
type: Species
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false
boundary condition: false
name: Isocitrate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16087
constant: false

metaM oh1 e
name: hydroxide ion
constant: false
notes: FORMULA: HO CHARGE: -1
is: SBO:0000247
has only substance units: false
type: Species
is: C01328
boundary condition: false
is: HMDB01039
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_2fb10306_7877_4862_8bea_ee6529e88c1a
constant: false
initial concentration: NaN
has only substance units: false
name: NME2
initial amount: NaN
boundary condition: true
is encoded by: hsa:4831
is: P22392
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_b4d60c80_d459_48f3_af5a_de7a4cc9e2ff
has only substance units: false
is: Q53Y41
name: DDC
constant: false
type: Species
is encoded by: hsa:1644
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r0913
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110044#

metaM lnlccoa m
constant: false
type: Species
is: HMDB01064
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
name: linoleic coenzyme A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_64568e05_0ec7_4864_bdf4_5ca940b11044
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: P13073
initial concentration: NaN
constant: false
is encoded by: hsa:1327
name: COX4I1

http://identifiers.org/biomodels.db/MODEL1310110044#_ffe83d24_46e4_4c56_bf50_d3f47d3db130
initial concentration: NaN
name: NME1
is: SBO:0000252
constant: false
is encoded by: hsa:4830
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_7e1a62d7_68f0_4483_ae3c_61ffb1f85bba
is encoded by: hsa:8608
has only substance units: false
constant: false
name: RDH16
boundary condition: true
initial concentration: NaN
type: Species
is: O75452
is: SBO:0000252
initial amount: NaN

metaM HC00460 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:58044
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: 2,5-dihydroxybenzoate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_d146a900_1298_408d_acdd_b910418db2c2
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9016
name: SLC25A14
is: O95258
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_bc59387f_5a29_448a_809f_41c4811867b9
has only substance units: false
type: Species
name: _T83654_1_c
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:T83654
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_b23a04a6_e847_4459_86e8_1e722c2f8c0e
name: GLRX
type: Species
is encoded by: hsa:2745
is: P35754
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM dpcoa e
has only substance units: false
is: HMDB01373
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
name: Dephospho-CoA
is: SBO:0000247
constant: false
is: C00882
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57328

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM aacoa c
constant: false
is: SBO:0000247
is: HMDB01484
type: Species
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
boundary condition: false
name: Acetoacetyl-CoA
is: C00332
initial amount: NaN
is: CHEBI:57286

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
is: C05274
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
type: Species
is: SBO:0000247
is: CHEBI:61430
boundary condition: false
constant: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR RIBt
is described by: ECO:0000000
type: Reaction
name: ribose transport via diffusion
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_ddafed36_f3d7_47d5_af01_55affecce5e3
initial amount: NaN
boundary condition: true
name: PAH
is encoded by: hsa:5053
is: SBO:0000252
has only substance units: false
is: P00439
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_9529dbbc_bcd9_46d6_bcc9_54e5837388ec
name: PTGS2
is: P35354
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5743
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_5cac0a18_a439_4d34_98b1_ba444c73b4f5
is: P27707
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1633
name: DCK

metaM acac m
name: acetoacetate
constant: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:13705

metaM glu L r
constant: false
name: L-glutamate(1-)
has only substance units: false
initial amount: NaN
is: HMDB00148
is: CHEBI:29985
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR RAI1
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: retinal isomerase (11-cis)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reversible: true
type: Reaction

metaM ocdcea e
is: C00712
initial amount: NaN
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: HMDB00207
constant: false
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_8ffd5a6a_2946_4bc2_8c57_f92c53e6e447
type: Species
is: Q16836
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: HADH
initial amount: NaN
is encoded by: hsa:3033

metaM C05280 m
is: HMDB03952
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:28002
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
initial concentration: 1.0
boundary condition: false
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN

metaR r0340
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110044#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.38

metaR r1651
is described by: ECO:0000000
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
reversible: true

metaR DNDPt9m
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
fast: false
name: dADP transport via dTDP antiport
is described by: ECO:0000269

metaR r1429
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Free diffusion
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_29acd0d0_710a_4353_9ea8_a71aea242dc6
constant: false
is encoded by: hsa:W74642
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _W74642_1_c
boundary condition: true
is: SBO:0000252
type: Species

metaM HC02213 c
name: prostaglandin-e3
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false
is: CHEBI:28031
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_073e8d27_b2b4_489e_a1a2_ac7b673ef59d
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: SLC19A3
is: SBO:0000252
is: Q9BZV2
is encoded by: hsa:80704

http://identifiers.org/biomodels.db/MODEL1310110044#_07626029_131c_434c_b4cd_33316344cc56
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9UJA2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:54675
name: CRLS1

metaR DCK2n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction
is described by: ECO:0000269
product: MODEL1310110044#
name: Deoxycytidine kinase, nuclear (UTP)
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.74
kinetic law: MODEL1310110044#
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_72f8f77b_9d75_4512_af53_81c45b9b9c9d
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:549
is: Q13825
has only substance units: false
initial concentration: NaN
boundary condition: true
name: AUH

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_1fc22602_6106_4575_8bb1_59d766d4f4f7
is encoded by: hsa:3939
type: Species
is: SBO:0000252
is: P00338
name: LDHA
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaR RE1530M
is: SBO:0000176
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.21
is described by: ECO:0000000
name: RE1530
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

metaR ACCOAtn
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: acetyl-CoA transport, nuclear
is: SBO:0000185
type: Reaction
reversible: true

metaM val L m
name: L-valine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
is: CHEBI:16414
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00883
has only substance units: false
initial amount: NaN
constant: false

metaR RAI2
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
name: retinal isomerase (9-cis)

metaR RE3005M
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
name: RE3005
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR r1652
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
type: Reaction
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8855fad4_9e5e_47f6_a7df_0c62069bbe23
is: SBO:0000252
has only substance units: false
is encoded by: hsa:767
is: P35219
boundary condition: true
initial amount: NaN
name: CA8
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_08d1503b_ec0e_4a49_8267_a88ac3b9a1c4
constant: false
is encoded by: hsa:7084
boundary condition: true
initial concentration: NaN
type: Species
is: O00142
has only substance units: false
name: TK2
initial amount: NaN
is: SBO:0000252

metaM HC01408 m
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: CHEBI:27648
type: Species
boundary condition: false
name: 3-Oxohexanoyl-CoA
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0

metaM 2kmb c
initial concentration: 1.0
constant: false
notes: FORMULA: C5H7O3S CHARGE: -1
boundary condition: false
type: Species
is: HMDB01553
is: CHEBI:16723
name: 2-keto-4-methylthiobutyrate
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM dmpp x
has only substance units: false
is: CHEBI:57623
name: prenyl diphosphate(3-)
boundary condition: false
type: Species
is: HMDB01120
constant: false
is: SBO:0000247
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_0383041f_6b74_426e_9f6f_7b40054562bd
type: Species
is encoded by: hsa:226
has only substance units: false
constant: false
initial amount: NaN
name: ALDOA
initial concentration: NaN
is: P04075
boundary condition: true
is: SBO:0000252

metaR r2380
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185

metaR HMGCOAtx
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is: SBO:0000185
type: Reaction
reversible: true
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

metaR FAOXC163C164Gm
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM 3hmp m
initial amount: NaN
is: CHEBI:11805
has only substance units: false
type: Species
is: HMDB00023
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoate
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false

metaR r0917
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_98b4f238_4d1c_4f52_8d1d_23859b3a0a49
initial amount: NaN
initial concentration: NaN
is: Q9NY65
name: EHHADH
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1962
is: SBO:0000252
type: Species

metaR r0879
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_15b016f8_63a9_4da4_a016_ec8ad9b2c37d
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2987
type: Species
is: Q16774
initial amount: NaN
name: GUK1
initial concentration: NaN
has only substance units: false

metaM dece3coa m
constant: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
boundary condition: false
name: 3-decenoylcoa
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_7a1a172a_d128_458b_a2f9_7a1685af7d73
has only substance units: false
name: PDE4B
constant: false
is: Q5TEK5
is encoded by: hsa:5142
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM pyr m
is: C00022
is: CHEBI:15361
boundary condition: false
is: HMDB00243
type: Species
constant: false
name: pyruvate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

http://identifiers.org/biomodels.db/MODEL1310110044#_b90e3d7b_df7f_4c3b_b56c_67a0548dff99
boundary condition: true
is encoded by: hsa:6916
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: TBXAS1
is: SBO:0000252
is: Q53F23
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_dea6fd11_eea1_4ea2_bf11_292044d01ce7
has only substance units: false
is encoded by: hsa:84890
initial concentration: NaN
is: SBO:0000252
is: B3KXN9
type: Species
name: ADO
constant: false
boundary condition: true
initial amount: NaN

metaR r1933
reversible: false
modifier: MODEL1310110044#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR BALAPAT1tc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine by PAT1 in renal and intestinal cells
type: Reaction

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR HSD3A1r
type: Reaction
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.225
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_0f57595f_ee07_4e5f_8df5_597ffa14c3a5
boundary condition: true
initial concentration: NaN
name: GGT1
has only substance units: false
type: Species
is encoded by: hsa:2678
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2381
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
product: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaM tchola c
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
is: HMDB00036
is: SBO:0000247
type: Species
name: taurocholic acid

http://identifiers.org/biomodels.db/MODEL1310110044#_c58d5705_2e05_4c21_a947_d6da982cc564
name: PLCB3
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5331
is: SBO:0000252
initial concentration: NaN
is: G5E960

metaM 5mta e
name: 5-Methylthioadenosine
is: CHEBI:17509
is: SBO:0000247
notes: FORMULA: C11H15N5O3S CHARGE: 0
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: C00170
type: Species
has only substance units: false
is: HMDB01173

http://identifiers.org/biomodels.db/MODEL1310110044#_47b8baea_e9a8_46c8_af8d_352269b9a368
is: SBO:0000252
name: MTMR1
boundary condition: true
constant: false
type: Species
is encoded by: hsa:8776
has only substance units: false
initial concentration: NaN
is: Q13613
initial amount: NaN

metaR r1650
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR RAI4
is: SBO:0000176
reversible: true
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
type: Reaction
name: 13-cis-4-oxo-retinoic acid isomerase
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000

metaM arg L c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00517
has only substance units: false
is: CHEBI:32682
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

http://identifiers.org/biomodels.db/MODEL1310110044#_5af4af65_e421_4131_b15e_a618d45e9772
initial amount: NaN
is: O75610
initial concentration: NaN
type: Species
name: LEFTY1
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:10637
has only substance units: false

metaR r1428
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
name: Free diffusion
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_05b719f3_6781_4805_bf9d_1f5f644a690f
is: Q15181
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: PPA1
boundary condition: true
type: Species
is encoded by: hsa:5464
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_ed032a2d_46a4_4dee_831b_9a7fd4d4c784
is: SBO:0000252
is encoded by: hsa:218
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: P30838
constant: false
name: ALDH3A1
initial concentration: NaN

metaM mlthf c
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
has only substance units: false
is: C00143
type: Species
initial amount: NaN
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: CHEBI:15636
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_47a9d103_0e37_46dc_99ae_b8a77c6978c7
is: SBO:0000252
name: NMNAT2
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:23057
initial concentration: NaN
constant: false

metaR r2382
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM HC02203 e
type: Species
constant: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: prostaglandin-a2
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_945cb726_194e_4347_a1ca_cedd214ebfa2
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ALDH3A2
is: P51648
is encoded by: hsa:224
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_d69ebcb5_d081_4992_bae8_cae77bd6801e
initial amount: NaN
has only substance units: false
is encoded by: hsa:3948
is: SBO:0000252
name: LDHC
initial concentration: NaN
is: P07864
boundary condition: true
constant: false
type: Species

metaR PRODt2r
name: D-proline reversible transport via proton symport
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110044#_37a25198_dd28_432c_9f49_773e7e1a2224
type: Species
initial amount: NaN
is: B7Z792
is: SBO:0000252
name: NDUFS2
constant: false
is encoded by: hsa:4720
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_6428d99d_0a86_449a_a371_adabf36001d7
type: Species
name: DHCR24
boundary condition: true
constant: false
is encoded by: hsa:1718
initial concentration: NaN
is: SBO:0000252
is: Q15392
initial amount: NaN
has only substance units: false

metaM dgtp c
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:16497
constant: false
is: SBO:0000247
name: dGTP
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
initial amount: NaN
initial concentration: 1.0

metaM c6crn e
name: hexanoyl carnitine
initial amount: NaN
is: HMDB00705
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C13H25NO4 CHARGE: 0
constant: false

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_73780b91_88e3_4695_af82_7ec65ace1753
is encoded by: hsa:10637
has only substance units: false
boundary condition: true
name: LEFTY1
initial amount: NaN
is: O75610
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_bd4911b6_76ee_4c91_8233_ce845128cc39
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: Q9BWD1
is encoded by: hsa:39
has only substance units: false
is: SBO:0000252
name: ACAT2
initial amount: NaN

metaM pail35p hs c
initial amount: NaN
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_f705df28_be27_445b_ae55_6de5f04bf647
initial concentration: NaN
constant: false
name: NME1
boundary condition: true
is encoded by: hsa:4830
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_02cab643_568b_4d32_bc0f_5fd61a7d96b2
is encoded by: hsa:125061
has only substance units: false
is: SBO:0000252
is: Q63HM1
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: AFMID

metaM tchola e
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00036
name: taurocholic acid
initial amount: NaN
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7783f466_4f9c_4ab5_8aa1_0ec76aeffd7f
is: O60312
initial amount: NaN
is encoded by: hsa:57194
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: ATP10A

metaM HC01602 c
boundary condition: false
type: Species
initial amount: NaN
is: C00234
constant: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
is: CHEBI:57454
has only substance units: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0983
product: MODEL1310110044#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000

metaR r2443
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
kinetic law: MODEL1310110044#
fast: false

metaM 5mta c
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
name: 5-Methylthioadenosine
type: Species
is: SBO:0000247
is: HMDB01173
initial concentration: 1.0
is: CHEBI:17509
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: C00170

metaM 5mdru1p c
is: C04582
constant: false
initial amount: NaN
notes: FORMULA: C6H11O7PS CHARGE: -2
initial concentration: 1.0
type: Species
boundary condition: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
is: HMDB01299
is: CHEBI:58548
has only substance units: false
is: SBO:0000247

metaM dudp n
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
is: HMDB01000
initial concentration: 1.0
is: CHEBI:60471
type: Species
boundary condition: false
name: dUDP(3-)

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM 4mzym int1 r
has only substance units: false
name: 4-Methylzymosterol intermediate 1
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial amount: NaN
is: HMDB06927
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r0779
reactant: MODEL1310110044#
type: Reaction
reversible: false
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110044#_ccb88f03_609e_4956_8641_a826cedc03eb
name: ST20
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:400410
is: Q9HBF5
type: Species
is: SBO:0000252

metaR HEX7
name: hexokinase (D-fructose:ATP)
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110044#
is: SBO:0000176

metaR r0345
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11

metaM dhap c
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: HMDB01473
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57642
is: C00111
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
type: Species

metaR TMDK1
reactant: MODEL1310110044#
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
name: thymidine kinase (ATP:thymidine)
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110044#

metaM xylu L c
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
type: Species
boundary condition: false
name: L-xylulose
is: SBO:0000247
is: CHEBI:17399
constant: false
initial amount: NaN
is: HMDB00751
initial concentration: 1.0

metaM c226coa c
is: http://identifiers.org/pubchem.compound/47205479
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
name: cervonyl coenzyme A
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: C16169

metaR LTC4Sr
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
is version of: http://identifiers.org/ec-code/4.4.1.20
reversible: false
product: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
type: Reaction
name: Leukotriene C4 synthase
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_cff3d439_3a3d_4c9a_8ed9_6f6fdf341ed0
type: Species
has only substance units: false
boundary condition: true
is: Q86YW0
is encoded by: hsa:89869
name: PLCZ1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ocdcea c
initial concentration: 1.0
is: HMDB00207
is: C00712
constant: false
initial amount: NaN
has only substance units: false
name: octadecenoate (n-C18:1)
type: Species
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
is: SBO:0000247

metaM dhap e
is: SBO:0000247
is: HMDB01473
constant: false
is: CHEBI:57642
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
name: glycerone phosphate(2-)
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_f10583d7_28fb_4e7d_96e2_1c61fedd6ba5
is: B3KUK6
boundary condition: true
name: NT5C1B
constant: false
type: Species
is encoded by: hsa:93034
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r2384
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
product: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110044#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7d0c5d9e_4024_420f_9d5d_963ab7524d5c
has only substance units: false
boundary condition: true
is encoded by: hsa:501
initial concentration: NaN
constant: false
is: E7EPT3
name: ALDH7A1
is: SBO:0000252
type: Species
initial amount: NaN

metaR LYStiDF
modifier: MODEL1310110044#
name: L-lysine transport via diffusion (extracellular to cytosol)
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110044#
fast: false

metaM 3sala c
initial amount: NaN
constant: false
name: 3-Sulfino-L-alanine
is: SBO:0000247
is: CHEBI:61085
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
has only substance units: false
type: Species
is: C00606

metaR BILIRUBt2
is: SBO:0000185
is described by: ECO:0000269
fast: false
modifier: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reactant: MODEL1310110044#

metaM h2o x
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: HMDB02111
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00001
is: SBO:0000247
is: CHEBI:15377
name: H2O
constant: false

metaM cmpacna c
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
initial amount: NaN
constant: false
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_75b849fd_88d6_45ba_b059_9812d5b1e6d9
name: GCK
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: P35557
initial amount: NaN
is encoded by: hsa:2645
type: Species
has only substance units: false

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM dgtp e
constant: false
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
name: dGTP
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01440
initial concentration: 1.0

metaM dutp m
is: CHEBI:17625
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
is: HMDB01191

metaM HC02213 e
initial amount: NaN
name: prostaglandin-e3
constant: false
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
boundary condition: false
is: CHEBI:28031
type: Species
is: SBO:0000247

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM pa hs c
initial amount: NaN
is: CHEBI:57739
constant: false
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
boundary condition: false
name: phosphatidate(2-)
initial concentration: 1.0
is: SBO:0000247

metaM 7dhf e
is: HMDB06559
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: heptaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110044#_a08e7b24_b82b_48ec_b0e8_f4caf3633f07
initial amount: NaN
has only substance units: false
is encoded by: hsa:84701
boundary condition: true
name: COX4I2
is: Q96KJ9
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_ed7e549f_251c_4d1c_99cb_5b1f6a95c993
initial concentration: NaN
is: Q08499
initial amount: NaN
name: PDE4D
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5144
constant: false

metaM c6crn c
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C13H25NO4 CHARGE: 0
initial amount: NaN
is: HMDB00705
constant: false
initial concentration: 1.0
has only substance units: false
name: hexanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110044#_c70c7e97_4265_4a29_89ba_abd6ca640032
initial concentration: NaN
is encoded by: hsa:NM 013421
name: _NM_013421_1_m
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r2385
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000

metaR EX ptth LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ptth
type: Reaction

metaR ITCOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110044#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_7f5576ed_b8c4_4226_98dc_c90eee85402e
boundary condition: true
initial amount: NaN
is encoded by: hsa:BF195998
is: SBO:0000252
name: _BF195998_1_x
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM dpcoa m
is: HMDB01373
type: Species
boundary condition: false
name: 3'-dephospho-CoA(2-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
has only substance units: false
is: SBO:0000247

metaM 3hpcoa m
type: Species
is: CHEBI:58528
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
has only substance units: false
name: 3-hydroxypropanoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
is: HMDB06807
constant: false

metaR MI13PP
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110044#
name: inositol-1,3-bisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#

metaM lnlccoa c
name: linoleic coenzyme A
has only substance units: false
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR RE1525M
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
name: RE1525
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
fast: false

metaM dtmp c
name: dTMP
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01227
is: CHEBI:26999
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364

metaR r0410
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110044#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM leuktrA4 c
initial concentration: 1.0
name: leukotriene A4(1-)
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
boundary condition: false
is: HMDB01337
is: SBO:0000247
is: CHEBI:57463
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2cc3c356_e0b4_442d_a715_01ec72fdced2
is encoded by: hsa:57665
boundary condition: true
name: RDH14
is: Q9HBH5
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_28ec6ae5_40b7_4154_a989_cd511dca6eab
is encoded by: hsa:4842
name: NOS1
boundary condition: true
has only substance units: false
is: B4DG68
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_c659fb3d_da52_4bb0_913b_4f331245b75f
is: Q9NS18
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:51022
initial concentration: NaN
name: GLRX2

http://identifiers.org/biomodels.db/MODEL1310110044#_3ed0f18d_b3a1_4444_9140_23373c267c12
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q14916
name: SLC17A1
type: Species
is encoded by: hsa:6568
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_7b5e47bb_9588_41b5_a1a4_8392c106b158
initial concentration: NaN
is: P60891
name: PRPS1
is encoded by: hsa:5631
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR r1658
kinetic law: MODEL1310110044#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_10783682_f284_4e11_a529_6a93d98a182e
is: SBO:0000252
type: Species
is encoded by: hsa:3032
has only substance units: false
boundary condition: true
constant: false
name: HADHB
initial concentration: NaN
initial amount: NaN
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110044#_f5d26593_9151_45e8_b1dc_7ae3833ebe01
has only substance units: false
is: SBO:0000252
name: _AA419122_1_c
is encoded by: hsa:AA419122
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_50206950_fbfd_4630_9130_1a368fcad546
is: SBO:0000252
name: EGFL8
initial concentration: NaN
type: Species
is encoded by: hsa:80864
constant: false
is: Q99944
initial amount: NaN
has only substance units: false
boundary condition: true

metaR DOCO13EFATP
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR GLYt2r
modifier: MODEL1310110044#
product: MODEL1310110044#
name: glycine reversible transport via proton symport
type: Reaction
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000304

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR DESAT22 2p
reversible: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
type: Reaction

metaR LEUKTRA4tr
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
is: SBO:0000185
name: leukotriene intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
product: MODEL1310110044#
is described by: ECO:0000000

metaM triodthy e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
is: HMDB00265
type: Species
constant: false
is: CHEBI:18258

metaM o2s e
initial concentration: 1.0
is: CHEBI:18421
is: SBO:0000247
constant: false
is: HMDB02168
boundary condition: false
name: superoxide
type: Species
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN

metaM dcdp n
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
name: dCDP(3-)
type: Species
is: CHEBI:58593
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR PCHOL HStg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
name: phosphatidylcholine scramblase
product: MODEL1310110044#
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110044#

metaM cdp c
is: HMDB01546
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: C00112
initial amount: NaN
boundary condition: false
name: CDP
has only substance units: false
is: SBO:0000247

metaR r1657
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
fast: false

metaM 10fthf5glu e
type: Species
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial amount: NaN
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](5)
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR RE3346M
reactant: MODEL1310110044#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
name: RE3346
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
name: 2-Amino-3-oxoadipate
has only substance units: false
is: SBO:0000247
is: CHEBI:28095
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaR SPHS1Ptr
reversible: true
type: Reaction
fast: false
product: MODEL1310110044#
name: sphingosine-1-phosphate transport
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#

metaR LEUTAm
name: leucine transaminase, mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
kinetic law: MODEL1310110044#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR r0494
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000

metaR DCTPtn
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
product: MODEL1310110044#
name: dCTP diffusion in nucleus
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_be439045_293c_4f80_b540_07cc54aba318
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: _AI926493_1_m
is encoded by: hsa:AI926493

metaR PROIMINOtc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Proline by the apical IMINO amino acid transporters in kidney and intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_2318acf0_7ef7_40e2_a37c_9cce0003acc6
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: MTHFS
is encoded by: hsa:10588
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P49914

metaR r1446
product: MODEL1310110044#
name: EC:1.3.3.6
is: SBO:0000176
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
fast: false

metaR FACOAL140i
is: SBO:0000176
reversible: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
product: MODEL1310110044#
is described by: ECO:0000269
name: fatty-acid--CoA ligase (tetradecanoate)
kinetic law: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_315a29cf_bb63_4b6f_9fba_948f3bcda9a0
has only substance units: false
type: Species
constant: false
is: P32321
is: SBO:0000252
name: DCTD
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1635

http://identifiers.org/biomodels.db/MODEL1310110044#_cd89f94c_fb9c_43a7_9a98_3998c8afc889
initial concentration: NaN
name: ACADVL
is: SBO:0000252
is: P49748
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:37

metaR DMATTx
fast: false
is described by: ECO:0000134
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.5.1.1
name: dimethylallyltranstransferase
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#

metaM dcdp m
initial concentration: 1.0
name: dCDP(3-)
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58593
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_4fe0c4ae_2fe0_4a2e_8513_ccd1d6ae722d
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: _AI972237_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI972237

http://identifiers.org/biomodels.db/MODEL1310110044#_8565ffb5_320b_4da2_9d4f_cc85adf2bad0
is: SBO:0000252
is encoded by: hsa:5464
type: Species
initial amount: NaN
has only substance units: false
is: Q15181
constant: false
initial concentration: NaN
boundary condition: true
name: PPA1

metaR FAOXC123C102m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_2ed5f989_2d93_460c_b26e_1d4fe8809dab
has only substance units: false
is encoded by: hsa:8611
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: G3XA95
name: PPAP2A
is: SBO:0000252

metaR r1591
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
product: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_6f246fd2_1727_4481_b2ee_5304c031e943
name: GGT1
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2678
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

metaM btn e
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00030
is: C00120
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
name: Biotin
initial concentration: 1.0

metaM CE5132 c
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_ec2098a2_63e5_4bf4_86cd_f566d6014d60
is: SBO:0000252
initial concentration: NaN
type: Species
is: P31350
name: RRM2
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6241

metaM mlthf m
has only substance units: false
initial amount: NaN
is: C00143
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:15636

metaR PROSTGE2t2
name: prostaglandin uniport
is: SBO:0000185
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b771467a_d436_4ccd_b348_52be3aafa513
constant: false
type: Species
initial amount: NaN
name: INPP5J
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:27124
is: SBO:0000252

metaR r1659
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110044#
is: SBO:0000185

metaM cdp e
constant: false
type: Species
name: CDP(3-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01546

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaR r1590
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE1926 e
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: gama-carboxyethyl-hydroxychroman
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748

metaM 2octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: 2,6,9,12,15-octadecapentenoylcoa
type: Species
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110044#_dfc156a7_32d8_4da6_aa8b_5616dded7ced
is: Q9UGQ3
is encoded by: hsa:11182
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC2A6
is: SBO:0000252

metaR FADtx
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: FAD transporter, peroxisomal
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reversible: true

metaM cl e
is: SBO:0000247
name: Chloride
initial amount: NaN
is: C00115
has only substance units: false
type: Species
is: HMDB00492
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
is: CHEBI:3966
constant: false
initial concentration: 1.0

metaM dtmp e
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
initial amount: NaN
type: Species
is: HMDB01227
name: dTMP(2-)
constant: false
is: SBO:0000247

metaM omhpal c
initial concentration: 1.0
has only substance units: false
name: w-hydroxypalmiticacid
constant: false
initial amount: NaN
is: HMDB06294
notes: FORMULA: C16H30O3 CHARGE: -1
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_a358d384_adbf_46f6_9414_4f4e0b30e8f4
constant: false
is encoded by: hsa:6566
boundary condition: true
initial amount: NaN
name: SLC16A1
type: Species
is: B4DKS0
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r1654
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000

metaM co2 m
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
has only substance units: false
is: CHEBI:16526
constant: false
is: HMDB01967
is: SBO:0000247
type: Species
boundary condition: false
name: CO2
is: C00011

metaR FAOXC101C102m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c984ac7b_067d_453f_83e0_ad0acec228eb
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: P17174
name: GOT1
initial concentration: NaN
is encoded by: hsa:2805

http://identifiers.org/biomodels.db/MODEL1310110044#_6cc6f19a_51a1_4bf9_a5ed_929fba8f1db9
is: P48426
name: PIP4K2A
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5305
constant: false
initial concentration: NaN
is: SBO:0000252

metaM akg e
is: SBO:0000247
is: HMDB00208
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
is: CHEBI:16810
initial amount: NaN
name: 2-oxoglutarate(2-)

http://identifiers.org/biomodels.db/MODEL1310110044#_0459949e_5695_49d2_979d_fc95be46a441
boundary condition: true
is: Q99489
constant: false
name: DDO
is encoded by: hsa:8528
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM glu5sa m
initial concentration: 1.0
is: HMDB02104
is: CHEBI:17232
initial amount: NaN
type: Species
is: C01165
has only substance units: false
name: L-Glutamate 5-semialdehyde
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
boundary condition: false
constant: false
is: SBO:0000247

metaR NDPK3n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is described by: ECO:0000304

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM dutp c
name: dUTP
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: C00460
constant: false
is: HMDB01191
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17625

metaR GGT5r
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
is: SBO:0000176
reversible: true
fast: false
name: Gamma-glutamyltransferase 5
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction

metaM ile L c
is: SBO:0000247
is: CHEBI:17191
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
is: HMDB00172
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaM dgtp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
is: CHEBI:16497
constant: false
name: dGTP
is: C00286
boundary condition: false
initial concentration: 1.0
is: HMDB01440
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r2331
kinetic law: MODEL1310110044#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r1593
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaM hista c
is: HMDB00870
name: histamium
is: CHEBI:58432
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

http://identifiers.org/biomodels.db/MODEL1310110044#_8e21819d_6aa7_440f_adb6_77ece0cebb69
initial amount: NaN
name: AMY2B
constant: false
is: SBO:0000252
is: P19961
has only substance units: false
initial concentration: NaN
is encoded by: hsa:280
boundary condition: true
type: Species

metaM cmp n
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
initial amount: NaN
name: CMP(2-)
has only substance units: false
is: CHEBI:60377
boundary condition: false

metaM 3ohdcoa x
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: HMDB06402
initial amount: NaN
initial concentration: 1.0
constant: false
name: 3-oxopalmitoyl-CoA(4-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57349
has only substance units: false
type: Species

metaR r1653
product: MODEL1310110044#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c9dc458e_b2e8_4a94_8cf3_144909a2b5b6
initial amount: NaN
is: SBO:0000252
is: F5GWR4
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:9481
type: Species
name: SLC25A27

metaR DUDPtn
name: dUDP nuclear transport
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110044#
is: SBO:0000185

metaM pan4p c
initial amount: NaN
is: CHEBI:47942
constant: false
is: HMDB01416
is: C01134
boundary condition: false
is: SBO:0000247
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
initial concentration: 1.0
has only substance units: false

metaM pro D e
constant: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
is: CHEBI:16313
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB03411
boundary condition: false
name: D-proline

http://identifiers.org/biomodels.db/MODEL1310110044#_1154caf8_07aa_4014_aec6_e6416a6c93f6
constant: false
is: P00915
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:759
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CA1

http://identifiers.org/biomodels.db/MODEL1310110044#_924751c1_653e_453e_a9b7_63463f4e504f
initial concentration: NaN
name: PTEN
constant: false
has only substance units: false
is: F6KD01
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:5728

metaR r2330
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_14b4d891_6bd8_4c90_9c2c_135cb5195aea
name: SDHA
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: P31040
initial amount: NaN
has only substance units: false
is encoded by: hsa:6389
initial concentration: NaN

metaM 4hoxpacd c
is: CHEBI:15621
is: SBO:0000247
name: (4-hydroxyphenyl)acetaldehyde
boundary condition: false
initial amount: NaN
is: HMDB03767
has only substance units: false
constant: false
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
initial concentration: 1.0
type: Species

metaM itp c
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
is: SBO:0000247
is: HMDB00189
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57614
initial concentration: 1.0
has only substance units: false
name: ITP(3-)

http://identifiers.org/biomodels.db/MODEL1310110044#_b59d9b6f_baf5_4a92_841e_f5a286dd0a29
type: Species
boundary condition: true
is encoded by: hsa:2747
initial concentration: NaN
is: P49448
is: SBO:0000252
constant: false
name: GLUD2
initial amount: NaN
has only substance units: false

metaM cl c
is: CHEBI:3966
constant: false
initial amount: NaN
is: C00115
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
type: Species
is: HMDB00492
is: SBO:0000247
name: Chloride

metaM dgtp m
type: Species
constant: false
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
name: dGTP
is: CHEBI:16497
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR RE3627M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3627
product: MODEL1310110044#
type: Reaction

metaR HMGLx
reversible: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
fast: false
name: hydroxymethylglutaryl-CoA lyase
product: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.3.4
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#

metaM HC02208 e
boundary condition: false
is: CHEBI:27696
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
is: SBO:0000247
constant: false
name: prostaglandin-d1
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_d65d1eb3_99f6_496a_af0b_4d717c3b490b
name: _BE966236_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:BE966236
constant: false

metaM akg c
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00208
initial concentration: 1.0
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
is: SBO:0000247
name: 2-Oxoglutarate
is: CHEBI:16810

metaR r0139
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.2.2
product: MODEL1310110044#

metaR r1656
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_fe13d097_667f_4267_9613_df495c975895
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110044#_7883cae4_44fd_4f34_8737_03a20d4704bc
boundary condition: true
is: P19440
name: GGT1
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2678
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_e5fbbbf4_fe9e_494d_8983_0bfbc7f36c15
constant: false
name: _AI348006_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI348006
type: Species
initial amount: NaN

metaM e4hglu m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:6331
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
type: Species
initial concentration: 1.0
name: erythro-4-hydroxy-L-glutamate(1-)
is: HMDB02273

metaR DHCR71r
is: SBO:0000176
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.1.21
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
name: 7-dehydrocholesterol reductase
fast: false
product: MODEL1310110044#
type: Reaction

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
fast: false

metaR Htx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
name: H transporter, peroxisome
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
is described by: ECO:0000000

metaM ile L e
initial amount: NaN
boundary condition: false
is: HMDB00172
name: L-isoleucine
constant: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: CHEBI:17191
initial concentration: 1.0
has only substance units: false

metaM hexdiac r
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
initial concentration: 1.0
constant: false
boundary condition: false
is: C08260
name: hexadecanediocacid

http://identifiers.org/biomodels.db/MODEL1310110044#_acc670c7_858d_4059_91ed_fbb2a0c6c49a
initial amount: NaN
has only substance units: false
name: SCP2
is: C9JC79
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6342

http://identifiers.org/biomodels.db/MODEL1310110044#_c2c19e44_c1af_4a1e_a8c0_2ce89827fffd
constant: false
boundary condition: true
is encoded by: hsa:10797
initial amount: NaN
name: MTHFD2
initial concentration: NaN
is: P13995
is: SBO:0000252
type: Species
has only substance units: false

metaR RETNtr
is: SBO:0000185
product: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:14704335 NOTES:IT
name: retinoic acid transport in ER
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
fast: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM maltttr e
boundary condition: false
is: C02052
initial concentration: 1.0
is: SBO:0000247
is: HMDB01296
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
type: Species
name: Maltotetraose
constant: false
has only substance units: false

metaR r1595
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_1c097117_ae29_4476_bd17_9fc13ef4ec2d
is encoded by: hsa:4701
is: SBO:0000252
constant: false
has only substance units: false
name: NDUFA7
initial amount: NaN
type: Species
is: Q6FG42
boundary condition: true
initial concentration: NaN

metaM nad x
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
name: Nicotinamide adenine dinucleotide
constant: false
is: HMDB00902
initial concentration: 1.0
is: CHEBI:57540
is: SBO:0000247
type: Species
is: C00003
boundary condition: false
initial amount: NaN

metaR r1655
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaM hista e
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
is: CHEBI:58432
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB00870
initial concentration: 1.0

metaM triodthy c
constant: false
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00265
initial concentration: 1.0
is: CHEBI:18258

http://identifiers.org/biomodels.db/MODEL1310110044#_82270b8a_b558_4b82_adb0_eae3ae42e408
type: Species
is: Q9BXS1
name: IDI2
is encoded by: hsa:91734
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaM asp D c
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: D-aspartate(1-)
constant: false
is: CHEBI:29990
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
is: HMDB06483
has only substance units: false
initial concentration: 1.0

metaM pan4p e
initial concentration: 1.0
is: CHEBI:47942
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
type: Species
constant: false
is: C01134
name: Pantetheine 4'-phosphate
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR GHMT2rm
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
kinetic law: MODEL1310110044#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reversible: true
is: SBO:0000176
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.1.2.1
is described by: ECO:0000269
type: Reaction

metaM o2s c
has only substance units: false
initial amount: NaN
is: HMDB02168
is: CHEBI:18421
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide

http://identifiers.org/biomodels.db/MODEL1310110044#_63419ac0_7072_46e6_88bf_441700ccac5a
initial amount: NaN
is: SBO:0000252
constant: false
is: P53597
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SUCLG1
is encoded by: hsa:8802

metaR RE2269E
reversible: true
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110044#
reactant: MODEL1310110044#

metaM h2o r
initial amount: NaN
constant: false
is: HMDB02111
is: C00001
is: CHEBI:15377
is: SBO:0000247
name: H2O
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_8cd37199_ff60_4b76_830b_59297787f759
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r2332
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_07c5c92c_0569_40b8_8f7f_f9c99112e3cd
name: SLC6A3
is encoded by: hsa:6531
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q01959
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_ab5576df_0e0d_4a73_9c99_9f60107b906e
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: CA5A
is: P35218
has only substance units: false
initial concentration: NaN
is encoded by: hsa:763

metaM i e
type: Species
is: CHEBI:16382
is: HMDB12238
name: iodide
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM HC02208 c
name: prostaglandin-d1
is: CHEBI:27696
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM 7thf e
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial amount: NaN
is: HMDB06559
has only substance units: false
name: heptaglutamyl folate (THF)
initial concentration: 1.0
constant: false

metaR NDPK10n
product: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
type: Reaction
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reversible: true
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is described by: ECO:0000304

metaR r1594
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR r1597
product: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
type: Reaction
fast: false

metaR r0287
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: false
product: MODEL1310110044#
fast: false
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_bc3f2cb1_8fea_45bf_a2f0_502310454d7c
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: DGKB
is: Q9Y6T7
type: Species
has only substance units: false
is encoded by: hsa:1607

metaR r1384
fast: false
is described by: ECO:0000000
reversible: true
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR RE2659R
product: MODEL1310110044#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110044#
fast: false
name: RE2659
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction

metaM 3m4hpga c
initial amount: NaN
is: HMDB04061
has only substance units: false
is: http://identifiers.org/pubchem.compound/7909
is: SBO:0000247
constant: false
is: C05583
type: Species
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
boundary condition: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
initial concentration: 1.0

metaM taur e
has only substance units: false
initial amount: NaN
is: HMDB00251
name: Taurine
is: C00245
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
is: CHEBI:3544
type: Species
is: SBO:0000247

metaM dgchol c
is: HMDB00637
initial amount: NaN
boundary condition: false
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaR ACACT1rm
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110044#

metaR r2335
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110044#
is: SBO:0000185
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM hexde7coa x
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02288
type: Species
initial concentration: 1.0
constant: false
name: 7-hexadecenoylcoa
initial amount: NaN

metaR r1596
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_3591a328_e272_494d_a598_698b9b96f6ee
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: _286297_1_c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:286297

http://identifiers.org/biomodels.db/MODEL1310110044#_a3777e72_cc14_42b3_b471_80bf14855b5b
boundary condition: true
initial concentration: NaN
type: Species
name: SOD2
is: P04179
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6648
initial amount: NaN

metaR r2334
reactant: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM gal c
is: HMDB00143
is: C00124
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
is: SBO:0000247
is: CHEBI:0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: D-Galactose
initial concentration: 1.0

metaR C6CRNtcx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR NDPK9n
kinetic law: MODEL1310110044#
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is: SBO:0000176

metaM fpram c
is: C04640
initial amount: NaN
constant: false
type: Species
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: CHEBI:58478
is: HMDB06211
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640

http://identifiers.org/biomodels.db/MODEL1310110044#_8c107f9d_23e4_45de_81fe_7b69a53039ac
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:219
initial concentration: NaN
is: P30837
has only substance units: false
constant: false
name: ALDH1B1
is: SBO:0000252

metaM asp D e
is: CHEBI:29990
is: HMDB06483
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
constant: false
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: D-aspartate(1-)

http://identifiers.org/biomodels.db/MODEL1310110044#_b83c184c_b420_4180_b51b_c32fd7826a92
constant: false
name: GGT5
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P36269
is encoded by: hsa:2687
type: Species
initial amount: NaN
initial concentration: NaN

metaM co2 r
is: SBO:0000247
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
is: C00011
is: HMDB01967
is: CHEBI:16526
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaR NDP8
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110044#

metaM 3odcoa m
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:28528
initial amount: NaN
is: HMDB03939
type: Species
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_b09cef84_a4a9_45d7_a7fd_0b6219012fc3
constant: false
name: PIK3CB
is encoded by: hsa:5291
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: B4DER4
has only substance units: false
is: SBO:0000252

metaR FAOXC204C184m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_cf00408e_b385_49c0_9025_458b44d7ffdf
is encoded by: hsa:5740
name: PTGIS
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q16647
type: Species
initial amount: NaN

metaM 10fthf m
type: Species
is: HMDB00972
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM cdp n
is: CHEBI:58069
name: CDP(3-)
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546

metaM taur c
constant: false
is: HMDB00251
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Taurine
boundary condition: false
is: SBO:0000247
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245

http://identifiers.org/biomodels.db/MODEL1310110044#_b8dadf83_1416_456c_b396_3d3a2da24968
is: Q16698
name: DECR1
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:1666
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_ac32b85f_12c4_4983_9d76_c90ed4e34a4b
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:279
boundary condition: true
type: Species
is: SBO:0000252
name: AMY2A
constant: false
has only substance units: false
is: P04746

metaR r0791
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110044#

metaM h2o m
type: Species
boundary condition: false
is: HMDB02111
is: C00001
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: CHEBI:15377

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM 3ohdcoa m
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
has only substance units: false
is: CHEBI:57349
constant: false
boundary condition: false
is: HMDB06402
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 3-oxopalmitoyl-CoA(4-)

metaR RE0453N
fast: false
is: SBO:0000176
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
reversible: true
name: RE0453
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000

metaR r1599
reactant: MODEL1310110044#
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR FAEL205
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: fatty-acyl-CoA elongation (n-C20:5CoA)
fast: false
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110044#

metaR FAEL204
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
name: fatty-acyl-CoA elongation (n-C20:4CoA)

metaM dtmp m
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
initial amount: NaN
type: Species
name: dTMP
constant: false
boundary condition: false
is: CHEBI:26999
is: HMDB01227
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_2eafe25e_9681_4571_b2d2_3b2fafb1e939
type: Species
is encoded by: hsa:276
is: Q6NSB3
initial concentration: NaN
boundary condition: true
name: AMY1A
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM gal e
constant: false
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
initial amount: NaN
is: CHEBI:0
boundary condition: false
type: Species
name: D-Galactose
is: HMDB00143
has only substance units: false
initial concentration: 1.0
is: C00124

metaM dcdp c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
constant: false
is: HMDB01245
has only substance units: false
name: dCDP
is: CHEBI:58593
initial concentration: 1.0
type: Species
is: C00705
boundary condition: false

metaR ASPDxt
name: D-aspartate transport, peroxisomal
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
product: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_6e98909d_e1d7_487a_8d72_3d1f32fd416d
boundary condition: true
is encoded by: hsa:1040
name: CDS1
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: Q92903
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_dfc173de_de51_4a76_b859_89a14fc9919d
type: Species
is encoded by: hsa:AI824319
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AI824319_1_r
is: SBO:0000252
initial amount: NaN
constant: false

metaM chol c
name: Choline
is: HMDB00097
initial amount: NaN
is: C00114
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
boundary condition: false
is: CHEBI:15354
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_6aa1a773_29ef_42b8_acf6_75d0d14c6a0f
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AA629629_1_m
is encoded by: hsa:AA629629
constant: false
initial amount: NaN
type: Species

metaR ICDHyrm
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reactant: MODEL1310110044#
name: Isocitrate dehydrogenase (NADP+)
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
fast: false
reversible: true

metaR RE0915E
type: Reaction
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110044#
name: RE0915
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_2214e20e_f471_4958_8713_30ca7a7d707e
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P47895
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: ALDH1A3
is encoded by: hsa:220

metaM h2o n
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
is: CHEBI:15377
constant: false
initial amount: NaN
is: HMDB02111
name: water

metaR RE0453M
is: SBO:0000176
name: RE0453
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
fast: false

metaR PROSTGD2t
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110044#
reversible: true

metaR FADH2tx
fast: false
product: MODEL1310110044#
reversible: true
name: FADH2 transporter, peroxisomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000

metaM dudp c
has only substance units: false
is: CHEBI:60471
type: Species
is: C01346
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dUDP
is: HMDB01000
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9af932a7_f3fa_4fd2_be95_cf16b81a7e39
is encoded by: hsa:1806
type: Species
boundary condition: true
constant: false
is: Q12882
has only substance units: false
is: SBO:0000252
name: DPYD
initial amount: NaN
initial concentration: NaN

metaR r1598
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110044#

metaR r2537
is: SBO:0000185
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_dddf6b6f_2687_480f_8c60_71f6c7e8f974
initial concentration: NaN
is encoded by: hsa:286016
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: TPI1P2
constant: false
boundary condition: true

metaR SUCCtp
reversible: true
fast: false
name: succinate transporter, peroxisome
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8da8aac0_1737_4e56_b096_9b1e3b995c21
name: PDE11A
boundary condition: true
has only substance units: false
is encoded by: hsa:50940
type: Species
is: Q9HCR9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR RE3568C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
product: MODEL1310110044#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
name: RE3568
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
modifier: MODEL1310110044#
fast: false

metaM btn c
has only substance units: false
initial amount: NaN
name: Biotin
is: CHEBI:3420
type: Species
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: HMDB00030
is: C00120
is: SBO:0000247

metaR FACOAL184
fast: false
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_9c324262_bfb8_4ef1_8b93_a292608ada5b
constant: false
has only substance units: false
is: SBO:0000252
name: ADCY8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:114
boundary condition: true
type: Species
is: Q4F7X0

metaM orot c
initial concentration: 1.0
is: CHEBI:30839
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
name: Orotate
is: HMDB00226
type: Species
boundary condition: false
is: SBO:0000247
is: C00295
initial amount: NaN
has only substance units: false

metaM hdca c
is: HMDB00220
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
is: CHEBI:7896
has only substance units: false
name: palmitate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_dd788007_e089_4d1f_9d99_5f8420f27016
is: SBO:0000252
is encoded by: hsa:79966
is: Q86SK9
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: SCD5
initial concentration: NaN

metaM h2o g
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial amount: NaN
name: water
is: HMDB02111
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaR MMCDm
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.1.1.9
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
name: Methylmalonyl-CoA decarboxylase, mitochondrial
modifier: MODEL1310110044#
fast: false
type: Reaction

metaR STRDNCt
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaM imp c
is: HMDB00175
is: CHEBI:58053
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: IMP
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110044#_5045336e_224a_4d8b_858b_c0b0b7d8a6fa
is encoded by: hsa:AI697028
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: _AI697028_1_m
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR TRPHYDRO2
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is version of: http://identifiers.org/ec-code/1.14.16.4
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110044#
fast: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
modifier: MODEL1310110044#
reversible: false

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a32f4ec5_b914_41e1_aa81_d66bec81aa85
type: Species
is encoded by: hsa:4831
has part: P22392
has part: P15531
is encoded by: hsa:4830
name: NME1:NME2
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000297
boundary condition: true

metaM hxcoa x
boundary condition: false
has only substance units: false
is: HMDB00705
type: Species
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
name: Hexanoyl-CoA (n-C6:0CoA)
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_2ac749c9_5db0_43e2_8ccd_e5d6a8234b66
name: _R33828_1_c
boundary condition: true
is encoded by: hsa:R33828
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR THRGLNexR
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange

metaM acnam c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: N-acetylneuraminate
is: CHEBI:35418
is: HMDB00230
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d2ad0e2f_c398_430c_a164_2a9ff4f0a232
name: ACP5
type: Species
constant: false
is encoded by: hsa:54
initial amount: NaN
is: P13686
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM acetone e
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0
is: CHEBI:15347
initial amount: NaN
has only substance units: false
name: acetone
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01659

metaR r2338
product: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is: SBO:0000185

metaM HC02180 c
name: thromboxane-b2
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial amount: NaN

metaM chol e
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
boundary condition: false
is: CHEBI:15354
constant: false
name: Choline
is: SBO:0000247
is: HMDB00097

metaM lnlccoa r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
constant: false
type: Species
name: linoleic coenzyme A
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_f49d6718_8d8c_459c_a34a_2ef7a3d487bd
boundary condition: true
is: P46721
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:6579
is: SBO:0000252
initial concentration: NaN
name: SLCO1A2
constant: false

metaR MAN6PI
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/5.3.1.8
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000304
product: MODEL1310110044#
fast: false

metaR FAOXC8C6x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaM orot e
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
type: Species
name: orotate
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:30839

metaR DCSPTN1CPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000269
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110044#
name: carnitine O-palmitoyltransferase

metaM 4abutn m
type: Species
boundary condition: false
name: 4-ammoniobutanal
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58264
is: HMDB01080
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b7ee24fd_d91f_4136_b938_0d734bac49bd
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:205
name: AK4
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_759fddd1_450a_49a1_ad64_258d4901f730
constant: false
is: Q8TDB8
is encoded by: hsa:144195
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: SLC2A14
boundary condition: true
type: Species

metaM prostgh2 r
name: prostaglandin H2(1-)
initial amount: NaN
type: Species
is: CHEBI:57405
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaM hdca e
has only substance units: false
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
is: CHEBI:0
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB00220

metaM leuktrA4 e
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
is: HMDB01337
name: leukotriene A4(1-)

metaM acetone c
has only substance units: false
is: HMDB01659
type: Species
boundary condition: false
is: CHEBI:15347
initial amount: NaN
name: acetone
is: SBO:0000247
constant: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_99eb624c_db55_498b_b973_0d2f8a1abb45
constant: false
initial concentration: NaN
is: SBO:0000252
name: CPT1B
type: Species
is encoded by: hsa:1375
is: E9PCP2
initial amount: NaN
boundary condition: true
has only substance units: false

metaM akg m
initial concentration: 1.0
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
has only substance units: false
name: 2-Oxoglutarate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16810

metaR r0130
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaR DCSPTN1CPT2
type: Reaction
is: SBO:0000176
name: carnitine transferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#

metaR OCDCAtr
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM HC02180 e
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: thromboxane-b2
type: Species
initial amount: NaN
constant: false
is: CHEBI:28728
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ddfa6741_c21b_4c82_b141_c8c390241a76
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _H17063_1_c
type: Species
is encoded by: hsa:H17063

metaM CE0785 m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247
name: cis,cis-myristo-5,8-dienoyl-CoA
type: Species
has only substance units: false
is: CHEBI:57795
constant: false

metaR FAOXC163Gm
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM chol g
initial amount: NaN
initial concentration: 1.0
type: Species
name: choline
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
is: HMDB00097

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c2b7163e_6b30_4d78_afc5_26b3ca2398ab
type: Species
initial concentration: NaN
initial amount: NaN
is: O75912
is encoded by: hsa:9162
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: DGKI

http://identifiers.org/biomodels.db/MODEL1310110044#_b99f3cd3_6229_4f57_bab8_35e593e2c482
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:38
is: P24752
name: ACAT1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_e95f5999_2ee9_48fa_a4e7_b7ec39887403
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7086
constant: false
boundary condition: true
name: TKT
is: E7EPA7
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_d4555334_4501_4624_b6ca_0c8e1f38abe5
is encoded by: hsa:26275
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q6NVY1
name: HIBCH

metaM ser L e
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17115
name: L-serine
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
boundary condition: false
is: HMDB00187

metaM ppcoa m
type: Species
is: C00100
initial amount: NaN
name: Propanoyl-CoA
constant: false
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
boundary condition: false
is: CHEBI:57392
is: HMDB01275
is: SBO:0000247

metaR O2Stm
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#

metaR r0788
modifier: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_1c424459_a45a_4813_863a_a0adcf564fa3
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: PIP4K2B
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8396
boundary condition: true
is: P78356

metaM omhpal r
name: w-hydroxypalmiticacid
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB06294
initial amount: NaN
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
initial concentration: 1.0
type: Species

metaR FAOXC16OHC16r
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM h2o c
initial concentration: 1.0
initial amount: NaN
is: C00001
is: SBO:0000247
is: CHEBI:3303
type: Species
name: H2O
notes: FORMULA: H2O CHARGE: 0
boundary condition: false
is: HMDB02111
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_da4b6be4_8fa7_4b15_bf99_8e8e3bfe78a9
has only substance units: false
initial amount: NaN
is encoded by: hsa:55191
is: Q6IA69
name: NADSYN1
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR C6COAt
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d7765757_1f7a_438c_b169_5ad87f955f70
has only substance units: false
constant: false
is: SBO:0000252
is: D3DX95
initial concentration: NaN
name: CHAT
type: Species
boundary condition: true
is encoded by: hsa:1103
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_296699c4_f57c_433d_9df3_fefa5f07d661
is: Q7GXY8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4512
has only substance units: false
initial concentration: NaN
name: COX1
boundary condition: true
constant: false
type: Species

metaR Htm
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Uncoupling protein
notes: GENE_ASSOCIATION: (9016.1) or (7352.2) or (7352.1) or (7351.1) or (9016.2) or (7350.1) or (9481.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000269

metaR r0575
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110044#
type: Reaction

metaR r0789
modifier: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_98a0a201_2724_4833_bd11_4eb732041f49
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10327
boundary condition: true
name: AKR1A1

metaR 1PPDCRp
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
product: MODEL1310110044#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_d91070c2_b5de_4fae_9066_017e1e9b75e2
has only substance units: false
name: COX7A1
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:1346
is: P24310
is: SBO:0000252
boundary condition: true

metaR r0860
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
name: Utilized transport
reversible: true
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_491bc14c_d555_4570_b48d_367d50766fda
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80025
is: SBO:0000252
constant: false
name: PANK2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a8ab59cf_f7df_4aa2_9e26_984f64a5dcff
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:55907
is: SBO:0000252
initial concentration: NaN
is: Q8NFW8
name: CMAS
constant: false

metaM pail4p hs c
type: Species
initial concentration: 1.0
is: CHEBI:58178
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_3aec977f_078e_4c74_91ea_c3b8b2cb7c09
initial amount: NaN
is: SBO:0000297
type: Species
has only substance units: false
constant: false
is encoded by: hsa:23428
has part: Q86U05
boundary condition: true
name: SLC7A8:SLC3A2
initial concentration: NaN

metaR VALTAm
is described by: ECO:0000269
kinetic law: MODEL1310110044#
name: valine transaminase, mitochondiral
is: SBO:0000176
fast: false
reversible: true
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR r0973
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
is: SBO:0000185
name: Facilitated diffusion
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR THFtm
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
fast: false
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
product: MODEL1310110044#
is described by: ECO:0000000

metaM hexdicoa r
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
is: HMDB00672
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: hexadecanedioylcoa
boundary condition: false
constant: false

metaM pmtcrn x
initial concentration: 1.0
is: HMDB00222
has only substance units: false
is: SBO:0000247
is: CHEBI:17490
boundary condition: false
type: Species
initial amount: NaN
name: L-palmitoylcarnitine
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR CYTK9n
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP),nuclear
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110044#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_aed1b167_70e1_49ba_9626_993b7002cca1
initial amount: NaN
is: Q8TF71
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:117247
name: SLC16A10

metaR PHEt4
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-phenylalanine transport in via sodium symport
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
reversible: false
product: MODEL1310110044#

metaM HC02216 e
initial concentration: 1.0
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
type: Species
initial amount: NaN
name: prostaglandin-f2beta
constant: false
boundary condition: false
has only substance units: false

metaR r0633
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110044#
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110044#_9945ed4d_7236_49e1_be96_4cce4f74aeb3
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC6A8
is: SBO:0000252
is encoded by: hsa:6535
is: B4DIA3
type: Species
initial amount: NaN
constant: false

metaR CHOLt4
modifier: MODEL1310110044#
product: MODEL1310110044#
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
name: choline, sodium cotransport
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_befb43b4_fc09_4e44_b493_507873515d83
is: SBO:0000252
is: Q06203
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: PPAT
boundary condition: true
is encoded by: hsa:5471

metaM itp n
is: SBO:0000247
is: CHEBI:57614
has only substance units: false
constant: false
type: Species
is: HMDB00189
name: ITP(3-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

http://identifiers.org/biomodels.db/MODEL1310110044#_0c770f12_adcc_4506_92dd_fdde95817694
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q53Y25
type: Species
initial amount: NaN
is encoded by: hsa:2645
constant: false
name: GCK
is: SBO:0000252

metaM ser L c
name: L-serine
is: HMDB00187
boundary condition: false
type: Species
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17115
is: SBO:0000247

metaM leuktrD4 r
is: HMDB03080
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
type: Species
is: CHEBI:28666
name: Leukotriene D4
initial amount: NaN

metaM pram c
is: HMDB01128
is: SBO:0000247
is: C03090
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN
constant: false
name: 5-Phospho-beta-D-ribosylamine
initial concentration: 1.0
type: Species
is: CHEBI:58681
boundary condition: false
has only substance units: false

metaM HC01231 m
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58480
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079

metaR r0974
name: Active transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#

metaM leuktrA4 r
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
is: CHEBI:57463
name: leukotriene A4(1-)
is: SBO:0000247
is: HMDB01337
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaM hdca r
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:7896
type: Species
name: Hexadecanoate (n-C16:0)
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
initial concentration: 1.0
is: HMDB00220
is: C00249

metaR NDPK2
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110044#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:UDP)

http://identifiers.org/biomodels.db/MODEL1310110044#_ff839153_3e51_4e85_954f_f0421eb50731
is: Q9NWU1
constant: false
initial concentration: NaN
boundary condition: true
name: OXSM
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:54995

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR r0634
product: MODEL1310110044#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_62db5863_4450_4d0f_9b06_ed25438da314
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5230
has only substance units: false
is: SBO:0000252
is: P00558
type: Species
name: PGK1

http://identifiers.org/biomodels.db/MODEL1310110044#_ded2bc81_8c9a_4f46_be61_7338261a55c0
is encoded by: hsa:60490
initial concentration: NaN
name: PPCDC
constant: false
is: Q96CD2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_0f604e55_8dd0_4a85_a020_26167a5d0199
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SDHD
type: Species
is: O14521
boundary condition: true
is encoded by: hsa:6392
constant: false
has only substance units: false

metaR r0787
reversible: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
modifier: MODEL1310110044#

metaM focytC m
is: CHEBI:16928
name: Ferrocytochrome C
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_f9ef84ac_9d1d_4228_a0d9_df44776da0c7
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: PTGS1
is: SBO:0000252
is encoded by: hsa:5742
initial amount: NaN
is: P23219
has only substance units: false

metaR 5ADTSTSTERONEte
reversible: true
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
name: 5 alpha dihydrotesterone transport
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR CITRtm
reactant: MODEL1310110044#
is: SBO:0000185
fast: false
is described by: ECO:0000269
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: citrulline mitochondrial transport via proton antiport

metaM h2o e
initial amount: NaN
is: C00001
is: SBO:0000247
type: Species
is: HMDB02111
constant: false
is: CHEBI:15377
initial concentration: 1.0
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
has only substance units: false

metaR PHETHPTOX2
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is described by: ECO:0000269
modifier: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.14.16.1
product: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

metaR MGCHrm
kinetic law: MODEL1310110044#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
modifier: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
product: MODEL1310110044#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is: SBO:0000176

metaM sucsal m
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: CHEBI:57706
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01259
name: Succinic semialdehyde
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_4414381a_d242_4206_b34b_ecbb3c3a27ea
is: Q9NP56
boundary condition: true
is encoded by: hsa:27115
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: PDE7B

metaM pheacgln e
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06344
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247

metaR ACACt2
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: acetoacetate transport via proton symport
is described by: ECO:0000269
reversible: true

metaM 3otdcoa m
is: CHEBI:28726
initial amount: NaN
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB03935

metaR NDPK1
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP)
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000134
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_057a564a_7fe9_4c09_9a81_f83462f6367f
name: COX6C
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P09669
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:1345
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7f30bfae_6d0f_4a22_ab15_839f49ebd853
boundary condition: true
is: E5KNH5
initial amount: NaN
name: NDUFV1
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4723
initial concentration: NaN

metaM 4mzym int2 r
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: HMDB06838
initial concentration: 1.0
type: Species
name: 4-Methylzymosterol intermediate 2
boundary condition: false

metaR r0639
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000

metaR COAtn
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
name: coenzyme A transport, nuclear
reversible: true
is: SBO:0000185

metaR RE3347C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
name: RE3347
kinetic law: MODEL1310110044#
is: SBO:0000176

metaR r0784
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
kinetic law: MODEL1310110044#
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

metaM docohexcoa m
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: 2,4,7,10,13,16-docosahexenoylcoa

metaR RE0452M
is: SBO:0000176
fast: false
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: RE0452
reversible: true
is described by: ECO:0000000

metaM HC02216 c
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
name: prostaglandin-f2beta
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaM hdca l
has only substance units: false
initial concentration: 1.0
is: HMDB00220
is: SBO:0000247
initial amount: NaN
is: CHEBI:7896
constant: false
type: Species
name: palmitate
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110044#
reversible: true

metaR NDPK4
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dTDP)
is: SBO:0000176
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110044#

metaM ddcacoa m
type: Species
has only substance units: false
is: HMDB03571
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
is: C01832
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR CYTK9
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is: SBO:0000176
product: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP,dCTP)

metaR r1381
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5

http://identifiers.org/biomodels.db/MODEL1310110044#_6dfebbc0_7a93_4730_b6d3_24c8cf5aaa3a
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: P00414
is: SBO:0000252
initial amount: NaN
name: COX3
is encoded by: hsa:4514
has only substance units: false

metaR COAtm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
name: CoA transporter

http://identifiers.org/biomodels.db/MODEL1310110044#_22daf3e8_63a9_4c8c_89f3_001b4c8250a6
type: Species
initial amount: NaN
name: GMPS
is encoded by: hsa:8833
is: P49915
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaR ACOAO7p
reversible: false
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
fast: false
type: Reaction
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c16ff05c_47cf_43be_a5f2_5056d3308571
is: O00459
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5296
name: PIK3R2
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR r1380
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000176
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_bdb3b9af_4f04_46d6_9dc9_aae96328fbfd
is: SBO:0000252
name: SGPL1
is: O95470
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:8879
initial concentration: NaN
constant: false

metaR NDPK3
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:CDP)
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_256337a9_25cf_44b3_8f08_e70295d00f32
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:55350
boundary condition: true
constant: false
name: VNN3:VNN2:VNN1
is encoded by: hsa:8875
type: Species
has only substance units: false
has part: O95498
initial amount: NaN

metaM pheacgln c
has only substance units: false
initial concentration: 1.0
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
type: Species
is: HMDB06344
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM thbpt4acam c
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:15374
initial amount: NaN
is: HMDB02281
boundary condition: false
type: Species
name: 4a-hydroxytetrahydrobiopterin

metaM 4ppcys c
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
is: C04352
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01117
initial concentration: 1.0
is: CHEBI:59458
boundary condition: false

metaR CYTK8
product: MODEL1310110044#
reversible: true
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP)

http://identifiers.org/biomodels.db/MODEL1310110044#_2b8d0cd1_ac12_4c1d_9bd5_5afd8a440bd5
initial amount: NaN
is: P15104
has only substance units: false
is encoded by: hsa:2752
name: GLUL
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_dc751886_70ff_4707_8432_a3ff40698967
initial amount: NaN
is encoded by: hsa:1347
initial concentration: NaN
boundary condition: true
has only substance units: false
is: H0UI06
is: SBO:0000252
constant: false
name: COX7A2
type: Species

metaM CE5786 e
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
name: kinetensin
is: HMDB02710
type: Species
is: CHEBI:27485
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_95000866_db0b_4478_8a07_09d0f0603d1a
initial concentration: NaN
is: P32322
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: PYCR1
constant: false
is encoded by: hsa:5831
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_c325329d_38e5_4974_9773_460f7eca843c
is: SBO:0000252
is: P00374
constant: false
has only substance units: false
name: DHFR
type: Species
is encoded by: hsa:1719
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: coenzyme A transport, peroxisomal
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#

metaM fprica c
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
initial amount: NaN
is: HMDB01439
is: CHEBI:58467
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR DTMPK
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is: SBO:0000176
name: dTMP kinase
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
type: Reaction

metaM eitetcoa m
name: 5,8,11,14-eicosatetraenoylcoa
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR NDPK7
product: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP)
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR ALASm
type: Reaction
product: MODEL1310110044#
name: 5-aminolevulinate synthase
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
fast: false
is described by: ECO:0000254
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.29
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.37

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaM lys L m
is: CHEBI:32551
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00182
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

http://identifiers.org/biomodels.db/MODEL1310110044#_53b9dbe6_502d_40bb_b111_66db0c90df20
is encoded by: hsa:4713
is: P17568
name: NDUFB7
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_e0ab5f8f_0416_467b_b566_2888170a2e2c
initial amount: NaN
is encoded by: hsa:80271
boundary condition: true
is: SBO:0000252
is: Q96DU7
type: Species
name: ITPKC
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_eb0aabcf_2b69_4265_90b2_7c409c91b8e3
name: _100128062_1_m
is encoded by: hsa:100128062
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR BILGLCURtr
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaM prostgd2 r
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
constant: false
is: CHEBI:57406
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01403
has only substance units: false
name: prostaglandin D2(1-)

metaR CYTK7
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP)
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR r0638
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.8.1.2

http://identifiers.org/biomodels.db/MODEL1310110044#_7f9a6282_ac59_46d8_abb4_b8d1004c1ee4
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SUOX
is: SBO:0000252
initial amount: NaN
is: P51687
is encoded by: hsa:6821

metaM chol n
boundary condition: false
is: CHEBI:15354
constant: false
is: HMDB00097
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
is: SBO:0000247
name: choline
initial concentration: 1.0
has only substance units: false

metaM ala B c
is: SBO:0000247
has only substance units: false
is: HMDB00056
boundary condition: false
constant: false
name: beta-alanine
initial amount: NaN
type: Species
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0

metaR BALAVECSEC
reactant: MODEL1310110044#
is: SBO:0000185
reversible: false
name: B-alanine secretion via secretory vesicle (ATP driven)
fast: false
notes: GENE_ASSOCIATION: (140679.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750892,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known for sure stoichiometrically, but 1:1 H coupling ratio is assumed, which could translate to 3 b-ala/ATP.
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110044#

metaR r1301
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Vesicular transport
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR Htg
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#

metaM sphmyln hs c
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: sphingomyelin betaine
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:58216

metaR FMNAT
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.7.2
kinetic law: MODEL1310110044#
name: FMN adenylyltransferase
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false

metaM 25aics c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: C04823
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: CHEBI:58443
boundary condition: false
initial amount: NaN
is: HMDB00797
constant: false

metaR NDPK6
product: MODEL1310110044#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
fast: false
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaR r0783
reversible: true
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
type: Reaction
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
modifier: MODEL1310110044#
is: SBO:0000176

metaR NDPK5
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_58fe68c1_3248_4c35_bcd4_ba757486e543
constant: false
is: P49327
boundary condition: true
is encoded by: hsa:2194
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: FASN
initial amount: NaN

metaR r0926
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
fast: false
kinetic law: MODEL1310110044#
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110044#

metaM dgchol e
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
is: HMDB00637
is: CHEBI:36252
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR LTC4CP
reactant: MODEL1310110044#
is: SBO:0000176
name: Leukotriene C4 carboxypeptidase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#

metaM CE5119 m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:57923
name: trans-3-cis-8-tetradecadienoyl-CoA

metaR CYTK6
product: MODEL1310110044#
reversible: true
fast: false
name: cytidylate kinase (CMP,CTP)
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_2dfb8e91_e540_48e2_b88f_703e6516d359
is encoded by: hsa:8140
is: Q8IV97
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC7A5

metaR r1661
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR DNDPt8m
is: SBO:0000185
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
fast: false
name: dADP transport via dUDP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_2df0d2d0_ce83_4528_817d_57794468b03c
initial amount: NaN
boundary condition: true
name: VNN3
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN

metaM 5eipencoa m
initial amount: NaN
name: 5,8,11,14,17-eicosapentenoylcoa
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110044#
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR DCYTDn
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
reversible: false
modifier: MODEL1310110044#
name: deoxycytidine deaminase, nuclear
product: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
type: Reaction

metaM i c
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
initial concentration: 1.0
type: Species
is: HMDB12238
has only substance units: false
name: iodide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_75b8feb4_ea73_4c1a_a547_8e014174b054
is encoded by: hsa:8836
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q92820
name: GGH
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_3f6d0ae9_addc_4218_aef5_9e62dc5c7409
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:23305
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ACSL6
is: B2RB13

metaR NDPK9
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
fast: false
is: SBO:0000176
modifier: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:IDP)
reversible: true

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_ae372987_5c7e_4e76_a886_e17a4308b364
is encoded by: hsa:34
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ACADM
boundary condition: true
is: P11310
is: SBO:0000252

metaM strdnccoa c
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205473
has only substance units: false
is: C16163
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
name: stearidonyl coenzyme A
is: SBO:0000247
is: HMDB06519

metaR DCK1n
fast: false
product: MODEL1310110044#
name: Deoxycytidine kinase, nuclear (ATP)
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a186324e_7dea_4bbd_9ac5_4f5b3451a292
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9HCC0
is encoded by: hsa:64087
constant: false
name: MCCC2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_2e10cd7d_afd5_4120_923b_2bf787fbd997
is: SBO:0000252
name: NOS1
is encoded by: hsa:4842
constant: false
initial concentration: NaN
is: B4DG68
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c9135635_9a8a_45d3_90bc_c6535efd10c8
is: Q9NUB1
is: SBO:0000252
name: ACSS1
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:84532
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_19d76fe1_50f6_43d6_86b8_4e91f46ad72b
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6470
is: P34896
has only substance units: false
type: Species
constant: false
name: SHMT1
initial amount: NaN
is: SBO:0000252

metaM prostgh2 e
boundary condition: false
initial amount: NaN
constant: false
name: prostaglandin H2(1-)
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381
has only substance units: false
is: CHEBI:57405

http://identifiers.org/biomodels.db/MODEL1310110044#_889b76fe_efee_479c_8d72_81f5f1547b8a
initial amount: NaN
is: O14734
name: ACOT8
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:10005
boundary condition: true

metaR G6Pter
is described by: ECO:0000269
reactant: MODEL1310110044#
type: Reaction
reversible: true
modifier: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_3b751700_e140_4082_8849_fe5dff473de1
name: ACOT8
is encoded by: hsa:10005
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: O14734
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_6c9d6600_b9c2_4070_a3fd_7a9587b8d6fa
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _D87002_1_e
type: Species
constant: false
is encoded by: hsa:D87002
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_236fc250_e805_4e0a_9f4f_2a2d037772c2
is encoded by: hsa:51166
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: AADAT
has only substance units: false
is: SBO:0000252
is: Q4W5N8

metaR r1662
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR CYTK4
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
fast: false
name: cytidylate kinase (dCMP)(GTP)
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
is: SBO:0000176

metaR RE1531M
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110044#
name: RE1531
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_52556a26_01c8_47c2_8878_8226860ea27d
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5330
has only substance units: false
is: Q59F77
name: PLCB2
type: Species
initial concentration: NaN

metaM spc hs c
name: sphingosylphosphorylcholine
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM acnam n
initial amount: NaN
initial concentration: 1.0
is: HMDB00230
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: CHEBI:35418
name: N-acetylneuraminate
boundary condition: false
type: Species
constant: false

metaR NDPK8
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dADP)
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
reactant: MODEL1310110044#
fast: false
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR ALOX52
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is: SBO:0000176
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.13.11.34
is described by: ECO:0000269
name: Arachidonate 5-lipoxygenase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_5dc759f3_8ff4_47c2_a967_47c634640a4b
has only substance units: false
is encoded by: hsa:84706
type: Species
initial concentration: NaN
name: GPT2
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q8TD30

http://identifiers.org/biomodels.db/MODEL1310110044#_4a78a31b_da52_42ce_8760_77ea3494b8a8
boundary condition: true
is encoded by: hsa:6513
is: SBO:0000252
name: SLC2A1
initial concentration: NaN
is: P11166
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_98681615_4005_4e90_93b7_39fa8203f707
is encoded by: hsa:7108
boundary condition: true
is: O76062
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: TM7SF2
has only substance units: false

metaR r0129
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
type: Reaction
is: SBO:0000176

metaR CYTK3
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
name: cytidylate kinase (CMP)(GTP)
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110044#_c49057a5_3a79_4ba5_a319_b165e07c736e
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: _AI915649_1_c
is: SBO:0000252
is encoded by: hsa:AI915649

metaM ppcoa x
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01275
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
type: Species
initial concentration: 1.0
is: C00100
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110044#_3772cc8f_b910_4740_a501_6f430722501b
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:55350
is: SBO:0000252
constant: false
name: VNN3
type: Species
initial amount: NaN

metaM CE4872 m
constant: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
has only substance units: false
type: Species
is: HMDB00127
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
is: CHEBI:15748

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c0480ca9_be6a_46ec_9615_4918ab5764f2
is: SBO:0000252
has only substance units: false
name: SLC6A10P
constant: false
is encoded by: hsa:386757
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaM pail4p hs n
is: CHEBI:58178
constant: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false

metaM pro D c
type: Species
initial concentration: 1.0
is: HMDB03411
is: SBO:0000247
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
is: CHEBI:16313
boundary condition: false
has only substance units: false
initial amount: NaN

metaR FADH2tru
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_1eaf952b_c45f_41b4_9080_3172eff1acf8
is: SBO:0000252
is encoded by: hsa:55089
constant: false
boundary condition: true
is: Q969I6
initial amount: NaN
type: Species
has only substance units: false
name: SLC38A4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_56ea02ab_f41b_4cc7_b8c7_766e4715717c
name: ALDH3A2
is: P51648
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:224
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_235feb34_a60d_4fe2_836a_d511f4e9380d
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is: E9PB82
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3295
name: HSD17B4

metaM asp D x
is: SBO:0000247
initial amount: NaN
name: D-aspartate(1-)
type: Species
is: CHEBI:29990
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
boundary condition: false
initial concentration: 1.0
is: HMDB06483
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b40b3a59_207b_45ca_b778_dcf18eafb49d
constant: false
is: B3KT19
is: SBO:0000252
is encoded by: hsa:5295
type: Species
name: PIK3R1
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

MODEL1310110044
species: metaM nad x
reaction: metaR r0595
species: metaM 4ppan c
reaction: metaR r0287
reaction: metaR r2322
reaction: metaR PAIL45P HStn
species: metaM 34hpp e
reaction: metaR EX 3mop LPAREN e RPAREN
reaction: metaR r1400
reaction: metaR r2364
species: metaM pail45p hs c
reaction: metaR r0422
reaction: metaR r2379
species: metaM 1pyr5c c
species: metaM e4hglu m
reaction: metaR r0672
reaction: metaR RIBt
species: metaM oh1 e
reaction: metaR RE2269E
species: metaM prostgh2 e
reaction: metaR r0480
reaction: metaR PACCOAL
species: metaM HC01115 c
reaction: metaR r1612
reaction: metaR EX lnlncg LPAREN e RPAREN
reaction: metaR UDPGLCAter
reaction: metaR r0522
reaction: metaR RDH3
reaction: metaR r0999
reaction: metaR ARGtm
species: metaM chsterol r
reaction: metaR UGT1A5r2
reaction: metaR LEUt5m
reaction: metaR DTDPtn
species: metaM focytC m
species: metaM din c
reaction: metaR METtec
reaction: metaR GLYSNAT5tc
species: metaM dd3coa x
species: metaM 56dthm c
reaction: metaR UNK2
reaction: metaR L LACt2r
reaction: metaR r1018
species: metaM odecoa c
reaction: metaR EX HC01609 LPAREN e RPAREN
reaction: metaR r1495
reaction: metaR KCCt
reaction: metaR ACS
species: metaM asp D e
species: metaM glu5sa m
reaction: metaR r2361
reaction: metaR PI4PLC
reaction: metaR P5CRxm
reaction: metaR GLYCTDle
species: metaM HC02206 c
species: metaM mev R c
reaction: metaR r0791
reaction: metaR FTHFL
reaction: metaR LNLCCPT2
reaction: metaR FAOXC226C205m
reaction: metaR r0984
reaction: metaR r2107
reaction: metaR FADH2tru
reaction: metaR 34DHXMANDACOX NADP
species: metaM co2 e
species: metaM cmp e
reaction: metaR EX dtdp LPAREN e RPAREN
reaction: metaR CYTK2n
species: metaM cyan c
reaction: metaR MI1PP
reaction: metaR 1PPDCRp
species: metaM gthrd e
reaction: metaR FAOXC121C10x
reaction: metaR UMPK6n
species: metaM CE2421 m
reaction: metaR SRTNt6 2 r
species: metaM ser D e
species: metaM retn r
reaction: metaR r1418
reaction: metaR r2506

metaM adpcoa x
type: Species
is: C14143
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
boundary condition: false
initial amount: NaN
is: HMDB04047
constant: false
has only substance units: false
initial concentration: 1.0
name: adipoylcoa
is: SBO:0000247

metaR CYTK2
modifier: MODEL1310110044#
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_8782e67f_1006_4b01_be50_0806f75c6810
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: P51828
initial concentration: NaN
boundary condition: true
name: ADCY7
is encoded by: hsa:113

http://identifiers.org/biomodels.db/MODEL1310110044#_5a5aca9b_0638_4857_b975_11c023bbf97c
is: P28331
has only substance units: false
is encoded by: hsa:4719
type: Species
name: NDUFS1
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_9d5be6a9_9f89_42c2_b7e2_bee01c3c9551
type: Species
has only substance units: false
name: MPI
initial concentration: NaN
is: P34949
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4351

metaM 34dhphe c
is: HMDB00181
is: SBO:0000247
is: CHEBI:15765
initial amount: NaN
type: Species
initial concentration: 1.0
name: L-dopa
constant: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
has only substance units: false

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM pmtcrn r
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
initial concentration: 1.0
has only substance units: false
is: HMDB00222
is: CHEBI:17490
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_ab3bf549_01b9_40ef_bae3_c6f79cee39fd
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: ABAT
initial concentration: NaN
is encoded by: hsa:18

metaR HSD3A2r
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_a9f6ba27_a619_44dd_bc35_95c0a80c8a24
name: SLC38A5
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q8WUX1
is encoded by: hsa:92745
is: SBO:0000252
has only substance units: false

metaM 4ppcys m
is: CHEBI:59458
initial amount: NaN
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
is: HMDB01117

metaM itp e
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
name: ITP(3-)
constant: false
is: HMDB00189
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR DITPtn
name: dITP nuclear transport
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_fd3e4b93_3dca_447b_8c01_aa9362de359c
is: Q15274
constant: false
boundary condition: true
is encoded by: hsa:23475
initial concentration: NaN
is: SBO:0000252
type: Species
name: QPRT
has only substance units: false
initial amount: NaN

metaM spc hs e
has only substance units: false
is: http://identifiers.org/pubchem.compound/5311445
name: sphingosylphosphorylcholine
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR r2435
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

metaR r1664
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_b2ac5550_6e14_4bd0_be62_c090398f189d
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: PIK3CD
is: A7E2E0
constant: false
initial amount: NaN
is encoded by: hsa:5293

metaR CYTK1
name: cytidylate kinase (CMP)
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR THMDt4
name: thymidine transport in via sodium symport
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_14a6803d_2666_4c17_b902_33106b31ba1f
is: P22413
is: SBO:0000252
is encoded by: hsa:5167
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: ENPP1
constant: false
initial concentration: NaN

metaR ACt2r
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
name: acetate reversible transport via proton symport
reactant: MODEL1310110044#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_0dc956c4_6eae_4faa_a3f4_8a6cab207c15
boundary condition: true
constant: false
is encoded by: hsa:NOS2A
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _NOS2A_1_c
type: Species
is: SBO:0000252

metaR PRO1xm
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
is: SBO:0000176
reversible: false
name: proline oxidase (NAD), mitochondrial
modifier: MODEL1310110044#
is described by: ECO:0000254
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.99.8
fast: false

metaR r0354
reversible: false
reactant: MODEL1310110044#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR r1435
reactant: MODEL1310110044#
fast: false
name: Transport reaction
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#

metaR LYStm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
is: SBO:0000185
name: Lysine mitochondrial transport via ornithine carrier
product: MODEL1310110044#
is described by: ECO:0000269

metaM 2mcit c
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
type: Species
is: HMDB00379
boundary condition: false
constant: false
is: CHEBI:15598
is: SBO:0000247
name: 2-methylcitrate(3-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR GARFT
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110044#
name: phosphoribosylglycinamide formyltransferase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110044#
type: Reaction

metaM lys L c
is: SBO:0000247
initial concentration: 1.0
constant: false
name: L-lysinium(1+)
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:32551
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN

metaR APAT2rm
is: SBO:0000176
kinetic law: MODEL1310110044#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
modifier: MODEL1310110044#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
type: Reaction
is described by: ECO:0000212

metaR RE0512M
product: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE0512
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_5f7bf475_07a3_4bfb_af26_18c0ec734d2b
initial amount: NaN
boundary condition: true
is: P47989
is encoded by: hsa:7498
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: XDH

metaM 34dhphe e
initial amount: NaN
is: CHEBI:15765
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
name: L-dopa
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB00181

metaM r1p c
is: SBO:0000247
initial amount: NaN
is: C00442
boundary condition: false
is: CHEBI:57720
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
has only substance units: false
is: HMDB01489
type: Species
name: alpha-D-Ribose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110044#_2c74d4ac_b5fe_4c82_b900_c3dcd4a8c5b4
type: Species
is: F8WDN9
initial concentration: NaN
constant: false
is encoded by: hsa:27068
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PPA2

metaM so3 c
is: SBO:0000247
initial amount: NaN
is: CHEBI:17137
has only substance units: false
boundary condition: false
is: HMDB00240
is: C00094
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: Sulfite
initial concentration: 1.0
type: Species

metaR HIStiDF
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
is described by: ECO:0000269
name: L-histidine transport via diffusion (extracellular to cytosol)

metaR Htr
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: H transporter, endoplasmic reticulum
product: MODEL1310110044#

metaR RE3004M
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: RE3004
is: SBO:0000176
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR r0355
fast: false
product: MODEL1310110044#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110044#_8d9ec6d7_1475_4460_a5c6_5cda14453ee2
name: NOS3
is encoded by: hsa:4846
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: A0S0A7
is: SBO:0000252
has only substance units: false

metaM 44mctr r
initial amount: NaN
is: CHEBI:17813
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
type: Species
is: HMDB01023
constant: false
initial concentration: 1.0

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR 3MOPt2im
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185

metaM co2 e
is: C00011
name: CO2
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
type: Species

metaM cmp e
initial amount: NaN
boundary condition: false
name: CMP(2-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
is: CHEBI:60377
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_5422b67a_8dd1_4413_91f4_a1330d1636ac
constant: false
boundary condition: true
name: _H53099_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:H53099
initial concentration: NaN
type: Species
is: SBO:0000252

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM HC01609 e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:28766
name: UroporphyrinogenI
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
type: Species
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_2bb1252d_110c_444b_982d_af43b117e9ee
initial amount: NaN
name: MTHFD2L
initial concentration: NaN
is encoded by: hsa:441024
constant: false
is: SBO:0000252
has only substance units: false
is: Q9H903
type: Species
boundary condition: true

metaM prostgh2 c
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57405
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381
name: prostaglandin H2(1-)

http://identifiers.org/biomodels.db/MODEL1310110044#_86d3fa8a_a95c_4d48_a593_dbb5a98853af
initial amount: NaN
type: Species
name: FOLR1
is encoded by: hsa:2348
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM ddcacoa x
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
initial amount: NaN
is: HMDB03571
has only substance units: false
is: SBO:0000247
is: C01832
type: Species
boundary condition: false
is: CHEBI:57375

metaR CHOLK
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
is: SBO:0000176
type: Reaction
name: Choline kinase

metaM 2mcit e
initial concentration: 1.0
type: Species
is: HMDB00379
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15598
initial amount: NaN
name: 2-methylcitrate(3-)
has only substance units: false

metaM lys L e
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
initial concentration: 1.0
name: L-lysinium(1+)
boundary condition: false
type: Species
is: CHEBI:32551
has only substance units: false
is: HMDB00182
initial amount: NaN
is: SBO:0000247

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_2ce2ed99_8eee_4bb3_9ef5_91de449a2c4c
is: G3V0F6
has only substance units: false
initial concentration: NaN
name: DGKZ
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:8525

metaM CE2839 e
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
constant: false
name: maltodecaose
is: C01936
has only substance units: false

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
name: RE0926
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
is: SBO:0000176
reversible: true

metaR CRNrtx
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: reversible transport of L-Carnitine in peroxisome
is described by: ECO:0000134
product: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_74d2fa1c_cd98_4285_bdd0_832470bf2ceb
has only substance units: false
is encoded by: hsa:1892
constant: false
is: SBO:0000252
is: P30084
type: Species
name: ECHS1
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r1660
reversible: true
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
type: Reaction

metaR HIStN1
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: Histidine transport (Na, H coupled)
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_b324b4bb_16e3_4d8d_94d3_b423142b26b6
is: E7EML0
has only substance units: false
type: Species
name: SLC4A8
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:9498
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_d34a9773_9452_4244_8832_7d5a937d5ae8
boundary condition: true
is: Q14542
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC29A2
is encoded by: hsa:3177

metaM thbpt4acam n
initial concentration: 1.0
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
has only substance units: false
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
is: HMDB02281
is: CHEBI:15374
type: Species
constant: false
initial amount: NaN

metaR GLCt1r
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
modifier: MODEL1310110044#
is: SBO:0000185
reversible: true
name: glucose transport (uniport)
is described by: ECO:0000269
type: Reaction

metaM CE5236 n
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB03952
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: CHEBI:28002
initial concentration: 1.0

metaM co2 c
is: HMDB01967
is: C00011
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: CO2
notes: FORMULA: CO2 CHARGE: 0
type: Species
is: CHEBI:3313

metaM cmp c
is: C00055
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: HMDB00095
name: CMP
constant: false
is: CHEBI:60377
type: Species

metaM ile L m
is: CHEBI:17191
constant: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
boundary condition: false
name: L-isoleucine
is: HMDB00172
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r0630
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000176
reversible: true

metaR r2367
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_db2a639f_5eb0_47ba_9430_24225696ea68
name: SLC24A3
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9HC58
is encoded by: hsa:57419
initial amount: NaN

metaM dd2coa m
constant: false
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
is: CHEBI:57330
has only substance units: false
type: Species
name: trans-dodec-2-enoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110044#_7d3fb5e6_9e26_4936_a7ff_bb5da39695aa
boundary condition: true
is encoded by: hsa:AV713053
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: _AV713053_1_m
initial amount: NaN
initial concentration: NaN

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r1993
reversible: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#

metaR r2088
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_3e43d0f7_426d_40d5_bf2b_01db466b3917
has only substance units: false
name: _AU149534_1_c
boundary condition: true
initial amount: NaN
is encoded by: hsa:AU149534
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaM ocde9ecoa x
initial concentration: 1.0
name: 9-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_43c78759_6fc7_4d02_ac98_5349edbba8da
type: Species
is encoded by: hsa:6526
initial concentration: NaN
is: SBO:0000252
name: SLC5A3
initial amount: NaN
is: P53794
has only substance units: false
constant: false
boundary condition: true

metaM pmtcrn m
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
is: HMDB00222
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17490
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c3e51682_0758_4ec2_a7ad_b15eb9ab0ed3
is: SBO:0000252
boundary condition: true
is: B4DUY1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: STARD3
is encoded by: hsa:10948
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_e9077cdf_6bf9_488b_b5c2_0f7936cc7705
type: Species
is: B3KT70
has only substance units: false
name: HKDC1
initial amount: NaN
is encoded by: hsa:80201
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r0424
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_c40a4af2_784c_4555_ba0e_48a4ea0a406a
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:642502
name: _642502_1_c
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r0317
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.10
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction

metaR GGH 7DHFe
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is described by: ECO:0000000
product: MODEL1310110044#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176

metaR r1668
reversible: true
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
modifier: MODEL1310110044#

metaR ORETNF
name: 4-oxo-retinoic acid formation (oxidation)
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR r1914
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000

metaM o2 r
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01377
boundary condition: false
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: C00007
type: Species
initial amount: NaN

metaM succ c
has only substance units: false
is: SBO:0000247
is: HMDB00254
initial concentration: 1.0
initial amount: NaN
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
is: CHEBI:30031
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_3659cc26_2de7_4d42_be66_32dd12a1d4ec
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5337
is: Q59EA4
constant: false
is: SBO:0000252
name: PLD1

metaR ALDD2xm
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000134
product: MODEL1310110044#
fast: false

metaM CE2420 m
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: CHEBI:28387
boundary condition: false
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaM h2o2 c
is: CHEBI:16240
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB03125
is: SBO:0000247
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
boundary condition: false
constant: false
type: Species

metaR 34DHPLACOX NADP
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
fast: false
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR 2HBO
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is described by: ECO:0000269
fast: false
product: MODEL1310110044#
is: SBO:0000176
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD

metaR r2366
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaM zym int2 r
is: SBO:0000247
is: CHEBI:52386
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
initial concentration: 1.0
name: zymosterol intermediate 2

metaR r1453
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:

metaR RNDR4
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
modifier: MODEL1310110044#
name: ribonucleoside-diphosphate reductase (UDP)
is described by: ECO:0000254
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176

metaR r2087
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_ca238258_2e91_40d3_a116_61aee5b75fee
initial concentration: NaN
is: Q9BZX2
name: UCK2
constant: false
is encoded by: hsa:7371
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaR r2344
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true

metaR DNDPt23m
fast: false
reversible: false
product: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000269
name: dTDP transport via dGTP antiport
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r0181
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110044#

metaR PRASCS
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.3.2.6
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000176
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
reactant: MODEL1310110044#

metaR UMPK5n
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: UMP kinase (dATP),nuclear
product: MODEL1310110044#

metaR 3MOX4HOXPGALDOX NADP
fast: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_64bd47a1_c9c3_48a7_aec1_45b86797c149
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AA614647
name: _AA614647_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM clpndcoa c
is: HMDB06267
boundary condition: false
is: C16166
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: http://identifiers.org/pubchem.compound/47205476
constant: false
initial concentration: 1.0
initial amount: NaN
name: clupanodonyl CoA
has only substance units: false
type: Species

metaR PHCDm
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_20d4d55b_a221_4466_96d2_2dfd93516fe1
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: PKLR
is encoded by: hsa:5313
is: P30613
boundary condition: true
is: SBO:0000252
constant: false

metaR r0423
type: Reaction
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#

metaM 5adtststerones c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06278

metaR r1667
reversible: true
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_3dc40a5b_227b_46fe_8158_253ef906d02d
is encoded by: hsa:2882
is: Q96SL4
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GPX7
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

metaR DOPAt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is: SBO:0000185
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM ptth m
is: CHEBI:16753
has only substance units: false
name: pantetheine
boundary condition: false
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
is: HMDB03426
initial concentration: 1.0
constant: false
initial amount: NaN

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_1e9045fb_673d_44d1_842a_a163c1d6feae
initial concentration: NaN
is encoded by: hsa:5286
constant: false
name: PIK3C2A
type: Species
initial amount: NaN
boundary condition: true
is: O00443
is: SBO:0000252
has only substance units: false

metaR RNDR1
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000254
reversible: false
reactant: MODEL1310110044#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_fe922dd0_c686_4bdf_aa4d_180c46fe7508
initial concentration: NaN
name: COX7B2
type: Species
is: Q8TF08
is encoded by: hsa:170712
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_8d3e681e_4942_494c_8919_50f04033857f
constant: false
name: GMPR2
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51292

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR LEUKTRE4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: leukotriene E4 transport
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_b6931319_031c_4401_9cd3_4295afdf5189
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q92947
is: SBO:0000252
constant: false
name: GCDH
is encoded by: hsa:2639

metaR r1995
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is: SBO:0000185
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
type: Reaction

metaM tetdecdicoa m
name: 5,8-tetradecadienoylcoa
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02288
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_408391af_5172_4e1f_a54a_bd7455a5a166
boundary condition: true
is encoded by: hsa:55902
is: Q5QPH3
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: ACSS2

metaR KCCt
reactant: MODEL1310110044#
product: MODEL1310110044#
name: K+-Cl- cotransport
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
modifier: MODEL1310110044#
type: Reaction
reversible: true

metaR FAOXC14C12x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR r0426
modifier: MODEL1310110044#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reactant: MODEL1310110044#
fast: false

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
initial concentration: 1.0
is: CHEBI:28387
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB11123
constant: false

metaR 5MTHFt2le
name: 5-methyltetrahydrofolate transport via anion exchange
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM gtp m
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
initial amount: NaN
constant: false
name: GTP
is: C00044
is: CHEBI:37565
is: HMDB01273
is: SBO:0000247
has only substance units: false

metaR r2369
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110044#
reversible: true
fast: false
reactant: MODEL1310110044#

metaR r1666
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
modifier: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
name: Y+LAT2 Utilized transport

metaR FAOXC227C226m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_ab5ee429_05c7_4cb2_b1db_f13d1b10f173
initial concentration: NaN
name: _AI631997_1_m
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:AI631997
is: SBO:0000252
constant: false
has only substance units: false

metaR r1451
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
name: EC:1.3.3.6
is: SBO:0000176
reversible: false

metaM din e
is: C05512
initial amount: NaN
has only substance units: false
name: Deoxyinosine
is: HMDB00071
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
constant: false
is: CHEBI:28997
initial concentration: 1.0

metaM h2o2 e
initial concentration: 1.0
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
has only substance units: false
name: hydrogen peroxide
constant: false
is: CHEBI:16240
initial amount: NaN
type: Species
boundary condition: false

metaM CE5236 c
name: O2'-4a-cyclic-tetrahydrobiopterin
is: SBO:0000247
has only substance units: false
is: CHEBI:28002
boundary condition: false
initial amount: NaN
is: HMDB03952
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0513800c_bcb8_4205_ae46_14ced2b27289
type: Species
boundary condition: true
is encoded by: hsa:2348
initial amount: NaN
name: FOLR1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r2089
is: SBO:0000185
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_59e8f072_947f_42ad_a824_1912005077a4
has only substance units: false
name: NDUFS4
is: O43181
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:4724

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR BTNt4i
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
name: Biotin uptake (antiport)
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR r1994
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#

metaR r0425
is described by: ECO:0000000
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.17.1.4
name: EC:1.1.1.42
type: Reaction
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:

metaM gtp n
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: CHEBI:37565
is: HMDB01273
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: GTP(4-)

metaR r2368
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110044#
is: SBO:0000185

metaR r1665
reversible: true
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
fast: false

metaR GLUtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
product: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000185
name: intracellular transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM 5adtststerones e
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB06278
constant: false

metaR r2341
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reversible: true

metaM leuktrC4 e
has only substance units: false
name: leukotriene C4(2-)
boundary condition: false
type: Species
constant: false
is: HMDB01198
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM 1p3h5c m
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false
type: Species
is: CHEBI:6151
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false
is: SBO:0000247

metaR r2363
product: MODEL1310110044#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false

metaM 13 cis retnglc c
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1
name: 13-cis-retinoyl glucuronide
is: HMDB03141
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:28870

metaM CE4790 m
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
type: Species
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR r2419
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c8160944_9342_45f7_a4c4_476e86003205
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4694
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q6IBB5
has only substance units: false
name: NDUFA1

metaM odecoa c
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
boundary condition: false
is: HMDB01322
initial amount: NaN
is: CHEBI:3793
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247

metaM hmgcoa x
is: HMDB01375
boundary condition: false
initial amount: NaN
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaR GGH 7THFe
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
name: Gamma-glutamyl hydrolase (7THF), extracellular
is described by: ECO:0000000
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110044#_2521e099_5339_46be_b5e5_59281bbbe6b2
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA532636
is: SBO:0000252
constant: false
name: _AA532636_1_m
has only substance units: false
initial amount: NaN

metaR GLNtm
reversible: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
type: Reaction
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000
product: MODEL1310110044#

metaR TTDCAtr
fast: false
name: tetradecanoate (transport)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
product: MODEL1310110044#
type: Reaction
is: SBO:0000185

metaR PE HStm
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
fast: false
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110044#

metaM L2aadp m
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00510
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
is: SBO:0000247
name: L-2-aminoadipate(1-)

http://identifiers.org/biomodels.db/MODEL1310110044#_01364568_e37c_4b50_95b1_d5e94bf706e3
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: O60760
is encoded by: hsa:27306
has only substance units: false
name: HPGDS
initial amount: NaN
is: SBO:0000252

metaR RE3050R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is described by: ECO:0000000
reversible: true
name: RE3050
fast: false
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_57c1dfbb_4e28_47fc_8bad_68ea651fe102
type: Species
name: PIK3CG
boundary condition: true
is encoded by: hsa:5294
constant: false
is: P48736
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR RE3326M
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
is: SBO:0000176
type: Reaction
name: RE3326
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
modifier: MODEL1310110044#

metaR BILIRUBtr
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reversible: true
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR RE0344C
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
name: RE0344
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

metaM din c
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00071
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
boundary condition: false
name: Deoxyinosine

http://identifiers.org/biomodels.db/MODEL1310110044#_035949c9_d0b5_4e62_a3b8_5bff146827ec
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10449
is: P42765
name: ACAA2
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r2362
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
product: MODEL1310110044#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM HC02205 c
initial amount: NaN
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: prostaglandin-b2
is: CHEBI:28099
initial concentration: 1.0

metaR r1109
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:

metaM 2docohexecoa m
name: 2,7,10,13,16,19-docosahexenoylcoa
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM tdchola c
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
name: taurochenodeoxycholate
is: CHEBI:9407
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR DHCR72r
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000269
is: SBO:0000176
fast: false
reversible: false
name: 7-dehydrocholesterol reductase
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR r1919
fast: false
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
modifier: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#

metaM thp2c c
is: HMDB12130
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: 1-piperideine-6-carboxylate

metaM strdnc e
is: SBO:0000247
type: Species
constant: false
is: C16300
is: HMDB06547
is: http://identifiers.org/pubchem.compound/47205608
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
name: stearidonic acid C18:4, n-3

metaM amet c
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
is: CHEBI:15414
name: S-Adenosyl-L-methionine
boundary condition: false
initial amount: NaN
is: C00019
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

metaR r1996
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaR FRDPtr
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
reversible: true

metaM cys L c
initial concentration: 1.0
name: L-cysteine
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
has only substance units: false
is: HMDB00574
initial amount: NaN
type: Species
constant: false
is: CHEBI:17561

metaR ORNtiDF
reversible: false
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110044#
is described by: ECO:0000269
name: ornithine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR OBDHc
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
name: 2-Oxobutanoate dehydrogenase, cytosolic

metaR r2365
product: MODEL1310110044#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110044#_05cbd875_5a24_43d3_b562_407407e42355
is encoded by: hsa:79646
has only substance units: false
constant: false
type: Species
boundary condition: true
is: Q9H999
initial amount: NaN
name: PANK3
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_7c5c109f_f73b_41f2_92e7_042b439d2e1b
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AMY1C
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: P04745
is encoded by: hsa:278

metaR r0311
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
type: Reaction
reversible: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110044#_897b8406_70b7_4d6b_9970_3414da1e778d
is: P24298
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GPT
is encoded by: hsa:2875
type: Species

metaM 13 cis retnglc e
name: 13-cis-retinoyl glucuronide
constant: false
boundary condition: false
is: CHEBI:28870
initial amount: NaN
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB03141

metaR r1456
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110044#
is: SBO:0000185
fast: false
name: Transport reaction
reversible: false
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110044#

metaM succoa m
initial amount: NaN
is: CHEBI:57292
is: HMDB01022
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Succinyl-CoA
type: Species
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247

metaM pe hs m
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial amount: NaN
has only substance units: false
name: phosphatidylethanolamine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaR r0422
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
fast: false
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR r1999
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: false
is: SBO:0000185
product: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110044#

metaR FAOXC102C81m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
name: deoxycytidine transport via diffusion
reversible: true
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_f6c9a15e_2b42_490e_889b_3aeafdd6e75a
is: SBO:0000297
is encoded by: hsa:23428
constant: false
has only substance units: false
name: SLC7A8:SLC3A2
boundary condition: true
initial concentration: NaN
has part: Q9UHI5
type: Species
initial amount: NaN

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:28099
boundary condition: false
name: prostaglandin-b2
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9f6fd0e0_ddf7_4938_8fa1_e90741c849fd
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: _AL038231_1_c
is encoded by: hsa:AL038231
is: SBO:0000252
type: Species

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR r2364
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#

metaR r0310
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0b7f5425_358d_4bc2_a449_ac3e6a4aec57
is: H0YMZ7
initial concentration: NaN
is encoded by: hsa:5151
constant: false
name: PDE8A
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r1455
fast: false
is described by: ECO:0000000
type: Reaction
name: Transport reaction
reversible: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_8e2a046f_bb2c_4b3e_b9f4_27c464275e19
initial amount: NaN
is encoded by: hsa:314
constant: false
name: AOC2
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM o2 m
initial concentration: 1.0
is: C00007
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
initial amount: NaN
type: Species
is: CHEBI:15379
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01377

metaM tdchola e
initial amount: NaN
has only substance units: false
is: HMDB00951
type: Species
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
is: CHEBI:9407
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_88310127_8f03_4180_b4a6_70e41bd0f47a
is: Q9P0J0
initial amount: NaN
is encoded by: hsa:51079
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFA13
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_cc23d71d_2d9e_4920_8264_fa19df1d42b4
is: Q9UBM1
type: Species
initial concentration: NaN
name: PEMT
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:10400
initial amount: NaN
boundary condition: true

metaR r1669
is: SBO:0000185
kinetic law: MODEL1310110044#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_06ca3724_67ed_4cb6_ba17_9e6bada87826
initial concentration: NaN
name: SDHA
is: P31040
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6389
constant: false
boundary condition: true

metaR CHSTEROLtrc
type: Reaction
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
name: transport of cholesterol into the cytosol
fast: false

metaM strdnc c
type: Species
has only substance units: false
is: SBO:0000247
is: C16300
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB06547
is: http://identifiers.org/pubchem.compound/47205608
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
name: stearidonic acid C18:4, n-3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_73cc6c3e_c4cd_4b90_8fe3_383647107136
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: SLC23A1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9963

http://identifiers.org/biomodels.db/MODEL1310110044#_97e9f279_df61_4363_9f24_8d08389ff95f
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ALDH3A1
is encoded by: hsa:218
is: SBO:0000252
is: P30838
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_aa55f893_87f9_4760_91e1_048f4eab16e2
has only substance units: false
initial amount: NaN
constant: false
is: Q14432
type: Species
initial concentration: NaN
is encoded by: hsa:5139
name: PDE3A
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_83e05c7a_b8fa_45ac_bd36_c9862e256fa6
constant: false
name: SLCO1B1
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9Y6L6
initial concentration: NaN
is encoded by: hsa:10599
type: Species

metaR r1567
is: SBO:0000185
reversible: true
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false

metaR FADDPle
kinetic law: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
name: FAD diphosphatase
reactant: MODEL1310110044#
modifier: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_40d9342b_f988_4df9_a5ae_0cff7109b3d4
name: NT5C2
has only substance units: false
is: P49902
is encoded by: hsa:22978
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR ACHEe
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
reactant: MODEL1310110044#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.7
type: Reaction
name: Acetylcholinesterase
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_67899b02_2f27_488f_a2fd_66e5805e8bca
is encoded by: hsa:47
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: ACLY

metaM ibcoa m
type: Species
boundary condition: false
is: CHEBI:57338
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
initial amount: NaN
is: HMDB01243
is: SBO:0000247
constant: false
initial concentration: 1.0
name: isobutyryl-CoA(4-)

metaM cys L e
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00574
has only substance units: false
name: L-cysteine
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial amount: NaN
is: SBO:0000247
is: CHEBI:17561

metaR r2080
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110044#_e561f9ce_a574_4634_9c16_cc27029ae6f7
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:22305
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _22305_2_c

metaM cyan e
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
is: SBO:0000247
name: hydrogen cyanide
boundary condition: false
has only substance units: false
is: CHEBI:18407
initial amount: NaN
constant: false
is: HMDB02084

metaM lthstrl r
initial amount: NaN
name: 5alpha-cholest-7-en-3beta-ol
is: CHEBI:17168
initial concentration: 1.0
is: HMDB01170
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
constant: false
has only substance units: false

metaR LEUKTRB4t
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
name: leukotriene B4 transport

http://identifiers.org/biomodels.db/MODEL1310110044#_0ef3e330_52af_4b89_92be_76f254185491
has only substance units: false
constant: false
boundary condition: true
name: FLAD1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80308
is: Q8NFF5
type: Species
initial amount: NaN

metaM cytd c
is: SBO:0000247
is: HMDB00089
boundary condition: false
initial amount: NaN
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
has only substance units: false
is: CHEBI:17562
type: Species
is: C00475
initial concentration: 1.0

metaR FMNALKPle
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
name: FMNALKPle

http://identifiers.org/biomodels.db/MODEL1310110044#_f5d09676_8d58_4a7f_b7c4_86e02076121c
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: SLC3A2
is: P08195
type: Species
is encoded by: hsa:6520
is: SBO:0000252
initial amount: NaN

metaM leuktrC4 r
initial concentration: 1.0
has only substance units: false
is: HMDB01198
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57973
name: leukotriene C4(2-)

metaR r1566
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_82b7d8b6_654a_47bb_bece_24c0ae0ff2b2
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:728637
has only substance units: false
constant: false
initial concentration: NaN
name: _728637_1_c
initial amount: NaN

metaM 10fthf6glu e
has only substance units: false
boundary condition: false
type: Species
is: HMDB00972
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: CHEBI:57454
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)

http://identifiers.org/biomodels.db/MODEL1310110044#_4f9350de_2ee1_4342_8bb3_89fd2bfc50fb
constant: false
is: P54868
is encoded by: hsa:3158
has only substance units: false
initial concentration: NaN
name: HMGCS2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_c62ebeb2_88d7_414b_ae19_868ffe7f606f
type: Species
is encoded by: hsa:9057
name: SLC3A2:SLC7A6
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: Q92536
boundary condition: true
constant: false
is: SBO:0000297

metaM gtp c
boundary condition: false
is: HMDB01273
is: SBO:0000247
name: GTP
initial amount: NaN
has only substance units: false
constant: false
is: C00044
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_93ea336f_741e_4328_808b_95e03a1c37a7
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NSW9
name: SLC9A5
is encoded by: hsa:6553
constant: false

metaM ru5p D c
is: CHEBI:58121
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00618
name: D-ribulose 5-phosphate(2-)
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_19f29f62_e7c6_4a37_a028_2dbec3804a2e
has only substance units: false
name: SC5DL
is encoded by: hsa:6309
is: Q6GTM5
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR r2002
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
fast: false

metaM dkmpp c
has only substance units: false
type: Species
notes: FORMULA: C6H9O6PS CHARGE: -2
is: CHEBI:58828
initial amount: NaN
name: 2,3-diketo-5-methylthio-1-phosphopentane
constant: false
initial concentration: 1.0
boundary condition: false
is: C15650
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_8b514ea0_ec15_47d9_b4de_2566c2a0fbf0
is: SBO:0000252
initial amount: NaN
is: P27815
is encoded by: hsa:5141
type: Species
name: PDE4A
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
constant: false
is: HMDB00067
is: CHEBI:16113
initial amount: NaN
boundary condition: false
type: Species
name: cholesterol
is: SBO:0000247
has only substance units: false

metaR r0531
modifier: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reversible: true
is: SBO:0000176
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_dd9227da_1977_47e0_8722_ab630ae032f7
initial concentration: NaN
is encoded by: hsa:9107
is: Q9Y217
has only substance units: false
name: MTMR6
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM cyan c
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
constant: false
is: SBO:0000247
is: HMDB02084
name: hydrogen cyanide
is: CHEBI:18407
initial amount: NaN

metaR PRFGS
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.3
product: MODEL1310110044#
name: phosphoribosylformylglycinamidine synthase
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false

metaR NTD1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dUMP),mitochondrial
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
product: MODEL1310110044#

metaR r0202
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110044#

metaM camp c
constant: false
is: CHEBI:58165
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00058
type: Species
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
has only substance units: false
is: SBO:0000247
name: 3',5'-cyclic AMP(1-)

metaR H2Otm
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110044#
product: MODEL1310110044#
name: H2O transport, mitochondrial

metaM pmtcrn c
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00222
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: CHEBI:17490
has only substance units: false
constant: false

metaR biomass reaction
reversible: false
is described by: ECO:0000134
fast: false
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
name: Generic human biomass reaction
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR r1565
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ebb12daf_b8dd_4921_88ba_0594bf6be566
type: Species
is encoded by: hsa:4716
constant: false
boundary condition: true
initial concentration: NaN
is: A8K761
name: NDUFB10
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM h2o2 m
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB03125
is: C00027
is: CHEBI:16240
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Hydrogen peroxide
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaR r0295
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110044#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110044#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_c260507b_e7ae_45ce_9b9f_945abb41330e
initial concentration: NaN
type: Species
name: HMGCS1
initial amount: NaN
constant: false
is encoded by: hsa:3157
is: SBO:0000252
is: Q01581
has only substance units: false
boundary condition: true

metaR r2082
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR H2O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
name: hydrogen peroxide transport via diffusion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_ae0d4f73_1804_43a6_b22a_da9873be67eb
constant: false
initial amount: NaN
is encoded by: hsa:376497
is: SBO:0000252
name: SLC27A1
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_fcbcab45_5d3b_44e1_a995_685d2c93e693
has only substance units: false
constant: false
name: _AA177072_1_c
is encoded by: hsa:AA177072
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR LSTO1r
is: SBO:0000176
product: MODEL1310110044#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.21.6
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
name: Lathosterol oxidase
reactant: MODEL1310110044#
reversible: false
is described by: ECO:0000269

metaR 2AMADPTm
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
fast: false
product: MODEL1310110044#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)

metaM succ m
name: Succinate
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:30031
is: SBO:0000247
type: Species
is: C00042

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM 3oddcoa m
is: SBO:0000247
type: Species
constant: false
is: CHEBI:27868
name: 3-Oxododecanoyl-CoA
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_040d8eb8_fd53_4598_a273_90fab2e5687b
has only substance units: false
is encoded by: hsa:1836
is: SBO:0000252
is: P50443
initial amount: NaN
name: SLC26A2
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaR ORETNtn2
type: Reaction
product: MODEL1310110044#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: 13-cis-4-oxo-retinoic acid transport, Nuclear
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_064be23e_644d_4ecc_a2cc_299ee3e85dba
initial concentration: NaN
has only substance units: false
name: IDH2
boundary condition: true
constant: false
is encoded by: hsa:3418
type: Species
is: P48735
is: SBO:0000252
initial amount: NaN

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR H2Otn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110044#
name: H2O transport, nuclear
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
reversible: true

metaR r2081
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false

metaR r1564
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_8bace4e2_58a3_4c7d_b5e9_07199170ac74
is: SBO:0000252
type: Species
name: SLC25A1
boundary condition: true
is: D9HTE9
is encoded by: hsa:6576
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_d76945d6_277c_40b7_b41f_15c0c22fe547
initial concentration: NaN
boundary condition: true
is: O60658
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5151
name: PDE8A
type: Species

metaR FTCD
product: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000134
name: formimidoyltransferase cyclodeaminase
is version of: http://identifiers.org/ec-code/2.1.2.5
is: SBO:0000176
reactant: MODEL1310110044#
reversible: false
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110044#_576f323f_adb5_44a5_9160_bf3054fb94b5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is: Q6IRT1
is encoded by: hsa:128
name: ADH5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_ee6f06b4_a6f2_4827_a44f_dc1ea7d5ce4b
name: ELOVL4
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6785
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: Q9GZR5

metaM pail3p hs c
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: CHEBI:58088
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false

metaM 3mox4hoxm c
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
name: 3-Methoxy-4-hydroxymandelate
is: HMDB00291
is: SBO:0000247
is: CHEBI:27622
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_95f92877_ddde_4f24_84f1_bf321426e27b
has only substance units: false
is encoded by: hsa:9152
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q9Y345
initial amount: NaN
name: SLC6A5

metaM mev R x
is: HMDB00227
initial amount: NaN
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:36464
is: SBO:0000247
name: (R)-mevalonate
constant: false
boundary condition: false

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM sphgn c
initial concentration: 1.0
name: sphinganine(1+)
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00269

http://identifiers.org/biomodels.db/MODEL1310110044#_940b6647_8265_4052_b9b4_f2961460585c
boundary condition: true
initial concentration: NaN
is: Q03393
type: Species
has only substance units: false
is encoded by: hsa:5805
initial amount: NaN
constant: false
name: PTS
is: SBO:0000252

metaR ORNDC
product: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000269
name: Ornithine Decarboxylase
reactant: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.17
type: Reaction
modifier: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
kinetic law: MODEL1310110044#

metaR RE1836X
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110044#
name: RE1836

metaM betald c
name: betaine aldehyde
is: CHEBI:15710
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01252

metaR TYRTA
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reversible: true

metaM pe hs c
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
name: phosphatidylethanolamine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16038
has only substance units: false
type: Species

metaM hexdicoa x
has only substance units: false
type: Species
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
name: hexadecanedioylcoa
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288

metaR ACETONEt2m
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110044#

metaR r1563
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r2084
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaR THBPT4ACAMDASE
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
fast: false
reversible: false
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.96

metaR H2Otp
product: MODEL1310110044#
name: H2O transport, peroxisomal
fast: false
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185

metaR It
is described by: ECO:0000269
modifier: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
name: Iodide uniport
type: Reaction

metaR PHACCOAGLNAC
product: MODEL1310110044#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110044#
is: SBO:0000176
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110044#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM nad c
is: CHEBI:57540
is: SBO:0000247
boundary condition: false
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
constant: false
type: Species
is: HMDB00902
is: C00003
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_3b29d4ca_b0f3_41bb_81d9_519573f0e0f8
initial amount: NaN
is: P09417
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5860
name: QDPR

metaR URIt4
name: uridine transport in via sodium symport
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR PTCRTD
fast: false
reversible: true
product: MODEL1310110044#
is described by: ECO:0000134
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
type: Reaction
name: diffusion of putriscine into the endothelial cells
kinetic law: MODEL1310110044#
is: SBO:0000185

metaM HC01115 c
boundary condition: false
is: CHEBI:29025
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
name: NeuNGc

http://identifiers.org/biomodels.db/MODEL1310110044#_465fc050_ae7e_4c3c_933c_b66040403d9e
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5150
initial concentration: NaN
name: PDE7A
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_792b02e3_d1ff_41ab_9d24_d4ec64b45cb0
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2222
name: FDFT1
is: P37268
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_a35460e6_43dd_41a6_b03b_4344486b94f8
boundary condition: true
is encoded by: hsa:2180
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: P33121
name: ACSL1

metaR 3MOBte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110044#
is: SBO:0000185
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110044#
is described by: ECO:0000134
product: MODEL1310110044#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_d85352c2_4ff9_4dd3_ba0a_167496cc80e5
is: SBO:0000252
is encoded by: hsa:9167
constant: false
is: Q6FGA0
name: COX7A2L
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaR LPS3e
name: lipase, extracellular
is described by: ECO:0000000
product: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.1.3
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110044#

metaR r1562
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110044#_7c6b8aea_7383_4906_a422_bdf27a5d65ab
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: O60427
initial concentration: NaN
name: FADS1
is encoded by: hsa:3992
initial amount: NaN

metaR r2083
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
fast: false
reversible: true

metaM o2 x
initial amount: NaN
is: SBO:0000247
is: C00007
is: CHEBI:15379
has only substance units: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
boundary condition: false
name: O2
constant: false
is: HMDB01377

metaM pe hs e
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16038
name: phosphatidylethanolamine
initial concentration: 1.0

metaR EX c6crn
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

metaR r2347
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_f79d169b_b510_439b_a6e3_c0ddbb4f2e1c
has only substance units: false
initial concentration: NaN
constant: false
name: ALAS1
is: SBO:0000252
is encoded by: hsa:211
initial amount: NaN
is: Q5JAM2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_f06bc193_8454_4e1d_83f5_3fec0865163c
is: E9PB82
name: HSD17B4
constant: false
is encoded by: hsa:3295
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_9a8529ab_89ad_42d8_a2bd_728e3ac2a731
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O00217
name: NDUFS8
initial concentration: NaN
is encoded by: hsa:4728
initial amount: NaN
constant: false
type: Species

metaR TTDCAFATPc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_f3719168_f563_4f0a_82f8_e1bce757b455
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: PAICS
is encoded by: hsa:10606
is: P22234
has only substance units: false
initial amount: NaN
boundary condition: true

metaR TCYNTt
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is: SBO:0000185
kinetic law: MODEL1310110044#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reactant: MODEL1310110044#

metaR r2086
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110044#

metaR DURItn
type: Reaction
name: deoxyuridine transport in nucleus
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110044#
is: SBO:0000185

metaR r1561
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#

metaM mescon m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
type: Species
constant: false
is: SBO:0000247
name: Mesaconate
is: HMDB00749
is: CHEBI:36986

http://identifiers.org/biomodels.db/MODEL1310110044#_ee557e95_2189_4ee8_8093_a5a5818f4061
boundary condition: true
constant: false
is: Q9H0I9
name: TKTL2
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:84076
is: SBO:0000252

metaM eicostetcoa c
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
is: C16164
has only substance units: false
name: eicosatetranoyl coenzyme A

metaR DIDPtn
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reversible: true
is described by: ECO:0000000
name: dIDP nuclear transport
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR r2346
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_5f46e0b3_bd50_4df9_ba60_59b1997c0704
is encoded by: hsa:5295
type: Species
has only substance units: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
name: PIK3CA:PIK3R1
has part: P27986
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_3780fdfe_8141_4f01_bab9_48d107131498
is: SBO:0000297
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: VNN3:VNN2:VNN1

http://identifiers.org/biomodels.db/MODEL1310110044#_33387a58_f15d_42fe_a4dd_83fce00d577a
is: SBO:0000252
boundary condition: true
name: HMGCL
initial concentration: NaN
is: Q6IBC0
constant: false
is encoded by: hsa:3155
initial amount: NaN
has only substance units: false
type: Species

metaM C05957 r
name: Prostaglandin J2
is: HMDB02710
is: CHEBI:27485
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR PEt
name: phosphatidylethanolamine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
fast: false

metaR r2085
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_2735c824_e60c_43f2_8328_43ddf9835a2c
initial concentration: NaN
constant: false
is: O14986
initial amount: NaN
is encoded by: hsa:8395
name: PIP5K1B
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ffa42149_d690_4892_a800_3b30823ba1aa
constant: false
is: P78542
name: HK1
initial amount: NaN
has only substance units: false
is encoded by: hsa:3098
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_4a0b1cb7_e968_432a_9795_3382e4a43523
initial amount: NaN
is: Q53H96
is encoded by: hsa:65263
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: PYCRL

http://identifiers.org/biomodels.db/MODEL1310110044#_3e0cb604_353e_4233_972d_98fd00465510
boundary condition: true
is: Q02218
has only substance units: false
is encoded by: hsa:4967
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: OGDH

http://identifiers.org/biomodels.db/MODEL1310110044#_bd9d43bf_7689_4c65_b2d5_e528fef1c6e8
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is: E9PH29
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:10935
name: PRDX3

metaR r0074
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#

metaM malcoa c
has only substance units: false
is: C00083
is: HMDB01175
initial amount: NaN
is: CHEBI:57384
initial concentration: 1.0
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false
is: SBO:0000247
name: Malonyl-CoA
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_0f88f9c9_aa93_4c72_8ab7_a144e0a4e70a
is: SBO:0000252
initial amount: NaN
name: PPA2
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:27068

metaM hmgcoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: HMDB01375
is: CHEBI:15467
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fc383f5a_1cdf_4fce_878e_c716c6baf00b
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI440329_1_r
initial amount: NaN
is encoded by: hsa:AI440329
has only substance units: false
boundary condition: true
constant: false

metaR r1560
is: SBO:0000185
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM strdnc r
has only substance units: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: stearidonic acid C18:4, n-3
is: http://identifiers.org/pubchem.compound/47205608
type: Species
constant: false
is: HMDB06547
is: C16300

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR PUNP2
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
reactant: MODEL1310110044#
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyadenosine)
fast: false
reversible: true
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110044#_2d8684d4_795a_44a5_a27f_e4972884ba96
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _BE042354_1_m
is encoded by: hsa:BE042354
type: Species
is: SBO:0000252
constant: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaR RETNGLCt2r
is: SBO:0000185
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:14704335,PMID:2324641 NOTES:IT
type: Reaction
reversible: false
name: retinoyl glucuronide efflux (13-cis) from ER

metaR DGCHOLte
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
fast: false
name: bile acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110044#_c40dcc97_a41e_4042_9d56_4fe7ba835336
name: _AA278423_1_m
is encoded by: hsa:AA278423
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_be620867_79ce_4f4f_ba6b_4d4545b40eaa
initial concentration: NaN
name: BCKDHB
is encoded by: hsa:594
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: P21953
has only substance units: false
is: SBO:0000252

metaM HC01406 m
has only substance units: false
is: CHEBI:28264
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 3-Oxooctanoyl-CoA

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_32643cc6_d5e9_4a70_ae71_6fff4a0e583e
initial concentration: NaN
name: CHAT
is: SBO:0000252
is: Q6LEN6
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110044#_037825db_420f_42c7_9cd6_76c81d7e941b
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: O75489
constant: false
is encoded by: hsa:4722
name: NDUFS3
initial concentration: NaN
initial amount: NaN

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
name: 5-Formiminotetrahydrofolate
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB01534
type: Species
has only substance units: false
is: CHEBI:57456
is: C00664
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_0ca617ab_5876_4fea_99a8_de2296f53525
has only substance units: false
initial concentration: NaN
constant: false
name: RDH8
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NYR8
boundary condition: true
is encoded by: hsa:50700

http://identifiers.org/biomodels.db/MODEL1310110044#_64bb835c_6303_4e55_97e5_cbf34bf58668
initial concentration: NaN
type: Species
is encoded by: hsa:26266
has only substance units: false
constant: false
boundary condition: true
is: Q9UKG4
name: SLC13A4
initial amount: NaN
is: SBO:0000252

metaR PUNP1
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
type: Reaction
modifier: MODEL1310110044#
name: purine-nucleoside phosphorylase (Adenosine)
is described by: ECO:0000269
reactant: MODEL1310110044#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_5dace4e1_8e25_4635_9b23_5f2ace656c25
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: P06132
is encoded by: hsa:7389
boundary condition: true
constant: false
name: UROD

metaR LPCOXp
is version of: http://identifiers.org/ec-code/1.5.3.1
product: MODEL1310110044#
name: L-pipecolate oxidase, peroxisomal
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
reversible: false
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false

metaM HC02202 c
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57398
constant: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
has only substance units: false

metaM C02528 r
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
is: CHEBI:36234
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00518
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_8b8ea17f_9705_4057_a157_72a473d00709
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10246
constant: false
is: O00624
initial concentration: NaN
name: SLC17A2
initial amount: NaN

metaM nrpphr c
name: Norepinephrine
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
is: CHEBI:33569
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_dcab4ebf_ad37_41f2_81df_550d4cc9b079
name: OCRL
boundary condition: true
type: Species
has only substance units: false
is: Q01968
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4952

metaM glc D r
is: HMDB00122
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:4167
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
name: D-glucose

metaR PUNP4
product: MODEL1310110044#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is described by: ECO:0000269
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false

metaR PGS
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.14.99.1
name: Prostaglandin G/H synthase
fast: false
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_f3ce84b8_bf3f_42e9_8d4a_9f2e1bfa62e8
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4056
name: LTC4S
initial amount: NaN

metaR GLYSNAT5tc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR INSTt4 2
reversible: true
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
name: inositol transport via sodium symport

metaR CYSGLUexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110044#
name: L-cysteine/L-glutamine reversible exchanger
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
reversible: true
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_205d728b_3bea_406e_8a29_44901246e47f
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI620219
is: SBO:0000252
name: _AI620219_1_e

http://identifiers.org/biomodels.db/MODEL1310110044#_9401f543_afc6_4ff2_a9f0_e57a7ac7877f
name: GART
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2618
is: Q59HH3

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
constant: false
has only substance units: false
is: HMDB06321
initial amount: NaN
type: Species

metaM 3hexdtricoa m
constant: false
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: SBO:0000247
name: 3,7,10-hexadecatrienoylcoa
initial concentration: 1.0
boundary condition: false

metaR AICART
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_0f24af04_8c91_43fc_bf54_2b13fe494cff
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:219
name: ALDH1B1
is: P30837
type: Species

metaM dhbpt c
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00038
constant: false
is: SBO:0000247
name: 6,7-dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
has only substance units: false
is: CHEBI:20680

metaR BUTt2r
is: SBO:0000185
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#
name: Butyrate transport via proton symport, reversible
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000269
type: Reaction

metaR ILEtec
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110044#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
fast: false
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_ca891f56_de10_4c48_8f12_058716265066
name: ENTPD2
is: Q5SPY7
is encoded by: hsa:954
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR PUNP3
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110044#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Guanosine)
modifier: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM CE2433 m
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
constant: false
is: SBO:0000247
is: CHEBI:57795
type: Species
initial amount: NaN
initial concentration: 1.0

metaM hexdiac c
boundary condition: false
initial concentration: 1.0
is: HMDB00672
has only substance units: false
notes: FORMULA: C16H28O4 CHARGE: -2
is: C08260
type: Species
is: SBO:0000247
name: hexadecanediocacid
constant: false
initial amount: NaN

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR AICARte
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110044#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
is described by: ECO:0000134
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_79e4813d_84fd_4533_ba13_b12817b64ee2
initial concentration: NaN
is encoded by: hsa:55361
type: Species
name: PI4K2A
is: Q9BTU6
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_659300ad_a94a_431e_af4a_4147902cfa78
constant: false
initial concentration: NaN
is encoded by: hsa:4047
initial amount: NaN
is: E9PEI9
type: Species
name: LSS
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR ACHtn
product: MODEL1310110044#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
name: Acetylcholin transport, nuclear trhough pores
is: SBO:0000185
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110044#_8b78f2a6_f137_47a9_9ee6_a0cdf8066fc5
type: Species
is encoded by: hsa:AI971036
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI971036_1_m
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7f354bf6_67ad_4cbc_835a_4338f9619f80
is encoded by: hsa:112
has only substance units: false
name: ADCY6
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM coa c
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
name: Coenzyme A
is: HMDB01423
constant: false
is: CHEBI:3312
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00010
type: Species

metaR TKT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase

metaM co2 x
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16526
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: carbon dioxide
is: HMDB01967
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR PUNP6
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110044#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyinosine)
modifier: MODEL1310110044#
fast: false

metaM grdp x
initial concentration: 1.0
initial amount: NaN
is: HMDB01285
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
name: geranyl diphosphate(3-)
type: Species
constant: false
is: CHEBI:58057

metaM CE2424 m
is: CHEBI:28387
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
boundary condition: false

metaM ei11ecoa x
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
name: 11-eicosenoylcoa
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial amount: NaN

metaM 13 cis retnglc r
has only substance units: false
initial concentration: 1.0
is: CHEBI:28870
constant: false
boundary condition: false
name: 13-cis-retinoyl glucuronide
is: SBO:0000247
type: Species
notes: FORMULA: C26H35O8 CHARGE: -1 INCHI: InChI=1S/C26H36O8/c1-15(11-12-18-17(3)10-7-13-26(18,4)5)8-6-9-16(2)14-19(27)33-25-22(30)20(28)21(29)23(34-25)24(31)32/h6,8-9,11-12,14,20-23,25,28-30H,7,10,13H2,1-5H3,(H,31,32)/b9-6+,12-11+,15-8+,16-14+/t20-,21-,22+,23-,25+/m0/s1
initial amount: NaN
is: HMDB03141

http://identifiers.org/biomodels.db/MODEL1310110044#_dc32e87d_f067_4ab4_aecb_d649a3d0714c
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_68ea3286_0515_4f1b_88d4_0c2739693f27
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: _AI091231_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI091231

metaM g6p r
is: CHEBI:61548
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01401
boundary condition: false
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: SBO:0000247
name: D-Glucose 6-phosphate
initial concentration: 1.0
is: C00092

metaR TKT1
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
kinetic law: MODEL1310110044#
is described by: ECO:0000000
modifier: MODEL1310110044#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true

metaM 3octdectecoa m
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
type: Species
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_6cf50c0e_0afc_499b_b069_ced3850ec2bb
is: Q96C36
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:29920
name: PYCR2
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_039019c1_d144_4488_ab58_e5435ee79d05
is encoded by: hsa:51095
initial amount: NaN
constant: false
is: SBO:0000252
is: Q96Q11
name: TRNT1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaR CGLYt3 2
modifier: MODEL1310110044#
fast: false
reversible: false
kinetic law: MODEL1310110044#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
product: MODEL1310110044#
is: SBO:0000185
name: Cys-Gly transport in via proton symport
reactant: MODEL1310110044#
type: Reaction

metaM amet r
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15414
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
boundary condition: false
name: S-adenosyl-L-methionine
constant: false
is: HMDB01185

metaM dtdp e
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
type: Species
is: HMDB01274
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_f79aa81d_2420_4c32_be2d_7268ac944c4f
is: A6NFM2
name: PYCR1
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5831
initial concentration: NaN
has only substance units: false

metaR EX c4dc
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaR TYROXDAc
reversible: false
is: SBO:0000176
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
is version of: http://identifiers.org/ec-code/1.4.3.4
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false

metaR r1559
product: MODEL1310110044#
reversible: true
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_242baeca_1730_4159_b4d4_241df2ecf42e
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51102
is: Q9BV79
type: Species
name: MECR
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_e2d4b087_2489_4b71_97c6_081ff418f470
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: _AA278423_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA278423
constant: false

metaM succ x
boundary condition: false
is: SBO:0000247
is: HMDB00254
is: CHEBI:30031
constant: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
name: Succinate
is: C00042
has only substance units: false
initial amount: NaN

metaR H2Otg
fast: false
reversible: true
reactant: MODEL1310110044#
name: H2O transport, Golgi apparatus
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR SUCOASm
kinetic law: MODEL1310110044#
fast: false
reversible: true
product: MODEL1310110044#
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_c8f53b80_9c05_495c_aea1_25878c0d8c4f
is: Q5JZF5
boundary condition: true
name: ALAS2
type: Species
initial concentration: NaN
is encoded by: hsa:212
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_1a198186_a525_47fd_955c_5e9fe1ef0bca
constant: false
boundary condition: true
name: COX6A1
initial amount: NaN
is encoded by: hsa:1337
is: SBO:0000252
has only substance units: false
is: P12074
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_544ae9d9_3272_4e86_80f5_8ff4694688cd
type: Species
name: PLCG1
is encoded by: hsa:5335
is: SBO:0000252
is: P19174
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR PYRt2m
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
name: pyruvate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR r1556
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#

metaM coa e
is: CHEBI:57287
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: Coenzyme A
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
is: C00010
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110044#_512b7118_fb4b_4191_863f_79da1d1c45f7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:R51273
name: _R51273_1_c
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_937e612d_2b0c_46fe_95bb_f230930c0f63
name: PLCE1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:51196
has only substance units: false
is: Q9P212
constant: false

metaR r0752
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
modifier: MODEL1310110044#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR TXASr
name: Thromboxane-A synthase
modifier: MODEL1310110044#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.5
reversible: false
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000134

metaR METtec
modifier: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110044#
is: SBO:0000185
name: L-methionine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_06e08ad3_c7d4_4b5b_9320_95a47be01881
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: _U37519_1_m
boundary condition: true
has only substance units: false
is encoded by: hsa:U37519

metaR r0210
is: SBO:0000176
product: MODEL1310110044#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
type: Reaction

metaR PUNP7
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
name: purine-nucleoside phosphorylase (Xanthosine)
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reversible: true
type: Reaction

metaM dtdp c
is: SBO:0000247
name: dTDP
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
type: Species
is: HMDB01274
is: C00363
initial concentration: 1.0
boundary condition: false

metaR r2090
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM CE2435 m
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false

metaR r1557
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#

metaM dd2coa x
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial concentration: 1.0
is: CHEBI:57330
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: trans-Dodec-2-enoyl-CoA
has only substance units: false
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110044#_818664b4_fd96_4637_8c3a_2ba1fe65d10d
is encoded by: hsa:275
initial amount: NaN
has part: P09622
has part: P23378
has only substance units: false
name: DLD:GCSH:GLDC:AMT
is: SBO:0000297
is encoded by: hsa:2731
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:2653
type: Species
has part: P23434
is encoded by: hsa:1738
has part: P48728

metaM oaa x
boundary condition: false
initial amount: NaN
is: CHEBI:16452
is: HMDB00223
name: Oxaloacetate
constant: false
type: Species
has only substance units: false
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
initial concentration: 1.0
is: SBO:0000247

metaM nrpphr e
type: Species
is: HMDB00216
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:33569
is: SBO:0000247
has only substance units: false

metaR r0753
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
product: MODEL1310110044#

metaM HC02202 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
is: CHEBI:57398
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: prostaglandin A1(1-)

metaR ETOHt
fast: false
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: ethanol reversible transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_74ce8390_fd1a_43c1_ad22_7764807b3b73
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:56848
name: SPHK2
is: Q9NRA0
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR r0641
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
product: MODEL1310110044#
reversible: true

metaM 2mp2coa m
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01011
is: CHEBI:27754
initial amount: NaN
constant: false

metaR HISCAT1
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR r1117
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
name: Facilitated diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110044#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_1a93a431_fc0c_48b3_a5a1_5bbd71acfd6f
initial concentration: NaN
name: NDUFC2
type: Species
is encoded by: hsa:4718
is: Q549M5
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r1671
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
modifier: MODEL1310110044#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR MCITS
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: 2-methylcitrate synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
fast: false

metaR FRUt4
modifier: MODEL1310110044#
is described by: ECO:0000269
fast: false
product: MODEL1310110044#
name: D-fructose transport via sodium cotransport
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
type: Reaction

metaR r0853
reactant: MODEL1310110044#
product: MODEL1310110044#
name: Facilitated diffusion
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is described by: ECO:0000000

metaR r2420
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_be5d1ca0_575e_4c1a_b02f_50b217247f1d
initial amount: NaN
is encoded by: hsa:158
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ADSL
constant: false
type: Species
initial concentration: NaN
is: P30566

http://identifiers.org/biomodels.db/MODEL1310110044#_cfacba38_1a7a_4ac8_b8e9_2a4b947de597
name: UCP3
boundary condition: true
has only substance units: false
is encoded by: hsa:7352
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: P55916

http://identifiers.org/biomodels.db/MODEL1310110044#_24dc0d10_390a_42c1_a18e_69aa7cb293fa
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1103
has only substance units: false
is: D3DX95
initial amount: NaN
initial concentration: NaN
type: Species
name: CHAT

metaM hmgcoa c
is: CHEBI:15467
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
is: HMDB01375
type: Species

metaR SERtN1
is described by: ECO:0000269
fast: false
reactant: MODEL1310110044#
name: Serine transport (Na, H coupled)
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: true

metaR ARGLYSex
modifier: MODEL1310110044#
product: MODEL1310110044#
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110044#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110044#
name: Arginine/Lysine exchanger (Arg in)

http://identifiers.org/biomodels.db/MODEL1310110044#_4417ae19_03c3_488b_a58b_5757eacdc16a
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: P16152
is: SBO:0000252
name: CBR1
has only substance units: false
is encoded by: hsa:873
boundary condition: true

metaR r0642
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110044#_83b73c95_19f8_471d_b42e_5515997cf0d6
is: P21399
is: SBO:0000252
name: ACO1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:48
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_1e7284da_be37_48cd_a431_010c0882a33a
has only substance units: false
boundary condition: true
initial concentration: NaN
name: MLYCD
is: O95822
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:23417

metaR DESAT20 1
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110044#
is: SBO:0000176
reversible: false

metaR r1116
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110044#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_e7430f5d_dde1_444a_8035_392ac83743ac
boundary condition: true
is: SBO:0000252
name: IK
initial concentration: NaN
constant: false
is encoded by: hsa:3550
has only substance units: false
initial amount: NaN
type: Species
is: Q13123

metaR L LACt2r
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
name: L-lactate reversible transport via proton symport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2cc37937_5cb9_482e_8615_1fb3d08654b5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA081045
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: _AA081045_1_c

metaR CYTK8n
is: SBO:0000176
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: cytidylate kinase (CMP,dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR r0321
modifier: MODEL1310110044#
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.2
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:

metaM nad n
constant: false
is: HMDB00902
type: Species
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
initial amount: NaN
name: NAD(1-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR RE1532M
is described by: ECO:0000000
modifier: MODEL1310110044#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110044#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1532

metaM CE0693 m
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
constant: false
has only substance units: false
is: CHEBI:28387
is: SBO:0000247
is: HMDB11123
initial concentration: 1.0
name: 3-oxolaur-6-cis-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110044#_80b245fa_1bd6_4606_a204_ccd481f86529
has only substance units: false
type: Species
is: Q3I5F7
is encoded by: hsa:641372
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: ACOT6

metaM HC02175 e
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
boundary condition: false
is: CHEBI:27689
is: SBO:0000247
has only substance units: false
name: caprate
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_78821833_0cac_4ae3_9502_fa6fdf791586
is: SBO:0000252
initial amount: NaN
is: B4DK61
has only substance units: false
initial concentration: NaN
constant: false
name: ACOX1
boundary condition: true
is encoded by: hsa:51
type: Species

metaM bilirub r
constant: false
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: CHEBI:57977
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: bilirubin(2-)
is: HMDB00054
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7869bf10_1e9a_4dc3_844b_2382e08b8636
has only substance units: false
is encoded by: hsa:3628
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: INPP1
boundary condition: true
is: P49441

metaR PGK
type: Reaction
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.2.3
is described by: ECO:0000134
reactant: MODEL1310110044#
name: phosphoglycerate kinase
fast: false
modifier: MODEL1310110044#

metaR H2O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion
is: SBO:0000185
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
fast: false

metaR SPHS1Pte
product: MODEL1310110044#
fast: false
reversible: true
name: sphingosine-1-phosphate transport
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
type: Reaction

metaR PNTOte
fast: false
is described by: ECO:0000134
type: Reaction
name: Transport of (R)-Pantothenate
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true

metaR ASCBt4
is described by: ECO:0000269
kinetic law: MODEL1310110044#
fast: false
reversible: true
name: L-ascorbate transport via proton symport
modifier: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110044#

metaR r2360
kinetic law: MODEL1310110044#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#

metaR RE1520M
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1520
reactant: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000

metaM ura e
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
name: uracil
is: HMDB00300
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17568
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_477374fa_2633_497d_8fdc_748d6ddfba41
initial amount: NaN
initial concentration: NaN
name: NDUFV3
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4731
is: P56181
boundary condition: true

metaM nad m
initial amount: NaN
is: C00003
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00902
type: Species

metaR r0644
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

MODEL1310110044#
species: metaM occoa m
species: metaM 3hmp m
species: metaM 3pg m
species: metaM dcsptn1coa m
species: metaM ala B c
species: metaM dhlam m
species: metaM 5aizc c
species: metaM nadph c
species: metaM cdp n
species: metaM acac c
species: metaM pnto R c
species: metaM datp m
species: metaM 1pyr5c c
species: metaM h n
species: metaM lys L e
species: metaM 2decdicoa m
species: metaM ptrc e
species: metaM 4mop m
species: metaM gthrd c
species: metaM CE5119 m
species: metaM eicostetcoa c
species: metaM chsterol e
species: metaM CE0693 m
species: metaM ac c
species: metaM mal L e
species: metaM amet r
species: metaM HC01610 e
species: metaM dgchol e
species: metaM imp c
species: metaM C02528 e
species: metaM hexdicoa x
species: metaM 2docohexecoa m
species: metaM mi4p D c
species: metaM andrstrn r
species: metaM acac x
is: SBO:0000297
species: metaM paps c
species: metaM 2hb e
species: metaM fad e
species: metaM pan4p c
species: metaM didp n
type: ModifierSpeciesReference
species: metaM ctp n
species: metaM fol e
species: metaM cyan c
species: metaM ura c
species: metaM ttdca c
species: metaM utp c
stoichiometry: 0.002914
species: metaM gam e
species: metaM gua e
species: metaM asp D e
species: metaM 4hphac e
species: metaM udpg r
species: metaM hexde7coa x
species: metaM his L c
species: metaM dgtp e
species: metaM pail345p hs c
species: metaM dhap c
species: metaM ser D e
species: metaM taur e
species: metaM CE2434 m
species: metaM itp e
species: metaM arg L c
stoichiometry: 0.5
species: metaM 3mop e
species: metaM didp c
species: metaM na1 r
species: metaM octe5coa m
value: 0.0
species: metaM nadp x
species: metaM ca2 c
species: metaM ser L e
species: metaM so4 e
stoichiometry: 0.275194
species: metaM dgsn c
species: metaM CE4794 m
species: metaM thr L e
species: metaM dsmsterol r
species: metaM aicar c

metaM ura c
initial amount: NaN
is: HMDB00300
type: Species
boundary condition: false
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
is: CHEBI:17568
constant: false
is: C00106
initial concentration: 1.0
is: SBO:0000247

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
fast: false

metaR r1670
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Y+LAT2 Utilized transport
fast: false

metaM 5dpmev x
is: HMDB01090
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15899
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
has only substance units: false
name: (R)-5-Diphosphomevalonate
initial amount: NaN
constant: false
boundary condition: false

metaR DOPAtu
name: Dopamine uniport
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
reactant: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#

metaR r1050
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is described by: ECO:0000000
name: Vesicular transport
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d435cefc_e14d_4282_9311_1c19378094f9
boundary condition: true
has only substance units: false
name: PIK3C2G
is encoded by: hsa:5288
initial concentration: NaN
constant: false
type: Species
is: O75747
is: SBO:0000252
initial amount: NaN

metaM dcsptn1crn m
is: HMDB06321
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
initial concentration: 1.0

metaR PGI
modifier: MODEL1310110044#
type: Reaction
name: glucose-6-phosphate isomerase
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/5.3.1.9
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_28fa696e_571b_47e4_9c20_bc9a64923d3d
is: SBO:0000252
initial concentration: NaN
name: SLC2A12
has only substance units: false
is: Q8TD20
is encoded by: hsa:154091
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaR NRPPHRtu
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
fast: false
name: Norepinephrine uniport
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaM HC02175 c
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:27689
initial concentration: 1.0
name: caprate

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR DNDPt33m
is: SBO:0000185
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
product: MODEL1310110044#
fast: false
name: dGDP transport via dUDP antiport
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaM succoa x
boundary condition: false
constant: false
has only substance units: false
type: Species
is: HMDB01022
initial concentration: 1.0
initial amount: NaN
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247

metaR r1051
is: SBO:0000185
name: Vesicular transport
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true

metaR 3MOX4HOXPGALDOX
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000304
reversible: false

metaM nicrnt c
name: Nicotinate D-ribonucleotide
initial amount: NaN
is: HMDB01132
is: CHEBI:57502
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: SBO:0000247
is: C01185
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_2b91af77_90c3_4af0_8ee4_876d4ef3e1e0
boundary condition: true
is: SBO:0000252
is encoded by: hsa:221
initial amount: NaN
type: Species
name: ALDH3B1
constant: false
is: P43353
has only substance units: false
initial concentration: NaN

metaR SRTNtu
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000269
name: Serotonin uniport
fast: false
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaM strdnc l
is: SBO:0000247
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial concentration: 1.0
initial amount: NaN
is: C16300
is: HMDB06547
is: http://identifiers.org/pubchem.compound/47205608
type: Species
has only substance units: false
name: stearidonic acid C18:4, n-3
boundary condition: false
constant: false

metaR RE3269C
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is: SBO:0000176
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.48
product: MODEL1310110044#
name: RE3269
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#

metaM 34dhpha c
initial amount: NaN
is: CHEBI:17612
boundary condition: false
is: HMDB01336
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
type: Species
initial concentration: 1.0
name: (3,4-dihydroxyphenyl)acetate

metaM anth c
type: Species
boundary condition: false
initial concentration: 1.0
name: anthranilate
is: SBO:0000247
is: HMDB01123
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108

metaM cdpdag hs c
is: SBO:0000247
is: CHEBI:58332
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
name: CDP-diacylglycerol(2-)
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fba09ea3_9db2_4f24_8721_09de1306d484
name: PIP4K2C
boundary condition: true
constant: false
is encoded by: hsa:79837
initial amount: NaN
type: Species
is: B3KQV3
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM HC02210 c
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-d3
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: CHEBI:34939

metaR PYRt2r
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
modifier: MODEL1310110044#
is described by: ECO:0000269
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
fast: false
name: pyruvate reversible transport via proton symport
reactant: MODEL1310110044#

metaR CDS
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
reversible: false
type: Reaction
reactant: MODEL1310110044#
name: phosphatidate cytidylyltransferase
product: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM nad r
has only substance units: false
name: NAD(1-)
constant: false
type: Species
is: HMDB00902
is: CHEBI:57540
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR GLCt4
name: glucose transport via sodium symport
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reactant: MODEL1310110044#
reversible: true

metaM dhlam m
is: CHEBI:17694
type: Species
initial concentration: 1.0
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
constant: false
boundary condition: false
is: HMDB00985
name: dihydrolipoamide
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_30ab2604_f360_44d3_96d5_c46a95c21351
initial amount: NaN
is encoded by: hsa:4598
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: B2RDU6
boundary condition: true
name: MVK
constant: false

metaR AATAi
reactant: MODEL1310110044#
name: 2-aminoadipate transaminase, irreversible
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
type: Reaction

metaR DESAT20 2
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
is: SBO:0000176
product: MODEL1310110044#
reversible: false
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_7612e242_8396_41a7_a4f3_c7b82f08c496
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110044#_a9252dd8_fce5_4b7e_8113_57bcd6ae4b8f
name: VNN3
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55350
boundary condition: true
constant: false

metaM mmcoa S m
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
constant: false
is: SBO:0000247
name: (S)-methylmalonyl-CoA(5-)
is: HMDB02310
boundary condition: false
is: CHEBI:57327
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r1260
reversible: false
is described by: ECO:0000000
name: EC:6.2.1.3
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR CMPSASn
name: CMP sialic acid synthase, nuclear
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
modifier: MODEL1310110044#

metaM HC02210 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:34939
name: prostaglandin-d3

http://identifiers.org/biomodels.db/MODEL1310110044#_bd82e3a4_4e80_41bb_bf2c_a6e81749d9d5
constant: false
name: GLRX2
is encoded by: hsa:51022
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_3a728b00_4dc2_4595_b0d2_ba7cf37e25e4
is: Q7LBE3
constant: false
is: SBO:0000252
name: SLC26A9
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:115019
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_7958214d_0520_41d3_989f_419e1d072403
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: O00746
name: NME4
initial concentration: NaN
is encoded by: hsa:4833
has only substance units: false

metaM anth e
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01123
initial concentration: 1.0
constant: false
name: anthranilate
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: CHEBI:16567

http://identifiers.org/biomodels.db/MODEL1310110044#_26b44f88_5d68_471f_8fe4_ad78b02c91f5
initial amount: NaN
constant: false
is encoded by: hsa:55811
boundary condition: true
has only substance units: false
is: SBO:0000252
is: F5GWS5
initial concentration: NaN
name: ADCY10
type: Species

metaR MCCCrm
is: SBO:0000176
name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.4.1.4
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
type: Reaction

metaR r0186
reactant: MODEL1310110044#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
product: MODEL1310110044#
reversible: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
kinetic law: MODEL1310110044#

metaR r2140
product: MODEL1310110044#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_495ee3b0_d208_49af_97ea_63514b566f2a
initial amount: NaN
is: SBO:0000252
is: B3KMA6
type: Species
is encoded by: hsa:2181
initial concentration: NaN
boundary condition: true
name: ACSL3
constant: false
has only substance units: false

metaR r0660
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
product: MODEL1310110044#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_f2314d96_d841_4583_a3ac_ea09fe0dd38c
has only substance units: false
name: _D29675_1_e
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:D29675
is: SBO:0000252
initial concentration: NaN

metaR FAOXC16DCr
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR r2355
kinetic law: MODEL1310110044#
reversible: true
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7b5bb45f_3613_4b53_a9e0_c714476fbf22
is: SBO:0000252
initial concentration: NaN
name: PLCH2
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:9651
boundary condition: true
is: O75038
type: Species

metaR r2202
reversible: true
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110044#

metaM sphs1p c
initial amount: NaN
is: HMDB00277
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)

metaR DKMPPD
reversible: false
type: Reaction
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)

metaR r1464
name: Active transport
fast: false
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110044#

metaM HC02207 c
name: prostaglandin-c2
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27555
is: SBO:0000247
boundary condition: false

metaM udp c
has only substance units: false
is: CHEBI:58223
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: UDP
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
constant: false
is: SBO:0000247
is: C00015

http://identifiers.org/biomodels.db/MODEL1310110044#_91008c3b_01d3_450a_bae2_d6e63902e8d7
initial amount: NaN
is encoded by: hsa:125206
has only substance units: false
boundary condition: true
name: SLC5A10
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: A0PJK1

http://identifiers.org/biomodels.db/MODEL1310110044#_54cb40e5_2a80_4b30_a244_e9457235431f
name: ALDH2
constant: false
type: Species
initial amount: NaN
is: P05091
is encoded by: hsa:217
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_36bcc27e_b75b_40fe_8011_52f6bea395f1
initial concentration: NaN
name: HSD17B4
boundary condition: true
constant: false
has only substance units: false
is: E9PB82
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3295
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_26f4ab48_4c3f_4ef1_9265_95eef03f344e
type: Species
initial concentration: NaN
name: LDHC
constant: false
is encoded by: hsa:3948
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P07864

http://identifiers.org/biomodels.db/MODEL1310110044#_b5017128_c5a8_43dc_97bd_2d7297dbdc90
is: P30084
constant: false
initial amount: NaN
is encoded by: hsa:1892
has only substance units: false
name: ECHS1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_fc3bf680_db22_41ef_b216_8ec05db4873b
is: SBO:0000252
is encoded by: hsa:5143
is: Q7KYS4
constant: false
name: PDE4C
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_62a5dd6a_d7df_45c5_860b_d83b26b62b86
type: Species
name: ACOX1
is encoded by: hsa:51
is: SBO:0000252
is: B4DK61
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r1924
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2141
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

metaR r2354
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
fast: false

metaR r2201
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110044#
type: Reaction

metaR PAIL HStn
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaM CE5788 e
type: Species
name: kinetensin 1-7
constant: false
is: CHEBI:27485
initial concentration: 1.0
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
boundary condition: false
is: SBO:0000247
is: HMDB02710
has only substance units: false
initial amount: NaN

metaR r2406
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reversible: false

metaM thcholstoic m
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
constant: false
is: HMDB03873
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
has only substance units: false

metaR r0437
is described by: ECO:0000000
product: MODEL1310110044#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction

metaR UMPK6n
reversible: true
fast: false
product: MODEL1310110044#
is described by: ECO:0000269
name: UMP kinase (dCTP),nuclear
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM oaa m
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223
name: Oxaloacetate
boundary condition: false
is: CHEBI:16452
is: SBO:0000247
is: C00036
has only substance units: false
constant: false

metaM itaccoa m
type: Species
has only substance units: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
constant: false
initial concentration: 1.0
is: CHEBI:57381
is: HMDB03377
is: SBO:0000247
initial amount: NaN
name: itaconyl-CoA(5-)
boundary condition: false

metaR C226CRNt
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: C226 transport into the mitochondria
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000

metaR GLYt7 311 r
type: Reaction
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110044#
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
reversible: true

metaM sphs1p e
is: CHEBI:60119
boundary condition: false
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
type: Species
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
is: HMDB00277
initial amount: NaN
constant: false

metaR CHOLATEt
reversible: true
is described by: ECO:0000269
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110044#
name: cholate transport via bicarbonate countertransport
is: SBO:0000185
kinetic law: MODEL1310110044#
fast: false

metaR r2142
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#

metaR PSDm hs
modifier: MODEL1310110044#
product: MODEL1310110044#
name: Phosphatidylserine decarboxylase
kinetic law: MODEL1310110044#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.65
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ

metaR r1571
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR r2379
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reversible: true
product: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_9046fa8c_7632_4ea9_9cf9_281e10ab4d03
is: P46926
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: GNPDA1
is encoded by: hsa:10007
initial amount: NaN
type: Species

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_84852cd3_6481_4e9a_aedd_61935b6dd42f
boundary condition: true
is: Q8N0X4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: CLYBL
is encoded by: hsa:171425
type: Species
constant: false
has only substance units: false

metaR r2357
fast: false
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185

metaR DM ethamp r
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR LEUKTRD4tr
name: leukotriene intracellular transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110044#
fast: false

metaR r2356
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport

metaR NDPK1m
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
reversible: true
fast: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR PPA
reversible: false
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
kinetic law: MODEL1310110044#
name: inorganic diphosphatase
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_1fb96672_924e_4d10_895d_7ffe8e9a63b9
is: SBO:0000252
name: CA9
is encoded by: hsa:768
is: Q16790
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM coa x
is: C00010
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
name: Coenzyme A
initial concentration: 1.0
is: HMDB01423
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57287

metaR r1570
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110044#
fast: false

metaR r2378
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
fast: false

metaM c226coa m
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: cervonyl coenzyme A
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1

metaR r0193
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176

metaR RE1709N
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE1709
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
fast: false
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_01fb2c46_b86f_4ec6_9a23_b33c13e4ecba
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:50
is: Q99798
constant: false
boundary condition: true
is: SBO:0000252
name: ACO2

metaR GGH 5DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (5DHF), extracellular
type: Reaction
product: MODEL1310110044#
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR FTHFL
kinetic law: MODEL1310110044#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
reactant: MODEL1310110044#
reversible: true
name: Formate-tetrahydrofolate ligase
product: MODEL1310110044#
is described by: ECO:0000134
modifier: MODEL1310110044#

metaM mi145p c
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01498
is: CHEBI:203600
type: Species
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
boundary condition: false

metaR PHYCBOXL
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
is described by: ECO:0000212
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: L-Phenylalanine carboxy-lyase
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_701451d2_1294_4485_a58f_b24d56b05bf5
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: _AI285872_1_c
is encoded by: hsa:AI285872
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM lnlc e
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00673
is: SBO:0000247
is: CHEBI:30245
name: linoleate
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
constant: false

metaR r2377
kinetic law: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM trp L e
boundary condition: false
is: HMDB00929
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16828
initial concentration: 1.0
initial amount: NaN
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species

metaR NRPPHRt4 2 r
name: Norepinephrine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
is: SBO:0000185
type: Reaction

metaR NDPK1n
type: Reaction
reactant: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000134
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaM ascb L c
name: L-ascorbate
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
is: CHEBI:38290
initial concentration: 1.0
initial amount: NaN
is: HMDB00044
boundary condition: false

metaR RE1796M
name: RE1796
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_85ee7141_447d_4b6f_a9e3_9115f4baa57a
is encoded by: hsa:53354
name: PANK1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q8TE04
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR r0434
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaR C4DCe
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_625046d7_2a31_42db_a047_a90e396e1f85
constant: false
is encoded by: hsa:6549
has only substance units: false
is: Q9UBY0
is: SBO:0000252
type: Species
initial amount: NaN
name: SLC9A2
boundary condition: true
initial concentration: NaN

metaR TREHe
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
name: alpha,alpha-trehalase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
modifier: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.28

metaR GTHRDtr
product: MODEL1310110044#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
reactant: MODEL1310110044#
name: glutathione transport via diffusion
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a74add7a_179e_40a9_a31e_61d48c98b9ec
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:18
is: P80404
boundary condition: true
name: ABAT
initial concentration: NaN
constant: false
has only substance units: false

metaM 2mop m
has only substance units: false
is: CHEBI:57700
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
constant: false
is: HMDB01172
type: Species

metaM mercppyr c
boundary condition: false
name: 3-mercaptopyruvate
constant: false
is: CHEBI:57678
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01368
has only substance units: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957

metaR ADK3
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
modifier: MODEL1310110044#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adentylate kinase (GTP)
kinetic law: MODEL1310110044#

metaR r2376
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#
fast: false

metaM retinal cis 13 r
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:45487
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
initial concentration: 1.0
name: 13-cis-retinal
type: Species
is: SBO:0000247
initial amount: NaN

metaM g6p c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61548
boundary condition: false
is: SBO:0000247
type: Species
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
constant: false
is: HMDB01401
has only substance units: false

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM C02528 c
is: CHEBI:36234
initial concentration: 1.0
name: chenodeoxycholate
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR 34DHPHEt
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
is described by: ECO:0000269
name: 3,4-Dihydroxy-L-phenylalanine transport
type: Reaction
product: MODEL1310110044#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaR MDRPD
product: MODEL1310110044#
is: SBO:0000176
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
reversible: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- Based on reaction given for B. subtilis (Sekowska A and A. Danchin paper(2002) )
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_08b2cb04_1f63_416f_aa86_cbafebd8c742
is: SBO:0000252
name: _AI191472_1_c
type: Species
boundary condition: true
is encoded by: hsa:AI191472
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR CITt4 4
is described by: ECO:0000006
type: Reaction
fast: false
name: citrate transport via sodium symport
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR GLYCtm
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: glycerol transport
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110044#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_506491ce_e4c4_4189_a0b6_916c8b34eaf2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:121278
constant: false
initial amount: NaN
initial concentration: NaN
is: Q8IWU9
name: TPH2
type: Species
has only substance units: false

metaR LEUt4
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
modifier: MODEL1310110044#
product: MODEL1310110044#
name: L-leucine transport in via sodium symport
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_64dadeb3_442e_43f4_8709_bda0e7776fb1
is: SBO:0000252
initial concentration: NaN
name: CPT1C
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: Q8TCG5
has only substance units: false
is encoded by: hsa:126129

metaM lnlc c
constant: false
type: Species
boundary condition: false
name: linoleate
initial amount: NaN
is: CHEBI:30245
is: HMDB00673
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false

metaR r2375
type: Reaction
is: SBO:0000185
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaM fad x
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
has only substance units: false
is: HMDB01248

http://identifiers.org/biomodels.db/MODEL1310110044#_b18b0ece_b483_4cda_a669_5a507602c5f5
initial amount: NaN
initial concentration: NaN
is: O15121
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8560
type: Species
has only substance units: false
constant: false
name: DEGS1

metaR ILEt4
reversible: false
fast: false
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110044#
name: L-isoleucine transport in via sodium symport
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_68d7be52_d289_4246_9e44_9a5e0d6f5e01
is: O75521
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: ECI2
has only substance units: false
type: Species
is encoded by: hsa:10455
initial concentration: NaN

metaR NTD2e
fast: false
reactant: MODEL1310110044#
name: 5'-nucleotidase (UMP), extracellular
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000134
modifier: MODEL1310110044#

metaR MCLACCYSR
kinetic law: MODEL1310110044#
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is described by: ECO:0000000
name: 3-mercaptolactate:cysteine reductase
type: Reaction
product: MODEL1310110044#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_14b11391_5780_4f02_83a7_1ecc237d3be8
is: SBO:0000252
type: Species
initial concentration: NaN
is: P47895
is encoded by: hsa:220
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: ALDH1A3

metaM ascb L e
has only substance units: false
name: L-ascorbate
type: Species
boundary condition: false
is: CHEBI:38290
initial amount: NaN
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM HC02207 e
type: Species
has only substance units: false
is: CHEBI:27555
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaR r2353
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
type: Reaction

metaR IZPN
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110044#
name: Imidazolonepropionase
reversible: false
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_ac5c3bc9_2f23_4c41_824d_12ec84d7beaa
is: Q5JRA6
name: MIA3
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:375056
has only substance units: false
initial concentration: NaN

metaM trp L c
boundary condition: false
is: HMDB00929
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
is: SBO:0000247
name: L-tryptophan
type: Species
initial amount: NaN

metaR TDCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#

metaR LDH D
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
modifier: MODEL1310110044#
name: D-lactate dehydrogenase
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.2.4
kinetic law: MODEL1310110044#
reversible: true
fast: false
product: MODEL1310110044#

metaM pail5p hs c
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_85bf6e47_6cab_4cef_8151_6861783fd4e6
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55902
constant: false
name: ACSS2
is: Q96FY7

http://identifiers.org/biomodels.db/MODEL1310110044#_72235b16_6a13_4251_8d15_b6c3b1a141d7
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR GAPD
modifier: MODEL1310110044#
reactant: MODEL1310110044#
name: glyceraldehyde-3-phosphate dehydrogenase
product: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
type: Reaction

metaR ADK1
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
type: Reaction
fast: false
name: adenylate kinase
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110044#
is described by: ECO:0000269
reactant: MODEL1310110044#

metaR IDPtn
is: SBO:0000185
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
name: IDP nuclear transport

metaR CTPtn
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: CTP diffusion in nucleus
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR r2374
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
type: Reaction

metaM C02528 e
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
has only substance units: false
is: HMDB00518
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: chenodeoxycholate
is: CHEBI:36234

metaR C160CPT2
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000269
name: C160 transport into the mitochondria
product: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110044#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR r2079
product: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR r2352
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction

metaR PETOHMr hs
type: Reaction
name: phosphatidylethanolamine N-methyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
reversible: false
modifier: MODEL1310110044#

metaR FACOAL160i
name: C160 fatty acid activation
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
modifier: MODEL1310110044#

metaM HC01415 m
is: SBO:0000247
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: CHEBI:27537
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: (2E)-Octenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110044#_cf654f29_5283_41a3_bb4e_9e17f437fcbf
is encoded by: hsa:1103
has only substance units: false
constant: false
is: P28329
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: CHAT

metaM fadh2 r
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
has only substance units: false
is: SBO:0000247
name: FADH2(2-)
constant: false
initial concentration: 1.0
is: CHEBI:58307
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_45e8dd3b_07b3_45b7_8b6d_3e62b02d6582
is: Q92536
constant: false
type: Species
is encoded by: hsa:9057
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SLC7A6

metaR HMGCOAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
reversible: true

metaM dopa c
has only substance units: false
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
initial amount: NaN
type: Species
name: dopaminium(1+)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:59905

http://identifiers.org/biomodels.db/MODEL1310110044#_af634b8f_8755_4140_9abb_b5289976cd38
has only substance units: false
is encoded by: hsa:AA502753
initial concentration: NaN
name: _AA502753_1_m
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaM malttr e
name: maltotriose
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:27931
initial concentration: 1.0
is: C01835
constant: false
initial amount: NaN
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262

metaR r1259
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110044#
name: EC:6.2.1.3
reversible: false
reactant: MODEL1310110044#
type: Reaction
fast: false

metaM 2octdectecoa m
is: SBO:0000247
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaM coa r
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
initial concentration: 1.0
is: CHEBI:57287
constant: false
boundary condition: false
name: Coenzyme A
is: SBO:0000247

metaM datp m
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
is: C00131
type: Species
name: dATP
boundary condition: false
is: HMDB01532
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR CHSTEROLt1
name: cholesterol intracellular transport
is described by: ECO:0000304
fast: false
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_35dab65d_e55e_4149_83ba_0a7c79e53cfa
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8876
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: O95497
name: VNN1

metaR r0081
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
modifier: MODEL1310110044#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0dc52166_0279_4464_a09c_6c8eeb6612c3
initial amount: NaN
type: Species
has only substance units: false
is: P04745
initial concentration: NaN
name: AMY1B
is: SBO:0000252
is encoded by: hsa:277
boundary condition: true
constant: false

metaR FAOXC205C185m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_ca5d1a15_f12f_4c61_982d_1e9310f540a1
boundary condition: true
is encoded by: hsa:197257
type: Species
constant: false
is: Q86WU2
initial concentration: NaN
name: LDHD
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM 5mdr1p c
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
is: CHEBI:58533
is: HMDB00963
initial concentration: 1.0
constant: false
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
initial amount: NaN
is: C04188
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaM ca2 c
is: HMDB00464
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:29108
initial concentration: 1.0
name: calcium(2+)

http://identifiers.org/biomodels.db/MODEL1310110044#_6e6f2a52_6a6e_46c7_b49c_7992e87d6c68
is: P27707
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DCK
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1633

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110044#
fast: false
product: MODEL1310110044#
is: SBO:0000176

metaR r1318
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_4c0f5ec9_af6e_4ef9_baf7_4aa8e9fbe847
has only substance units: false
constant: false
name: _J03866_1_m
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:J03866
boundary condition: true
is: SBO:0000252

metaR r1576
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d7d84a52_e45e_4fb9_8924_b6b2e0c47794
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: AK2
is: P54819
is encoded by: hsa:204
initial concentration: NaN

metaR LYSOXp
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000176
fast: false
name: L-lysine oxidase, peroxisomal
reversible: false
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110044#_bf60b87e_34ac_467a_9a2c_c88b2c93015e
boundary condition: true
name: GLUD1
initial amount: NaN
type: Species
is: E9KL48
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:2746

metaR r0082
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.2
fast: false
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110044#
is: SBO:0000176

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM datp n
type: Species
initial concentration: 1.0
initial amount: NaN
name: dATP
constant: false
is: CHEBI:61404
is: SBO:0000247
has only substance units: false
is: HMDB01532
is: C00131
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

http://identifiers.org/biomodels.db/MODEL1310110044#_97cf1b24_9f9b_406f_9167_ba9d485cbf34
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P49753
has only substance units: false
type: Species
name: ACOT2
is encoded by: hsa:10965

http://identifiers.org/biomodels.db/MODEL1310110044#_9aa6d793_dcf7_44dc_8805_28b09343e7d1
is: O00750
initial amount: NaN
is encoded by: hsa:5287
name: PIK3C2B
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR CYSGLYexR
type: Reaction
reversible: true
name: L-cysteine/glycine reversible exchanger
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_4968df6c_886e_45d7_81cc_aec201c997c6
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
name: _HG2846_HT2983_1_m
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_dcb294a5_11e1_48cb_a599_2304d51090ab
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:4907
initial concentration: NaN
is: P21589
initial amount: NaN
is: SBO:0000252
name: NT5E

metaM ca2 e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: calcium(2+)
is: CHEBI:29108
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464

metaR r1579
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_80009ffa_9a85_4eb5_859b_3341359403be
is: SBO:0000252
constant: false
name: SLCO1C1
is: Q5JPA4
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:53919
has only substance units: false
type: Species

metaR PIPLC
reactant: MODEL1310110044#
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110044#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR r1257
fast: false
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: EC:6.2.1.3
reversible: false
is: SBO:0000176
reactant: MODEL1310110044#

metaR FAOXC121C10x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_cedd67f5_9403_49e7_a813_25e651bb56b8
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q9UBK5
has only substance units: false
initial concentration: NaN
name: HCST
initial amount: NaN
is encoded by: hsa:10870

metaR PECGCHLe
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR XYLUR
name: xylulose reductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.10
product: MODEL1310110044#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:

metaR CHSTEROLt3
fast: false
name: cholesterol intracellular transport
reversible: true
product: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110044#_9d6e7124_9986_408c_83e6_0de2f3ac0ef0
name: AK2
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:204
initial concentration: NaN

metaR r0541
reactant: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
product: MODEL1310110044#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_57dd9d98_5fa7_41c3_b9bd_d127ab9dde68
constant: false
is: Q3MHC9
has only substance units: false
is encoded by: hsa:23517
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SKIV2L2
initial amount: NaN
type: Species

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
name: 4-nitrophenolate
is: HMDB01232
has only substance units: false
is: CHEBI:57917
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaR RE2541E
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.2.1.31
name: RE2541
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaR MERCPLACCYSt
type: Reaction
fast: false
reversible: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000

metaR 5ADTSTSTERONESte
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
reversible: true
type: Reaction
name: sulfonated testosterone transport
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR LEUPHELAT2tc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR LSTO2r
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.14.21.6
kinetic law: MODEL1310110044#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
type: Reaction
modifier: MODEL1310110044#
reversible: false
name: Lathosterol oxidase

metaM dad 2 c
is: HMDB00101
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: CHEBI:17256
boundary condition: false

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaM leuktrB4 e
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
is: SBO:0000247
is: CHEBI:57461
name: leukotriene B4(1-)
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01085
initial amount: NaN

metaR r0002
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
product: MODEL1310110044#
fast: false
type: Reaction

metaR r1578
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR GLNS
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000254
name: glutamine synthetase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
modifier: MODEL1310110044#
type: Reaction

metaR ASPTA
is described by: ECO:0000269
modifier: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
name: aspartate transaminase
type: Reaction
kinetic law: MODEL1310110044#
fast: false
reversible: true
product: MODEL1310110044#

metaM arg L m
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:32682
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
name: L-argininium(1+)
is: SBO:0000247
initial amount: NaN

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM dump m
constant: false
has only substance units: false
name: dUMP(2-)
is: HMDB01409
type: Species
is: CHEBI:246422
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0

metaM bildglcur c
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
has only substance units: false
is: CHEBI:58471
is: HMDB03325
boundary condition: false
constant: false
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247

metaR CHSTEROLt2
name: cholesterol intracellular transport
fast: false
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM fad m
type: Species
has only substance units: false
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2e50f856_fb16_41d6_a226_dcace598f082
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: Q546Y9
is encoded by: hsa:57379
is: SBO:0000252
name: AICDA
constant: false
boundary condition: true

metaR DM anth
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_1cad8f80_d564_483a_97b6_fa09ece7fcd1
is: P00325
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:125
name: ADH1B
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR GGT6
name: Gamma-glutamyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
product: MODEL1310110044#
fast: false
reversible: true
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction

metaM bilirub c
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57977
is: HMDB00054
name: bilirubin(2-)
constant: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM udpglcur r
constant: false
initial amount: NaN
is: HMDB00935
is: CHEBI:58052
initial concentration: 1.0
name: UDP-D-glucuronate
type: Species
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
is: SBO:0000247
is: C00167

metaR DURAD
type: Reaction
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
fast: false
product: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
is described by: ECO:0000269
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaR r2359
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110044#_146e98b0_4952_4c88_ae78_18b097c1d546
constant: false
name: BAAT
has only substance units: false
is encoded by: hsa:570
is: SBO:0000252
type: Species
is: Q14032
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM coa n
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: coenzyme A(4-)
is: CHEBI:57287
is: HMDB01423
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
type: Species

metaM dump n
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: dUMP(2-)
is: SBO:0000247
constant: false
type: Species
is: CHEBI:246422
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2246f4b7_f3f6_4e5e_9316_f14e930c6383
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: DCXR
boundary condition: true
has only substance units: false
is: Q7Z4W1
is encoded by: hsa:51181

http://identifiers.org/biomodels.db/MODEL1310110044#_1173c401_cbbb_4571_8bbb_76dcf9fdf7fc
initial concentration: NaN
has only substance units: false
name: ENTPD1
is: Q86VV3
initial amount: NaN
is encoded by: hsa:953
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR r1573
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
is described by: ECO:0000000

metaR r0085
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000176

metaM leuktrB4 c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57461
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
name: leukotriene B4(1-)
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_7f941229_b09b_405c_96ef_7d400a83cc3c
has only substance units: false
type: Species
boundary condition: true
name: SLC12A7
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10723
is: Q9Y666

metaM fad r
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
name: Flavin adenine dinucleotide oxidized
boundary condition: false
is: HMDB01248
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16238
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_ea8cf2b9_f73f_44e2_8f71_b43f322625da
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P28329
name: CHAT
constant: false
is encoded by: hsa:1103
initial amount: NaN

metaR HSD17B42x
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
reversible: false
fast: false
is: SBO:0000176

metaR r2358
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR DUTPDPn
is version of: http://identifiers.org/ec-code/3.6.1.23
type: Reaction
is: SBO:0000176
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
fast: false
kinetic law: MODEL1310110044#
name: dUTP diphosphatase, nuclear

metaM glc D e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial amount: NaN
is: HMDB00122
type: Species

metaM coa m
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
is: C00010
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: Coenzyme A
is: CHEBI:57287
is: HMDB01423
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0635f70e_1b99_43a3_9bec_ad3ec87357d9
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q7Z725
initial amount: NaN
constant: false
name: SLC34A1
initial concentration: NaN
is encoded by: hsa:6569

http://identifiers.org/biomodels.db/MODEL1310110044#_6b7a1cf7_94b6_4940_a366_521451b0bf00
initial concentration: NaN
is encoded by: hsa:2679
initial amount: NaN
has only substance units: false
name: GGT3P
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15698
initial concentration: 1.0
is: HMDB00014
name: Deoxycytidine
initial amount: NaN
is: C00881
type: Species
boundary condition: false

metaR r1786
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110044#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_a7b69b76_77e3_4795_8417_a2c8c6527cd1
has only substance units: false
initial amount: NaN
is encoded by: hsa:6550
is: P48764
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: SLC9A3
boundary condition: true

metaR PI345P5P
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.86
fast: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reversible: false
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
is: SBO:0000176

metaR RE1709C
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE1709
reactant: MODEL1310110044#

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: SBO:0000247
is: CHEBI:57977
constant: false
has only substance units: false
is: HMDB00054
initial concentration: 1.0
type: Species
boundary condition: false
name: bilirubin(2-)

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d7851b22_20d8_4818_bfcc_0c70ca4fd2f5
initial concentration: NaN
boundary condition: true
name: PIK3R3
is encoded by: hsa:8503
is: SBO:0000252
constant: false
is: Q92569
has only substance units: false
type: Species
initial amount: NaN

metaR r0086
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_49ee9d42_ee9c_4816_baca_ed79a6fffc33
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: A1L4Q0
name: DGKE
is encoded by: hsa:8526
constant: false
boundary condition: true
is: SBO:0000252

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM andrstrn r
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial amount: NaN
type: Species
constant: false
is: CHEBI:16032
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: androsterone
is: HMDB00031
has only substance units: false

metaR PI45P5P
modifier: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
kinetic law: MODEL1310110044#
type: Reaction

metaR MCPST
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
is: SBO:0000176
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
type: Reaction
name: 3-mercaptopyruvate sulfurtransferase

metaR r0545
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
fast: false

metaM c226coa x
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: C16169
is: SBO:0000247
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479

http://identifiers.org/biomodels.db/MODEL1310110044#_9f75653e_58e2_48d9_9328_2ca5afcaea95
boundary condition: true
type: Species
is encoded by: hsa:39
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9BWD1
name: ACAT2
constant: false

metaM sphs1p r
boundary condition: false
initial concentration: 1.0
constant: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:60119

metaR RE3009C
kinetic law: MODEL1310110044#
fast: false
name: RE3009
reactant: MODEL1310110044#
type: Reaction
reversible: false
product: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_d98a6534_8736_464f_a750_afa1c510b93b
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC32A1
is: Q9H598
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:140679

metaM dtdp m
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
name: dTDP
is: C00363
is: CHEBI:58369
constant: false
initial concentration: 1.0
is: HMDB01274

metaR PHCHGSm
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110044#
reversible: true
is: SBO:0000176
fast: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_bf282976_7760_43ba_809f_c9d43690e7de
is: SBO:0000252
name: _AW277253_1_c
is encoded by: hsa:AW277253
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR ALCD2yf
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
is described by: ECO:0000134
reversible: false
is: SBO:0000176
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD

metaM dopa e
is: HMDB00073
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
type: Species
initial amount: NaN
is: CHEBI:59905
is: SBO:0000247
name: dopaminium(1+)

metaR NTD2m
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110044#
type: Reaction
reversible: false
product: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
is: SBO:0000176
name: 5'-nucleotidase (UMP), mitochondrial
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110044#

metaR r0083
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c0a125d0_cfc3_4c9a_ac42_068b1f9bfa5c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: P10696
is encoded by: hsa:251
boundary condition: true
has only substance units: false
type: Species
name: ALPPL2

http://identifiers.org/biomodels.db/MODEL1310110044#_644f37fd_2370_49fb_b5db_50da6024711f
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:206
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: _206_1_c

metaR r1575
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2200
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110044#
reversible: true

metaR VALTA
reactant: MODEL1310110044#
name: valine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
product: MODEL1310110044#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176

metaM dcyt c
is: HMDB00014
boundary condition: false
is: C00881
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
has only substance units: false
constant: false
is: CHEBI:15698
initial amount: NaN
name: Deoxycytidine
is: SBO:0000247

metaM glc D c
type: Species
initial amount: NaN
is: HMDB00122
has only substance units: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: SBO:0000247
is: CHEBI:4167
initial concentration: 1.0
boundary condition: false

metaM fadh2 m
name: Flavin adenine dinucleotide reduced
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C01352
is: CHEBI:58307
constant: false

metaM dtdp n
initial concentration: 1.0
boundary condition: false
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
is: CHEBI:58369
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false

metaM 2mop c
name: 2-methyl-3-oxopropanoate
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57700
constant: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
is: HMDB01172

metaM CE2417 m
type: Species
has only substance units: false
boundary condition: false
is: HMDB11123
initial amount: NaN
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: CHEBI:28387
constant: false

metaR r0084
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110044#
type: Reaction
fast: false
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reversible: true
product: MODEL1310110044#

metaR 2HBt2
modifier: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110044#
fast: false
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_a1e07ea4_72eb_475c_a8ca_ef5089f41c5c
has only substance units: false
constant: false
name: CHKA
initial amount: NaN
is: SBO:0000252
is: P35790
is encoded by: hsa:1119
boundary condition: true
initial concentration: NaN
type: Species

metaR r1574
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_bc340734_7889_4e97_8e71_5916d87faf5f
initial concentration: NaN
has only substance units: false
type: Species
is: P00491
is: SBO:0000252
initial amount: NaN
name: PNP
boundary condition: true
is encoded by: hsa:4860
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_4fc01313_694a_4d97_ae36_5f84bb443135
is: Q9HBH5
initial concentration: NaN
is encoded by: hsa:57665
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: RDH14
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_1d36f401_84f5_404f_bca9_263c5840057c
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: SLC26A1
is: SBO:0000252
is encoded by: hsa:10861
is: Q9H2B4

metaM mag hs e
constant: false
name: monoacylglycerol 2
initial amount: NaN
has only substance units: false
is: CHEBI:32391
is: HMDB03073
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
type: Species

metaR ADNCYC
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.6.1.1
is: SBO:0000176
reversible: false
name: adenylate cyclase
modifier: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110044#_81488e0b_8689_45dd_a256_b992e70c3e6c
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GGT2
is encoded by: hsa:728441
type: Species

metaR HEXDICOAACBPx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c096c991_9d5a_4202_988c_ef1546864e43
has only substance units: false
initial amount: NaN
is: B4DDW0
type: Species
is: SBO:0000252
initial concentration: NaN
name: RDH11
constant: false
boundary condition: true
is encoded by: hsa:51109

metaM 5htrp c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 5-hydroxy-L-tryptophan
is: CHEBI:17780
is: HMDB00472
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_f157a6a1_ec97_4542_a5c1_e287c9a6a5fc
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5730
initial concentration: NaN
is: P41222
is: SBO:0000252
name: PTGDS

metaR PHEtec
fast: false
notes: GENE_ASSOCIATION: (117247.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
name: L-phenylalanine transport via diffusion (extracellular to cytosol)
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_95d0b6ed_fd13_4ee8_854d_a2cd624c499b
name: PIK3R5:PIK3CG
constant: false
initial amount: NaN
has part: Q8WYR1
type: Species
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23533
boundary condition: true

metaM lnlc r
is: SBO:0000247
is: HMDB00673
has only substance units: false
boundary condition: false
name: linoleate
initial amount: NaN
is: CHEBI:30245
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_90d0d03c_6905_43db_a070_f1b6aeca3412
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9NT06
is encoded by: hsa:54511
name: HMGCLL1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_6dd1c490_6a05_41d8_a6e4_29b364f64a00
name: INPP5B
is encoded by: hsa:3633
initial concentration: NaN
is: P32019
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM thymd e
is: CHEBI:17748
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
is: HMDB00273

metaR RETNGLCt2
name: retinoyl glucuronide efflux (13-cis)
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:14704335,PMID:2324641 NOTES:IT
reversible: false
reactant: MODEL1310110044#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_4dacc6ad_4378_4101_840e_bf38f67b0c0a
constant: false
type: Species
is: Q16348
name: SLC15A2
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6565
has only substance units: false
is: SBO:0000252

metaM inost c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268
constant: false
has only substance units: false
type: Species
is: HMDB00211
initial amount: NaN
is: SBO:0000247
name: myo-inositol

http://identifiers.org/biomodels.db/MODEL1310110044#_39a2e006_6fdd_4442_861e_7c63c958321f
is: SBO:0000252
name: AICDA
has only substance units: false
constant: false
is encoded by: hsa:57379
is: Q546Y9
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_11613613_c0c0_4636_9193_f76c555a7c9a
constant: false
is: SBO:0000252
is encoded by: hsa:3099
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P52789
name: HK2

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is described by: ECO:0000000

metaR r1811
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_7ff9a915_ae75_4563_a863_21e1707f5d48
boundary condition: true
constant: false
is encoded by: hsa:AV717590
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AV717590_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_de66f431_2b08_4e20_a6e7_8c98c8cc1eb7
type: Species
has only substance units: false
name: UGT1A10
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9HAW8
boundary condition: true
is encoded by: hsa:54575

http://identifiers.org/biomodels.db/MODEL1310110044#_39aeebaa_a210_415b_a0b5_66805cd30d2b
name: _AF116616_1_m
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AF116616
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c7150efe_7df9_4903_abb9_4a742ffdc289
is: Q9UN76
is encoded by: hsa:11254
initial concentration: NaN
boundary condition: true
name: SLC6A14
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM o2 c
is: HMDB01377
type: Species
boundary condition: false
is: CHEBI:15379
has only substance units: false
constant: false
is: SBO:0000247
is: C00007
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2

http://identifiers.org/biomodels.db/MODEL1310110044#_93675c64_f0bd_4303_b27d_2d6562735613
name: ADSSL1
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:122622
initial concentration: NaN
is: B3KTV4

metaR GK1
is described by: ECO:0000269
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8

http://identifiers.org/biomodels.db/MODEL1310110044#_fdca264b_b2c3_451c_a19f_2cf080547a5d
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:8525
initial concentration: NaN
is: B7Z2M9
has only substance units: false
name: DGKZ

metaR PAIL4P HStn
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reversible: true

metaM fad e
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00016
is: HMDB01248
initial concentration: 1.0
is: CHEBI:16238
initial amount: NaN
name: Flavin adenine dinucleotide oxidized

http://identifiers.org/biomodels.db/MODEL1310110044#_88aa1581_80a5_467f_b292_967f2b49958b
has only substance units: false
name: NDUFB6
is: SBO:0000252
is: O95139
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4712

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR SPHK21c
name: sphingosine kinase 2
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.91
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_13eea0e3_af30_4586_8f7f_2e4a1311a68f
initial concentration: NaN
initial amount: NaN
is: Q308M7
name: ENPP3
is encoded by: hsa:5169
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaR RPI
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribose-5-phosphate isomerase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.6
is: SBO:0000176
product: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_95563588_dbb6_4133_945b_1595406a2997
is: SBO:0000252
initial amount: NaN
is: A6NFM2
boundary condition: true
name: PYCR1
has only substance units: false
constant: false
is encoded by: hsa:5831
initial concentration: NaN
type: Species

metaM thymd c
is: SBO:0000247
is: C00214
name: Thymidine
initial concentration: 1.0
is: CHEBI:17748
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB00273

http://identifiers.org/biomodels.db/MODEL1310110044#_680a7658_c160_40df_b652_6c188bb16bc9
boundary condition: true
has only substance units: false
type: Species
has part: E7EX19
is: SBO:0000297
is encoded by: hsa:5295
initial concentration: NaN
initial amount: NaN
constant: false
name: PIK3CD:PIK3R1

http://identifiers.org/biomodels.db/MODEL1310110044#_645384f5_fe0f_4b67_9c07_8a8c8ea19f22
name: AK4
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:205
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_43fdec68_3805_4b60_b972_8847b3843dbe
is encoded by: hsa:8883
is: SBO:0000252
is: A8MU28
initial concentration: NaN
boundary condition: true
name: NAE1
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_f7be4703_0152_447d_b075_c1f2291a6000
is encoded by: hsa:5136
name: PDE1A
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q9Y633
constant: false

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268
type: Species
is: HMDB00211
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: myo-inositol

metaM thp2c x
type: Species
constant: false
is: HMDB12130
name: 1-piperideine-6-carboxylate
initial amount: NaN
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_ff4e071d_90a9_4cff_96c4_e8aa9c4ff394
boundary condition: true
is: SBO:0000252
name: SLC6A9
is encoded by: hsa:6536
is: B7Z3W8
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_481cc533_8b74_480d_93c0_83075bc9b494
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN
type: Species
is: Q02218
has only substance units: false
name: OGDH
constant: false
is: SBO:0000252

metaM chsterol l
is: SBO:0000247
name: cholesterol
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9712b0f9_0a34_47a8_9611_69abae40118b
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: F5H066
is encoded by: hsa:6560
boundary condition: true
initial amount: NaN
name: SLC12A4

metaR MECOAS1m
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is described by: ECO:0000304
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_5a731668_fee2_4cb6_b14b_0d6fa088bce2
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5167
has only substance units: false
name: ENPP1
is: P22413

metaM udp r
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: UDP
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: C00015
is: HMDB00295

http://identifiers.org/biomodels.db/MODEL1310110044#_2d6aed48_506b_49d4_a9f0_2b9241066bad
is encoded by: hsa:5153
is: Q7Z364
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: PDE1B

http://identifiers.org/biomodels.db/MODEL1310110044#_b7f68a3a_de86_4ba8_ba38_3ad9e70ac6f1
boundary condition: true
constant: false
is: Q6PXP3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:155184
initial amount: NaN
type: Species
name: SLC2A7
initial concentration: NaN

metaR PE HSter
type: Reaction
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false

metaR GLCter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110044#
name: glucose transport, endoplasmic reticulum
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
reversible: true

metaM mev R c
has only substance units: false
name: (R)-mevalonate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36464
is: SBO:0000247
type: Species
is: HMDB00227
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
boundary condition: false
constant: false

metaM fadh2 x
is: HMDB01197
name: FADH2(2-)
boundary condition: false
initial amount: NaN
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

metaM cholcoa c
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
name: choloyl-CoA(4-)
is: CHEBI:57373
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_7362b9a2_6cb8_4c55_9233_020276d11252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:125965
is: SBO:0000252
name: COX6B2
is: Q6YFQ2

metaR PI34P5K
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110044#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
product: MODEL1310110044#
fast: false
reversible: false
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110044#

metaM fmn c
is: HMDB01520
name: FMN
initial amount: NaN
is: CHEBI:58210
constant: false
initial concentration: 1.0
has only substance units: false
is: C00061
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
type: Species

metaR CMPACNAtn
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
name: CMP-Sia nuclear export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110044#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_cfa72248_7930_4117_8e4f_566e7e7285fb
has only substance units: false
name: ACHE
is: P22303
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:43
boundary condition: true
initial amount: NaN
type: Species

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM dlnlcgcoa c
is: CHEBI:27979
has only substance units: false
initial concentration: 1.0
constant: false
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

http://identifiers.org/biomodels.db/MODEL1310110044#_b56ae1de_5b03_434d_9eff_f4bbfb33db13
is encoded by: hsa:2618
is: P22102
name: GART
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaR r1568
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#

metaM chsterol m
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
is: SBO:0000247
has only substance units: false
is: CHEBI:16113
type: Species
is: HMDB00067
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaM bildglcur e
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB03325
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
type: Species
is: CHEBI:58471
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_c9cbe762_46a4_4e43_a248_254e032819d0
name: INPP5E
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9NRR6
type: Species
is encoded by: hsa:56623
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a0a4837c_d0f0_427f_ab45_54d9d279731d
type: Species
has only substance units: false
is: O14975
name: SLC27A2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11001
constant: false
boundary condition: true
initial concentration: NaN

metaM e4p c
initial concentration: 1.0
type: Species
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: CHEBI:16897
is: C00279
is: HMDB01321
boundary condition: false
name: D-Erythrose 4-phosphate
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM CE2422 m
type: Species
has only substance units: false
constant: false
is: CHEBI:28387
is: HMDB11123
is: SBO:0000247
initial amount: NaN
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
boundary condition: false

metaM dcmp c
is: HMDB01202
type: Species
name: dCMP
is: SBO:0000247
is: CHEBI:57566
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
initial amount: NaN
is: C00239
boundary condition: false
initial concentration: 1.0

metaR FRDPtc
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
name: lipid, flip-flop intracellular transport
fast: false
is: SBO:0000185
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e759275c_418f_4758_ba51_932a5f387414
is: SBO:0000252
is: Q14032
has only substance units: false
is encoded by: hsa:570
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: BAAT
type: Species

metaM cholate e
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: Cholate
type: Species
is: HMDB00619
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
is: CHEBI:29747

http://identifiers.org/biomodels.db/MODEL1310110044#_e44f0a87_dbca_45db_8428_38e52906fde0
constant: false
name: COX7B
has only substance units: false
is: P24311
boundary condition: true
initial amount: NaN
is encoded by: hsa:1349
type: Species
is: SBO:0000252
initial concentration: NaN

metaR ACS
reversible: false
is: SBO:0000176
modifier: MODEL1310110044#
fast: false
type: Reaction
name: acetyl-CoA synthetase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.16
notes: GENE_ASSOCIATION: (65985.1) or (55902.2) or (55902.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 4 AUTHORS: PMID:10843999,PMID:12623130 NOTES:
reactant: MODEL1310110044#

metaR O2t
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)
type: Reaction
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_6688f119_71ff_4abd_8bb4_70e5cf3c5656
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: O14732
is: SBO:0000252
is encoded by: hsa:3613
has only substance units: false
boundary condition: true
name: IMPA2

metaM pac c
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:18401
constant: false
name: phenylacetate
is: HMDB00209
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086

metaM HC01162 c
is: CHEBI:58376
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110044#_4ffaf432_c1d9_483c_aee5_a7fc3381f71f
type: Species
is encoded by: hsa:33
has only substance units: false
initial concentration: NaN
is: P28330
constant: false
name: ACADL
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR TDCHOLAte
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110044#
type: Reaction
name: bile acid intracellular transport
reactant: MODEL1310110044#
fast: false
is: SBO:0000185

metaR r1569
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a43ff669_3cd5_454d_8920_1d894ea8ffa4
is encoded by: hsa:54407
name: SLC38A2
constant: false
initial concentration: NaN
initial amount: NaN
is: Q96QD8
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM thyox L e
is: HMDB00248
initial amount: NaN
name: L-thyroxine
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
type: Species
is: CHEBI:18332

metaR r0998
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_d268b376_e396_4168_ab3b_a865362723f9
initial amount: NaN
boundary condition: true
name: CDIPT
is encoded by: hsa:10423
constant: false
has only substance units: false
is: O14735
type: Species
is: SBO:0000252
initial concentration: NaN

metaM fmn e
constant: false
is: CHEBI:58210
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
is: C00061
has only substance units: false
is: HMDB01520
boundary condition: false
type: Species
initial amount: NaN

metaR ADSS
is version of: http://identifiers.org/ec-code/6.3.4.4
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is: SBO:0000176
modifier: MODEL1310110044#
reversible: false
type: Reaction
name: adenylosuccinate synthase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110044#_8172458d_b870_45af_bb04_f1c908c850f9
constant: false
name: GPD1
is: F8W1L5
has only substance units: false
is encoded by: hsa:2819
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR RPE
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: ribulose 5-phosphate 3-epimerase
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reactant: MODEL1310110044#
is: SBO:0000176
fast: false

metaR FAOXC185C164m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_fa6fdc9b_f09f_4e75_b2ea_0cfbf5a90fff
name: _AI971036_1_x
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI971036
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR SPC HSt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reactant: MODEL1310110044#
is: SBO:0000185
name: sphingosylphosphorylcholine transport (diffusion)
kinetic law: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
fast: false

metaR CDIPTr
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is: SBO:0000176
type: Reaction
name: phosphatidylinositol synthase (Homo sapiens)
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.8.11
kinetic law: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_5c3cb6b9_823c_4822_baa8_b6e7b0f43ba6
is: O95622
initial concentration: NaN
type: Species
has only substance units: false
name: ADCY5
initial amount: NaN
is encoded by: hsa:111
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_2ea1a0c9_ae6f_4e82_907b_5b8506c3c426
name: SLC22A2
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6582
is: O15244

http://identifiers.org/biomodels.db/MODEL1310110044#_60884c99_573d_4661_9df1_47254142ce77
type: Species
name: SYNJ2
boundary condition: true
has only substance units: false
is encoded by: hsa:8871
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O15056
constant: false

metaM Rtotal e
boundary condition: false
name: R total
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
is: HMDB00244
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: C00255
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110044#_9fcf6010_5f67_4c6a_b987_7c1ac0bd086c
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:10870
is encoded by: hsa:5294
boundary condition: true
has part: P48736
has only substance units: false
has part: Q9UBK5
name: HCST:PIK3CG
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_62fe50b9_390c_42c2_9fc5_fca7d231163e
initial concentration: NaN
name: SLC2A11
type: Species
has only substance units: false
is encoded by: hsa:66035
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q8WXF9

metaR r0999
is described by: ECO:0000000
fast: false
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110044#

metaM citr L m
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
is: CHEBI:16349
initial amount: NaN
type: Species
has only substance units: false
name: L-citrulline
is: HMDB00904
is: SBO:0000247
boundary condition: false

metaR MI1PP
name: myo-inositol 1-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
reversible: false
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000269

metaM Rtotal c
is: CHEBI:16349
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
name: R total
has only substance units: false
boundary condition: false
type: Species
constant: false
is: HMDB00904

metaM HC00342 m
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
boundary condition: false
name: cis-aconitate(3-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16383

metaR 2MCITt
fast: false
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: 2-methylcitrate transport via diffusion
reactant: MODEL1310110044#

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_3e1a64f5_1691_4c9c_adf9_f60c770f6dea
constant: false
is: P15954
has only substance units: false
name: COX7C
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1350
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_bc00ef5f_1646_4865_9b99_3d447dbd0e6c
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI480132
name: _AI480132_1_c
constant: false
has only substance units: false
initial concentration: NaN

metaR HISTAtu
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
name: Histamine uniport

http://identifiers.org/biomodels.db/MODEL1310110044#_27f75196_2148_41dc_9f44_863c1d5120e3
initial amount: NaN
has only substance units: false
name: _BE966236_1_c
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:BE966236
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_4701dcfa_19ea_4fc6_bdbf_d467ea54ee2e
initial amount: NaN
is encoded by: hsa:5140
is: SBO:0000252
boundary condition: true
name: PDE3B
type: Species
is: A7E2E5
has only substance units: false
initial concentration: NaN
constant: false

metaR FAOXC225m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR ORPT
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.4.2.10
modifier: MODEL1310110044#
fast: false
name: orotate phosphoribosyltransferase
is: SBO:0000176

metaM sebcoa x
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
name: sebacoylcoa
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
type: Species

metaM gmp c
is: SBO:0000247
has only substance units: false
is: HMDB01397
is: CHEBI:58115
is: C00144
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
constant: false
initial concentration: 1.0
name: GMP
boundary condition: false
type: Species

metaR 4ABUTtcn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110044#
name: transport of GABA

metaM 56dura c
boundary condition: false
is: CHEBI:15901
has only substance units: false
is: HMDB00076
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
constant: false
is: SBO:0000247
name: 5,6-dihydrouracil
initial concentration: 1.0
type: Species
initial amount: NaN

metaM aps c
has only substance units: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
type: Species
is: CHEBI:58243
initial amount: NaN
name: 5'-adenylyl sulfate(2-)
constant: false
is: HMDB01003
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r1459
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Transport reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

metaM udp m
initial amount: NaN
constant: false
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB00295
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fbbbb96a_3e99_4d3a_a2a5_3f7070fdbb3a
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3417
initial concentration: NaN
is: O75874
name: IDH1

metaR r0655
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
kinetic law: MODEL1310110044#
is: SBO:0000176
modifier: MODEL1310110044#
type: Reaction
reversible: true

metaM forglu c
is: C00439
is: CHEBI:18327
type: Species
has only substance units: false
is: HMDB00854
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
constant: false
name: N-Formimidoyl-L-glutamate
is: SBO:0000247

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
product: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reversible: true
fast: false
is described by: ECO:0000269
modifier: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_740e916e_6ef0_4b6a_adb7_35a3526a25f9
type: Species
name: SGPP2
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:130367
is: Q8IWX5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_6469e19d_0bfa_4e29_a111_29191601685f
is: Q9UBF8
boundary condition: true
initial amount: NaN
type: Species
name: PI4KB
constant: false
is: SBO:0000252
is encoded by: hsa:5298
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_1517974d_d8cc_4753_a04b_bd00030ab1c8
is encoded by: hsa:AF080579
has only substance units: false
initial amount: NaN
name: _AF080579_1_c
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR r0330
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_cc909001_44d0_4c3f_9b9f_6e8e7778a51e
boundary condition: true
is: Q6LEN5
is encoded by: hsa:1103
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: CHAT
initial amount: NaN
is: SBO:0000252

metaR r2372
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_a539a5a5_dc80_4f63_a230_c0e949abb72e
initial concentration: NaN
type: Species
name: GMPR2
has only substance units: false
is: SBO:0000252
is: Q86T14
initial amount: NaN
constant: false
is encoded by: hsa:51292
boundary condition: true

metaM thyox L c
initial concentration: 1.0
name: L-thyroxine
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:18332
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_6216d107_370f_4d1d_a8c8_08695eb07bec
is encoded by: hsa:1717
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9UBM7
initial amount: NaN
name: DHCR7
constant: false

metaR r1106
is: SBO:0000185
fast: false
name: Postulated transport reaction
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true

metaM mi134p c
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: SBO:0000247
initial concentration: 1.0
is: HMDB01143
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
constant: false
is: CHEBI:58414
has only substance units: false
boundary condition: false
type: Species

metaR RE1527M
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: RE1527

metaM HC01712 m
is: SBO:0000247
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: S-Glutaryldihydrolipoamide
has only substance units: false
initial concentration: 1.0
is: CHEBI:28391

http://identifiers.org/biomodels.db/MODEL1310110044#_1a36e2a3_9241_47a8_b7bd_a06a0fe1c4d5
has only substance units: false
initial concentration: NaN
is: Q9NVE7
type: Species
is encoded by: hsa:55229
initial amount: NaN
name: PANK4
is: SBO:0000252
constant: false
boundary condition: true

metaR r0656
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110044#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction

metaR ALAGLNexR
is described by: ECO:0000304
type: Reaction
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110044#
fast: false
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185

metaR RE1533M
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: RE1533
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110044#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR INSTt2r
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000269
name: inositol transport in via proton symport
is: SBO:0000185
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_26edb111_d3da_4936_8218_c589cef1264f
is: SBO:0000252
is: P07195
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: LDHB
boundary condition: true
is encoded by: hsa:3945
constant: false

metaM pail5p hs n
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false

metaM glutcoa m
type: Species
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57378
name: glutaryl-CoA(5-)
is: HMDB01339
initial amount: NaN
has only substance units: false
boundary condition: false

metaM leuktrC4 c
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
name: leukotriene C4(2-)
boundary condition: false

metaR CYTK7n
modifier: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
product: MODEL1310110044#
name: cytidylate kinase (CMP,UTP),nuclear
reactant: MODEL1310110044#

metaR r2373
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction

metaM f6p c
is: http://identifiers.org/pubchem.compound/3385
boundary condition: false
has only substance units: false
is: HMDB00124
is: SBO:0000247
is: CHEBI:57579
is: C00085
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-Fructose 6-phosphate
constant: false

metaM s7p c
is: C05382
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
name: Sedoheptulose 7-phosphate
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57483
is: HMDB01068
is: SBO:0000247

metaR ILEPHELAT2tc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR PPNCL3
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110044#
name: phosphopantothenate-cysteine ligase
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110044#
is: SBO:0000176

metaR FAS160COA
fast: false
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000176
reversible: false
reactant: MODEL1310110044#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM retfa e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:15963
initial amount: NaN
name: fatty acid retinol
is: HMDB00508
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_a8e07db7_5bd4_4b2b_b442_ec2fd3bb083c
name: PECR
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9BY49
initial amount: NaN
constant: false
is encoded by: hsa:55825

metaR r0653
type: Reaction
product: MODEL1310110044#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7e65f800_98d1_4e92_9400_1609c30249e0
name: SLC25A14
boundary condition: true
is encoded by: hsa:9016
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_7138a851_ab89_4d09_bb6f_65dc2c0b8709
type: Species
is: Q6AI14
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC9A4
constant: false
initial amount: NaN
is encoded by: hsa:389015
has only substance units: false

metaM HC01522 c
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:28508
name: Gentisate aldehyde
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_bbead7f1_b74f_47b6_8a0a_280e045b8035
is: SBO:0000252
is encoded by: hsa:6582
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: SLC22A2
initial concentration: NaN

metaM xylt c
constant: false
is: CHEBI:17151
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
is: HMDB02917
boundary condition: false

metaR r0994
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Facilitated diffusion

metaR ASPDTDe
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
product: MODEL1310110044#
type: Reaction
name: D-aspartate transport, extracellular
is: SBO:0000185
reversible: true

metaM C04849 e
boundary condition: false
is: CHEBI:57449
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_10ee9433_a3d6_4b11_8a21_71368a0568b3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q53H96
is encoded by: hsa:65263
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: PYCRL

http://identifiers.org/biomodels.db/MODEL1310110044#_abfea51c_ea83_4eae_87fc_d7dc2a9d1f25
is: SBO:0000252
name: HAL
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: B4E0V8
is encoded by: hsa:3034
has only substance units: false
constant: false

metaM tdchola x
initial amount: NaN
name: taurochenodeoxycholate
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:9407
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951

metaM ppi x
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
boundary condition: false
is: HMDB00250
is: CHEBI:33019
is: C00013
type: Species
constant: false
has only substance units: false
is: SBO:0000247
name: Diphosphate

metaR r2371
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR PTPAT
kinetic law: MODEL1310110044#
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
reactant: MODEL1310110044#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
is described by: ECO:0000269
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8884a16c_0099_4db6_b72b_08428a5b25e3
constant: false
boundary condition: true
name: PI4KA
is encoded by: hsa:5297
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B4DYG5
is: SBO:0000252
type: Species

metaR AMPtp
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110044#
fast: false
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
name: AMP transporter, peroxisome

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR r0842
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.1.72
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
name: Postulated transport reaction
fast: false
kinetic law: MODEL1310110044#

metaM chsterol c
has only substance units: false
is: CHEBI:16113
is: HMDB00067
name: cholesterol
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaM 7dhchsterol r
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17759
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00032
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_eda9d841_198f_41f5_8da7_e03f1318df06
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5150
is: Q13946
initial amount: NaN
boundary condition: true
type: Species
name: PDE7A
is: SBO:0000252

metaM o2 e
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
constant: false
is: HMDB01377
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:15379
is: SBO:0000247
is: C00007
type: Species
name: O2

metaM fad c
is: HMDB01248
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Flavin adenine dinucleotide oxidized
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
boundary condition: false

metaM mercplac c
is: http://identifiers.org/pubchem.compound/8118
name: 3-Mercaptolactate
type: Species
constant: false
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
initial concentration: 1.0
is: C05823
has only substance units: false
is: HMDB02127
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_55eb3522_fabd_4d61_98e6_39dc0586f52b
constant: false
name: GPX5
is: SBO:0000252
initial concentration: NaN
is: O75715
is encoded by: hsa:2880
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR PRPPS
name: phosphoribosylpyrophosphate synthetase
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
fast: false

metaM citr L c
name: L-citrulline
is: CHEBI:16349
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
is: HMDB00904
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a047331e_0c7c_4d09_985e_4c658fa98fd1
name: RRM2
is: SBO:0000252
is: P31350
is encoded by: hsa:6241
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR FAOXC102m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM L2aadp c
name: L-2-aminoadipate(1-)
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00510
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

http://identifiers.org/biomodels.db/MODEL1310110044#_647d154d_59a1_4dc1_ace3_3b9eae2138e7
constant: false
is: Q13057
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: COASY
initial amount: NaN
is encoded by: hsa:80347
boundary condition: true
type: Species

metaM gluala e
is: http://identifiers.org/pubchem.compound/6503
has only substance units: false
constant: false
is: C03740
name: 5-L-Glutamyl-L-alanine
is: HMDB06248
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247
initial amount: NaN

metaR O2tm
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8b4923b7_5a36_4be6_9e14_0bc3750e4186
initial amount: NaN
name: DLD
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P09622
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1738

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: Mesaconyl-CoA
is: C06028
is: CHEBI:27969
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_1383f884_050b_4eda_b633_d9fad971f051
is encoded by: hsa:123041
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: SLC24A4
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110044#
reversible: true
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_dc6dde7b_1ee6_4eb4_9beb_28f8e58a0493
boundary condition: true
has only substance units: false
is: A8K5J1
is: SBO:0000252
is encoded by: hsa:7372
constant: false
type: Species
name: UMPS
initial concentration: NaN
initial amount: NaN

metaR SERDGLNexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000304
modifier: MODEL1310110044#
reversible: true
name: D-Serine/Glutamine reversible exchange
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e96329dc_3c75_4dc7_abbf_a72f25c249e8
initial concentration: NaN
is encoded by: hsa:57468
initial amount: NaN
name: SLC12A5
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q9H2X9

metaR r0652
fast: false
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#

metaR ADSK
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
name: adenylyl-sulfate kinase

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM chsterol e
is: HMDB00067
is: CHEBI:16113
has only substance units: false
initial concentration: 1.0
type: Species
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR RE3006M
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
reactant: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM HC00342 c
is: SBO:0000247
constant: false
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: cis-aconitate(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_00e4d75b_7280_4171_b3e3_8d661555f3c6
has only substance units: false
boundary condition: true
is encoded by: hsa:8659
constant: false
is: P30038
initial concentration: NaN
initial amount: NaN
name: ALDH4A1
is: SBO:0000252
type: Species

metaM h2o2 x
is: CHEBI:16240
is: HMDB03125
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Hydrogen peroxide
constant: false
has only substance units: false
boundary condition: false
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN

metaR PGLYCt
reactant: MODEL1310110044#
fast: false
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
is: SBO:0000185
reversible: true
name: phosphatidylglycerol transport

metaM citr L e
is: CHEBI:16349
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00904
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: citr_L[e]
boundary condition: false

metaR O2tp
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
name: O2 transport, peroxisomal
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR GGH 10FTHF6GLUe
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
reversible: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_d7e84972_f1ce_4df4_b300_e5ebb7c5712e
is: O00483
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:4697
name: NDUFA4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_659b0404_6b94_4630_9023_6d4afa2f5815
name: ALDH7A1
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:501
type: Species
boundary condition: true
is: E7EPT3
has only substance units: false
initial amount: NaN

metaM accoa c
constant: false
type: Species
name: Acetyl-CoA
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
is: HMDB01206
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00024
has only substance units: false

metaM 3octpencoa m
constant: false
name: 3,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110044#_de2660b6_9417_4781_97ec_ef036d798f7f
constant: false
is: P49619
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: DGKG
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1608

metaM oaa c
is: CHEBI:3338
boundary condition: false
initial amount: NaN
is: HMDB00223
constant: false
is: SBO:0000247
name: Oxaloacetate
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species
is: C00036
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_9c6df40f_cb28_47fd_a481_948852c8b342
initial amount: NaN
name: _728226_1_e
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:728226
type: Species
is: SBO:0000252
has only substance units: false

metaM dcholcoa c
has only substance units: false
is: HMDB06292
type: Species
initial concentration: 1.0
constant: false
name: chenodeoxycholoyl coenzyme a
boundary condition: false
is: CHEBI:28701
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN

metaR KHte
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: KHte
fast: false

metaR PPAm
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
type: Reaction
name: inorganic diphosphatase
is described by: ECO:0000269
kinetic law: MODEL1310110044#
reversible: false
fast: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR UNK2
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: 2-keto-4-methylthiobutyrate transamination
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false

metaM udp n
is: HMDB00295
name: UDP(3-)
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: CHEBI:58223
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_5cf3d844_5f4a_45e8_a3da_6e6336676a15
type: Species
has only substance units: false
name: NDUFA4L2
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:56901
is: SBO:0000252
is: Q9NRX3
boundary condition: true

metaR LDH L
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
name: L-lactate dehydrogenase
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_1dfe23e1_e116_4695_a238_e573ed63d2cc
name: _2544_1_c
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2544
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_2bb0be81_b674_482c_9600_631dfd8dc961
has only substance units: false
is: Q8IX04
is encoded by: hsa:55293
initial concentration: NaN
name: UEVLD
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r0196
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
type: Reaction
product: MODEL1310110044#
fast: false
is: SBO:0000176
modifier: MODEL1310110044#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_ef1e0506_5923_41ed_b79c_c808f5b0a51d
is: SBO:0000252
constant: false
name: MVD
is: P53602
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4597
initial amount: NaN
boundary condition: true

metaR r0650
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110044#
fast: false
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110044#
is: SBO:0000176

metaR GHMT2r
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible
product: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
reversible: true

metaM dcmp n
name: dCMP(2-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
type: Species
boundary condition: false

metaR r0464
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3

metaR r0946
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_ec33b0c4_a851_45fa_8828_c8665232e728
is encoded by: hsa:4709
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: NDUFB3
initial concentration: NaN
is: Q6IB80
constant: false

metaM ser D e
has only substance units: false
boundary condition: false
name: D-serine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
is: SBO:0000247
constant: false
is: CHEBI:16523
type: Species

metaR UMPK3n
reactant: MODEL1310110044#
reversible: true
product: MODEL1310110044#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM dgmp c
constant: false
is: CHEBI:57673
initial concentration: 1.0
name: dGMP
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01044
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_38bff252_ab20_460d_8e87_0d96a2535b43
name: PANK3
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79646
type: Species
is: SBO:0000252
is: Q9H999
boundary condition: true

metaR ABUTt2r
fast: false
is described by: ECO:0000304
modifier: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaR DAGK hs
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110044#
name: Diacylglycerol phosphate kinase (homo sapiens)

http://identifiers.org/biomodels.db/MODEL1310110044#_a0bcb96a_1aaf_47f5_bb5d_efd731f6a489
constant: false
initial amount: NaN
type: Species
name: ALPI
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:248
is: P09923
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_8f1d4791_1010_48e2_8ab2_344499535ec7
constant: false
has only substance units: false
boundary condition: true
name: PCBD1
is: P61457
type: Species
is encoded by: hsa:5092
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM 56dthm c
is: HMDB00079
is: SBO:0000247
name: 5,6-dihydrothymine
constant: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
has only substance units: false
initial concentration: 1.0
is: CHEBI:27468
type: Species
boundary condition: false
initial amount: NaN

metaR CO2tm
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
name: CO2 transport (diffusion), mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR r2401
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR TCHOLAte
product: MODEL1310110044#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false

metaM asn L c
is: CHEBI:17196
boundary condition: false
name: L-asparagine
initial concentration: 1.0
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: HMDB00168
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_9e1cac0e_db82_4c38_9990_bb09331560d3
is encoded by: hsa:6520
constant: false
initial concentration: NaN
has part: Q9NS82
is encoded by: hsa:56301
type: Species
has part: P08195
has only substance units: false
is: SBO:0000297
boundary condition: true
name: SLC7A10:SLC3A2
initial amount: NaN

metaR RE3624M
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110044#
name: RE3624
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r0463
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reactant: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
type: Reaction
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaM q10h2 m
boundary condition: false
is: HMDB13111
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial concentration: 1.0
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740

http://identifiers.org/biomodels.db/MODEL1310110044#_b83d8a6d_2a7a_42e1_8193_6229bee7edf8
is: Q86YI5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1737
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: DLAT
boundary condition: true

metaM HC02179 e
constant: false
name: 20-hydroxy-arachidonate
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM leuktrE4 e
is: CHEBI:57462
name: leukotriene E4(1-)
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_362312a5_7efe_42c5_9fcb_037f0f38df04
name: BCKDHB
initial concentration: NaN
initial amount: NaN
is: P21953
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:594

http://identifiers.org/biomodels.db/MODEL1310110044#_d03fde85_0b00_46dc_b92e_f8b06cac0421
name: CHKB
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1120
type: Species
is: Q9Y259
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_286c9831_cecb_4f59_8e15_6e0ec3be1e8e
name: _AU149534_1_e
initial amount: NaN
constant: false
is encoded by: hsa:AU149534
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_09407962_60d0_49f3_9709_045b0452cd8e
initial concentration: NaN
boundary condition: true
is: C9JFZ1
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: SYNJ1
is encoded by: hsa:8867
is: SBO:0000252

metaR RE3520E
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
reversible: true
name: RE3520
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaM clpn hs c
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
has only substance units: false
is: CHEBI:28494
boundary condition: false
name: cardiolipin
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_a940521a_bee5_4b37_9eb9_eca22bf38618
constant: false
is encoded by: hsa:AI924226
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AI924226_1_m
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_ebcdd175_24d1_4d17_b581_f1d7f1e3f011
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:10449
constant: false
is: P42765
name: ACAA2
initial concentration: NaN
has only substance units: false

metaM dgmp e
name: dGMP(2-)
is: CHEBI:57673
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01044

metaR r0944
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
name: Active transport
fast: false
reversible: true
product: MODEL1310110044#

metaM ppi m
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species
initial concentration: 1.0
name: Diphosphate
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:33019

metaR PHEACGLNt
reversible: true
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
name: PHEACGLN extracellular transport via diffusion
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is: SBO:0000185

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM HC01434 m
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
name: oxalatosuccinate(3-)
is: CHEBI:58931

metaM phe L m
name: L-phenylalanine
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00159
is: CHEBI:17295
initial amount: NaN

metaR r0735
is: SBO:0000176
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110044#
reversible: true
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7b56b5f1_53c1_405f_8ded_9d0e9f222640
is encoded by: hsa:953
has only substance units: false
type: Species
is: Q86VV3
constant: false
boundary condition: true
initial amount: NaN
name: ENTPD1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_fe9a0ad6_a9d9_4fe4_9f68_0a59d1a3ecc0
constant: false
initial concentration: NaN
name: _NM_001929_1_c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NM 001929

metaR FACOAL181i
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110044#
is described by: ECO:0000269
product: MODEL1310110044#
reversible: false
name: C181 fatty acid activation
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_67a5647c_0327_4a9e_a098_77c02bd173fc
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: ACHE
is encoded by: hsa:43

metaM amp r
has only substance units: false
initial amount: NaN
is: C00020
boundary condition: false
is: HMDB00045
is: CHEBI:456215
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
name: AMP

metaM HC02121 c
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false
type: Species
is: CHEBI:58758
constant: false
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
boundary condition: false
initial concentration: 1.0

metaR CREATt4 2 r
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
name: Creatine transport (sodium symport) (2:1)
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false

metaR RE1254C
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
name: RE1254
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reversible: true
fast: false
is described by: ECO:0000000

metaM ppi n
boundary condition: false
is: CHEBI:33019
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: diphosphate(3-)
initial concentration: 1.0
is: HMDB00250
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_0788e559_6950_48d0_b3bb_27e41695d551
is encoded by: hsa:223
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P49189
name: ALDH9A1
has only substance units: false
type: Species
boundary condition: true

metaR CO2tp
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true
name: CO2 peroxisomal transport

metaR r0734
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110044#
type: Reaction
reversible: false
kinetic law: MODEL1310110044#

metaM ser D c
type: Species
constant: false
name: D-serine
is: HMDB03406
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM glcur e
name: D-glucuronate
is: HMDB00127
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
is: CHEBI:15748
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_5972b9b3_c6c1_4405_8381_02e7274c6b48
name: NT5C1B
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:93034
has only substance units: false
initial amount: NaN
constant: false
is: Q96P26
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_81021ddb_5e8e_4b4f_9007_02cdec206f8f
is encoded by: hsa:1609
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: P52824
name: DGKQ
constant: false
has only substance units: false

metaM his L c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:15971
constant: false
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
initial concentration: 1.0
name: L-histidine
is: HMDB00177

metaR ACACtx
product: MODEL1310110044#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110044#
name: acetoacetate intracellular transport unknown mechanism
is: SBO:0000185
reactant: MODEL1310110044#

metaR FAOXC10C8x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM gthrd m
is: CHEBI:57925
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: glutathionate(1-)
is: HMDB00125
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_24e0cb0c_82ab_47a4_aaa1_cacc83620c5e
constant: false
has only substance units: false
initial concentration: NaN
name: NME1:NME2
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110044#_a36dce72_4b6f_4a7c_8446_36bfa7198444
is encoded by: hsa:145226
constant: false
initial concentration: NaN
is: SBO:0000252
name: RDH12
is: Q96NR8
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_b4af06d7_fbfc_41a3_a2e2_511d3aa164c1
is: P00390
has only substance units: false
boundary condition: true
is encoded by: hsa:2936
name: GSR
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_45ac5d39_f757_47e9_b539_ab66aabb77fa
is: P14618
is: SBO:0000252
name: PKM2
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5315
type: Species
boundary condition: true

metaR r0733
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
modifier: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/1.5.1.12

metaM 34hpp e
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00707
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1

metaM trdox m
name: Oxidized thioredoxin
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:18191

metaM 4hglusa m
type: Species
name: L-4-hydroxyglutamic semialdehyde
initial amount: NaN
is: HMDB06556
initial concentration: 1.0
is: CHEBI:27809
has only substance units: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
constant: false
boundary condition: false
is: SBO:0000247

metaM idp e
initial concentration: 1.0
is: CHEBI:58280
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
type: Species
name: IDP(3-)
has only substance units: false
is: HMDB03335
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9e86165e_2afe_427e_b2d5_ea068772d2f0
is: P52790
constant: false
type: Species
is encoded by: hsa:3101
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: HK3
boundary condition: true

metaM atp c
is: HMDB00538
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:30616
boundary condition: false
type: Species
name: ATP(4-)
initial amount: NaN
initial concentration: 1.0
is: C00002

http://identifiers.org/biomodels.db/MODEL1310110044#_aafbeedf_1f33_44cd_83bb_5e35a6f8a064
boundary condition: true
constant: false
is: P07954
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: FH
is encoded by: hsa:2271
initial concentration: NaN

metaR GTMLTe
name: g-glutamyltransferase (e)
product: MODEL1310110044#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
reactant: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110044#
reversible: false
type: Reaction

metaM fadh2 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:58307
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
initial amount: NaN
constant: false
type: Species
is: HMDB01197
is: SBO:0000247

metaR DNDPt14m
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
name: dUDP transport via dTDP antiport
type: Reaction
kinetic law: MODEL1310110044#

metaR NDPK6n
product: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
reversible: true

metaR r0732
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR ADRNCOAtx
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: fatty acid intracellular transport
reactant: MODEL1310110044#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_656fc72d_7961_46f0_abc9_47b5b126ac5a
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9Y5B8
initial amount: NaN
name: NME7
type: Species
is encoded by: hsa:29922
is: SBO:0000252

metaM amp x
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
boundary condition: false
initial concentration: 1.0
is: CHEBI:456215
name: AMP
constant: false
type: Species
is: SBO:0000247
is: HMDB00045
has only substance units: false
initial amount: NaN

metaR PCHOLPg hs
reversible: false
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_447f1847_601c_47f1_80f0_b30afda9308c
is encoded by: hsa:3706
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: ITPKA
is: P23677
initial amount: NaN

metaM udpg r
constant: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: SBO:0000247
type: Species
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2e4631a9_9d06_471b_80d1_9b94bd49a127
initial amount: NaN
is encoded by: hsa:3707
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: P27987
name: ITPKB

metaR r1540
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
type: Reaction
reversible: false
product: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_1c308320_30cc_4822_9766_6b648ec59c4d
type: Species
is: Q53YE7
name: MAOA
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4128
has only substance units: false
initial amount: NaN
constant: false

metaM his L e
name: L-histidine
constant: false
boundary condition: false
is: CHEBI:15971
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: SBO:0000247

metaM frdp c
initial concentration: 1.0
is: SBO:0000247
name: Farnesyl diphosphate
constant: false
is: CHEBI:175763
type: Species
is: HMDB00961
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: C00448
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2d5c23bc_8e96_4704_a361_03af89e4add3
initial concentration: NaN
is: E2QC23
has only substance units: false
boundary condition: true
is encoded by: hsa:23464
name: GCAT
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM asn L e
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: HMDB00168
is: CHEBI:17196
boundary condition: false

metaR NDPK6m
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110044#
is described by: ECO:0000254
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
is: SBO:0000176
fast: false
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reversible: true

metaR r0731
reversible: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110044#
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

metaR r1978
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR RE0456M
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
fast: false
is described by: ECO:0000000
name: RE0456
type: Reaction
reversible: true

metaR SBT Dtde
type: Reaction
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
reactant: MODEL1310110044#
name: D-sorbitol transport, extracellular
is described by: ECO:0000134
reversible: true
product: MODEL1310110044#

metaM fum c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
boundary condition: false
is: CHEBI:29806
is: SBO:0000247
type: Species
is: HMDB00134

metaM 34hpp c
has only substance units: false
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00707
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate

metaR TRIODTHYt2
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
fast: false
name: T3 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e96059d3_c713_4758_b0a0_bdbbc500531f
is encoded by: hsa:122970
constant: false
name: ACOT4
type: Species
boundary condition: true
initial amount: NaN
is: Q8N9L9
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM thcholoylcoa x
initial amount: NaN
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
has only substance units: false
is: HMDB12456
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27403
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_d7a3728a_3bc7_4c3a_bb61_db6f13e32592
is encoded by: hsa:25902
is: SBO:0000252
name: MTHFD1L
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: B2RD24
constant: false
type: Species

metaR r2023
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110044#
type: Reaction
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_3f9a1e49_bf44_454d_b751_d1d924d923b5
is: SBO:0000252
boundary condition: true
name: PFAS
has only substance units: false
is: Q6P4B4
type: Species
is encoded by: hsa:5198
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_53d43120_63e5_44b2_b00e_57b078073148
is: SBO:0000252
initial amount: NaN
is: A8K7W0
type: Species
name: VNN2
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8875

metaR PNTEH
modifier: MODEL1310110044#
name: Hydrolase Class ( RXN R02973)
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false
product: MODEL1310110044#
is: SBO:0000176

metaR r0730
is version of: http://identifiers.org/ec-code/1.3.99.3
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
kinetic law: MODEL1310110044#
reversible: false
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction

metaR r1979
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_469c36e2_0ef0_4348_a874_877e781063b0
initial concentration: NaN
is: Q9H6Y6
name: MYO5B
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4645
has only substance units: false

metaR r0226
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
is: SBO:0000176
modifier: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false

metaM chlstol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: CHEBI:16290
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
is: HMDB06842
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR CITL
fast: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
name: Citrate lyase
modifier: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
is: SBO:0000176

metaM urate e
boundary condition: false
constant: false
is: C00366
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
is: CHEBI:17775
type: Species
is: SBO:0000247
name: Urate
is: HMDB00289
initial concentration: 1.0

metaR SQLEr
product: MODEL1310110044#
is described by: ECO:0000134
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.14.13.132
name: Squalene epoxidase, endoplasmic reticular (NADP)
is: SBO:0000176
fast: false

metaM phe L c
boundary condition: false
is: HMDB00159
name: L-phenylalanine
is: CHEBI:17295
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false

metaR HEXDIACTD
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM 5mthf c
boundary condition: false
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
initial amount: NaN
is: SBO:0000247
is: CHEBI:3729
is: HMDB01396
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_33e73733_0109_4dad_9fc2_2ba98f5b5a8c
type: Species
is encoded by: hsa:10166
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9Y619
name: SLC25A15

http://identifiers.org/biomodels.db/MODEL1310110044#_3ecbea50_7f3a_44b8_8b04_d38e50ec7b0e
is encoded by: hsa:60482
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9GZV3
boundary condition: true
initial amount: NaN
name: SLC5A7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c96fc7bf_3b2a_44b3_afbb_11fa901622e4
initial amount: NaN
boundary condition: true
type: Species
name: PANK2
is encoded by: hsa:80025
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7256d77c_b703_48a2_9e03_ff553c23316b
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6581
initial concentration: NaN
is: SBO:0000252
is: Q5SYN6
name: SLC22A3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_dc2fd48a_c1f1_49fb_a96d_3cfea792c51f
boundary condition: true
initial amount: NaN
type: Species
name: ALAS1
constant: false
has only substance units: false
is: P13196
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:211

metaM utp m
is: HMDB00285
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: UTP(4-)
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
constant: false
is: CHEBI:46398
boundary condition: false

metaM 4abut m
has only substance units: false
initial amount: NaN
is: CHEBI:16865
constant: false
is: SBO:0000247
is: C00334
initial concentration: 1.0
name: 4-Aminobutanoate
is: HMDB00112
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
boundary condition: false

metaM dcyt n
initial concentration: 1.0
is: CHEBI:15698
name: 2'-deoxycytidine
is: HMDB00014
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fc01635e_9f80_4afe_bec6_94d91ee40fb7
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:762
initial amount: NaN
is: Q6FHI7
initial concentration: NaN
has only substance units: false
name: CA4

http://identifiers.org/biomodels.db/MODEL1310110044#_35dd389c_d217_4ff3_9c19_726778885c9e
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AI694761
constant: false
initial concentration: NaN
type: Species
name: _AI694761_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_463bfc26_9ed1_481e_b4a0_09b72440b597
name: PDE8A
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5151
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR r0517
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
reactant: MODEL1310110044#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7b874ce0_fe4b_4f59_a0ee_1edb32fe7ec4
name: AMT
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:275
is: P48728
constant: false
boundary condition: true
initial amount: NaN

metaR r1973
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110044#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM malthp e
type: Species
constant: false
is: C01936
name: maltoheptaose
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: SBO:0000247
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
initial concentration: 1.0
has only substance units: false

metaM utp n
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
initial amount: NaN
name: UTP(4-)
is: CHEBI:46398
has only substance units: false
is: HMDB00285
is: SBO:0000247
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_eeeb5b90_5b2e_4feb_a96c_399016044a6a
is encoded by: hsa:11332
has only substance units: false
name: ACOT7
initial amount: NaN
is: O00154
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_a9d61b63_baaf_41cf_b3a4_22e093868e41
constant: false
name: UPP2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:151531
is: O95045
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_1ffcf169_817b_41e3_aa42_0d08376ad2b7
initial concentration: NaN
is: P11926
type: Species
initial amount: NaN
is encoded by: hsa:4953
has only substance units: false
is: SBO:0000252
name: ODC1
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_374dd55b_a1e5_48f9_9186_3b4d7b80e601
is encoded by: hsa:2686
type: Species
is: SBO:0000252
name: GGT7
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: A0PJJ9

metaR FAOXC121x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM lnlncgcoa r
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
is: SBO:0000247
constant: false
initial amount: NaN

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110044#
name: inositol-1,4,5-trisphosphate 5-phosphatase
is: SBO:0000176
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56

metaR RE3001M
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.34
name: RE3001
reversible: true
type: Reaction

metaM fum m
name: Fumarate
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: HMDB00134
initial concentration: 1.0
boundary condition: false
is: CHEBI:29806
initial amount: NaN
constant: false
is: C00122

http://identifiers.org/biomodels.db/MODEL1310110044#_c59687d2_18f5_4f98_973b_78975f54d83c
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AL050025
initial concentration: NaN
name: _AL050025_1_c

http://identifiers.org/biomodels.db/MODEL1310110044#_428822d0_63df_4f40_859c_f09dded81c55
constant: false
is: P28330
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ACADL
is: SBO:0000252
is encoded by: hsa:33
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_d7fc5a40_c2fd_4031_92f1_320798c83d48
is encoded by: hsa:1375
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: CPT1B
has only substance units: false
is: B7Z5T8
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_43c96527_8f09_418b_9cba_655294ecf6ee
name: SLC2A8
initial amount: NaN
is: SBO:0000252
is: Q9NY64
has only substance units: false
is encoded by: hsa:29988
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR ALAGLYexR
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110044#
name: L-alanine/glycine reversible exchange
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000304
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110044#

metaM 5mthf e
initial amount: NaN
boundary condition: false
is: C00440
is: SBO:0000247
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: HMDB01396
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: 5-Methyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110044#_e89c190c_292a_4d45_bf1c_154ff85d0014
type: Species
has only substance units: false
is: P61457
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5092
name: PCBD1

metaM phe L e
has only substance units: false
boundary condition: false
is: HMDB00159
is: CHEBI:17295
initial amount: NaN
constant: false
name: L-phenylalanine
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

metaM atp e
is: SBO:0000247
is: C00002
boundary condition: false
name: ATP(4-)
has only substance units: false
is: HMDB00538
initial amount: NaN
type: Species
is: CHEBI:57299
constant: false
initial concentration: 1.0

metaM dgsn c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
is: CHEBI:17172
is: SBO:0000247
name: Deoxyguanosine
is: C00330
constant: false
is: HMDB00085
boundary condition: false

metaR r0839
is version of: http://identifiers.org/ec-code/1.3.1.70
name: Postulated transport reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185

metaR FUMm
name: fumarase, mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000134
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
type: Reaction
modifier: MODEL1310110044#

metaM ddsmsterol r
initial concentration: 1.0
name: 7-dehydrodesmosterol
constant: false
is: HMDB03896
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:27910
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
has only substance units: false
initial amount: NaN

metaR L LACt4r
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
name: L-lactate reversible transport via sodium symport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_b007db64_6002_4d78_90a3_be5b3f459e73
initial concentration: NaN
constant: false
has only substance units: false
name: _728226_1_m
initial amount: NaN
type: Species
is encoded by: hsa:728226
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_c74a8ba8_7030_4c2a_aab8_f79d66a679a2
has only substance units: false
initial amount: NaN
name: LHPP
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q9H008
constant: false
is encoded by: hsa:64077

metaM c14dccoa x
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: tetradecanedioylcoa
boundary condition: false
is: HMDB02288
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
initial concentration: 1.0
initial amount: NaN

metaM nmn n
name: NMN(-)
initial concentration: 1.0
has only substance units: false
is: HMDB00229
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
type: Species
is: CHEBI:14649

http://identifiers.org/biomodels.db/MODEL1310110044#_08b29411_f320_415c_a3a8_dfe820b4f149
name: ACAD8
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q6ZWP6
is encoded by: hsa:27034
initial amount: NaN
is: SBO:0000252
type: Species

metaR r1975
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CHATn
reactant: MODEL1310110044#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
name: Choline O-acetyltransferase
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_f018fbf0_6b2e_4467_b522_71ec2a78c776
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI934540
boundary condition: true
name: _AI934540_1_c
is: SBO:0000252

metaM HC02020 r
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Cholesterol-ester-palm
is: SBO:0000247
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
initial amount: NaN
constant: false
type: Species
is: CHEBI:3663

metaM pect e
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2535H3509O2535 CHARGE: -1
initial amount: NaN
is: SBO:0000247
is: HMDB03402
has only substance units: false
type: Species
name: pectins

metaR LEUKTRA4t
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
name: leukotriene A4 transport
kinetic law: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_d952074f_0fd4_4db9_8eff_3da86cdf4390
is encoded by: hsa:11112
initial amount: NaN
is: P31937
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: HIBADH
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_36f2f83d_4544_4528_90db_9ec2741d5f35
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q5MY95
boundary condition: true
type: Species
initial concentration: NaN
name: ENTPD8
is encoded by: hsa:377841
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_37c2d377_f32b_4252_9be7_16eef8e4b264
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:7296
is: SBO:0000252
name: TXNRD1
initial amount: NaN

metaM met L c
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00696
is: CHEBI:16643
constant: false
boundary condition: false
name: L-methionine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

metaR LNSTLSr
reversible: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.99.7
modifier: MODEL1310110044#
name: lanosterol synthase

metaR r0512
modifier: MODEL1310110044#
is: SBO:0000176
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reactant: MODEL1310110044#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_adffb2d6_9c9c_4650_bbaf_e6e2debfdf45
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: ABCA1
is encoded by: hsa:19
initial amount: NaN
is: O95477

metaR D LACt2
kinetic law: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
reversible: true
fast: false
name: D-lactate transport via proton symport
product: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110044#_4599a23f_cf49_472c_a5ef_c0d16a08f114
type: Species
initial amount: NaN
has only substance units: false
is: P15328
is: SBO:0000252
is encoded by: hsa:2348
boundary condition: true
name: FOLR1
constant: false
initial concentration: NaN

metaM gthrd e
name: glutathionate(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57925
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false

metaR r2510
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110044#

metaR FAOXC164C143m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM cgly c
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
is: HMDB00078
constant: false
boundary condition: false
is: CHEBI:4047
type: Species
initial amount: NaN
is: SBO:0000247
name: L-cysteinylglycine

metaR 4MOPt2im
reversible: false
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false

metaR CYTD
reactant: MODEL1310110044#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
is: SBO:0000176
name: cytidine deaminase
modifier: MODEL1310110044#
type: Reaction
reversible: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
kinetic law: MODEL1310110044#

metaM hyptaur c
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial amount: NaN
is: CHEBI:16668
constant: false
has only substance units: false
name: Hypotaurine
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00965
boundary condition: false

metaM HC00695 m
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:17432
initial concentration: 1.0
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
name: S-Succinyldihydrolipoamide
constant: false
boundary condition: false

metaM for e
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15740
initial concentration: 1.0
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
constant: false
name: formate
boundary condition: false

metaR r2131
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
is: SBO:0000185

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM nadp c
is: SBO:0000247
is: C00006
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate

metaR r1824
reversible: false
product: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_a36055fd_ffe3_423f_b5af_ee0bd44b00a0
initial amount: NaN
is: SBO:0000252
is: O95954
is encoded by: hsa:10841
name: FTCD
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaM idp n
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
type: Species
initial concentration: 1.0
is: HMDB03335
has only substance units: false
name: IDP(3-)
constant: false

metaM etoh e
is: SBO:0000247
has only substance units: false
is: CHEBI:16236
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00108
name: ethanol
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469

http://identifiers.org/biomodels.db/MODEL1310110044#_bb1b5288_f159_4094_bec5_b73b93ebbc31
type: Species
is encoded by: hsa:BC005314
has only substance units: false
initial concentration: NaN
name: _BC005314_1_x
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM nadh c
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
is: HMDB01487
is: C00004
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaR r2511
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Utilized transport
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7194d809_d5d9_49ee_b04c_7a873cfba70a
type: Species
is encoded by: hsa:80025
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q6P1K9
constant: false
initial concentration: NaN
initial amount: NaN
name: PANK2

metaR r0838
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
product: MODEL1310110044#
type: Reaction
fast: false
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#

metaR r0670
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110044#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000176
reversible: false

metaR r2130
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_fb753f52_d7e8_4190_9816_c4c2b1f546df
is encoded by: hsa:9187
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: SLC24A1
is: SBO:0000252
boundary condition: true
is: B4DUG1

metaR ITPtn
product: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
name: ITP nuclear transport

metaM xol27oh m
constant: false
is: CHEBI:17703
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
name: 26-hydroxycholesterol

metaM adrncoa x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
is: C16170
initial concentration: 1.0
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaM met L e
is: CHEBI:16643
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00696
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
constant: false
name: L-methionine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_0922dcea_459d_4a94_b844_501254ff5ef8
type: Species
is encoded by: hsa:1103
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q6LEN6
name: CHAT
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7cf5f6ca_dd92_49a3_9ab3_cf16a39fe133
boundary condition: true
type: Species
is: SBO:0000252
is: P23921
has only substance units: false
initial amount: NaN
is encoded by: hsa:6240
constant: false
name: RRM1
initial concentration: NaN

metaM gthrd c
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Reduced glutathione
constant: false
is: CHEBI:57925
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: C00051
is: HMDB00125
boundary condition: false

metaR RE1845C
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false

metaR G6PDA
modifier: MODEL1310110044#
name: glucosamine-6-phosphate deaminase
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
reactant: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.99.6
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM urate c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: Urate
boundary condition: false
is: CHEBI:17775
is: HMDB00289
has only substance units: false
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaR r0835
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaM cgly e
name: L-cysteinylglycine
is: HMDB00078
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
boundary condition: false
is: CHEBI:4047
initial amount: NaN
is: SBO:0000247
type: Species

metaM thf m
name: 5,6,7,8-Tetrahydrofolate
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: C00101
is: SBO:0000247
is: HMDB01846
is: CHEBI:57453

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB06469
is: SBO:0000247
boundary condition: false
name: Linoleyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110044#_03f6bcfa_71f2_4ee9_8092_302fcbd7d771
is encoded by: hsa:3295
boundary condition: true
name: HSD17B4
has only substance units: false
is: E9PB82
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_a67e865b_2772_4292_886f_0bb40370a66f
constant: false
initial amount: NaN
name: EHHADH
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1962
type: Species
boundary condition: true
initial concentration: NaN
is: Q9NY65

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_11e15f17_16be_448d_9128_0392af9a3669
is: P56556
has only substance units: false
constant: false
is encoded by: hsa:4700
name: NDUFA6
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM doco13ecoa x
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892791
name: 13-docosenoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_8af0c607_09e5_416e_9fb8_616e9933130a
has only substance units: false
name: SLC25A2
is: Q9BXI2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:83884
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR r1291
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110044#
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false

metaM for c
is: HMDB00142
constant: false
boundary condition: false
name: Formate
initial concentration: 1.0
has only substance units: false
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
type: Species
is: CHEBI:15740
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_31a3850b_fc6d_4a9d_ac3c_f438fe60d2ea
name: NT5C
initial amount: NaN
is encoded by: hsa:30833
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: Q8TCD5
is: SBO:0000252
has only substance units: false

metaM leuktrE4 c
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB02200
name: leukotriene E4(1-)
is: CHEBI:57462
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

metaR r0009
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110044#
reversible: false
is: SBO:0000176
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton

metaM sql r
initial concentration: 1.0
is: HMDB00256
initial amount: NaN
is: CHEBI:15440
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
name: squalene
boundary condition: false

metaR FAOXC12C10x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaM HC02179 c
initial concentration: 1.0
is: CHEBI:34306
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
has only substance units: false
name: 20-hydroxy-arachidonate

metaM C05965 e
has only substance units: false
name: 12(S)-HPETE(1-)
initial amount: NaN
is: HMDB04243
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial concentration: 1.0
boundary condition: false
is: CHEBI:57444
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_9800374d_d5a1_481f_b3ad_92d06719413a
has only substance units: false
is encoded by: hsa:50
is: SBO:0000252
name: ACO2
initial concentration: NaN
boundary condition: true
type: Species
is: Q99798
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_cf09deb1_8546_4eb4_ae61_da1f1b84eea2
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PANK1
initial amount: NaN
constant: false
is encoded by: hsa:53354
initial concentration: NaN

metaM ppi r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
is: HMDB00250
name: Diphosphate
is: SBO:0000247
has only substance units: false

metaM 4abut n
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: HMDB00112
initial amount: NaN
has only substance units: false
name: 4-Aminobutanoate
initial concentration: 1.0

metaR r0672
reactant: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_f4a5da3c_a4eb_4ccd_95c4_ae808d1c5183
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:956
type: Species
constant: false
is: O75355
name: ENTPD3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_469ae5d3_d235_4e28_8629_6e5d6c4d24a1
name: NME6
initial amount: NaN
is encoded by: hsa:10201
type: Species
is: O75414
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0836
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR RE2079R
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
name: RE2079

metaR RE2814R
fast: false
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: true

metaM k e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:29103
constant: false
name: potassium
type: Species
has only substance units: false
is: HMDB00586
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_32ff57ba_28dd_4ad3_99e0_6d961a195d43
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false
name: HK1
constant: false
type: Species
is: A8K7J7

metaR AMETr
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
name: S-Adenosyl-L-methionine intracellular diffusion
is: SBO:0000185

metaR GLYCTDle
reactant: MODEL1310110044#
reversible: true
product: MODEL1310110044#
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR CYTK6n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
name: cytidylate kinase (CMP,CTP),nuclear

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7040e758_63e7_474b_ab1e_ed05cc465fe7
is: P54868
has only substance units: false
constant: false
is encoded by: hsa:3158
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: HMGCS2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_8f0f18a2_b822_4137_8cba_2d83f2e68d48
name: _H17063_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:H17063
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaM retinol e
is: SBO:0000247
is: HMDB00305
is: CHEBI:50211
name: retinol
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_50f7b312_bad5_45af_9414_f81a82041c20
is encoded by: hsa:U37519
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: _U37519_1_e
constant: false
has only substance units: false
is: SBO:0000252

metaR DALAt2r
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000304
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
type: Reaction
name: D-alanine transport via proton symport
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_ec48802a_8174_43f8_8417_8b6693a4d6eb
initial amount: NaN
constant: false
is: Q8WZ48
name: CPT1A
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:1374
is: SBO:0000252

metaR r1615
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110044#
reversible: true
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_fb421676_4722_4e43_9905_5780480bcc8d
name: HK1
constant: false
is encoded by: hsa:3098
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P19367
initial amount: NaN

metaM amp c
constant: false
is: HMDB00045
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP
is: CHEBI:3322
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b0a42dfe_b536_473a_8fc1_45087d98e22d
type: Species
initial concentration: NaN
is: SBO:0000252
name: PLCB4
has only substance units: false
is: Q15147
is encoded by: hsa:5332
initial amount: NaN
boundary condition: true
constant: false

metaM HC00718 c
is: CHEBI:57781
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: N-methylethanolaminium phosphate(1-)
is: SBO:0000247

metaM lac D e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
is: SBO:0000247
is: HMDB01311
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: (R)-lactate
is: CHEBI:16004
has only substance units: false
type: Species

metaM HC01399 m
has only substance units: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
is: CHEBI:27466
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false

metaR 5MTAte
kinetic law: MODEL1310110044#
reversible: true
fast: false
type: Reaction
name: Transport of 5-S-methyl-5-thioadenosine
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_6206cb65_f2c3_48e7_8745_b272e0788719
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:54539
initial concentration: NaN
is: Q9NX14
name: NDUFB11
initial amount: NaN
constant: false

metaM rib D c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16988
name: D-ribose
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283

http://identifiers.org/biomodels.db/MODEL1310110044#_4ba54d3f_9a13_48a4_bd45_9db79acde0f4
is encoded by: hsa:377677
is: Q8N1Q1
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: CA13
boundary condition: true

metaR NCKt
kinetic law: MODEL1310110044#
reversible: true
name: Na+/Ca2+-K+ exchange
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110044#
is described by: ECO:0000269
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#

metaM 4abut e
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
is: C00334
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:3628
name: 4-Aminobutanoate
initial concentration: 1.0
is: HMDB00112

metaM udpglcur c
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
is: C00167
name: UDP-D-glucuronate
boundary condition: false
constant: false
is: CHEBI:58052
has only substance units: false
is: HMDB00935
initial amount: NaN
type: Species
is: SBO:0000247

metaM nadh x
boundary condition: false
type: Species
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
initial amount: NaN
has only substance units: false
is: HMDB01487
is: SBO:0000247
is: C00004
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0

metaR HACD9m
is described by: ECO:0000134
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_d5bc4ce2_5bf8_4a9a_bfee_12ebbe2d06bd
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3990
is: A6H8L5
name: LIPC
initial concentration: NaN

metaM fru c
is: HMDB00660
name: D-Fructose
is: CHEBI:15824
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
boundary condition: false
is: C00095
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_cfb7d618_2dc4_4f4c_b408_5ea787825a4f
name: NSDHL
initial concentration: NaN
type: Species
boundary condition: true
is: Q15738
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:50814
has only substance units: false

metaR r1616
reactant: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

metaM 6thf e
constant: false
is: http://identifiers.org/pubchem.compound/169691
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
type: Species
has only substance units: false
boundary condition: false
name: hexaglutamyl folate (THF)

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_fcfc5e9b_819f_4527_a8ae_eaa067250906
initial amount: NaN
constant: false
name: SLC26A11
is: Q86WA9
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:284129
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_b8b7b578_9b13_4fbf_93da_25beefcf961d
is: SBO:0000252
is: Q5MY95
initial amount: NaN
boundary condition: true
is encoded by: hsa:377841
initial concentration: NaN
has only substance units: false
type: Species
name: ENTPD8
constant: false

metaM air c
boundary condition: false
is: C03373
initial amount: NaN
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
is: SBO:0000247
is: CHEBI:58592
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species
is: HMDB01235
initial concentration: 1.0
constant: false
has only substance units: false

metaM utp e
name: UTP(4-)
initial amount: NaN
type: Species
is: HMDB00285
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
is: CHEBI:46398
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR BDHm
reversible: true
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.30
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#

metaR HACD1m
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
fast: false
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological

metaM atp m
is: C00002
constant: false
is: HMDB00538
type: Species
initial concentration: 1.0
is: CHEBI:57299
name: ATP(4-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM 34dhoxmand m
initial amount: NaN
is: HMDB01866
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:27637
has only substance units: false
is: SBO:0000247

metaR r2132
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110044#_454e846d_ebcf_450a_a282_d0f7ceba723d
initial amount: NaN
name: PLCD1
constant: false
is encoded by: hsa:5333
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: P51178

http://identifiers.org/biomodels.db/MODEL1310110044#_6ca08ca4_d8c6_40e1_9bd9_2345833b9ead
is encoded by: hsa:1716
name: DGUOK
initial amount: NaN
is: E5KSL6
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaM k c
is: C00238
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:29103
is: SBO:0000247
name: potassium
has only substance units: false
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
is: HMDB00586

metaM dnad c
is: CHEBI:18304
has only substance units: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: SBO:0000247
is: HMDB01179
initial concentration: 1.0
initial amount: NaN
name: Deamino-NAD+
type: Species
is: C00857
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_29239666_f2a8_461a_bec8_d6fd680079f3
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SGPP1
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q9BX95
is encoded by: hsa:81537

metaR ADK3m
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
type: Reaction
name: adentylate kinase (GTP)
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#

metaM oxa m
type: Species
boundary condition: false
constant: false
name: oxalate(2-)
is: HMDB02329
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30623
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR GUAPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
reversible: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000176
name: guanine phosphoribosyltransferase

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR ALAt4
is described by: ECO:0000269
name: Alanine-Sodium symporter
type: Reaction
reversible: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.

http://identifiers.org/biomodels.db/MODEL1310110044#_d811e297_2c61_474c_840b_dfe1c309b5df
initial amount: NaN
has only substance units: false
name: UROC1
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q68CJ7
boundary condition: true
is encoded by: hsa:131669
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_3b67bb97_ad9e_46eb_a940_0ec410a2ebf7
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PLCB4
constant: false
is: SBO:0000252
is: E2QRH8
type: Species
is encoded by: hsa:5332

http://identifiers.org/biomodels.db/MODEL1310110044#_622f365f_a157_4444_9c63_0b435c7d1d33
constant: false
initial concentration: NaN
name: HADHA
initial amount: NaN
is: E9KL44
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3030
type: Species

metaR 3MOPte
is described by: ECO:0000134
product: MODEL1310110044#
name: Transport of 3-methyl-2-oxopentanoate
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM etoh c
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00108
boundary condition: false
is: SBO:0000247
name: ethanol
is: CHEBI:16236
has only substance units: false
type: Species

metaR r1613
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110044#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000

metaR URIK1
is described by: ECO:0000269
reactant: MODEL1310110044#
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
name: uridine kinase (ATP:Uridine)
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_498c1b9b_3be8_410b_bb2b_4fc38e32d893
name: SLC26A8
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:116369
type: Species

metaR RDH1
name: retinol dehydrogenase (all-trans)
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaM frdp x
is: HMDB00961
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:175763
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
name: farnesyl pyrophosphate(3-)

metaM lac D c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (R)-lactate
is: HMDB01311
is: CHEBI:16004
initial amount: NaN
has only substance units: false
type: Species

metaR r2133
kinetic law: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_1af44c3a_916d_4f7a_8b82_c11480a56031
type: Species
is encoded by: hsa:1340
name: COX6B1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P14854

http://identifiers.org/biomodels.db/MODEL1310110044#_95da7a9f_a8cb_4563_94db_70c34c111957
boundary condition: true
is encoded by: hsa:51268
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: Q9P0Z9
name: PIPOX

metaR RE1522M
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reactant: MODEL1310110044#
name: RE1522
modifier: MODEL1310110044#
reversible: true
type: Reaction
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM atp n
is: CHEBI:57299
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
constant: false
is: HMDB00538
type: Species
has only substance units: false
boundary condition: false
name: ATP(3-)
is: SBO:0000247
initial amount: NaN

metaR FAOXC61C4m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR r0386
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaM trdox c
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: C00343
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Oxidized thioredoxin

metaM adrncoa c
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
name: adrenyl coenzyme A
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a350bf2a_9fdb_4433_bfe8_cd4a79143da0
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _T83654_1_e
type: Species
is encoded by: hsa:T83654
constant: false
is: SBO:0000252
initial amount: NaN

metaR AHCYStr
is described by: ECO:0000000
product: MODEL1310110044#
name: S-Adenosyl-L-homocysteine intracellular diffusion
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110044#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_b477d790_4fe0_469c_b65a_b43411efc0e0
initial concentration: NaN
is encoded by: hsa:6584
type: Species
initial amount: NaN
is: O76082
name: SLC22A5
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM crn m
is: CHEBI:16347
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
name: L-Carnitine
type: Species
is: C00318
is: HMDB00062
initial amount: NaN

metaR NAHCO3 HCLt
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110044#
is described by: ECO:0000269
reactant: MODEL1310110044#
fast: false
name: bicarbonate transport (HCl/NaHCO3 exchange)
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e7b88a50_a601_4d42_a452_a9022e319b74
name: GCDH
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2639
constant: false
boundary condition: true

metaR URAt
kinetic law: MODEL1310110044#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: uracil transport via facilated diffusion
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_6c37539e_7ac4_468b_896a_24e8fa76325a
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PPA2
constant: false
has only substance units: false
is encoded by: hsa:27068
type: Species
initial concentration: NaN

metaM 4abut c
is: HMDB00112
is: SBO:0000247
name: 4-Aminobutanoate
is: C00334
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:3628
has only substance units: false
type: Species

metaR r1614
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR GLCGLUT2
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
name: Transport of glucose into the portal blood
fast: false
is described by: ECO:0000134
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 71-74 NOTES:GLUT-2 can also move to the apical surface and aid in glucose import into the cell under fully fed state (PMID: 17786952)

metaR RE1519M
reactant: MODEL1310110044#
reversible: true
name: RE1519
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110044#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7ac26088_148e_4f62_a864_5ea6669817fd
constant: false
type: Species
name: PRPS1L1
is encoded by: hsa:221823
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P21108

metaR DAGt
name: diacylglycerol transport
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaM CE5120 m
name: trans-2-cis-8-tetradecadienoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
constant: false
is: CHEBI:57923
has only substance units: false

metaM 4hphac c
is: SBO:0000247
type: Species
name: 4-hydroxyphenylacetate
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false
is: CHEBI:48999
constant: false
has only substance units: false
is: HMDB00020
initial amount: NaN
initial concentration: 1.0

metaR NH4tp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
name: ammonia peroxisomal transport

metaR r1298
product: MODEL1310110044#
fast: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#

metaR ASPPROASCT1
is described by: ECO:0000134
name: aspartate intake by system ASCT-1 transporter
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
reversible: false
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
product: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_aaf2c0fa_1ad0_478f_8956_cededb01ea9c
has part: Q92569
initial amount: NaN
type: Species
is encoded by: hsa:8503
boundary condition: true
is: SBO:0000297
has part: A7E2E0
has only substance units: false
initial concentration: NaN
name: PIK3CD:PIK3R3
constant: false
is encoded by: hsa:5293

metaM dttp c
type: Species
is: CHEBI:37568
name: dTTP
constant: false
initial concentration: 1.0
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_04beeb82_eff8_467b_9c9a_924cceac5631
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: SLC24A4
is: Q8NFF2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:123041
boundary condition: true

metaR r0308
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:

metaR r1619
reversible: true
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false

metaM 3mob m
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
boundary condition: false
is: HMDB00019
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_f65fee13_5ee6_4fb4_85a6_dd0a84edd060
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: RFK
is encoded by: hsa:55312
constant: false
boundary condition: true
is: B2RDZ2
initial concentration: NaN

metaR r0666
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
product: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2

metaM Rtotalcoa c
is: HMDB00904
constant: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
type: Species
name: R total Coenzyme A
is: SBO:0000247
is: CHEBI:16349
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_3617b5f9_9f6e_4f6b_90c0_82df54b9b6f6
is encoded by: hsa:AL525798
has only substance units: false
boundary condition: true
name: _AL525798_1_c
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b89d5375_cc84_4d72_941f_3a07965ec2d0
is: P27338
initial amount: NaN
name: MAOB
type: Species
has only substance units: false
is encoded by: hsa:4129
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

metaM frdp r
is: CHEBI:175763
constant: false
type: Species
initial amount: NaN
name: Farnesyl diphosphate
has only substance units: false
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: C00448
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM pi e
initial amount: NaN
is: HMDB00973
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: hydrogenphosphate
is: CHEBI:43474
is: C00009
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

http://identifiers.org/biomodels.db/MODEL1310110044#_d325f844_f59a_4027_8f39_3e2e1068daa6
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q14642
type: Species
is encoded by: hsa:3632
is: SBO:0000252
name: INPP5A

metaR r2507
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#

metaM HC00250 c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
type: Species
is: CHEBI:29919
name: hydrosulfide
has only substance units: false
constant: false
is: SBO:0000247

metaM hom L c
has only substance units: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:15699
is: SBO:0000247
type: Species
is: HMDB00719
name: L-homoserine

metaM adn c
has only substance units: false
is: CHEBI:16335
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
constant: false
type: Species
name: Adenosine
is: C00212

http://identifiers.org/biomodels.db/MODEL1310110044#_e561ca52_9cf9_4e21_bde0_a7200a31932b
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q9Y233
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10846
name: PDE10A

http://identifiers.org/biomodels.db/MODEL1310110044#_f87931f4_d31a_4dec_95d8_0f8d328c2b45
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ALDOB
is encoded by: hsa:229
type: Species
initial amount: NaN
is: P05062
has only substance units: false
constant: false

metaM HC01412 m
constant: false
name: trans-tetradec-2-enoyl-CoA(4-)
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
type: Species
initial concentration: 1.0
is: CHEBI:61405
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_00262326_fbf7_4439_aa8e_b8105acef583
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: D3DWC4
is encoded by: hsa:259230
name: SGMS1
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaM uri m
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
has only substance units: false
name: uridine
is: SBO:0000247
constant: false
is: CHEBI:16704
type: Species
is: HMDB00296
initial amount: NaN
boundary condition: false

metaM lnlccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
type: Species
is: HMDB06469
has only substance units: false
name: Linoleyl carnitine
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaR TALA
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
name: transaldolase
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.2.1.2

metaR RE2814M
is described by: ECO:0000000
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
fast: false
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176

metaR 34DHPLACOX
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
reversible: false
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
is described by: ECO:0000269
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR RE2999M
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2999
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#

metaM 4hphac e
boundary condition: false
initial concentration: 1.0
name: 4-hydroxyphenylacetate
type: Species
has only substance units: false
is: HMDB00020
is: CHEBI:48999
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642

http://identifiers.org/biomodels.db/MODEL1310110044#_7dff3f03_d07a_427c_9e4c_d1946c0fe9b5
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: _AI378339_1_m
has only substance units: false
is encoded by: hsa:AI378339
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_2f591eb5_b7ce_4500_b9c2_46157f156c7a
boundary condition: true
initial concentration: NaN
is: Q7LG56
is: SBO:0000252
name: RRM2B
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:50484

metaR r2506
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
product: MODEL1310110044#

metaR FAOXC226m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM fol e
name: Folate
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
is: HMDB00121
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ecd91cf6_296d_4391_a8d6_23238c6849bb
type: Species
is encoded by: hsa:6509
constant: false
is: P43007
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC1A4
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_725049db_20e6_4331_b2e7_a90cba2658f2
constant: false
name: CDO1
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: Q16878
is encoded by: hsa:1036
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b4cd8010_ddfd_42a1_9bde_2b69d7367cb2
initial concentration: NaN
is encoded by: hsa:115019
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: B3KXK1
name: SLC26A9
is: SBO:0000252
boundary condition: true

metaM accoa x
type: Species
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
has only substance units: false
constant: false
is: C00024
is: CHEBI:57288
name: Acetyl-CoA
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM retinol c
initial amount: NaN
is: HMDB00305
boundary condition: false
name: retinol
has only substance units: false
is: CHEBI:50211
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247

metaM dttp e
type: Species
name: dTTP(4-)
is: CHEBI:37568
is: HMDB01342
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
constant: false

metaR LNLCCRNt
reactant: MODEL1310110044#
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
type: Reaction
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110044#

metaR r2136
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_c0144a97_c270_43fd_a2ae_c87c87c3de60
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:349565
name: NMNAT3
has only substance units: false
initial concentration: NaN
is: Q96T66
initial amount: NaN
constant: false

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_692440e7_ff74_42e7_b3d6_5d56a96bf74a
is: Q15067
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ACOX1
is encoded by: hsa:51
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_d06085e3_b787_493c_a000_44228ac7bb70
constant: false
is: SBO:0000252
name: SLC2A3
has only substance units: false
is: P11169
initial amount: NaN
type: Species
is encoded by: hsa:6515
initial concentration: NaN
boundary condition: true

metaR ALADGLNexR
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange

metaR r0668
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.19
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
fast: false

metaR r1617
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false

metaM q10 m
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
name: ubiquinone-10
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01072

metaM HC00250 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
type: Species
is: CHEBI:29919
boundary condition: false
constant: false
name: hydrosulfide
is: SBO:0000247
has only substance units: false

metaR NH4tn
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
product: MODEL1310110044#
fast: false
reversible: true
reactant: MODEL1310110044#
is: SBO:0000185
name: ammonia nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110044#_cbc4b04b_c91e_4012_9bf9_724e48c47007
boundary condition: true
is: Q16881
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: TXNRD1
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:7296

metaR URATEt
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is: SBO:0000185
reversible: false
name: urate export from cytosol
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM xan c
type: Species
is: CHEBI:17712
is: HMDB00292
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
boundary condition: false
name: Xanthine
is: C00385
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_ecf9105f_20ea_4661_bb63_594c760c247c
constant: false
is: P00568
is encoded by: hsa:203
boundary condition: true
name: AK1
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a32fc983_0337_4cd8_a53f_dd232a4235c3
is encoded by: hsa:160287
has only substance units: false
constant: false
is: Q6ZMR3
name: LDHAL6A
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaM adn e
name: Adenosine
is: SBO:0000247
is: CHEBI:16335
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
is: HMDB00050
type: Species
is: C00212

metaR r1299
is: SBO:0000185
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
fast: false
is described by: ECO:0000000

metaM hdd2coa x
constant: false
is: CHEBI:61526
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB03945
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
name: (E)-hexadec-2-enoyl-CoA(4-)

metaR NADtx
product: MODEL1310110044#
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: true
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of NAD into peroxisome
kinetic law: MODEL1310110044#

metaM amp e
is: HMDB00045
name: AMP
is: CHEBI:456215
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00020

metaR NICRNS
fast: false
kinetic law: MODEL1310110044#
name: NICRNS
is: SBO:0000176
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_d90e3698_a56e_42b6_bade_bca8d04d6b76
type: Species
is encoded by: hsa:766
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q86YU0
initial amount: NaN
name: CA7
constant: false
initial concentration: NaN

metaM rib D e
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
initial amount: NaN
name: D-ribose
is: HMDB00283
is: CHEBI:16988
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false

metaM atp r
name: ATP(4-)
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57299
is: C00002
is: HMDB00538

metaM 2dr1p c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial concentration: 1.0
name: 2-Deoxy-D-ribose 1-phosphate
is: C00672
constant: false
type: Species
boundary condition: false
is: CHEBI:58576
has only substance units: false
is: HMDB01351

metaR DGK1
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110044#
name: deoxyguanylate kinase (dGMP:ATP)
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000269

metaR MI145PK
is described by: ECO:0000269
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.127
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reversible: false
product: MODEL1310110044#
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
name: inositol-1,4,5-trisphosphate 3-kinase

metaR r1618
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
modifier: MODEL1310110044#

metaM utp c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00075
initial amount: NaN
name: UTP
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
type: Species
is: HMDB00285
constant: false

metaR r2137
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_6eaf3a78_71da_4250_8176_8e00e550a764
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:222
is: P48448
name: ALDH3B2

metaR RE2974C
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.68
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.149
modifier: MODEL1310110044#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110044#

metaM fol c
name: Folate
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00121
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_1c4c49c9_ec13_4527_a93d_1e6a97bd33f9
is: SBO:0000252
type: Species
is: A8K0I1
boundary condition: true
is encoded by: hsa:160851
name: DGKH
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR r0236
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: true
type: Reaction

metaR FATP3t
modifier: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000269
name: fatty acid electroneutral transport
reversible: true
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110044#_d4bdccb6_a375_450e_b6a1_48da0657b3ad
initial amount: NaN
is: P04035
name: HMGCR
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3156
constant: false
initial concentration: NaN

metaR GLYCt
type: Reaction
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
reversible: true
name: glycerol transport via channel
kinetic law: MODEL1310110044#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_60f14ea9_44c7_4543_ae95_fdbf9657a1b2
is: Q16720
has only substance units: false
type: Species
is encoded by: hsa:492
name: ATP2B3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM tetde5coa x
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
type: Species
is: C05280
initial concentration: 1.0
constant: false
name: 5-tetradecenoylcoa
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB03952
has only substance units: false

metaM thym c
initial amount: NaN
name: Thymine
is: CHEBI:17821
has only substance units: false
constant: false
is: HMDB00262
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: C00178
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_94b53602_d68b_4f2b_a1bd_4ed6535b4ea8
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110044#_2e85384d_7464_40fa_9ad8_281f61d0c1ff
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:3033
name: HADH
boundary condition: true
is: Q16836
type: Species

metaM oxa c
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: oxalate(2-)
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
is: HMDB02329
initial concentration: 1.0

metaM c4dc c
notes: FORMULA: C11H18NO6 CHARGE: -1
is: SBO:0000247
is: HMDB04047
initial concentration: 1.0
boundary condition: false
name: succinyl carnitine
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: C14143

metaR ACITL
name: ATP-Citrate lyase
is version of: http://identifiers.org/ec-code/2.3.3.8
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is: SBO:0000176
product: MODEL1310110044#
type: Reaction
fast: false
kinetic law: MODEL1310110044#

metaR RE1534M
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
reversible: true
name: RE1534

metaR r2021
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110044#

metaR r1692
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: false

metaR r0381
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110044#
type: Reaction
fast: false
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110044#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

http://identifiers.org/biomodels.db/MODEL1310110044#_d96797d6_644e_4612_8853_cf33c62a80db
is: SBO:0000252
name: ACSS1
initial concentration: NaN
is encoded by: hsa:84532
has only substance units: false
type: Species
boundary condition: true
constant: false
is: Q9NUB1
initial amount: NaN

metaR FAOXC225C226m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM lnlncgcoa c
constant: false
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: CHEBI:57363
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR ACALDtm
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: acetaldehyde mitochondrial diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction

metaR 5MTHFt
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
reactant: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
type: Reaction
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000269
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis

metaM HC01434 c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
initial amount: NaN
has only substance units: false
is: CHEBI:58931
initial concentration: 1.0
type: Species

metaR r0669
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_873601b1_8e6b_4585_9bdb_2b939fb0ef3a
initial concentration: NaN
has only substance units: false
name: ACP1
boundary condition: true
initial amount: NaN
is: Q59EH3
constant: false
is: SBO:0000252
is encoded by: hsa:52
type: Species

metaR R group phosphotase 1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 1
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#

metaM ppi c
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3
type: Species
is: SBO:0000247
constant: false
name: Diphosphate
is: HMDB00250
initial concentration: 1.0
is: C00013
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110044#_6923fb3f_297f_4dff_82ed_7af2af2a54b8
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9H310
type: Species
is encoded by: hsa:57127
name: RHBG

metaR GALt4
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110044#
reversible: true
type: Reaction
name: galactose transport via sodium symport

metaR FAOXC143C123m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM xol7ah2al c
boundary condition: false
has only substance units: false
constant: false
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_9e3eadbe_bd67_4f11_8edc_9ed1b1c43b09
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:H45672
name: _H45672_1_m
has only substance units: false

metaM msa m
constant: false
name: 3-oxopropanoate
has only substance units: false
initial amount: NaN
is: CHEBI:33190
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222

metaR r1691
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
is: SBO:0000185

metaR THYOXt
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
is: SBO:0000185
name: T4 transport via bicarbonate countertransport

metaM atp x
is: HMDB00538
constant: false
type: Species
is: C00002
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57299
has only substance units: false
name: ATP(4-)
initial concentration: 1.0

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM 3aib D m
has only substance units: false
constant: false
boundary condition: false
is: HMDB02299
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
name: D-3-Amino-isobutanoate
is: C03265

http://identifiers.org/biomodels.db/MODEL1310110044#_0332c7ce_5c3a_4d1f_999a_880e6f38a9b1
is: SBO:0000252
type: Species
name: UCK1
has only substance units: false
boundary condition: true
is: Q5JT09
is encoded by: hsa:83549
initial amount: NaN
initial concentration: NaN
constant: false

metaM 1pyr5c m
is: HMDB01301
initial amount: NaN
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate
is: C03912
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_44e2abd9_6a4f_48d0_916e_bbc38d21b96e
boundary condition: true
name: PDE1A
type: Species
is: P54750
is encoded by: hsa:5136
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fa843f3d_2db2_46b1_be01_3ebd9c8ca3c8
is encoded by: hsa:79611
initial amount: NaN
is: Q9H6R3
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ACSS3
type: Species

metaM pi c
has only substance units: false
type: Species
boundary condition: false
name: hydrogenphosphate
is: C00009
is: HMDB00973
is: CHEBI:43474
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM crn e
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
type: Species
is: CHEBI:16347
is: C00318
boundary condition: false
name: L-Carnitine
is: HMDB00062
initial concentration: 1.0

metaM nadh m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
is: HMDB01487
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: CHEBI:57945
initial amount: NaN

metaR FAOXC201C181x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r2509
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_2c37daa3_6bb5_4e84_b4c8_e49dedf37df6
is encoded by: hsa:2348
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: FOLR1

metaM 2hexdtricoa m
is: HMDB02288
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR GCC2cm
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: glycine-cleavage complex (lipoamide), mitochondrial
is: SBO:0000176
reversible: true

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_2ace2552_aedd_4c5b_928f_9617945743d2
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:641371
name: ACOT1
is: E9KL42
initial amount: NaN
has only substance units: false
boundary condition: true

metaR RE1845X
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
name: RE1845
kinetic law: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_541f91d8_6816_48d3_b3b4_8e67f7faddaa
type: Species
initial concentration: NaN
name: AOC2
is: SBO:0000252
is: O75106
constant: false
is encoded by: hsa:314
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_167ebd55_9878_45c4_8251_e01975cc3242
name: MGST2
initial concentration: NaN
is: D6RBB5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4258
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR PROSTGE2t
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#

metaR SRTNt6 2 r
product: MODEL1310110044#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
reactant: MODEL1310110044#
fast: false
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_9f199b48_9c62_4e0d_b980_c73bf127faa1
is: Q9BV79
is encoded by: hsa:51102
is: SBO:0000252
boundary condition: true
has only substance units: false
name: MECR
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM ppi e
has only substance units: false
initial amount: NaN
is: CHEBI:33019
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
type: Species
boundary condition: false
name: Diphosphate
constant: false
is: C00013
initial concentration: 1.0

metaR r2508
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2bc6eaac_00f7_46af_8b1e_2bb33695f3a1
is encoded by: hsa:5151
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PDE8A
initial amount: NaN

metaM xol7aone m
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01993
has only substance units: false
is: CHEBI:17899
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
boundary condition: false

metaM hx2coa m
has only substance units: false
name: trans-Hex-2-enoyl-CoA
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247

metaR MTHFCm
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial

metaR r2020
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110044#_f37923d0_1e4d_4a0c_8753_5df04c09af3f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:23428
type: Species
initial concentration: NaN
is: Q86U05
initial amount: NaN
boundary condition: true
name: SLC7A8
constant: false

metaM idp c
is: HMDB03335
has only substance units: false
name: IDP(3-)
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM lnlnca r
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: CHEBI:32387
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01388

metaM 5tedtricoa m
type: Species
name: 5,8,11-tetradecatrienoylcoa
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: HMDB02288
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaM hom L e
type: Species
name: L-homoserine
has only substance units: false
is: SBO:0000247
is: HMDB00719
boundary condition: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15699

http://identifiers.org/biomodels.db/MODEL1310110044#_550e1af5_59cb_4838_ab7f_232e8e52bcad
is encoded by: hsa:6534
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC6A7
type: Species
initial concentration: NaN
is: Q99884
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_a4f3d90e_42c6_42ed_b61e_e0367a099591
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AI539321
boundary condition: true
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110044#_5299adc4_b09c_4f1c_8785_5b08eb50a438
is encoded by: hsa:115
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: ADCY9
has only substance units: false
initial concentration: NaN
is: O60503

metaR 3SPYRSP
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)
product: MODEL1310110044#

metaM hdd2coa m
constant: false
initial amount: NaN
is: C05272
has only substance units: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:61526
name: trans-Hexadec-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110044#_1969b182_d455_45ed_9143_840baaff9e22
boundary condition: true
type: Species
is encoded by: hsa:80347
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q13057
constant: false
name: COASY
initial concentration: NaN

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR DHCRD1
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reversible: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
name: dihydroceramide desaturase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_c7a1b04c_617e_48d0_b298_a9e742be7765
is: SBO:0000252
is: Q9UGH3
has only substance units: false
boundary condition: true
name: SLC23A2
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:9962

metaM accoa m
initial amount: NaN
is: CHEBI:57288
has only substance units: false
is: HMDB01206
is: C00024
type: Species
initial concentration: 1.0
name: Acetyl-CoA
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false

metaR FAOXC102C103m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR OMHPALTD
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM crn c
is: HMDB00062
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
name: L-Carnitine
initial concentration: 1.0
is: CHEBI:16347
is: C00318
has only substance units: false
type: Species

metaR r1611
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction

metaR r0385
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_7e0e4571_7803_4bde_afe4_67cd86f11850
initial amount: NaN
has only substance units: false
is: D9HTE9
name: SLC25A1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6576

metaM gthox c
is: CHEBI:58297
initial amount: NaN
constant: false
is: SBO:0000247
name: Oxidized glutathione
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00127
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species
is: HMDB03337

http://identifiers.org/biomodels.db/MODEL1310110044#_e820463a_ea27_4581_a1fb_04cfb7cf5851
is: SBO:0000252
is encoded by: hsa:50808
name: AK3
type: Species
initial concentration: NaN
is: E7ET30
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR DCSPTN1CRNt
fast: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR PCHOL HSter
fast: false
reactant: MODEL1310110044#
name: phosphatidylcholine scramblase
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:

metaM 2maacoa m
boundary condition: false
is: CHEBI:57335
is: HMDB01157
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
name: 2-methylacetoacetyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species

metaR r0456
type: Reaction
reversible: false
product: MODEL1310110044#
is described by: ECO:0000000
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.32
fast: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_564375cc_72d1_4d27_8f4c_5a04d5286cbe
type: Species
boundary condition: true
is: Q99808
name: SLC29A1
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2030

metaR CBR2
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false
name: Carbonyl reductase [NADPH] 1
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.189
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
fast: false

metaR NADtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
reversible: true
is: SBO:0000185
name: NAD transport, nuclear through pores

metaR r1612
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#

metaR r1538
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
type: Reaction

metaR HMGCOASim
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
fast: false
reversible: false
modifier: MODEL1310110044#
is described by: ECO:0000269
reactant: MODEL1310110044#
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction
kinetic law: MODEL1310110044#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM retinol 9 cis e
is: CHEBI:17336
is: HMDB06217
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
has only substance units: false
name: 9-cis-retinol
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_fc7aa285_5e73_4ee5_868e_3192ae3bd75c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI291895
name: _AI291895_1_c
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_1a5c36e6_01c8_4323_8af0_a9694b207fca
is encoded by: hsa:84889
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: SLC7A3
initial concentration: NaN
is: SBO:0000252
is: Q8WY07

metaM HC01603 c
is: SBO:0000247
is: CHEBI:57454
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
is: C00234
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
type: Species
boundary condition: false

metaR r0942
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_9eec2ce5_d3c9_4eb8_a73b_f1f14f3e2ef8
type: Species
is: SBO:0000252
is: P05091
initial amount: NaN
is encoded by: hsa:217
boundary condition: true
name: ALDH2
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_1cbf033b_959a_4b7c_8e56_9d794bec0611
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _AA526438_1_c
is encoded by: hsa:AA526438

metaR r0384
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110044#
type: Reaction
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_e78a2399_9e79_4fad_9aa7_f29646efc374
initial concentration: NaN
is: SBO:0000252
type: Species
name: PLCD3
has only substance units: false
is encoded by: hsa:113026
is: Q8N3E9
boundary condition: true
initial amount: NaN
constant: false

metaM 3mob e
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: 3-methyl-2-oxobutanoate
is: HMDB00019
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_a6680e23_268a_47a0_88bf_c67cc51b6105
boundary condition: true
is: E9PCI1
initial concentration: NaN
name: ACP2
has only substance units: false
is encoded by: hsa:53
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR C4STMO2r
is described by: ECO:0000000
modifier: MODEL1310110044#
name: C-4 methyl sterol oxidase
fast: false
reactant: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.14.13.72
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR CYSO
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
reversible: false
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
is described by: ECO:0000269
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_9e8c5911_b316_4bf9_b611_bb143b3953bc
has only substance units: false
boundary condition: true
name: AKR1C4
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:1109
is: P17516

http://identifiers.org/biomodels.db/MODEL1310110044#_5cf398a5_4ecd_4038_b1d6_291755226f52
type: Species
initial concentration: NaN
is encoded by: hsa:5092
name: PCBD1
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR ACACT10m
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
product: MODEL1310110044#

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d5072078_007e_4c30_bb52_96a0eb80d318
is encoded by: hsa:206358
initial concentration: NaN
constant: false
type: Species
name: SLC36A1
is: Q1LZ56
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r0941
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true
type: Reaction

metaM c4dc e
notes: FORMULA: C11H18NO6 CHARGE: -1
is: HMDB04047
type: Species
is: SBO:0000247
initial amount: NaN
name: succinyl carnitine
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C14143

metaM CE2431 m
constant: false
name: cis-deca-4-enoyl-CoA
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57795
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431

http://identifiers.org/biomodels.db/MODEL1310110044#_d26e97c7_0173_4707_bddb_6dccb4de657e
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: ENTPD3
is: O75355
constant: false
is encoded by: hsa:956
boundary condition: true

metaR MCLOR
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 3-Mercaptolactate:NAD+ oxidoreductase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR CLS hs
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
name: cardiolipin synthase (homo sapiens)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_aaef867f_5d76_4679_b622_ea2972214349
has only substance units: false
type: Species
boundary condition: true
name: INPP5D
is encoded by: hsa:3635
initial concentration: NaN
is: Q92835
is: SBO:0000252
initial amount: NaN
constant: false

metaM xol7aone r
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
initial concentration: 1.0

metaM dump c
constant: false
is: CHEBI:246422
type: Species
name: dUMP
is: C00365
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM retinol 9 cis c
is: SBO:0000247
is: CHEBI:17336
boundary condition: false
initial concentration: 1.0
is: HMDB06217
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
name: 9-cis-retinol
constant: false
initial amount: NaN
type: Species

metaM fru e
constant: false
is: CHEBI:15824
is: HMDB00660
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
name: D-Fructose
is: C00095
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR SUCCTD
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR r1610
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

metaM accoa n
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57288
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206

metaR r0940
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Free diffusion
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000

metaM amp m
is: SBO:0000247
initial concentration: 1.0
is: HMDB00045
is: CHEBI:456215
name: AMP(2-)
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

http://identifiers.org/biomodels.db/MODEL1310110044#_57dc6814_645a_4231_bf8c_7ad71826eee6
is: SBO:0000252
is: P11310
initial amount: NaN
is encoded by: hsa:34
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: ACADM
boundary condition: true

metaM CE0713 m
has only substance units: false
constant: false
name: 3-oxolinoleoyl-CoA
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
initial concentration: 1.0
is: HMDB02329
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_2c8c151a_010a_47ea_a9ee_eed40a08e67d
has part: P23921
is encoded by: hsa:6240
initial concentration: NaN
is: SBO:0000297
constant: false
name: RRM1:RRM2
type: Species
is encoded by: hsa:6241
has only substance units: false
has part: P31350
initial amount: NaN
boundary condition: true

metaM 3mob c
initial amount: NaN
is: CHEBI:11851
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
name: 3-methyl-2-oxobutanoate
constant: false
is: HMDB00019
is: SBO:0000247
type: Species

metaR DURIt
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
type: Reaction
name: deoxyuridine transport via diffusion

metaM nadh r
has only substance units: false
boundary condition: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57945
is: HMDB01487
name: NADH(2-)

metaM 3hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
constant: false
is: HMDB02288
has only substance units: false

metaM ump c
type: Species
name: UMP
is: CHEBI:57865
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: SBO:0000247
initial amount: NaN
is: C00105
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_fd2568e4_03cb_4611_ac66_537e1085430d
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:AA977580
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AA977580_1_c

metaM 3hmbcoa m
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false
has only substance units: false
is: HMDB01356
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: CHEBI:57312
initial concentration: 1.0

metaM tcynt e
has only substance units: false
type: Species
is: HMDB01453
initial concentration: 1.0
initial amount: NaN
name: thiocyanate
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR UMPK4n
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
name: UMP kinase (GTP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110044#_9a581c26_b2e1_43da_8244_e5010de72b73
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:9962
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC23A2

http://identifiers.org/biomodels.db/MODEL1310110044#_dbb143c9_53c3_4105_a9ad_1e3a152abff3
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q96PL7
name: SLC28A1
is: SBO:0000252
is encoded by: hsa:9154
initial amount: NaN
type: Species

metaR r2097
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_68a63990_986a_49f0_abf8_986c10074024
name: NDUFS7
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:374291
is: O75251
type: Species

metaR UGT1A10r
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.4.1.17
is described by: ECO:0000134
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_345c9f5f_b688_46f1_92bd_ee66433d6dbb
is encoded by: hsa:10786
constant: false
name: SLC17A3
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: O00476
boundary condition: true
initial concentration: NaN

metaM pail hs c
constant: false
is: SBO:0000247
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
type: Species
initial concentration: 1.0

metaR CYTK14
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
name: cytidylate kinase (dCMP,UTP)
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_ab6ef800_e630_47f9_8b3c_0309f7166de4
has part: Q8TF08
is encoded by: hsa:4512
has part: H0UI06
has part: P14854
type: Species
is encoded by: hsa:170712
has part: Q53YB7
has only substance units: false
is encoded by: hsa:341947
is encoded by: hsa:1349
has part: Q7GXZ8
is encoded by: hsa:1339
constant: false
has part: Q6YFQ2
has part: P24310
is encoded by: hsa:1346
has part: P09669
is encoded by: hsa:1351
is: SBO:0000297
has part: Q6FGA0
has part: P12074
has part: Q7GXY8
initial concentration: NaN
is encoded by: hsa:1329
has part: Q02221
has part: P24311
has part: P13073
initial amount: NaN
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1345
has part: P00414
is encoded by: hsa:4514
boundary condition: true
is encoded by: hsa:9377
is encoded by: hsa:1337
is encoded by: hsa:1340
is encoded by: hsa:9167
is encoded by: hsa:84701
has part: Q7Z4L0
has part: Q96KJ9
is encoded by: hsa:1347
has part: P15954
is encoded by: hsa:1327
is encoded by: hsa:1350
has part: Q53XN1
has part: P20674
is encoded by: hsa:4513
is encoded by: hsa:125965

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110044#_4632620f_1bcc_4e55_b2f9_ee5d433fd3bb
is encoded by: hsa:1854
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: P33316
name: DUT

http://identifiers.org/biomodels.db/MODEL1310110044#_fc91f1f1_c35f_4173_b0d8_61074bf05191
boundary condition: true
type: Species
is encoded by: hsa:1376
has only substance units: false
is: SBO:0000252
constant: false
name: CPT2
is: P23786
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_4db6840b_c290_493b_b950_5007a30c8ba7
is encoded by: hsa:6120
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
name: RPE
is: Q96AT9
initial amount: NaN

metaM peamn c
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial concentration: 1.0
is: CHEBI:225237
is: HMDB12275
initial amount: NaN
is: SBO:0000247
name: 2-phenylethanaminium
type: Species

metaM trdrd m
type: Species
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:15967
name: Reduced thioredoxin
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_eb1b9a9b_9dcb_4d5b_b360_6c16510a92d5
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P28332
type: Species
name: ADH6
is encoded by: hsa:130
constant: false
is: SBO:0000252

metaR SPHMDAc
reactant: MODEL1310110044#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES:limited details on mechanism, localization, etc. See PMID: 12069827 NJ
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: sphingomyelin deacylase
reversible: false
product: MODEL1310110044#

metaM prostgi2 c
name: prostaglandin I2(1-)
initial amount: NaN
is: HMDB01335
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r2015
fast: false
product: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
type: Reaction

metaR r2098
modifier: MODEL1310110044#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM nh4 m
is: HMDB00051
type: Species
is: C01342
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
is: CHEBI:28938
initial amount: NaN
constant: false
initial concentration: 1.0

metaM dag hs c
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:18035
name: diglyceride

metaM 3dodtricoa m
boundary condition: false
has only substance units: false
name: 3,6,9-dodecatrienoylcoa
initial amount: NaN
constant: false
is: SBO:0000247
is: C05280
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: HMDB03952

metaR IMPC
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reversible: true
name: IMP cyclohydrolase
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_d79657e4_3a90_4686_912e_203aa8ee8a94
boundary condition: true
is encoded by: hsa:83715
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: ESPN
is: B1AK53
initial concentration: NaN
type: Species

metaR r0523
fast: false
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#

metaM lanost r
type: Species
is: SBO:0000247
name: lanosterol
is: HMDB01251
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: CHEBI:16521
has only substance units: false

metaM pe hs r
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
initial concentration: 1.0
is: CHEBI:16038
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM tcynt c
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
boundary condition: false
is: HMDB01453
is: SBO:0000247
constant: false
is: CHEBI:18022
has only substance units: false
initial concentration: 1.0
name: thiocyanate
initial amount: NaN

metaR r0934
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
reversible: false
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110044#

metaR r2095
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110044#

metaM so4 e
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
is: CHEBI:16189
constant: false
name: sulfate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01448
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_119f8c55_8794_482f_95bc_80a803252c14
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:22934
name: RPIA
is: P49247
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaM lnlnca l
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:32387
initial amount: NaN
constant: false
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_1f546ccf_c1f2_4b99_a683_1b341422f0e3
type: Species
initial amount: NaN
boundary condition: true
name: MTMR3
is: SBO:0000252
is encoded by: hsa:8897
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_212a2336_dd8c_46bf_bd9e_5965942cd7e2
type: Species
is: Q96C36
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:29920
name: PYCR2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR FACOAL180i
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110044#
type: Reaction
reversible: false
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000176
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
name: C180 fatty acid activation
product: MODEL1310110044#

metaR CYTK12
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP)
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

metaM CE0849 m
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
name: cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:57795
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_3ee580d5_91c7_4549_bbef_a66eca337284
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: P15309
is encoded by: hsa:55
name: ACPP
constant: false
initial concentration: NaN

metaR NTD6
modifier: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110044#
fast: false
is: SBO:0000176
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110044#
name: 5'-nucleotidase (dAMP)
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR LYStip
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
name: L-lysine transport, peroxisomal (irreversible)
reversible: false
is described by: ECO:0000000
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_1af7b0cf_fca7_478f_bf58_e7b202b8ebe7
boundary condition: true
is encoded by: hsa:AA081045
name: _AA081045_1_m
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR DM atp c
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: DM atp(c)
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110044#

metaR r1551
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM dag hs e
constant: false
name: diglyceride
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaR r0451
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
fast: false
reactant: MODEL1310110044#
is: SBO:0000176
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2

http://identifiers.org/biomodels.db/MODEL1310110044#_e0d5662f_10d1_4cfd_ba34_0739f66818a6
type: Species
has only substance units: false
initial amount: NaN
name: _M68895_1_c
boundary condition: true
is encoded by: hsa:M68895
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r2096
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
constant: false
boundary condition: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
has only substance units: false
is: C00119
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58017
is: HMDB00280
initial amount: NaN

metaM 1pyr5c c
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: C03912
boundary condition: false
is: HMDB01301
initial concentration: 1.0
has only substance units: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_5dba2849_e4ee_4722_80b4_14fe03eac60f
type: Species
constant: false
is: E7EX19
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PIK3R1
is encoded by: hsa:5295
boundary condition: true

metaR CYTK13
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
name: cytidylate kinase (dCMP,dATP)

metaR PI45PLC
kinetic law: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
product: MODEL1310110044#
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
modifier: MODEL1310110044#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110044#
type: Reaction

metaM Lpipecol x
type: Species
is: SBO:0000247
constant: false
is: HMDB00716
has only substance units: false
initial concentration: 1.0
name: L-pipecolic acid
initial amount: NaN
is: CHEBI:30913
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
boundary condition: false

metaR FAOXC101m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_1ac09f0d_e293_4069_a2f9_08a3c8cc6648
constant: false
type: Species
initial amount: NaN
name: MTMR3
is: SBO:0000252
is encoded by: hsa:8897
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ptth c
is: SBO:0000247
has only substance units: false
type: Species
name: pantetheine
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB03426
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaM so4 c
has only substance units: false
is: SBO:0000247
name: sulfate
is: HMDB01448
is: CHEBI:16189
constant: false
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_cc4313b1_241c_44a9_9336_35a73e4f4f49
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4522
constant: false
name: MTHFD1
is: P11586
type: Species
boundary condition: true
has only substance units: false

metaR FAOXC142C122m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaR r0936
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
name: Transport reaction
fast: false

metaM aicar c
boundary condition: false
is: HMDB01517
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
constant: false
is: C04677
has only substance units: false
is: CHEBI:58475
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
type: Species

metaR CYTK10
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110044#
reversible: true
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176

metaR r0450
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
reactant: MODEL1310110044#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176

metaR NTD7
kinetic law: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (AMP)
reversible: false
reactant: MODEL1310110044#
is: SBO:0000176

metaR r2093
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_6c80b449_4924_4c41_80fc_4090a93ac0d8
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:230
initial amount: NaN
name: ALDOC
is: SBO:0000252
is: P09972

metaR r1552
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_2bf0d346_d448_4543_a4b8_4f94dddce7f2
has only substance units: false
name: ACSS2
is encoded by: hsa:55902
is: SBO:0000252
initial concentration: NaN
is: Q5QPH3
constant: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_30aa3ab9_1d1e_407c_8485_2c7def9bd8fa
name: _AI653169_1_c
boundary condition: true
type: Species
constant: false
is encoded by: hsa:AI653169
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR FAOXC181C161x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaM pi x
is: SBO:0000247
constant: false
is: HMDB00973
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
name: hydrogenphosphate
initial concentration: 1.0
is: CHEBI:43474
boundary condition: false
type: Species

metaM HC01397 m
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:27402
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_913452f3_80da_476b_8ec4_02c6e8e6c1a4
is: Q8NFM4
initial amount: NaN
constant: false
name: ADCY4
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:196883
is: SBO:0000252
initial concentration: NaN

metaR PI345P3P
reversible: false
kinetic law: MODEL1310110044#
type: Reaction
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
modifier: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.67
is: SBO:0000176
is described by: ECO:0000000

metaM gthox m
boundary condition: false
is: SBO:0000247
is: CHEBI:58297
is: HMDB03337
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

http://identifiers.org/biomodels.db/MODEL1310110044#_26a2687f_8b15_4322_8426_902de580e867
boundary condition: true
is encoded by: hsa:30
constant: false
initial amount: NaN
name: ACAA1
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q96CA6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c808b970_d3c6_498e_9674_da3f5c32fb68
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:5290
constant: false
is: SBO:0000252
name: PIK3CA
is: P42336
initial concentration: NaN

metaR NODe
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110044#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
name: NODe

metaR DNDPt28m
name: dCDP transport via dGDP antiport
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110044#
type: Reaction
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_8bc22f63_baa1_4983_9e4d_a68bc9d36312
name: ACAD9
is encoded by: hsa:28976
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q9H845

metaM gly c
is: CHEBI:3339
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
type: Species
initial amount: NaN
is: C00037
name: Glycine

metaR MTHFD2
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reactant: MODEL1310110044#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000134
modifier: MODEL1310110044#
name: methylenetetrahydrofolate dehydrogenase (NAD)

metaM lnlnca e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
name: alpha-linolenate
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:32387
is: HMDB01388

metaR r0937
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Transport reaction

metaR r1553
is: SBO:0000185
kinetic law: MODEL1310110044#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR 5HLTDL
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000269
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
reversible: false
reactant: MODEL1310110044#
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
fast: false

metaR r2094
is: SBO:0000185
fast: false
modifier: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_6bea79c7_3876_43e4_be83_e9dcaf148fb4
constant: false
name: CPT1B
initial concentration: NaN
is encoded by: hsa:1375
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q53FV7
has only substance units: false

metaR FATP2t
fast: false
reversible: true
reactant: MODEL1310110044#
is described by: ECO:0000269
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
kinetic law: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_98b85544_2d3c_4b57_a06e_3f0ebd246ef5
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AI640625_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI640625
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_9a13a76d_bb73_4529_b73d_d30baaf9d980
constant: false
type: Species
initial amount: NaN
name: PEMT
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10400
is: SBO:0000252

metaM ethamp r
constant: false
is: HMDB00224
initial amount: NaN
name: O-phosphonatoethanaminium(1-)
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_b5629fb0_4875_43d5_b6b4_e4e6a30eab59
is: SBO:0000252
is: Q96CA6
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:30
boundary condition: true
has only substance units: false
name: ACAA1
type: Species

metaR CYTK11
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: cytidylate kinase (dCMP,dGTP)
fast: false

metaM mthgxl c
has only substance units: false
initial concentration: 1.0
name: methylglyoxal
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17158
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
is: HMDB01167

metaM mi1345p c
boundary condition: false
is: HMDB01059
is: SBO:0000247
is: CHEBI:57895
initial amount: NaN
initial concentration: 1.0
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
type: Species
constant: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_174fba89_b273_4f42_a859_154ec5aad68f
is: SBO:0000252
name: UCP2
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: P55851
is encoded by: hsa:7351

http://identifiers.org/biomodels.db/MODEL1310110044#_55e126cb_10ae_4e9e_985c_27fcff1e81f0
boundary condition: true
initial concentration: NaN
type: Species
is: P19440
is encoded by: hsa:2678
has only substance units: false
constant: false
is: SBO:0000252
name: GGT1
initial amount: NaN

metaR NDPK7n
kinetic law: MODEL1310110044#
is described by: ECO:0000304
reversible: true
product: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_72a8b75b_a919_4d8e_9fc6_75cc6ae0ccd6
has only substance units: false
name: SCD
initial concentration: NaN
constant: false
is: O00767
boundary condition: true
is encoded by: hsa:6319
type: Species
initial amount: NaN
is: SBO:0000252

metaR NDPK10
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110044#_3aefc33c_4893_448e_b63e_5ccc66559a42
is encoded by: hsa:92579
is: SBO:0000252
initial concentration: NaN
type: Species
name: G6PC3
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9BUM1

metaM ptth e
type: Species
has only substance units: false
name: pantetheine
boundary condition: false
initial amount: NaN
constant: false
is: HMDB03426
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1
is: SBO:0000247
is: CHEBI:16753

metaM 6a2ohxnt x
initial amount: NaN
boundary condition: false
is: CHEBI:17534
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: SBO:0000247
is: HMDB12151
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: 6-amino-2-oxohexanoic acid

metaM 20ahchsterol m
boundary condition: false
initial concentration: 1.0
is: CHEBI:1296
type: Species
is: HMDB06283
initial amount: NaN
constant: false
name: 20-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false
is: SBO:0000247

metaR NADPHtru
name: NADPH transporter, endoplasmic reticulum
product: MODEL1310110044#
reversible: false
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
fast: false

metaR NTD9
reversible: false
is described by: ECO:0000134
name: 5'-nucleotidase (GMP)
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM glyc m
initial amount: NaN
name: Glycerol
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17754
is: HMDB00131
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110044#_09400ff1_e55c_45cb_9bff_ec209832ee53
initial concentration: NaN
name: MPST
is encoded by: hsa:4357
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: P25325

metaM dhcholestancoa x
constant: false
is: HMDB02159
initial amount: NaN
is: CHEBI:15494
boundary condition: false
initial concentration: 1.0
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: SBO:0000247
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false

metaM aicar e
initial concentration: 1.0
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
is: SBO:0000247
is: CHEBI:58475
has only substance units: false
type: Species
is: C04677
notes: FORMULA: C9H13N4O8P CHARGE: -2
boundary condition: false
constant: false
is: HMDB01517

metaR r1554
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1988
is: SBO:0000185
reversible: false
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_acd73543_d226_4f11_be68_638ce5fa3334
initial concentration: NaN
name: SUCLA2
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: E5KS60
is encoded by: hsa:8803
boundary condition: true

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_1c7fd619_cfa7_4ec8_88d7_cc873011b3e3
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: HSD17B10
is encoded by: hsa:3028
boundary condition: true
type: Species
initial concentration: NaN
is: Q99714

metaR MDHx
kinetic law: MODEL1310110044#
name: malate dehydrogenase, peroxisomal
reactant: MODEL1310110044#
is: SBO:0000176
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
is described by: ECO:0000134
product: MODEL1310110044#

metaR CYTK11n
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: cytidylate kinase (dCMP,dGTP),nuclear
is described by: ECO:0000269
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110044#
product: MODEL1310110044#

metaM ade c
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
constant: false
has only substance units: false
initial amount: NaN
is: C00147
initial concentration: 1.0
is: HMDB00034
name: Adenine
is: SBO:0000247
boundary condition: false
is: CHEBI:16708

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_6c0bb9d2_5db3_401d_93f6_e8db50d49e38
is: E9KL44
initial amount: NaN
constant: false
name: HADHA
is encoded by: hsa:3030
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR UDPGLCter
reversible: true
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR DNDPt21m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
is: SBO:0000185
modifier: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
name: dTDP transport via ADP antiport

metaM 34dhoxmand c
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 3,4-Dihydroxymandelate
constant: false
is: HMDB01866
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

http://identifiers.org/biomodels.db/MODEL1310110044#_2baef384_7111_4740_8852_da6219f02b22
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3948
constant: false
type: Species
name: LDHC
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ead9fedd_6c80_462b_80b1_35cf3693abc6
boundary condition: true
is: P48067
is encoded by: hsa:6536
constant: false
has only substance units: false
type: Species
name: SLC6A9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r2092
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110044#

metaR FAOXC122m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR P450SCC1m
reactant: MODEL1310110044#
reversible: true
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is: SBO:0000176
type: Reaction
name: cholesterol monooxygenase
is described by: ECO:0000134

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00508
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15963

metaM CE4876 r
is: CHEBI:57923
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: delta12-Prostaglandin J2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

metaR r1986
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR BPNT
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.7
reactant: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
reversible: false
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110044#

metaM ade e
initial concentration: 1.0
name: adenine
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: HMDB00034
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_4200a7b1_6589_4233_81eb_4f87db0d4825
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:NM 013421
constant: false
name: _NM_013421_1_e
type: Species
boundary condition: true

metaR CYSTA
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110044#
fast: false
type: Reaction
name: cysteine transaminase
kinetic law: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#

metaR PI5P3K
type: Reaction
product: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
fast: false
is: SBO:0000176
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.137
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR PA HStg
product: MODEL1310110044#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110044#
name: phosphatidate scramblase

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110044#

metaR UMPK
name: UMP kinase
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_40b6acf7_9e9d_458b_8c48_dfdb455953c0
is encoded by: hsa:23396
is: O60331
type: Species
initial amount: NaN
has only substance units: false
name: PIP5K1C
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR EX doco13ac
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
is: CHEBI:57397
name: prostaglandin E1(1-)
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01442
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_989ea8f9_f1cd_400b_b01f_e45741aa2530
name: ADCY3
is: B3KT86
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:109
is: SBO:0000252
type: Species

metaR r1609
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110044#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE5117 m
initial amount: NaN
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial concentration: 1.0
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaR r1904
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110044#
is described by: ECO:0000000

metaM 2docopencoa m
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790

metaR ARGtm
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: arginine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_30517b8e_1e9d_4ee2_896b_a1246b2e9668
type: Species
initial concentration: NaN
has only substance units: false
is: Q308M7
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5169
constant: false
initial amount: NaN
name: ENPP3

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM nh4 e
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:28938
name: ammonium
is: HMDB00051
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110044#
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
fast: false
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110044#_434bc170_c897_44d9_b625_4f6bac174537
initial amount: NaN
initial concentration: NaN
is: E9PAK4
has only substance units: false
boundary condition: true
is encoded by: hsa:200010
constant: false
name: SLC5A9
type: Species
is: SBO:0000252

metaR RDH1a
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (all-trans,NADPH)
is: SBO:0000176
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_c0d52500_37de_4ff1_85b8_aaba5ea4459d
type: Species
has only substance units: false
is encoded by: hsa:2821
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GPI
constant: false
is: P06744

metaR r0680
fast: false
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
product: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000000
is: SBO:0000176

metaR HMGCOARc
fast: false
is described by: ECO:0000134
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
reversible: false
product: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).

metaR RE2649C
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
type: Reaction
reversible: true
name: RE2649
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.2

http://identifiers.org/biomodels.db/MODEL1310110044#_a80c2163_b657_4d92_96b3_6d82c79bf135
name: PDE8B
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:8622
is: O95263
type: Species
initial concentration: NaN
has only substance units: false

metaR r1984
reversible: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110044#
is: SBO:0000185

metaM 5aizc c
is: C04751
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06273
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
constant: false
is: CHEBI:58564

http://identifiers.org/biomodels.db/MODEL1310110044#_91126c05_44b8_41b1_a5c8_cb573f6e9404
is: P48651
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PTDSS1
type: Species
constant: false
is encoded by: hsa:9791

metaM HC01397 x
has only substance units: false
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
initial amount: NaN
initial concentration: 1.0

metaM gchola e
boundary condition: false
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00138
type: Species

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR IPDDIx
kinetic law: MODEL1310110044#
fast: false
name: isopentenyl-diphosphate D-isomerase
type: Reaction
is described by: ECO:0000134
product: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/5.3.3.2
is: SBO:0000176

metaR CYSTALArBATtc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM octe5coa m
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 5-octenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110044#_dcc5b80f_d2c6_47f4_a38d_0fcd292d5139
is: SBO:0000252
constant: false
initial amount: NaN
is: P25325
name: MPST
initial concentration: NaN
is encoded by: hsa:4357
has only substance units: false
boundary condition: true
type: Species

metaM so4 m
boundary condition: false
name: sulfate
is: HMDB01448
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16189
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110044#_2fa63260_04a6_47ce_b453_de5e36059d24
name: KL
is: Q9UEF7
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:9365
is: SBO:0000252
type: Species

metaM prostge1 c
name: prostaglandin E1(1-)
is: SBO:0000247
is: CHEBI:57397
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01442
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

http://identifiers.org/biomodels.db/MODEL1310110044#_05c5f8b2_bbbf_478a_8360_3fe486bf431b
initial amount: NaN
name: TK2
has only substance units: false
is encoded by: hsa:7084
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: O00142

metaM pi r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: C00009
has only substance units: false
constant: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
is: CHEBI:43474
name: hydrogenphosphate

metaR r0829
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110044#
is: SBO:0000185
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37

http://identifiers.org/biomodels.db/MODEL1310110044#_ed1ba5c8_3168_40e8_89fd_030ffac2aa61
initial concentration: NaN
is: Q96RN1
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: SLC26A8
is encoded by: hsa:116369

metaR CH25H
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false
type: Reaction
name: cholesterol 25-hydroxylase
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.99.38
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_350ae215_8072_43bc_9887_fd5545a1e185
type: Species
boundary condition: true
is: SBO:0000252
is: Q6FGV9
name: PMVK
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10654
constant: false

metaR PTPATe
name: PTPATe
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110044#

metaM lnlnca c
is: HMDB01388
is: CHEBI:32387
initial concentration: 1.0
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

metaR r1832
reactant: MODEL1310110044#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#
is described by: ECO:0000000

metaR r1985
kinetic law: MODEL1310110044#
name: Y+LAT2 Utilized transport
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
reactant: MODEL1310110044#
type: Reaction

metaM pro L m
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: L-proline
type: Species
is: HMDB00162
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM pail hs n
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57880

metaM nh4 c
boundary condition: false
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
constant: false
initial amount: NaN
is: C01342
is: SBO:0000247
type: Species
is: CHEBI:28938
has only substance units: false
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110044#_a0144d30_3761_4ce1_ae19_b351d466cb7e
initial concentration: NaN
is: P07451
has only substance units: false
type: Species
is encoded by: hsa:761
boundary condition: true
is: SBO:0000252
name: CA3
constant: false
initial amount: NaN

metaM arachdcoa c
type: Species
is: HMDB06523
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
is: CHEBI:57368

metaR PItx
fast: false
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Phosphate transporter, peroxisome

metaM crn x
is: CHEBI:16347
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
constant: false
is: C00318
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00062
type: Species

metaR Uritm
modifier: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110044#
fast: false
name: uridine facilated transport in mitochondria
reversible: true
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_165f0b11_a253_4b16_b66f_2e23c9c9c2e8
is encoded by: hsa:2639
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: GCDH
is: Q92947
boundary condition: true
initial amount: NaN

metaM gchola c
constant: false
is: HMDB00138
type: Species
initial concentration: 1.0
name: glycocholate
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
has only substance units: false
initial amount: NaN
is: CHEBI:58235
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a7a8382b_3b94_4cbd_b9fe_b595024e1f04
is encoded by: hsa:7083
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P04183
is: SBO:0000252
name: TK1

metaM dttp m
type: Species
is: C00459
constant: false
is: HMDB01342
is: SBO:0000247
name: dTTP
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
has only substance units: false
is: CHEBI:37568

http://identifiers.org/biomodels.db/MODEL1310110044#_0a7a403f_9f22_4f23_9451_7f97552db818
is: SBO:0000252
is encoded by: hsa:5336
initial amount: NaN
is: P16885
initial concentration: NaN
constant: false
name: PLCG2
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_aeaa3bbe_88cd_4c2f_b3b3_72620bf85220
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:2686
has only substance units: false
initial amount: NaN
name: GGT7
initial concentration: NaN
is: A0PJJ9
boundary condition: true

metaR r0683
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110044#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR GLNtN1
reactant: MODEL1310110044#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110044#
name: Glutamine transport (Na, H coupled)
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR LEUKTRD4t
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
name: leukotriene D4 transport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_98d11dda_93ba_4d1c_8049_c9d9cb1711c5
name: COX5B
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:1329
is: Q53YB7
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR SUCCCROT
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaR C226CPT2
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is: SBO:0000176
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false
product: MODEL1310110044#
name: C226 transport into the mitochondria
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110044#

metaM 5fthf m
is: SBO:0000247
boundary condition: false
name: 5-formyltetrahydrofolate(2-)
is: HMDB01562
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: CHEBI:57457
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b1c0bc2a_3b08_46f8_883d_cdf7a9a3f8aa
is encoded by: hsa:AA526438
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: _AA526438_1_m

metaM glyc c
name: Glycerol
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
boundary condition: false
type: Species
constant: false
is: C00116
is: HMDB00131
initial concentration: 1.0

metaM tmndnccoa c
constant: false
type: Species
initial amount: NaN
is: HMDB06514
is: SBO:0000247
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
has only substance units: false
name: timnodonyl coenzyme A
initial concentration: 1.0

metaR r1983
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
reversible: false

metaM prpp e
initial concentration: 1.0
is: HMDB00280
initial amount: NaN
boundary condition: false
is: CHEBI:58017
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)

metaM lnlncg c
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
is: CHEBI:32391
is: HMDB03073

http://identifiers.org/biomodels.db/MODEL1310110044#_084bd232_bb98_44e9_b771_cd25c0cc74b1
type: Species
is encoded by: hsa:R39999
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: _R39999_1_c
is: SBO:0000252
initial amount: NaN

metaM dttp n
initial concentration: 1.0
is: CHEBI:37568
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: C00459
has only substance units: false
is: HMDB01342
name: dTTP
boundary condition: false
type: Species
constant: false

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
kinetic law: MODEL1310110044#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
type: Reaction

metaR ARGtiDF
product: MODEL1310110044#
is: SBO:0000185
name: L-arginine transport via diffusion (extracellular to cytosol)
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

metaM crn r
has only substance units: false
initial amount: NaN
is: HMDB00062
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
name: (R)-carnitine

http://identifiers.org/biomodels.db/MODEL1310110044#_535d1249_ecd0_4ccb_94e2_d3e60d84a9a5
type: Species
has only substance units: false
name: CA6
initial amount: NaN
is: Q5FC00
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:765
initial concentration: NaN

metaR r0170
fast: false
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
type: Reaction
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:

metaM HC00591 m
type: Species
name: 2-oxoglutaramate
boundary condition: false
is: CHEBI:16769
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaR RE3000M
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
name: RE3000
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_abd488b4_2510_4135_a18a_3adac6a5f2a4
is encoded by: hsa:9060
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: O95340
name: PAPSS2
is: SBO:0000252
boundary condition: true
type: Species

metaM retinol cis 11 c
is: HMDB06216
constant: false
initial concentration: 1.0
name: 11-cis-retinol
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
is: SBO:0000247

metaR ORNt4m
name: ornithine mitochondrial transport exchange with citruline
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
is: SBO:0000185
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR C226CPT1
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reversible: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reactant: MODEL1310110044#
name: carnitine C22:6 transferase
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
modifier: MODEL1310110044#

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a61f4e14_6005_402e_89c0_6c4aae9a27fc
initial amount: NaN
is: Q16836
name: HADH
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3033
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR ADK1m
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110044#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
fast: false
reversible: true
type: Reaction
name: adenylate kinase, mitochondrial
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_91b95594_7dee_4550_b31e_5c6ad76e4516
type: Species
constant: false
is: Q96CD2
is: SBO:0000252
name: PPCDC
is encoded by: hsa:60490
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_80716eae_af0a_4c51_b8f1_20dfa29364f2
type: Species
has only substance units: false
is: P82251
is: SBO:0000252
constant: false
is encoded by: hsa:11136
initial amount: NaN
boundary condition: true
name: SLC7A9
initial concentration: NaN

metaR ALAtN1
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Alanine transport (Na, H coupled)
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110044#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_4124708d_6bb8_41af_a41b_62db47af0cb4
constant: false
has only substance units: false
is encoded by: hsa:132789
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q8TDQ7
initial amount: NaN
boundary condition: true
name: GNPDA2

metaR RDH2
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
name: retinol dehydrogenase (9-cis,NADH)
type: Reaction
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT

metaR DTTPtn
name: dTTP diffusion in nucleus
reversible: true
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_dfec1ead_a53b_4d9d_aa2e_80450a5134fd
name: PANK1
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:53354
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_8f35ffca_ed4a_4801_95c6_dd3bd88d023b
is: P19440
initial concentration: NaN
name: GGT1
has only substance units: false
is encoded by: hsa:2678
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r2099
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
modifier: MODEL1310110044#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#

metaM pi n
initial concentration: 1.0
initial amount: NaN
is: CHEBI:43474
is: SBO:0000247
is: HMDB00973
type: Species
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
has only substance units: false
name: hydrogenphosphate

metaR RDH3
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
reactant: MODEL1310110044#
name: retinol dehydrogenase (11-cis,NADH)
is: SBO:0000176
modifier: MODEL1310110044#
reversible: true

metaR RBTt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
name: ribitol transport via passive diffusion
product: MODEL1310110044#

metaM ump e
has only substance units: false
initial concentration: 1.0
name: UMP(2-)
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
is: HMDB00288
is: SBO:0000247
is: CHEBI:57865
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_31ea56d9_4a97_4a56_ac30_d6e1e4ecb97d
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: P43353
has only substance units: false
name: ALDH3B1
type: Species
boundary condition: true
is encoded by: hsa:221

http://identifiers.org/biomodels.db/MODEL1310110044#_df019b4b_f1ba_43a1_84f1_0eccaddce8d7
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM pan4p m
constant: false
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01416
is: SBO:0000247
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
has only substance units: false

metaM glyc e
has only substance units: false
initial concentration: 1.0
name: Glycerol
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00131
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_32a6f3cf_ace4_4f17_87ed_b49e196a9ced
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4714
is: O95169
initial amount: NaN
name: NDUFB8
constant: false

metaM lnlncg e
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:32391
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
constant: false
name: gamma-linolenate

metaR r1902
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110044#
name: Y+LAT2 Utilized transport

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM pi m
constant: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: C00009
name: hydrogenphosphate
is: SBO:0000247
is: CHEBI:43474
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false

metaR CYTK4n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,GTP),nuclear
reversible: true
reactant: MODEL1310110044#

metaR r1981
is: SBO:0000185
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110044#
name: Y+LAT2 Utilized transport
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9b1eaacc_0931_4397_b3e6_25bb5631cec3
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P00374
is encoded by: hsa:1719
initial concentration: NaN
name: DHFR
type: Species
constant: false
boundary condition: true

metaM HC01377 m
name: S-(3-Methylbutanoyl)-dihydrolipoamide
constant: false
initial amount: NaN
type: Species
is: CHEBI:27462
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
initial concentration: 1.0

metaR FAOXC163GC142m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR MI4PP
type: Reaction
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
is described by: ECO:0000269
name: myo-inositol 4-phosphatase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_38d7d826_9a7d_41d4_a2d7_5fb2d6701e19
has only substance units: false
constant: false
type: Species
name: ALDH3B2
is encoded by: hsa:222
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P48448

metaR DNDPt59m
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110044#
name: dGTP transport via dADP antiport

http://identifiers.org/biomodels.db/MODEL1310110044#_d06678ad_96c0_4d4b_98fc_c12a2123a017
is: Q9UMR5
name: PPT2
has only substance units: false
boundary condition: true
is encoded by: hsa:9374
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR CYTK5n
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_3d1068fb_509c_46a1_a214_0c4eb6ada980
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PPA2
is: F8WDN9
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:27068

metaR FAEL183
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110044#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110044#
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_37dc8c4a_4010_4047_a629_77c411b53f98
type: Species
has only substance units: false
is encoded by: hsa:219
is: P30837
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ALDH1B1
constant: false
initial amount: NaN

metaR r2120
reversible: true
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
product: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110044#_121d6f12_8a0e_417d_905e_ccc4aa47d2b5
name: PIK3CB:PIK3R1
type: Species
is: SBO:0000297
has part: B3KT19
has part: B4DER4
initial amount: NaN
is encoded by: hsa:5291
initial concentration: NaN
is encoded by: hsa:5295
has only substance units: false
boundary condition: true
constant: false

metaR FRUt1r
fast: false
notes: GENE_ASSOCIATION: (29988.1) or (6514.1) or (155184.1) or (6518.1) or (66035.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10821868,PMID:10860996,PMID:11583593,PMID:11780753,PMID:11882499,PMID:12135767,PMID:12750891,PMID:15033637,PMID:1634504,PMID:1695905,PMID:1701966,PMID:2182619,PMID:3399500,PMID:8419132,PMID:9770484 NOTES:NCD
modifier: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
reversible: true
name: D-fructose transport in via uniport
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_c2d3e7d9_17b5_4c09_a0bf_2296c265738c
name: TALDO1
boundary condition: true
is encoded by: hsa:6888
has only substance units: false
initial concentration: NaN
constant: false
is: P37837
is: SBO:0000252
type: Species
initial amount: NaN

metaR ACETONEt2
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
reactant: MODEL1310110044#
name: acetone transport via proton symport
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000269

metaR PI45P3K
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
fast: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c00d53a3_7e02_45ca_9872_9956b1e4c4fa
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: E7EPT3
constant: false
is: SBO:0000252
name: ALDH7A1
is encoded by: hsa:501
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_4876390a_060e_494a_bea7_f5d6550c9690
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: NDUFA2
is encoded by: hsa:4695
type: Species
has only substance units: false
constant: false
is: O43678
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_8a591817_2893_49e3_b113_50667f372d1f
is: Q9Y6K8
initial amount: NaN
name: AK5
type: Species
is encoded by: hsa:26289
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM xol27oh r
constant: false
has only substance units: false
name: 26-hydroxycholesterol
initial concentration: 1.0
is: CHEBI:17703
boundary condition: false
initial amount: NaN
is: HMDB02103
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247

metaR r0399
modifier: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
fast: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110044#
reversible: true

metaM didp c
initial amount: NaN
type: Species
name: dIDP
boundary condition: false
constant: false
is: HMDB03536
is: CHEBI:28823
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaR r1754
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_fc42454c_adea_48d8_a98c_49bed9e8fdab
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2645
is: SBO:0000252
type: Species
constant: false
name: GCK
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_0195a13d_eaa7_4adb_b49b_33585aa2c18a
is: SBO:0000252
name: NMNAT1
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:64802
initial concentration: NaN
is: B1AN63
boundary condition: true

metaR 3SALATAi
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: 3-sulfino-alanine transaminase (irreversible)
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain

metaR FRDPtcr
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000134
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is: SBO:0000185
fast: false
reversible: true
type: Reaction

metaM dec24dicoa m
is: SBO:0000247
boundary condition: false
name: 2,4-decadienoylcoa
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
is: HMDB01168
constant: false
type: Species

metaR MI1345PP
kinetic law: MODEL1310110044#
reversible: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
reactant: MODEL1310110044#
is: SBO:0000176
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_a645db5c_849c_460f_afbb_e502c474e244
initial amount: NaN
is encoded by: hsa:55229
type: Species
is: Q9NVE7
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: PANK4
is: SBO:0000252

metaR PROt4 2 r
reversible: true
fast: false
is described by: ECO:0000006
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaR FAEL184
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110044#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110044#
is: SBO:0000176
name: fatty-acyl-CoA elongation (n-C20:4CoA)

metaR RE0830N
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE0830
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:

metaR r2121
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM doco13ecoa c
constant: false
has only substance units: false
boundary condition: false
name: 13-docosenoylcoa
type: Species
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892791
initial amount: NaN
initial concentration: 1.0

metaR FOLR2
reversible: false
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: folate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000254
is: SBO:0000176
type: Reaction

metaM 4hexdtetcoa m
name: 4,7,10,13-hexadecatetraenoylcoa
is: HMDB02288
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR r1602
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SPH1Pte
reversible: true
product: MODEL1310110044#
is described by: ECO:0000000
name: sph1p transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#

metaM hexe3coa m
is: SBO:0000247
boundary condition: false
is: HMDB06522
initial concentration: 1.0
constant: false
name: 3-hexenoylcoa
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_dd0766da_249d_4e4c_8be2_19b94bfc87a5
initial concentration: NaN
is encoded by: hsa:LOC727762
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _LOC727762_1_m
type: Species

metaM lnlncg r
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB03073
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
is: SBO:0000247
name: gamma-linolenate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9f295bd3_178c_442a_8309_b8f408bc47b6
name: _T83654_1_m
boundary condition: true
is encoded by: hsa:T83654
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_386ccf69_8ef7_4d5c_8c56_79a4592f93a5
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR G5SADrm
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
reversible: true

metaR DURIPP
is: SBO:0000176
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
name: deoxyuridine phosphorylase
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction
kinetic law: MODEL1310110044#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_375adc13_c0ef_43af_8612_fb1fc488d3d0
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P00918
name: CA2
type: Species
initial concentration: NaN
is encoded by: hsa:760

metaR r1088
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: Active transport

metaR URIt
is: SBO:0000185
modifier: MODEL1310110044#
is described by: ECO:0000269
product: MODEL1310110044#
reversible: true
type: Reaction
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110044#
name: uridine facilated transport in cytosol

http://identifiers.org/biomodels.db/MODEL1310110044#_72ad8871_f6f4_4f3c_b02e_155a1ab070c2
is encoded by: hsa:51703
boundary condition: true
initial concentration: NaN
name: ACSL5
is: SBO:0000252
type: Species
is: Q9ULC5
initial amount: NaN
constant: false
has only substance units: false

metaR r2122
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110044#

metaM ficytC m
is: SBO:0000247
has only substance units: false
is: CHEBI:15991
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial concentration: 1.0
name: Ferricytochrome c

metaM pro L e
has only substance units: false
is: HMDB00162
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: L-proline

metaR CO2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
name: CO2 endoplasmic reticular transport via diffusion
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR r0027
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

metaR r1603
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaR PPItm
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
type: Reaction
fast: false
is described by: ECO:0000134
reversible: true
name: diphopshate transporter, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110044#_51893314_c3c2_490a_ac80_bb960e264f9f
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:48
is: P21399
name: ACO1
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM mi4p D c
is: HMDB01313
is: SBO:0000247
constant: false
name: 1D-myo-inositol 4-phosphate(2-)
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
has only substance units: false
is: CHEBI:58469
initial amount: NaN

metaM 2hexdtetcoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
constant: false
name: 2,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
boundary condition: false
is: HMDB02288

metaR TRPt
product: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
name: L-tryptophan transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_196da847_dd0a_4e40_a517_3cdf5bbfe0a8
is: SBO:0000252
is encoded by: hsa:10861
name: SLC26A1
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR r2123
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR RE1521M
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110044#
reversible: true
name: RE1521
product: MODEL1310110044#
fast: false

metaM pmtcoa r
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
is: SBO:0000247
constant: false
is: HMDB01338
initial amount: NaN
type: Species
is: C00154
boundary condition: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false

metaM ump r
is: HMDB00288
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
is: SBO:0000247
is: CHEBI:57865
type: Species
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_792b23f9_03b4_4cff_b502_9d94a3bf37b9
type: Species
is: B4DK61
is: SBO:0000252
has only substance units: false
name: ACOX1
initial concentration: NaN
constant: false
is encoded by: hsa:51
boundary condition: true
initial amount: NaN

metaR ACCOAC
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_271b406a_33f5_4a61_b0a4_d4e0824664bf
is: SBO:0000252
has only substance units: false
is encoded by: hsa:586
is: P54687
name: BCAT1
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r1604
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_116d7dcf_fb2f_43b6_9f3b_c23b04aca4d2
constant: false
type: Species
has only substance units: false
name: PIP5K1A
initial amount: NaN
is encoded by: hsa:8394
is: Q99755
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_a4fd354a_9384_4b6f_b5c9_929582243942
is: Q96RQ3
has only substance units: false
constant: false
type: Species
boundary condition: true
name: MCCC1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56922

http://identifiers.org/biomodels.db/MODEL1310110044#_92fa4369_17a3_477e_b667_798298e98911
name: _BG035985_1_c
is encoded by: hsa:BG035985
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR 34HPPte
name: Transport of 3-(4-hydroxyphenyl)pyruvate
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_c5db8a60_ee88_4b81_98db_0ea97cff7bec
initial amount: NaN
is: O14561
name: NDUFAB1
initial concentration: NaN
type: Species
is encoded by: hsa:4706
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR FAOXC184C163m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR MTHFD
fast: false
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000134
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reversible: true

metaR r0178
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: true
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:

metaR r1605
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_c1bdc1d9_04f9_4871_98f9_4025c79d7544
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: CHAT
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1103
is: Q6LEN5

metaM hedepecoa m
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 2,4,7,10,13-hexadecapentenoylcoa
has only substance units: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: HMDB02288

metaR TYRCBOX
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
product: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110044#
name: L-Tyrosine carboxy-lyase
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_1000b617_99c0_44cf_ab56_faf712ca926d
initial amount: NaN
is: SBO:0000252
name: ADSL
constant: false
type: Species
boundary condition: true
is encoded by: hsa:158
has only substance units: false
initial concentration: NaN

metaR r2125
type: Reaction
modifier: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110044#_e402b4eb_9387_45ff_acfd_804059da5704
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:6391
name: SDHC
is: SBO:0000252
constant: false
is: Q99643
type: Species

metaR ADCim
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reversible: false
is: SBO:0000176
name: Acetoacetate decarboxylation (irreversible), mitochondrial

metaR r1010
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true

metaR FAOXC225C204m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR RETH1e
reversible: false
is described by: ECO:0000000
name: retinyl ester hydrolase (9-cis), extracellular
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
fast: false

metaR r0179
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
product: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16

metaM lnlncg l
boundary condition: false
is: HMDB03073
is: SBO:0000247
name: gamma-linolenate
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
has only substance units: false

metaR RE2998M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE2998
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
is: SBO:0000176
modifier: MODEL1310110044#

metaM pmtcoa x
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01338
is: SBO:0000247
is: C00154
type: Species
is: CHEBI:57379
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

metaR r1606
product: MODEL1310110044#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: true

metaR r0679
reactant: MODEL1310110044#
product: MODEL1310110044#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110044#

metaM 3hpp m
name: 3-hydroxypropionate
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:16510
is: HMDB00700
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_0ce4d737_f7da_456f_8fe3_49fcc49fb622
is: Q9Y2Q0
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: ATP8A1
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10396

http://identifiers.org/biomodels.db/MODEL1310110044#_1b396983_e930_433e_a7d1_bbe0a15f58e2
constant: false
initial concentration: NaN
is encoded by: hsa:2194
type: Species
boundary condition: true
is: P49327
is: SBO:0000252
name: FASN
initial amount: NaN
has only substance units: false

metaR OCDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110044#
type: Reaction
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110044#_f29e12e2_72b5_425a_8342_20ca61968c9e
is: SBO:0000297
constant: false
boundary condition: true
type: Species
name: SUCLG2:SUCLG1
has only substance units: false
has part: P53597
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8801
is encoded by: hsa:8802
has part: Q96I99

metaM ump n
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
is: CHEBI:57865
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: UMP(2-)
is: HMDB00288

http://identifiers.org/biomodels.db/MODEL1310110044#_5cdeafa4_5b7b_43d6_8319_46b875bc88c9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1607
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: DGKB

http://identifiers.org/biomodels.db/MODEL1310110044#_12c48e7a_90f5_470c_9ec2_143b3061da0c
boundary condition: true
has only substance units: false
name: G6PC
initial concentration: NaN
is: P35575
is: SBO:0000252
is encoded by: hsa:2538
constant: false
type: Species
initial amount: NaN

metaR LPS2e
name: lipase, extracellular
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
modifier: MODEL1310110044#
reversible: false
is: SBO:0000176
product: MODEL1310110044#

metaM pap c
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58343
name: adenosine 3',5'-bismonophosphate(4-)
is: HMDB00061
constant: false
initial amount: NaN
has only substance units: false

metaM nh4 x
has only substance units: false
name: Ammonium
boundary condition: false
is: CHEBI:28938
constant: false
type: Species
initial amount: NaN
is: HMDB00051
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342

metaR r1607
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is: SBO:0000185
reversible: true
reactant: MODEL1310110044#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#

metaR r2126
is: SBO:0000185
kinetic law: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
type: Reaction

metaR DHCR243r
is: SBO:0000176
kinetic law: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
fast: false
name: 24-dehydrocholesterol reductase [Precursor]
reactant: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false

metaM HC01434 x
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:58931

metaM 2dr5p c
has only substance units: false
constant: false
type: Species
is: CHEBI:57651
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)

metaM ump m
boundary condition: false
name: UMP(2-)
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: CHEBI:57865
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM clpndcoa x
is: http://identifiers.org/pubchem.compound/47205476
is: C16166
constant: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
has only substance units: false
name: clupanodonyl CoA
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB06267
boundary condition: false

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110044#
name: hydrolysis of cholesterol ester by cholesterol esterase
is version of: http://identifiers.org/ec-code/3.1.1.13
fast: false
product: MODEL1310110044#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_17d953c1_56c1_4144_8d2c_3fbde963158a
is: SBO:0000252
initial amount: NaN
constant: false
name: DDO
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8528

http://identifiers.org/biomodels.db/MODEL1310110044#_8a9a0b6b_254c_4435_b77d_1ee5098ee80d
is: SBO:0000252
is encoded by: hsa:AI345944
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: _AI345944_1_m
boundary condition: true
initial concentration: NaN

metaR MTHFC
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000134
name: methenyltetrahydrofolate cyclohydrolase
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_9f18824b_7903_4818_a5f4_f8457147b912
is: Q8WUM9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6574
constant: false
has only substance units: false
boundary condition: true
type: Species
name: SLC20A1

metaR PPItr
type: Reaction
name: Diphosphate transporter, endoplasmic reticulum
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185

metaR r2127
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_792a3eb8_8b85_4640_a6c9_5c7e7682cbbd
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q86V21
name: AACS
is encoded by: hsa:65985
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_239ab6fe_0699_48bc_b332_aaf218302b9d
boundary condition: true
name: ACSL4
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2182
initial amount: NaN
is: Q5JWV8
is: SBO:0000252
type: Species

metaR GLYtm
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
name: glycine passive transport to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR r1608
is: SBO:0000185
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110044#

metaM 4izp c
has only substance units: false
is: HMDB01014
name: 4-Imidazolone-5-propanoate
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57255
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_08320d07_db63_44db_8e03_6d4ad3324204
constant: false
is: SBO:0000252
initial concentration: NaN
name: PKLR
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5313
is: P30613
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_b568bd6d_607f_4089_9819_7df3c4d9d911
has only substance units: false
initial concentration: NaN
is: Q05C14
name: FOLR3
constant: false
is encoded by: hsa:2352
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaM HC00229 e
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Isomaltose
is: CHEBI:28189
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_bf304f06_3002_41cd_9ff4_95dbc554ebe2
initial concentration: NaN
initial amount: NaN
is: A0S0A7
has only substance units: false
type: Species
is encoded by: hsa:4846
is: SBO:0000252
name: NOS3
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fbf20982_e232_4db9_9919_ac49cc4b0a26
name: NT5C3
type: Species
initial amount: NaN
is encoded by: hsa:51251
boundary condition: true
has only substance units: false
constant: false
is: Q9H0P0
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_f052ce91_490d_4288_b25c_3d9084dfb996
constant: false
is encoded by: hsa:4513
initial concentration: NaN
name: COX2
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q7GXZ8
is: SBO:0000252

metaM CE5121 m
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: trans-3-decenoyl-CoA
boundary condition: false
is: SBO:0000247
is: CHEBI:57449
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121

metaR r2128
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_40726e42_882d_4df1_bb3d_6febe9366aad
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:224
is: SBO:0000252
boundary condition: true
name: ALDH3A2
initial concentration: NaN
is: P51648
type: Species

metaM pmtcoa m
boundary condition: false
is: HMDB01338
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
is: C00154
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
initial amount: NaN
is: CHEBI:57379
constant: false

metaR FAOXC123m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_51865e35_125c_4be5_9ee9_653ebc742b91
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1339
initial concentration: NaN
name: COX6A2
type: Species
is: Q02221
has only substance units: false

metaM ipdp x
initial amount: NaN
boundary condition: false
is: CHEBI:128769
is: HMDB01347
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: isopentenyl diphosphate(3-)
type: Species
constant: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129

metaR r0246
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is described by: ECO:0000000

metaR FORtr
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
name: FOR transporter, endoplasmic reticulum
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_324674bd_f4f7_4cfe_910b_6ec249bfc906
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: PEMT
is encoded by: hsa:10400
constant: false
initial concentration: NaN

metaR r0391
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
reversible: true
reactant: MODEL1310110044#
type: Reaction
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
kinetic law: MODEL1310110044#

metaR r0021
reactant: MODEL1310110044#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_3373230d_07c1_4ec6_9697_97d7ef867d81
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: RBAK
type: Species
is: Q9NYW8
is encoded by: hsa:57786
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_2c145efb_2ac4_4e79_a9d8_32a051b204cc
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: ATP2B4
is: SBO:0000252
is: P23634
is encoded by: hsa:493

W3 CDTF: Thu Aug 30 12:00:03 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110044#_f9ce794b_9524_48ba_bb76_2023b51a8c87
type: Species
boundary condition: true
is: Q9UHI7
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: SLC23A1
is encoded by: hsa:9963

metaM udpg c
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: UDPglucose
initial concentration: 1.0
constant: false
is: CHEBI:58367
is: C00029
type: Species
is: HMDB00286
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaR PPItx
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
name: Diphosphate transporter, peroxisome
is described by: ECO:0000000

metaR r2129
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_a8530a31_264b_4ffe_bba3_c09c8facb916
name: PPCS
is: Q9HAB8
type: Species
is encoded by: hsa:79717
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR ADKd
modifier: MODEL1310110044#
name: adenylate kinase (d form)
reactant: MODEL1310110044#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR r1544
type: Reaction
fast: false
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_5ef95e95_b596_4187_a3fc_c93e6d876434
is encoded by: hsa:7296
has only substance units: false
type: Species
name: TXNRD1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR r0245
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_609b758f_d2c2_467f_9f72_21cff3141456
initial amount: NaN
is: P31939
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:471
name: ATIC
type: Species
constant: false

metaR DASCBR
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
reversible: false
modifier: MODEL1310110044#
name: dehydroascorbate reductase
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_ea5a0348_16ee_4b3b_823b_b39d2a112b7a
type: Species
is encoded by: hsa:6575
initial amount: NaN
is: SBO:0000252
is: B2RBR4
boundary condition: true
has only substance units: false
name: SLC20A2
initial concentration: NaN
constant: false

metaM rbt c
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00508
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: D-ribitol
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: CHEBI:15963

metaR r0022
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
fast: false
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaM 4hpro LT m
boundary condition: false
initial amount: NaN
is: HMDB00725
is: CHEBI:18095
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
constant: false
type: Species
name: trans-4-hydroxy-L-proline
is: SBO:0000247

W3 CDTF: Thu Aug 30 12:00:03 BST 2012

metaR FAOXC226C225m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR r0390
product: MODEL1310110044#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_3306a7f2_8d5d_40d3_b3be_b7988e08bf92
name: AK2
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:204
has only substance units: false

metaM dectricoa m
has only substance units: false
type: Species
boundary condition: false
name: 2,4,7-decatrienoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247

metaR NDPK8n
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
modifier: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_0acbdf8b_81ac_4cfa_8142_82c2ff8ed9c2
name: PLCG1
is: SBO:0000252
is encoded by: hsa:5335
constant: false
boundary condition: true
type: Species
is: Q9UFY1
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r1547
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR PROSTGH2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
fast: false
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true

metaR r1019
fast: false
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true

metaR PGDI
is described by: ECO:0000269
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
name: Prostaglandin-H2 D-isomerase [Precursor]
product: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.2
kinetic law: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
is: SBO:0000176

metaR RE0830C
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
name: RE0830
product: MODEL1310110044#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110044#

metaR r0393
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_825653f3_8018_4f31_b0a3_1bcf39e729f9
boundary condition: true
is encoded by: hsa:51727
type: Species
name: CMPK1
constant: false
initial amount: NaN
is: SBO:0000252
is: B2R6S5
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_766b107c_dd5b_4673_8fbe_4507d4c4dea0
constant: false
has only substance units: false
name: BDH1
is: SBO:0000252
initial concentration: NaN
is: Q02338
is encoded by: hsa:622
boundary condition: true
type: Species
initial amount: NaN

metaR P5CRxm
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
name: pyrroline-5-carboxylate reductase (m)
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_e1441b59_d5a2_4dc3_8a26_386eb5261f4d
boundary condition: true
initial amount: NaN
is encoded by: hsa:54963
name: UCKL1
constant: false
is: SBO:0000252
is: Q53HM1
has only substance units: false
type: Species
initial concentration: NaN

W3 CDTF: Thu Aug 30 12:00:03 BST 2012

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR DNDPt35m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dADP antiport
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
reversible: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000269

metaM trdrd c
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
boundary condition: false
is: CHEBI:15967
is: SBO:0000247
is: C00342
type: Species
initial amount: NaN
has only substance units: false
name: Reduced thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110044#_66c2d6eb_f6f7_4823_b464_cabb1e47ef0c
constant: false
has only substance units: false
is encoded by: hsa:5289
name: PIK3C3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q8NEB9
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_739b633f_f863_4008_831c_e536ef4f5aae
boundary condition: true
is encoded by: hsa:23169
constant: false
name: SLC35D1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9NTN3
type: Species

metaR RE1903R
reversible: true
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is described by: ECO:0000000
name: RE1903

metaR DTDPtn
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
name: dTDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_6aa95b45_57d3_48e5_ac3c_f3095e0b7ff4
initial amount: NaN
name: _AI926493_1_c
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI926493

metaR LNLCt
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110044#
type: Reaction
name: Linoleic acid (n-C18:2) transport in via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR r1546
type: Reaction
reactant: MODEL1310110044#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR MI14PP
name: inositol-1,4-bisphosphate 1-phosphatase
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.57
fast: false
type: Reaction
is: SBO:0000176

metaR r0392
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
reversible: true
type: Reaction

W3 CDTF: Thu Aug 30 12:00:03 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110044#_6db65491_0626_4236_8d22_9c53f7ecf086
initial amount: NaN
is: SBO:0000252
is: Q6PCB7
constant: false
name: SLC27A1
is encoded by: hsa:376497
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaR LNLNCAt
reactant: MODEL1310110044#
name: fatty acid transport via diffusion
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaM 2obut c
is: CHEBI:16763
is: HMDB00005
boundary condition: false
is: SBO:0000247
is: C00109
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-Oxobutanoate
has only substance units: false
initial amount: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR CMPSAS
modifier: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase
is version of: http://identifiers.org/ec-code/2.7.7.43
product: MODEL1310110044#
fast: false

metaM mi13p c
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06234
is: CHEBI:18225
boundary condition: false
type: Species
name: 1D-myo-Inositol 1,3-bisphosphate
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: SBO:0000247

metaM his L m
is: CHEBI:15971
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
boundary condition: false
is: HMDB00177
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaM nmn c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00229
is: CHEBI:14649
name: NMN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: C00455

http://identifiers.org/biomodels.db/MODEL1310110044#_f85982ff_0a2d_4a90_b16f_73fa5f1f820a
is: SBO:0000252
is: P17752
constant: false
has only substance units: false
initial amount: NaN
name: TPH1
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:7166

metaR r1549
kinetic law: MODEL1310110044#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_4f2193a5_552b_4ecd_8518_656dee412cb3
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4830
initial amount: NaN
boundary condition: true
name: NME1
initial concentration: NaN
is: SBO:0000252
is: P15531

metaM 5aop m
name: 5-Amino-4-oxopentanoate
is: CHEBI:17549
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00430
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: HMDB01149
type: Species

metaM pro L c
is: CHEBI:17203
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00162
initial amount: NaN
name: L-proline
type: Species
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaM pglyc hs e
name: phosphatidylglycerol(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: SBO:0000247
type: Species
is: CHEBI:60523

metaR NAIt
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
reactant: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000269
fast: false
type: Reaction
name: Na+ / iodide cotransport

metaR NOt
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
name: NO transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110044#_c26fd97c_8ec2_4e89_b98d_5bb7a614b981
type: Species
initial amount: NaN
name: _AV717590_1_m
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AV717590
has only substance units: false

metaR r0242
is described by: ECO:0000000
product: MODEL1310110044#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_324ead5b_2208_48b3_ae0c_350f3d6db087
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI935189_1_m
is encoded by: hsa:AI935189
has only substance units: false

metaM gthrd r
name: glutathionate(1-)
constant: false
is: CHEBI:57925
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00125
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaR ANTHte
kinetic law: MODEL1310110044#
name: Transport of anthranilate
is described by: ECO:0000134
fast: false
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110044#

metaR r0395
fast: false
reactant: MODEL1310110044#
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:

metaM 3pg m
is: HMDB00807
type: Species
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
boundary condition: false
is: CHEBI:58272
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_cc1c5f19_933d_4719_99a1_7097a6821f3d
name: _AI435857_1_x
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI435857

metaR H2Oter
is: SBO:0000185
product: MODEL1310110044#
name: H2O endoplasmic reticulum transport
reactant: MODEL1310110044#
fast: false
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaM 2oxoadp c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00225
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
is: CHEBI:57499
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_9e01b39e_0fa4_4cc1_bbf0_9d9d91d6fd99
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:55902
is: Q5QPH3
name: ACSS2
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r1018
fast: false
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true

metaR r1548
product: MODEL1310110044#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_518a4f79_5555_4259_8c0f_d17f950bfa64
constant: false
type: Species
is: SBO:0000252
name: SLC6A2
has only substance units: false
is encoded by: hsa:6530
is: Q96KH8
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_11e39c8b_fbf1_47e0_8cae_fabb86d5f9df
is encoded by: hsa:1503
initial concentration: NaN
is: P17812
initial amount: NaN
name: CTPS1
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_8463f2a3_2e9b_483c_9e47_caf6f54e29ee
constant: false
initial concentration: NaN
is: SBO:0000252
name: RDH10
initial amount: NaN
is encoded by: hsa:157506
type: Species
boundary condition: true
has only substance units: false
is: Q8IZV5

http://identifiers.org/biomodels.db/MODEL1310110044#_c758ab11_cd0f_442c_bd35_b017a66867e9
type: Species
name: IDH2
initial amount: NaN
is: P48735
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3418

metaR PSt3
product: MODEL1310110044#
name: phosphatidylserine transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e55c7c6e_7b86_4292_a905_1d11c4d39f43
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: _AI620219_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI620219

http://identifiers.org/biomodels.db/MODEL1310110044#_695b939a_616b_4765_999d_bd0d561a6c3d
name: NDUFA3
is: SBO:0000252
has only substance units: false
is: O95167
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4696
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_d594b3de_79eb_40ad_9906_f876b7b66699
is: A8K0S7
is encoded by: hsa:2542
name: SLC37A4
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR MDHm
reversible: true
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
name: malate dehydrogenase, mitochondrial

metaR RBFK
is version of: http://identifiers.org/ec-code/2.7.1.26
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
name: riboflavin kinase
type: Reaction
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#

metaR r0394
reactant: MODEL1310110044#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
is: SBO:0000176
reversible: true
type: Reaction
fast: false

metaM HC01405 m
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
name: (S)-Hydroxyoctanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28632
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_6d84b8e9_ed30_4f94_8300_d087c3a49983
constant: false
initial concentration: NaN
is: Q16831
initial amount: NaN
is encoded by: hsa:7378
name: UPP1
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR 34DHXMANDACOX
product: MODEL1310110044#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_9a759507_3601_46c9_ac9b_2443cc47bc4f
constant: false
has only substance units: false
boundary condition: true
name: AK4
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: P27144
is encoded by: hsa:205

metaM didp n
name: dIDP
boundary condition: false
is: HMDB03536
is: SBO:0000247
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaM pglyc hs c
is: CHEBI:60523
constant: false
name: phosphatidylglycerol(1-)
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaM 3mgcoa m
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB01057
initial concentration: 1.0
is: CHEBI:57346
is: SBO:0000247
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
name: trans-3-methylglutaconyl-CoA(5-)
has only substance units: false

metaR r1600
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM arachdcoa x
is: HMDB06523
is: SBO:0000247
name: arachidonoyl-CoA(4-)
boundary condition: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57368
constant: false

metaR RE0958E
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110044#
fast: false
is: SBO:0000176
name: RE0958
type: Reaction

metaR PROt2r
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
name: L-proline reversible transport via proton symport
fast: false
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185

metaR SO4HCOtex
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110044#
reversible: false
name: sulfate transport via bicarbonate countertransport
reactant: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
is: SBO:0000185
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_c6977897_2a7e_43a4_9253_71b2af95c264
is: SBO:0000252
type: Species
is encoded by: hsa:AI761708
name: _AI761708_1_m
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaR RE1518M
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1518
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110044#
is: SBO:0000176
modifier: MODEL1310110044#

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM docohepcoa m
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16,19-docosaheptenoylcoa

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB00051
has only substance units: false
name: ammonium
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_92edf581_f739_431c_b022_304c01b01cb1
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _AI024818_1_c
is encoded by: hsa:AI024818
boundary condition: true
constant: false
initial concentration: NaN

metaM C05279 m
initial concentration: 1.0
has only substance units: false
is: CHEBI:28387
initial amount: NaN
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
is: HMDB11123
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
boundary condition: false
constant: false

metaR EX 13 cis retnglc LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 13-cis-retinoyl glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d1756fb6_847a_48de_8936_b66d523b4fcf
is: P14324
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: FDPS
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2224
type: Species

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: CHEBI:29101
constant: false
name: sodium(1+)
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00588
initial concentration: 1.0

metaM bilglcur e
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
is: CHEBI:57767
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaR PRAGSr
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
name: phosphoribosylglycinamide synthase
is version of: http://identifiers.org/ec-code/2.1.2.2
kinetic law: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_30cd3e8c_9fec_4bfe_af5a_492791fef12d
is: SBO:0000252
initial amount: NaN
name: SHMT2
initial concentration: NaN
boundary condition: true
is: B4DJQ3
constant: false
has only substance units: false
is encoded by: hsa:6472
type: Species

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM leu L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
boundary condition: false
has only substance units: false
is: HMDB00687
initial concentration: 1.0
constant: false
is: SBO:0000247
name: L-leucine
type: Species
initial amount: NaN

metaR r1640
fast: false
kinetic law: MODEL1310110044#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#

metaM but c
boundary condition: false
name: butyrate
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial concentration: 1.0
is: HMDB00039
has only substance units: false
is: SBO:0000247
is: CHEBI:17968

metaM gar c
initial amount: NaN
is: CHEBI:58457
is: C03838
is: HMDB02022
boundary condition: false
has only substance units: false
name: N1-(5-Phospho-D-ribosyl)glycinamide
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838

metaR RE2972M
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
fast: false
modifier: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110044#
is described by: ECO:0000000
name: RE2972
type: Reaction

metaM mal L m
name: (S)-malate(2-)
is: HMDB00156
boundary condition: false
is: CHEBI:15589
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_e375b028_818a_42cb_8333_99e8e7683a1d
is: P55084
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:3032
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: HADHB

http://identifiers.org/biomodels.db/MODEL1310110044#_f5c9573d_ddd7_477b_ae30_304340517d09
is: H7C5B8
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4708
boundary condition: true
is: SBO:0000252
name: NDUFB2

metaR r0899
reversible: true
type: Reaction
product: MODEL1310110044#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110044#
is described by: ECO:0000000

metaM h m
constant: false
has only substance units: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
type: Species
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: proton

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110044#
type: Reaction
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000176
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#

metaM 2oxoadp m
is: CHEBI:57499
type: Species
is: HMDB00225
initial concentration: 1.0
name: 2-oxoadipate(2-)
boundary condition: false
constant: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR PROD2m
name: Proline dehydrogenase (m)
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000254
reversible: false
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR MGSA2
product: MODEL1310110044#
reversible: false
name: methyglyoxylate synthase 2 (from g3p)
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD

metaM bilglcur c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR CYTK12n
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110044#
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110044#

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR RE2626M
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: RE2626
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110044#

metaR r1377
fast: false
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true

metaM h n
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
is: CHEBI:24636
type: Species
initial amount: NaN
name: proton
constant: false
initial concentration: 1.0

metaM but e
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial amount: NaN
has only substance units: false
is: HMDB00039
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: butyrate
is: SBO:0000247

metaR P5CR
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
is described by: ECO:0000134
name: pyrroline-5-carboxylate reductase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_633b50dc_317d_409d_be56_e094648d530a
has only substance units: false
constant: false
is: Q9UIG8
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: SLCO3A1
is encoded by: hsa:28232

http://identifiers.org/biomodels.db/MODEL1310110044#_5d5e602f_213f_4ac0_b1d0_f79eeb3f0a26
initial amount: NaN
name: UCP3
is encoded by: hsa:7352
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaR r0591
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_06dcae6f_43c6_4dc8_8d53_93c85e708398
initial amount: NaN
is: P42126
constant: false
is encoded by: hsa:1632
is: SBO:0000252
name: ECI1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_fc7fdd31_92fd_4912_89e7_b5c4db959ff7
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: NDUFB9
is encoded by: hsa:4715
is: Q9Y6M9
boundary condition: true
type: Species

metaR GLUTCOADHm
is version of: http://identifiers.org/ec-code/1.3.99.7
name: glutaryl-CoA dehydrogenase (mitochondria)
modifier: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
kinetic law: MODEL1310110044#
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_7d3098a2_ced2_498d_ae26_f9ba2ca4b6cf
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:51733
name: UPB1
boundary condition: true
is: B3KNC1
constant: false
has only substance units: false

metaM occoa x
is: HMDB01070
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: C01944
has only substance units: false
boundary condition: false
is: CHEBI:57386
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)

metaM ptrc c
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial amount: NaN
name: Putrescine
is: C00134
type: Species
has only substance units: false
is: HMDB01414
is: SBO:0000247
constant: false
is: CHEBI:326268
boundary condition: false
initial concentration: 1.0

metaR r0590
is: SBO:0000176
fast: false
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110044#
reversible: false
type: Reaction

metaM thbpt c
initial amount: NaN
constant: false
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
has only substance units: false
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: HMDB00027
is: SBO:0000247
type: Species

metaM na1 e
is: C01330
is: CHEBI:4541
initial amount: NaN
has only substance units: false
name: Sodium
notes: FORMULA: Na CHARGE: 1
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00588
constant: false

metaM 3decdicoa m
name: 3,7-decadienoylcoa
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_747df9e1_1f51_4f88_b577_e3b38640f36e
is: Q9H2F3
boundary condition: true
type: Species
name: HSD3B7
initial amount: NaN
is encoded by: hsa:80270
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM dhf e
initial amount: NaN
name: dihydrofolate(2-)
is: CHEBI:57451
constant: false
type: Species
initial concentration: 1.0
is: HMDB01056
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR r0488
fast: false
product: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true

metaM sph1p e
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
has only substance units: false
is: CHEBI:57939
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01383
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_27530036_b290_4aa8_8fd4_0e93b14b0fa6
constant: false
is: Q92911
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC5A5
has only substance units: false
is encoded by: hsa:6528
initial amount: NaN
boundary condition: true

metaM HC02206 e
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
boundary condition: false
name: prostaglandin C1(1-)
initial amount: NaN
is: CHEBI:57399

http://identifiers.org/biomodels.db/MODEL1310110044#_eabc845f_4cdc_4f6c_8bad_06acb6fac235
is encoded by: hsa:249
has only substance units: false
is: SBO:0000252
name: ALPL
initial amount: NaN
boundary condition: true
is: B7Z4Y6
type: Species
initial concentration: NaN
constant: false

metaM 4mop m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: 4-methyl-2-oxopentanoate
is: HMDB00695
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
constant: false
is: SBO:0000247

metaR r1957
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185

metaM orot5p c
is: C01103
has only substance units: false
initial concentration: 1.0
name: Orotidine 5'-phosphate
is: SBO:0000247
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
initial amount: NaN
boundary condition: false
is: CHEBI:57538
type: Species
is: HMDB00218
constant: false

metaR NDPK4n
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is: SBO:0000176
reversible: true
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_7657aac6_b8d7_45c7_8acc_18e058e432dd
is encoded by: hsa:6580
is: SBO:0000252
name: SLC22A1
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: O15245

metaM adp x
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: ADP(3-)
constant: false
initial amount: NaN
is: CHEBI:456216

metaR FAOXC102C101m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR HPACtr
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
name: hydroxyphenylacetate transport via diffusion
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction
is described by: ECO:0000000

metaM ptrc e
initial concentration: 1.0
name: Putrescine
is: C00134
constant: false
is: HMDB01414
is: CHEBI:326268
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaM pmtcoa c
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
constant: false
is: CHEBI:3454
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00154
is: HMDB01338
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110044#

metaM pectingchol e
boundary condition: false
is: HMDB03402
constant: false
type: Species
name: pectin-glycocholate complex
has only substance units: false
notes: FORMULA: C2561H3553NO2541 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_2627b9a6_84f7_4eb8_b98d_3c87115a46f5
is encoded by: hsa:204
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: P54819
name: AK2
initial amount: NaN
initial concentration: NaN

metaM na1 c
constant: false
has only substance units: false
is: C01330
is: CHEBI:4541
name: Sodium
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00588

metaR MI134P4P
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
product: MODEL1310110044#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110044#
name: inositol-1,3,4-trisphosphate 4-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110044#_0d6857ab_8718_430e_8b7e_4a536037ed1c
type: Species
initial amount: NaN
is: O43252
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:9061
name: PAPSS1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_c1838600_1583_4580_8ff5_3de058655330
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:124
name: ADH1A
boundary condition: true
constant: false
is: P07327

http://identifiers.org/biomodels.db/MODEL1310110044#_c6ffe64d_4aa6_45ac_8f2f_5d23e14926fb
has only substance units: false
initial amount: NaN
name: HK1
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3098
is: Q59FD4
initial concentration: NaN
constant: false

metaM mercplaccys e
is: HMDB06512
name: 3-mercaptolactate-cysteine disulfide
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaM dec47dicoa m
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 4,7-decadienoylcoa
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_69e036f1_be73_4266_8bd2_f0e7435e1bff
boundary condition: true
name: LDHD
is: SBO:0000252
is encoded by: hsa:197257
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM dhf c
initial amount: NaN
is: C00415
is: CHEBI:57451
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
constant: false
has only substance units: false
name: 7,8-Dihydrofolate
boundary condition: false
is: HMDB01056
is: SBO:0000247

metaM glyc3p c
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57597
is: HMDB00126
has only substance units: false
is: C00093
name: Glycerol 3-phosphate

http://identifiers.org/biomodels.db/MODEL1310110044#_8aab640d_dd26_465b_95ee_ac69278ef7f6
type: Species
has only substance units: false
constant: false
name: SLC25A21
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:89874
is: G3V4L5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_6f86ecb3_7b26_476b_a4bd_df49897885fd
constant: false
is encoded by: hsa:56953
type: Species
initial amount: NaN
has only substance units: false
is: Q9NPB1
is: SBO:0000252
name: NT5M
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_f5c46fa4_2c06_4961_b634_84277ccd75cf
constant: false
is: Q16760
is: SBO:0000252
is encoded by: hsa:8527
initial amount: NaN
name: DGKD
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_b96c3b7a_bfb5_40df_82cf_e4ba0af30a8f
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:H77542
name: _H77542_1_c
boundary condition: true
is: SBO:0000252

metaM mi1p D c
initial concentration: 1.0
is: HMDB02985
is: CHEBI:58433
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_330468e0_521a_4bb6_a6ff_9d5252d91250
is: Q15392
is encoded by: hsa:1718
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DHCR24
initial concentration: NaN
type: Species
boundary condition: true

metaR SQLSr
modifier: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110044#
is: SBO:0000176
reversible: false
name: Squalene synthase
reactant: MODEL1310110044#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false

metaR C4STMO2Pr
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
kinetic law: MODEL1310110044#
name: C-4 methyl sterol oxidase
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR DHFtm
type: Reaction
name: dihydrofolate reversible mitochondrial transport
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_6511b7c0_58c4_4e65_857a_e14c5cc96468
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:25769
boundary condition: true
initial concentration: NaN
is: Q9UI40
name: SLC24A2
type: Species

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c3752dd8_7845_4d21_a7b2_3bf5fe997a97
is encoded by: hsa:4725
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q6IBA0
name: NDUFS5
has only substance units: false

metaR ASCBt
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: L-ascorbate transport via facilitated diffusion
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
fast: false

metaR SUCCOAPET
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM retinal c
is: HMDB01358
has only substance units: false
initial amount: NaN
name: retinal
type: Species
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: SBO:0000247
is: CHEBI:15035
initial concentration: 1.0
constant: false

metaM CE4792 m
is: CHEBI:57923
type: Species
boundary condition: false
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaR PI5P4K
name: phosphatidylinositol-5-phosphate 4-kinase
fast: false
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.67
reactant: MODEL1310110044#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD

metaM retinal 11 cis c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16066
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: HMDB02152
type: Species
name: 11-cis-retinal
is: SBO:0000247
constant: false
has only substance units: false

metaM man6p c
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:17369
is: SBO:0000247
name: D-Mannose 6-phosphate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: HMDB01078

metaR FACOAL80i
reactant: MODEL1310110044#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
type: Reaction
name: fatty-acid--CoA ligase (octanoate)
is described by: ECO:0000269

metaR RE3626M
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
reversible: false
name: RE3626
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#

metaM arachd e
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: arachidonate
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043
is: CHEBI:32395
has only substance units: false
boundary condition: false

metaR r1847
modifier: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110044#

metaM mercplaccys c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: HMDB06512
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide

metaR r0604
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is: SBO:0000176
modifier: MODEL1310110044#

metaR DCMPDA
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.12
product: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
name: dCMP deaminase
type: Reaction
reversible: true
kinetic law: MODEL1310110044#

metaR r0892
is described by: ECO:0000000
name: Facilitated diffusion
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.27
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR r2534
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR FAOXC122C101m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_7fb89196_9d4f_435d_ae9a_51e6f6a63d6c
has only substance units: false
is encoded by: hsa:AA664770
name: _AA664770_1_m
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaM hco3 e
is: HMDB00595
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
is: CHEBI:17544
is: C00288
name: Bicarbonate
is: SBO:0000247
constant: false
has only substance units: false

metaR r0596
reactant: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
modifier: MODEL1310110044#
type: Reaction
reversible: false

metaR MMTSADm
reactant: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000000

metaM HC00361 c
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
is: CHEBI:58335
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
is: SBO:0000247

metaR MTHFD2m
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
fast: false
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reactant: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_513002ce_3cb0_4d92_9b48_205fc0472c46
is: Q9NVS9
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PNPO
type: Species
constant: false
boundary condition: true
is encoded by: hsa:55163
is: SBO:0000252

metaM sbt D e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
constant: false
has only substance units: false
name: D-glucitol
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00247

metaM r5p c
is: CHEBI:18189
type: Species
is: SBO:0000247
boundary condition: false
is: C00117
constant: false
is: HMDB00618
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false
initial concentration: 1.0

metaR LEUt5m
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
name: leucine mitochondrial transport
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
reactant: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.12
is described by: ECO:0000000
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_0f1f5037_5485_40dd_960c_dacf046bf655
initial concentration: NaN
has only substance units: false
is encoded by: hsa:257202
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: GPX6
boundary condition: true
is: P59796

metaR FAOXC164GC163m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM acetone m
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
name: acetone
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:15347

metaR r2535
type: Reaction
fast: false
product: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2532
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110044#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
is described by: ECO:0000000

metaR ACACT7p
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
product: MODEL1310110044#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110044#
is described by: ECO:0000269

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_40c1f6d1_24d0_4863_9663_91d03756f49c
constant: false
boundary condition: true
name: _FLJ44968_1_m
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:FLJ44968

metaR 3HLYTCL
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
product: MODEL1310110044#
name: 3-Hydroxy-L-tyrosine carboxy-lyase
modifier: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.1.1.28

metaM sph1p c
type: Species
has only substance units: false
is: HMDB01383
is: CHEBI:57939
is: SBO:0000247
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120

http://identifiers.org/biomodels.db/MODEL1310110044#_af98a31b_480b_49a4_83ff_612abb3e1065
is encoded by: hsa:107
constant: false
has only substance units: false
boundary condition: true
is: Q08828
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: ADCY1

metaR PI4P3K
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
name: phosphatidylinositol 4-phosphate 3-kinase

metaR LNLCCPT2
type: Reaction
reactant: MODEL1310110044#
reversible: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false
is described by: ECO:0000000

metaR r0812
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
has only substance units: false
is: CHEBI:28910
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_b1567912_0b78_4506_ad74_4d4b0c55e518
is encoded by: hsa:2731
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: P23378
name: GLDC
boundary condition: true
has only substance units: false

metaR CYTK3n
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110044#
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110044#

metaR SUCD1m
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reactant: MODEL1310110044#
name: succinate dehydrogenase
product: MODEL1310110044#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_074297f7_d83b_4346_bcb7_45fc3ae14ce4
type: Species
name: HADHA
boundary condition: true
constant: false
is encoded by: hsa:3030
is: E9KL44
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_9a4809e2_456c_4925_bc8f_d1d1ab56f6a1
initial concentration: NaN
is encoded by: hsa:83549
has only substance units: false
is: Q5JT09
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: UCK1
is: SBO:0000252

metaM CE2434 m
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
is: CHEBI:57795

metaM sbt D c
is: SBO:0000247
is: HMDB00247
boundary condition: false
is: CHEBI:17924
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
name: D-glucitol
constant: false
type: Species
initial amount: NaN

metaM pacald c
constant: false
name: phenylacetaldehyde
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16424
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: HMDB06236

metaM zymstnl r
initial amount: NaN
has only substance units: false
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: CHEBI:16608
boundary condition: false
constant: false
is: HMDB06841

metaR NH4t3r
modifier: MODEL1310110044#
name: ammonia transport via proton antiport
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
fast: false

metaM retinal cis 9 c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
type: Species
is: HMDB01358
is: SBO:0000247
is: CHEBI:17898
constant: false
name: all-trans-retinal
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR ITCOAL1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR r0817
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110044#
reversible: true
fast: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR r0480
type: Reaction
fast: false
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true

metaR P5CDm
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
reversible: false
fast: false
reactant: MODEL1310110044#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
kinetic law: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110044#_bdc415f9_4a38_46cb_9688_243a3bd93013
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:84693
name: MCEE
is: Q96PE7
is: SBO:0000252
type: Species
initial concentration: NaN

metaR CO2t
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reactant: MODEL1310110044#
name: CO2 transporter via diffusion
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
type: Reaction

metaR 3HBCOAHLm
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
fast: false
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
product: MODEL1310110044#
reversible: false

metaM 3snpyr c
is: CHEBI:1665
is: HMDB02332
name: 3-Sulfinopyruvate
type: Species
is: SBO:0000247
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_e3477244_35e7_4d8e_bee4_5b0a3f02ccc9
initial amount: NaN
is encoded by: hsa:8560
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: DEGS1
has only substance units: false

metaR r1843
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
modifier: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_c4ab8dad_c906_4914_854e_4598e8fb9eb4
is encoded by: hsa:285973
initial amount: NaN
is: Q674R7
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ATG9B
is: SBO:0000252
constant: false
type: Species

metaM 3pg c
type: Species
is: http://identifiers.org/pubchem.compound/3497
name: 3-Phospho-D-glycerate
is: C00197
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58272
boundary condition: false
is: HMDB00807
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_f486384d_ba65_4f31_a46b_51f5accb5b69
initial amount: NaN
is encoded by: hsa:221823
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: PRPS1L1

metaM HC01403 m
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
constant: false

metaR ATPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ATP diffusion in nucleus
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#

metaM glyc R c
constant: false
is: SBO:0000247
type: Species
name: D-glycerate
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00139
is: CHEBI:16659

metaR r1378
type: Reaction
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
fast: false
reversible: true
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
kinetic law: MODEL1310110044#
is: SBO:0000176

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM ttdca e
initial amount: NaN
type: Species
name: tetradecanoate (n-C14:0)
initial concentration: 1.0
is: CHEBI:30807
has only substance units: false
is: C06424
is: HMDB00806
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
boundary condition: false
is: SBO:0000247

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
reactant: MODEL1310110044#

metaR CHOLtg
product: MODEL1310110044#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
reactant: MODEL1310110044#
name: choline intracellular transport
kinetic law: MODEL1310110044#

metaR r0595
is: SBO:0000176
product: MODEL1310110044#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
reversible: false
type: Reaction
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2

metaR RE3272N
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE3272
product: MODEL1310110044#

metaM arachd c
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: arachidonate
is: HMDB01043
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32395
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_b6d764d6_3505_4eac_83ae_861bf5b79c62
type: Species
has only substance units: false
constant: false
boundary condition: true
name: _AI656480_1_m
initial concentration: NaN
is encoded by: hsa:AI656480
is: SBO:0000252
initial amount: NaN

metaR ECOAH9m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
type: Reaction
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
fast: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR AIRCr
fast: false
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.3.2.6
type: Reaction
product: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylaminoimidazole carboxylase
is: SBO:0000176

metaM h r
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00080
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial amount: NaN
is: CHEBI:24636

metaM adp m
initial concentration: 1.0
name: ADP
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01341
is: CHEBI:456216
constant: false
is: SBO:0000247
is: C00008
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310

metaR RE3524R
name: RE3524
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a9d7c9dc_b025_47db_9931_5d318ed7da67
initial concentration: NaN
name: IDI1
constant: false
initial amount: NaN
is: Q13907
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3422

metaR BHBtm
fast: false
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
kinetic law: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185

metaM hco3 c
name: Bicarbonate
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17544
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
boundary condition: false
initial concentration: 1.0
is: C00288

metaR INSTt4
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110044#
name: inositol transport via sodium symport
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR r0594
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
kinetic law: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110044#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e3eea9a5_791e_40e6_9261_f00cc64c9a23
is: SBO:0000252
initial amount: NaN
type: Species
is: Q0VAA5
has only substance units: false
is encoded by: hsa:257068
boundary condition: true
name: PLCXD2
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_d73ee033_21f7_4f8f_9c33_6f64499fb4f9
constant: false
name: _AI620219_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI620219
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM adp n
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
type: Species
is: CHEBI:456216
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: ADP(3-)

metaM mal L x
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00156
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_e884e4f9_728c_4701_a919_a363ca28b9e8
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: G6PC2
type: Species
is encoded by: hsa:57818
initial amount: NaN
constant: false
is: E9PAX2

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
name: suberylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM hco3 m
is: HMDB00595
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
constant: false
name: Bicarbonate
boundary condition: false
has only substance units: false
is: C00288
is: SBO:0000247
is: CHEBI:17544
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_6851556e_b31d_4e5a_a893_cba241e3960f
type: Species
is encoded by: hsa:81539
is: SBO:0000252
name: SLC38A1
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: Q9H2H9
initial concentration: NaN

metaR D3AIBTm
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_475a440d_e7ae_4ed2_adea_eb4a106bc975
type: Species
is: P36269
name: GGT5
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2687
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM pail45p hs n
type: Species
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
initial concentration: 1.0
constant: false

metaR RE0944E
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
modifier: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
name: RE0944
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_fc8f1371_0838_4572_89c8_f7636d485bd8
type: Species
name: ENPP1
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P22413
is encoded by: hsa:5167

http://identifiers.org/biomodels.db/MODEL1310110044#_a2143dd4_974a_44ce_be08_bc9bd84964c1
has only substance units: false
is: SBO:0000252
name: PRDX3
boundary condition: true
type: Species
is: P30048
is encoded by: hsa:10935
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2193
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110044#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000

metaR RE3003M
fast: false
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
name: RE3003
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110044#_f07f4923_9adc_43db_99e4_8a3eeddae161
constant: false
has only substance units: false
is encoded by: hsa:4830
type: Species
name: NME1:NME2
is: SBO:0000297
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_14953d76_cb8f_4701_b936_12b91d6df695
name: FOLR1
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaM duri e
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00012
is: C00526
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
type: Species
boundary condition: false

metaR DNDPt40m
is: SBO:0000185
reversible: false
name: dUTP transport via dADP antiport
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110044#

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
is: CHEBI:28607
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: CoproporphyrinogenI
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM prostgf2 e
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false
type: Species
initial amount: NaN
is: HMDB01139
has only substance units: false
is: SBO:0000247
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
boundary condition: false

metaR r2114
modifier: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#

metaR r2115
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_28ca84fe_76f9_4b26_8e19_d5567a6c9afc
type: Species
initial concentration: NaN
name: DHCR24
is encoded by: hsa:1718
is: Q15392
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

metaR ICDHy
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
is described by: ECO:0000269
reversible: false
name: isocitrate dehydrogenase (NADP)
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#

metaM 4hexdtricoa m
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 4,7,10-hexadecatrienoylcoa
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02288
has only substance units: false
type: Species

metaR HMGCOASi
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
type: Reaction
fast: false
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)

metaM dctp n
initial amount: NaN
is: CHEBI:16311
is: C00458
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
has only substance units: false
name: dCTP
is: HMDB00998
is: SBO:0000247
type: Species
boundary condition: false

metaR MAL Ltx
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000134
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Transport reaction for malate
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.

http://identifiers.org/biomodels.db/MODEL1310110044#_b6effac9_b3a6_47e3_89a0_37e70a0bba0a
name: PI4KB
is: Q9UBF8
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5298
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_1e0455cd_30f1_4fd9_9c4c_bdd0eb678263
boundary condition: true
is encoded by: hsa:3945
constant: false
is encoded by: hsa:3939
initial amount: NaN
initial concentration: NaN
has part: P00338
has only substance units: false
type: Species
name: LDHA:LDHB
is: SBO:0000297
has part: P07195

http://identifiers.org/biomodels.db/MODEL1310110044#_153ab037_533a_464e_97f5_852a5d7913af
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI684467
constant: false
is: SBO:0000252
type: Species
name: _AI684467_1_m
has only substance units: false
initial concentration: NaN

metaM ttdca c
boundary condition: false
name: myristate
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:30807
is: SBO:0000247
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: HMDB00806
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_e08397ed_ee8e_43a4_84ce_7bc2c4fc9f0e
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4717
name: NDUFC1
initial concentration: NaN
is: O43677
type: Species

metaR r1400
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110044#
name: Active transport
is described by: ECO:0000000
reactant: MODEL1310110044#
type: Reaction
reversible: false
fast: false
is: SBO:0000185

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM dhcrm hs c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
type: Species
is: CHEBI:31488
name: dihydroceramide
boundary condition: false
constant: false

metaM duri c
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: HMDB00012
is: C00526
type: Species
boundary condition: false
is: CHEBI:16450

http://identifiers.org/biomodels.db/MODEL1310110044#_e09ef6e9_0490_4f94_b584_94388a3cba25
is: SBO:0000252
is: P38571
has only substance units: false
initial amount: NaN
is encoded by: hsa:3988
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: LIPA

metaR GluForTx
fast: false
name: Glutamate formimidoyltransferase
product: MODEL1310110044#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.5
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110044#_094162fe_981c_4d87_b4a9_89bbf180f710
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR ACALDt
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
name: acetaldehyde reversible transport
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r0142
product: MODEL1310110044#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110044#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_bd8f9fc9_40ad_4970_a251_d203fba84f9f
type: Species
is: Q9BY49
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PECR
is encoded by: hsa:55825
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_b4492574_ad10_4a5e_acff_d841929e7a38
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4707
is: O75438
boundary condition: true
name: NDUFB1
has only substance units: false
is: SBO:0000252
type: Species

metaR r2112
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8bb272a5_b2f4_432c_a067_95e0e5da0ff4
constant: false
is encoded by: hsa:AA081045
name: _AA081045_1_e
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR r2195
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
reversible: true

metaM maltpt e
boundary condition: false
initial amount: NaN
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
has only substance units: false
constant: false
is: C02052
is: SBO:0000247
is: HMDB01296
type: Species

metaM nac c
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
is: C00253
is: HMDB01488
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:0
is: SBO:0000247
constant: false
type: Species
name: Nicotinate

http://identifiers.org/biomodels.db/MODEL1310110044#_e599298c_25f1_4014_b077_1c3537661527
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: _HG2846_HT2983_1_c
is encoded by: hsa:HG2846-HT2983

http://identifiers.org/biomodels.db/MODEL1310110044#_fccba6d7_a179_422d_b955_97afe82b223f
type: Species
has only substance units: false
is encoded by: hsa:29922
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NME7

http://identifiers.org/biomodels.db/MODEL1310110044#_ec61fe79_0170_4fce_af39_c711f759b27e
is encoded by: hsa:D87002
is: SBO:0000252
initial concentration: NaN
name: _D87002_1_m
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaR FAOXC165C164m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_749a53a1_2302_4e62_aa6d_06c4908515ca
name: SLC34A2
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:10568
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: O95436

metaR ARACHDCOAtx
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110044#

metaR DGTPtn
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
name: dGTP diffusion in nucleus
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110044#

metaR PGISr
reversible: true
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
fast: false
name: Prostaglandin I2 synthase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
is version of: http://identifiers.org/ec-code/5.3.99.4
is: SBO:0000176
kinetic law: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_ab6335d7_4ee2_41d8_a60a_3a47b261e090
is encoded by: hsa:6470
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: SHMT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_95d9a131_bc12_4217_a7e1_2ad0866b9f47
is encoded by: hsa:587
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: BCAT2
is: O15382
type: Species
has only substance units: false

metaM pail45p hs m
has only substance units: false
is: CHEBI:28910
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM c6crn x
is: HMDB00705
boundary condition: false
constant: false
initial concentration: 1.0
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r2194
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR DSAT
reversible: false
name: dihydrosphingosine N-acyltransferase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR UMPKm
name: UMP kinase (mitochondrial, ATP)
fast: false
is described by: ECO:0000134
product: MODEL1310110044#
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_b9568833_2bd1_4e73_95b1_e836d85def8b
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AI769281_1_e
is encoded by: hsa:AI769281

http://identifiers.org/biomodels.db/MODEL1310110044#_fc3b10c5_3c57_446d_a642_8c2c451d1190
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: MDH2
initial amount: NaN
constant: false
is encoded by: hsa:4191
is: P40926
boundary condition: true

metaR C4DCCACT
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_ef90dfc0_e42d_46f9_b6b6_158938d1791b
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI469183
constant: false
name: _AI469183_1_x

metaR NAt3 1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
fast: false
is described by: ECO:0000269
name: sodium proton antiporter (H:NA is 1:1)
product: MODEL1310110044#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110044#_68ef0007_6781_409d_99f9_bdcb81a58b5a
boundary condition: true
type: Species
initial amount: NaN
is: O43280
constant: false
is: SBO:0000252
is encoded by: hsa:11181
initial concentration: NaN
has only substance units: false
name: TREH

metaM gly m
constant: false
name: Glycine
boundary condition: false
has only substance units: false
is: HMDB00123
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: C00037
initial concentration: 1.0
is: CHEBI:15428
initial amount: NaN
type: Species

metaR r1639
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM xtsn c
boundary condition: false
is: CHEBI:18107
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00299
initial concentration: 1.0
has only substance units: false
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM itacon m
boundary condition: false
name: itaconate(2-)
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:17240
has only substance units: false
is: HMDB02092
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490

http://identifiers.org/biomodels.db/MODEL1310110044#_3fd3b9f0_2b0b_450a_be68_186df2c9643f
type: Species
constant: false
name: GAPDHS
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O14556
initial amount: NaN
is encoded by: hsa:26330

metaR r0686
kinetic law: MODEL1310110044#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
type: Reaction

metaR r2110
modifier: MODEL1310110044#
fast: false
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000000

metaM c226crn c
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0
is: HMDB06510
name: cervonyl carnitine
type: Species
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247

metaR MTRI
product: MODEL1310110044#
type: Reaction
name: 5-methylthioribose-1-phosphate isomerase
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:

metaM ethamp c
is: HMDB00224
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: ethamp[c]
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110044#_2716cc8f_c585_43dd_aae0_0dee917d991c
constant: false
initial amount: NaN
is: P27144
is: SBO:0000252
has only substance units: false
is encoded by: hsa:205
initial concentration: NaN
boundary condition: true
name: AK4
type: Species

metaR r1495
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:

metaR UMPKn
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
kinetic law: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
type: Reaction
fast: false
name: UMP kinase, nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR LNLNCGt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110044#

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR r0365
fast: false
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR PItn
fast: false
reversible: true
name: phosphate transport, nuclear
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8a28bff5_6661_4749_8d96_112e214cd1aa
is encoded by: hsa:3945
type: Species
is: P07195
has only substance units: false
name: LDHB
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR r2526
fast: false
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_ce5beca2_7b96_4d99_812c_94d1f7207459
is encoded by: hsa:AI222095
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI222095_1_m
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM occoa m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: CHEBI:57386
constant: false
has only substance units: false
type: Species
is: HMDB01070
is: C01944

metaR PEAMNO
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
fast: false
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: Phenethylamine oxidase
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185

metaM 2dodtricoa m
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05280
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 2,6,9-dodecatrienoylcoa
is: HMDB03952

metaR r1637
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r2525
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110044#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110044#
fast: false

metaR r0688
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#

metaR ALOX5
reversible: false
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Arachidonate 5-lipoxygenase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
fast: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is described by: ECO:0000269
reactant: MODEL1310110044#

metaM btcoa m
is: SBO:0000247
initial concentration: 1.0
is: C00136
boundary condition: false
constant: false
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
has only substance units: false
initial amount: NaN
name: Butanoyl-CoA
type: Species
is: CHEBI:57371

metaM dcsptn1coa m
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
is: HMDB06513
type: Species
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_db07ee9c_185b_40bc_be53_4a930616b487
constant: false
initial concentration: NaN
boundary condition: true
has part: O00459
has only substance units: false
type: Species
has part: P42336
name: PIK3CA:PIK3R2
is: SBO:0000297
is encoded by: hsa:5290
is encoded by: hsa:5296
initial amount: NaN

metaM docosahexcoa m
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
constant: false

metaR ATPtx
type: Reaction
name: ATP transporter, peroxisomal
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
product: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
name: prostaglandin F2alpha(1-)
has only substance units: false
constant: false
is: HMDB01139
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57404

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_2273f39e_c354_43c4_a1d3_1cfa2380f9fe
has only substance units: false
name: FLAD1
initial amount: NaN
boundary condition: true
is encoded by: hsa:80308
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_df79b810_95f0_47da_ba3d_2d4f518ecdb5
name: SLC9A1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6548
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: P19634

metaM 34dhmald m
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7903
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
type: Species
is: C05577
is: SBO:0000247
has only substance units: false
is: HMDB06242
boundary condition: false
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110044#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185

metaM prostgi2 r
name: prostaglandin I2(1-)
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01335
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_47a5d108_40d9_4f7c_9c6c_1325cef71f92
boundary condition: true
is: P14672
is: SBO:0000252
is encoded by: hsa:6517
has only substance units: false
type: Species
initial concentration: NaN
name: SLC2A4
constant: false
initial amount: NaN

metaR FUM
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.2
kinetic law: MODEL1310110044#
name: fumarase
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#

metaM o2s m
constant: false
is: CHEBI:18421
boundary condition: false
initial concentration: 1.0
name: Superoxide anion
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: SBO:0000247
is: HMDB02168
type: Species
initial amount: NaN

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR NADtpu
kinetic law: MODEL1310110044#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
name: NAD transporter, peroxisome
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#

metaM dgdp c
boundary condition: false
initial amount: NaN
is: C00361
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58595
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP
is: HMDB00960

metaR GCHOLAte
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
name: bile acid intracellular transport
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction

metaM 34dhmald c
is: http://identifiers.org/pubchem.compound/7903
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06242
is: C05577
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r1156
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: true
fast: false
type: Reaction
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is described by: ECO:0000000
kinetic law: MODEL1310110044#

metaM h e
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: CHEBI:24636
boundary condition: false
is: SBO:0000247
is: C00080
name: proton

metaR HDCAtr
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#
fast: false
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110044#

metaM CE5854 e
constant: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
initial amount: NaN
type: Species
name: gama-CEHC-glucuronide
is: SBO:0000247
has only substance units: false
is: HMDB02710
is: CHEBI:27485
boundary condition: false

metaM duri m
name: 2'-deoxyuridine
is: CHEBI:16450
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
is: HMDB00012
initial amount: NaN

metaR r2041
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110044#_194c32bd_2a14_463c_bbac_c519647d6b23
boundary condition: true
has only substance units: false
name: RDH13
is: SBO:0000252
is: B3KVA3
constant: false
is encoded by: hsa:112724
initial amount: NaN
initial concentration: NaN
type: Species

metaM prostgi2 e
boundary condition: false
type: Species
is: CHEBI:57403
is: SBO:0000247
name: prostaglandin I2(1-)
is: HMDB01335
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false

metaR BHBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110044#

metaR r0795
reversible: false
name: Spontaneous reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false
type: Reaction

metaR C3STDH1r
product: MODEL1310110044#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ

http://identifiers.org/biomodels.db/MODEL1310110044#_7ed56c86_3300_4a36_8458_11b8cbdfd494
initial amount: NaN
constant: false
is: Q9H6Y6
has only substance units: false
boundary condition: true
initial concentration: NaN
name: MYO5B
is encoded by: hsa:4645
is: SBO:0000252
type: Species

metaR LAPCOAe
product: MODEL1310110044#
is described by: ECO:0000134
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
fast: false
name: LAPCOAe
reversible: false

metaR FAOXC164m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR r1635
kinetic law: MODEL1310110044#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#

metaR r0716
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110044#
reversible: false
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
fast: false

metaM mal L e
type: Species
initial concentration: 1.0
is: CHEBI:15589
is: HMDB00156
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: (S)-malate(2-)
boundary condition: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110044#_b235322c_708f_4445_a175_68cb5fa71c97
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:U37519
name: _U37519_1_c
initial concentration: NaN
initial amount: NaN

metaR r0360
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110044#
reversible: false
reactant: MODEL1310110044#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_64ba7078_f462_41cb_ae1f_4c32629a9315
is encoded by: hsa:10380
boundary condition: true
initial amount: NaN
is: O95861
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: BPNT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_57589699_db4c_4c9a_bbde_af877740cccc
is: Q9H008
has only substance units: false
boundary condition: true
initial concentration: NaN
name: LHPP
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:64077

metaM adp c
type: Species
initial amount: NaN
is: C00008
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247
name: ADP
initial concentration: 1.0
is: HMDB01341
is: CHEBI:16761
has only substance units: false

metaR OMPDC
is version of: http://identifiers.org/ec-code/2.4.2.10
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269

metaR NP1
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110044#
is described by: ECO:0000304
fast: false
name: nucleotide phosphatase
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_3ba33299_659c_4236_a441_3b25ac525aea
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: TPI1
constant: false
is encoded by: hsa:7167
initial concentration: NaN
is: Q53HE2

metaR FAOXC103C102m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_17c69bcb_fdab_40a4_ae69_619654e68fa7
constant: false
is: SBO:0000252
is encoded by: hsa:5315
is: P14618
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PKM2
type: Species
initial amount: NaN

metaM paps c
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58339
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: HMDB01134

http://identifiers.org/biomodels.db/MODEL1310110044#_3a283fd9_2f04_4ea6_a1b0_1a0988c0f051
name: PLCB1
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23236
has only substance units: false
is: Q9NQ66

http://identifiers.org/biomodels.db/MODEL1310110044#_f03af21d_4131_45ac_b9e8_c40a9061b702
is: SBO:0000252
has only substance units: false
is: B3KT84
name: SDR16C5
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:195814
initial concentration: NaN
boundary condition: true

metaR r0149
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
is described by: ECO:0000000

metaR HIBDm
is version of: http://identifiers.org/ec-code/1.1.1.31
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
product: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110044#

metaR r1636
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#

metaM Sfglutth c
type: Species
boundary condition: false
constant: false
is: HMDB01550
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: CHEBI:57688
initial amount: NaN
name: S-formylglutathionate(1-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r0717
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
product: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_c56f6751_6449_41c9_9957_5f73d8f9bce9
name: FOLR1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2348
type: Species
initial concentration: NaN
is: SBO:0000252

metaR LEUKTRF4t
is: SBO:0000185
name: leukotriene F4 transport
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_ae2ac82f_8440_4a29_a6ce_341027345535
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P15531
initial amount: NaN
is encoded by: hsa:4830
name: NME1
type: Species

metaR FAOXC221C201x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_fa309724_42f1_459b_a7af_a67ee5b77de8
name: DTYMK
is: SBO:0000252
initial amount: NaN
is: P23919
has only substance units: false
is encoded by: hsa:1841
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM glyc R m
is: SBO:0000247
name: D-glycerate
boundary condition: false
is: HMDB00139
type: Species
constant: false
has only substance units: false
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
initial concentration: 1.0

metaM h g
initial amount: NaN
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:24636
has only substance units: false
boundary condition: false
name: proton
type: Species

metaM dctp c
is: C00458
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
type: Species
has only substance units: false
name: dCTP

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reactant: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: glycine N-choloyltransferase EC:2.3.1.65
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaR r0714
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is: SBO:0000176
reversible: false

metaM mal L c
type: Species
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15589
initial amount: NaN
is: HMDB00156
name: (S)-malate(2-)

metaR PROSTGI2tr
product: MODEL1310110044#
name: Prostaglandin I2 transport (ER)
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true

metaM c226crn m
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
name: cervonyl carnitine
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR r1633
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM arachd x
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0
is: HMDB01043
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:32395
constant: false
has only substance units: false
name: arachidonate

metaM HC02206 c
initial concentration: 1.0
type: Species
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57399
has only substance units: false

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_314bdd06_69de_4446_b50f_b1248c39d886
is encoded by: hsa:215
name: ABCD1
initial concentration: NaN
constant: false
is: P33897
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c3eca638_7264_4cde_90b8_923ce0464223
has only substance units: false
is: Q7Z4L0
constant: false
name: COX8C
is encoded by: hsa:341947
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0796
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
kinetic law: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is: SBO:0000176
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#

metaR RE1517M
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110044#
name: RE1517
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110044#_f5208824_2021_4280_b38a_bcab9e53e166
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4952
initial concentration: NaN
name: OCRL
constant: false

metaR r1512
is: SBO:0000185
name: Utilized transport
product: MODEL1310110044#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110044#

metaR r0715
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.2.5
type: Reaction
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
is: SBO:0000176

metaR ARACHDtr
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
fast: false

metaR r1634
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000

metaM dcsptn1coa x
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
boundary condition: false
has only substance units: false
is: C16173

metaR r2197
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
reversible: true

metaR ACACt2m
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110044#
name: Acetoacetate mitochondrial transport via H+ symport
fast: false
reversible: true
kinetic law: MODEL1310110044#

metaR RE1447N
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
reversible: true
fast: false
kinetic law: MODEL1310110044#

metaM bilglcur r
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
initial amount: NaN

metaR XOL27OHtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
reactant: MODEL1310110044#
reversible: true
fast: false
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
name: 27 hydroxy cholesterol transport

http://identifiers.org/biomodels.db/MODEL1310110044#_f0cf9e82_d167_4d24_989b_08b8eff0e8fb
is: SBO:0000252
is: P43353
has only substance units: false
constant: false
boundary condition: true
name: ALDH3B1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:221
type: Species

metaR r0963
reactant: MODEL1310110044#
fast: false
name: Facilitated diffusion
type: Reaction
reversible: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaR SERDGLYexR
modifier: MODEL1310110044#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
name: D-Serine/Glycine reversible exchange
fast: false
is: SBO:0000185
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
type: Reaction

metaR r1631
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110044#_110f2fda_597f_488e_8890_a6de06eaa0ef
constant: false
is encoded by: hsa:6578
is: SBO:0000252
boundary condition: true
name: SLCO2A1
is: Q92959
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.1
name: nicotinamide-nucleotide adenylyltransferase
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
is described by: ECO:0000269

metaM HC00591 c
is: CHEBI:16769
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: 2-oxoglutaramate
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species

metaM L2aadp6sa c
is: HMDB01263
constant: false
name: L-allysine
type: Species
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
has only substance units: false
is: CHEBI:17917
is: SBO:0000247
initial concentration: 1.0

metaR C3STDH1Pr
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
modifier: MODEL1310110044#
reversible: false
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
fast: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
kinetic law: MODEL1310110044#

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM gly e
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:3339
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
is: C00037
is: HMDB00123
boundary condition: false
initial concentration: 1.0

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
initial amount: NaN
has only substance units: false
name: octadecanoate (n-C18:0)
is: C01530
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB00827
is: CHEBI:25629

metaR r2196
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_1d908dc6_33ff_4998_b28e_5246df102d71
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: HSD3B1
is: P14060
constant: false
type: Species
is encoded by: hsa:3283
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_ef82214b_04ba_40d5_aa82_de5f5f2dae66
boundary condition: true
has only substance units: false
name: LYZL1
is encoded by: hsa:84569
is: Q6UWQ5
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r0145
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
modifier: MODEL1310110044#
type: Reaction
fast: false
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
reversible: true

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r1164
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
fast: false
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: EC:2.3.1.26
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110044#

metaR SPODMm
modifier: MODEL1310110044#
is described by: ECO:0000304
kinetic law: MODEL1310110044#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
name: superoxide dismutase
type: Reaction

metaM ala L c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00161
is: CHEBI:16977
type: Species
boundary condition: false
initial concentration: 1.0
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110044#_5faa8622_ea0c_45a2_951f_9a7d7ba9f34f
is encoded by: hsa:7378
is: SBO:0000252
boundary condition: true
name: UPP1
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR r1632
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185

metaM arachd r
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
initial concentration: 1.0
name: arachidonate
is: HMDB01043
is: SBO:0000247

metaR RE1447M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110044#
type: Reaction
fast: false
modifier: MODEL1310110044#
name: RE1447

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR r2119
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaR ILETA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
modifier: MODEL1310110044#
product: MODEL1310110044#
name: isoleucine transaminase
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
fast: false

metaM h c
name: proton
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
initial amount: NaN
is: CHEBI:24636
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: C00080
constant: false

metaM 4mop c
type: Species
initial concentration: 1.0
is: HMDB00695
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: 4-methyl-2-oxopentanoate

http://identifiers.org/biomodels.db/MODEL1310110044#_6974837e_51d8_4194_928b_547a7d756ac0
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q8IZH9
constant: false
is encoded by: hsa:2643
name: GCH1
type: Species
initial amount: NaN

metaM dhf m
boundary condition: false
has only substance units: false
is: CHEBI:57451
initial amount: NaN
name: dihydrofolate(2-)
is: SBO:0000247
is: HMDB01056
constant: false
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0

metaR TRDR
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110044#
is: SBO:0000176
fast: false
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
name: thioredoxin reductase (NADPH)

http://identifiers.org/biomodels.db/MODEL1310110044#_4fbddeee_4866_4376_8631_d830ce41629e
boundary condition: true
name: LDHAL6B
is: Q9BYZ2
is: SBO:0000252
is encoded by: hsa:92483
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_06978058_f896_4488_8c30_7889de1ea3ce
constant: false
initial amount: NaN
has only substance units: false
name: ACLY
is encoded by: hsa:47
boundary condition: true
initial concentration: NaN
is: P53396
is: SBO:0000252
type: Species

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_d8beb7ba_5d7e_4adb_8484_04fc4afd1393
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:108
is: Q71UM8
has only substance units: false
initial concentration: NaN
name: ADCY2

metaR r0033
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
product: MODEL1310110044#
modifier: MODEL1310110044#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reversible: false
kinetic law: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_c6db26f9_d519_45bc_bd1b_06114041edc8
is encoded by: hsa:4705
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: NDUFA10
constant: false
boundary condition: true
is: O95299

metaR r0718
type: Reaction
product: MODEL1310110044#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
is: SBO:0000176
reactant: MODEL1310110044#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_839e1f0f_392d_4c9a_9de9_39614692803d
initial amount: NaN
has only substance units: false
type: Species
name: PPAP2C
boundary condition: true
initial concentration: NaN
is: E9PAY8
is encoded by: hsa:8612
is: SBO:0000252
constant: false

metaR DHCR242r
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
product: MODEL1310110044#
is: SBO:0000176
name: 24-dehydrocholesterol reductase [Precursor]
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reversible: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#

metaM ocdca c
name: stearate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species
is: HMDB00827
is: CHEBI:25629
has only substance units: false

metaR ACNAMtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110044#
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110044#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110044#

metaR r2116
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM CE2838 e
initial amount: NaN
name: maltononaose
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM duri n
type: Species
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: HMDB00012
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 2'-deoxyuridine
constant: false
has only substance units: false

metaR r2198
modifier: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM lpam m
constant: false
name: lipoamide
initial concentration: 1.0
has only substance units: false
is: HMDB00962
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
is: CHEBI:17460

metaR r1630
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110044#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110044#

metaM HC01376 m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: S-(2-Methylbutanoyl)-dihydrolipoamide
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
has only substance units: false
initial amount: NaN
is: CHEBI:28692
constant: false

metaR r0960
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_040d9a5b_7ac5_4ed4_a746_15b615084683
type: Species
has only substance units: false
constant: false
is: O43426
name: SYNJ1
is encoded by: hsa:8867
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM xolest2 hs e
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
name: cholesterol ester
boundary condition: false
is: CHEBI:17002
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
is: HMDB00161
is: CHEBI:16977
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR PSFLIPm
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
reversible: false
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
name: phosphatidylserine flippase
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110044#

metaR r2117
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110044#

metaR PIter
is described by: ECO:0000212
is: SBO:0000185
reversible: true
name: phosphate transport, endoplasmic reticulum
product: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0646378a_be71_4a2a_84eb_7a900c4575b1
is: Q96M32
initial concentration: NaN
name: AK7
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:122481

http://identifiers.org/biomodels.db/MODEL1310110044#_aea85bb9_e586_446a_b287_762e3b548a04
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: O43570
name: CA12
constant: false
type: Species
is encoded by: hsa:771

metaM acald c
has only substance units: false
is: HMDB00990
name: acetaldehyde
initial concentration: 1.0
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaM HC01444 e
is: CHEBI:15754
name: Galactosylglycerol
has only substance units: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaM 5dhf e
constant: false
is: HMDB06487
type: Species
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110044#_c288d0a3_54ca_4300_b397_706449f89f8f
boundary condition: true
name: SLC5A11
has only substance units: false
is: Q8WWX8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:115584
constant: false
is: SBO:0000252
type: Species

metaR PMEVKx
modifier: MODEL1310110044#
is described by: ECO:0000134
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
product: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.2
is: SBO:0000176
fast: false
name: phosphomevalonate kinase
kinetic law: MODEL1310110044#
type: Reaction

metaM ps hs m
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
name: ps_hs[m]
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18303

metaR r2314
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#

metaM gdp m
is: C00035
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
is: HMDB01201
constant: false
name: GDP
is: CHEBI:58189
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM 2decdicoa m
name: 2,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false

metaM no e
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16480
is: HMDB03378
initial amount: NaN
is: C00533
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide

metaR UMPK2n
reactant: MODEL1310110044#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000269
name: UMP kinase (CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110044#

metaR r0474
kinetic law: MODEL1310110044#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110044#

metaM b2coa m
name: crotonoyl-CoA(4-)
is: SBO:0000247
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB02009
is: CHEBI:57332
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_2373e079_54b4_4d0b_8114_b9a614dde597
is encoded by: hsa:1215
is: Q4FEB3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: CMA1

metaR r1365
name: Vesicular transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: false
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_8a3f4534_1beb_49eb_9d26_0e4c062e7fa9
is: Q6P1K9
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: PANK2
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_fc600fba_2a8b_4089_be79_7a62830573dd
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _NOS2A_1_e
type: Species
is encoded by: hsa:NOS2A

metaM gdp n
is: HMDB01201
is: SBO:0000247
constant: false
type: Species
name: GDP(3-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaM HC02187 e
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species
has only substance units: false
boundary condition: false
name: reverse-triiodthyronine
is: CHEBI:28774
initial amount: NaN

metaR O2St
is described by: ECO:0000000
name: superoxide anion transport via diffusion (extracellular)
fast: false
is: SBO:0000185
reactant: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
product: MODEL1310110044#

metaR r2315
product: MODEL1310110044#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR FOLt2le
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000134
name: folate transport via anion exchange
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_6ec0526c_aac9_4b63_8635_d0267f7ef2b6
constant: false
is encoded by: hsa:4831
type: Species
boundary condition: true
name: NME2
initial amount: NaN
is: P22392
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_c55ae101_e504_47b5_b87a_6e45a3825b9e
boundary condition: true
is: SBO:0000252
name: _LOC374569_1_e
constant: false
type: Species
is encoded by: hsa:LOC374569
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_2c6f4c58_da46_4ab5_8e46_19fc50d430a6
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: O95528
is: SBO:0000252
has only substance units: false
is encoded by: hsa:81031
constant: false
name: SLC2A10

metaR SADT
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110044#
fast: false
reversible: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: sulfate adenylyltransferase

metaR C6CRNe
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaR r1364
name: Vesicular transport
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
reversible: false
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR G6PPer
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.3.9
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
modifier: MODEL1310110044#
name: glucose-6-phosphate phosphatase, edoplasmic reticular
fast: false
reactant: MODEL1310110044#
reversible: false
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_b64be092_e45a_4415_9d6f_b1d3d37df969
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: O75874
name: IDH1
constant: false
is encoded by: hsa:3417
initial amount: NaN

metaR GLUDxm
reversible: true
product: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110044#
fast: false
name: glutamate dehydrogenase (NAD) (mitochondrial)
type: Reaction
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110044#
is described by: ECO:0000269

metaM orn m
is: SBO:0000247
initial amount: NaN
is: CHEBI:46912
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
name: Ornithine
is: HMDB00214
type: Species
is: C01602
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_69b6c846_b100_4161_aec7_245e62485e8e
name: PRPS2
is encoded by: hsa:5634
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P11908
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaM Rtotal2 e
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00255
is: HMDB00244
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:3554
constant: false
name: R total 2 position

http://identifiers.org/biomodels.db/MODEL1310110044#_282dcb38_f816_459c_881a_15b4c9116f60
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:X63359
name: _X63359_1_c

http://identifiers.org/biomodels.db/MODEL1310110044#_6a743a63_97d9_420a_871a_31f6a2af73cb
type: Species
boundary condition: true
is: Q13011
is encoded by: hsa:1891
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: ECH1
has only substance units: false

metaM no c
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16480
is: HMDB03378
initial amount: NaN
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
is: SBO:0000247
name: Nitric oxide

metaM HC00900 c
is: SBO:0000247
initial amount: NaN
is: CHEBI:30860
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
initial concentration: 1.0
name: Methylmalonate
boundary condition: false
has only substance units: false

metaR r2316
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_f8e00341_0ed9_4455_957f_1cfcbb9f21b7
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: P48735
initial concentration: NaN
initial amount: NaN
name: IDH2
type: Species
is encoded by: hsa:3418

metaR r0472
type: Reaction
reactant: MODEL1310110044#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_336452ec_5ae1_421e_b12e_290dbe296367
has only substance units: false
is: Q16718
type: Species
boundary condition: true
constant: false
name: NDUFA5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4698
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_8c651c6c_8339_420e_bfc2_e0e45617a02c
is: C9JZ62
name: TMEM91
boundary condition: true
initial concentration: NaN
is encoded by: hsa:641649
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM gln L m
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00641
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine

metaR r1172
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
name: EC:3.1.1.13
type: Reaction
reversible: false

metaR 3HCO3 NAt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
name: 3HCO3_NAt
type: Reaction
fast: false
kinetic law: MODEL1310110044#

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_6b8b234d_06b2_45dd_baee_c9c1d9796fcf
boundary condition: true
constant: false
initial amount: NaN
is: D9HTE9
is encoded by: hsa:6576
has only substance units: false
type: Species
name: SLC25A1
is: SBO:0000252
initial concentration: NaN

metaM HC01118 r
has only substance units: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
type: Species
is: CHEBI:57310
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: presqualene diphosphate(3-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_976d7d11_7bce_42fd_9086_cb8d90392479
is: O94903
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:11212
has only substance units: false
name: PROSC
initial concentration: NaN
boundary condition: true
constant: false

metaM HC02187 c
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species
boundary condition: false
name: reverse-triiodthyronine
is: CHEBI:28774

metaR TXA2tr
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
name: thromboxane A2 intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
reactant: MODEL1310110044#
type: Reaction
fast: false

metaR BTNDe
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is: SBO:0000176
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110044#
product: MODEL1310110044#
name: biotinidase (biotin), extracellular
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110044#
reversible: false
fast: false

metaM fald c
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: SBO:0000247
name: formaldehyde
is: HMDB01426
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16842
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_f9f69422_8516_48b8_9e2d_9b82a8a4debe
is: SBO:0000252
boundary condition: true
type: Species
is: B7Z6Q4
name: IMPA1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3612
initial amount: NaN

metaR HISD
reversible: false
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: histidase
fast: false
is version of: http://identifiers.org/ec-code/4.3.1.3
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_3f34ebed_4274_43eb_b14b_120988908fc2
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: CA14
type: Species
initial amount: NaN
is encoded by: hsa:23632
is: A8K3J4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_e2e96db6_94e3_4072_8dc0_b291578df7dd
is: SBO:0000252
is encoded by: hsa:8277
name: TKTL1
initial amount: NaN
type: Species
is: B7Z7I0
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r2317
product: MODEL1310110044#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_7b7d21a7_afee_4636_aec3_443b5fbf2519
is: Q16795
type: Species
is encoded by: hsa:4704
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFA9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_20aded94_7ecc_40e0_bb1d_f0e8e581e096
initial concentration: NaN
is: P11168
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC2A2
has only substance units: false
constant: false
is encoded by: hsa:6514
type: Species

metaR r0720
kinetic law: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_99f00685_41ad_489c_a6dc_9498b1f255fa
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q8N142
constant: false
is encoded by: hsa:122622
is: SBO:0000252
name: ADSSL1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_8e977f28_01f3_4c4a_bf60_e9294ae4d820
has only substance units: false
is: C9JT23
boundary condition: true
name: NDUFA11
is encoded by: hsa:126328
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaM dcsptn1coa c
is: SBO:0000247
is: HMDB06513
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

metaR NMNATn
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: nicotinamide-nucleotide adenylyltransferase
fast: false
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
is version of: http://identifiers.org/ec-code/2.7.7.1

metaR SERGLNexR
reversible: true
reactant: MODEL1310110044#
name: L-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
fast: false
modifier: MODEL1310110044#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR ACACT1r
kinetic law: MODEL1310110044#
reversible: true
name: acetyl-CoA C-acetyltransferase
type: Reaction
reactant: MODEL1310110044#
fast: false
is: SBO:0000176
modifier: MODEL1310110044#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
product: MODEL1310110044#

metaM ach c
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15355
is: HMDB00895
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0a84ea95_dc51_48c0_9897_307eef2cc057
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: MGST3
initial amount: NaN
is: O14880
is encoded by: hsa:4259
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_f280f285_5bbc_473c_a5af_2c012c7ee719
initial concentration: NaN
name: _AI601100_1_m
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI601100
has only substance units: false
boundary condition: true

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02329
is: CHEBI:30623
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_da177ff6_062f_4941_9e39_b881969be2e9
is: SBO:0000252
is encoded by: hsa:6005
constant: false
name: RHAG
type: Species
initial concentration: NaN
initial amount: NaN
is: Q96E98
has only substance units: false
boundary condition: true

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR FAOXC184m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR ACOX22x
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.99.3
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
kinetic law: MODEL1310110044#
product: MODEL1310110044#
fast: false
is: SBO:0000176
is described by: ECO:0000304
reversible: false
name: acyl-Coenzyme A oxidase 2, branched chain

metaR DCSPTN1COAtx
name: fatty acid intracellular transport
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR ADNt
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: adenosine facilated transport in cytosol
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:7916
name: (R)-Pantothenate
has only substance units: false

metaR r2310
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110044#_176564e6_7f56_4d5e_8f11_0797802297fa
initial concentration: NaN
constant: false
has only substance units: false
is: Q9H2U2
name: PPA2
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:27068

metaR r0722
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.3.12
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaR NDPK5n
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
name: dADP(3-)
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01508
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR ACACT1x
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
fast: false
modifier: MODEL1310110044#
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110044#

metaR MANt4
is: SBO:0000185
reversible: true
is described by: ECO:0000269
fast: false
name: D-mannose transport via sodium cotransport
product: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

metaM CE5101 m
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
boundary condition: false
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110044#_f686defe_7ec2_4c5f_b75c_dc509fa25b0b
is encoded by: hsa:6518
initial amount: NaN
is: P22732
name: SLC2A5
initial concentration: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaM ach e
name: acetylcholine
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
initial concentration: 1.0
is: HMDB00895
is: CHEBI:15355
is: SBO:0000247

metaM phaccoa c
type: Species
constant: false
name: phenylacetyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
is: CHEBI:57390
boundary condition: false
is: SBO:0000247
is: HMDB06503
has only substance units: false
initial concentration: 1.0

metaR ASCBOX
reactant: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
name: ascorbic acid oxidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110044#

metaM 2mbcoa m
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: 2-methylbutanoyl-CoA(4-)
is: HMDB01041
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM dadp n
boundary condition: false
is: HMDB01508
initial amount: NaN
constant: false
initial concentration: 1.0
name: dADP(3-)
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667

http://identifiers.org/biomodels.db/MODEL1310110044#_409aa521_edb6_4475_9d4c_232d173fcc5a
is encoded by: hsa:2181
is: O95573
initial concentration: NaN
constant: false
is: SBO:0000252
name: ACSL3
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM ditp n
constant: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
is: CHEBI:61382
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB03537
boundary condition: false
initial amount: NaN
type: Species

metaM sphings c
type: Species
is: HMDB00252
name: sphingosine(1+)
boundary condition: false
initial amount: NaN
is: CHEBI:57756
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
constant: false
initial concentration: 1.0

metaR r2311
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_12a3b1c3_2006_43f8_90e8_31724a8811aa
is: SBO:0000252
name: NDUFS6
initial concentration: NaN
constant: false
is: Q6IBC4
is encoded by: hsa:4726
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR THRGLYexR
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110044#
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR CYTK13n
reversible: true
is: SBO:0000176
product: MODEL1310110044#
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000269

metaR RE2799C
type: Reaction
name: RE2799
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reactant: MODEL1310110044#

metaR ADSL2
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
type: Reaction
is: SBO:0000176
name: adenylosuccinate lyase
kinetic law: MODEL1310110044#
fast: false
reversible: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.3.2.2
is described by: ECO:0000269
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_59d814e8_8018_47f7_a2da_53c41fcfd31f
type: Species
is: O14521
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SDHD
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6392
constant: false

metaM srtn c
constant: false
has only substance units: false
name: serotonin(1+)
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:350546
is: HMDB00259
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

http://identifiers.org/biomodels.db/MODEL1310110044#_13f7d71b_6ed2_439d_9453_3f1dc91c07fe
is: SBO:0000252
name: CTPS2
is: Q9NRF8
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:56474

http://identifiers.org/biomodels.db/MODEL1310110044#_200785cb_72cd_4f11_904a_31883e2bb6ec
initial concentration: NaN
is: Q9NQR4
type: Species
is encoded by: hsa:56954
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: NIT2

metaR r2312
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
reversible: true
type: Reaction
product: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

metaM 6dhf e
has only substance units: false
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
constant: false
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB06563

metaR NTD7e
name: 5'-nucleotidase (AMP), extracellular
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000269
modifier: MODEL1310110044#
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#

metaM retn r
type: Species
initial concentration: 1.0
is: HMDB01852
boundary condition: false
name: all-trans-retinoate
constant: false
is: CHEBI:35291
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
has only substance units: false

metaR r2313
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110044#
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_aeeb629c_3986_4f3d_8e81_131c7dc02c9d
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:AI697028
initial concentration: NaN
name: _AI697028_1_e

metaR ADSL1
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
reversible: false
type: Reaction
is: SBO:0000176
name: adenylosuccinate lyase
is described by: ECO:0000269
product: MODEL1310110044#
reactant: MODEL1310110044#

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: true
type: Reaction
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_e85e0941_760a_44fc_867e_f596300e8e95
initial amount: NaN
name: ATP2B1
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: P20020
is encoded by: hsa:490
boundary condition: true

metaR CAATPS
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.6.3.8
kinetic law: MODEL1310110044#
product: MODEL1310110044#
name: Ca ATPase
fast: false
is: SBO:0000185
modifier: MODEL1310110044#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_28955f61_c41d_440b_97cf_9c49b7f9862c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:79717
name: PPCS
is: Q9HAB8
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR OROTGLUt
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000134
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: OROTGLUt
is: SBO:0000185

metaR RE0935E
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
name: RE0935
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110044#
is: SBO:0000176
modifier: MODEL1310110044#
fast: false
reversible: true

metaM 3mop e
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: HMDB00491
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28654
constant: false
initial concentration: 1.0

metaR r0475
is: SBO:0000176
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110044#

metaM ala L m
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00161
initial amount: NaN
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110044#_5ca32d8b_3e92_4076_98a5_bddac12535df
is: SBO:0000252
name: PIK3R1
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:5295
is: P27986
initial concentration: NaN

metaM 13 cis retn r
is: http://identifiers.org/pubchem.compound/7847414
initial concentration: 1.0
is: SBO:0000247
name: 13-cis-retinoate
constant: false
has only substance units: false
type: Species
is: HMDB06219
boundary condition: false
is: D00348
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial amount: NaN

metaR GALt1r
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: galactose transport (uniport)
type: Reaction
fast: false
product: MODEL1310110044#
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD

metaR PI4PLC
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
reversible: false

metaR UMPK3
is described by: ECO:0000269
fast: false
reactant: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: UMP kinase (UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110044#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110044#

metaR RE1807C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
name: RE1807
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_0270546e_1450_4799_8243_cf0405144e9d
is: SBO:0000252
is: Q5JPH6
is encoded by: hsa:124454
name: EARS2
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_ee258561_33f9_4a27_8fbe_b015d0db0023
is encoded by: hsa:7350
is: P25874
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: UCP1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR 10FTHFtm
is: SBO:0000185
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#

metaR r2520
product: MODEL1310110044#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_ebd0261d_bf56_4365_a309_44d39b8fb6f3
initial amount: NaN
name: AADAT
constant: false
is encoded by: hsa:51166
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q8N5Z0

metaM HC01501 c
is: CHEBI:33539
has only substance units: false
constant: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
initial amount: NaN
initial concentration: 1.0
type: Species
name: hydroxidodioxidosulfidosulfate(1-)
boundary condition: false
is: SBO:0000247

metaM uri c
type: Species
name: Uridine
is: CHEBI:16704
is: C00299
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM ps hs e
initial concentration: 1.0
boundary condition: false
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaM 2mpdhl m
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17577
boundary condition: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
type: Species
is: SBO:0000247
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false

metaR ALADGLYexR
is described by: ECO:0000304
reactant: MODEL1310110044#
reversible: true
fast: false
product: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
name: D-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_8842a1e3_5078_4065_94a9_56b397ae4f5a
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5959
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: RDH5
is: Q92781

metaR FALDH
fast: false
name: formaldehyde dehydrogenase
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaR r0614
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR NMNtn
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
name: NMN transport, nuclear trhough pore
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110044#

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
type: Reaction
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110044#
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reversible: true
is described by: ECO:0000000

metaR r0502
reactant: MODEL1310110044#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is version of: http://identifiers.org/ec-code/2.7.1.113
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is: SBO:0000176
modifier: MODEL1310110044#
is described by: ECO:0000000
fast: false
product: MODEL1310110044#
reversible: true
type: Reaction
kinetic law: MODEL1310110044#

metaR PIt8
reactant: MODEL1310110044#
name: phosphate transport in/out via Na+ symporter
product: MODEL1310110044#
is described by: ECO:0000006
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM

metaR UMPK2
reactant: MODEL1310110044#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110044#
name: UMP kinase (CTP)
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000269
fast: false
type: Reaction

metaM orn e
is: C01602
name: Ornithine
initial concentration: 1.0
constant: false
is: HMDB00214
is: CHEBI:0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
type: Species

metaM cit m
is: CHEBI:16947
initial concentration: 1.0
has only substance units: false
type: Species
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
constant: false
is: C00158
is: SBO:0000247
is: HMDB00094
initial amount: NaN

metaR FAOXC164C165m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR r2521
type: Reaction
name: Utilized transport
product: MODEL1310110044#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
fast: false
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true

metaR r0881
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
name: Active transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110044#
reactant: MODEL1310110044#

metaM fgam c
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
initial amount: NaN
is: C04376
has only substance units: false
constant: false
is: HMDB01308
is: CHEBI:58426
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM dc2coa m
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61406
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
name: trans-Dec-2-enoyl-CoA
boundary condition: false

metaR VALt4
kinetic law: MODEL1310110044#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000304
name: L-valine transport in via sodium symport
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000185

metaR PIt7
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: phosphate transport in/out via three Na+ symporter
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

metaM ala D c
name: D-alanine
type: Species
constant: false
has only substance units: false
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: CHEBI:15570
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_f715a8b2_6924_4f10_9166_e8192dce4d56
initial concentration: NaN
is encoded by: hsa:6240
type: Species
is: SBO:0000252
boundary condition: true
name: RRM1
initial amount: NaN
is: P23921
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_aed8a0ca_72ed_469d_b335_14a7ba6590eb
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA021081
name: _AA021081_1_r
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM gdp c
has only substance units: false
type: Species
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: C00035
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB01201
is: CHEBI:58189
boundary condition: false
name: GDP

metaM akg x
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: 2-oxoglutarate(2-)
is: CHEBI:16810
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_fb21fb8a_d223_4298_9b5b_5e873b6416e3
type: Species
is encoded by: hsa:1351
is: SBO:0000252
is: Q53XN1
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: COX8A

metaR r0801
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_f180fd07_df2b_4e95_828d_7f25b8b3ac38
name: VNN3:VNN2:VNN1
has part: A8K7W0
type: Species
is encoded by: hsa:55350
is encoded by: hsa:8876
has only substance units: false
is encoded by: hsa:8875
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
has part: O95497

http://identifiers.org/biomodels.db/MODEL1310110044#_68dcfbd3_246f_424a_b30c_d8e175c521c9
constant: false
is: P47989
type: Species
is encoded by: hsa:7498
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: XDH
has only substance units: false
initial amount: NaN

metaR r0616
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110044#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#

metaM ditp c
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
initial amount: NaN
has only substance units: false
is: CHEBI:61382
initial concentration: 1.0
is: SBO:0000247
is: HMDB03537

metaM ps hs c
boundary condition: false
name: ps_hs[c]
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_2a25adb2_3772_43df_bf19_428f384deb32
type: Species
name: ACSL4
constant: false
is: O60488
is encoded by: hsa:2182
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM uri e
is: HMDB00296
constant: false
is: C00299
boundary condition: false
is: CHEBI:16704
has only substance units: false
type: Species
initial amount: NaN
name: Uridine
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247

metaR BILDGLCURt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110044#
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
modifier: MODEL1310110044#
reversible: true

metaR DURAD2
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
name: dihydrothymin dehydrogenase (NADP)
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction

metaR r0584
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_b695c86e_aafa_4fcb_ad4d_663abfea3271
has only substance units: false
is: P14550
initial amount: NaN
constant: false
is encoded by: hsa:10327
is: SBO:0000252
initial concentration: NaN
type: Species
name: AKR1A1
boundary condition: true

metaR SMS
is version of: http://identifiers.org/ec-code/2.7.8.27
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#
modifier: MODEL1310110044#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
is described by: ECO:0000269

metaM c4dc x
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
name: succinyl carnitine
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB04047
initial amount: NaN
has only substance units: false
is: C14143

metaM dhdascb c
is: SBO:0000247
initial amount: NaN
is: HMDB01264
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: CHEBI:58070
name: dehydroascorbide(1-)
boundary condition: false

metaM cysam c
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
name: cysteaminium
has only substance units: false
is: CHEBI:58029
initial concentration: 1.0
boundary condition: false
is: HMDB02991

http://identifiers.org/biomodels.db/MODEL1310110044#_7c10e234_8488_44e0_8934_76703cab9926
type: Species
constant: false
initial amount: NaN
name: ALPP
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P05187
is encoded by: hsa:250
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_0d3deeab_2c18_4972_9edb_0a7ce5ffd39e
is: P55084
is: SBO:0000252
name: HADHB
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:3032
constant: false
initial amount: NaN

metaM ala D e
constant: false
is: HMDB01310
type: Species
name: D-alanine
has only substance units: false
is: CHEBI:15570
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR PROSTGF2t
modifier: MODEL1310110044#
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
reactant: MODEL1310110044#
is: SBO:0000185
reversible: true
product: MODEL1310110044#

metaR DINt
product: MODEL1310110044#
fast: false
kinetic law: MODEL1310110044#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110044#
type: Reaction
name: deoxyinosine transport via diffusion

metaR 4HGLSDm
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
modifier: MODEL1310110044#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000212
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_6571c968_85c4_4850_863d_855edaf96c2e
initial concentration: NaN
is: Q99424
is encoded by: hsa:8309
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: ACOX2
boundary condition: true

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaM HC02217 c
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
is: CHEBI:27647
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110044#_5fc4e568_26eb_41d4_b21e_843bfc7b5c7a
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
name: PLCB1
initial amount: NaN
boundary condition: true
is encoded by: hsa:23236
has only substance units: false

metaM ach n
constant: false
name: acetylcholine
initial concentration: 1.0
is: CHEBI:15355
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00895
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR UMPK7
product: MODEL1310110044#
is described by: ECO:0000269
reversible: true
name: UMP kinase (dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110044#
fast: false
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176

metaR LEUTA
is described by: ECO:0000269
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
name: leucine transaminase
modifier: MODEL1310110044#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
product: MODEL1310110044#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_cd476868_0cbe_469b_a10b_c53aa69e95f3
is: P19801
is encoded by: hsa:26
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: ABP1

metaR CYTK1n
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110044#
is: SBO:0000176
fast: false
modifier: MODEL1310110044#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_09f13b4a_c539_42f4_904b_797b85acaad4
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9BZX2
is encoded by: hsa:7371
has only substance units: false
name: UCK2

metaR RE1573M
product: MODEL1310110044#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110044#
name: RE1573
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/5.3.3.8
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR 34DHXMANDACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110044#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
product: MODEL1310110044#
is: SBO:0000176
reversible: true

metaR DNDPt26m
modifier: MODEL1310110044#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
name: dCDP transport via dUDP antiport
is: SBO:0000185
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110044#_1b320c0c_28e1_4ef3_80ee_70894d80c311
type: Species
is: SBO:0000252
is encoded by: hsa:26289
initial concentration: NaN
name: AK5
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0885
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
fast: false
reactant: MODEL1310110044#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
type: Reaction

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
reversible: true
name: D-proline transport, extracellular
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
is: SBO:0000185
reactant: MODEL1310110044#
is described by: ECO:0000134

metaM man c
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: D-Mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
initial concentration: 1.0
is: HMDB00169
is: SBO:0000247
is: CHEBI:16024

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
is: HMDB01070
constant: false
is: CHEBI:57386
type: Species
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C01944

metaR UMPK6
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110044#
reversible: true
name: UMP kinase (dCTP)
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_5ec689da_6521_4adb_aadf_dba7953ea1aa
initial amount: NaN
is: Q9UHW9
name: SLC12A6
is: SBO:0000252
is encoded by: hsa:9990
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_48286a0e_ae6a_4245_96cb_a29f3d1d96c7
name: _AD000092_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AD000092
initial amount: NaN
initial concentration: NaN
constant: false

metaR C14STRr
product: MODEL1310110044#
is described by: ECO:0000134
fast: false
type: Reaction
name: C-14 sterol reductase
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: false
is: SBO:0000176
reactant: MODEL1310110044#
modifier: MODEL1310110044#

metaR DUMPtn
is: SBO:0000185
product: MODEL1310110044#
name: dUMP nuclear transport
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_05d7a106_9532_422d_a21b_4379f56d4902
has only substance units: false
type: Species
initial amount: NaN
is: P36969
is encoded by: hsa:2879
boundary condition: true
constant: false
name: GPX4
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_c19d7338_468a_4f44_a375_ceef66ef787b
name: SLC2A13
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:114134
is: Q96QE2
initial amount: NaN

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
has only substance units: false
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA
boundary condition: false
is: CHEBI:28276
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM dgdp m
has only substance units: false
name: dGDP(2-)
is: CHEBI:58595
is: SBO:0000247
is: HMDB00960
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_4545cbbb_c9e9_4173_8659_bab13ff9c952
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: _AV727634_1_c
is encoded by: hsa:AV727634
is: SBO:0000252

metaM HC01842 c
is: CHEBI:31997
name: Phosphodimethylethanolamine
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
constant: false
initial amount: NaN
initial concentration: 1.0

metaR TXA2te
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
name: thromboxane A2 transport
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#

metaR r1960
reversible: false
is described by: ECO:0000000
product: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110044#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_b4adcf2b_d376_4e9a_bf0d_a969492f1421
has only substance units: false
initial amount: NaN
is encoded by: hsa:2653
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: GCSH
initial concentration: NaN
is: P23434

http://identifiers.org/biomodels.db/MODEL1310110044#_04739a07_516b_4da4_8016_17f8e3dc3819
type: Species
is: Q9BY07
name: SLC4A5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:57835

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR UMPK5
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110044#
is described by: ECO:0000269
modifier: MODEL1310110044#
name: UMP kinase (dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110044#
is: SBO:0000176
product: MODEL1310110044#

metaR r0504
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110044#
product: MODEL1310110044#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_c6868205_0823_4a51_92f9_25f3f7a59ca8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: RRM2B
is encoded by: hsa:50484
has only substance units: false
constant: false
is: Q7LG56
type: Species

metaM 1pipdn2c x
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
constant: false
name: 1-piperideine-2-carboxylate
type: Species
is: CHEBI:16187
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01084

metaM icit c
is: SBO:0000247
is: CHEBI:16087
has only substance units: false
name: Isocitrate
initial concentration: 1.0
is: HMDB00193
constant: false
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
type: Species
is: C00311

metaR RE2973C
name: RE2973
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
modifier: MODEL1310110044#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
product: MODEL1310110044#
type: Reaction

metaR DATPtn
name: dATP diffusion in nucleus
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM 3docopencoa m
name: 3,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_9313d633_642e_48cb_9491_e771b817ef92
is encoded by: hsa:28231
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: SLCO4A1
initial concentration: NaN
has only substance units: false
is: Q96BD0

http://identifiers.org/biomodels.db/MODEL1310110044#_50c52a9c_78bc_43de_847c_91bf09f39699
initial amount: NaN
is: Q9BZQ4
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: NMNAT2
is encoded by: hsa:23057
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_284e0407_b316_4290_9a32_9d3440cc3bd7
initial amount: NaN
constant: false
is encoded by: hsa:58510
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q9UF12
name: PRODH2
initial concentration: NaN
type: Species

metaM dgdp n
initial amount: NaN
is: HMDB00960
is: SBO:0000247
name: dGDP(2-)
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58595
constant: false

metaR CYStec
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
product: MODEL1310110044#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
name: L-cysteine transport via diffusion (extracellular to cytosol)

metaM acald e
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
is: CHEBI:15343
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00990

metaM man e
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: C00159
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
is: SBO:0000247
name: D-Mannose
constant: false
is: CHEBI:16024

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM nicrns c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB06809
is: CHEBI:58527
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
initial concentration: 1.0
boundary condition: false
name: Nicotinate D-ribonucleoside
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_92fc44a4_cfa8_4a62_a1f8_4e57ae1af1ac
initial amount: NaN
is encoded by: hsa:23533
is: Q8WYR1
boundary condition: true
has only substance units: false
name: PIK3R5
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaR UMPK4
kinetic law: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
reactant: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR r0580
kinetic law: MODEL1310110044#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
product: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction

metaR CYTK2n
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
name: cytidylate kinase (dCMP),nuclear
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269

metaR FAOXC161C141x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM 3mop m
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491
initial amount: NaN
is: CHEBI:28654
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110044#_cb231994_99b7_4038_a893_cba10fcf91f1
is encoded by: hsa:1593
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q02318
is: SBO:0000252
name: CYP27A1
initial concentration: NaN

metaM pchol hs r
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
name: Phosphatidylcholine
is: SBO:0000247
is: CHEBI:16110
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

metaM prostge2 c
is: CHEBI:606564
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
initial concentration: 1.0
is: HMDB01220
name: prostaglandin E2(1-)

metaM pail345p hs c
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57836
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)

http://identifiers.org/biomodels.db/MODEL1310110044#_15f6245f_35b2_4de6_b997_860e23ab913d
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC2A9
is encoded by: hsa:56606
type: Species
initial concentration: NaN

metaM 2mb2coa m
is: HMDB02054
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial amount: NaN
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
constant: false
boundary condition: false
is: CHEBI:57337

metaM 4ppan c
is: SBO:0000247
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: C03492
boundary condition: false
constant: false
is: CHEBI:10986
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: D-4'-Phosphopantothenate
type: Species

metaR RE1448N
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
name: RE1448
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#

metaM 5adtststerone e
is: CHEBI:16330
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0

metaM cit e
constant: false
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
is: HMDB00094
has only substance units: false
type: Species
is: CHEBI:16947
is: SBO:0000247
initial amount: NaN
name: citrate(3-)

metaM prostge2 e
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01220
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
is: CHEBI:606564
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_89de9199_4181_498e_b035_92384052ded3
initial amount: NaN
is: SBO:0000252
is: E7EQF2
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54677
boundary condition: true
type: Species
name: CROT

http://identifiers.org/biomodels.db/MODEL1310110044#_95487053_24a6_455d_b9f2_a1aa970796a4
name: PLCL1
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q15111
boundary condition: true
constant: false
is encoded by: hsa:5334

metaR r1629
type: Reaction
product: MODEL1310110044#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR r2100
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
type: Reaction
modifier: MODEL1310110044#
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_19cce4b6_b81c_4b42_9731_fe0a17cb7ea3
name: _AA576959_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AA576959
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_9b2d1c50_4b97_48de_8152_abb1ce3fc233
type: Species
constant: false
is encoded by: hsa:10423
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: CDIPT
initial concentration: NaN
is: A8K3L7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ec7dec72_5025_4977_9707_a6eb9abc2ad0
name: IDH1
is: O75874
is: SBO:0000252
is encoded by: hsa:3417
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_c8b6656a_1258_47b5_a768_dd0597aa5335
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4507
type: Species
is: Q13126
name: MTAP

http://identifiers.org/biomodels.db/MODEL1310110044#_c6f00946_f316_4f3a_80da_be7ee9598d7f
is encoded by: hsa:AA788780
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: _AA788780_1_c
is: SBO:0000252

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM methf c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: 5,10-Methenyltetrahydrofolate
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57455
constant: false
is: C00445
initial concentration: 1.0
is: HMDB01354

metaM 44mzym r
is: SBO:0000247
name: 14-demethyllanosterol
initial amount: NaN
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:18364
is: HMDB01286
has only substance units: false
boundary condition: false

metaR THP2Ctp
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110044#
type: Reaction
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
reactant: MODEL1310110044#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_107de47b_6177_4a3b_9d96_690c57ec61bb
is: Q9BYZ2
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:92483
initial concentration: NaN
boundary condition: true
name: LDHAL6B

metaM dhcholestanate c
has only substance units: false
initial concentration: 1.0
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
is: HMDB00359
is: SBO:0000247
initial amount: NaN
is: CHEBI:16577

metaM andrstandn r
is: CHEBI:15994
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00899
has only substance units: false
boundary condition: false
name: 5alpha-androstane-3,17-dione
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_013b11bb_72fc_412e_b388_87278652f65d
is: SBO:0000252
is encoded by: hsa:56301
is: Q9NS82
boundary condition: true
constant: false
name: SLC7A10
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_8195776f_1ae0_4a37_b5ba_0a6206ef818f
is encoded by: hsa:220
initial amount: NaN
name: ALDH1A3
boundary condition: true
has only substance units: false
constant: false
is: P47895
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_81d2682e_bb4b_4438_b999_90b431db61c5
is: SBO:0000252
type: Species
name: SDHB
has only substance units: false
is: P21912
initial amount: NaN
constant: false
is encoded by: hsa:6390
initial concentration: NaN
boundary condition: true

metaR r2101
reversible: true
reactant: MODEL1310110044#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
is described by: ECO:0000000

metaR FAOXC226C227m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR CLPNDCOAtx
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110044#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_e95b45ec_31a4_4e7d_97d9_8b468bcc188a
is: SBO:0000252
is: O95168
is encoded by: hsa:4710
initial concentration: NaN
name: NDUFB4
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_351aa238_0b21_4a22_8046_e4c7bfa86969
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q9ULD0
name: OGDHL
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55753

metaR ASNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
product: MODEL1310110044#
fast: false
name: Asparagine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110044#_f0f863a2_8892_4ee9_9852_2c0230386009
type: Species
name: SLC7A2
boundary condition: true
is: SBO:0000252
is: P52569
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6542
initial amount: NaN

metaM cit c
is: C00158
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
has only substance units: false
boundary condition: false
is: HMDB00094
type: Species
is: CHEBI:16947
is: SBO:0000247
name: Citrate

metaM 5adtststerone c
has only substance units: false
is: CHEBI:16330
boundary condition: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
type: Species
initial amount: NaN
is: HMDB02961
initial concentration: 1.0

metaM nadph c
initial concentration: 1.0
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57783
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_7b878d98_954e_4df2_bd70_eb91a8a387cf
is: SBO:0000252
initial concentration: NaN
type: Species
name: _U52111_1_c
has only substance units: false
is encoded by: hsa:U52111
initial amount: NaN
constant: false
boundary condition: true

metaR r2519
kinetic law: MODEL1310110044#
type: Reaction
is described by: ECO:0000000
name: Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
product: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185
fast: false

metaM prpncoa m
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: acryloyl-CoA(4-)
constant: false
type: Species
is: HMDB02307
is: CHEBI:57367
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894

metaM leuktrF4 e
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: CHEBI:27491
is: HMDB06465
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: leukotriene F4
initial concentration: 1.0

metaR r2102
modifier: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110044#
fast: false
type: Reaction
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000185

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR MANt1r
name: mannose transport (uniport)
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110044#
reactant: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185
kinetic law: MODEL1310110044#
reversible: true
type: Reaction
fast: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM xu5p D c
is: HMDB00868
is: SBO:0000247
constant: false
has only substance units: false
name: D-xylulose 5-phosphate(2-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
initial concentration: 1.0
type: Species
is: CHEBI:57737

metaM CE2705 c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: C00010
is: CHEBI:57287
constant: false
is: HMDB01423
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110044#_0f7230aa_82c7_4ee7_a221_b4f96d9266c3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AL048840
name: _AL048840_1_c
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110044#_704ca6c1_606c_470b_a3e2_8c2d52e595a3
name: LGSN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51557
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q5TDP6
is: SBO:0000252

metaR r2103
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
fast: false

metaR GTHPm
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.11.1.12
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.15
name: glutathione peroxidase, mitochondria
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)

metaM HC02217 e
is: SBO:0000247
type: Species
is: CHEBI:27647
constant: false
name: prostaglandin-g2
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_de0c1673_7d13_469c_a3d4_1d01fc5cc878
name: STS
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:412
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P08842

http://identifiers.org/biomodels.db/MODEL1310110044#_7523ba15_729e_4474_b7f8_b5a9ed7a4119
has part: O14521
is encoded by: hsa:6389
is encoded by: hsa:6392
has part: Q99643
has part: P31040
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6391
has part: P21912
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6390
initial amount: NaN
is: SBO:0000297
boundary condition: true
initial concentration: NaN

metaM biocyt e
type: Species
constant: false
is: SBO:0000247
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
has only substance units: false
is: HMDB03134
boundary condition: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_0b1c8dff_94e5_48af_9ef8_11184b66fa97
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:217
name: ALDH2
constant: false
is: P05091

metaM 5pmev x
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
name: (R)-5-phosphonatomevalonate(3-)
is: HMDB01343
is: CHEBI:58146
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaR r0578
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110044#
is: SBO:0000176
kinetic law: MODEL1310110044#
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
modifier: MODEL1310110044#
type: Reaction

metaR CRNt
reactant: MODEL1310110044#
name: L-carnitine reversible transport
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_161d151c_1509_4ef6_a78a_fd8e5e95339e
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ACAA1
is: Q96CA6
is encoded by: hsa:30
initial amount: NaN
constant: false

metaR r1625
reactant: MODEL1310110044#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR C3STKR2r
name: C-3 sterol keto reductase (zymosterol)
type: Reaction
is described by: ECO:0000134
reversible: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM leuktrF4 c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
name: leukotriene F4
initial amount: NaN
is: CHEBI:27491
boundary condition: false
is: HMDB06465
has only substance units: false

metaR ORNALArBATtc
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_24db84d9_51da_460d_8be6_89810017a1f0
name: CPT1B
type: Species
is encoded by: hsa:1375
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q92523
boundary condition: true

metaR LTD4DP
name: Leukotriene D4 dipeptidase
reversible: true
is: SBO:0000176
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
type: Reaction
fast: false

metaM HC01410 m
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:28706
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
type: Species
is: SBO:0000247

metaR OCTAt
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
name: Octanoate transport via diffusion
is: SBO:0000185
product: MODEL1310110044#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_f27b266d_8d26_448a_a42c_0b658808f3e0
initial concentration: NaN
type: Species
is encoded by: hsa:622
name: BDH1
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM leu L c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:15603
name: L-leucine
has only substance units: false
is: HMDB00687
constant: false
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

metaR r0579
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.19
fast: false
reactant: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
type: Reaction
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_4fa24466_be77_4d7c_ba29_345463562401
has only substance units: false
name: INPP5J
constant: false
initial amount: NaN
type: Species
is: Q15735
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27124

metaR RE2660N
name: RE2660
kinetic law: MODEL1310110044#
reversible: true
fast: false
product: MODEL1310110044#
modifier: MODEL1310110044#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:

metaR r1626
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110044#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
reactant: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000

metaR r0618
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#

metaM dd3coa x
has only substance units: false
type: Species
is: HMDB04257
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false
name: 3-dodecenoylcoa
is: SBO:0000247
initial concentration: 1.0

metaR MEVK1x
reactant: MODEL1310110044#
modifier: MODEL1310110044#
fast: false
name: mevalonate kinase (atp)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.36
kinetic law: MODEL1310110044#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
product: MODEL1310110044#
is: SBO:0000176

metaM gln L c
name: L-glutamine
is: CHEBI:18050
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

http://identifiers.org/biomodels.db/MODEL1310110044#_01cb31d0_d1d3_4199_8b41_ded325506a88
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:124935
is: Q8N370
has only substance units: false
name: SLC43A2
is: SBO:0000252

metaR DPCOAPPe
kinetic law: MODEL1310110044#
fast: false
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
name: Pyrophasphatase (dephospho-CoA, extracellular)
is: SBO:0000176
product: MODEL1310110044#
reversible: false
is described by: ECO:0000134

metaM c12dccoa x
initial concentration: 1.0
type: Species
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: HMDB04047
constant: false
boundary condition: false
is: C14143
has only substance units: false
is: SBO:0000247
name: dodecanedioylcoa
initial amount: NaN

metaM HC01223 m
constant: false
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047

metaM dece4coa m
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB02145
initial concentration: 1.0
has only substance units: false
type: Species
name: 4-decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false

metaR MMEm
fast: false
is: SBO:0000176
name: methylmalonyl-CoA epimerase/racemase
is version of: http://identifiers.org/ec-code/5.1.99.1
kinetic law: MODEL1310110044#
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000269
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

metaM crm hs c
initial concentration: 1.0
name: N-acylsphingosine
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
is: CHEBI:52639
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_74e192c3_f536_479a_b133_71790ed9e948
has part: Q96RQ3
is encoded by: hsa:64087
constant: false
has part: Q9HCC0
boundary condition: true
name: MCCC1:MCCC2
is encoded by: hsa:56922
is: SBO:0000297
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR r0698
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reactant: MODEL1310110044#
type: Reaction
modifier: MODEL1310110044#
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.1.2.27
fast: false
kinetic law: MODEL1310110044#
reversible: true
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110044#_5dabfe4d_2415_40f3_8190_f394337c0d6d
name: DGKA
is: P23743
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:1606
initial concentration: NaN

metaR r0377
is described by: ECO:0000000
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false

metaR r1418
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false

metaR r1148
reactant: MODEL1310110044#
reversible: true
name: Active transport
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
type: Reaction
product: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_fefe2cfe_9773_4ca2_9682_f99944a65518
name: _AI971036_1_c
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI971036
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_76ecb712_8cc5_415d_b9f9_292b85e8db0d
initial concentration: NaN
is: B1AM93
is: SBO:0000252
name: NDUFA8
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4702

http://identifiers.org/biomodels.db/MODEL1310110044#_71eff1d8_6f82_426a_9463_2b9512e34a43
is encoded by: hsa:978
constant: false
is: P32320
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: CDA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_c486ee7d_532a_43b8_a13f_59a0bedc3370
is: SBO:0000252
constant: false
name: SLC28A1
boundary condition: true
type: Species
initial concentration: NaN
is: O00337
has only substance units: false
is encoded by: hsa:9154
initial amount: NaN

metaR r1627
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_4c8ad6a6_000c_4c20_876b_8ae8352d0cf4
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:218
name: ALDH3A1
initial concentration: NaN
initial amount: NaN
is: P30838
constant: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_0b69a594_c6b1_4628_93c7_54d655ebc304
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q96I99
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8801
initial amount: NaN
name: SUCLG2

metaR EX 34hpp
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_a90d0caa_c0f3_46d0_a118_caa4338d2bff
constant: false
name: MTMR3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: Q13615
is encoded by: hsa:8897

metaM gsn c
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
is: SBO:0000247
is: C00387
boundary condition: false
is: HMDB00133
is: CHEBI:16750
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: Guanosine

http://identifiers.org/biomodels.db/MODEL1310110044#_c29d442c_00a6_4265_b407_24154306e4ef
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:23007
is: Q4KWH8
boundary condition: true
type: Species
name: PLCH1
is: SBO:0000252
has only substance units: false

metaR CHOLtn
name: Choline transport, nuclear through pores
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
product: MODEL1310110044#
is: SBO:0000185
fast: false
reactant: MODEL1310110044#
type: Reaction
reversible: true

metaM orn c
initial amount: NaN
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
has only substance units: false
is: CHEBI:0
is: HMDB00214
type: Species
constant: false
boundary condition: false
is: C01602
initial concentration: 1.0

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM acald m
has only substance units: false
boundary condition: false
is: HMDB00990
name: acetaldehyde
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
type: Species
initial amount: NaN

metaR RE3218C
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
fast: false
is described by: ECO:0000000
modifier: MODEL1310110044#
name: RE3218
product: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction

metaR FAOXC81C61m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM h x
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
constant: false
name: proton
is: CHEBI:24636
initial amount: NaN
has only substance units: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_48d4dd3f_91d9_4334_a1a1_7b7018ba1e2a
is encoded by: hsa:115111
boundary condition: true
has only substance units: false
name: SLC26A7
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM gam c
type: Species
name: D-Glucosamine
is: CHEBI:17315
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00329
boundary condition: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: HMDB01514

http://identifiers.org/biomodels.db/MODEL1310110044#_607fd899_f192_4f4d_8ee6_d8c54bd28066
is: SBO:0000252
is encoded by: hsa:3636
name: INPPL1
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: O15357

metaR FACOAL204
kinetic law: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is described by: ECO:0000269
modifier: MODEL1310110044#
name: fatty-acid--CoA ligase
product: MODEL1310110044#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110044#_b565be81_55df_43e8_978c_569cacdbdda8
initial amount: NaN
type: Species
name: BAAT
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q14032
is encoded by: hsa:570
constant: false
is: SBO:0000252

metaM gua c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00132
has only substance units: false
is: CHEBI:16235
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242
constant: false
name: Guanine

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR AACOAT
is described by: ECO:0000269
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
product: MODEL1310110044#
name: Acetoacetyl-CoA:acetate CoA-transferase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
type: Reaction
reversible: true

metaM 3mop c
is: SBO:0000247
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00491
type: Species

metaR UGT1A5r2
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (54576.1) or (54575.1) SUBSYSTEM: Vitamin A metabolism EC Number: 2.4.1.17 Confidence Level: 2 AUTHORS: PMID:14704335,PMID:1503811 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.17
fast: false
type: Reaction
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal (13-cis)

http://identifiers.org/biomodels.db/MODEL1310110044#_42da1b4e_a843_4303_ae47_5420a53d5af1
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:LOC728997
name: _LOC728997_1_c
initial concentration: NaN
boundary condition: true

metaM for r
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
constant: false
initial amount: NaN
type: Species
name: Formate
is: HMDB00142
is: SBO:0000247
is: CHEBI:15740

metaR RE3245C
is: SBO:0000176
product: MODEL1310110044#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
kinetic law: MODEL1310110044#
is described by: ECO:0000000
name: RE3245

metaR PPD2CSPp
name: PPD2CSPp
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is: SBO:0000176

metaR r0726
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#

metaR r1621
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110044#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110044#_ac20b0c6_ae48_4e35_afbc_519dfe07ae09
is encoded by: hsa:9194
name: SLC16A7
is: Q8NEM3
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR NADS2
type: Reaction
product: MODEL1310110044#
name: NAD synthase (glutamine-hydrolysing)
fast: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/6.3.5.1
reversible: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110044#
is: SBO:0000176
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_bc9ce3e8_9adf_4192_9ee7_9c606bf31cfb
name: DGKZ
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8525
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: B7Z6M3

http://identifiers.org/biomodels.db/MODEL1310110044#_d6d4b704_dd2b_4268_b54e_b7bcc98479a4
name: CHKB
initial amount: NaN
is encoded by: hsa:1120
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: A0PJM6
initial concentration: NaN

metaR 2OXOADPTm
fast: false
product: MODEL1310110044#
kinetic law: MODEL1310110044#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
modifier: MODEL1310110044#
reactant: MODEL1310110044#
is: SBO:0000185

metaR r2108
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110044#
fast: false
reversible: true
modifier: MODEL1310110044#
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110044#

metaR CHOLtu
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
reversible: true
name: Choline uniport
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reactant: MODEL1310110044#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR GTHRDt
name: Glutathione transport into mitochondria
fast: false
kinetic law: MODEL1310110044#
product: MODEL1310110044#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#

metaM CE2705 n
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
initial amount: NaN
has only substance units: false
is: HMDB02281
boundary condition: false
name: quinonoid dihydrobiopterin
is: CHEBI:15374
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_099b854d_d891_427f_9447_9a6e5db87a70
initial concentration: NaN
is: SBO:0000252
is: E7EUT4
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2597
initial amount: NaN
name: GAPDH

http://identifiers.org/biomodels.db/MODEL1310110044#_d892e5c4_2e9e_4e5a_85a1_e3c3a8c29db2
boundary condition: true
constant: false
name: UGT1A8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54576
has only substance units: false
is: Q5DSZ6
is: SBO:0000252
type: Species

metaR VALt5m
reversible: true
is described by: ECO:0000000
product: MODEL1310110044#
type: Reaction
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
name: Valine reversible mitochondrial transport
is: SBO:0000185
reactant: MODEL1310110044#

metaM tre e
is: HMDB00975
name: Trehalose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: CHEBI:16551
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: C01083
initial amount: NaN
is: SBO:0000247

metaM glyc3p x
type: Species
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
is: CHEBI:57597
has only substance units: false
is: HMDB00126
name: Glycerol 3-phosphate
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR C4STMO1r
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
reversible: false
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false
type: Reaction
reactant: MODEL1310110044#
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.14.13.72
is: SBO:0000176
product: MODEL1310110044#
is described by: ECO:0000000

metaM srtn e
is: SBO:0000247
is: CHEBI:350546
is: HMDB00259
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
name: serotonin(1+)
initial concentration: 1.0
initial amount: NaN

metaM gam e
is: CHEBI:17315
is: C00329
type: Species
name: D-Glucosamine
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01514
is: SBO:0000247

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000185
product: MODEL1310110044#
reversible: true

metaR r1147
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_357ee88a_3487_4b09_abcc_38f7ce943920
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:159
name: ADSS
is: P30520
type: Species
is: SBO:0000252

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_50a119ce_aa19_45bb_9b9d_2892d7781fe9
name: SLC43A1
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:8501
is: O75387
constant: false
initial concentration: NaN

metaR r2109
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
product: MODEL1310110044#
modifier: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110044#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110044#
type: Reaction

metaR DM 13 cis oretn n
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-oxo-retinoic acid demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_337fce00_866a_4193_a88f_b7ed9ab6c9d4
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q8NFW8
name: CMAS
has only substance units: false
is encoded by: hsa:55907
type: Species

metaM pail34p hs c
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57658

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_0736165c_8fe4_4ccb_8e47_d0fb83166eb4
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC26A7
boundary condition: true
is encoded by: hsa:115111
is: Q8TE54
constant: false

metaR EX pectingchol LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-glycocholate complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_67b960bc_7710_4f26_a1aa_5c32cd7409ae
constant: false
name: SLC13A5
is encoded by: hsa:284111
boundary condition: true
type: Species
is: Q86YT5
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110044#_41f3098a_74ed_4485_9670_cce0008553fe
is: P36269
constant: false
initial concentration: NaN
is encoded by: hsa:2687
is: SBO:0000252
initial amount: NaN
name: GGT5
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110044#_b51c0c8b_565f_4891_9421_a33e4c4421f9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10991
type: Species
initial concentration: NaN
boundary condition: true
is: Q99624
has only substance units: false
constant: false
name: SLC38A3

metaR HEX10
reactant: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
type: Reaction
kinetic law: MODEL1310110044#
is described by: ECO:0000212
modifier: MODEL1310110044#
product: MODEL1310110044#
name: hexokinase (D-glucosamine:ATP)
reversible: false
fast: false

metaR THYOXt2
modifier: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: T4 transport via facilitated diffusion
product: MODEL1310110044#
reversible: true
kinetic law: MODEL1310110044#
type: Reaction

metaR DRPA
type: Reaction
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110044#
reversible: false
product: MODEL1310110044#

metaM gua e
type: Species
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
is: CHEBI:16235
initial concentration: 1.0
constant: false
name: guanine
is: SBO:0000247
initial amount: NaN
is: HMDB00132

http://identifiers.org/biomodels.db/MODEL1310110044#_bf2786dc_019d_4157_8936_a57d24219f94
name: ALDH3B2
has only substance units: false
initial amount: NaN
is encoded by: hsa:222
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: P48448

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
kinetic law: MODEL1310110044#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1

metaR r1623
is: SBO:0000185
product: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110044#

metaR r1527
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
product: MODEL1310110044#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is: SBO:0000185
kinetic law: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.1
reactant: MODEL1310110044#
fast: false
reversible: false

metaR r0728
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
type: Reaction
product: MODEL1310110044#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110044#

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR DNDPt37m
reactant: MODEL1310110044#
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
name: dUTP transport via dTDP antiport
is: SBO:0000185
modifier: MODEL1310110044#

metaM dcamp c
boundary condition: false
name: N6-(1,2-Dicarboxyethyl)-AMP
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: HMDB00536
constant: false
initial amount: NaN
has only substance units: false
is: C03794
type: Species
initial concentration: 1.0
is: CHEBI:57567
is: SBO:0000247

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_71cd3442_de6c_452f_aa2a_a6b6d8e8b86c
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: O43772
has only substance units: false
name: SLC25A20
is encoded by: hsa:788
is: SBO:0000252

metaM pchol hs g
initial amount: NaN
boundary condition: false
constant: false
name: Phosphatidylcholine
initial concentration: 1.0
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
has only substance units: false
is: SBO:0000247

metaR DHFR
is described by: ECO:0000254
fast: false
product: MODEL1310110044#
reversible: true
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is: SBO:0000176
name: dihydrofolate reductase
modifier: MODEL1310110044#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:

metaR RE1523M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110044#
is described by: ECO:0000000
modifier: MODEL1310110044#
is: SBO:0000176
fast: false
product: MODEL1310110044#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: RE1523

metaM pnto R c
constant: false
is: CHEBI:7916
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
is: HMDB00210
has only substance units: false
type: Species
is: SBO:0000247

metaM gln L e
is: HMDB00641
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
is: CHEBI:18050
name: L-glutamine
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0954
type: Reaction
product: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
kinetic law: MODEL1310110044#
is described by: ECO:0000000
reactant: MODEL1310110044#
reversible: true
name: MCT 1 Transport reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_31c66968_2950_4ed6_bd5b_33dae2b6b1de
name: HK1
constant: false
has only substance units: false
is: SBO:0000252
is: B3KXY9
is encoded by: hsa:3098
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR r0267
type: Reaction
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
kinetic law: MODEL1310110044#
is version of: http://identifiers.org/ec-code/3.5.1.9
is described by: ECO:0000000
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
modifier: MODEL1310110044#
reversible: true
is: SBO:0000176
product: MODEL1310110044#
reactant: MODEL1310110044#
fast: false

metaR r1624
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110044#
fast: false
reversible: true
reactant: MODEL1310110044#
is: SBO:0000185
modifier: MODEL1310110044#
is described by: ECO:0000000
product: MODEL1310110044#

metaR FAOXC141C121x
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_10c306a6_5b58_4f2a_85f0_d678cbcde36f
initial amount: NaN
is: SBO:0000252
name: _AI373818_1_m
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:AI373818

metaM leu L e
boundary condition: false
type: Species
is: HMDB00687
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: L-leucine

metaM CE2432 m
constant: false
type: Species
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: SBO:0000247
has only substance units: false
is: CHEBI:57795
boundary condition: false

metaR MTAP
type: Reaction
product: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (4507.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
name: 5'-methylthioadenosine phosphorylase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110044#
reversible: false
modifier: MODEL1310110044#
is version of: http://identifiers.org/ec-code/2.4.2.28
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110044#_f6ccb4b4_a7a1_44ff_8366_1d22fd26635f
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:39
is: SBO:0000252
constant: false
initial concentration: NaN
name: ACAT2
is: Q9BWD1
type: Species

metaM HC02204 e
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: prostaglandin-b1
is: CHEBI:27624
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false

metaR URCN
reactant: MODEL1310110044#
name: URCN
is described by: ECO:0000269
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.49
is: SBO:0000176
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110044#_f25dfa21_d02a_4f84_90e8_9f8a522e5b59
name: ALDH9A1
initial amount: NaN
is encoded by: hsa:223
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P49189
type: Species
constant: false

metaM 5HPET c
is: HMDB01193
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
is: CHEBI:57450
name: 5(S)-HPETE(1-)
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110044#_c5b733d8_98fe_4a85_b2ac_8f0fbe301a48
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:353
initial concentration: NaN
has only substance units: false
boundary condition: true
name: APRT
type: Species
is: P07741

metaR r2031
modifier: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
is: SBO:0000185
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110044#_7b07d3ed_f0a2_4b0f_8a49_4ae9f6aff8f1
is: Q99643
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:6391
name: SDHC
has only substance units: false
type: Species

metaR GLYt4
type: Reaction
fast: false
name: glycine transport via sodium symport
reversible: false
reactant: MODEL1310110044#
is described by: ECO:0000269
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
modifier: MODEL1310110044#
product: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_af815e9c_a2cc_4080_a002_a13e8265b30d
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:1593
is: Q02318
initial amount: NaN
name: CYP27A1

metaM HC02214 c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:28852
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
type: Species
constant: false
is: SBO:0000247

metaR r2104
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110044#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110044#_64677dbe_d0d6_4a73_b3ca_e08dfcc8a56e
type: Species
constant: false
name: HMGCS1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3157
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_adfb79a4_9c89_4898_b5de_cbf47cabc0f4
boundary condition: true
name: TXNRD1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:7296
is: SBO:0000252

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110044#_f9f5621e_9f77_43b2_988c_86be1fd37fe7
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:5297
initial concentration: NaN
name: PI4KA
is: B4DYG5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_014795ca_1bd4_42dd_af90_31106e3705ce
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3028
name: HSD17B10
type: Species
boundary condition: true
is: Q99714
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_ef554112_b649_4c22_82e1_6bda15d8bc15
boundary condition: true
initial concentration: NaN
is: Q96P26
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: NT5C1B
constant: false
is encoded by: hsa:93034

http://identifiers.org/biomodels.db/MODEL1310110044#_281ddb1b_b820_4f20_9569_1dce629e5524
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: PRODH
initial amount: NaN
is encoded by: hsa:5625
is: O43272

metaR r2032
fast: false
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110044#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110044#
type: Reaction
reversible: false
reactant: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_9332fa04_7702_4426_93df_e05a19c057da
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AW299740
boundary condition: true
has only substance units: false
constant: false
type: Species
name: _AW299740_1_m

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR MAL Lte
product: MODEL1310110044#
name: Transport of L-malate
reactant: MODEL1310110044#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110044#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_13df494b_015f_4c0b_aaa5_e29c1679f92b
name: PHPT1
initial amount: NaN
is: Q9P019
constant: false
initial concentration: NaN
is encoded by: hsa:29085
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2105
type: Reaction
modifier: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR PAIL45P HStn
reactant: MODEL1310110044#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110044#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r0156
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#

metaM HC02204 c
initial concentration: 1.0
boundary condition: false
is: CHEBI:27624
initial amount: NaN
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
has only substance units: false
constant: false
name: prostaglandin-b1

metaM methf m
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
is: CHEBI:57455
initial amount: NaN
type: Species

metaR O2ter
type: Reaction
reversible: true
kinetic law: MODEL1310110044#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110044#
is described by: ECO:0000000
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110044#

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110044#
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR G3PD1
reactant: MODEL1310110044#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.8
name: glycerol-3-phosphate dehydrogenase (NAD)
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
modifier: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#

metaR r2106
fast: false
reactant: MODEL1310110044#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110044#
product: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110044#_7754fe24_2fbd_4b56_a01c_1e8e190f6fc5
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: BDH1
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:622

metaM HC02214 e
is: CHEBI:28852
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1

metaR CYANt
reversible: true
name: Cyanide transport via diffusion (extracellular to cytosol)
product: MODEL1310110044#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110044#_894b8405_2ab1_42f8_88ea_39769dbf753f
is: Q16873
has only substance units: false
initial amount: NaN
name: LTC4S
constant: false
is encoded by: hsa:4056
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaR CYOOm3
kinetic law: MODEL1310110044#
modifier: MODEL1310110044#
name: cytochrome c oxidase, mitochondrial Complex IV
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
fast: false
reactant: MODEL1310110044#
product: MODEL1310110044#
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1

http://identifiers.org/biomodels.db/MODEL1310110044#_b2951861_d9b1_47d8_99a5_44ddf6b47d84
initial concentration: NaN
type: Species
name: _AU149534_1_m
is encoded by: hsa:AU149534
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110044#_c7fc9069_f77c_4b78_bb29_4a0f7f3983d2
type: Species
boundary condition: true
is: O95498
is encoded by: hsa:8875
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: VNN2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110044#_a9d26a10_d5b6_46b2_bf3b_854aa7eed45d
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:53354
boundary condition: true
is: SBO:0000252
name: PANK1
is: Q8TE04

metaM HC01401 m
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27668
constant: false

metaR FAOXC61m
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR FADtru
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
fast: false
reversible: false
product: MODEL1310110044#
name: FAD transporter, endoplasmic reticulum
type: Reaction

metaM pchol hs c
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
name: Phosphatidylcholine

metaR PMTCOAtx
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid intracellular transport
reactant: MODEL1310110044#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110044#
fast: false
product: MODEL1310110044#
type: Reaction

metaR MTHFDm
reversible: true
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reactant: MODEL1310110044#
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial

metaR HOMt4
is: SBO:0000185
kinetic law: MODEL1310110044#
product: MODEL1310110044#
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false
modifier: MODEL1310110044#
reversible: false
is described by: ECO:0000269
name: L-homoserine via sodium symport
reactant: MODEL1310110044#
type: Reaction

metaR r2107
kinetic law: MODEL1310110044#
is: SBO:0000185
fast: false
modifier: MODEL1310110044#
reactant: MODEL1310110044#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110044#

metaM tym c
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00306
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:327995
name: tyraminium

metaR RE1516M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110044#
is described by: ECO:0000000
kinetic law: MODEL1310110044#
name: RE1516
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110044#
product: MODEL1310110044#
type: Reaction

metaR PROSTGE1t
fast: false
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
product: MODEL1310110044#
reactant: MODEL1310110044#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport

metaM 13dpg c
is: SBO:0000247
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
has only substance units: false
is: C00236
is: HMDB01270
type: Species
name: 3-Phospho-D-glyceroyl phosphate
initial concentration: 1.0
is: CHEBI:57604
boundary condition: false
constant: false

metaR r2308
fast: false
reactant: MODEL1310110044#
kinetic law: MODEL1310110044#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110044#

metaR CYOR u10m
reactant: MODEL1310110044#
type: Reaction
is: SBO:0000185
name: ubiquinol-6 cytochrome c reductase, Complex III
is described by: ECO:0000134
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
fast: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
product: MODEL1310110044#

http://identifiers.org/biomodels.db/MODEL1310110044#_c59e0170_34c2_4f35_8c53_38edab3d74ec
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:D29675
name: _D29675_1_c
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1620
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110044#
type: Reaction
product: MODEL1310110044#
modifier: MODEL1310110044#
kinetic law: MODEL1310110044#
reversible: true

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
type: Species
is: C00101
constant: false
is: CHEBI:57453
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01846

metaM tdcoa c
is: SBO:0000247
boundary condition: false
is: HMDB01521
is: CHEBI:57385
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM malthx e
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: C01936
initial amount: NaN
constant: false
name: Maltohexaose
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041

metaR r0157
reactant: MODEL1310110044#
product: MODEL1310110044#
modifier: MODEL1310110044#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110044#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.2
type: Reaction