metaM ksi pre2 g
constant: false
is: CHEBI:58053
type: Species
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 2
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00175
boundary condition: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110043#_6795bcd9_05fd_4997_ad77_46c55252592c
type: Species
is: P07451
name: CA3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:761
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaM acgam1p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
name: N-Acetyl-D-glucosamine 1-phosphate
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:7125
constant: false
has only substance units: false
type: Species
is: HMDB01367
initial concentration: 1.0

metaM acnam l
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00230
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
boundary condition: false
name: N-acetylneuraminate
is: CHEBI:35418
type: Species
has only substance units: false

metaM leuktrB4 e
type: Species
constant: false
is: CHEBI:57461
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01085

metaR C226CPT2
name: C226 transport into the mitochondria
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaR VACCCPT1
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
type: Reaction
is described by: ECO:0000000
name: carnitine O-palmitoyltransferase

metaR r0753
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
is: SBO:0000176
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR C226CPT1
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
name: carnitine C22:6 transferase
reversible: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is described by: ECO:0000000

metaR KSII CORE2tly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
reversible: false
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is: SBO:0000185
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#

metaR NACASPAH
modifier: MODEL1310110043#
is described by: ECO:0000269
name: N-Acetyl-L-aspartate amidohydrolase
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.1.15
reversible: false
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
fast: false

metaR r1638
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110043#

metaR ITPtn
fast: false
name: ITP nuclear transport
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185

metaM pmtcrn x
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial amount: NaN
name: L-palmitoylcarnitine
is: CHEBI:17490
boundary condition: false
is: HMDB00222
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR O2ter
reversible: true
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
name: O2 transport, endoplasmic reticulum
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_19c1396b_ed00_4fca_94ed_54f6601a9473
is encoded by: hsa:5198
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: Q6P4B4
has only substance units: false
name: PFAS

metaM c8crn c
boundary condition: false
type: Species
is: SBO:0000247
name: octanoyl carnitine
is: HMDB00791
initial concentration: 1.0
notes: FORMULA: C15H29NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: C02838
constant: false

metaR NACHEX2ly
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110043#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR L LACt4r
is described by: ECO:0000000
name: L-lactate reversible transport via sodium symport
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

metaR FAOXC163C164x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaM ksii core4 pre5 g
is: C00130
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
initial amount: NaN
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaM xol7aone m
is: SBO:0000247
constant: false
type: Species
is: CHEBI:17899
is: HMDB01993
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

http://identifiers.org/biomodels.db/MODEL1310110043#_cf295b2f_7af9_474c_98ef_fefa9c1e6ad1
constant: false
is encoded by: hsa:10637
name: LEFTY1
type: Species
is: SBO:0000252
is: O75610
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR ELAIDCPT1
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR DOLPGT3 Uer
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.256
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (84920.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
fast: false
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_15bf547c_56f1_41c9_9668_bad0d3c46589
is encoded by: hsa:5279
has only substance units: false
name: PIGC
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: Q92535
is: SBO:0000252
initial amount: NaN

metaR r0752
is: SBO:0000176
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reversible: true

metaR FAOXC141C141OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_fe0ffce1_7f75_42e1_9754_923fa47e74ff
is encoded by: hsa:204
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: P54819
initial amount: NaN
name: AK2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_f61a21ff_7182_44f2_b22d_d771ba8ddc3a
name: TPH1
is: SBO:0000252
initial amount: NaN
is: P17752
is encoded by: hsa:7166
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM urea e
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
name: Urea
type: Species
initial concentration: 1.0
is: C00086
boundary condition: false
has only substance units: false
is: CHEBI:16199
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00294

metaM tdcrn e
constant: false
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: myristoyl carnitine
has only substance units: false
is: HMDB05066

metaR 3AIBt
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
name: 3-amino-isobutyrate transport
fast: false

metaR r1637
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#
is: SBO:0000185

metaR VACCCPT2
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: carnitine transferase
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false

metaR PIter
type: Reaction
fast: false
kinetic law: MODEL1310110043#
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
is described by: ECO:0000212

metaR CERT1gt
modifier: MODEL1310110043#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is: SBO:0000185
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000304
product: MODEL1310110043#

metaM 5aizc c
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
initial amount: NaN
is: SBO:0000247
is: CHEBI:58564
constant: false
type: Species
is: HMDB06273
is: C04751
has only substance units: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
initial concentration: 1.0
boundary condition: false

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ea1f479c_06dd_49e8_a3fd_63b63babbede
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: NNT
type: Species
has only substance units: false
is encoded by: hsa:23530

metaM nrpphr c
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:33569
constant: false
initial amount: NaN
name: Norepinephrine
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial concentration: 1.0
is: HMDB00216

http://identifiers.org/biomodels.db/MODEL1310110043#_db6999a6_c93e_45f3_8968_0fde03835ae2
is: SBO:0000252
is: O14832
constant: false
name: PHYH
has only substance units: false
is encoded by: hsa:5264
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR PACCOAL
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
name: phenylacetate-CoA ligase
is described by: ECO:0000000
reactant: MODEL1310110043#

metaR FAOXC61C4m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR GTHDH
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
name: Glutathione dehydrogenase (dehydroascorbate reductase)

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM T4hcinnm m
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
is: CHEBI:12876
is: HMDB02035
name: trans-4-coumarate
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_2cf37658_4414_4e65_9280_91d6cdfec490
boundary condition: true
initial amount: NaN
is encoded by: hsa:116369
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: SLC26A8

metaM CE2915 e
initial amount: NaN
type: Species
constant: false
name: beta-casomorphin
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
notes: FORMULA: C44H60N7O11 CHARGE: -1 INCHI: InChI=1/C44H61N7O11/c1-5-26(4)37(44(61)62)49-40(57)34-14-10-22-51(34)43(60)31(19-20-35(53)54)46-41(58)36(25(2)3)48-38(55)32(24-27-11-7-6-8-12-27)47-39(56)33-13-9-21-50(33)42(59)30(45)23-28-15-17-29(52)18-16-28/h6-8,11-12,15-18,25-26,30-34,36-37,52H,5,9-10,13-14,19-24,45H2,1-4H3,(H,46,58)(H,47,56)(H,48,55)(H,49,57)(H,53,54)(H,61,62)/p-1/t26-,30-,31+,32+,33-,34+,36-,37-/m1/s1 EHMN_ABBREVIATION: CE2915
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C01936

metaR r0755
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaR FAOXC24C22x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaR S6TASE26ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is: SBO:0000176
reversible: true

metaM crn m
is: HMDB00062
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false
is: C00318
type: Species
is: CHEBI:16347
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_1ef1fc6a_ed9f_4052_a013_4ac46ee0b581
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: P36542
has only substance units: false
name: ATP5C1
is encoded by: hsa:509
is: SBO:0000252
boundary condition: true

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR r1636
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110043#
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR PYNP2r
is: SBO:0000176
name: pyrimidine-nucleoside phosphorylase (uracil)
type: Reaction
is described by: ECO:0000269
product: MODEL1310110043#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR TETPENT3t
fast: false
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: fatty acid transport via diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_53910dbf_81a1_475a_a36b_4124611956b9
is encoded by: hsa:8818
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:54344
initial concentration: NaN
is: SBO:0000297
name: DPM3:DPM1:DPM2
has only substance units: false
has part: Q9P2X0
constant: false

metaM c8crn e
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00791
name: octanoyl carnitine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C15H29NO4 CHARGE: 0
is: C02838
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b9b18c41_c699_40cb_a2de_e2241ff2d3cc
has only substance units: false
type: Species
name: PDE9A
is encoded by: hsa:5152
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR KYNATESYN
fast: false
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_a24b1e79_d92e_41eb_9c26_4c6a6b114121
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: Q8TF08
name: COX7B2
is encoded by: hsa:170712
boundary condition: true
is: SBO:0000252
constant: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_6384bf2f_210a_41a4_8749_22468f0a5158
constant: false
is encoded by: hsa:7001
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PRDX2
has only substance units: false

metaR r0754
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176

metaM ksii core4 e
constant: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 4-linked)
is: CHEBI:17268
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00211
type: Species

metaR URIK1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
modifier: MODEL1310110043#
name: uridine kinase (ATP:Uridine)
reactant: MODEL1310110043#
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
product: MODEL1310110043#

metaR C8DCc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaM tdcrn c
type: Species
initial concentration: 1.0
notes: FORMULA: C21H41NO4 CHARGE: 0
is: HMDB05066
is: SBO:0000247
name: myristoyl carnitine
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

metaM f26bp c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58579
is: HMDB01047
type: Species
constant: false
boundary condition: false
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
has only substance units: false

metaR GLCAASE4ly
name: beta-glucuronidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
reversible: false
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110043#

metaM CE2705 n
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
is: HMDB02281
is: SBO:0000247
is: CHEBI:15374
name: quinonoid dihydrobiopterin

metaR r1635
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_baa80ff6_89d3_4d18_bb11_823872c618c4
is encoded by: hsa:108
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ADCY2
constant: false
is: Q71UM8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_53af71e6_c5c1_4fa8_b2da_d0903bdfa915
is: SBO:0000252
constant: false
name: GATM
is: P50440
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2628
has only substance units: false
type: Species

metaM urea c
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
has only substance units: false
name: Urea
initial concentration: 1.0
boundary condition: false
type: Species
is: C00086
is: CHEBI:16199
initial amount: NaN
is: SBO:0000247
is: HMDB00294
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_dd4f8952_0b86_48f1_a031_896419a6f130
boundary condition: true
is encoded by: hsa:4329
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q02252
constant: false
has only substance units: false
name: ALDH6A1

metaR PI345P3P
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is described by: ECO:0000000
reversible: false

metaM cs a deg3 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
is: CHEBI:15748
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00127
type: Species
initial amount: NaN
notes: FORMULA: C31H48NO32S2 CHARGE: -3

metaR FAOXC2031836m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
name: Beta oxidation of fatty acid
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110043#_723fd015_6de2_4598_822b_790019fb3394
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: P53004
is encoded by: hsa:644
is: SBO:0000252
name: BLVRA

metaR r0142
product: MODEL1310110043#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reactant: MODEL1310110043#
fast: false

metaM dolmanp U c
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
constant: false
is: CHEBI:15809
boundary condition: false
has only substance units: false
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM nrpphr e
constant: false
initial amount: NaN
is: CHEBI:33569
is: SBO:0000247
boundary condition: false
name: Norepinephrine
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
initial concentration: 1.0
is: HMDB00216

metaR RTOTAL2t
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: true
reactant: MODEL1310110043#
fast: false
name: RTOTAL2 transport
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaM ser D c
is: CHEBI:16523
is: HMDB03406
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false
initial concentration: 1.0
name: D-serine
is: SBO:0000247
type: Species

metaR ARGt4
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
is: SBO:0000185
name: L-arginine transport in via sodium symport
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false

metaR r1634
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_96d9cddd_9cdc_4770_bbc1_2a14506ce143
constant: false
boundary condition: true
is encoded by: hsa:52
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P24666
name: ACP1

metaR r2408
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110043#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false

metaR PTDCACRNCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
fast: false
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
name: carnitine fatty-acyl transferase
is described by: ECO:0000269

metaR PRISTCOAtcx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8125d3d3_add3_41c9_ad3f_c03f8304d91b
name: AGPAT4
constant: false
is encoded by: hsa:56895
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NRZ5
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_f12ef4a1_d785_49b0_a420_4851605a2411
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4967
name: OGDH
type: Species
boundary condition: true
initial concentration: NaN
is: Q02218
has only substance units: false

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM kynate c
is: HMDB00715
type: Species
has only substance units: false
name: kynurenate
initial concentration: 1.0
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
boundary condition: false
is: CHEBI:58454
constant: false
initial amount: NaN
is: SBO:0000247

metaM c10crn c
initial concentration: 1.0
name: decanoyl carnitine
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C17H33NO4 CHARGE: 0
has only substance units: false
boundary condition: false
is: HMDB00651
constant: false

metaM hx2coa x
has only substance units: false
initial amount: NaN
name: trans-Hex-2-enoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB06870
type: Species
is: SBO:0000247
boundary condition: false
is: C05998
constant: false
is: http://identifiers.org/pubchem.compound/11966188

metaR NDP10ex
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110043#
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT

metaR HISSNAT5tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8c180c24_907b_497f_a4ac_aec4ddc866d0
is: Q96QD8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54407
type: Species
name: SLC38A2
constant: false
initial amount: NaN

metaR EX 3ivcrn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR C160CRNt
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
is described by: ECO:0000269
name: C160 transport into the mitochondria
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV

metaR r1633
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksii core4 g
name: keratan sulfate II (core 4-linked)
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17140
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
is: HMDB01644

metaR G14T14g
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110043#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
modifier: MODEL1310110043#

metaR HPDCACRNt
modifier: MODEL1310110043#
name: heptadecanoate transport into the mitochondria
is described by: ECO:0000269
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_1263c570_248a_4a8c_841f_959f6d966631
boundary condition: true
constant: false
type: Species
is: Q16706
is encoded by: hsa:4124
name: MAN2A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR LINOFATPtc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ea4cbab2_dd76_4653_a4e2_0ffebfd2abaa
type: Species
is encoded by: hsa:126328
constant: false
initial concentration: NaN
name: NDUFA11
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is: C9JT23

metaR r1632
reactant: MODEL1310110043#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction

metaR S6T11g
is described by: ECO:0000000
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR RE0926E
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
name: RE0926
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is described by: ECO:0000000

metaM ser D e
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
initial concentration: 1.0
type: Species
name: D-serine
is: HMDB03406
is: CHEBI:16523

metaR ELAIDCPT2
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
name: carnitine transferase
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110043#
type: Reaction

metaM pmtcrn r
is: HMDB00222
name: L-palmitoylcarnitine
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_40266702_ecda_4210_b1d9_a9a6e9db9367
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: GOT2
initial amount: NaN
constant: false
is: P00505
is encoded by: hsa:2806
has only substance units: false

metaR r2406
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR SMPD4
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: false
name: sphingomyelinase
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
product: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_817b8e69_4799_4a0c_98a1_885ed4fce2c1
has only substance units: false
name: _H77542_1_r
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:H77542
boundary condition: true
constant: false

metaR IDOURtly
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
product: MODEL1310110043#
reversible: true
modifier: MODEL1310110043#
type: Reaction
name: iduronate transport into lysososme
reactant: MODEL1310110043#

metaR SERPT
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000269
product: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
name: serine C-palmitoyltransferase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_c1e2966f_c290_44c2_b48c_ba58bd57607a
is: SBO:0000252
is: Q7GXZ4
name: ND4L
boundary condition: true
initial amount: NaN
is encoded by: hsa:4539
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR EX apnnox LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Pinene-oxide exchange
type: Reaction

metaR r1631
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110043#

MODEL1310110043
species: metaM mmcoa R m
species: metaM udp n
reaction: metaR AIRCr
reaction: metaR EX tetpent6 LPAREN e RPAREN
reaction: metaR EX succ LPAREN e RPAREN
species: metaM ascb L c
reaction: metaR EX CE2838 LPAREN e RPAREN
species: metaM CE5869 e
species: metaM thmpp m
species: metaM Rtotal e
reaction: metaR FAOXTC101TC102m
species: metaM 2ddecdicoa x
reaction: metaR FAOXC80
species: metaM dcacoa x
species: metaM acetone e
species: metaM atp r
species: metaM dcdp c
species: metaM HC02210 c
species: metaM srtn c
reaction: metaR EX cspg e LPAREN e RPAREN
reaction: metaR r1740
reaction: metaR r2321
reaction: metaR LYStip
reaction: metaR 4NPHte
species: metaM tsul c
species: metaM mma c
reaction: metaR EX tdchola LPAREN e RPAREN
reaction: metaR NH4tp
reaction: metaR HSD17B9r
species: metaM prostgi2 r
reaction: metaR EX but LPAREN e RPAREN
reaction: metaR EX ade LPAREN e RPAREN
reaction: metaR DECDPtm
reaction: metaR RE0830N
reaction: metaR PPItr
reaction: metaR HTDCACBP
reaction: metaR S6T3g
species: metaM 5mthf e
species: metaM dca c
species: metaM g1m8mpdol U r
reaction: metaR r1050
species: metaM 3tetd7ecoacrn e
species: metaM hdca l
reaction: metaR STS2
species: metaM val L c
reaction: metaR EX dcsptn1 LPAREN e RPAREN
reaction: metaR RE0915E
species: metaM 2oxoadp c
reaction: metaR r0706
species: metaM ocde9ecoa x
reaction: metaR r2443
reaction: metaR VACCCPT1
species: metaM acrn c
species: metaM lneldccrn m
species: metaM dd2coa c
reaction: metaR CRNtim
species: metaM HC01104 e
reaction: metaR EX CE4722 LPAREN e RPAREN
species: metaM h2o2 c
reaction: metaR EX glysar LPAREN e RPAREN
species: metaM gua c
reaction: metaR SADT
reaction: metaR AG13T14g
reaction: metaR r2537
species: metaM CE2421 m
species: metaM fuc12gal14acglcgalgluside hs g
species: metaM duri e
reaction: metaR B3GNT12g
species: metaM 2mb2coa c
reaction: metaR r0170
species: metaM HC01444 e
reaction: metaR AMPTASECGe
species: metaM 3mop c
species: metaM phe L e
species: metaM 5mta c
species: metaM glc D e
reaction: metaR FAOXC164m
reaction: metaR MGCHrm
reaction: metaR AHCYStr
reaction: metaR ATPtx

metaR r0145
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.8.3.1
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
reversible: true

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2e70f896_495a_46dc_a473_406da1e38eaa
constant: false
is encoded by: hsa:4709
boundary condition: true
type: Species
initial amount: NaN
is: Q6IB80
is: SBO:0000252
name: NDUFB3
has only substance units: false
initial concentration: NaN

metaM ttdcrn c
name: tetradecanoyl carnitine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: http://identifiers.org/pubchem.compound/3413344
has only substance units: false
is: HMDB05066
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR r0750
is described by: ECO:0000000
type: Reaction
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM crn r
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16347
is: HMDB00062
name: (R)-carnitine
initial concentration: 1.0
constant: false
has only substance units: false

metaR ACETONEt2m
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: acetone mitochondrial transport via proton symport
modifier: MODEL1310110043#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7ec8f59e_d187_4d4b_97a7_92f50975a5da
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7086
is: E7EPA7
has only substance units: false
name: TKT

http://identifiers.org/biomodels.db/MODEL1310110043#_02e53d80_f902_4aa8_b217_51b9eb90f772
is encoded by: hsa:9551
is encoded by: hsa:516
has part: O75964
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
has only substance units: false
is encoded by: hsa:4905
is encoded by: hsa:10476
type: Species
has part: Q6IBB3
has part: P56385
has part: Q08ET0
is encoded by: hsa:521
constant: false
has part: P46459
has part: P05496
is encoded by: hsa:515
is encoded by: hsa:10632
is encoded by: hsa:522
initial concentration: NaN
has part: A0PJH2
boundary condition: true
initial amount: NaN

metaR GALASE6ly
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176

metaM HC02217 c
initial concentration: 1.0
name: prostaglandin-g2
is: CHEBI:27647
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false

metaM 9 cis retfa e
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06559
name: fatty acid 9-cis-retinol
constant: false
type: Species
initial amount: NaN

metaR CYSALANaEx
reversible: false
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110043#
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR GRTTx
is: SBO:0000176
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000134
name: geranyltranstransferase
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#

metaR SUCCTD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM retinal 11 cis c
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
boundary condition: false
is: HMDB02152
name: 11-cis-retinal
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16066

metaM co2 c
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0
initial concentration: 1.0
type: Species
constant: false
is: C00011
is: CHEBI:3313
is: HMDB01967
boundary condition: false
is: SBO:0000247
has only substance units: false
name: CO2

metaM cmp c
initial amount: NaN
initial concentration: 1.0
type: Species
is: C00055
constant: false
is: HMDB00095
boundary condition: false
is: SBO:0000247
has only substance units: false
name: CMP
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377

http://identifiers.org/biomodels.db/MODEL1310110043#_eafbe5f1_3ca0_46c1_94b6_437f55f16bb1
name: MAN1C1
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9NR34
is encoded by: hsa:57134
has only substance units: false

metaR PTE4x
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
name: peroxisomal acyl-CoA thioesterase
reversible: false
kinetic law: MODEL1310110043#
is described by: ECO:0000269
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#

metaR FAOXC18280m
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
name: Beta oxidation of fatty acid
modifier: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_dcb806fd_dbda_480f_896c_238c47aad313
is encoded by: hsa:4598
is: B2RDU6
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: MVK
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9f866787_8ca7_41eb_b630_0c3f8880d1c4
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AA788780
initial concentration: NaN
initial amount: NaN
name: _AA788780_1_c
boundary condition: true
has only substance units: false

metaR C4CRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR FK
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.52
reversible: false
reactant: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is described by: ECO:0000000
type: Reaction
name: Fucokinase
fast: false

metaR MCCCrm
modifier: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.4
name: methylcrotonoyl-CoA carboxylase, mitochondrial
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000269

metaM 10fthf5glu e
boundary condition: false
is: CHEBI:57454
has only substance units: false
is: HMDB00972
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6

metaM ttdcrn m
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3413344
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
name: tetradecanoyl carnitine
is: HMDB05066
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM crn c
is: HMDB00062
initial amount: NaN
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
has only substance units: false
constant: false
name: L-Carnitine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16347
type: Species

metaM ribflv e
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00255
is: HMDB00244
is: CHEBI:3554
type: Species
name: Riboflavin
constant: false

metaR T4HCINNMFM
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
name: 4-hydroxycinnamate formation
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_639cd4bc_a7aa_4348_af6f_ecd4fddace4d
initial amount: NaN
boundary condition: true
name: HSD11B1
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3290
constant: false

metaM Rtotal2 e
initial amount: NaN
constant: false
boundary condition: false
name: R total 2 position
initial concentration: 1.0
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00244
is: C00255
is: CHEBI:3554
has only substance units: false
is: SBO:0000247
type: Species

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM alpa hs c
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
boundary condition: false
name: lysophosphatidic acid
is: CHEBI:52288
is: SBO:0000247
type: Species
has only substance units: false

metaR RBK
type: Reaction
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
is: SBO:0000176
name: ribokinase
is version of: http://identifiers.org/ec-code/2.7.1.15
modifier: MODEL1310110043#

metaM taur e
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00251
name: Taurine
is: CHEBI:3544
initial concentration: 1.0
is: C00245
constant: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110043#_afc3ea5a_e23a_4790_bec5_9a95bc741f78
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: P02730
initial amount: NaN
type: Species
name: SLC4A1
is: SBO:0000252
is encoded by: hsa:6521

metaM HC00361 c
is: CHEBI:58335
initial concentration: 1.0
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447

http://identifiers.org/biomodels.db/MODEL1310110043#_05e7cf24_30de_4642_8d85_2d02f3b8af8f
is: P12074
is encoded by: hsa:1337
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: COX6A1
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR RE1520M
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: RE1520
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: true

metaM hexdicoa c
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: hexadecanedioylcoa
initial concentration: 1.0
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
constant: false
has only substance units: false
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110043#_a74f83b9_2adb_4ef5_96bd_292c112dbf88
initial concentration: NaN
has only substance units: false
type: Species
name: ABAT
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:18

http://identifiers.org/biomodels.db/MODEL1310110043#_d0e44c8d_2fd6_4d82_9a17_cba882ee25e6
is encoded by: hsa:1375
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q92523
is: SBO:0000252
type: Species
name: CPT1B
constant: false

metaR XYLtly
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
name: Xylose efflux from lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110043#
reversible: false

metaR 3DSPHR
modifier: MODEL1310110043#
is described by: ECO:0000269
name: 3-Dehydrosphinganine reductase
is version of: http://identifiers.org/ec-code/1.1.1.102
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110043#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110043#

metaM HC02217 e
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: prostaglandin-g2
type: Species
is: SBO:0000247

metaR r1375
reversible: false
name: Transport reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR PCHOLP hs
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
is described by: ECO:0000269
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: choline phosphatase
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_30cb9e6e_daf0_469d_827a_659bebae70ba
boundary condition: true
is: P23434
has only substance units: false
name: GCSH
type: Species
is encoded by: hsa:2653
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GLXtp
fast: false
name: glyoxylate transport, peroxisomal
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110043#
reversible: true
is: SBO:0000185

metaR ACACT7p
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110043#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_821ee367_1e7e_4138_8ed5_c03f1b5c0191
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: GSTZ1
constant: false
is: O43708
is encoded by: hsa:2954
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_f899bb54_587f_4375_a122_35f3ffd1b557
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3141
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P50747
name: HLCS
type: Species

metaM ocdcea c
is: C00712
is: CHEBI:0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00207
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1

metaM dolmanp U r
name: Dolichyl phosphate D-mannose, human uterine homolog
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
is: CHEBI:15809
initial concentration: 1.0
boundary condition: false

metaR PTDCACRNCPT2
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: pentadecanoate transport into the mitochondria
product: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_aeceb55d_67c3_49e0_82a5_6c1f9e66b4a7
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: VNN3
is encoded by: hsa:55350

metaR r0149
is: SBO:0000176
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction

metaR HXPRT
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
type: Reaction
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
fast: false
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269

metaR r1374
kinetic law: MODEL1310110043#
name: EC:3.2.1.14
reversible: false
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
type: Reaction
is: SBO:0000176
fast: false

metaM crn e
is: HMDB00062
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00318
name: L-Carnitine
is: CHEBI:16347
type: Species
constant: false
initial concentration: 1.0

metaM ribflv c
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00255
is: HMDB00244
name: Riboflavin
is: CHEBI:3554
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false

metaR EX appnn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (+)-alpha-Pinene exchange
type: Reaction

metaM Rtotal2 c
is: HMDB01564
name: R total 2 position
initial amount: NaN
is: CHEBI:57876
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false

metaR THBPT4ACAMDASE
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
reversible: false
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
modifier: MODEL1310110043#

metaR r1377
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

metaM 4hbzcoa m
initial amount: NaN
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 4-hydroxybenoyl-CoA
is: HMDB06467
constant: false

metaR C161CRNt
reversible: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
name: C161 transport into the mitochondria
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV

metaM cala c
name: N-carbamoyl-beta-alaninate
is: CHEBI:11892
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB00026
initial amount: NaN
initial concentration: 1.0

metaR FAOXC226m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM sphmyln hs g
name: sphingomyelin betaine
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:58216
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM cmp g
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
type: Species
constant: false
name: CMP(2-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:60377

metaR ECOAH9m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110043#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial

metaR ALASERNaEx
kinetic law: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
fast: false
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)

metaM hxcoa c
has only substance units: false
initial concentration: 1.0
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: HMDB13130
is: SBO:0000247

metaR 2MB2COAc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaR CSPG Atly
product: MODEL1310110043#
reactant: MODEL1310110043#
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110043#
type: Reaction

metaR RE0937E
kinetic law: MODEL1310110043#
name: RE0937
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.17.23

metaR ACGPID
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.1.89
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD

metaM ocdcea e
has only substance units: false
is: HMDB00207
constant: false
boundary condition: false
name: octadecenoate (n-C18:1)
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
is: C00712

metaR FAOXC16BRx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_68d996e3_a02e_427c_9347_513df001d7c8
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: PDE1A
initial amount: NaN
is encoded by: hsa:5136
is: Q9Y633
constant: false
has only substance units: false

metaR ALDD2y
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_95991906_dd72_48ee_bda0_b7dc7731e951
is: Q92536
has only substance units: false
is: SBO:0000252
constant: false
name: SLC7A6
type: Species
initial concentration: NaN
is encoded by: hsa:9057
initial amount: NaN
boundary condition: true

metaM lac L x
is: SBO:0000247
name: (S)-lactate
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: HMDB00190
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_23406ec6_e44d_43f9_beaa_087bd61a32b9
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC6A8
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6535
is: B4DIA3
boundary condition: true

metaR AG13T4g
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9e75a37e_8f44_4e88_ba1f_54b480ccdbf2
type: Species
boundary condition: true
name: NME1:NME2
is encoded by: hsa:4830
constant: false
is: SBO:0000297
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR FUT14g
product: MODEL1310110043#
name: Galactoside 2-alpha-L-fucosyltransferase 1
is: SBO:0000176
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction

metaM ksi pre24 g
type: Species
is: CHEBI:58053
constant: false
initial amount: NaN
is: HMDB00175
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
boundary condition: false
is: SBO:0000247
is: C00130
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 24

metaR SARDHm
is described by: ECO:0000269
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
reactant: MODEL1310110043#
name: Sarcosine dehydrogenase (m)
fast: false
reversible: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.99.1
modifier: MODEL1310110043#

metaR r1527
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
fast: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110043#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR ACHEe
name: Acetylcholinesterase
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.7
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ

metaR FAOXC163C143m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaR ALDD2x
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is: SBO:0000176
modifier: MODEL1310110043#
fast: false

metaR DM gncore2 g
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_9e18f7bd_64e2_4ab9_8931_d1b649c97d57
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q86YB7
initial amount: NaN
has only substance units: false
name: ECHDC2
type: Species
boundary condition: true
is encoded by: hsa:55268

metaR r2511
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110043#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110043#_4f496beb_c14a_4110_a616_26ca88a60765
type: Species
name: NME1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4830
has only substance units: false
boundary condition: true
is: P15531
constant: false
is: SBO:0000252

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8acdf091_32d8_4b78_8319_ca24f67efbc2
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:36
is: SBO:0000252
is: P45954
initial concentration: NaN
constant: false
name: ACADSB
initial amount: NaN

metaR S2TASE3ly
type: Reaction
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176

metaM acnam n
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
initial concentration: 1.0
name: N-acetylneuraminate
initial amount: NaN
is: CHEBI:35418
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00230

metaM co2 e
name: CO2
constant: false
is: C00011
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16526

metaM cmp e
constant: false
is: HMDB00095
initial concentration: 1.0
is: SBO:0000247
name: CMP(2-)
is: CHEBI:60377
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

http://identifiers.org/biomodels.db/MODEL1310110043#_6c2d5b76_3838_4418_af05_86566e42feae
type: Species
constant: false
boundary condition: true
is: Q16760
initial concentration: NaN
name: DGKD
is encoded by: hsa:8527
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_c6e67e01_967b_4736_835b_f1d788cab93b
initial amount: NaN
constant: false
name: ST3GAL3
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6487
initial concentration: NaN
is: SBO:0000252

metaR LGNCt
is: SBO:0000185
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110043#

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM Tn antigen l
is: SBO:0000247
is: C04383
has only substance units: false
name: Tn antigen
initial amount: NaN
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
boundary condition: false
constant: false

metaR r1378
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
fast: false
product: MODEL1310110043#
reversible: true
is: SBO:0000176
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284

metaR r0758
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110043#
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:

metaM gdpmann c
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
type: Species
constant: false
boundary condition: false
is: CHEBI:57527
is: SBO:0000247
initial concentration: 1.0
is: HMDB01163
has only substance units: false

metaR r1639
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

metaR GDPFUCtg
name: GDPFuc Golgi transport via CMP antiport
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
modifier: MODEL1310110043#
type: Reaction
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_8594bf93_f313_4ff3_85bb_584455b9f98b
name: HK1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: A8K7J7
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098

metaM sphmyln hs c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
type: Species
name: sphingomyelin betaine
is: CHEBI:58216
constant: false
has only substance units: false

metaR ACHtn
reversible: true
name: Acetylcholin transport, nuclear trhough pores
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3e560b47_496b_450a_9d63_c3a9518769f3
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:2645
initial concentration: NaN
name: GCK
type: Species

metaR RE3269C
is: SBO:0000176
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110043#
name: RE3269
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.3.48
kinetic law: MODEL1310110043#

metaR TMDPK
is: SBO:0000176
kinetic law: MODEL1310110043#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
product: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110043#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.2

metaR NACHEXA14ly
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110043#
reversible: false
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM hdd2crn c
is: SBO:0000247
is: HMDB06317
type: Species
name: trans-Hexadec-2-enoyl carnitine
constant: false
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM gpail hs c
boundary condition: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
is: CHEBI:17049
initial amount: NaN
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaR GLCURtly
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
product: MODEL1310110043#
name: glucuronate transport into lysososme

metaR CRNtx
reactant: MODEL1310110043#
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
fast: false
type: Reaction
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9759340d_1dda_403b_a54b_8334977818da
has only substance units: false
boundary condition: true
is: P17707
initial concentration: NaN
is encoded by: hsa:262
name: AMD1
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR FACOAL200
is described by: ECO:0000269
fast: false
name: fatty-acid--CoA ligase
reversible: true
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#

metaR CTPtn
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
name: CTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_fe3f3780_c5cc_4f11_bd81_b8080bfa93af
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: P39877
is encoded by: hsa:5322
name: PLA2G5
initial amount: NaN

metaM ocdca e
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629
is: C01530
name: octadecanoate (n-C18:0)
type: Species
initial concentration: 1.0

metaM 5homeprazole e
is: CHEBI:350546
is: HMDB00259
has only substance units: false
type: Species
name: 5 hydroxy omeprazole
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C17H19N3O4S CHARGE: 0
constant: false
initial amount: NaN

metaM lac L c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:16651
is: HMDB00190
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_8e33bc34_ad8f_46d5_9db7_af8d4f4af6c9
boundary condition: true
is encoded by: hsa:D87002
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _D87002_1_m
type: Species
constant: false
is: SBO:0000252

metaM apoC m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Apocarboxlase (no lys residue)
is: HMDB00182
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: XH CHARGE: 0
is: CHEBI:32551

metaR NAt5
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
name: sodium/ammonium proton antiporter
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6548.1) or (6550.1) or (6549.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:8199403,PMID:8595899 NOTES:NCD
kinetic law: MODEL1310110043#

metaR r2516
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:

metaM 7dhf e
type: Species
boundary condition: false
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: HMDB06559
has only substance units: false
is: SBO:0000247

metaR FAOXC16080m
is: SBO:0000176
reactant: MODEL1310110043#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
product: MODEL1310110043#
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110043#_bb2b3c1b_74cf_420a_beb8_cb726e7d640b
is: SBO:0000252
initial concentration: NaN
name: PEMT
initial amount: NaN
constant: false
is encoded by: hsa:10400
has only substance units: false
type: Species
boundary condition: true

metaM xylu L c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17399
type: Species
is: SBO:0000247
name: L-xylulose
initial concentration: 1.0
is: HMDB00751

metaM so4 e
is: CHEBI:16189
is: SBO:0000247
boundary condition: false
is: HMDB01448
has only substance units: false
initial amount: NaN
name: sulfate
type: Species
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false

metaR FAOXC226205x
kinetic law: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110043#
name: Beta oxidation of long chain fatty acid
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_6e232ea8_4b71_46cc_9f8e_77a0962ffe67
initial concentration: NaN
is: Q53HM1
type: Species
name: UCKL1
is encoded by: hsa:54963
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaR FATP6t
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110043#

metaR GLYSARCNc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM ac c
boundary condition: false
initial amount: NaN
name: acetate
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
has only substance units: false
type: Species
is: HMDB00042

metaM btn e
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
initial concentration: 1.0
is: HMDB00030
constant: false
name: Biotin
boundary condition: false
is: C00120
is: SBO:0000247
initial amount: NaN
type: Species

metaR FAOXC101C8x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaM Lpipecol x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-pipecolic acid
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: HMDB00716
is: CHEBI:30913
type: Species

metaR CSNt
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
name: cytosine transport via facilated diffusion
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_4bf9b8c1_fcce_46e9_b74f_b74fa43a5e51
initial amount: NaN
name: PANK2
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80025
constant: false

metaR CRNrtx
is described by: ECO:0000134
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
is: SBO:0000185
type: Reaction
reversible: true

metaR METS
fast: false
modifier: MODEL1310110043#
name: methionine synthase
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.1.13
reversible: false
reactant: MODEL1310110043#

metaM man c
has only substance units: false
initial amount: NaN
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
is: SBO:0000247
is: HMDB00169
name: D-Mannose
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

metaR DURAD2
is described by: ECO:0000269
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: dihydrothymin dehydrogenase (NADP)

http://identifiers.org/biomodels.db/MODEL1310110043#_577508f1_59fd_4978_8e2a_c1f0abcd46ca
boundary condition: true
has only substance units: false
is encoded by: hsa:AI934540
initial concentration: NaN
is: SBO:0000252
name: _AI934540_1_c
initial amount: NaN
constant: false
type: Species

metaM HC00695 m
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17432
is: SBO:0000247
name: S-Succinyldihydrolipoamide
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
boundary condition: false

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
name: Tn antigen
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C04383

metaM 3uib c
type: Species
boundary condition: false
name: 3-Ureidoisobutyrate
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:1670
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
is: HMDB02031

http://identifiers.org/biomodels.db/MODEL1310110043#_1ad1b1fb_26db_4ecd_ab65_07b538ca873d
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:10678
name: B3GNT2

metaR CRNCARtp
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110043#
name: carnitine-acetylcarnitine carrier, peroxisomal
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110043#

metaM lac L e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
initial amount: NaN
constant: false
is: HMDB00190
name: (S)-lactate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false

metaM thymd c
initial amount: NaN
is: CHEBI:17748
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
name: Thymidine
is: HMDB00273
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00214
type: Species
is: SBO:0000247

metaR B3GNT32g
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000269

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_cd4369b5_fadc_47d7_876a_170bc138625f
is encoded by: hsa:2673
name: GFPT1
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: Q06210

metaM 5homeprazole c
constant: false
initial amount: NaN
type: Species
is: CHEBI:350546
is: HMDB00259
name: 5 hydroxy omeprazole
boundary condition: false
is: SBO:0000247
notes: FORMULA: C17H19N3O4S CHARGE: 0
initial concentration: 1.0
has only substance units: false

metaR FACOAL2251
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110043#
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_7dd4898d_25a2_4fd2_8e60_8f7539a3a855
name: EGFR
is: SBO:0000252
boundary condition: true
constant: false
is: P00533
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1956
initial concentration: NaN

metaM ocdca c
boundary condition: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00827
is: CHEBI:25629
type: Species
initial concentration: 1.0
name: stearate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b3620cce_209c_4d85_829f_dea1d9bb3529
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:5297
type: Species
is: B4DYG5
initial concentration: NaN
name: PI4KA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_4437d488_2cb6_4002_a3b3_bb72ee063bf4
name: COQ6
is: SBO:0000252
is encoded by: hsa:51004
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: B7Z3K8
initial concentration: NaN

metaR r2514
reversible: true
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
product: MODEL1310110043#
type: Reaction
fast: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9166d0fe_05df_46d0_8b33_a5522822f17a
boundary condition: true
type: Species
is: SBO:0000252
is: O95477
initial concentration: NaN
is encoded by: hsa:19
name: ABCA1
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_fe2e5b3b_564e_4bc9_bba3_a4c808a2a070
has only substance units: false
type: Species
is: P54709
boundary condition: true
is encoded by: hsa:483
initial amount: NaN
name: ATP1B3
is: SBO:0000252
constant: false
initial concentration: NaN

metaR RE0915E
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
type: Reaction
name: RE0915
is: SBO:0000176
product: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_471e74b9_bd5b_466a_a657_3bda8c807cf0
initial concentration: NaN
is: Q6IBC4
name: NDUFS6
type: Species
is: SBO:0000252
is encoded by: hsa:4726
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_a11c751d_8150_44ff_9bc6_a3ddc521e1e7
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: PPT1
initial amount: NaN
has only substance units: false
is: Q6FGQ4
is encoded by: hsa:5538
initial concentration: NaN

metaM so4 c
is: SBO:0000247
is: HMDB01448
type: Species
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16189
initial amount: NaN
name: sulfate

metaR RE1254C
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
reversible: true
name: RE1254
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is described by: ECO:0000000
type: Reaction

metaM btn c
is: CHEBI:3420
boundary condition: false
initial amount: NaN
is: HMDB00030
is: C00120
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false

metaR FACOAL203
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110043#

metaM ksii core4 pre8 g
is: SBO:0000247
constant: false
is: CHEBI:58053
type: Species
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 8
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00130
notes: FORMULA: C83H134N7O61SX CHARGE: -2
initial amount: NaN

metaM forglu c
constant: false
is: SBO:0000247
is: C00439
name: N-Formimidoyl-L-glutamate
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
boundary condition: false
is: CHEBI:18327
type: Species
is: HMDB00854
initial concentration: 1.0

metaR FACOAL2252
reversible: true
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110043#
fast: false
name: fatty-acid--CoA ligase
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110043#

metaR r0403
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110043#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_4737bec0_37b4_454a_b545_e692df53a146
is encoded by: hsa:5295
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: P27986
name: PIK3R1
is: SBO:0000252
initial concentration: NaN

metaR ILETA
name: isoleucine transaminase
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:

metaM 13 cis retn r
is: D00348
has only substance units: false
name: 13-cis-retinoate
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7847414
type: Species
is: SBO:0000247
is: HMDB06219
boundary condition: false
initial concentration: 1.0

metaR FACOAL204
reactant: MODEL1310110043#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110043#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110043#
name: fatty-acid--CoA ligase
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT

metaR O2Stm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#

metaR GHMT2r
is version of: http://identifiers.org/ec-code/2.1.2.1
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reversible: true
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110043#
type: Reaction
name: glycine hydroxymethyltransferase, reversible
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

metaM 2dpmhobq m
is: HMDB06484
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
constant: false
is: CHEBI:50771
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_54c965fa_02c6_42f2_9f9a_3c1834597c26
initial concentration: NaN
type: Species
name: ACAD8
is: Q6ZWP6
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:27034

metaR GLXtm
kinetic law: MODEL1310110043#
name: glyoxylate transport, mitochondrial
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#

metaM hista c
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: histamium
is: CHEBI:58432
is: HMDB00870
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

metaR r0591
kinetic law: MODEL1310110043#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#

metaM HC01118 r
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57310
boundary condition: false
initial amount: NaN
name: presqualene diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110043#_ab7712e6_cb63_4c66_a021_bdcad0f3f0a8
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GALE
boundary condition: true
is encoded by: hsa:2582
type: Species
is: SBO:0000252
is: Q38G75

http://identifiers.org/biomodels.db/MODEL1310110043#_8c49bb8b_ddb5_40a5_94cf_7879e9c677fb
is: SBO:0000252
constant: false
type: Species
is: Q9NYQ3
boundary condition: true
initial amount: NaN
is encoded by: hsa:51179
name: HAO2
initial concentration: NaN
has only substance units: false

metaM gal14acglcgalgluside hs g
is: SBO:0000247
name: Lactoneotetraosylceramide
constant: false
initial amount: NaN
type: Species
is: CHEBI:17103
has only substance units: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial concentration: 1.0
boundary condition: false

metaR FAOXC12DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM hdd2coa c
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: C05272
constant: false
is: CHEBI:61526
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945
has only substance units: false

metaR r1380
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_d5943e5b_9650_4e09_b273_6e75f377564c
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FOLR1
initial concentration: NaN
is encoded by: hsa:2348
type: Species
boundary condition: true
constant: false

metaR GALt4
reversible: true
name: galactose transport via sodium symport
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_fb75a508_1fb2_4ed7_a4a3_00b9a64cd097
is encoded by: hsa:115019
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: B3KXK1
name: SLC26A9

metaR FACOAL205
reversible: true
name: fatty-acid--CoA ligase
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR PHEACGLNt
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
name: PHEACGLN extracellular transport via diffusion

metaR r1966
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#

metaM 2ddecdicoa m
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: C05279
is: HMDB11123
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa

metaM pcrn m
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
type: Species
initial concentration: 1.0
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824

http://identifiers.org/biomodels.db/MODEL1310110043#_bcb71d85_deac_41ce_8e58_2df5b1fe33a8
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: Q86YW0
name: PLCZ1
is encoded by: hsa:89869
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_902de5de_93cf_402a_90e1_587a8cdf818e
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI653169
is: SBO:0000252
has only substance units: false
type: Species
name: _AI653169_1_c
constant: false
boundary condition: true

metaR r0974
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
reversible: true
fast: false
name: Active transport
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:

metaR RE1810M
reactant: MODEL1310110043#
is described by: ECO:0000000
name: RE1810
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
type: Reaction

metaR ADMDC
is described by: ECO:0000269
product: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.1.1.50
type: Reaction
name: adenosylmethionine decarboxylase
reversible: false
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
kinetic law: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
is: SBO:0000176

metaM tyr L c
type: Species
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17895
is: SBO:0000247
boundary condition: false
name: L-tyrosine
initial amount: NaN

metaM acgam c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
is: CHEBI:17411
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
name: N-acetyl-D-glucosamine

metaR r0590
fast: false
is described by: ECO:0000000
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110043#

metaR HYXNt
modifier: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
name: Hypoxanthine transport
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv

metaM pmtcrn c
is: SBO:0000247
is: HMDB00222
name: L-palmitoylcarnitine
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
boundary condition: false
initial amount: NaN

metaR DOLK U
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.7.1.108 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110043#
reactant: MODEL1310110043#
name: Dolichol kinase, human (uterus)
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000

metaR r1381
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reversible: true

metaM thyox L c
name: L-thyroxine
initial amount: NaN
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: CHEBI:18332
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00248

metaM glyc c
is: C00116
initial amount: NaN
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
boundary condition: false
constant: false
is: HMDB00131
initial concentration: 1.0
is: SBO:0000247
name: Glycerol
type: Species

metaR PI5P3K
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
modifier: MODEL1310110043#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-5-phosphate 3-kinase

metaR STRDNCCPT2
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
name: carnitine transferase
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110043#

metaR FACOAL206
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000269
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110043#_15c1f1f5_5a98_4ebd_8a02_4d42fc52f0eb
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6390
is: P21912
initial amount: NaN
name: SDHB
constant: false
has only substance units: false

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: suberylcoa

metaM ru5p D c
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58121
constant: false
name: D-ribulose 5-phosphate(2-)

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM acglcgalgbside hs g
has only substance units: false
initial amount: NaN
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
is: CHEBI:26174
initial concentration: 1.0
constant: false
boundary condition: false
name: GlcNAc-Gal globoside
is: SBO:0000247
type: Species

metaM taur c
has only substance units: false
is: C00245
is: CHEBI:3544
type: Species
is: HMDB00251
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247

metaM hista e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58432
boundary condition: false
name: histamium
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
has only substance units: false

metaM gdpddman c
constant: false
is: CHEBI:57964
is: HMDB01346
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
initial concentration: 1.0

metaR HS4ly
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: false
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#

metaM 3deccrn e
notes: FORMULA: C17H33NO5 CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB02250
type: Species
is: SBO:0000247
name: 3-hydroxydecanoylcarnitine
boundary condition: false
initial concentration: 1.0

metaM ksi pre32 g
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
has only substance units: false
boundary condition: false
is: CHEBI:28067

metaR 3AIBTm
is: SBO:0000176
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
name: L-3-aminoisobutyrate transaminase, mitochondrial
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000304
fast: false

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR EX c101crn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ef098294_6ae4_4ae0_b9bd_e857ccedfed5
is encoded by: hsa:412
initial concentration: NaN
name: STS
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P08842
type: Species
has only substance units: false

metaR r1968
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

metaR STRDNCCPT1
modifier: MODEL1310110043#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: carnitine O-palmitoyltransferase

metaM em2emgacpail prot hs r
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
boundary condition: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: CHEBI:16870
is: HMDB00086
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_0ab1b250_c6f9_4dc8_adf7_c257709eeb67
initial amount: NaN
initial concentration: NaN
is: P49914
constant: false
is: SBO:0000252
name: MTHFS
boundary condition: true
type: Species
is encoded by: hsa:10588
has only substance units: false

metaM malcoa c
is: C00083
initial amount: NaN
is: CHEBI:57384
initial concentration: 1.0
is: HMDB01175
type: Species
has only substance units: false
name: Malonyl-CoA
boundary condition: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
constant: false

metaR r0400
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR FAOXC180
is described by: ECO:0000269
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110043#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false

metaM tyr L e
name: L-tyrosine
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17895
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00158
type: Species

metaM lneldccoa m
is: HMDB01064
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
name: linoelaidyl coenzyme A
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
constant: false

metaM ac e
initial amount: NaN
is: CHEBI:30089
constant: false
type: Species
is: HMDB00042
boundary condition: false
is: SBO:0000247
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial concentration: 1.0

metaM thyox L e
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
has only substance units: false
name: L-thyroxine
is: HMDB00248
constant: false
is: CHEBI:18332
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR CYTK2n
is: SBO:0000176
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: cytidylate kinase (dCMP),nuclear
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110043#_0e603efc_d05c_478a_91c6_adde5a38e329
name: ADH4
is: P08319
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:127
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaR r2519
is described by: ECO:0000000
name: Utilized transport
type: Reaction
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_4444ad8c_2543_4c35_93ae_37cf895e3725
boundary condition: true
is encoded by: hsa:2352
has only substance units: false
is: Q05C14
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: FOLR3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_1eef737a_4805_4ab5_af21_224cf0faa42d
constant: false
has only substance units: false
name: GUCY2F
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2986
is: P51841

metaR PRO1xm
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
is described by: ECO:0000254
reversible: false
name: proline oxidase (NAD), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR GALASE14ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ed4d5534_aa17_483c_a45c_34f30b2439cf
name: FLAD1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:80308
boundary condition: true
initial amount: NaN

metaM thcholoylcoa x
is: SBO:0000247
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB12456
constant: false
initial amount: NaN
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27403

http://identifiers.org/biomodels.db/MODEL1310110043#_5c9a781a_eb4e_4136_a956_e7cf8fccc1b9
has only substance units: false
boundary condition: true
initial concentration: NaN
is: B7Z2M9
initial amount: NaN
constant: false
is encoded by: hsa:8525
name: DGKZ
type: Species
is: SBO:0000252

metaM acgam6p c
constant: false
is: CHEBI:57513
initial amount: NaN
name: N-acetyl-D-glucosamine 6-phosphate(2-)
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: HMDB01062

metaR DOLGPP Uer
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
product: MODEL1310110043#
is described by: ECO:0000000

metaM glyclt c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29805
constant: false
initial amount: NaN
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
name: glycolate
has only substance units: false
type: Species
is: HMDB00115

metaR r2403
type: Reaction
reversible: false
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM HC02216 c
name: prostaglandin-f2beta
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ce96fc0c_3e89_447e_982a_e496559d75a5
name: PCBD1
is encoded by: hsa:5092
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM urea m
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: C00086
name: Urea
boundary condition: false
is: CHEBI:16199
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00294
has only substance units: false

metaM man l
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
is: SBO:0000247
is: CHEBI:16024
boundary condition: false

metaM core3 g
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16250
has only substance units: false
name: Core 3
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ffeec0dd_799c_4e15_ad6c_e3c420f47172
is encoded by: hsa:6240
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: RRM1
boundary condition: true
is: P23921
has only substance units: false
is: SBO:0000252

metaR DM Lcystin
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM arab L e
is: HMDB00646
name: L-arabinose
is: SBO:0000247
boundary condition: false
is: CHEBI:30849
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
constant: false

metaM n2m2masn g
constant: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
is: C11530
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110043#_7976ee0e_ff98_43d8_abc1_2fe098ab3d3f
is encoded by: hsa:5209
is: Q16875
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: PFKFB3
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_5d46324b_8cea_4e09_9280_44f6fdc7464c
is: Q9UBK5
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: HCST
is encoded by: hsa:10870
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 5oxpro e
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00267
is: CHEBI:57606
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
name: 5-oxoprolinate

metaR RE1233C
fast: false
reversible: true
is: SBO:0000176
name: RE1233
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaR APAT2rm
reactant: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is described by: ECO:0000212
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
is: SBO:0000176

metaR r1630
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0409
product: MODEL1310110043#
reversible: true
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.10
modifier: MODEL1310110043#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000

metaR MI134P4P
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
fast: false
type: Reaction
name: inositol-1,3,4-trisphosphate 4-phosphatase
is described by: ECO:0000000

metaM ksi deg11 l
is: HMDB00143
is: CHEBI:12936
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 11
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM rbt e
is: CHEBI:15963
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
has only substance units: false
name: D-ribitol
is: HMDB00508

metaR GLCt4
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000185
name: glucose transport via sodium symport
fast: false
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_4ef024e0_5a33_49bb_98cb_789e296d8e69
has only substance units: false
is encoded by: hsa:1632
initial amount: NaN
is: SBO:0000252
name: ECI1
initial concentration: NaN
boundary condition: true
type: Species
is: P42126
constant: false

metaR r0594
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
fast: false
is: SBO:0000176
type: Reaction
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
kinetic law: MODEL1310110043#
is described by: ECO:0000000

metaR UMPK7n
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110043#
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a844d3d7_fd7e_47bb_97a0_30a2dd6aa259
boundary condition: true
is encoded by: hsa:219
constant: false
name: ALDH1B1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P30837
initial concentration: NaN
type: Species

metaM so4 m
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01448
is: CHEBI:16189
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaR GALACGLCGALGBSIDEte
fast: false
reversible: true
name: galacglcgalgbside hs transport
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
product: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_f21af632_e4d3_448e_a09c_6af84d9d79c3
name: ACOT6
is: Q3I5F7
has only substance units: false
constant: false
type: Species
is encoded by: hsa:641372
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_50f2dbc8_ca9c_4e7a_9d0d_4233603dfde7
is: Q9H008
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:64077
initial amount: NaN
name: LHPP

metaM HC02216 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: prostaglandin-f2beta
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:28922
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1

metaR MHISOR
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000269
is: SBO:0000176
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)

metaM btn m
name: biotinate
has only substance units: false
is: SBO:0000247
is: HMDB00030
is: CHEBI:57586
initial amount: NaN
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
boundary condition: false
type: Species
initial concentration: 1.0

metaM rbt c
is: HMDB00508
initial amount: NaN
type: Species
is: CHEBI:15963
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_d153edb0_6d0c_49c5_9a3b_967de183f152
is: SBO:0000252
is encoded by: hsa:8527
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DGKD
constant: false

metaR FAOXC14C12x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR RE0512M
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE0512

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaR FAOXC163C142x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaM arab L c
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
is: HMDB00646
initial concentration: 1.0
is: CHEBI:30849
boundary condition: false
constant: false
is: SBO:0000247
name: L-arabinose

metaM CE2422 m
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: HMDB11123
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: CHEBI:28387
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_9bf9d4c4_a186_4cc6_b310_9728a070f0e6
is encoded by: hsa:518
constant: false
is: P48201
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ATP5G3
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_45c40988_81d9_4c3c_b32e_f464692a2d27
has only substance units: false
name: ALDH3A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: P30838
is encoded by: hsa:218

metaM so4 l
name: sulfate
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
constant: false
is: HMDB01448

metaR UAGALDP
reactant: MODEL1310110043#
name: UDP-N-acetylgalactosamine diphosphorylase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176

metaR r0596
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
kinetic law: MODEL1310110043#
is: SBO:0000176
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
product: MODEL1310110043#

metaR r0973
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110043#
name: Facilitated diffusion
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_d18f8a1b_a801_4ef1_8b73_5fe8ce3ddd36
name: AGPAT1
is encoded by: hsa:10554
is: Q99943
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaR PAIL HStn
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
fast: false
name: phosphatidylinositol nuclear transport (diffusion)
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9e4e02ae_188d_4a88_a646_938f332249ec
is: Q96QE2
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC2A13
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:114134
constant: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_b0241048_4301_4d08_9643_1eca51a92376
constant: false
initial concentration: NaN
name: ACADVL
initial amount: NaN
boundary condition: true
is: P49748
has only substance units: false
is encoded by: hsa:37
is: SBO:0000252
type: Species

metaM glyc e
is: SBO:0000247
name: Glycerol
is: CHEBI:17754
initial concentration: 1.0
has only substance units: false
is: HMDB00131
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
boundary condition: false

metaM pmtcrn m
name: L-palmitoylcarnitine
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
type: Species
is: HMDB00222
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17490

metaR ACGAMPM
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: phosphoacetylglucosamine mutase
is version of: http://identifiers.org/ec-code/5.4.2.3
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reactant: MODEL1310110043#
product: MODEL1310110043#

metaM glyc m
is: SBO:0000247
initial amount: NaN
constant: false
name: Glycerol
is: CHEBI:17754
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00131
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110043#_ff6e7466_e8d3_4ce3_911a_e8dc29ef438e
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: ADSL
is encoded by: hsa:158
constant: false
initial amount: NaN
is: SBO:0000252

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
type: Reaction
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#

metaM crn x
boundary condition: false
has only substance units: false
name: L-Carnitine
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: C00318
is: CHEBI:16347
is: SBO:0000247

metaM gam c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
boundary condition: false
type: Species
is: CHEBI:17315
constant: false
initial amount: NaN
is: HMDB01514
is: C00329
name: D-Glucosamine

http://identifiers.org/biomodels.db/MODEL1310110043#_03e8da5c_133e_4ecd_a303_04009373a2cd
type: Species
name: A4GALT
initial amount: NaN
is encoded by: hsa:53947
initial concentration: NaN
is: Q9NPC4
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaM 25aics c
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: C04823
constant: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00797
is: CHEBI:58443
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaR C226COAtx
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: fatty acid intracellular transport
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_cda98480_0878_4244_8506_382fbc2618b4
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: E5KSL6
is encoded by: hsa:1716
name: DGUOK
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_1bc0defc_01a3_456b_a01f_80da06b7abc3
is encoded by: hsa:788
has only substance units: false
is: O43772
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: SLC25A20
initial amount: NaN
boundary condition: true

metaR MI1345PP
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110043#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
modifier: MODEL1310110043#
product: MODEL1310110043#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase

metaR CHOLPtg
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
is described by: ECO:0000000
is: SBO:0000185
name: choline phosphate intracellular transport
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
type: Reaction

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
product: MODEL1310110043#
is: SBO:0000176
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
reactant: MODEL1310110043#
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110043#

metaM ksi deg27 l
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
type: Species
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 27
is: HMDB00143
is: SBO:0000247
initial amount: NaN

metaM CE2418 m
is: SBO:0000247
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
is: HMDB11123
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110043#_2c24845c_0d89_43e9_b785_83217419f0cd
is: P19440
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2678
initial amount: NaN
name: GGT1
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM man g
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: D-mannose
is: CHEBI:16024
is: HMDB00169
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_60199df3_9c62_43bd_98e5_713cff554e25
constant: false
boundary condition: true
name: ITPKB
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P27987
initial amount: NaN
is encoded by: hsa:3707
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_f2c6d07b_d876_4157_9a35_1927c1b40ba0
is: Q06136
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: KDSR
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2531
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_1a70d2d9_1c37_40d4_9792_0e52cf63cabc
type: Species
constant: false
has only substance units: false
name: COX6B1
is: SBO:0000252
is encoded by: hsa:1340
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P14854

metaM lneldccoa c
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/9543677
is: HMDB06521
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
name: linoelaidyl coenzyme A
is: SBO:0000247

metaR EX 3octdece1crn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR NADH2 u10m
name: NADH dehydrogenase, mitochondrial
modifier: MODEL1310110043#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.5.3
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is version of: http://identifiers.org/ec-code/1.6.99.3
reversible: false
product: MODEL1310110043#

metaR CO2t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
name: CO2 transporter via diffusion

metaM pcrn c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00824
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
is: http://identifiers.org/pubchem.compound/107738
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_96ee93c8_a687_44f5_ba2e_4a2b0e7d9078
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10993
has only substance units: false
type: Species
boundary condition: true
constant: false
name: SDS
is: P20132
is: SBO:0000252

metaR SO4CLtex2
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: sulfate transport via chloride countertransport (2:1)
reversible: false
modifier: MODEL1310110043#
is described by: ECO:0000304
is: SBO:0000185
product: MODEL1310110043#

metaM dhlam m
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00985
boundary condition: false
is: CHEBI:17694
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_a384fe9b_8bbe_4b13_8bfa_fdd389a1ee56
is: SBO:0000252
is: A8K7W0
initial amount: NaN
constant: false
type: Species
name: VNN2
is encoded by: hsa:8875
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR DRPA
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: deoxyribose-phosphate aldolase
fast: false
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR r0408
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110043#
type: Reaction
fast: false
reactant: MODEL1310110043#
reversible: true
is: SBO:0000176
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
product: MODEL1310110043#
modifier: MODEL1310110043#

metaM pacald c
is: CHEBI:16424
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: HMDB06236
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: phenylacetaldehyde
initial concentration: 1.0

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: beta-galactosidase, lysosomal
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_fc32c8e6_431e_4c27_ae48_b9ba234ace43
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:84720
initial concentration: NaN
constant: false
name: PIGO
is: Q8TEQ8

http://identifiers.org/biomodels.db/MODEL1310110043#_1eb0abbf_7f2e_4c7e_b5dc_8ab59abee2da
is: Q99714
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3028
is: SBO:0000252
has only substance units: false
constant: false
name: HSD17B10
type: Species

metaR TYMSULT
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110043#
reversible: false
name: Tyramine Sulfotransferase
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is described by: ECO:0000269
modifier: MODEL1310110043#

metaR ACACt2m
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110043#
name: Acetoacetate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
fast: false

metaR S6T9g
reversible: false
fast: false
is described by: ECO:0000000
modifier: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#

metaM gam e
is: CHEBI:17315
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: HMDB01514
is: SBO:0000247
initial concentration: 1.0
name: D-Glucosamine
is: C00329
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ec80a448_d3d7_43b4_bfec_0a3d4addccac
initial concentration: NaN
name: ACSL4
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2182
boundary condition: true
is: O60488
type: Species
has only substance units: false

metaM 2ddecdicoa x
initial amount: NaN
is: HMDB11123
constant: false
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa
is: C05279
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR NACHEX22ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110043#
reversible: false
product: MODEL1310110043#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110043#

metaM hx2coa m
type: Species
initial concentration: 1.0
is: HMDB06870
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
initial amount: NaN
constant: false
is: C05998
name: trans-Hex-2-enoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247

metaR 2HBt2
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
fast: false
name: 2-hydroxybutyrate cotransport with proton
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110043#
is: SBO:0000185
reversible: true

metaR HEXCOAACBP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5b5a474a_ffcc_4693_bfec_339c65c91b83
initial amount: NaN
is encoded by: hsa:728637
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _728637_1_c
type: Species
initial concentration: NaN
constant: false

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110043#
is described by: ECO:0000000

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR EX decdicrn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaR r1961
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#

metaM 5oxpro c
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: HMDB00267
name: 5-oxoprolinate
type: Species
is: CHEBI:57606
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM ac m
initial amount: NaN
type: Species
name: acetate
is: HMDB00042
has only substance units: false
is: CHEBI:30089
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM man e
is: SBO:0000247
is: HMDB00169
is: CHEBI:16024
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-Mannose
type: Species
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
is: C00159

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM leuktrB4 c
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
type: Species
name: leukotriene B4(1-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57461
is: SBO:0000247
has only substance units: false
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110043#_6bbf9949_5b8c_4fc4_9f93_6cdec866ea61
initial amount: NaN
is: Q7LG56
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:50484
name: RRM2B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_3389823f_e5c8_49f7_9c41_f0ed238c8bfe
is encoded by: hsa:AI971023
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: _AI971023_1_c
type: Species
initial concentration: NaN

metaR FAOXC11C9m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR GALACGLCGALGBSIDEtg
type: Reaction
name: galacglcgalgbside hs intracellular transport
kinetic law: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaR VLCS2p
is described by: ECO:0000304
reactant: MODEL1310110043#
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM hco3 c
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
initial amount: NaN
is: HMDB00595
constant: false
is: CHEBI:17544
boundary condition: false
name: Bicarbonate
has only substance units: false

metaM paf hs c
initial concentration: 1.0
is: CHEBI:36707
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
constant: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ad9984d2_6460_41b6_9397_a44792aa120d
name: AKR1C4
boundary condition: true
is encoded by: hsa:1109
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: P17516
has only substance units: false
initial amount: NaN

metaM retn e
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:35291
name: all-trans-retinoate
is: HMDB01852

http://identifiers.org/biomodels.db/MODEL1310110043#_5a17d938_8fb1_4fd5_a9de_a5effe98ac22
is encoded by: hsa:122622
boundary condition: true
is: Q8N142
is: SBO:0000252
initial concentration: NaN
type: Species
name: ADSSL1
has only substance units: false
initial amount: NaN
constant: false

metaR MM6bg
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
reactant: MODEL1310110043#
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

metaR LSTO1r
name: Lathosterol oxidase
reversible: false
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.21.6

metaR DITPtn
reactant: MODEL1310110043#
name: dITP nuclear transport
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR r1648
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM 3octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
constant: false
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaR r0743
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reactant: MODEL1310110043#
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#

metaR CYSO
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.20
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
reactant: MODEL1310110043#
reversible: false
type: Reaction
name: cysteine oxidase
kinetic law: MODEL1310110043#

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: CHEBI:16953
is: HMDB00812
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C37H54NO41S3 CHARGE: -5
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_5a011c08_19b6_4736_a422_22d2fcfc4cb7
is encoded by: hsa:10690
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: Q9Y231
boundary condition: true
constant: false
initial concentration: NaN
name: FUT9

metaR APOC LYS BTNPm
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110043#
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
type: Reaction
name: proteolysis of apoC-Lys-btn, mitochondrial

metaM ksi pre21 g
constant: false
name: keratan sulfate I biosynthesis, precursor 21
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
type: Species
has only substance units: false
is: HMDB00175
boundary condition: false
is: C00130
is: CHEBI:58053
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_b895e6f8_b6c4_4a79_9a0f_de97bd29e3a4
boundary condition: true
is encoded by: hsa:51292
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: GMPR2
is: Q86T14
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_d3a7d11a_04f5_48df_862b_c4b02d79d384
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:5152
is: SBO:0000252
constant: false
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110043#_a6755043_5e43_4d94_b740_596a5d07397b
is: P43155
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1384
constant: false
initial amount: NaN
name: CRAT
is: SBO:0000252

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR MTHFC
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110043#
modifier: MODEL1310110043#
name: methenyltetrahydrofolate cyclohydrolase
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/3.5.4.9

metaM c226coa m
constant: false
is: SBO:0000247
name: cervonyl coenzyme A
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C16169
is: http://identifiers.org/pubchem.compound/47205479

metaM dhor S c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: HMDB03349
has only substance units: false
type: Species
name: (S)-dihydroorotate
constant: false
is: CHEBI:30864

metaR r1647
type: Reaction
product: MODEL1310110043#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_e9bd4153_4f0c_47e6_8f08_94534078c3ba
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29968
boundary condition: true
is: Q9Y617
type: Species
name: PSAT1
constant: false

metaM cmpacna g
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
is: CHEBI:57812
initial amount: NaN
is: HMDB01176

http://identifiers.org/biomodels.db/MODEL1310110043#_b0159433_9d49_4e1e_9a97_d4ed1b90d433
name: NDUFB6
initial amount: NaN
is: Q5VYT2
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4712
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_b22a0a69_4ccf_42b2_9073_a7ac6dee98f4
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PIGC
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5279

http://identifiers.org/biomodels.db/MODEL1310110043#_67164407_888b_4171_a588_4a86a2c1bb46
constant: false
is encoded by: hsa:386757
type: Species
has only substance units: false
initial concentration: NaN
name: SLC6A10P
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR HOXG
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.99.3
kinetic law: MODEL1310110043#
fast: false
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
name: Heme oxygenase 1
reversible: false
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
is described by: ECO:0000134
product: MODEL1310110043#

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28325

metaM hco3 e
is: CHEBI:17544
initial concentration: 1.0
is: C00288
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: Bicarbonate
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_3745e57f_27ac_49bf_a39c_69a0b8450ded
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2650
initial concentration: NaN
name: GCNT1
initial amount: NaN
constant: false
boundary condition: true
is: Q02742
type: Species

metaM paf hs e
has only substance units: false
is: CHEBI:36707
initial concentration: 1.0
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_bcb074ba_e392_4194_b334_e5fe55df969c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:513
constant: false
initial concentration: NaN
name: ATP5D

metaM malcoa r
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)
initial amount: NaN
is: CHEBI:57384
initial concentration: 1.0
is: HMDB01175
has only substance units: false

metaR VLCS2r
reversible: false
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110043#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110043#

metaM arg L c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
constant: false
has only substance units: false
is: HMDB00517
is: CHEBI:32682
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_adc914ff_7a04_42e1_904a_0a3ea9afbe94
name: LDHAL6B
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:92483
boundary condition: true
is: Q9BYZ2
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR r0741
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
modifier: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
reversible: true
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15

http://identifiers.org/biomodels.db/MODEL1310110043#_459f26c1_5ba1_49ff_8379_c7fbc49b1f19
constant: false
is encoded by: hsa:1811
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC26A3
is: P40879
is: SBO:0000252

metaR ACOAO7p
reversible: false
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
modifier: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d8c52379_1441_4132_af9f_bfecb39878c7
boundary condition: true
initial amount: NaN
has only substance units: false
name: TXNRD2
initial concentration: NaN
constant: false
is encoded by: hsa:10587
is: SBO:0000252
type: Species

metaM hs deg5 l
is: HMDB00158
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
has only substance units: false
is: SBO:0000247
is: CHEBI:17895
boundary condition: false
type: Species
initial concentration: 1.0
name: heparan sulfate, degradation product 5
initial amount: NaN
constant: false

metaR GLCNACASE4ly
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110043#

metaR PPCOAOm
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reactant: MODEL1310110043#
modifier: MODEL1310110043#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
fast: false
is described by: ECO:0000269
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_f0af3159_a4d0_465b_a824_3bf0f6186b59
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:52
has only substance units: false
boundary condition: true
is: B5MCC7
initial concentration: NaN
name: ACP1
constant: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM nadh c
boundary condition: false
is: SBO:0000247
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
has only substance units: false
is: HMDB01487
initial amount: NaN
type: Species
is: C00004
is: http://identifiers.org/pubchem.compound/3306
constant: false

metaR NODe
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110043#
name: NODe
reversible: true
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110043#

metaM ksi pre25 g
has only substance units: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
name: keratan sulfate I biosynthesis, precursor 25
is: C00130
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
initial amount: NaN

metaR DOLGLCP Uter
reversible: false
reactant: MODEL1310110043#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000

metaR PEROXx
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
name: peroxisomal lumped long chain fatty acid oxidation
modifier: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: false

metaR r1649
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM occoa c
constant: false
is: HMDB01070
type: Species
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_c29808d8_3728_4fdb_8268_af918e5b425e
name: AMACR
has only substance units: false
boundary condition: true
constant: false
is: Q3KT79
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:23600
type: Species
initial amount: NaN

metaM cytd e
initial concentration: 1.0
is: HMDB00089
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
has only substance units: false
name: Cytidine
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17562
initial amount: NaN
is: C00475

metaR H2Otn
reversible: true
type: Reaction
name: H2O transport, nuclear
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000

metaR PVD3
type: Reaction
product: MODEL1310110043#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
name: Previtamin D3 formation
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

http://identifiers.org/biomodels.db/MODEL1310110043#_2c914f93_bd57_4e40_b2b3_ac7366cd0939
is: Q08M29
initial amount: NaN
name: GCNT2
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2651
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_1633b285_0e01_4b33_a3ae_2c6bc643a9e5
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:509
constant: false
name: ATP5C1
is: Q6I9V2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_8e1d5579_d75d_4189_a51f_8f82a53ddb27
has only substance units: false
is: Q99424
is: SBO:0000252
name: ACOX2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8309
constant: false

metaM dd2coa x
is: HMDB03712
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
constant: false

metaR CITtam
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
name: citrate transport, mitochondrial
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
product: MODEL1310110043#

metaR r1644
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r0156
reactant: MODEL1310110043#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_b72d4f99_fa96_47d8_83b6_af113ff86180
is: SBO:0000252
is: Q6UWQ5
name: LYZL1
is encoded by: hsa:84569
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR HEXDCRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR ACOAD9m
reactant: MODEL1310110043#
product: MODEL1310110043#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
modifier: MODEL1310110043#

metaR TKT2
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
name: transketolase

metaR H2O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
is: SBO:0000185
fast: false
name: hydrogen peroxide transport via diffusion
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_f3f72d0c_e343_4a07_a270_6f8d18dc76e3
type: Species
is encoded by: hsa:84649
initial amount: NaN
name: DGAT2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q96PD7
constant: false

metaM 34dhphe e
is: CHEBI:15765
is: HMDB00181
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
initial concentration: 1.0
initial amount: NaN
name: L-dopa
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9f8ce274_95e6_45f3_9a5b_d16fc5a9527e
is: B4DER4
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: PIK3CB
is encoded by: hsa:5291

metaR FUCASEe
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
name: alpha-fucosidase, extracellular
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: false

metaR H2Otm
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
name: H2O transport, mitochondrial
fast: false
reversible: true
type: Reaction
product: MODEL1310110043#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_f0e38bbc_048b_4a04_b55c_325061c616b4
name: SPTLC1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: O15269
has only substance units: false
is encoded by: hsa:10558
boundary condition: true
initial amount: NaN

metaR GALNTg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is: SBO:0000176
name: GalNAc transferase, Golgi apparatus
type: Reaction
fast: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.41
reversible: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR r0157
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110043#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/6.3.4.2

metaR r1643
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_33f71439_734d_483c_bd5b_aba3b99d6f05
is: Q86U05
is encoded by: hsa:23428
constant: false
type: Species
boundary condition: true
name: SLC7A8
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_e2abe6a4_209e_4c40_9df5_e19a3169984f
initial amount: NaN
has only substance units: false
is encoded by: hsa:53630
type: Species
is: SBO:0000252
boundary condition: true
is: Q9HAY6
constant: false
name: BCMO1
initial concentration: NaN

metaR RE1447N
kinetic law: MODEL1310110043#
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110043#
reversible: true

metaM cytd c
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
name: Cytidine
boundary condition: false
is: HMDB00089
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17562
initial amount: NaN
is: C00475

metaR FRDPtr
name: lipid, flip-flop intracellular transport
reversible: true
product: MODEL1310110043#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110043#

metaR r1252
reactant: MODEL1310110043#
fast: false
name: EC:6.2.1.3
product: MODEL1310110043#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM ksi deg40 l
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 40
constant: false
type: Species
has only substance units: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: HMDB00143
is: CHEBI:12936
initial amount: NaN

metaM 3mgcoa m
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57346
is: SBO:0000247
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
name: trans-3-methylglutaconyl-CoA(5-)
is: HMDB01057
boundary condition: false
has only substance units: false
type: Species

metaR GALK
product: MODEL1310110043#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.6
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.157
name: galactokinase
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is: SBO:0000176

metaR H2Otp
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, peroxisomal
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM 3php c
constant: false
boundary condition: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: HMDB01024
is: CHEBI:18110
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: 3-phosphonatooxypyruvate(3-)

http://identifiers.org/biomodels.db/MODEL1310110043#_94b6b65e_0a7f_4cee_b885_27ffc18ce735
initial amount: NaN
type: Species
name: _22305_2_c
constant: false
is encoded by: hsa:22305
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_1fc97524_2689_4270_8f9a_fd4b05c47194
type: Species
name: PDE5A
is: G5E9C5
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:8654

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5d1c53bb_e021_45a2_962b_8a68e63e6a8b
is: SBO:0000252
name: AKR1A1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:10327
type: Species
initial concentration: NaN

metaR GCHOLAte
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
reversible: true
name: bile acid intracellular transport

metaR S6T12g
modifier: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
fast: false

metaR C18OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR PRAGSr
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.2.2
name: phosphoribosylglycinamide synthase
modifier: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_0fac9b32_15c8_4c98_834b_78ac56cafbca
is: Q96A70
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ADC
constant: false
is encoded by: hsa:113451
has only substance units: false
initial amount: NaN

metaR r1646
reversible: true
product: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#

metaR FACOAL1831
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110043#
name: fatty-acid--CoA ligase
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110043#

metaR r0267
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.1.9
is described by: ECO:0000000
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
fast: false

metaM 34dhphe c
constant: false
type: Species
is: CHEBI:15765
is: HMDB00181
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
name: L-dopa
initial amount: NaN

metaR DOLPGT2 Uer
reactant: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.265
modifier: MODEL1310110043#
type: Reaction
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_de115ec3_aa86_43d9_a409_4fe16ae288b4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:84076
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9H0I9
name: TKTL2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_86c5ee97_8840_49d7_aae6_d5da332d92cf
constant: false
name: PPCS
is: Q9HAB8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79717
initial amount: NaN
has only substance units: false
type: Species

metaR RE1447M
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
name: RE1447
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_80f29139_ba36_4c08_b00a_b97fd891247a
constant: false
name: ATP5J
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:522
has only substance units: false
initial concentration: NaN

metaR ACCOALm
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
fast: false
kinetic law: MODEL1310110043#
name: acetate-CoA ligase (AMP-forming)
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
reactant: MODEL1310110043#

metaM h2o2 c
initial amount: NaN
boundary condition: false
is: C00027
has only substance units: false
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
is: CHEBI:16240
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM sph1p e
constant: false
type: Species
initial concentration: 1.0
is: HMDB01383
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120

metaR XYLt
fast: false
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110043#
reactant: MODEL1310110043#
name: D-xylose reversible transport
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

metaM pre prot r
is: CHEBI:16038
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: XY CHARGE: 0
boundary condition: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_53d94a66_23e3_4caf_a591_282740aa9626
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4121
constant: false
is: P33908
name: MAN1A1
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r1645
product: MODEL1310110043#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_148682ab_ec35_4ca0_bf3d_2cd2afc94c2d
has only substance units: false
name: ADH6
is encoded by: hsa:130
initial concentration: NaN
is: P28332
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_504f0393_32cb_4e6e_9064_4dc8078a1664
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: _AL050025_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL050025
is: SBO:0000252

metaR r0268
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR FACOAL1832
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
name: fatty-acid--CoA ligase
modifier: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
product: MODEL1310110043#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_b2ef4ed3_2245_430e_84c4_8f9954ffd0e5
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:23305
boundary condition: true
name: ACSL6
type: Species
has only substance units: false
is: B2RB13
is: SBO:0000252

metaR HPDCAt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110043#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_3468e4b5_4d06_4539_8432_0bbd3112d645
has part: P18859
is: SBO:0000297
is encoded by: hsa:518
initial amount: NaN
is encoded by: hsa:10476
boundary condition: true
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P24539
constant: false
initial concentration: NaN
has only substance units: false
has part: O75947
is encoded by: hsa:515
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_ce3ad978_f899_47b5_bbaa_f62fec817f07
is encoded by: hsa:226
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDOA
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM thr L e
name: L-threonine
is: HMDB00167
is: CHEBI:16857
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR STRDNCt
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110043#
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false

metaM 2docohexecoa m
constant: false
name: 2,7,10,13,16,19-docosahexenoylcoa
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7677274b_5cb1_41b1_8f6e_d2d9824fa418
is encoded by: hsa:1809
initial concentration: NaN
constant: false
initial amount: NaN
is: Q8IXW6
has only substance units: false
boundary condition: true
type: Species
name: DPYSL3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_b22f85fd_75c2_4314_9f3e_c0e478f9ed3d
is: SBO:0000252
is encoded by: hsa:2592
is: B2RAT6
name: GALT
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR B3GNT314g
kinetic law: MODEL1310110043#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reversible: false
fast: false

metaM pac c
has only substance units: false
is: HMDB00209
name: phenylacetate
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial concentration: 1.0

metaR TRIODTHYt2
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: T3 transport via facilitated diffusion
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185

metaR FAOXC61m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR GGH 7THFe
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
fast: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_4fca202e_1f20_4253_a248_7ef61ea2e07f
type: Species
has only substance units: false
is: Q16775
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: HAGH
boundary condition: true
is encoded by: hsa:3029

metaM g3p c
name: Glyceraldehyde 3-phosphate
has only substance units: false
is: C00661
boundary condition: false
is: HMDB01112
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: CHEBI:58027
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_ccec8d92_c19a_4b03_95d7_01dc3698f8df
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:83530
is: SBO:0000252
initial amount: NaN
constant: false
name: _83530_1_c
has only substance units: false

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR GASNASE3ly
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
reversible: false
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000000
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_ea397dc8_42e5_4c5d_a7cf_934e1cd1c810
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: _AI926493_1_m
type: Species
is encoded by: hsa:AI926493
initial concentration: NaN
boundary condition: true

metaR RE3556C
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110043#
reversible: true
name: RE3556
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
fast: false

metaM dcsptn1crn c
type: Species
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06321
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_423ed210_5335_4755_b9a6_5161ba5f559e
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6522
boundary condition: true
name: SLC4A2
is: F8W682
is: SBO:0000252
initial amount: NaN
type: Species

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false

metaM sph1p c
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57939
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
has only substance units: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383

metaR FADtru
reversible: false
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
product: MODEL1310110043#
name: FAD transporter, endoplasmic reticulum
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000000

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_d51b4c13_df9a_46ed_8fa3_f7e018cec080
initial amount: NaN
is: Q9P019
constant: false
name: PHPT1
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:29085

metaM itaccoa m
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: itaconyl-CoA(5-)
constant: false
initial concentration: 1.0
type: Species
is: HMDB03377
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381

metaM h2o2 e
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: CHEBI:16240
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: hydrogen peroxide

metaM dem2emgacpail prot hs r
has only substance units: false
is: HMDB02925
initial concentration: 1.0
constant: false
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
type: Species
boundary condition: false
is: CHEBI:53486
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0

metaR AMPDA
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.6
name: Adenosine monophosphate deaminase
modifier: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction

metaM xu1p D c
name: D-Xylulose 1-phosphate
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
initial concentration: 1.0
is: HMDB06534
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_ae0d2e52_3448_42f5_83b6_62d637c4d442
name: DPM1
boundary condition: true
has only substance units: false
initial amount: NaN
is: O60762
constant: false
is encoded by: hsa:8813
type: Species
is: SBO:0000252
initial concentration: NaN

metaM thr L c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16857
name: L-threonine
constant: false

metaM pcrn x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
constant: false
initial concentration: 1.0
name: propionyl-carnitine
has only substance units: false
boundary condition: false
is: HMDB00824

http://identifiers.org/biomodels.db/MODEL1310110043#_74dae122_1ee2_42f7_a108_5fd6dd9fdbf4
name: TXNRD2
is: Q9NNW7
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:10587
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b77665be_6aa6_485c_bd50_7cb2bb3caa58
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q99884
type: Species
is encoded by: hsa:6534
is: SBO:0000252
name: SLC6A7

metaM 2docopencoa x
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
constant: false

metaR S6TASE23ly
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true

metaR TAGt
name: triacylglycerol transport
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f80fb620_1003_4aa9_b2a3_344c7ae411de
is: SBO:0000252
is encoded by: hsa:10841
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: FTCD

http://identifiers.org/biomodels.db/MODEL1310110043#_0ffe12ee_c548_4c63_aef6_708dc8ef6336
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:5144
boundary condition: true
constant: false
is: SBO:0000252
is: Q08499
initial concentration: NaN
name: PDE4D

http://identifiers.org/biomodels.db/MODEL1310110043#_82a38a60_475b_4307_9766_03d5d1f7d9c2
name: SLC2A8
is: SBO:0000252
is: Q9NY64
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:29988
has only substance units: false
initial concentration: NaN
type: Species

metaR TKT1
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false
name: transketolase
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_fa1fcd00_7958_4741_8bbc_14ff96d78882
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ALDH1A3
constant: false
is: P47895
is encoded by: hsa:220
type: Species
boundary condition: true

metaM decdicrn e
notes: FORMULA: C17H29NO4 CHARGE: 0
is: HMDB13325
type: Species
name: decadienoyl carnitine
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR GALASE7ly
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110043#

metaR AMPTASECG
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.1 Confidence Level: 1 AUTHORS: PMID:12675513 NOTES:SAB. activity measured in cytosol rat liver; IT IS leucine aminopeptidase (EC3.4.11.1) NOT alanyl aminopeptidase EC3.4.11.2 which shows > 80% of the activity; sequence homology rat-human not yet verified; annotation 'extracellular' under B column ERROR
fast: false
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.11.2
reactant: MODEL1310110043#
reversible: false
is described by: ECO:0000212
name: alanyl aminopeptidase (cys-gly)
product: MODEL1310110043#

metaR RE2974C
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.149
modifier: MODEL1310110043#
reversible: true
fast: false
is: SBO:0000176
name: RE2974
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#

metaM estrone c
boundary condition: false
is: CHEBI:17263
has only substance units: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
initial concentration: 1.0
name: estrone
initial amount: NaN
is: HMDB00145

metaM ksi deg29 l
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:12936
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 29
boundary condition: false
type: Species

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM eicostetcoa c
name: eicosatetranoyl coenzyme A
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: C16164
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_ac101bfd_1017_4960_a083_982f010ab73c
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI373818_1_m
is encoded by: hsa:AI373818
constant: false
initial concentration: NaN

metaM c226coa x
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: C16169
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A
boundary condition: false

metaM orn m
initial concentration: 1.0
boundary condition: false
is: C01602
is: CHEBI:46912
type: Species
initial amount: NaN
is: HMDB00214
has only substance units: false
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
name: Ornithine

metaM cmusa c
is: C04409
notes: FORMULA: C7H6NO5 CHARGE: -1 INCHI: InChI=1S/C7H7NO5/c8-5(7(12)13)4(6(10)11)2-1-3-9/h1-3H,8H2,(H,10,11)(H,12,13)/p-2/b2-1-,5-4- HEPATONET_1.0_ABBREVIATION: HC01288 EHMN_ABBREVIATION: C04409
name: cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:994
is: SBO:0000247

metaR r0747
is described by: ECO:0000000
reversible: true
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
type: Reaction
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_a75890b3_ce90_41d7_9c01_7da7a99c8a84
type: Species
name: TH
constant: false
is encoded by: hsa:7054
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR NACHEX14ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110043#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110043#

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_53bdcd72_fcd7_447b_866a_5a84396b9f34
constant: false
name: ACAA1:HSD17B4:ACOX1
is encoded by: hsa:3295
type: Species
initial concentration: NaN
has part: E9PB82
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000297

metaM tyr L m
boundary condition: false
initial concentration: 1.0
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
name: L-tyrosine
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17895
constant: false

metaR FAOXC14C12m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR FE3R2e
type: Reaction
modifier: MODEL1310110043#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Fe(III) reduction (ascorbate)
fast: false
reactant: MODEL1310110043#
is: SBO:0000176

metaM decdicrn c
is: HMDB13325
is: SBO:0000247
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
name: decadienoyl carnitine
initial amount: NaN
has only substance units: false
type: Species

metaR RE0958E
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM 4h2oglt m
initial concentration: 1.0
constant: false
type: Species
is: HMDB02070
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
initial amount: NaN
name: 4-hydroxy-2-oxoglutarate(2-)
boundary condition: false
is: CHEBI:17742

metaR FAOXC226205m
modifier: MODEL1310110043#
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR FAOXC8C6m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaM fuc12gal14acglcgalgluside hs g
type: Species
is: HMDB00304
name: Type IIH glycolipid
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:57847

metaM cmpacna c
is: HMDB01176
is: CHEBI:57812
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR RE0936E
type: Reaction
modifier: MODEL1310110043#
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11815627 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.17.23
name: RE0936

metaM arg L e
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: L-argininium(1+)
is: CHEBI:32682
constant: false
has only substance units: false

metaR r1538
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110043#
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is described by: ECO:0000000

metaR RTOTAL2FATPc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaM ppcoa c
is: CHEBI:57392
is: C00100
name: Propanoyl-CoA
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
is: HMDB01275
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_3cfea541_ce32_4ff2_8c31_8708490c7c84
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:2348
type: Species
name: FOLR1
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR FAOXC5C5OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3ef362be_e5c9_42d1_bdc3_9b6ae2c2452d
initial concentration: NaN
is: SBO:0000297
name: ATP1A1:ATP1B3
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:483
constant: false
is encoded by: hsa:476
type: Species
has part: P54709
has part: B7Z3U6

metaR RE1521M
reversible: true
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
name: RE1521
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR MEVK1c
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is described by: ECO:0000134
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
fast: false
reactant: MODEL1310110043#
name: mevalonate kinase (atp) cytosol
is version of: http://identifiers.org/ec-code/2.7.1.36

metaR TRPt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
name: L-tryptophan transport
product: MODEL1310110043#
reversible: true
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

metaM h2o2 m
initial amount: NaN
is: CHEBI:16240
is: C00027
name: Hydrogen peroxide
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB03125
has only substance units: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false

metaR GALT
reversible: true
type: Reaction
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110043#
is: SBO:0000176
name: galactose-1-phosphate uridylyltransferase

metaR BTNPLm
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
kinetic law: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000

metaM retn c
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
has only substance units: false
name: all-trans-retinoate
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:35291

http://identifiers.org/biomodels.db/MODEL1310110043#_43a06cdb_2059_4196_bdbe_182ac294bfc5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: LDHB
is encoded by: hsa:3945
is: P07195
boundary condition: true

metaM decdicoa c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: decadienoylcoa
boundary condition: false
type: Species
constant: false

metaR OCCOAtm
fast: false
name: Octanoyl-CoA transport, diffusion
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110043#_a7b4526b_b1fe_4447_ba2a_fb401b81f4fe
type: Species
name: CA14
is: A8K3J4
is encoded by: hsa:23632
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_b97ffe4d_9501_49b2_96b2_75824f8b7acb
has only substance units: false
initial concentration: NaN
constant: false
name: ALDH3B2
is: P48448
initial amount: NaN
type: Species
is encoded by: hsa:222
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_b2a71695_d2c3_4a9d_945c_79fc81f0fe62
initial amount: NaN
is: Q8TDB8
has only substance units: false
constant: false
type: Species
name: SLC2A14
is encoded by: hsa:144195
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM retfa e
name: fatty acid retinol
type: Species
constant: false
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15963
is: HMDB00508
has only substance units: false

metaR NDP8
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.9
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
type: Reaction
is described by: ECO:0000269

metaR GALU
reversible: true
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000134
name: UTP-glucose-1-phosphate uridylyltransferase
modifier: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.7.9

metaR r0744
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
type: Reaction
fast: false

metaR TETHEX3t
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110043#
name: fatty acid transport via diffusion
is: SBO:0000185

metaM cs d deg2 l
is: HMDB00812
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:16953
is: SBO:0000247
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d8cbb75c_746c_4e64_b892_f7b122a77061
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:51292
name: GMPR2
initial concentration: NaN

metaM hLkynr c
is: CHEBI:17380
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB11631
constant: false
name: 3-hydroxy-L-kynurenine
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_52b9deb5_b20e_47f5_82ab_1d10959d6121
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55811
is: F5GWS5
initial amount: NaN
boundary condition: true
name: ADCY10

metaM g1p c
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
boundary condition: false
type: Species
is: C00103
is: CHEBI:58601
constant: false
has only substance units: false
initial concentration: 1.0
name: D-Glucose 1-phosphate
is: SBO:0000247
is: HMDB01586

http://identifiers.org/biomodels.db/MODEL1310110043#_a51bafc3_966b_4e31_bd91_dfac9452c2e8
is: Q13825
is encoded by: hsa:549
is: SBO:0000252
type: Species
name: AUH
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM dec24dicoa x
name: 2,4-decadienoylcoa
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_4f82b4ec_a183_438a_8e57_f8f287f2aa6a
initial amount: NaN
boundary condition: true
is encoded by: hsa:AU149534
is: SBO:0000252
name: _AU149534_1_e
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaM arachd e
is: HMDB01043
boundary condition: false
type: Species
name: arachidonate
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaR 4ABUTtm
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
name: 4-aminobutanoate mitochondrial transport via diffusion
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5df93056_9518_4fed_a3d6_edd8c7df6353
has only substance units: false
is: SBO:0000252
is: Q13733
boundary condition: true
name: ATP1A4
initial amount: NaN
is encoded by: hsa:480
constant: false
type: Species
initial concentration: NaN

metaR ADK1m
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110043#
name: adenylate kinase, mitochondrial
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM retfa c
boundary condition: false
is: HMDB00305
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:50211
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid retinol

http://identifiers.org/biomodels.db/MODEL1310110043#_43957756_7640_49e7_bb3a_dd8e20cf39a8
initial concentration: NaN
type: Species
name: ATP5F1
is: Q08ET0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:515
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_dc7203ec_482e_4297_8873_8fef9b0c3fb5
type: Species
constant: false
is: Q4W5N8
boundary condition: true
is encoded by: hsa:51166
name: AADAT
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_689b6795_ec5a_4bd1_adec_0e0da9e72d29
type: Species
has only substance units: false
constant: false
name: _FLJ44968_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:FLJ44968
is: SBO:0000252
initial concentration: NaN

metaR r0698
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
type: Reaction
reversible: true
reactant: MODEL1310110043#
is: SBO:0000176
fast: false
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110043#

metaM ppcoa x
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
constant: false
is: CHEBI:57392
initial concentration: 1.0
initial amount: NaN
is: HMDB01275
is: C00100

http://identifiers.org/biomodels.db/MODEL1310110043#_ac36e3d7_ceac_4198_8adc_54aa811d8909
is: SBO:0000252
is: B7Z5T8
is encoded by: hsa:1375
name: CPT1B
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 2docopencoa m
type: Species
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_94b8d953_5cbd_4d35_a839_2e66346eb791
constant: false
initial concentration: NaN
name: PIGF
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5281
type: Species
is: Q07326
boundary condition: true
has only substance units: false

metaM 2dp6mobq me m
type: Species
is: SBO:0000247
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
boundary condition: false
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
initial amount: NaN
is: CHEBI:50772
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_9d2cdf9b_76ba_470c_880f_d54ece2d326a
has only substance units: false
type: Species
constant: false
boundary condition: true
is: H0YMZ7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5151
is: SBO:0000252
name: PDE8A

metaM 2octpencoa m
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 2,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_70e238fb_93e8_47a3_8682_8775780db0f8
is: SBO:0000252
type: Species
is encoded by: hsa:4047
boundary condition: true
name: LSS
constant: false
is: E9PEI9
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_a17e6c89_d945_4b5e_b2e3_6955178b10b7
boundary condition: true
is encoded by: hsa:65010
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC26A6
has only substance units: false
constant: false
is: Q548A7

metaM cholcoaone x
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: HMDB06891
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial amount: NaN

metaM i c
is: CHEBI:16382
is: HMDB12238
type: Species
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: iodide

metaM cdp n
boundary condition: false
name: CDP(3-)
is: CHEBI:58069
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
is: HMDB01546

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaR DHORTS
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
name: dihydroorotase
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_20e0f198_f39b_440e_94ab_1cb3f8ecada8
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P04075
is encoded by: hsa:226
name: ALDOA

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaR RE3079X
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3079
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

metaR GLNLASEer
product: MODEL1310110043#
fast: false
is: SBO:0000176
name: gluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000

metaR CRNt
name: L-carnitine reversible transport
product: MODEL1310110043#
fast: false
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110043#
is: SBO:0000185

metaM cytd n
is: SBO:0000247
initial amount: NaN
name: cytidine
has only substance units: false
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: HMDB00089
is: CHEBI:17562
constant: false
boundary condition: false
initial concentration: 1.0

metaR DNDPt22m
name: dTDP transport via dUDP antiport
reversible: false
kinetic law: MODEL1310110043#
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_b16e2262_a543_4b32_8348_8a63dc120aff
is: SBO:0000252
is: P17735
name: TAT
initial concentration: NaN
is encoded by: hsa:6898
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM zymstnl r
is: HMDB06841
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
name: 5alpha-cholest-8-en-3beta-ol
is: CHEBI:16608
initial concentration: 1.0
type: Species

metaM arachd c
is: HMDB01043
name: arachidonate
is: SBO:0000247
boundary condition: false
is: CHEBI:32395
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
type: Species

metaR G16MT U
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#
reversible: false
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
type: Reaction

metaM g1p e
type: Species
boundary condition: false
constant: false
is: CHEBI:58601
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: HMDB01586
initial amount: NaN
name: alpha-D-glucose 1-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110043#_7c98352b_5516_49f3_b685_a7fb750f0f85
is: B8ZZR8
is encoded by: hsa:79017
name: GGCT
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM 5aop m
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
name: 5-Amino-4-oxopentanoate
is: HMDB01149
boundary condition: false
has only substance units: false
type: Species
is: C00430
initial concentration: 1.0
is: CHEBI:17549

metaR SEBACIDTD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR S6TASE19ly
reversible: true
reactant: MODEL1310110043#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
type: Reaction

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM cl e
initial amount: NaN
is: HMDB00492
is: C00115
type: Species
notes: FORMULA: Cl CHARGE: -1
boundary condition: false
has only substance units: false
name: Chloride
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:3966

metaM dcmp c
type: Species
initial concentration: 1.0
is: C00239
is: SBO:0000247
is: HMDB01202
is: CHEBI:57566
name: dCMP
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

http://identifiers.org/biomodels.db/MODEL1310110043#_9fad6757_6a8e_4c2d_ac1d_22087fae6ba8
is: Q02218
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: OGDH
is encoded by: hsa:4967

metaM ksi l
name: keratan sulfate I
is: CHEBI:57455
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB01354
constant: false
is: C00445
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
boundary condition: false
has only substance units: false

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
name: isoleucine transaminase, mitochondrial
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
fast: false

metaR CYTK3n
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: cytidylate kinase (dCMP,CTP),nuclear

metaR PCHOL HSter
name: phosphatidylcholine scramblase
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
fast: false
type: Reaction

metaR FADH2tru
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110043#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction

metaR RETFA
fast: false
name: retinol acyltransferase
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaR FAOXC61x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_d8da1e0b_5991_4885_a21a_116e5a4217ee
type: Species
initial concentration: NaN
constant: false
name: HAS2
boundary condition: true
is encoded by: hsa:3037
is: Q92819
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_63220e46_0b1b_4611_8d11_00276be99f41
name: FH
constant: false
initial concentration: NaN
is: P07954
is encoded by: hsa:2271
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaM cmp n
name: CMP(2-)
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
has only substance units: false
constant: false
boundary condition: false
is: HMDB00095
initial amount: NaN
initial concentration: 1.0
type: Species

metaR FAOXC103C102x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_d3456f6e_4ffb_42ea_beae_54cb544995f9
constant: false
initial concentration: NaN
initial amount: NaN
name: PPAT
is encoded by: hsa:5471
is: SBO:0000252
has only substance units: false
is: Q06203
boundary condition: true
type: Species

metaM ksi g
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17140
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01644
name: keratan sulfate I

metaM arg L m
initial amount: NaN
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:32682
type: Species
initial concentration: 1.0

metaR 34HPPte
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
reversible: true
is described by: ECO:0000134
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110043#

metaR r2506
name: Utilized transport
product: MODEL1310110043#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaR FRDPtc
fast: false
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110043#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is described by: ECO:0000000
product: MODEL1310110043#

metaR RE2973C
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.154

metaM ddcacoa x
is: HMDB03571
is: CHEBI:57375
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C01832
initial amount: NaN
boundary condition: false

metaR GNMT
is version of: http://identifiers.org/ec-code/2.1.1.20
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
type: Reaction
name: glycine N-methyltransferase
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
is: SBO:0000176

metaM ksi deg12 l
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00143
name: keratan sulfate I, degradation product 12
initial amount: NaN
constant: false
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
has only substance units: false

metaR BACCLm
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
kinetic law: MODEL1310110043#
reversible: false
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction

metaM 3octdectecoa m
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
initial amount: NaN
name: 3,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaR SEBCOAPET
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_afd7f2f1_2404_4deb_9fb9_ac103ab7160a
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ADH1A
type: Species
is: P07327
constant: false
is encoded by: hsa:124

metaM co2 m
is: C00011
is: HMDB01967
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: SBO:0000247
is: CHEBI:16526
name: CO2
constant: false
initial concentration: 1.0

metaM ksi deg28 l
boundary condition: false
has only substance units: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
constant: false
is: CHEBI:16953
name: keratan sulfate I, degradation product 28
is: SBO:0000247
type: Species
is: HMDB00812
initial concentration: 1.0
initial amount: NaN

metaR r0580
is version of: http://identifiers.org/ec-code/1.3.99.7
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR r0892
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.2.27
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_235d3a75_50ab_4d65_b6a4_89b780adc3f6
constant: false
name: CHAT
has only substance units: false
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN
is: Q6LEN6
boundary condition: true
type: Species
initial amount: NaN

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaM ksi e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:17268
is: HMDB00211
name: keratan sulfate I
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false

metaR r2507
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
reversible: true
name: Utilized transport

metaR NAGLCAly
name: N-acetylglucosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: false
type: Reaction
fast: false

metaR ADNt
modifier: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
name: adenosine facilated transport in cytosol

http://identifiers.org/biomodels.db/MODEL1310110043#_ec265cb2_bc13_45b1_9e12_2f56e6c204cf
is: SBO:0000252
has only substance units: false
name: DGKG
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1608
is: P49619
type: Species

metaM ksi deg41 l
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00143
initial concentration: 1.0
constant: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
boundary condition: false
name: keratan sulfate I, degradation product 41
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110043#_1e7cdfc2_6bc4_4386_9842_5355606f4861
has only substance units: false
name: _AA502753_1_m
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AA502753
is: SBO:0000252

metaR FAOXC61C4x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaM CE2705 c
is: CHEBI:36781
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
name: quinonoid dihydrobiopterin
initial amount: NaN

metaR B3GNT33g
is: SBO:0000176
kinetic law: MODEL1310110043#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#

metaR PEPCK
type: Reaction
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.1.1.32
is: SBO:0000176
name: Phosphoenolpyruvate carboxykinase (GTP)
is described by: ECO:0000134
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
fast: false

metaM gm3 hs g
constant: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: CHEBI:60065
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0
is: SBO:0000247

metaR EX ivcrn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7f24c0b2_35e6_4dfa_a973_784124dc19fe
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P19440
is encoded by: hsa:2678
name: GGT1
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_cccd29d4_dc5e_4ae2_8060_6024f632818a
is: Q92685
boundary condition: true
name: ALG3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10195
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_9798df70_11a4_4941_9f0b_9ee1b16a1167
constant: false
is: P00352
initial amount: NaN
name: ALDH1A1
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:216
initial concentration: NaN

metaR RE3628M
kinetic law: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110043#
fast: false
type: Reaction
reactant: MODEL1310110043#
name: RE3628
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r2508
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#

metaM pail34p hs c
is: CHEBI:57658
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5

metaM i e
is: HMDB12238
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial amount: NaN
is: SBO:0000247
is: CHEBI:16382
initial concentration: 1.0
name: iodide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_3f50ad8b_ce2b_45b4_a247_314b0881837b
has only substance units: false
name: SLC35C1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: B3KQH0
type: Species
is encoded by: hsa:55343

http://identifiers.org/biomodels.db/MODEL1310110043#_73959c49_e8f9_48ca_8c48_509ddd92b136
has only substance units: false
is: P21399
is: SBO:0000252
type: Species
name: ACO1
boundary condition: true
is encoded by: hsa:48
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_de007924_d854_4a4f_bb5b_959fc75408e3
boundary condition: true
is encoded by: hsa:7263
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: TST
is: Q16762
constant: false

metaR B3GNT315g
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000254
reversible: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_2dcd0fbe_3e14_4120_a6e3_328e1eedd681
is: Q6ZWP6
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: ACAD8
is encoded by: hsa:27034

http://identifiers.org/biomodels.db/MODEL1310110043#_c16d875e_29c0_4af9_a799_0902ebec1f8a
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:206
initial amount: NaN
constant: false
name: _206_1_c

metaM gcald c
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: HMDB03344
constant: false
is: CHEBI:17071
initial concentration: 1.0
name: glycolaldehyde
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR r2509
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110043#
fast: false
reversible: true
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110043#
name: Utilized transport

metaM co2 r
is: SBO:0000247
has only substance units: false
is: HMDB01967
is: CHEBI:16526
initial concentration: 1.0
type: Species
name: CO2
boundary condition: false
is: C00011
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
initial amount: NaN

metaR FAOXC204
fast: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 2hb e
has only substance units: false
initial amount: NaN
is: CHEBI:1148
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
name: 2-Hydroxybutyrate
initial concentration: 1.0
is: HMDB00008
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_ca23671b_9162_4fe4_95a3_8d3c3ab79d5e
boundary condition: true
is: P22392
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4831
name: NME2
type: Species
constant: false

metaM cdp e
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01546
type: Species
name: CDP(3-)
boundary condition: false
initial amount: NaN

metaR 5ADTSTSTERONEte
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
name: 5 alpha dihydrotesterone transport

metaR r0960
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
kinetic law: MODEL1310110043#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
fast: false

metaR HKYNH
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.3
reactant: MODEL1310110043#
name: 3-Hydroxy-L-kynurenine hydrolase
product: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
is: SBO:0000176
fast: false

metaM acnam c
constant: false
is: HMDB00230
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: CHEBI:35418

metaM c226coa c
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
name: cervonyl coenzyme A
initial amount: NaN

metaR FAOXC12DCc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR COQ3m
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.1.114
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
product: MODEL1310110043#
fast: false
name: methyltransferase COQ3
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000269

metaM tmndnccoa c
constant: false
is: HMDB06514
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial amount: NaN
name: timnodonyl coenzyme A
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM hgentis c
initial concentration: 1.0
name: homogentisate
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: HMDB00130
is: CHEBI:16169
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_1dc7c514_98e7_4aed_baeb_b3ecdb12ad4d
is encoded by: hsa:759
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P00915
constant: false
has only substance units: false
boundary condition: true
name: CA1

http://identifiers.org/biomodels.db/MODEL1310110043#_8c5aff9c_6cfc_4411_a73c_0c02bb13e530
type: Species
is encoded by: hsa:AI024818
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _AI024818_1_c
initial amount: NaN

metaR DHCRD2
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
name: dihydroceramide desaturase

metaR PHYHx
modifier: MODEL1310110043#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
product: MODEL1310110043#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.11.18
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: Phytanoyl-CoA dioxygenase, peroxisomal

metaR r0584
fast: false
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
reversible: true
type: Reaction

metaM occoa m
constant: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
has only substance units: false
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
boundary condition: false
is: HMDB01070
is: SBO:0000247
is: CHEBI:57386

metaR FAOXC163GC142m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r1640
is: SBO:0000185
modifier: MODEL1310110043#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_4625ee33_44e6_4a29_ac5a_404ab8c60f6a
is encoded by: hsa:8802
initial concentration: NaN
type: Species
name: SUCLG2:SUCLG1
has part: P53597
has only substance units: false
initial amount: NaN
is encoded by: hsa:8801
boundary condition: true
constant: false
has part: Q96I99
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110043#_b821b302_777a_4e23_8a5c_0004fc871717
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:56848
name: SPHK2
is: Q9NRA0
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaR BALAtmr
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: true
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)

metaR OCBTm
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (5009.1) SUBSYSTEM: Urea cycle EC Number: 2.1.3.3 Confidence Level: 4 AUTHORS: PMID:12538786,PMID:6372096 NOTES:TDV
reversible: false
name: ornithine carbamoyltransferase, irreversible
is version of: http://identifiers.org/ec-code/2.1.3.3
is: SBO:0000176

metaM h2o2 x
has only substance units: false
constant: false
is: CHEBI:16240
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Hydrogen peroxide
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: HMDB03125
type: Species

metaR r1641
is described by: ECO:0000000
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR XOLTRIOLtm
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110043#
is: SBO:0000185

metaM 1pipdn2c x
is: HMDB01084
initial amount: NaN
is: CHEBI:16187
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: SBO:0000247
boundary condition: false
name: 1-piperideine-2-carboxylate
constant: false
type: Species

metaM 2hb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
is: SBO:0000247
is: CHEBI:1148
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 2-Hydroxybutyrate
boundary condition: false
is: HMDB00008
constant: false

metaR C141CPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_544e552c_559d_42fe_8a5a_2355c4b1e001
is encoded by: hsa:26
name: ABP1
initial amount: NaN
is: P19801
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false

metaM leuktrA4 c
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
constant: false
name: leukotriene A4(1-)
boundary condition: false
is: CHEBI:57463
has only substance units: false
type: Species
is: HMDB01337
initial concentration: 1.0
initial amount: NaN

metaM ksi deg1 l
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 1
initial concentration: 1.0
is: HMDB00174
constant: false
is: SBO:0000247
is: CHEBI:18287
notes: FORMULA: C241H383N17O209S12X CHARGE: -13

metaM cmpacna n
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57812
constant: false
is: HMDB01176
initial amount: NaN
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM ppcoa m
initial concentration: 1.0
is: CHEBI:57392
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Propanoyl-CoA
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
is: C00100
type: Species

metaM ddcacoa m
is: SBO:0000247
constant: false
is: C01832
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57375
type: Species
is: HMDB03571
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)

metaR NDP8ex
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
type: Reaction
name: nucleoside-diphosphatase (UTP), extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176

metaR r1642
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM naglc2p U c
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18278
initial concentration: 1.0
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog

metaM homoval m
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: Homovanillate
is: CHEBI:545959
is: HMDB00118

metaM m2mpdol U c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
initial concentration: 1.0
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: CHEBI:28049

metaR ARACHDtr
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
name: intracellular transport
reversible: true

metaM ksii core4 l
is: CHEBI:17140
initial amount: NaN
is: HMDB01644
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_0e4b37c2_68bd_46e4_97d4_2326a6791d13
name: PIGN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:23556
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR TTDCAtr
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000269
type: Reaction
name: tetradecanoate (transport)

metaM CE5117 m
is: SBO:0000247
boundary condition: false
is: CHEBI:57923
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR ACP1 FMN
is: SBO:0000176
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
name: acid phosphatase (FMN)
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_d94fdb60_3a29_4e7a_9ba4_f59dbd41464b
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:50808
is: E7ET30
boundary condition: true
constant: false
name: AK3
has only substance units: false

metaR NOt
reactant: MODEL1310110043#
fast: false
reversible: true
name: NO transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_6446beda_06b2_40ac_a59f_0b48d8643251
boundary condition: true
is encoded by: hsa:10050
has only substance units: false
constant: false
is: SBO:0000252
is: Q9Y2C5
type: Species
initial concentration: NaN
name: SLC17A4
initial amount: NaN

metaM cl c
type: Species
is: CHEBI:3966
name: Chloride
is: HMDB00492
is: SBO:0000247
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0
is: C00115
constant: false
boundary condition: false
initial amount: NaN

metaR XYLUR
is described by: ECO:0000269
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
name: xylulose reductase
is version of: http://identifiers.org/ec-code/1.1.1.10
is: SBO:0000176
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:

metaM 44mctr r
is: CHEBI:17813
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01023
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
initial concentration: 1.0
boundary condition: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
type: Species
has only substance units: false

metaR DURIt
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is: SBO:0000185
name: deoxyuridine transport via diffusion
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaM pristcoa x
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: CHEBI:51341
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: pristanoyl coa
has only substance units: false
initial concentration: 1.0
constant: false

metaM m4mpdol U r
constant: false
type: Species
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
has only substance units: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM leuktrA4 e
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: leukotriene A4(1-)
constant: false
is: CHEBI:57463
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01337
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaR r1973
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_f7c51833_a44b_45f8_9e0e_8b1183bc8ec4
boundary condition: true
is encoded by: hsa:3176
name: HNMT
constant: false
has only substance units: false
is: P50135
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_aecf965f_b967_4c04_af22_72d2864bc7aa
boundary condition: true
type: Species
constant: false
is: Q16853
is encoded by: hsa:8639
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: AOC3

metaM cholate e
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:29747
is: SBO:0000247
is: HMDB00619
name: Cholate
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
constant: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR FATP7t
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
fast: false
reversible: true
product: MODEL1310110043#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110043#

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM retn r
is: HMDB01852
is: SBO:0000247
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:35291
constant: false
type: Species

metaM ksi deg1 e
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 1
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:17268
boundary condition: false
is: HMDB00211
initial concentration: 1.0

metaR r0160
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reversible: false
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
modifier: MODEL1310110043#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110043#
fast: false

metaR ACNAM9PL
kinetic law: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.56
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD

metaM dhap e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
type: Species
is: CHEBI:57642
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: glycerone phosphate(2-)
is: HMDB01473

metaR r0587
fast: false
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
product: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_02cbefd9_486d_478b_bd49_94fd3fee50d5
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6649
is: P08294
name: SOD3

metaM co2 x
is: CHEBI:16526
has only substance units: false
is: SBO:0000247
name: carbon dioxide
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_1e54442d_4768_4ec3_b7bc_107c7ac784a5
is: B7Z2T0
initial amount: NaN
boundary condition: true
name: ATP1A3
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:478

metaM C05279 m
is: CHEBI:28387
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: HMDB11123
type: Species
initial concentration: 1.0
is: SBO:0000247
name: trans,cis-Lauro-2,6-dienoyl-CoA
has only substance units: false

metaR UAG4E
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/5.1.3.2
name: UDP-N-acetylglucosamine 4-epimerase
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#
type: Reaction

metaR 3HKYNAKGAT
type: Reaction
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.7
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110043#
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
product: MODEL1310110043#
is: SBO:0000176

metaR S6T8g
modifier: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
fast: false
reversible: false
product: MODEL1310110043#

metaR OCT11EFATP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR RE3567C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
reversible: true
name: RE3567
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000

metaM cholate c
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
constant: false
initial concentration: 1.0
is: HMDB00619
name: Cholate
is: CHEBI:29747

http://identifiers.org/biomodels.db/MODEL1310110043#_26c92265_4f48_4cb5_8aa2_1cb2831435de
is: P34949
name: MPI
boundary condition: true
is encoded by: hsa:4351
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_6db27019_d398_4b73_beeb_a4131b0aec99
initial amount: NaN
is encoded by: hsa:80150
is: SBO:0000252
has only substance units: false
is: Q7L266
boundary condition: true
initial concentration: NaN
constant: false
name: ASRGL1
type: Species

metaR MTHFD
modifier: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM hs deg18 l
type: Species
is: SBO:0000247
is: CHEBI:17180
constant: false
has only substance units: false
is: HMDB01352
name: heparan sulfate, degradation product 18
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM dcmp n
is: SBO:0000247
is: CHEBI:57566
initial concentration: 1.0
type: Species
name: dCMP(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false

metaR FAOXC103C102m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM arachdcrn m
boundary condition: false
initial amount: NaN
is: HMDB01322
type: Species
constant: false
name: C20:4 carnitine
initial concentration: 1.0
has only substance units: false
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247

metaR TRDRm
name: thioredoxin reductase (NADPH)
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d4199832_c8b0_43d6_be02_4ce3ba2715ad
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:374907
is: SBO:0000252
is: Q7Z7M8
name: B3GNT8
constant: false
has only substance units: false

metaM dhap c
is: HMDB01473
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00111
is: SBO:0000247
is: CHEBI:57642

metaR NACHEXA6ly
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
reversible: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
type: Reaction
kinetic law: MODEL1310110043#

metaR TALA
kinetic law: MODEL1310110043#
fast: false
name: transaldolase
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.2.1.2
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP

metaR r1658
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_3f005c81_5684_47bd_9b8c_354fa34fc37f
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4707
is: O75438
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: NDUFB1

http://identifiers.org/biomodels.db/MODEL1310110043#_c0a6f749_326b_488a_a0b4_3230c47067b9
has only substance units: false
is encoded by: hsa:AGPAT7
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: _AGPAT7_1_c

http://identifiers.org/biomodels.db/MODEL1310110043#_938a2a6c_e21d_434e_bbdf_c4d9cfffa177
constant: false
initial concentration: NaN
name: DYLX2
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: F5H123
is encoded by: hsa:9856

http://identifiers.org/biomodels.db/MODEL1310110043#_5a859645_40db_4cb7_a778_b0f67c26f495
name: ST3GAL1
is: SBO:0000252
is encoded by: hsa:6482
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM dhcholestanate r
constant: false
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00359
is: SBO:0000247
boundary condition: false

metaR GPDDA1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
is: SBO:0000176
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
reversible: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000

metaR NRPPHRSFt
fast: false
name: norepinephrine sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
reversible: false

metaR NACHEX5ly
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
product: MODEL1310110043#
modifier: MODEL1310110043#

metaM limnen c
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
initial amount: NaN
is: HMDB03375
name: limonene
is: CHEBI:15384
initial concentration: 1.0
boundary condition: false

metaM c8dc x
constant: false
type: Species
has only substance units: false
is: HMDB00893
name: suberyl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
initial amount: NaN

metaM 4abut e
is: SBO:0000247
is: C00334
is: CHEBI:3628
constant: false
name: 4-Aminobutanoate
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112

metaM 3ddecdicoa m
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 3,6-dodecadienoylcoa
type: Species
boundary condition: false
is: C05280
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: HMDB03952
is: SBO:0000247

metaR r2088
modifier: MODEL1310110043#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaM pail45p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28910
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
type: Species

metaR r1657
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaM cbasp c
boundary condition: false
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814
is: C00438
initial concentration: 1.0
is: HMDB00828
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_16c915a3_82bd_4cd3_aa63_3aa5465de383
name: NDUFS2
is encoded by: hsa:4720
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: B7Z792
initial amount: NaN

metaR DHEASULT
is version of: http://identifiers.org/ec-code/2.8.2.4
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: Dehydroepiandrosterone sulfotransferase
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6783.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:1588921 NOTES:NJ
type: Reaction
fast: false

metaM cdp c
is: C00112
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
initial concentration: 1.0
name: CDP
boundary condition: false
constant: false
is: CHEBI:58069

metaR GLCNACASE1ly
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_1b9cc999_a511_4f91_9652_a59e8596c7fa
constant: false
is encoded by: hsa:347734
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC35B2
initial concentration: NaN
type: Species
boundary condition: true
is: Q8TB61

metaM pydx c
has only substance units: false
is: HMDB01545
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: C00250
is: SBO:0000247
constant: false
is: CHEBI:17310
name: Pyridoxal
boundary condition: false

metaM arachd x
is: CHEBI:32395
constant: false
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
has only substance units: false
initial concentration: 1.0
name: arachidonate
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaR FAOXC161802m
product: MODEL1310110043#
name: Beta oxidation fatty acid
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176

metaR C102CPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_42b10af7_f278_4ede_8ab5_0b625320b4af
is: SBO:0000252
is: A8K761
type: Species
constant: false
initial amount: NaN
name: NDUFB10
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4716
boundary condition: true

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7d0a6075_f52a_414b_9f88_a6143d989825
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4696
name: NDUFA3
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: O95167

metaR G14T8g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
type: Reaction

metaM fdp c
is: http://identifiers.org/pubchem.compound/3647
is: C00354
is: CHEBI:16905
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: HMDB01058
initial concentration: 1.0
type: Species
name: D-Fructose 1,6-bisphosphate
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false

metaR EX dca LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Decanoate (n-C10:0) exchange
type: Reaction

metaM utp e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
is: CHEBI:46398
initial amount: NaN
constant: false
is: HMDB00285

metaR r2087
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#

metaR GLYCt
fast: false
type: Reaction
name: glycerol transport via channel
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD

metaR FACOAL1821
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
type: Reaction
modifier: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
reversible: true
fast: false
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_ef08f941_382b_4c74_89e2_bebc93030792
is: SBO:0000252
constant: false
name: _AA676725_1_c
is encoded by: hsa:AA676725
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7da34e80_c437_47e8_8851_1c98678554bd
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6818
name: SULT1A3
has only substance units: false
constant: false
boundary condition: true

metaR r1656
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#

metaM tdchola e
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: taurochenodeoxycholate
is: HMDB00951
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407

metaM 4abut c
is: CHEBI:3628
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
name: 4-Aminobutanoate
is: SBO:0000247
type: Species
is: HMDB00112

metaM dec24dicoa m
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 2,4-decadienoylcoa
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
is: HMDB01168

http://identifiers.org/biomodels.db/MODEL1310110043#_089d69e9_14f1_45d5_84be_eec806a01b9a
initial amount: NaN
name: PCBD1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5092
initial concentration: NaN
type: Species
has only substance units: false
is: P61457
constant: false

metaR r2086
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_64cde188_2263_43c2_91fc_7889b64be6bb
is: O95573
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: ACSL3
has only substance units: false
constant: false
is encoded by: hsa:2181

metaR DOPAt4 2 r
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110043#
name: Dopamine reversible transport in via sodium symport (1:2)
type: Reaction
reversible: true
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
modifier: MODEL1310110043#
is described by: ECO:0000269

metaM dpcoa e
is: HMDB01373
boundary condition: false
constant: false
type: Species
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: CHEBI:57328
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Dephospho-CoA
is: SBO:0000247

metaM CE1944 c
is: SBO:0000247
has only substance units: false
is: CHEBI:36781
constant: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 1-pyrrolinium

http://identifiers.org/biomodels.db/MODEL1310110043#_cbd899ea_129c_466c_b80b_7a597d6fdc77
is encoded by: hsa:6785
has only substance units: false
name: ELOVL4
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9GZR5
type: Species
is: SBO:0000252

metaR r1655
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#

metaR FACOAL1822
type: Reaction
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
name: fatty-acid--CoA ligase

metaR UDPtl
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
name: udp intracellular transport
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR 34DHOXPEGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110043#
fast: false

metaR r0774
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
type: Reaction

metaR ACNAMlt
name: N-acetylneuraminate transport into lysososme
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM utp c
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP
boundary condition: false
is: SBO:0000247
is: C00075
type: Species
is: CHEBI:46398
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00285

metaR r2085
modifier: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110043#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110043#

metaM udpglcur r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
is: C00167
is: CHEBI:58052
boundary condition: false
type: Species
name: UDP-D-glucuronate
has only substance units: false
initial amount: NaN
constant: false

metaR ACRNtm
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
reactant: MODEL1310110043#
type: Reaction
fast: false
name: O-acetylcarnintine transport into mitochondria via diffusion
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#

metaR FAOXC2442246x
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
type: Reaction
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false

metaR r0578
is: SBO:0000176
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.1.2.27
reversible: true

metaM didp n
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: dIDP
is: CHEBI:28823
has only substance units: false
type: Species
constant: false
boundary condition: false

metaR NTD9e
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000254
modifier: MODEL1310110043#
name: 5'-nucleotidase (GMP), extracellular
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:16325434 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110043#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_dd7b2e8f_d294_4283_9711_b31b3c86f7dd
is: P48448
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:222
type: Species
name: ALDH3B2
is: SBO:0000252
initial concentration: NaN

metaR FAOXC81C61x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_13ab54ba_0063_402f_bb4a_6d00bae5d7f9
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: O43175
name: PHGDH
is encoded by: hsa:26227
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR RE3244R
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
is: SBO:0000176
name: RE3244
kinetic law: MODEL1310110043#
fast: false
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaM dpcoa c
constant: false
initial concentration: 1.0
is: HMDB01373
has only substance units: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
name: Dephospho-CoA
initial amount: NaN
is: C00882
is: CHEBI:57328
is: SBO:0000247
boundary condition: false

metaR r2084
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110043#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185

metaM tmndnccoa m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
initial amount: NaN
is: HMDB06514
name: timnodonyl coenzyme A
type: Species
boundary condition: false
has only substance units: false

metaR ASNALANaEx
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110043#
reversible: false
product: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000185
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)
reactant: MODEL1310110043#
fast: false

metaR ACGALtly
product: MODEL1310110043#
reactant: MODEL1310110043#
name: N-acetyl-galactosamine lysosomal efflux
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reversible: false

metaR r0579
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.13.11.19
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a4028dac_fa63_4576_8336_7f05475ed83f
initial amount: NaN
is: Q9GZS9
initial concentration: NaN
type: Species
is encoded by: hsa:23563
boundary condition: true
constant: false
name: CHST5
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_701c3edb_a969_4974_b5ea_99d8627d657e
initial amount: NaN
name: _AA576959_1_c
is encoded by: hsa:AA576959
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM dgsn m
has only substance units: false
is: SBO:0000247
name: Deoxyguanosine
is: CHEBI:17172
is: HMDB00085
boundary condition: false
is: C00330
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330

metaR r2083
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: true
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

metaM dtmp m
is: CHEBI:26999
is: SBO:0000247
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
is: HMDB01227
initial amount: NaN
boundary condition: false
is: C00364
initial concentration: 1.0
has only substance units: false
constant: false

metaR UGT1A10r
is described by: ECO:0000134
kinetic law: MODEL1310110043#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false

metaR MANt4
reversible: true
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
name: D-mannose transport via sodium cotransport
is described by: ECO:0000269
reactant: MODEL1310110043#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110043#
product: MODEL1310110043#

metaR AG13T6g
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR r0779
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR RE1836X
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
name: RE1836
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
product: MODEL1310110043#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR S6T13g
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110043#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110043#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_0fedd3b5_98ed_442d_95ae_9fb81baf7096
constant: false
initial amount: NaN
is encoded by: hsa:5091
is: SBO:0000252
boundary condition: true
type: Species
name: PC
initial concentration: NaN
has only substance units: false

metaM ptdcacoa m
is: HMDB06499
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
name: pentadecanoyl Coenzyme A

metaR FAOXC22C20x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22-->C20)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5fabc24c_23ab_4a39_a4c4_e7adf8a52ffa
is: P46952
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23498
name: HAAO
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_62a53817_f98d_4a11_ad31_72e37942b6b4
constant: false
is encoded by: hsa:5293
is: A7E2E0
is: SBO:0000252
name: PIK3CD
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7797ae66_006e_400f_be52_b6befa9514fd
is: SBO:0000252
is encoded by: hsa:4538
initial concentration: NaN
is: P03905
boundary condition: true
has only substance units: false
name: ND4
type: Species
constant: false
initial amount: NaN

metaM ksi pre4 g
is: HMDB00175
type: Species
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 4
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: C00130
is: CHEBI:58053
notes: FORMULA: C101H165N7O72X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110043#_0619dafb_aa14_49d0_917a_4bc503396d34
name: SLC43A2
is encoded by: hsa:124935
boundary condition: true
is: Q8N370
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252

metaR TYROXDAc
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
product: MODEL1310110043#
reversible: false

metaR PNTK
product: MODEL1310110043#
is: SBO:0000176
name: pantothenate kinase
kinetic law: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d5f7ca31_f472_4287_adb0_7a2bf5f240fb
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: O14732
initial concentration: NaN
is encoded by: hsa:3613
has only substance units: false
name: IMPA2
initial amount: NaN

metaR OCTDECCPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_13a23ab8_4949_422c_8e71_d1b102b4cd86
initial concentration: NaN
name: SLC36A1
has only substance units: false
constant: false
is: Q1LZ56
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:206358
is: SBO:0000252

metaR DNDPt11m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dGDP antiport
is: SBO:0000185
reactant: MODEL1310110043#

metaM limnen e
has only substance units: false
initial concentration: 1.0
is: HMDB03375
initial amount: NaN
name: limonene
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:15384

http://identifiers.org/biomodels.db/MODEL1310110043#_e07216b4_d3fa_4bf5_9ae5_90cd9ee563f5
type: Species
boundary condition: true
is encoded by: hsa:5634
initial amount: NaN
is: SBO:0000252
name: PRPS2
constant: false
is: P11908
has only substance units: false
initial concentration: NaN

metaR r2082
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_47962ce3_37d8_4393_87ad_8d7d11f6e10e
initial amount: NaN
has only substance units: false
is: P06744
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2821
name: GPI
is: SBO:0000252
type: Species
constant: false

metaM ksi pre8 g
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 8
has only substance units: false
boundary condition: false

metaM 3htdcoa c
constant: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
is: HMDB02014
boundary condition: false
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaM cbasp e
is: CHEBI:32814
constant: false
is: SBO:0000247
is: HMDB00828
initial concentration: 1.0
type: Species
name: N-Carbamoyl-L-aspartate
initial amount: NaN
is: C00438
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2

metaR r1659
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000

metaM dad 2 c
name: 2-deoxyadenosine
is: HMDB00101
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17256
boundary condition: false
type: Species
has only substance units: false

metaR OCTDECCPT2
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR FAOXC164x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM cit m
boundary condition: false
initial concentration: 1.0
is: C00158
is: CHEBI:16947
name: Citrate
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
is: HMDB00094
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_94a71dc8_9729_482f_bff3_dd7a5c172010
has only substance units: false
initial amount: NaN
is encoded by: hsa:51022
name: GLRX2
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true

metaR r2081
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
reversible: true
modifier: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM tddedi2coa m
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00792
is: C08277
initial concentration: 1.0
name: trans2,6dodecadienoylcoa
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110043#_b2820552_759f_4b0e_b485_6d508ac5bd34
constant: false
is encoded by: hsa:M68895
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _M68895_1_c
has only substance units: false
boundary condition: true

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_952bae6c_e76f_47b7_9970_4e325f301a8c
initial concentration: NaN
constant: false
is: P27707
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1633
initial amount: NaN
boundary condition: true
name: DCK

metaM htaxol e
type: Species
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1
is: SBO:0000247
boundary condition: false
is: HMDB02259
is: CHEBI:32366
initial amount: NaN
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
has only substance units: false
constant: false
initial concentration: 1.0

metaM nrpphrsf c
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02062
initial amount: NaN
name: Sulfate derivative of norepinephrine
constant: false
type: Species

metaR RE1522M
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
name: RE1522
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR PROt2r
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
is described by: ECO:0000304
reversible: true
fast: false
name: L-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_57896534_3264_4901_ac20_59f0ee7f7efa
name: CA12
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:771
boundary condition: true

metaR ARGtm
modifier: MODEL1310110043#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: arginine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_df356d9a_1286_4e56_8798_5edaa631a353
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:3283
is: SBO:0000252
is: P14060
name: HSD3B1
boundary condition: true

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00191
is: CHEBI:29991
initial concentration: 1.0
name: L-aspartate(1-)
has only substance units: false
type: Species

metaM occoa x
is: SBO:0000247
initial amount: NaN
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
is: CHEBI:57386
type: Species
is: C01944
constant: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial concentration: 1.0
boundary condition: false

metaR BAAT2x
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
is: SBO:0000176
type: Reaction
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_03ae5f0f_6361_40ed_9ef4_f818f84ee418
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3291
type: Species
name: HSD11B2
is: P80365
constant: false
is: SBO:0000252
initial concentration: NaN

metaM ade c
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
name: Adenine
has only substance units: false
boundary condition: false
is: CHEBI:16708
is: HMDB00034
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00147
is: SBO:0000247

metaR GBA
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: Glucosylceramidase
is version of: http://identifiers.org/ec-code/3.2.1.45
reactant: MODEL1310110043#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
modifier: MODEL1310110043#
reversible: false
type: Reaction

metaR r0885
kinetic law: MODEL1310110043#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_49c0d67f_4362_4c4a_b0c3_13844fad03e4
type: Species
constant: false
initial concentration: NaN
name: CYP1A1
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1543
is: A0N0X8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_b3ac4256_b9e4_479f_9acd_212fe2a958b5
is encoded by: hsa:116285
initial amount: NaN
name: ACSM1
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q08AH1
has only substance units: false

metaM dpcoa m
is: SBO:0000247
is: CHEBI:57328
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d632c040_b551_4c07_860b_f16a3f26abe5
initial amount: NaN
constant: false
is: SBO:0000252
is: P55809
is encoded by: hsa:5019
type: Species
name: OXCT1
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_37a25530_95c9_47c4_b5a9_620d8aa29d29
is: O00217
is: SBO:0000252
name: NDUFS8
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4728
constant: false
boundary condition: true
initial amount: NaN

metaM didp c
constant: false
is: HMDB03536
boundary condition: false
initial concentration: 1.0
name: dIDP
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
is: CHEBI:28823
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_a8252da3_b4c5_45d2_aa76_5451be6d6a1b
is encoded by: hsa:7296
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: TXNRD1
initial amount: NaN

metaR ACITL
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.3.8
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
name: ATP-Citrate lyase
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2b734309_516b_41da_ae76_09d8cf41a510
boundary condition: true
type: Species
name: PIGF
is encoded by: hsa:5281
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q6IB04

http://identifiers.org/biomodels.db/MODEL1310110043#_44661153_37ed_46a0_a067_2cf766e1c734
constant: false
has only substance units: false
name: ACP6
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9NPH0
boundary condition: true
is encoded by: hsa:51205

metaM HC01405 m
initial concentration: 1.0
constant: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:28632
name: (S)-Hydroxyoctanoyl-CoA
type: Species

metaR SPODMm
name: superoxide dismutase
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
is: HMDB00257
is: CHEBI:16094
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0

metaR FUMSO4tm
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfate antiport, mitochondrial
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_3ae59c0e_7c23_4616_96cd_0669ccb8b042
name: NME4
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4833
is: O00746
boundary condition: true
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_67c51039_f7c1_4e59_bc68_9884d435532c
boundary condition: true
initial amount: NaN
name: ND3
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4537
is: SBO:0000252
is: P03897

metaR FUT16g
is version of: http://identifiers.org/ec-code/2.4.1.69
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
product: MODEL1310110043#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110043#
type: Reaction
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1

http://identifiers.org/biomodels.db/MODEL1310110043#_c180663f_825d_4414_b4e8_5b592d98f767
has only substance units: false
initial amount: NaN
name: DGAT1
boundary condition: true
is: O75907
type: Species
is encoded by: hsa:8694
is: SBO:0000252
initial concentration: NaN
constant: false

metaR HACD9m
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000134
kinetic law: MODEL1310110043#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_f87fae91_028a_467e_831e_d37a262e71b0
is encoded by: hsa:79071
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: Q9H5J4
type: Species
name: ELOVL6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_838d5488_3847_4c99_a884_85a352ebffe1
is: SBO:0000252
is: Q14542
name: SLC29A2
is encoded by: hsa:3177
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM nrpphrsf e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial concentration: 1.0
initial amount: NaN
is: HMDB02062
has only substance units: false
constant: false
name: Sulfate derivative of norepinephrine
type: Species
is: http://identifiers.org/pubchem.compound/123747

metaR C121CPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR CRNtim
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
kinetic law: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110043#
is: SBO:0000185
name: L-carnitine transport out of mitochondria via diffusion
reactant: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#

metaR RE3050R
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: RE3050
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
kinetic law: MODEL1310110043#

metaM ade e
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
name: adenine
has only substance units: false
is: HMDB00034
is: CHEBI:16708
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR AKR1D2
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269
product: MODEL1310110043#

metaR P5CRm
type: Reaction
name: pyrroline-5-carboxylate reductase (m)
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000304
fast: false
reactant: MODEL1310110043#

metaR r0129
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110043#

metaR GGH 7DHFe
is: SBO:0000176
reversible: false
modifier: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110043#
fast: false
name: Gamma-glutamyl hydrolase (7DHF), extracellular
type: Reaction
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_2c30af96_1947_448b_85e8_d481a87a77e1
name: TXNRD1
is encoded by: hsa:7296
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR FAOXC3DC
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaM arachd r
has only substance units: false
name: arachidonate
type: Species
constant: false
is: CHEBI:32395
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
initial concentration: 1.0
is: HMDB01043
boundary condition: false

metaR r0122
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
is: SBO:0000176

metaR ABTD
name: L-arabinitol 4-dehydrogenase
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is: SBO:0000176
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
fast: false

metaR M16NTg
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
kinetic law: MODEL1310110043#
is: SBO:0000176
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
reversible: false
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.143
is described by: ECO:0000000

metaM dhap x
has only substance units: false
is: SBO:0000247
is: CHEBI:57642
is: C00111
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
name: Dihydroxyacetone phosphate
initial amount: NaN

metaR SERGLYexR
fast: false
reversible: true
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glycine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110043#_4b40579f_b35b_420b_8583_45bfa1487133
type: Species
name: _AI684467_1_m
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI684467
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM sebacid c
has only substance units: false
boundary condition: false
initial amount: NaN
is: C08277
type: Species
is: SBO:0000247
notes: FORMULA: C10H16O4 CHARGE: -2
constant: false
is: HMDB00792
name: sebacicacid
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_88549433_a289_47ac_afad_95c9bd45f167
type: Species
name: _7359_1_c
initial amount: NaN
is encoded by: hsa:7359
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM tdchola c
initial amount: NaN
is: HMDB00951
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:9407
name: taurochenodeoxycholate
has only substance units: false
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247

metaR EX c16dc
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaM dtmp c
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: CHEBI:26999
is: HMDB01227
is: C00364
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: dTMP
initial concentration: 1.0

metaR GALASE16ly
modifier: MODEL1310110043#
product: MODEL1310110043#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110043#

metaR r0276
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
reactant: MODEL1310110043#
reversible: true

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
type: Reaction
kinetic law: MODEL1310110043#
fast: false
reversible: true
product: MODEL1310110043#
name: sph1p transport
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
constant: false
has only substance units: false
name: dTMP(2-)
type: Species
initial amount: NaN
is: CHEBI:26999
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR DCSPTN1CRNt
type: Reaction
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110043#
is: SBO:0000185

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

metaM dhcholestanate x
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:16577
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
boundary condition: false

metaM dpcoa l
initial amount: NaN
is: CHEBI:57328
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false
is: HMDB01373
is: SBO:0000247
has only substance units: false
name: 3'-dephospho-CoA(2-)
constant: false
type: Species

metaR r0881
type: Reaction
fast: false
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
reversible: false
kinetic law: MODEL1310110043#
name: Active transport
reactant: MODEL1310110043#

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR GLCt2 2
is: SBO:0000185
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
name: D-glucose transport in via proton symport
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
is described by: ECO:0000269
type: Reaction
fast: false

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR DNDPt26m
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
name: dCDP transport via dUDP antiport
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110043#_48aa3ce9_31d3_499f_a5a1_838b048c4f0f
initial concentration: NaN
is encoded by: hsa:LOC374569
is: SBO:0000252
initial amount: NaN
constant: false
name: _LOC374569_1_e
type: Species
has only substance units: false
boundary condition: true

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaM arachd l
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species
is: SBO:0000247
constant: false
is: HMDB01043
name: arachidonate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR EX adp
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_cc343768_4842_4057_81f8_1b310b11e115
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5147
initial amount: NaN
boundary condition: true
name: PDE6D
is: O43924
has only substance units: false

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaR LGNCCOAtx
kinetic law: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
fast: false
name: fatty acid intracellular transport
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3667a26f_92d5_4064_b320_afb998c29328
type: Species
is: SBO:0000252
has only substance units: false
name: ADHFE1
is: Q8IWW8
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:137872

metaR FAOXTC182TC162m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_9bc3c451_04a2_435c_91a1_bef8ff2bae2d
type: Species
name: B3GNT8
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:374907
boundary condition: true

metaR ADNCYC
is version of: http://identifiers.org/ec-code/4.6.1.1
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110043#
name: adenylate cyclase

http://identifiers.org/biomodels.db/MODEL1310110043#_48c6b970_d500_47bc_bb16_b57f1f0b6630
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AI640625
name: _AI640625_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM HC01223 m
is: SBO:0000247
initial amount: NaN
is: CHEBI:57340
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
type: Species
boundary condition: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_780eefb9_b633_4633_9de4_e7272d2f0364
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1716
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: DGUOK

metaM pail45p hs n
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_06795a8f_da73_4f32_a36b_169d3f61210e
initial amount: NaN
is: SBO:0000252
is: Q92959
type: Species
is encoded by: hsa:6578
initial concentration: NaN
boundary condition: true
name: SLCO2A1
constant: false
has only substance units: false

metaR LTD4DP
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
kinetic law: MODEL1310110043#
name: Leukotriene D4 dipeptidase
reversible: true
product: MODEL1310110043#
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction

metaM htaxol c
notes: FORMULA: C47H31NO15 CHARGE: 0 INCHI: InChI=1/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45+,46-,47-/m1/s1
is: CHEBI:28815
boundary condition: false
constant: false
name: 6 alpha hydroxy taxol/ 6 alpha hydroxy paclitaxel
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaR 3MOBte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110043#
fast: false
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
name: Transport of 3-methyl-2-oxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110043#_535ebe2d_de8f_4e3b_a454_e02a3f2b8823
is: P56937
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: HSD17B7
boundary condition: true
is encoded by: hsa:51478
initial concentration: NaN

metaM dhbpt c
name: 6,7-dihydrobiopterin
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:20680
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ab4a8cef_9ac0_4cb8_8d41_c16889d639c6
initial amount: NaN
type: Species
name: ECH1
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1891
is: Q13011

metaR r2089
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_f9c74abd_6d8c_4a6a_b258_9ebe888acdd5
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1586
name: CYP17A1
initial amount: NaN
is: P05093

metaR GLCtg
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: true
type: Reaction
name: glucose transport, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110043#_6dc34ec7_7d7b_4817_b5e9_24f99766b0a2
is encoded by: hsa:2530
is: SBO:0000252
name: FUT8
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: A8K8P8

http://identifiers.org/biomodels.db/MODEL1310110043#_3573ee51_06db_4736_8093_9bca13ab43b6
boundary condition: true
is encoded by: hsa:3422
initial amount: NaN
is: Q13907
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: IDI1
has only substance units: false

metaM pail45p hs m
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
boundary condition: false
initial concentration: 1.0

metaR APOC LYS BTNP
reversible: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110043#
name: proteolysis of apoC-Lys-btn
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_64b7d358_1feb_49b9_95e9_4ef7c83a790c
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:23428
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC7A8
constant: false
is: Q9UHI5

metaM retinal c
is: SBO:0000247
is: HMDB01358
constant: false
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
name: retinal
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:15035
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_47e61bdd_3acf_4463_a370_943f2d97c75d
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:518
name: ATP5G3

http://identifiers.org/biomodels.db/MODEL1310110043#_63c2e321_1336_455f_9b61_12072f1824f2
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:257068
is: Q0VAA5
initial concentration: NaN
name: PLCXD2
has only substance units: false
type: Species

metaM asp L e
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
is: CHEBI:29991
is: HMDB00191
name: L-aspartate(1-)
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM dhcholestanate c
constant: false
initial amount: NaN
type: Species
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX 3bcrn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy butyryl carnitine
type: Reaction

metaR r0998
fast: false
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000
name: Facilitated diffusion

metaM pydxn c
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: Pyridoxine
is: CHEBI:16709
is: SBO:0000247
is: HMDB00239
type: Species
is: C00314
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_2c09af95_7408_47fc_b6fe_5a10d9dea2a1
initial amount: NaN
is encoded by: hsa:5294
type: Species
initial concentration: NaN
has part: P48736
is encoded by: hsa:10870
name: HCST:PIK3CG
boundary condition: true
has only substance units: false
has part: Q9UBK5
is: SBO:0000297
constant: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR HSD11B2r
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.146
reactant: MODEL1310110043#
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
name: 11-beta-hydroxysteroid dehydrogenase type 2
type: Reaction

metaM glyb c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17750
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
name: glycine betaine
has only substance units: false
is: HMDB00043
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_020a232b_b79b_4be2_b07f_518a19f65982
has only substance units: false
is: SBO:0000297
is encoded by: hsa:55350
has part: A8K7W0
constant: false
has part: O95497
initial amount: NaN
is encoded by: hsa:8876
initial concentration: NaN
type: Species
boundary condition: true
name: VNN3:VNN2:VNN1
is encoded by: hsa:8875

metaR IDOAASE3ly
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_d0ac6a8b_1791_43dd_89e2_c523c36e0cdf
type: Species
has only substance units: false
initial amount: NaN
name: _W87865_1_c
constant: false
boundary condition: true
is encoded by: hsa:W87865
is: SBO:0000252
initial concentration: NaN

metaM 3htdcoa m
has only substance units: false
is: HMDB02288
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM tdchola x
boundary condition: false
constant: false
name: taurochenodeoxycholate
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:9407
is: HMDB00951

metaM pro L m
is: CHEBI:17203
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: L-proline
has only substance units: false
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0

metaR GPIMTer U
type: Reaction
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
product: MODEL1310110043#

metaM prostgd2 r
name: prostaglandin D2(1-)
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
has only substance units: false
is: HMDB01403
initial amount: NaN
is: CHEBI:57406
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_432bf76f_1c37_4007_8baf_2bd70865d5f9
initial concentration: NaN
is encoded by: hsa:517
is: Q06055
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: ATP5G2
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_ac8e6fe5_26d4_450b_8572_4122c32bbba6
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: HMGCS1
is encoded by: hsa:3157
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_5c14605c_68d0_423b_9cba_4c85f367a934
name: QDPR
is encoded by: hsa:5860
initial amount: NaN
type: Species
is: P09417
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaR DALAt2r
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
product: MODEL1310110043#
name: D-alanine transport via proton symport

metaR PNTEH
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
name: Hydrolase Class ( RXN R02973)
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false

metaR r0999
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Facilitated diffusion
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#

metaR UMPK5n
name: UMP kinase (dATP),nuclear
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269

metaR CSPG Ctly
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
name: chondroitin sulfate C transport, extracellular to lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: false
fast: false

metaR EX tolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tolbutamide exchange
type: Reaction

metaM mal L e
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial concentration: 1.0
is: SBO:0000247
name: (S)-malate(2-)
is: CHEBI:15589
type: Species
is: HMDB00156
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_34b64fa8_b435_4fea_9c3f_54b753fad842
is: SBO:0000252
constant: false
type: Species
is: Q92781
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5959
has only substance units: false
boundary condition: true
name: RDH5

http://identifiers.org/biomodels.db/MODEL1310110043#_52cae40d_93f2_481b_8e61_21e0220aceb1
constant: false
is encoded by: hsa:R51273
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _R51273_1_c
boundary condition: true

metaM dgsn c
is: CHEBI:17172
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00085
constant: false
is: C00330

metaR EX carveol LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (E)-carveol exchange
type: Reaction

metaR r0424
reversible: true
type: Reaction
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaM asp L c
constant: false
name: L-aspartate(1-)
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:29991
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191

metaR GALSIDEtg
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#
name: galactocerebroside intracellular transport
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_4a114a81_a873_4420_87c2_03dd383ab6a5
is: P11182
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1629
constant: false
is: SBO:0000252
boundary condition: true
name: DBT
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_11828527_4699_493a_b425_dd5f8ff9d81c
initial amount: NaN
initial concentration: NaN
name: ACOT1
has only substance units: false
boundary condition: true
is encoded by: hsa:641371
is: E9KL42
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_63b48650_0cd4_4fa2_917d_6994eab54ffa
has only substance units: false
is: SBO:0000252
boundary condition: true
name: PPA2
type: Species
constant: false
is: F8WDN9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110043#_a5dd15e5_a0b0_4729_a5ac_167da8e85caf
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6307
name: MSMO1
initial amount: NaN
has only substance units: false
is: A8MYF6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_1f04fb9a_4898_452c_b7b3_d50ee448c30f
name: _AI222095_1_e
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI222095
type: Species

metaR TDPm
type: Reaction
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
name: thiamin pyrophosphatase, mitochondrial
is: SBO:0000176
product: MODEL1310110043#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d676d877_0cab_489d_bbb2_e234875f1b85
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56606
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: SLC2A9

metaM tmndnccoa x
name: timnodonyl coenzyme A
constant: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM udpglcur c
has only substance units: false
constant: false
name: UDP-D-glucuronate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
is: HMDB00935
initial concentration: 1.0
is: CHEBI:58052
initial amount: NaN
type: Species

metaM pail hs n
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57880
type: Species
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0

metaM ascb L e
initial amount: NaN
is: CHEBI:38290
boundary condition: false
is: SBO:0000247
is: HMDB00044
constant: false
name: L-ascorbate
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_af0641a5_f61b_4c34_96b4_7ecc092e7dff
is encoded by: hsa:38
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACAT1
constant: false
is: P24752
has only substance units: false
type: Species
initial amount: NaN

metaR r0423
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110043#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110043#
type: Reaction

metaR OMHPALTD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM gluala e
is: SBO:0000247
is: C03740
constant: false
has only substance units: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
boundary condition: false
is: HMDB06248

http://identifiers.org/biomodels.db/MODEL1310110043#_5fda3243_5276_43e1_aa73_bd55fca2a413
initial concentration: NaN
type: Species
name: SLC7A10:SLC3A2
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:6520
has part: P08195
has only substance units: false
has part: Q9NS82
is encoded by: hsa:56301

metaM caro e
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
type: Species
constant: false
is: CHEBI:17579
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: beta-carotene
has only substance units: false
is: HMDB00561

metaM mal L c
initial amount: NaN
name: (S)-malate(2-)
is: SBO:0000247
is: CHEBI:15589
boundary condition: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
constant: false
is: HMDB00156
initial concentration: 1.0

metaR SPODMe
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
is: SBO:0000176
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: false
fast: false
type: Reaction
name: superoxide dismutase, extracellular
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1

metaR DMATTx
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
name: dimethylallyltranstransferase
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
is: SBO:0000176

metaR RETHe
reversible: false
name: retinyl ester hydrolase, extracellular
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_eda68867_89c9_4134_9170_5f36eaac0a46
initial amount: NaN
is encoded by: hsa:5373
initial concentration: NaN
has only substance units: false
is: O15305
constant: false
is: SBO:0000252
name: PMM2
type: Species
boundary condition: true

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.34
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_8ed6cd21_9a0a_4a6d_8993_0ce45d603cd1
has only substance units: false
is encoded by: hsa:5277
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: Q14442
is encoded by: hsa:51227
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8818
type: Species
initial amount: NaN
has part: O94777
is encoded by: hsa:9091
has part: B3KUV7
has part: Q9BRB3
has part: Q92535
constant: false
is encoded by: hsa:5279
is encoded by: hsa:5283
is: SBO:0000297

metaR r1946
type: Reaction
modifier: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#

metaM dcsptn1crn m
is: HMDB06321
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_3142797e_951d_4f77_9e33_a94da8dd6657
is encoded by: hsa:1854
is: P33316
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: DUT

metaR FACOAL224
is: SBO:0000176
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
reversible: true
fast: false
reactant: MODEL1310110043#

metaR PI4P3K
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4-phosphate 3-kinase
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_3c7dc288_14c3_4ffd_abe3_dbd28e4aec21
type: Species
constant: false
name: GALNT5
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: A5PKZ1
boundary condition: true
is encoded by: hsa:11227
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_51750710_3f76_4bc0_810a_090d54d005bb
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:55902
initial amount: NaN
is: Q5QPH3
is: SBO:0000252
name: ACSS2
has only substance units: false

metaR RE3245C
type: Reaction
reactant: MODEL1310110043#
name: RE3245
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton

metaM c101coa c
name: decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
is: HMDB00651
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaM ascb L c
type: Species
is: CHEBI:38290
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00044
name: L-ascorbate
constant: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_de9af1ae_7821_4b01_bda1_04bc73c2f098
initial concentration: NaN
is encoded by: hsa:51703
initial amount: NaN
name: ACSL5
is: SBO:0000252
constant: false
has only substance units: false
is: Q9ULC5
type: Species
boundary condition: true

metaM HC02179 c
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
name: 20-hydroxy-arachidonate
has only substance units: false
is: CHEBI:34306
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_0bf24a24_54d8_4804_8d08_df71bbbd195c
initial concentration: NaN
has only substance units: false
is: E9KL44
type: Species
name: HADHA
is encoded by: hsa:3030
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM 3hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB02288
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR FACOAL226
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
reversible: true
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000

metaM 5eipencoa m
is: SBO:0000247
has only substance units: false
name: 5,8,11,14,17-eicosapentenoylcoa
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790

metaR NAtx
name: sodium transport via diffusion (perioxisome)
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true

metaR CYTDt
type: Reaction
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
name: cytidine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_c61676de_a141_403f_a85d_a062f5399adf
is encoded by: hsa:160851
is: SBO:0000252
type: Species
initial concentration: NaN
name: DGKH
constant: false
initial amount: NaN
is: A8K0I1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_2dda20e6_7b88_4ea8_9892_e013f3a73deb
has only substance units: false
is: SBO:0000252
is: Q9H845
type: Species
initial concentration: NaN
is encoded by: hsa:28976
initial amount: NaN
boundary condition: true
constant: false
name: ACAD9

metaM CE2917 e
type: Species
boundary condition: false
initial concentration: 1.0
is: C01936
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C69H114N23O16S CHARGE: 3 INCHI: InChI=1/C69H111N23O16S/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79)/p+3/t42-,43-,44-,45+,46-,47+,48+,49+,50-,51+,52+,53-/m1/s1 EHMN_ABBREVIATION: CE2917
name: apelin-13
constant: false
initial amount: NaN

metaR r2420
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110043#

metaR RE0583C
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0583
reversible: true
kinetic law: MODEL1310110043#

metaM ksi deg2 l
initial concentration: 1.0
is: HMDB00573
name: keratan sulfate I, degradation product 2
is: CHEBI:30825
constant: false
is: SBO:0000247
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR GPIAT
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000269
name: glucosaminylphosphatidyl inositol acetyltransferase
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD

metaM hs deg11 l
is: SBO:0000247
is: CHEBI:57737
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
initial concentration: 1.0
name: heparan sulfate, degradation product 11
constant: false
is: HMDB00868
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_03849c68_ab28_45aa_9557_4ff56ec151b2
boundary condition: true
is: SBO:0000252
name: SLC26A1
is encoded by: hsa:10861
is: Q9H2B4
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_6b482917_47d2_4f6a_a7b9_354dc926c0eb
name: COX4I2
initial concentration: NaN
constant: false
is encoded by: hsa:84701
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: Q96KJ9
is: SBO:0000252

metaM ksii core4 pre1 g
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 1
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:28067

metaR SCPx
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: peroxisomal thiolase 2
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000269

metaR RE3627M
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: RE3627

http://identifiers.org/biomodels.db/MODEL1310110043#_f117b6dc_7201_4549_ade4_c10bf9509aee
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000297
is encoded by: hsa:518
has only substance units: false
initial concentration: NaN
has part: P48201
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_86cc79c3_421f_425e_bde5_fb2da37c37b2
constant: false
initial concentration: NaN
name: ACADL
is encoded by: hsa:33
has only substance units: false
is: P28330
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM pyr x
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
is: CHEBI:15361
constant: false
boundary condition: false
has only substance units: false
name: pyruvate
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
initial concentration: 1.0
is: C00022
is: HMDB00243

metaM eicostetcoa m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: C16164
name: eicosatetranoyl coenzyme A
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR S6T7g
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
fast: false
is described by: ECO:0000000

metaM ksii core4 pre7 g
notes: FORMULA: C75H121N6O56SX CHARGE: -2
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 7
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
type: Species
is: C00130

metaR OCCOAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
product: MODEL1310110043#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000

metaM 44mzym r
name: 14-demethyllanosterol
boundary condition: false
has only substance units: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:18364
is: HMDB01286
is: SBO:0000247

metaM HC02179 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
constant: false
name: 20-hydroxy-arachidonate
has only substance units: false
type: Species

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_79ef53dc_de7e_4148_b584_59652285faae
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: B7Z6S9
is encoded by: hsa:2629
initial amount: NaN
constant: false
name: GBA
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_5da91fe2_eb83_4dd2_b5ea_a89d150f58b3
initial amount: NaN
name: AACS
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:65985
is: Q86V21
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_38a12591_994c_47fb_b1bc_47f3cb7465f0
name: SLCO3A1
initial amount: NaN
type: Species
is: Q9UIG8
initial concentration: NaN
constant: false
is encoded by: hsa:28232
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR GGH 6THFe
reactant: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6THF), extracellular
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110043#

metaM dd2coa c
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false

metaM 5HPET r
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 5(S)-HPETE(1-)
is: HMDB01193
is: CHEBI:57450

metaR GCC2cm
fast: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR CYTK4n
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,GTP),nuclear
kinetic law: MODEL1310110043#
reversible: true

metaR r0281
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000176
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/5.3.1.6
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110043#

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8298d1a7_ea26_480b_bd03_921214fe8292
is encoded by: hsa:4700
has part: Q6IB80
has part: P17568
is encoded by: hsa:126328
has part: P03905
is encoded by: hsa:4712
has part: O00217
has part: O95299
is encoded by: hsa:4702
has part: B7Z792
is encoded by: hsa:4728
is encoded by: hsa:4714
is encoded by: hsa:4707
is: SBO:0000297
has part: Q9Y6M9
is encoded by: hsa:51079
has part: P28331
has part: H7C5B8
has part: Q16795
is encoded by: hsa:4726
is encoded by: hsa:4704
is encoded by: hsa:4719
is encoded by: hsa:4696
is encoded by: hsa:55967
is encoded by: hsa:4716
has part: A8K761
has part: Q549M5
type: Species
has part: O75251
is encoded by: hsa:4538
is encoded by: hsa:4535
has part: O75489
initial concentration: NaN
has only substance units: false
has part: O95169
boundary condition: true
is encoded by: hsa:7991
is encoded by: hsa:4710
has part: Q6IBB5
is encoded by: hsa:4722
is encoded by: hsa:4701
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q13454
is encoded by: hsa:4731
has part: O43181
is encoded by: hsa:4708
initial amount: NaN
is encoded by: hsa:4724
is encoded by: hsa:4717
is encoded by: hsa:4694
is encoded by: hsa:4697
has part: P56556
has part: O95167
is encoded by: hsa:4729
has part: Q6IBA0
has part: F8VQS7
has part: O14561
is encoded by: hsa:374291
has part: B1AM93
is encoded by: hsa:4536
is encoded by: hsa:4705
has part: Q16718
has part: Q7GXZ1
is encoded by: hsa:4540
is encoded by: hsa:4698
has part: O43678
has part: O95139
has part: P19404
has part: O00483
has part: O95168
is encoded by: hsa:4539
has part: E5KNH5
is encoded by: hsa:4720
has part: P03897
has part: O75438
has part: Q6FG42
is encoded by: hsa:4706
is encoded by: hsa:4711
has part: Q7GXY9
has part: O43677

http://identifiers.org/biomodels.db/MODEL1310110043#_8aad5814_3a86_4668_8b85_6f64402e4347
name: NDUFA8
has only substance units: false
is: B1AM93
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4702
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_d43f714f_bd2b_4226_b2b4_6b1b9ce91329
has only substance units: false
type: Species
is encoded by: hsa:2936
initial amount: NaN
name: GSR
constant: false
is: P00390
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_c3703232_dbe0_4b61_a3a6_1e1c212ed91a
boundary condition: true
is encoded by: hsa:8611
type: Species
is: G3XA95
is: SBO:0000252
name: PPAP2A
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR ETFQO
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.5.1
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110043#
fast: false
reversible: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is: SBO:0000176
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110043#

metaM CE5868 e
constant: false
type: Species
is: HMDB02710
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
initial amount: NaN
boundary condition: false
is: CHEBI:27485
name: N-acetyl-seryl-aspartate

metaR PEPCKm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
name: Phosphoenolpyruvate carboxykinase (GTP)
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.32

http://identifiers.org/biomodels.db/MODEL1310110043#_4cad07c6_2308_42a4_8f8c_3b47d0546cfb
initial amount: NaN
is encoded by: hsa:6520
name: SLC3A2
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: P08195

metaR r0990
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true

metaR TETPENT6t
product: MODEL1310110043#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110043#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction

metaR H2Otg
name: H2O transport, Golgi apparatus
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR PIK3
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 3-kinase
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137

metaM ksi pre10 g
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 10
has only substance units: false
is: C00130
type: Species
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_bb82eddc_cd9c_449f_a423_6058ad561d80
initial amount: NaN
is: Q9NUB1
is encoded by: hsa:84532
has only substance units: false
constant: false
initial concentration: NaN
name: ACSS1
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_ea4c1d31_42cc_4da3_8005_2c047df58030
type: Species
is encoded by: hsa:115019
name: SLC26A9
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q7LBE3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7811fbe9_d703_48bb_8629_4128a1ed9abd
is: P17568
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4713
name: NDUFB7
type: Species
is: SBO:0000252

metaM tetpent6coa c
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
has only substance units: false
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
constant: false
is: C16172
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_7ff337ee_d443_453b_8529_e4e3875706c6
boundary condition: true
has only substance units: false
constant: false
name: SLC5A5
type: Species
initial amount: NaN
is: Q92911
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6528

metaR r0575
reversible: true
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#

metaR OMPDC
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
product: MODEL1310110043#
is described by: ECO:0000269
name: orotidine-5'-phosphate decarboxylase
is version of: http://identifiers.org/ec-code/2.4.2.10
is: SBO:0000176
reversible: false
reactant: MODEL1310110043#
fast: false
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f3c3e7db_dffb_41d7_90aa_9f6a98081e5b
is encoded by: hsa:2731
initial amount: NaN
has part: P48728
constant: false
type: Species
is encoded by: hsa:2653
has part: P23378
is encoded by: hsa:275
is: SBO:0000297
boundary condition: true
name: DLD:GCSH:GLDC:AMT
has part: P23434
initial concentration: NaN
has only substance units: false

metaM prpp e
initial concentration: 1.0
is: HMDB00280
is: CHEBI:58017
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
boundary condition: false

metaM dd2coa m
has only substance units: false
name: trans-dodec-2-enoyl-CoA(4-)
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: HMDB03712
initial concentration: 1.0
boundary condition: false

metaR r2080
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
reversible: true
is: SBO:0000185
modifier: MODEL1310110043#

metaR r1650
product: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

metaM c5dc e
is: HMDB13130
name: glutaryl carnitine
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H21NO6 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ced65da4_d921_49ab_9e7d_7a2dbd2525e6
initial concentration: NaN
is encoded by: hsa:AI091231
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI091231_1_c

metaR FAS140COA
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
fast: false
name: fatty-acyl-CoA synthase (n-C14:0CoA)
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_016aa964_2227_4a48_8a2a_14dfbb47f870
initial amount: NaN
is encoded by: hsa:6483
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q16842
type: Species
is: SBO:0000252
name: ST3GAL2
constant: false

metaR LDH L
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
name: L-lactate dehydrogenase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D

metaR DM Ser Thr ly
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaR GALSIDEtl
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
type: Reaction
reversible: true
is described by: ECO:0000000

metaR PGLYCt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
name: phosphatidylglycerol transport
reactant: MODEL1310110043#
fast: false
reversible: true
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_53f750d6_cde1_497d_a697_995b2d7fc3fa
initial amount: NaN
is: O43511
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5172
name: SLC26A4

metaR OCD11CRNCACT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM 3hmbcoa m
is: SBO:0000247
is: HMDB01356
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
boundary condition: false
type: Species
is: CHEBI:57312
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_f6316db1_c130_4d77_92bd_9edbc4c4c952
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: B4GALT1
is: P15291
is: SBO:0000252
is encoded by: hsa:2683
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_02092231_fcba_4cf7_a70b_2a299736303d
type: Species
is: SBO:0000252
name: SLC6A5
is encoded by: hsa:9152
is: Q9Y345
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM 3ddecdicoa x
name: 3,6-dodecadienoylcoa
type: Species
is: C05280
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB03952
has only substance units: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_1c422426_08f9_42e4_8f99_4efece5961d4
is encoded by: hsa:56623
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9NRR6
constant: false
name: INPP5E
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_ce05bb6e_160c_4594_b1d2_330d46ce79dd
name: ACADM
constant: false
is encoded by: hsa:34
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P11310

metaM 3snpyr m
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
initial amount: NaN
is: HMDB02332
type: Species
name: 3-Sulfinopyruvate
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:1665
initial concentration: 1.0
is: SBO:0000247

metaM dhcholestanate m
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00359
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577

http://identifiers.org/biomodels.db/MODEL1310110043#_a7f88292_e53d_4870_abc5_7abf23b32f18
is: O76074
boundary condition: true
type: Species
name: PDE5A
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:8654
is: SBO:0000252

metaM prpp c
initial concentration: 1.0
is: C00119
is: HMDB00280
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 5-Phospho-alpha-D-ribose 1-diphosphate

metaR ADPCOAPTE
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR PI4PLC
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000269
product: MODEL1310110043#

metaR ME1m
reversible: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110043#
name: malic enzyme (NAD), mitochondrial
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.38
kinetic law: MODEL1310110043#

metaM ksi deg13 l
is: SBO:0000247
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
is: HMDB00812
is: CHEBI:16953
name: keratan sulfate I, degradation product 13
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaM c5dc c
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB13130
type: Species
boundary condition: false
notes: FORMULA: C12H21NO6 CHARGE: 0
name: glutaryl carnitine
initial amount: NaN
is: SBO:0000247

metaR AG13T10g
type: Reaction
reversible: false
product: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110043#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM melatn c
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16796
name: melatonin
is: HMDB01389
initial amount: NaN
type: Species
is: SBO:0000247

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR CHSTEROLt3
fast: false
product: MODEL1310110043#
name: cholesterol intracellular transport
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true

metaR FACOAL181i
reversible: false
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
name: C181 fatty acid activation
modifier: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110043#

metaM pro D e
initial amount: NaN
is: CHEBI:16313
name: D-proline
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB03411
boundary condition: false
type: Species
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

metaM dmpp x
is: CHEBI:57623
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01120
name: prenyl diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110043#_cb1b33ef_6c90_42ed_a751_57bfdd3c9341
is: SBO:0000252
boundary condition: true
name: PCYT2
is: F5H8B1
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5833
initial amount: NaN
has only substance units: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR HEX4
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: hexokinase (D-mannose:ATP)
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975

metaR FAOXC164C163x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_20790faa_0075_4006_833d_a901abcbfbf5
is encoded by: hsa:9487
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: PIGL
initial concentration: NaN
is: Q9Y2B2
initial amount: NaN
has only substance units: false

metaR CHSTEROLt2
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
fast: false
name: cholesterol intracellular transport

metaR r0994
reversible: true
reactant: MODEL1310110043#
name: Facilitated diffusion
product: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR FAOXC162C162OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM pail hs c
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57880

http://identifiers.org/biomodels.db/MODEL1310110043#_39754fcd_3ec1_4810_8c24_c058bc7d42b3
has only substance units: false
boundary condition: true
is encoded by: hsa:112
initial concentration: NaN
is: O43306
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: ADCY6

metaR r1653
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR PAFS
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES:NJ
fast: false
type: Reaction
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
name: alkyl glycerol phosphocholine acetyl transferase
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176

metaM prostgd2 e
type: Species
is: HMDB01403
initial amount: NaN
is: SBO:0000247
name: prostaglandin D2(1-)
constant: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
has only substance units: false
initial concentration: 1.0

metaM caro c
boundary condition: false
is: HMDB00561
has only substance units: false
initial amount: NaN
is: CHEBI:17579
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C40H56 CHARGE: 0 INCHI: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ EHMN_ABBREVIATION: C02094
type: Species
name: beta-carotene

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.3.3.2
modifier: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
fast: false
reversible: true
type: Reaction

metaR CHSTEROLt1
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
reversible: true
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110043#
is: SBO:0000185

metaR SO4HCOtex
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: sulfate transport via bicarbonate countertransport
is described by: ECO:0000304
modifier: MODEL1310110043#
reversible: false
is: SBO:0000185
fast: false

metaM hs deg6 l
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
initial concentration: 1.0
name: heparan sulfate, degradation product 6
has only substance units: false
constant: false
is: HMDB01352
type: Species
is: CHEBI:17180
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR r0995
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110043#

metaM hco3 m
boundary condition: false
constant: false
is: HMDB00595
is: C00288
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17544
name: Bicarbonate
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM ahdt e
initial amount: NaN
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
has only substance units: false
constant: false
is: HMDB00980
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58462
type: Species
boundary condition: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895

metaR r1654
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_2e536cc9_e3df_4f3f_a518_f89445b95d61
name: GALNT11
type: Species
is: B3KWF4
is encoded by: hsa:63917
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR GLYLEUHYDROc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Glycylleucine in the small intestine for cellular uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7e75d8a1_8c50_44df_8a81_d3f8d6873d5a
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5313
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P30613
has only substance units: false
name: PKLR

http://identifiers.org/biomodels.db/MODEL1310110043#_e962360a_83be_44a9_8170_d14b6c24406d
name: _AI935189_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI935189
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR C6COAt
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaR r1651
is described by: ECO:0000000
modifier: MODEL1310110043#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false

metaR SEBCOACROT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR G14T7g
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

metaM HC01361 e
is: SBO:0000247
constant: false
type: Species
is: CHEBI:17001
boundary condition: false
name: Dihydroneopterin
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
initial concentration: 1.0

metaR RE2972M
type: Reaction
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reversible: true
name: RE2972
modifier: MODEL1310110043#

metaM sprm e
initial concentration: 1.0
name: spermine(4+)
is: HMDB01256
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
has only substance units: false
is: CHEBI:45725
constant: false

metaM 3hexdtetcoa m
constant: false
is: SBO:0000247
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB02288

metaR FAOXC16C14m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7883907f_0249_4d7c_957d_3fa2d2f99857
is encoded by: hsa:80201
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: B3KT70
name: HKDC1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_c07240eb_0507_452a_affb_258930c77459
is: P36957
is encoded by: hsa:1743
constant: false
is: SBO:0000252
initial concentration: NaN
name: DLST
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_80f29010_a63f_4088_8d64_a06224beb46c
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:9415
type: Species
is: O95864
name: FADS2
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM prostgd2 c
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01403
name: prostaglandin D2(1-)
initial amount: NaN
type: Species
is: CHEBI:57406
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696

metaR 4MOPt2im
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR HEX7
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000304
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4

http://identifiers.org/biomodels.db/MODEL1310110043#_a607a83e_745c_482c_8323_a2f63e3adea3
name: DCTD
initial amount: NaN
boundary condition: true
is: P32321
is: SBO:0000252
is encoded by: hsa:1635
has only substance units: false
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_36f21cdb_b0ed_484d_8da1_1f7e14023091
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8942
constant: false
type: Species
name: KYNU
initial concentration: NaN
is: Q16719
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_af6925f0_d0ec_4fb5_baa0_da8ec1df52c7
has only substance units: false
is encoded by: hsa:2530
boundary condition: true
name: FUT8
initial amount: NaN
is: G3V5N0
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaR BILDGLCURtr
product: MODEL1310110043#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
name: glucuronidated compound transport
is: SBO:0000185
is described by: ECO:0000000

metaR r1652
reversible: true
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110043#

metaR AHC
is version of: http://identifiers.org/ec-code/3.3.1.1
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110043#
is: SBO:0000176
name: adenosylhomocysteinase
kinetic law: MODEL1310110043#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b9343d29_1d98_4eb4_ae55_639d3be1016c
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4830
type: Species
name: NME1
is: P15531
initial amount: NaN

metaR NAGAlby
reactant: MODEL1310110043#
name: N-acetylgalactosaminidase, beta-
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
type: Reaction
product: MODEL1310110043#
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM gsn e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00133
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
type: Species
name: Guanosine
is: C00387
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16750

metaR RE2659R
reversible: true
is described by: ECO:0000000
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110043#
name: RE2659
is: SBO:0000176

metaR r1668
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
name: Y+LAT2 Utilized transport
modifier: MODEL1310110043#
reactant: MODEL1310110043#

metaR r2098
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110043#
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#

metaM 3mob e
name: 3-methyl-2-oxobutanoate
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:11851
is: SBO:0000247
initial concentration: 1.0
is: HMDB00019
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8f3d3e9e_b575_497f_a9fa_d0bf1ccf88ec
name: SLC35A1
constant: false
is: P78382
is encoded by: hsa:10559
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR G5SADrm
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
reactant: MODEL1310110043#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial

metaR r1667
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: true
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110043#
is: SBO:0000185

metaR r2097
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
reversible: true
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_c1d930ec_d1bb_4709_9e90_d26ddf46c664
initial amount: NaN
is: A6NFM2
is encoded by: hsa:5831
is: SBO:0000252
type: Species
has only substance units: false
name: PYCR1
boundary condition: true
initial concentration: NaN
constant: false

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_51ef197a_5c14_4509_9bb1_0e4d97520254
is encoded by: hsa:175
is: SBO:0000252
boundary condition: true
constant: false
name: AGA
initial concentration: NaN
initial amount: NaN
is: P20933
type: Species
has only substance units: false

metaM pro D c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
initial amount: NaN
type: Species
is: CHEBI:16313
is: SBO:0000247
boundary condition: false
name: D-proline

http://identifiers.org/biomodels.db/MODEL1310110043#_002d49cc_619e_4ee5_9ce5_c8461dd3e0ca
type: Species
is: SBO:0000252
is: E7EQF2
has only substance units: false
name: CROT
constant: false
initial concentration: NaN
is encoded by: hsa:54677
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_4d2bb04e_e5e2_46e3_be81_0e2a9c2a341e
boundary condition: true
type: Species
name: _BF195998_1_x
has only substance units: false
is: SBO:0000252
is encoded by: hsa:BF195998
initial concentration: NaN
initial amount: NaN
constant: false

metaM tethex3 c
type: Species
constant: false
initial concentration: 1.0
is: HMDB02007
boundary condition: false
name: tetracosahexaenoic acid, n-3
has only substance units: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial amount: NaN
is: SBO:0000247

metaR FAOXC161C141x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaM oh1 c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01039
name: hydroxide ion
constant: false
is: C01328
notes: FORMULA: HO CHARGE: -1
type: Species
boundary condition: false
has only substance units: false

metaM gsn c
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
name: Guanosine
initial amount: NaN
type: Species
is: HMDB00133
is: C00387
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaM dopasf c
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:37946
type: Species
boundary condition: false
is: SBO:0000247
name: dopamine 3-O-sulfate
has only substance units: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275

metaM gmp c
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
boundary condition: false
name: GMP
is: SBO:0000247
is: C00144
constant: false
is: HMDB01397
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58115

http://identifiers.org/biomodels.db/MODEL1310110043#_7f1cb17c_7e4c_41db_ac45_119d2141a4d5
initial amount: NaN
type: Species
is: SBO:0000297
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51227
constant: false
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r0130
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#

metaM ksi deg26 l
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58343
is: HMDB00061
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 26
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial amount: NaN

metaM prgnlone r
is: CHEBI:16581
initial concentration: 1.0
boundary condition: false
name: pregnenolone
constant: false
is: SBO:0000247
type: Species
is: HMDB00253
has only substance units: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_182292f5_47db_4807_9bcb_1f209fac6967
boundary condition: true
constant: false
has only substance units: false
name: SHMT2
is: B4DJQ3
initial amount: NaN
is encoded by: hsa:6472
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_c9107c79_5c50_48d1_a564_c59408f83034
constant: false
boundary condition: true
is encoded by: hsa:AA526438
type: Species
initial concentration: NaN
name: _AA526438_1_c
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_55a05bdc_90ca_48c3_9285_3f5d338dbf56
has only substance units: false
name: SLC2A10
is encoded by: hsa:81031
is: SBO:0000252
initial amount: NaN
constant: false
is: O95528
boundary condition: true
type: Species
initial concentration: NaN

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR 4NPHte
reversible: true
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: xenobiotic transport
type: Reaction
is: SBO:0000185

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR r1669
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
reversible: true
name: Y+LAT2 Utilized transport

metaR r2419
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false

metaM gua e
type: Species
constant: false
is: HMDB00132
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
name: guanine
is: CHEBI:16235
has only substance units: false

metaR r2099
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
reversible: true
modifier: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NAt
is: SBO:0000185
kinetic law: MODEL1310110043#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
reactant: MODEL1310110043#
reversible: true
name: sodium transport (uniport)

metaR RETI2
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
fast: false
product: MODEL1310110043#
name: retinol isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
is: SBO:0000176

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM 3hodcoa m
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR FAOXC225C226m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR S4TASE2ly
reactant: MODEL1310110043#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.12
kinetic law: MODEL1310110043#

metaR RE3243R
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
modifier: MODEL1310110043#
is described by: ECO:0000000
name: RE3243

metaM dopasf e
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial concentration: 1.0
is: CHEBI:37946
type: Species
constant: false
has only substance units: false
name: dopamine 3-O-sulfate
is: SBO:0000247
initial amount: NaN
is: HMDB06275

metaR TETHEX3COAtx
name: fatty acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR FACOAL1813
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
product: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
reversible: true
fast: false

metaM tethex3 e
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02007
name: tetracosahexaenoic acid, n-3

metaR AMPTASECGe
name: alanyl aminopeptidase (cys-gly) (e)
notes: GENE_ASSOCIATION: (290.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.2 Confidence Level: 4 AUTHORS: PMID:6126478 NOTES:SAB. rat lumen renal proximal tubule preparation cysteinylglycine metabolism measured due to aminopeptidase M (=N); the annotation in BiGG of strong biochemical evidence in a textbook could not be found in the Google Books version search of this book; intensively sought for human metabolism; human metabolism is likely though not proven directly
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.11.2
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_08d6746d_93b3_4c14_bd66_6b7288f54499
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8654
initial amount: NaN
name: PDE5A
boundary condition: true
type: Species

metaR MAL Lte
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
type: Reaction
name: Transport of L-malate

http://identifiers.org/biomodels.db/MODEL1310110043#_75f16787_82da_474e_9e8d_925f2eeaa9fe
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P00568
is encoded by: hsa:203
initial concentration: NaN
constant: false
name: AK1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_c76d914c_00f1_46fc_b467_f98c53d92e0c
initial amount: NaN
name: PLCG1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5335
is: P19174
has only substance units: false
constant: false
type: Species

metaR TETPENT6COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: fatty acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#
fast: false

metaR ALCD21 L
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.99.24
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
name: alcohol dehydrogenase (L-1,2-propanediol)
fast: false
product: MODEL1310110043#
is described by: ECO:0000304

metaR LYSOXp
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: L-lysine oxidase, peroxisomal
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110043#

metaR r2094
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ea732e3a_e8ba_4de7_89f4_d325d462f22a
has part: P00326
is: SBO:0000297
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: ADH1A:ADH1C
type: Species
boundary condition: true
is encoded by: hsa:126

metaM gua c
is: C00242
boundary condition: false
initial amount: NaN
is: HMDB00132
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: CHEBI:16235
name: Guanine
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_06f93920_6fe4_43a2_b0d4_531136155c0d
has only substance units: false
name: ALPL
initial amount: NaN
type: Species
boundary condition: true
is: B7Z4Y6
constant: false
is: SBO:0000252
is encoded by: hsa:249
initial concentration: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_057eceda_7c70_438f_9f88_0c949b2a00e1
initial amount: NaN
type: Species
is: SBO:0000297
is encoded by: hsa:55350
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: VNN3:VNN2:VNN1

metaR O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: o2 transport (diffusion)
fast: false
product: MODEL1310110043#

metaM CE1925 e
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
type: Species
initial amount: NaN
name: 3'-carboxy-alpha-chromanol
initial concentration: 1.0
constant: false
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925

metaR ASPTAm
reversible: true
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110043#
name: aspartate transaminase

http://identifiers.org/biomodels.db/MODEL1310110043#_51588f92_7454_4df2_a3e9_97b2b3346a3b
is: SBO:0000252
initial amount: NaN
is: Q9NUB1
constant: false
initial concentration: NaN
name: ACSS1
boundary condition: true
has only substance units: false
is encoded by: hsa:84532
type: Species

metaM 5HPET c
is: HMDB01193
initial concentration: 1.0
boundary condition: false
constant: false
name: 5(S)-HPETE(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: CHEBI:57450
type: Species
is: SBO:0000247
has only substance units: false

metaR AG13T5g
modifier: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
fast: false

metaR RE1523M
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
name: RE1523
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
type: Reaction

metaR r2093
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true

metaM pydam c
type: Species
is: CHEBI:57761
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00534
boundary condition: false
name: Pyridoxamine
constant: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: HMDB01431

metaR FAOXC204184m
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_e8424c76_f8eb_4e5e_8d4a_1ca892261912
boundary condition: true
is encoded by: hsa:482
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ATP1B2
is: P14415
type: Species

metaR SUCOAS1m
product: MODEL1310110043#
is described by: ECO:0000000
name: Succinate--CoA ligase (GDP-forming)
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF

http://identifiers.org/biomodels.db/MODEL1310110043#_e93cda23_6d23_4e93_9b93_104b77e7641a
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:115584
name: SLC5A11
initial amount: NaN
has only substance units: false
is: Q8WWX8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_9fc2edbf_a238_474f_9dc5_a498411da0d1
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:80270
name: HSD3B7
constant: false
initial amount: NaN
boundary condition: true
is: Q9H2F3

metaR S6T14g
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110043#

metaM HC01115 c
initial amount: NaN
is: CHEBI:29025
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
type: Species
boundary condition: false
name: NeuNGc
is: SBO:0000247
constant: false

metaR PLA2 2e
kinetic law: MODEL1310110043#
name: phospholipase A2
type: Reaction
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_782e92e7_ccaa_44d2_b098_6c270b7ae09d
is: Q6PII5
initial concentration: NaN
is encoded by: hsa:84264
constant: false
boundary condition: true
name: HAGHL
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b327a4bc_878a_40fc_8239_f31011b90708
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q4FEB3
initial concentration: NaN
boundary condition: true
name: CMA1
type: Species
is encoded by: hsa:1215

metaR SPMS
is version of: http://identifiers.org/ec-code/2.5.1.16
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
type: Reaction
name: spermidine synthase
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_03da322b_4998_4fdf_9a81_a21a35cb3297
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PLA2G2A
constant: false
is encoded by: hsa:5320
boundary condition: true
type: Species
is: P14555
initial amount: NaN

metaR C4STMO1r
type: Reaction
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.14.13.72
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#

metaR r2096
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
fast: false

metaR ME2m
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.38
is version of: http://identifiers.org/ec-code/1.1.1.40
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
fast: false
reversible: false
name: malic enzyme (NADP), mitochondrial
product: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR FACOAL1812
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
modifier: MODEL1310110043#
name: fatty-acid--CoA ligase
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_3ae1ec47_37e7_434a_975a_f96fc38113dc
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:4758
name: NEU1
constant: false
is: SBO:0000252
has only substance units: false
is: Q99519

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_e6975fd8_8c9e_4f02_829e_4e0bc93f908f
initial concentration: NaN
initial amount: NaN
name: PDE9A
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5152

metaM hxcoa x
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00705
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4

metaM 3mob m
is: HMDB00019
has only substance units: false
type: Species
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851

metaM cs c deg2 l
has only substance units: false
is: CHEBI:15748
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
type: Species
initial concentration: 1.0

metaR FAOXC163x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_6515104e_fed0_4409_bb65_d13849bd9cc0
has only substance units: false
is encoded by: hsa:443
constant: false
type: Species
name: ASPA
initial concentration: NaN
is: SBO:0000252
is: Q6FH48
initial amount: NaN
boundary condition: true

metaM vacccoa c
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
is: SBO:0000247
name: vaccenyl coenzyme A
type: Species
is: HMDB06521
boundary condition: false
initial amount: NaN

metaM pydam e
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
has only substance units: false
constant: false
is: CHEBI:57761
initial amount: NaN
initial concentration: 1.0
is: HMDB01431
is: C00534
boundary condition: false
type: Species
is: SBO:0000247
name: Pyridoxamine

metaR FAOXC5C5DCc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_792e77c3_1f8a_49ca_a210_33c0728617f8
is: SBO:0000252
is encoded by: hsa:8503
name: PIK3R3
type: Species
has only substance units: false
boundary condition: true
is: Q92569
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR r2095
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#

metaR FAOXC225C226x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_06e01b1d_4205_447f_b700_1491d34d969e
name: DEGS1
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8560
is: O15121
constant: false

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
is: HMDB00064
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
name: creatine
has only substance units: false
initial concentration: 1.0
constant: false

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:32984
type: Species
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine

metaR FADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
name: FAD transporter, peroxisomal
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_05e33953_5fc3_4ce3_8609_617e636646b1
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI769281
name: _AI769281_1_e
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_883cfe97_026c_4d8c_8cb9_b620f0664e8a
has only substance units: false
is encoded by: hsa:271
initial amount: NaN
constant: false
name: AMPD2
type: Species
is: B2RB47
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_8ecb9347_6f26_49fd_8c30_ef935208f888
initial concentration: NaN
boundary condition: true
type: Species
is: Q13370
name: PDE3B
constant: false
initial amount: NaN
is encoded by: hsa:5140
is: SBO:0000252
has only substance units: false

metaM tmndnc c
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/446284
constant: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB01999

metaR CSNATer
is: SBO:0000176
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.7
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
type: Reaction
kinetic law: MODEL1310110043#
name: carnitine O-acetyltransferase, endolasmic reticulum
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_3544e173_09a5_4122_b07a_e89e2bdae5bb
is encoded by: hsa:26002
constant: false
is: Q6UVY6
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: MOXD1
boundary condition: true
initial concentration: NaN

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM bildglcur r
initial amount: NaN
has only substance units: false
constant: false
is: HMDB03325
boundary condition: false
is: CHEBI:58471
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_d2a03628_3550_40ae_9005_78852a4d3439
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q6GTM5
name: SC5DL
is encoded by: hsa:6309
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_fab7aeef_1304_4b1e_af05_8896ddc2d2a3
boundary condition: true
name: GSR
type: Species
is: P00390
has only substance units: false
is encoded by: hsa:2936
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8566354e_d269_42e5_834d_22332eef43e0
is: SBO:0000252
initial amount: NaN
name: SLC22A5
constant: false
initial concentration: NaN
is encoded by: hsa:6584
type: Species
has only substance units: false
boundary condition: true
is: O76082

metaR FAOXC101C8m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR FUT15g
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
fast: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110043#

metaR CYANt
reversible: true
name: Cyanide transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ca34b60f_d257_4222_b7bd_7d17f8055389
is encoded by: hsa:AV717590
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AV717590_1_c
initial concentration: NaN
type: Species

metaM tymsf c
name: Tyramine O-sulfate
is: HMDB06409
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaR 5MTHFt2le
reversible: true
name: 5-methyltetrahydrofolate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110043#
fast: false
type: Reaction
product: MODEL1310110043#

metaR G14T17g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_fdff4749_2fe1_4c42_b27a_3a5507ef99a0
has only substance units: false
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:517
boundary condition: true
type: Species
is encoded by: hsa:9551
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
has part: F8W7V3

metaR GHMT2rm
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
type: Reaction
name: glycine hydroxymethyltransferase, reversible, mitochondrial
modifier: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_593af6bb_a482_4644_b76d_e0c3b665cbe9
type: Species
initial amount: NaN
is: SBO:0000252
name: IK
is: Q13123
constant: false
is encoded by: hsa:3550
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_253dba0a_530b_43e6_b8bb_ad1f5bb8ff07
is: SBO:0000252
type: Species
name: NDUFS6
is encoded by: hsa:4726
has only substance units: false
constant: false
boundary condition: true
is: Q6IBC4
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_2076a6dd_4fda_49a8_8c93_7f1e6e9b594c
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:1593
is: Q02318
boundary condition: true
name: CYP27A1

metaR HSD3A2r
is: SBO:0000176
reactant: MODEL1310110043#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
reversible: true

metaR FAOXC161C141m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR CYTK5n
is described by: ECO:0000269
modifier: MODEL1310110043#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110043#
product: MODEL1310110043#

metaM dlnlcg e
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02925
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
type: Species
initial amount: NaN
is: SBO:0000247

metaM creat e
has only substance units: false
is: CHEBI:16919
is: HMDB00064
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: creatine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_41ef6034_ca67_4e44_8e38_412bc4f35e86
name: MVD
type: Species
has only substance units: false
is: P53602
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4597
boundary condition: true
constant: false
initial concentration: NaN

metaR r0283
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.6
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
name: L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11

http://identifiers.org/biomodels.db/MODEL1310110043#_6ffbf4fa_013c_48ac_9113_af0d3f19025c
is: Q542Y6
is encoded by: hsa:81579
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PLA2G12A
boundary condition: true
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_e2098baf_1044_4be3_a834_0f8259d87952
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: PDE9A
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110043#_3b712870_ac03_4015_b8b4_de5c6f12ba85
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3284
constant: false
boundary condition: true
initial amount: NaN
name: HSD3B2
initial concentration: NaN
type: Species
is: P26439

metaM ksi deg33 l
type: Species
boundary condition: false
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 33
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C76H125N5O62S2 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110043#_18c0bead_0d66_48a3_b1b7_1aa7fcc409cd
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: RFK
is encoded by: hsa:55312
is: B2RDZ2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_f97f6c49_fde8_4357_97da_643da2130480
type: Species
constant: false
boundary condition: true
name: GCNT4
is encoded by: hsa:51301
is: SBO:0000252
is: Q9P109
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_0a138fbb_3723_4c3c_ba83_3ea225cbeea2
has only substance units: false
is encoded by: hsa:11041
initial amount: NaN
boundary condition: true
name: B3GNT1
initial concentration: NaN
is: O43505
is: SBO:0000252
constant: false
type: Species

metaR BDHm
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is described by: ECO:0000269
product: MODEL1310110043#
is: SBO:0000176

metaM tymsf e
name: Tyramine O-sulfate
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB06409
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)

http://identifiers.org/biomodels.db/MODEL1310110043#_b3fd3808_82d7_49aa_b9c8_62ee49b6b4b0
is: P23921
name: RRM1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6240
is: SBO:0000252
constant: false

metaM so3 c
type: Species
constant: false
is: HMDB00240
has only substance units: false
is: C00094
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:17137
is: SBO:0000247
name: Sulfite
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

metaR EICOSTETCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
name: transport into the mitochondria (carnitine)
reversible: false
fast: false

metaR CYSSERNaEx
reversible: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)

metaM prist c
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00795
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:51340
name: pristanic acid

http://identifiers.org/biomodels.db/MODEL1310110043#_26cd008c_2302_4a4c_a834_f3085cab3c66
boundary condition: true
is: SBO:0000252
name: SLC25A13
constant: false
type: Species
is encoded by: hsa:10165
has only substance units: false
initial amount: NaN
is: Q9UJS0
initial concentration: NaN

metaR r0139
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM etfrd m
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00145
initial amount: NaN
constant: false
notes: FORMULA: RH2 CHARGE: 0
is: CHEBI:17263
initial concentration: 1.0
name: Electron transfer flavoprotein reduced
has only substance units: false

metaM cs e deg3 l
is: CHEBI:15748
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C37H53NO44S4 CHARGE: -6
has only substance units: false
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110043#_cfb0cb22_3ded_4849_ba02_e206ebfef68a
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:211
name: ALAS1
constant: false
initial concentration: NaN
has only substance units: false
is: P13196

metaR CYTDn
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.4.5
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000254
reversible: false
name: cytidine deaminase, nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_5b3eedad_747c_44ac_942b_b5dae8aa8100
is: Q15758
is encoded by: hsa:6510
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: SLC1A5

metaR ALCD21 D
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000304
reactant: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
name: alcohol dehydrogenase (D-1,2-propanediol)

metaR SPHK21c
reactant: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.91
fast: false
reversible: false
name: sphingosine kinase 2
is: SBO:0000176

metaM 4abutn m
has only substance units: false
is: HMDB01080
is: SBO:0000247
boundary condition: false
type: Species
name: 4-ammoniobutanal
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
constant: false
is: CHEBI:58264

metaM dlnlcg c
initial concentration: 1.0
constant: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
is: HMDB02925
is: CHEBI:53486
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_880eefee_a04c_4a06_b7b9_b54e644cb77c
name: ATP1B1
initial amount: NaN
is encoded by: hsa:481
is: A3KLL5
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR C10DCCACT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR KYNAKGAT
is: SBO:0000176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000269
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
fast: false

metaM HC02121 c
constant: false
type: Species
is: CHEBI:58758
initial concentration: 1.0
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
boundary condition: false
is: SBO:0000247

metaM galthcrm hs g
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Gal-Gal-Gal-Glc-Cer
constant: false
is: CHEBI:26174
initial amount: NaN
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0

metaM hs deg15 l
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
initial concentration: 1.0
constant: false
name: heparan sulfate, degradation product 15
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:16126
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_bad293de_64d2_4364_af48_968cc0f341b5
is: SBO:0000252
is: O60547
initial amount: NaN
is encoded by: hsa:2762
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: GMDS

metaR FAOXC16DCr
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_0543f8b9_4ba1_49f4_833d_ee948d4d3f13
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:3939
has only substance units: false
name: LDHA
type: Species
is: P00338

metaM 3hodcoa c
has only substance units: false
initial amount: NaN
is: HMDB13336
is: SBO:0000247
name: (S)-3-Hydroxyoctadecanoyl-CoA
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H66N7O18P3S CHARGE: -4

metaR RE0938E
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/3.4.17.23
notes: GENE_ASSOCIATION: (59272.1) SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 0 AUTHORS: PMID:10969042,PMID:11384769,PMID:11815627 NOTES:
is: SBO:0000176
name: RE0938
type: Reaction
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR PYDXNK
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: pyridoxine kinase
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.35
reactant: MODEL1310110043#
reversible: false

metaR DM atp c
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110043#
name: DM_atp(c)
is: SBO:0000176

metaR DNDPt25m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reversible: false
name: dTDP transport via dCDP antiport
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
fast: false

metaR r0871
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#

metaR FAOXC14C14OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaM tmndnc e
is: http://identifiers.org/pubchem.compound/446284
is: HMDB01999
constant: false
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
has only substance units: false
name: timnodonic acid C20:5, n-3
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaM 3mob c
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
initial concentration: 1.0
is: HMDB00019
boundary condition: false
constant: false
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM octdececoa c
name: octadecenoylcoa
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06351
constant: false

metaR r0870
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.4.13
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.72
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.3.4
reversible: true
fast: false
name: Facilitated diffusion
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110043#

metaR r0287
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110043#
type: Reaction

metaM c8dc c
type: Species
is: SBO:0000247
has only substance units: false
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
is: HMDB00791
initial amount: NaN
initial concentration: 1.0
is: C02838
constant: false

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_c57d0bae_b801_4bf2_b682_bb5411d812bb
initial amount: NaN
constant: false
name: NDUFC1
boundary condition: true
type: Species
is encoded by: hsa:4717
is: O43677
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR NACHEXA10ly
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110043#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false

metaM 3hexdtricoa m
is: HMDB02288
type: Species
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
name: 3,7,10-hexadecatrienoylcoa
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_86f85263_5f09_4333_bf6c_9ebbc4c284d9
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1376
type: Species
boundary condition: true
is: P23786
initial concentration: NaN
constant: false
initial amount: NaN
name: CPT2

metaR Uritn
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
type: Reaction
name: uridine transport in nucleus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110043#

metaM 3deccrn c
is: SBO:0000247
name: 3-hydroxydecanoylcarnitine
initial concentration: 1.0
is: HMDB00651
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H33NO5 CHARGE: 0

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR r1384
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
type: Reaction
name: Guanosine aminohydrolase EC:3.5.4.15
reversible: true
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#

metaM g3m8masn r
notes: FORMULA: C88H147N2O70X CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
boundary condition: false
is: C05873
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_b6f15767_45b5_4e99_91f2_1b4f2bb62483
name: _AA629629_1_m
constant: false
initial concentration: NaN
is encoded by: hsa:AA629629
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaM 3hanthrn c
has only substance units: false
type: Species
initial amount: NaN
name: 3-hydroxyanthranilate
constant: false
notes: FORMULA: C7H7NO3 CHARGE: 0 INCHI: InChI=1S/C7H7NO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,8H2,(H,10,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00464 EHMN_ABBREVIATION: C00632
is: HMDB01476
is: CHEBI:36559
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b1be4a15_5d6d_4211_a1cf_339a538987d5
initial concentration: NaN
is encoded by: hsa:2805
has only substance units: false
constant: false
name: GOT1
type: Species
boundary condition: true
is: SBO:0000252
is: P17174
initial amount: NaN

metaR r1512
reactant: MODEL1310110043#
reversible: false
name: Utilized transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false

metaM 5forthf c
is: SBO:0000247
is: HMDB01534
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57456
name: 5-Formiminotetrahydrofolate
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: C00664
constant: false
initial amount: NaN

metaR VD3
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
name: Vitamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110043#
type: Reaction
reversible: true
is described by: ECO:0000134

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM ctp c
constant: false
is: HMDB00082
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
is: C00063
name: CTP
has only substance units: false

metaR UMPK
reactant: MODEL1310110043#
product: MODEL1310110043#
name: UMP kinase
reversible: true
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM odecrn c
name: octadecenoyl carnitine
is: C00412
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57394
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: SBO:0000247
is: HMDB01114
constant: false
has only substance units: false

metaR FAOXC226C205m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM core6 l
initial amount: NaN
constant: false
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
boundary condition: false
type: Species
name: Core 6
has only substance units: false
is: SBO:0000247

metaM T antigen g
name: T antigen (core 1)
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:22783
notes: FORMULA: C14H24NO10X CHARGE: 0

metaM 3hibutcoa m
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
constant: false
is: HMDB01052
is: SBO:0000247
boundary condition: false
is: CHEBI:28259
name: (S)-3-Hydroxyisobutyryl-CoA
initial concentration: 1.0

metaR HSAT1ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000

metaM vacccoa m
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
type: Species
name: vaccenyl coenzyme A
is: HMDB06521
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_36f6efc2_21cb_400d_9d70_236a4e57b251
name: DOLPP1
is encoded by: hsa:57171
is: SBO:0000252
is: Q86YN1
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaM so3 m
is: HMDB00240
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
is: CHEBI:17137
name: hydrogensulfite
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_6c7a858f_beaa_4af4_893c_6e95196563f1
is: SBO:0000252
boundary condition: true
is: P38571
type: Species
is encoded by: hsa:3988
constant: false
name: LIPA
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR MANtg
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110043#
name: mannose efflux from Golgi apparatus
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_441aee86_358d_4372_839e_676123143237
is encoded by: hsa:478
is: SBO:0000297
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
has part: B7Z2T0
is encoded by: hsa:481
type: Species
has part: A3KLL5
name: ATP1A3:ATP1B1

metaR r1957
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false

metaR KSIt
name: keratan sulfate I transport, golgi to extracellular
fast: false
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110043#
reversible: false

metaR IDOAASE4ly
name: alpha-L-iduronidase, lysosomal
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_f783fbc8_5d46_4a32_a9b6_a3d112a83f50
is encoded by: hsa:10587
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: TXNRD2

metaR GLYLEUPEPT1tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_bb350f1a_de91_4c4d_930b_a158741639e1
constant: false
name: PLCD4
has only substance units: false
is: Q9BRC7
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:84812
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_be493ac8_1a44_46f2_b12d_5d9802d971a0
boundary condition: true
constant: false
initial concentration: NaN
name: ATP5E
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:514

metaM prpncoa m
constant: false
name: acryloyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307
boundary condition: false
type: Species
is: CHEBI:57367
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_2cf3b37f_a727_4c27_8419_b1f27ad5014d
type: Species
boundary condition: true
has part: Q99643
has part: P31040
is encoded by: hsa:6392
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6390
has part: O14521
is encoded by: hsa:6391
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6389
constant: false
has part: P21912
initial amount: NaN

metaR FAOXC81C61m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR r0410
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
fast: false
reversible: true

metaM ksii core2 pre8 g
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
constant: false
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: HMDB00175
boundary condition: false
initial concentration: 1.0
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110043#_36b7bab6_7540_450d_b164_16385ae85e14
has only substance units: false
boundary condition: true
constant: false
name: NDUFV1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4723
initial amount: NaN
is: E5KNH5

http://identifiers.org/biomodels.db/MODEL1310110043#_a6e2b70f_e7fd_4b9f_92fc_5eea92f7ee75
name: ALDH7A1
boundary condition: true
is: E7EPT3
constant: false
type: Species
is encoded by: hsa:501
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR GLRASE
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110043#
is described by: ECO:0000000
name: glucuronolactone reductase
reversible: true
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000176
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_ad572a72_66c3_4017_8076_6229fa012546
is: B7Z763
constant: false
has only substance units: false
type: Species
is encoded by: hsa:272
boundary condition: true
is: SBO:0000252
name: AMPD3
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_18eae2b0_c7c6_4091_bedd_ae5e9bcf7ec0
constant: false
name: PLCE1
boundary condition: true
is encoded by: hsa:51196
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9P212

metaM ksii core2 deg1 l
initial amount: NaN
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: HMDB00868
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57737
name: keratan sulfate II (core 2-linked), degradation product 1

metaR H2Otly
name: H2O transport, lysosomal
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110043#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8c8f4197_008c_483d_ace2_c7eb528ffca6
is encoded by: hsa:4166
constant: false
name: CHST6
has only substance units: false
type: Species
is: Q9GZX3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM ptdcacoa c
name: pentadecanoyl Coenzyme A
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06499
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1

metaM mthgxl c
initial amount: NaN
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
initial concentration: 1.0
is: HMDB01167
is: CHEBI:17158
has only substance units: false
name: methylglyoxal
type: Species
boundary condition: false
is: SBO:0000247

metaR ADK3m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reversible: true
name: adentylate kinase (GTP)
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110043#

metaM CE5788 e
is: CHEBI:27485
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
name: kinetensin 1-7
boundary condition: false
has only substance units: false
type: Species
is: HMDB02710
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM 4abutn c
constant: false
has only substance units: false
initial amount: NaN
name: 4-Aminobutanal
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
boundary condition: false
is: CHEBI:58264
is: C00555
type: Species
is: HMDB01080
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_4c2e2582_7df5_4534_a94f_126e7b07ecec
constant: false
is encoded by: hsa:22934
initial amount: NaN
name: RPIA
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: P49247

metaM prgnlone c
is: CHEBI:16581
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
constant: false
type: Species
name: pregnenolone
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00253
boundary condition: false
has only substance units: false

metaM camp c
constant: false
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
type: Species
is: SBO:0000247
name: 3',5'-cyclic AMP(1-)
boundary condition: false
is: HMDB00058
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58165

metaM pram c
constant: false
initial amount: NaN
has only substance units: false
is: C03090
name: 5-Phospho-beta-D-ribosylamine
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: CHEBI:58681
is: HMDB01128
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_199fb093_c98e_48b3_9ced_82af4af1841f
boundary condition: true
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
type: Species
is: SBO:0000297
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:7991
has only substance units: false

metaR FAS120COA
is described by: ECO:0000269
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
name: fatty-acyl-CoA synthase (n-C12:0CoA)
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD

metaM 1p3h5c m
constant: false
is: SBO:0000247
is: CHEBI:6151
is: HMDB01369
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaM hs deg7 l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: heparan sulfate, degradation product 7
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
has only substance units: false
initial amount: NaN
is: CHEBI:17180
type: Species
constant: false
is: HMDB01352

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM din e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00071
has only substance units: false
is: C05512
type: Species
name: Deoxyinosine
constant: false
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial amount: NaN

metaR ACGALtlg
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
product: MODEL1310110043#
reversible: true
name: N-acetyl-galactosamine intracellular transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
type: Reaction

metaM mescoa m
is: SBO:0000247
initial amount: NaN
is: CHEBI:27969
initial concentration: 1.0
has only substance units: false
is: C06028
type: Species
constant: false
boundary condition: false
name: Mesaconyl-CoA
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110043#_036abce9_91d4_4818_9f7a_ea4fe6b4a472
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:D87002
is: SBO:0000252
name: _D87002_1_e

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7a39b8a2_8801_493f_81bd_7b848c0c0e71
has only substance units: false
is encoded by: hsa:AA177072
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AA177072_1_c
boundary condition: true

metaM C04849 e
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM 4abutn e
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:58264
type: Species
name: 4-ammoniobutanal
is: HMDB01080
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
constant: false

metaM c81crn e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: octenoyl carnitine
is: HMDB13324
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0

metaM Rtotalcoa c
type: Species
initial concentration: 1.0
is: CHEBI:16189
boundary condition: false
is: HMDB01448
name: R total Coenzyme A
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
is: SBO:0000247

metaM glyclt x
is: HMDB00115
name: glycolate
boundary condition: false
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_7d332a2d_d9da_4f9e_bba1_e9d8c5b89469
has only substance units: false
type: Species
is encoded by: hsa:1738
is: P09622
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: DLD
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_ebf830e7_788a_4b70_a249_d9b258decea8
constant: false
is encoded by: hsa:8310
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: ACOX3
is: O15254

http://identifiers.org/biomodels.db/MODEL1310110043#_c4f51b4c_653c_4a39_8f8b_8520990f2929
is: SBO:0000252
is encoded by: hsa:2517
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: FUCA1
is: P04066

metaR RE3626M
reactant: MODEL1310110043#
reversible: false
name: RE3626
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_4f4445d6_4e4a_43c8_aedb_5434f76d7c37
is encoded by: hsa:50614
boundary condition: true
initial concentration: NaN
name: GALNT9
is: Q9HCQ5
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_9eb53c03_47fc_4593_9d8d_4b67ec777f7d
is: SBO:0000252
initial concentration: NaN
is: Q9NZJ6
has only substance units: false
initial amount: NaN
name: COQ3
type: Species
boundary condition: true
is encoded by: hsa:51805
constant: false

metaM din c
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00071
is: SBO:0000247
is: C05512
type: Species
name: Deoxyinosine
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: CHEBI:28997
constant: false
initial amount: NaN

metaR ADCim
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
name: Acetoacetate decarboxylation (irreversible), mitochondrial
type: Reaction
reversible: false

metaR S6T6g
is: SBO:0000176
reversible: false
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
type: Reaction
fast: false

metaR B3GNT31g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000269
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110043#
is: SBO:0000176
fast: false
reversible: false

metaR PHEyLATthc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM man1p c
initial amount: NaN
is: CHEBI:35374
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: SBO:0000247
is: HMDB06330
initial concentration: 1.0
name: D-Mannose 1-phosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_2db142be_e518_4a52_88a5_0d5808a110a6
boundary condition: true
name: DPYSL2
is encoded by: hsa:1808
type: Species
has only substance units: false
initial amount: NaN
is: B4DR31
constant: false
is: SBO:0000252
initial concentration: NaN

metaM tetpent6coa x
type: Species
constant: false
is: C16172
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_aa1ad5a5_8945_4880_883b_f4db29b7eb22
is: P07101
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: TH
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7054

metaR C3STDH1r
modifier: MODEL1310110043#
reversible: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
product: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_e2999c88_9310_49f8_ae5e_ffa4c843f77b
initial amount: NaN
constant: false
name: SDHA
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P31040
type: Species
boundary condition: true
is encoded by: hsa:6389

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM c81crn c
initial concentration: 1.0
is: HMDB13324
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: octenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110043#_e3e8ec5f_a435_44d1_a173_75d0c25f2744
is: SBO:0000252
is encoded by: hsa:240
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: ALOX5
is: P09917
has only substance units: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8cd72bf6_0244_474e_96f6_d34f859de186
constant: false
type: Species
is encoded by: hsa:29922
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NME7
has only substance units: false

metaM ksii core4 pre6 g
notes: FORMULA: C69H111N6O51SX CHARGE: -2
has only substance units: false
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 6
is: CHEBI:28067
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR FACOAL140i
type: Reaction
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
name: fatty-acid--CoA ligase (tetradecanoate)
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_4bcab3f8_b5b9_415d_b594_7bdbc5c3c972
is encoded by: hsa:6531
constant: false
is: Q01959
has only substance units: false
initial concentration: NaN
name: SLC6A3
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM Ser Thr g
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB00645
notes: FORMULA: XH CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58336

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5f51a054_4aac_4184_a1d8_28edc01673c4
has part: B2RAU6
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9091
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:51227
is encoded by: hsa:5277
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: P57054
is encoded by: hsa:5279
has only substance units: false

metaR RE2759X
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/5.1.99.4
is described by: ECO:0000000
modifier: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
name: RE2759
fast: false
product: MODEL1310110043#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaM 4mzym int2 r
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB06838
name: 4-Methylzymosterol intermediate 2
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1

metaM sebacid x
is: C08277
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
initial amount: NaN
is: HMDB00792
name: sebacicacid
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR EX omeprazole LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: omeprazole exchange
type: Reaction

metaM orot5p c
is: CHEBI:57538
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false
boundary condition: false
is: C01103
initial concentration: 1.0
constant: false
is: HMDB00218
name: Orotidine 5'-phosphate
type: Species
is: SBO:0000247
initial amount: NaN

metaR CSND
name: Cytosine deaminase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR r1660
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7cd47fc7_dbe5_41a5_a114_6f975bda8371
type: Species
is: P00480
name: OTC
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5009
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_163c0e59_0bc3_4d5f_9757_347f528d230e
is encoded by: hsa:4645
initial amount: NaN
constant: false
boundary condition: true
is: Q9H6Y6
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: MYO5B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_b617d0a8_4bf5_45f5_8fd3_b47f7a60ef39
has only substance units: false
constant: false
is encoded by: hsa:728226
type: Species
name: _728226_1_e
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r2090
fast: false
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185

metaM odecrn m
type: Species
initial concentration: 1.0
constant: false
name: octadecenoyl carnitine
is: C00412
is: HMDB01114
is: CHEBI:57394
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1

metaM hdca e
is: CHEBI:0
is: C00249
initial amount: NaN
name: Hexadecanoate (n-C16:0)
notes: FORMULA: C16H31O2 CHARGE: -1
is: HMDB00220
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_c3223a76_baf6_4674_9698_b32fdcd53bc7
name: COASY
initial amount: NaN
is encoded by: hsa:80347
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q13057

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaM HC02202 e
is: CHEBI:57398
name: prostaglandin A1(1-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

metaM m6masnC g
has only substance units: false
type: Species
notes: FORMULA: C58H97N2O45X CHARGE: 0
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN
is: HMDB00573
constant: false
boundary condition: false
is: CHEBI:30825
is: SBO:0000247

metaM glu5sa m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02104
is: CHEBI:17232
is: SBO:0000247
type: Species
name: L-Glutamate 5-semialdehyde
is: C01165
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9e3fe3ce_2af3_4b97_a811_442e6361c59f
has only substance units: false
name: AQP9
is: SBO:0000252
type: Species
is: O43315
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:366

http://identifiers.org/biomodels.db/MODEL1310110043#_dd93f199_2c2e_412a_a32e_1a4da233f10f
constant: false
is encoded by: hsa:81537
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: SGPP1
has only substance units: false
is: SBO:0000252
is: Q9BX95

metaR r1661
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110043#
modifier: MODEL1310110043#

metaM mpdol U c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:18396
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR FAOXC18480m
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
name: Beta oxidation of fatty acid
is: SBO:0000176
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM 10fthf6glu e
is: SBO:0000247
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: CHEBI:57454
initial concentration: 1.0
is: HMDB00972
initial amount: NaN
constant: false
name: 10-formyltetrahydrofolate-[Glu](6)
boundary condition: false
has only substance units: false

metaR r2091
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FAOXC164m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110043#
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM xol7aone r
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17899
is: HMDB01993
boundary condition: false
has only substance units: false

metaR EX 3deccrn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaR G6PDH2rer
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
fast: false

metaR CYOOm3
product: MODEL1310110043#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.9.3.1
fast: false
reactant: MODEL1310110043#
name: cytochrome c oxidase, mitochondrial Complex IV
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7719b747_2212_4437_bd62_042ec5977c88
constant: false
initial concentration: NaN
is encoded by: hsa:220
is: P47895
type: Species
is: SBO:0000252
name: ALDH1A3
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r1662
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM bildglcur c
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
initial amount: NaN
boundary condition: false
is: CHEBI:58471
type: Species
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaM hdca c
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
has only substance units: false
is: HMDB00220
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:7896
name: palmitate

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
name: 3',5'-cyclic-nucleotide phosphodiesterase
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.4.35
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_001c12ac_1a68_4417_964f_f973cdb3018d
name: ATG9B
is: Q674R7
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:285973

metaR r2092
modifier: MODEL1310110043#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR FUCASE2e
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, extracellular
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false

metaM HC02202 c
name: prostaglandin A1(1-)
is: CHEBI:57398
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false

metaM utp n
is: HMDB00285
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:46398
name: UTP(4-)
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_982bc078_9a86_4953_92b1_658069c978a5
name: HPGDS
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27306
is: O60760

http://identifiers.org/biomodels.db/MODEL1310110043#_939a1732_45cd_47e8_ba25_cdd155338014
is: P50443
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: SLC26A2
boundary condition: true
is encoded by: hsa:1836
has only substance units: false
type: Species

metaM Ser Thr l
type: Species
notes: FORMULA: XH CHARGE: 0
is: CHEBI:58190
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00224
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR GMAND
is version of: http://identifiers.org/ec-code/4.2.1.47
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
modifier: MODEL1310110043#
is: SBO:0000176
reversible: false
name: GDP-D-mannose dehydratase
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
fast: false

metaR FAOXC5C3x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaM HC02023 r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Cholesterol-ester-ol
is: SBO:0000247
type: Species
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: CHEBI:46898
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_685dda4e_4eb8_4c17_a6dd_1ab3db38baca
name: SLC27A5
is: SBO:0000252
is encoded by: hsa:10998
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: Q9Y2P5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_4b79c407_1297_4564_ac95_fd5649ced0c8
has only substance units: false
is encoded by: hsa:2954
name: GSTZ1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: A6NED0

http://identifiers.org/biomodels.db/MODEL1310110043#_1198b1a0_1a60_4ad2_ab8e_a73da0bf35a3
is encoded by: hsa:5143
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PDE4C
is: Q7KYS4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_0853ac7a_c159_4056_a29b_22634148f67e
name: PDE6G
initial amount: NaN
is encoded by: hsa:5148
boundary condition: true
type: Species
is: P18545
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaM sucsal m
constant: false
is: HMDB01259
initial concentration: 1.0
has only substance units: false
is: CHEBI:57706
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
boundary condition: false
name: Succinic semialdehyde

metaR TPI
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true
name: triose-phosphate isomerase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.1
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
product: MODEL1310110043#

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
type: Reaction
reversible: false

metaM mmcoa R m
name: (R)-methylmalonyl-CoA(5-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57326
is: HMDB01269
initial concentration: 1.0
constant: false

metaR SUCD1m
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110043#
name: succinate dehydrogenase
is described by: ECO:0000134
modifier: MODEL1310110043#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2df9050e_bf49_4f2b_8065_93245e032706
constant: false
is encoded by: hsa:5320
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PLA2G2A
type: Species
is: P14555

metaR r2413
kinetic law: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
fast: false
product: MODEL1310110043#

metaM hxcoa m
has only substance units: false
is: SBO:0000247
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR RETI1
name: retinol isomerase (11-cis)
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_594bb985_d76f_404a_806a_d0c24d7fe816
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9BYC2
type: Species
has only substance units: false
name: OXCT2
is encoded by: hsa:64064

metaR UMPK6n
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110043#
fast: false
name: UMP kinase (dCTP),nuclear
product: MODEL1310110043#

metaR RE0691C
product: MODEL1310110043#
is: SBO:0000176
name: RE0691
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110043#

metaR r0560
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is: SBO:0000176
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9a05a96f_2e8e_4a9a_a887_ce996fcb80e0
is: P78428
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7054
type: Species
name: TH

metaM bildglcur e
initial concentration: 1.0
constant: false
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
is: CHEBI:58471
type: Species
is: HMDB03325
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
boundary condition: false

metaM gmp e
boundary condition: false
name: GMP(3-)
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:58115
is: HMDB01397
has only substance units: false
constant: false
is: SBO:0000247

metaR r1664
name: Y+LAT2 Utilized transport
modifier: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_26af3e9f_7bcb_40d3_81a2_76bb535abb00
boundary condition: true
name: SLC13A4
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:26266
is: Q9UKG4

metaR RE2426C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
is: SBO:0000176
name: RE2426

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM oh1 e
is: HMDB01039
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: hydroxide ion
initial amount: NaN
has only substance units: false
is: C01328
notes: FORMULA: HO CHARGE: -1

metaR DHDPBMTm
fast: false
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is: SBO:0000176
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.1.114
name: dihydroxydecaprenylbenzoate methyltransferase
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_a37b143f_9654_4dc8_b5f0_c890e0e1c85d
is: Q6ZMR3
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:160287
has only substance units: false
name: LDHAL6A
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_d5628883_795e_4e4f_87d8_386456316011
constant: false
name: GART
initial amount: NaN
is: SBO:0000252
is: P22102
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2618

metaR RE1897C
product: MODEL1310110043#
reversible: true
fast: false
type: Reaction
name: RE1897
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reactant: MODEL1310110043#

metaM ocdcea r
is: C00712
initial amount: NaN
is: HMDB00207
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
name: octadecenoate (n-C18:1)
has only substance units: false

metaM prgnlone m
is: CHEBI:16581
initial amount: NaN
constant: false
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
type: Species
has only substance units: false
is: HMDB00253
boundary condition: false
initial concentration: 1.0
name: pregnenolone
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_49b2ef5b_f116_488a_a470_23e9648330b3
is encoded by: hsa:N63787
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: _N63787_1_c
is: SBO:0000252
initial amount: NaN

metaR C4tcx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaR r1665
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110043#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_38c4ee5b_b90d_4333_a4ca_9f04cf613c24
has only substance units: false
boundary condition: true
is: Q549M5
type: Species
is encoded by: hsa:4718
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NDUFC2
constant: false

metaR CAROtr
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: beta-carotene transport via diffusion
fast: false
reactant: MODEL1310110043#

metaR PEAMNO
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is described by: ECO:0000304
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_acf29470_167e_4d0c_85ca_0d39e29f016c
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P54687
name: BCAT1
is encoded by: hsa:586

metaM tcynt m
is: SBO:0000247
is: CHEBI:18022
is: HMDB01453
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial concentration: 1.0
constant: false
name: thiocyanate
initial amount: NaN
type: Species
has only substance units: false

metaR SIAT9g
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.9
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reversible: false
is: SBO:0000176
product: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM prist x
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
boundary condition: false
is: CHEBI:51340
initial concentration: 1.0
is: HMDB00795
type: Species
constant: false
is: SBO:0000247
name: pristanic acid
initial amount: NaN
has only substance units: false

metaM cs c deg5 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
is: CHEBI:15936
constant: false
boundary condition: false

metaR LEUTAm
name: leucine transaminase, mitochondrial
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_9b14c154_abd4_42ed_8f8a_ef56516b2fba
initial concentration: NaN
type: Species
name: CA5B
boundary condition: true
has only substance units: false
is encoded by: hsa:11238
initial amount: NaN
constant: false
is: SBO:0000252
is: Q9Y2D0

http://identifiers.org/biomodels.db/MODEL1310110043#_1a289748_0cd5_4138_87ba_47b9e8401c51
name: ACO2
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:50
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: Q99798

metaR PAFt
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000185
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR r1666
reactant: MODEL1310110043#
name: Y+LAT2 Utilized transport
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_1ce18538_a219_4e78_8a39_0e4d2be70989
is encoded by: hsa:55350
is encoded by: hsa:8875
has part: O95498
is: SBO:0000297
name: VNN3:VNN2:VNN1
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_f683e1f1_d6fc_4534_88ea_f6b55ef56975
is: SBO:0000252
initial concentration: NaN
name: _D29675_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:D29675
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_93d82383_c2d5_4989_9f6e_7451061d9364
is: B3KUK6
name: NT5C1B
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:93034
initial concentration: NaN
initial amount: NaN
constant: false

metaR HOCDACBP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR RE3565C
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3565
product: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_4d154448_5e7b_4359_9bb2_dd81edebafa2
constant: false
is: B3KT86
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:109
name: ADCY3
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaM gmp g
name: GMP(3-)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
is: CHEBI:58115
has only substance units: false
is: HMDB01397
boundary condition: false
type: Species
initial amount: NaN

metaR DM anth
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_fee6295e_6944_4abc_95ab_d13163f943ef
boundary condition: true
is encoded by: hsa:1717
initial amount: NaN
constant: false
is: Q9UBM7
name: DHCR7
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR FACOAL180i
reactant: MODEL1310110043#
name: C180 fatty acid activation
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_95f8aad3_8f64_4ea1_90d7_e263859131f1
is encoded by: hsa:223
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: ALDH9A1
initial amount: NaN
is: SBO:0000252
is: P49189
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_98624fc4_1cf9_47ab_b552_23bc1c022682
constant: false
boundary condition: true
has only substance units: false
name: PLA2G6
initial amount: NaN
is: A8K460
type: Species
is encoded by: hsa:8398
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_584b89c4_b53b_4910_abde_5816b41baffd
constant: false
is encoded by: hsa:3948
type: Species
has only substance units: false
is: P07864
name: LDHC
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR r0668
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
product: MODEL1310110043#
modifier: MODEL1310110043#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.19
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000

metaM lnlnca e
is: SBO:0000247
name: alpha-linolenate
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
initial amount: NaN
is: HMDB01388
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaM glyald c
is: HMDB01051
type: Species
initial amount: NaN
is: CHEBI:17378
constant: false
boundary condition: false
name: D-Glyceraldehyde
is: C00577
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaM c4crn c
notes: FORMULA: C11H21NO4 CHARGE: 0
constant: false
is: HMDB02013
is: C02862
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
name: butyryl carnitine

metaR RE0688E
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
name: RE0688
reversible: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110043#
fast: false

metaM Rtotal c
is: SBO:0000247
constant: false
name: R total
type: Species
is: CHEBI:16189
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
is: HMDB01448

metaR FAOXTC102C101m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM acetone e
constant: false
initial concentration: 1.0
is: HMDB01659
initial amount: NaN
name: acetone
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15347

metaM mescon m
name: Mesaconate
is: CHEBI:36986
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
is: HMDB00749
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_71460d5c_4088_4f5c_980c_0879abde205f
initial amount: NaN
has only substance units: false
is encoded by: hsa:43
name: ACHE
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_6837e807_1b25_4716_969f_c32d5fb0a014
name: SLC22A3
constant: false
is encoded by: hsa:6581
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q5SYN6
initial amount: NaN

metaM HC01602 c
has only substance units: false
boundary condition: false
is: C00234
name: 10-Formyltetrahydrofolate
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
is: CHEBI:57454
initial concentration: 1.0
initial amount: NaN
type: Species

metaM tetdec2coa c
is: HMDB02014
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: tetradecadienoylcoa
initial concentration: 1.0
type: Species
constant: false

metaM HC01459 x
type: Species
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27458
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110043#_d628a840_5c1a_4cf5_9ba3_f0eb1d752699
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: ACP1
is encoded by: hsa:52
is: Q59EH3

metaR KCC2t
is described by: ECO:0000269
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
fast: false

metaM fe2 c
is: CHEBI:29033
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00692
is: C00023
boundary condition: false
name: Fe2+
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

metaR S6TASE10ly
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_6d4b503a_ce55_4fdf_81b7_76d75b753408
name: A4GNT
is: Q9UNA3
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:51146
is: SBO:0000252

metaM amp c
is: HMDB00045
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: C00020
is: CHEBI:3322
name: AMP
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_6fb33a05_02ba_4fbc_a6b9_18030222e68f
is encoded by: hsa:2584
boundary condition: true
name: GALK1
is: P51570
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM lnlnca c
constant: false
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
is: CHEBI:32387
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01388

metaM 5pmev c
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (R)-5-phosphonatomevalonate(3-)
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
type: Species
is: HMDB01343
constant: false
initial concentration: 1.0
initial amount: NaN

metaR BHBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reactant: MODEL1310110043#
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000185

metaM amp e
is: HMDB00045
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:456215
is: C00020
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
name: AMP
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_96209f19_8dd7_4ebe_b30d_cb7c71cc47f5
is: SBO:0000252
name: NIT2
is encoded by: hsa:56954
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: Q9NQR4
type: Species
boundary condition: true

metaM ptth m
initial concentration: 1.0
is: HMDB03426
constant: false
initial amount: NaN
boundary condition: false
name: pantetheine
has only substance units: false
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
is: SBO:0000247

metaM c4crn e
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
name: butyryl carnitine
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/213144
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02013

metaR OLEICFATPtc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR r0714
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110043#
fast: false
reversible: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction

metaR TXASr
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/5.3.99.5
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Thromboxane-A synthase

http://identifiers.org/biomodels.db/MODEL1310110043#_2da6bd5e_3c51_4918_a991_fb2b663e9e11
type: Species
boundary condition: true
is: Q16739
has only substance units: false
name: UGCG
constant: false
is: SBO:0000252
is encoded by: hsa:7357
initial concentration: NaN
initial amount: NaN

metaR B3GNT36g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

metaR TETTET6t
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
name: fatty acid transport via diffusion
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#

metaR FACOAL191
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110043#

metaM CE1926 e
type: Species
is: SBO:0000247
is: HMDB00127
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
has only substance units: false
is: CHEBI:15748
boundary condition: false
constant: false

metaR PRASCS
type: Reaction
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
is described by: ECO:0000269
reversible: true

metaR r0669
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
fast: false

metaR FUT18g
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.69
product: MODEL1310110043#
modifier: MODEL1310110043#
name: Galactoside 2-alpha-L-fucosyltransferase 1

metaR FUMTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: true
name: Fumarate:thiosulfate antiport, mitochondrial
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#

metaM fe2 e
initial amount: NaN
is: CHEBI:29033
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Fe2+
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
is: HMDB00692
boundary condition: false
has only substance units: false

metaR r0715
is version of: http://identifiers.org/ec-code/6.3.2.5
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110043#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110043#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_7a68474d_f160_49ea_9027_a94297ca93ca
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: XDH
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:7498
is: P47989

metaR GBSIDEte
is described by: ECO:0000000
name: globoside transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
is: SBO:0000185
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: true
type: Reaction
fast: false

metaM duri c
is: CHEBI:16450
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00012
is: C00526
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR FATP1t
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
product: MODEL1310110043#
fast: false
type: Reaction
name: fatty acid electroneutral transport
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#

metaR HSD3A1r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110043#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true

metaM ach n
initial amount: NaN
name: acetylcholine
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
type: Species
is: HMDB00895

metaM ksii core2 pre1 g
is: CHEBI:28067
notes: FORMULA: C33H53N3O23X CHARGE: -1
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate II biosynthesis, precursor 1
initial amount: NaN
initial concentration: 1.0

metaR G14T18g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM retinal cis 9 c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
is: SBO:0000247
name: all-trans-retinal
constant: false
initial amount: NaN
is: HMDB01358
type: Species
has only substance units: false

metaR r2396
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_585db19d_e86c_4e43_9fad_653034eac8ba
name: SLC13A5
is: SBO:0000252
is: Q86YT5
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:284111
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_c05b2adb_2e55_4795_aff4_23d8effb29af
name: ENPP3
boundary condition: true
is: Q308M7
initial amount: NaN
constant: false
is encoded by: hsa:5169
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_60e80962_5a96_4b77_8674_418237e3a26d
type: Species
is: Q68CJ7
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:131669
initial concentration: NaN
name: UROC1

metaR SERGLNNaEx
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_d9dfd971_1c45_47b5_a9cf_a159f407a692
constant: false
has only substance units: false
boundary condition: true
type: Species
name: GALNT10
is encoded by: hsa:55568
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR EX tetdec2crn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ecb48cf9_e31e_496e_968f_447f1ffa9ffd
initial concentration: NaN
name: DHFR
constant: false
is encoded by: hsa:1719
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P00374

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR RE3242R
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
name: RE3242
reactant: MODEL1310110043#
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110043#

metaM octd11ecoa c
initial amount: NaN
name: 11-octadecenoylcoa
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280771
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0

metaM HC01399 m
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial concentration: 1.0
is: CHEBI:27466
is: SBO:0000247
boundary condition: false
name: (S)-3-Hydroxytetradecanoyl-CoA
constant: false
has only substance units: false
type: Species

metaM 10fthf c
is: SBO:0000247
has only substance units: false
is: CHEBI:57454
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
name: 10-Formyltetrahydrofolate
is: HMDB00972
boundary condition: false
is: C00234

metaR DESAT24 1
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_d142db55_96f0_46da_bb37_c2c2e87d630c
is encoded by: hsa:91734
name: IDI2
initial amount: NaN
is: SBO:0000252
is: Q9BXS1
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR AKGMALtm
name: alpha-ketoglutarate/malate transporter
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is described by: ECO:0000269
modifier: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM duri e
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
is: SBO:0000247
constant: false
name: Deoxyuridine
type: Species
has only substance units: false
is: C00526
initial concentration: 1.0
boundary condition: false
is: HMDB00012

http://identifiers.org/biomodels.db/MODEL1310110043#_6abe8a5f_4670_4cfd_8c5e_6468f8d1f8b6
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:3156
is: SBO:0000252
initial amount: NaN
is: P04035
name: HMGCR
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_1713fa15_5a14_47f4_9709_cc292ea66541
is: SBO:0000252
name: PPCS
is encoded by: hsa:79717
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: Q9HAB8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_7a898bd2_38f2_450f_8b49_bd5a52582c3b
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: Q99624
is encoded by: hsa:10991
has only substance units: false
name: SLC38A3
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_169fd56a_e284_417a_aeab_47b40b6ba7fb
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PDE9A
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5152
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_fa1847d1_4c95_4447_b90f_d8a80d9ed7e2
boundary condition: true
is encoded by: hsa:5238
name: PGM3
is: B4DX94
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaM cs a l
initial amount: NaN
is: HMDB02183
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:36005
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
boundary condition: false
type: Species

metaM xol7ah3 c
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB12455
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: CHEBI:28540
initial amount: NaN
type: Species
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaR r0666
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
modifier: MODEL1310110043#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: true

metaM hexe3coa x
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06522
initial amount: NaN
name: 3-hexenoylcoa
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaR NACHEX11ly
fast: false
reversible: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110043#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is: SBO:0000176

metaR FAOXC226C225x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaM Rtotal e
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
is: C00255
name: R total
is: HMDB00244
initial amount: NaN
boundary condition: false
is: CHEBI:3554
has only substance units: false
constant: false
type: Species

metaR RPEc
reversible: true
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110043#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
is: SBO:0000176

metaR F6Tg
is described by: ECO:0000000
reactant: MODEL1310110043#
name: glycoprotein 6-alpha-L-fucosyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.68
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5cf6946e_6b40_42a4_a24f_2c7778099f82
name: CYP51A1
is: Q16850
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1595
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_ce3d3bca_d921_4ee5_84d7_b5fc5769a856
type: Species
boundary condition: true
initial concentration: NaN
name: GUCY1B2
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2974
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7d0dbe7b_057a_4964_8bef_3e9bbf21698f
constant: false
is: E7EX19
name: PIK3R1
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5295
boundary condition: true
initial concentration: NaN

metaM 10fthf e
name: 10-formyltetrahydrofolate(2-)
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00972
constant: false
is: CHEBI:57454
has only substance units: false

metaR GLNtm
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000

metaM grdp x
is: CHEBI:58057
name: geranyl diphosphate(3-)
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: HMDB01285
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_cb2e4f87_15cc_4b1a_b8cc_bc241d81c000
name: RDH14
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9HBH5
boundary condition: true
constant: false
is encoded by: hsa:57665

metaR 2AMACHYD
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110043#
type: Reaction
name: 2-Aminoacrylate hydrolysis
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM nh4 n
initial amount: NaN
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
initial concentration: 1.0
is: HMDB00051
constant: false
is: SBO:0000247
type: Species
name: ammonium
boundary condition: false

metaM zym int2 r
boundary condition: false
is: CHEBI:52386
type: Species
is: SBO:0000247
name: zymosterol intermediate 2
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
constant: false
initial concentration: 1.0

metaM nh4 m
is: HMDB00051
is: CHEBI:28938
is: SBO:0000247
constant: false
type: Species
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
has only substance units: false
name: Ammonium
initial concentration: 1.0
is: C01342

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR CYTK6n
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
reversible: true
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,CTP),nuclear

metaM lneldccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: SBO:0000247
constant: false
type: Species
name: Linoelaidyl carnitine
is: HMDB06461
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaM m8masn g
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C05876

metaM acetone m
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
is: HMDB01659
name: acetone
initial concentration: 1.0
is: CHEBI:15347
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaM 4mtolbutamide c
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C12H18N2O4S CHARGE: 0 INCHI: InChI=1/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
boundary condition: false
constant: false
is: HMDB06408
is: SBO:0000247
initial concentration: 1.0
name: 4 hydroxy tolbutamide

http://identifiers.org/biomodels.db/MODEL1310110043#_8f67a8ce_5e1d_4dc6_bb0f_1d4e662f88e3
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC5A10
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:125206
initial concentration: NaN
is: A0PJK1

http://identifiers.org/biomodels.db/MODEL1310110043#_03d6030f_209a_41ae_88ae_160674c4bffc
has only substance units: false
is: SBO:0000252
type: Species
name: SLC16A3
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O15427
is encoded by: hsa:9123

http://identifiers.org/biomodels.db/MODEL1310110043#_2ae28da6_bd1e_40ab_81d6_2c9fcb6efd31
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:622
constant: false
initial concentration: NaN
name: BDH1

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM fol e
type: Species
boundary condition: false
constant: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Folate

metaM arachdcoa x
is: SBO:0000247
type: Species
name: arachidonoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
is: HMDB06523
constant: false
initial amount: NaN
is: CHEBI:57368
initial concentration: 1.0

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaM HC02210 c
initial amount: NaN
is: CHEBI:34939
name: prostaglandin-d3
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1

metaR PDE4
is version of: http://identifiers.org/ec-code/3.1.4.35
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.17
type: Reaction
modifier: MODEL1310110043#
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110043#
reversible: false

metaR MG1er
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.106
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110043#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR GALGALGALTHCRMte
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
name: galgalgalthcrm hs transport

http://identifiers.org/biomodels.db/MODEL1310110043#_942e2533_fb52_4f09_820f_16ac01cd8b96
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4846
initial amount: NaN
name: NOS3
boundary condition: true
is: SBO:0000252
is: A0S0A7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_afda5953_ef2a_4d60_b8b9_2cd8332dba55
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:8396
name: PIP4K2B
is: P78356
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_efc1acc9_0f1f_4d27_9ca2_a49af1c7f2e8
type: Species
is: SBO:0000252
is encoded by: hsa:PRO1933
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _PRO1933_1_m

metaR PPNCL3
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110043#
name: phosphopantothenate-cysteine ligase
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
product: MODEL1310110043#

metaM nh4 c
boundary condition: false
has only substance units: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
type: Species
is: SBO:0000247
initial amount: NaN
name: Ammonium
is: HMDB00051
initial concentration: 1.0
constant: false

metaM HC00900 c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:30860
initial concentration: 1.0
name: Methylmalonate

metaR EHGLATm
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is described by: ECO:0000212
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_1b22413e_dd46_42d6_8a0e_94b900fe751f
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: RBKS
constant: false
is encoded by: hsa:64080
type: Species
is: Q9H477
initial concentration: NaN

metaM pan4p c
initial amount: NaN
is: HMDB01416
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942
name: Pantetheine 4'-phosphate
initial concentration: 1.0
constant: false
is: C01134
boundary condition: false
type: Species
has only substance units: false

metaM hs deg14 l
type: Species
is: CHEBI:16126
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
initial concentration: 1.0
name: heparan sulfate, degradation product 14

metaM lgnccoa c
has only substance units: false
name: lignocericyl coenzyme A
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
constant: false
initial concentration: 1.0
is: HMDB06526

http://identifiers.org/biomodels.db/MODEL1310110043#_04c84e94_1be6_4a0b_a980_0d4623a31b78
constant: false
is encoded by: hsa:6822
initial concentration: NaN
name: SULT2A1
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: Q06520

metaM succoa x
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
constant: false
initial concentration: 1.0
is: HMDB01022
boundary condition: false
name: Succinyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_35c5852d_c3d9_4aa3_a7e5_84b54e6ca281
is: SBO:0000252
has only substance units: false
is encoded by: hsa:64078
is: Q9HAS3
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: SLC28A3
type: Species

metaM fol c
name: Folate
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00121

metaM noncoa m
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: C01942
initial concentration: 1.0
has only substance units: false
name: nonanoylcoa
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB13028

metaM pchol hs c
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
constant: false
is: CHEBI:16110
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_6f6e197b_33fb_45e4_8681_5dca196f01ce
initial amount: NaN
is encoded by: hsa:6482
constant: false
initial concentration: NaN
is: Q11201
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ST3GAL1

metaR CMPACNAtn
reversible: false
name: CMP-Sia nuclear export
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110043#
is: SBO:0000185

metaR GBSIDEtl
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
is: SBO:0000185
name: globoside intracellular transport
product: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_c1250102_fec0_48c0_a6c7_d5dc1a5893d3
boundary condition: true
name: NT5C2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:22978
initial concentration: NaN
constant: false
type: Species
is: P49902
has only substance units: false

metaR NACHEXA18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false

metaM 4mtolbutamide e
type: Species
has only substance units: false
constant: false
is: HMDB06408
is: SBO:0000247
notes: FORMULA: C12H18N2O4S CHARGE: 0 INCHI: InChI=1/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 4 hydroxy tolbutamide

http://identifiers.org/biomodels.db/MODEL1310110043#_b0bede34_d816_4dba_a3c1_8b7242ac05a8
constant: false
is: E5KSL6
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: DGUOK
initial concentration: NaN
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110043#_f151763a_292f_4d6e_a01d_4fd1fd44e60b
boundary condition: true
initial concentration: NaN
name: _AI656480_1_m
is encoded by: hsa:AI656480
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaM Rtotal3coa c
is: HMDB01448
is: SBO:0000247
is: CHEBI:16189
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
name: R total 3 Coenzyme A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_fa1d64b8_92ec_4da4_a3ba_f799efebed95
has only substance units: false
initial concentration: NaN
name: NDUFA6
boundary condition: true
type: Species
is: P56556
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4700

metaR ACt2m
reversible: true
is: SBO:0000185
product: MODEL1310110043#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
type: Reaction
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_7a3caccb_41b3_432c_bcd9_3592798084c9
is encoded by: hsa:7108
constant: false
initial amount: NaN
is: SBO:0000252
name: TM7SF2
is: O76062
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_40d91fc2_611e_4e78_b9cd_b7037ea0546b
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PDE1B
type: Species
initial amount: NaN
is: Q7Z364
is encoded by: hsa:5153
constant: false
has only substance units: false

metaR GALGALGALTHCRMtg
product: MODEL1310110043#
type: Reaction
name: galgalgalthcrm hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
reversible: true
is: SBO:0000185

metaM phyt2ohcoa x
constant: false
type: Species
name: 2-hydroxyphytanoyl-CoA(4-)
is: CHEBI:57334
has only substance units: false
is: HMDB01295
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
initial amount: NaN
initial concentration: 1.0

metaR CREATt4 2 r
is described by: ECO:0000269
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Creatine transport (sodium symport) (2:1)
product: MODEL1310110043#
modifier: MODEL1310110043#

metaM amp m
type: Species
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
boundary condition: false
name: AMP(2-)
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR TTDCRNt
kinetic law: MODEL1310110043#
reversible: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM guln c
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
name: L-gulonate
is: HMDB03290
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:13115
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_91148550_88fc_45c8_a12e_7c60dee242ee
is: SBO:0000252
name: _AI191472_1_c
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI191472
constant: false
boundary condition: true
initial concentration: NaN

metaR HTDCACBP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR DPMVDc
name: diphosphomevalonate decarboxylase, cytosol
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.1.1.33
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is described by: ECO:0000134
reversible: false
fast: false
product: MODEL1310110043#

metaM pan4p e
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2
has only substance units: false
is: CHEBI:47942
constant: false
initial concentration: 1.0
name: Pantetheine 4'-phosphate
is: C01134
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01416

metaR DHCHOLESTANATEtm
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
name: lipid, flip-flop intracellular transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_0de1c5dc_f400_4c22_b8a6_e9c13d7f3cec
is: Q5JAM2
name: ALAS1
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:211
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR r0556
is: SBO:0000176
is described by: ECO:0000000
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.14.19.1

metaM 4nph e
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
name: 4-nitrophenolate
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: HMDB01232
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57917

metaR FAOXC246226x
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110043#_ab25f3c9_b935_46b6_aa6b_d77af944e4d4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P16499
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: PDE6A
is encoded by: hsa:5145

http://identifiers.org/biomodels.db/MODEL1310110043#_aec1a6ec_6d9d_4620_ad2d_f4589c692875
boundary condition: true
name: SLC25A11
type: Species
initial amount: NaN
is encoded by: hsa:8402
is: F5GY65
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR FAOXC5OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM octd11ecoa m
is: HMDB06294
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 11-octadecenoylcoa
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR GLCAASE6ly
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110043#
type: Reaction
name: beta-glucuronidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110043#_4eb70e84_810a_4ae9_84d2_3b1d74ab09e1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AL048840
constant: false
name: _AL048840_1_c
initial amount: NaN

metaR AG13T8g
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_ccae0471_1e04_4af4_ad5d_96ec34299fb4
is encoded by: hsa:80724
initial amount: NaN
constant: false
is: G3XAJ0
boundary condition: true
name: ACAD10
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR FUMm
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
name: fumarase, mitochondrial
fast: false
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
reversible: true
product: MODEL1310110043#

metaM duri n
initial amount: NaN
boundary condition: false
name: 2'-deoxyuridine
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00012

http://identifiers.org/biomodels.db/MODEL1310110043#_f1d9bd27_50e3_4adc_b84c_e439d98ef2e2
is encoded by: hsa:6567
type: Species
name: SLC16A2
is: SBO:0000252
is: P36021
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR DESAT22 1p
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
kinetic law: MODEL1310110043#

metaR DCK1n
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (ATP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
fast: false
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_071d3a4d_3091_4b3b_91f7_deb589458049
boundary condition: true
is encoded by: hsa:6185
has only substance units: false
constant: false
name: RPN2
initial concentration: NaN
is: P04844
initial amount: NaN
type: Species
is: SBO:0000252

metaM CE5161 r
type: Species
is: CHEBI:57923
constant: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r0559
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9dc751e7_043a_47e5_b2e9_e3bd7e18eda1
boundary condition: true
is encoded by: hsa:55350
name: VNN3
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR FAOXC227C226m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_cd931ce8_60fa_4965_9a56_765837a79bb3
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: NDUFA5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4698
type: Species
is: Q16718

metaM lneldccrn c
name: Linoelaidyl carnitine
constant: false
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
initial amount: NaN
is: HMDB06461
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR CSNATr
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reversible: true
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
name: carnitine O-acetyltransferase

metaR NADPHtxu
kinetic law: MODEL1310110043#
fast: false
name: NADPH transporter, peroxisome
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ

metaR FAOXC226C225m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_c25c2450_551b_49ed_9305_78677e90b37d
name: SGSH
is: SBO:0000252
is: P51688
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6448
constant: false

metaM 6pgc r
is: HMDB01316
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
name: 6-phosphonatooxy-D-gluconate
constant: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: CHEBI:58759
boundary condition: false

metaR 4MPTNLte
fast: false
reversible: true
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: 4-methylpentanal transport
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_21de4f3f_d916_4c0b_9581_b2ab31c0b3d9
is: B3KUN3
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:191
name: AHCY
is: SBO:0000252
type: Species

metaM 1glyc hs e
is: CHEBI:57454
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
constant: false
has only substance units: false
is: HMDB00972
initial amount: NaN
name: 1 acyl phosphoglycerol
boundary condition: false

metaM ksi pre28 g
boundary condition: false
is: CHEBI:58053
type: Species
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: C00130
is: HMDB00175
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 28
initial amount: NaN
initial concentration: 1.0
constant: false

metaM r5p c
constant: false
is: C00117
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
is: HMDB00618
has only substance units: false
is: SBO:0000247
name: alpha-D-Ribose 5-phosphate
is: CHEBI:18189
initial concentration: 1.0
type: Species

metaM ach e
boundary condition: false
has only substance units: false
is: HMDB00895
initial amount: NaN
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15355
constant: false
name: acetylcholine

http://identifiers.org/biomodels.db/MODEL1310110043#_026b6071_83a9_4f79_a448_8ff493bdcf92
boundary condition: true
is encoded by: hsa:518
initial concentration: NaN
constant: false
is: SBO:0000252
name: ATP5G3
type: Species
initial amount: NaN
has only substance units: false

metaR ACt2r
reversible: true
product: MODEL1310110043#
name: acetate reversible transport via proton symport
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_882a29d3_98d6_486e_9417_06552860904f
type: Species
name: PIP4K2A
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P48426
is encoded by: hsa:5305
initial amount: NaN
constant: false

metaR DOCO13EFATP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaM 4nph c
name: 4-nitrophenolate
initial amount: NaN
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01232

metaR r0558
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_71d8b16b_6b9d_44ca_824a_1ad719b7c584
is encoded by: hsa:55967
initial concentration: NaN
name: NDUFA12
initial amount: NaN
constant: false
is: F8VQS7
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR ASCBt
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: L-ascorbate transport via facilitated diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
type: Reaction
reactant: MODEL1310110043#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_7ab0dc0d_6ed7_4855_9243_1f46dd1c668b
has part: Q9BQL0
has only substance units: false
name: DBT:DLD:BCKDHA:BCKDHB
boundary condition: true
is: SBO:0000297
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:594

metaR TAUPAT1c
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

metaM acnamp c
is: CHEBI:27438
is: HMDB06268
has only substance units: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
is: SBO:0000247
type: Species
name: N-Acetylneuraminate 9-phosphate
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR NACDe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR GLUPRT
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.14
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110043#
name: glutamine phosphoribosyldiphosphate amidotransferase

metaM HC02210 e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: prostaglandin-d3
is: CHEBI:34939
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_2f49217e_efe3_4a9b_9877_97af0b734f92
is encoded by: hsa:8050
is: O00330
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: PDHX
type: Species

metaR PRGNLONESULT
is described by: ECO:0000269
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.14
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.2
is: SBO:0000176
type: Reaction
name: steroid sulfotransferase

http://identifiers.org/biomodels.db/MODEL1310110043#_75487345_abf0_4691_adc9_c2f654ee8194
is: SBO:0000252
is encoded by: hsa:4718
is: Q549M5
name: NDUFC2
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaR DINt
name: deoxyinosine transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
reactant: MODEL1310110043#
type: Reaction
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_3b8f4f6b_b6be_4725_85ea_3efbc8b6bbde
is encoded by: hsa:5287
is: SBO:0000252
name: PIK3C2B
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: O00750

http://identifiers.org/biomodels.db/MODEL1310110043#_192b9594_9208_4f6a_8c81_87575abd33d1
initial concentration: NaN
name: LDHD
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:197257
boundary condition: true
type: Species
has only substance units: false
is: Q86WU2

metaR SARCStm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110043#
is: SBO:0000185
name: Sarcosine transport (mitochondrial)
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaM pentcoa m
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
name: pentanoylcoa
is: C00888
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB13037

metaM nh4 e
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: ammonium
constant: false
is: HMDB00051
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_16940347_8dc8_42c2_a54b_c70e9941d690
initial amount: NaN
is encoded by: hsa:27010
initial concentration: NaN
is: SBO:0000252
type: Species
is: F5GZG6
has only substance units: false
constant: false
boundary condition: true
name: TPK1

http://identifiers.org/biomodels.db/MODEL1310110043#_ec0d7a81_7a41_4d96_9282_d7200b306f69
is encoded by: hsa:3931
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: LCAT
type: Species
is: SBO:0000252
is: P04180
constant: false
has only substance units: false

metaR 10FTHFtm
product: MODEL1310110043#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_5a0a93e7_304a_411e_ad96_93c5004d928e
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:955
is: O75354
boundary condition: true
name: ENTPD6

metaR CSNATp
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
modifier: MODEL1310110043#
is described by: ECO:0000304
kinetic law: MODEL1310110043#
reversible: true
fast: false
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reactant: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction

metaM amp r
is: HMDB00045
is: C00020
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
constant: false
has only substance units: false

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: RE0944
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM co e
initial concentration: 1.0
is: HMDB01361
name: carbon monoxide
is: CHEBI:17245
type: Species
has only substance units: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

metaM ach c
constant: false
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: acetylcholine
has only substance units: false
boundary condition: false
is: CHEBI:15355

http://identifiers.org/biomodels.db/MODEL1310110043#_2a6d8453_0558_4e01_8ec1_ab05a4c2c583
has only substance units: false
name: ALDH5A1
is: Q546H9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7915
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaR r1806
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR CSNATm
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
fast: false
is described by: ECO:0000269
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110043#
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
reversible: true
is: SBO:0000176

metaM co c
is: SBO:0000247
constant: false
is: CHEBI:17245
boundary condition: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: carbon monoxide

metaM dd3coa x
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB04257
initial concentration: 1.0
name: 3-dodecenoylcoa

metaM 2mbcoa m
name: 2-methylbutanoyl-CoA(4-)
has only substance units: false
is: CHEBI:57336
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01041

http://identifiers.org/biomodels.db/MODEL1310110043#_5039a094_f0a8_43d4_a97f_553e87c583e5
type: Species
has only substance units: false
name: _T83654_1_e
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:T83654
boundary condition: true

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
name: glycerol transport
fast: false
product: MODEL1310110043#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_71328582_3bb0_40d5_8da2_72d317d47b0f
is encoded by: hsa:6389
initial amount: NaN
name: SDHA
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: P31040
boundary condition: true

metaR NACHEXA2ly
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false
reversible: false
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#

metaM adp n
type: Species
has only substance units: false
is: CHEBI:456216
is: HMDB01341
initial concentration: 1.0
is: SBO:0000247
constant: false
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
initial amount: NaN

metaM ile L c
is: CHEBI:17191
initial concentration: 1.0
initial amount: NaN
is: HMDB00172
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110043#_599b3eb3_b0d6_48ec_a101_683a9fd5f9ca
constant: false
is: SBO:0000252
boundary condition: true
name: _AA664770_1_m
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA664770
type: Species
initial amount: NaN

metaM udp n
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: CHEBI:58223
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00295
boundary condition: false
name: UDP(3-)

metaM hom L c
type: Species
is: HMDB00719
constant: false
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false
name: L-homoserine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM HC00822 e
name: Chitobiose
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:28681
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

http://identifiers.org/biomodels.db/MODEL1310110043#_05a53bc6_7b91_4932_8d3a_5820dfc49d78
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q16831
constant: false
name: UPP1
boundary condition: true
type: Species
is encoded by: hsa:7378
is: SBO:0000252

metaR GCNTg
is version of: http://identifiers.org/ec-code/2.4.1.150
reversible: false
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
reactant: MODEL1310110043#

metaR FBA4
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
kinetic law: MODEL1310110043#
is described by: ECO:0000269
product: MODEL1310110043#
is: SBO:0000176
type: Reaction
reversible: true

metaR NDP7ex
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
name: nucleoside-diphosphatase (UDP), extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
reactant: MODEL1310110043#

metaR GGT6
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#
is: SBO:0000176
fast: false
name: Gamma-glutamyltransferase
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110043#

metaM adp m
is: HMDB01341
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:456216
name: ADP
boundary condition: false
is: C00008
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8833cc20_baae_4e0a_a34c_2b8185cbdcbe
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6553
boundary condition: true
constant: false
is: Q9NSW9
name: SLC9A5
type: Species
has only substance units: false

metaR AMETtd
reversible: true
product: MODEL1310110043#
name: diffusion of S-Adenosyl-L-methionine
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110043#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110043#

metaM arachdcoa m
initial concentration: 1.0
boundary condition: false
type: Species
name: arachidonoyl-CoA(4-)
is: HMDB06523
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110043#_6b49660e_f7b4_4f87_a1fc_b4785e997ed3
name: PPAP2C
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8612
type: Species
is: E9PAY8
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR MMSAD1m
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
fast: false
product: MODEL1310110043#
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase
modifier: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.27
kinetic law: MODEL1310110043#
reversible: false
type: Reaction
reactant: MODEL1310110043#

metaM 2mb2coa c
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB02054
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
name: 2-methylcrotonoyl-CoA(4-)
boundary condition: false

metaR AGMTm
type: Reaction
reactant: MODEL1310110043#
name: agmatinase (m)
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (79814.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 3.5.3.11 Confidence Level: 4 AUTHORS: PMID:11804860,PMID:11914032,PMID:15028567,PMID:15465778 NOTES:SAB m
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.3.11
product: MODEL1310110043#
reversible: false

metaR GLUPROASCT1
is described by: ECO:0000134
fast: false
reversible: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
modifier: MODEL1310110043#
name: glutamate intake by system ASCT-1 transporter
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction

metaR r1808
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
fast: false
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM ksii core2 pre9 g
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 9
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_6d41c8d2_bf1a_4d40_b11f_985b6465141c
is: Q7GXZ1
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: ND6
is encoded by: hsa:4541
type: Species

metaR BILIRED
fast: false
reversible: false
modifier: MODEL1310110043#
name: Nad(p)h biliverdin reductase
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.24
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#

metaM pan4p m
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01416
constant: false
name: pantetheine 4'-phosphate(2-)
type: Species
initial amount: NaN
has only substance units: false

metaM ile L e
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17191
is: HMDB00172
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110043#_d7118b3c_d9e0_4ad5_bcaa_ae90667ba4ba
type: Species
is: P32322
is encoded by: hsa:5831
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PYCR1

metaR r0339
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
is: SBO:0000176
modifier: MODEL1310110043#

metaM galgbside hs g
is: CHEBI:18259
has only substance units: false
name: galactosylgloboside
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
boundary condition: false

metaM udp l
is: CHEBI:58223
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: UDP(3-)
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_5affc346_03a3_4cc7_b5c4_ed435aa5cbb9
is encoded by: hsa:AI824319
has only substance units: false
name: _AI824319_1_r
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_de649019_b67a_4785_a121_9011d0cd94d7
has only substance units: false
is: Q13613
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8776
name: MTMR1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_9cddde93_502d_475a_a5b0_9dbe5998c536
type: Species
has only substance units: false
constant: false
boundary condition: true
is: P19801
initial amount: NaN
name: ABP1
initial concentration: NaN
is encoded by: hsa:26
is: SBO:0000252

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR AG13T9g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110043#
type: Reaction

metaM acald e
type: Species
has only substance units: false
is: HMDB00990
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:15343

metaR ACCOAgt
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: acetyl-coa transport
modifier: MODEL1310110043#

metaR RE3074X
name: RE3074
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_54c80a57_15a1_4b24_b58f_606fe60bf41c
is encoded by: hsa:10723
type: Species
initial amount: NaN
name: SLC12A7
constant: false
is: SBO:0000252
has only substance units: false
is: Q9Y666
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_a090242a_6533_4b68_8878_b323698a403b
constant: false
is: Q9NVE7
name: PANK4
initial concentration: NaN
is encoded by: hsa:55229
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_63ce6069_9a7d_44a3_8753_6c28ff8f7f66
type: Species
name: SRM
is: P19623
is encoded by: hsa:6723
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ksi deg5 l
boundary condition: false
is: CHEBI:12936
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
initial amount: NaN
is: HMDB00143
name: keratan sulfate I, degradation product 5

metaM hyptaur c
initial concentration: 1.0
type: Species
name: Hypotaurine
is: HMDB00965
is: SBO:0000247
constant: false
is: CHEBI:16668
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_69c4ea26_99c8_4dcc_a57e_128619df33c8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79053
type: Species
boundary condition: true
initial amount: NaN
name: ALG8
constant: false
has only substance units: false

metaM ksi pre33 g
has only substance units: false
initial concentration: 1.0
is: C00130
initial amount: NaN
type: Species
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 33
boundary condition: false
constant: false

metaM txa2 c
initial concentration: 1.0
is: HMDB01452
initial amount: NaN
name: thromboxane A2(1-)
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false
is: CHEBI:57445

metaM srtn e
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
has only substance units: false
is: CHEBI:350546
is: SBO:0000247
constant: false
is: HMDB00259
name: serotonin(1+)
type: Species
initial concentration: 1.0

metaM cs d deg3 l
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3
boundary condition: false
notes: FORMULA: C37H54NO41S3 CHARGE: -5
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:15748
is: HMDB00127
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_73d55e9a_d83a_48da_9b6e_a87cea9e4112
name: _AF080579_1_c
is: SBO:0000252
is encoded by: hsa:AF080579
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaM ksii core2 deg2 l
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
constant: false
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 2
initial concentration: 1.0
is: HMDB00143
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_e26a3e82_9d33_42a3_9de4_2efade185ffe
is encoded by: hsa:55326
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NUQ2
constant: false
name: AGPAT5
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_63c9b95c_0f0b_4c7e_bafa_dff2e618fd6a
initial concentration: NaN
name: GUCY1B3
is encoded by: hsa:2983
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: Q02153

metaR CLS hs
type: Reaction
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
name: cardiolipin synthase (homo sapiens)
product: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110043#

metaM udp r
name: UDP
has only substance units: false
type: Species
constant: false
is: HMDB00295
is: SBO:0000247
boundary condition: false
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: C00015

metaM cortsn r
initial amount: NaN
has only substance units: false
is: CHEBI:16962
name: cortisone
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
is: HMDB02802
type: Species

metaM malthx e
name: Maltohexaose
constant: false
is: SBO:0000247
initial amount: NaN
is: C01936
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_217eeba4_6744_4ecd_8997_423870ac4e7d
boundary condition: true
is encoded by: hsa:2643
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GCH1
type: Species
is: Q8IZH9
constant: false

metaR M4MPDOL Uter
kinetic law: MODEL1310110043#
is described by: ECO:0000000
name: m4mpdol flippase
reversible: false
product: MODEL1310110043#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_464f2708_50d7_46cd_8345_79cbba37cbc5
name: AFMID
is: SBO:0000252
is encoded by: hsa:125061
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: Q63HM1
initial concentration: NaN
constant: false

metaM acgal c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: N-acetyl-D-galactosamine
initial amount: NaN
boundary condition: false
is: CHEBI:28037
has only substance units: false

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_afbd7ba8_aca2_4bdf_ba77_f14c4738607b
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AA081045
is: SBO:0000252
name: _AA081045_1_e
has only substance units: false
boundary condition: true
constant: false

metaR ADKd
name: adenylate kinase (d form)
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM g1m8masn r
constant: false
initial amount: NaN
has only substance units: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: SBO:0000247
is: C05875

metaM 56dthm c
is: HMDB00079
initial concentration: 1.0
is: CHEBI:27468
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: 5,6-dihydrothymine
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
has only substance units: false

metaM em2emgacpail hs r
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
has only substance units: false
is: CHEBI:16038
boundary condition: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_e346e033_92d1_425c_9ea7_4b084b4facd7
boundary condition: true
is: SBO:0000252
name: SLC34A1
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6569
is: Q7Z725

metaM 2decdicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 2,7-decadienoylcoa
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_008233ff_f308_44c0_8e3e_006d421289c3
is: SBO:0000252
type: Species
boundary condition: true
name: CLYBL
is encoded by: hsa:171425
has only substance units: false
initial concentration: NaN
is: Q8N0X4
constant: false
initial amount: NaN

metaM pchol hs e
initial concentration: 1.0
is: CHEBI:16110
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: Phosphatidylcholine
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0

metaM stcrn m
boundary condition: false
name: stearoylcarnitine
initial amount: NaN
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00848

metaR r0552
is: SBO:0000176
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.5.1
product: MODEL1310110043#
type: Reaction
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_580413f2_db81_44f1_993e_1cf3f2bfb183
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: FOLR1
constant: false
type: Species

metaR S6T15g
is: SBO:0000176
kinetic law: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.21
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false

metaM srtn c
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
has only substance units: false
initial amount: NaN
name: serotonin(1+)
is: CHEBI:350546
is: SBO:0000247
constant: false
is: HMDB00259
initial concentration: 1.0
type: Species

metaM txa2 e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: thromboxane A2(1-)
constant: false
boundary condition: false
type: Species
is: CHEBI:57445
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_3e770c52_4fb1_4266_a77b_50b07d09e921
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: KHK
is: SBO:0000252
is: P50053
is encoded by: hsa:3795
has only substance units: false

metaR Q10H2e
is: SBO:0000185
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is described by: ECO:0000134
fast: false
reversible: true
type: Reaction
product: MODEL1310110043#
name: transport of ubiquinol into lymph

http://identifiers.org/biomodels.db/MODEL1310110043#_53ea76b0_74d0_454a_96b0_e2a8ad50f5b2
initial amount: NaN
name: SULT1A2
is: SBO:0000252
is encoded by: hsa:6799
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: P50226
has only substance units: false

metaM prostgh2 r
is: SBO:0000247
boundary condition: false
is: HMDB01381
is: CHEBI:57405
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
initial concentration: 1.0
name: prostaglandin H2(1-)
initial amount: NaN
type: Species

metaM maltttr e
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/5141
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Maltotetraose
type: Species
is: C02052
is: HMDB01296
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052

metaR r0553
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
product: MODEL1310110043#

metaM 34dhmald m
type: Species
initial amount: NaN
is: C05577
name: 3,4-Dihydroxymandelaldehyde
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
boundary condition: false
is: HMDB06242
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7903

metaR NH4tn
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
name: ammonia nuclear transport
type: Reaction
kinetic law: MODEL1310110043#
fast: false

metaM ctp n
is: HMDB00082
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
type: Species
initial amount: NaN
name: CTP(4-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_44333e71_dd06_4185_bbe0_404812e451d9
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5277
initial amount: NaN
name: PIGA
boundary condition: true

metaR OMEPRAZOLEte
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
fast: false
name: xenobiotic transport

metaR FBA2
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_59ec4288_95ee_4706_8c2e_26fce5b52b98
type: Species
is encoded by: hsa:6005
is: Q96E98
is: SBO:0000252
name: RHAG
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM HC00822 l
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: CHEBI:28681
boundary condition: false
type: Species
constant: false
name: Chitobiose
initial concentration: 1.0

metaR G14T5g
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110043#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110043#
reversible: false
is: SBO:0000176

metaR S23T4g
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.4
modifier: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
name: beta-galactoside alpha-2,3-sialyltransferase
reactant: MODEL1310110043#

metaR 3HBCOAHLm
reversible: false
reactant: MODEL1310110043#
fast: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110043#_01727c81_ed62_4b38_8518_f130ead5e2d4
is encoded by: hsa:6901
is: Q16635
name: TAZ
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR SMS
is: SBO:0000176
reversible: false
reactant: MODEL1310110043#
name: Sphingomyelin synthase (homo sapiens)
type: Reaction
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.8.27
product: MODEL1310110043#
fast: false
is described by: ECO:0000269

metaM prostgh2 c
type: Species
is: CHEBI:57405
boundary condition: false
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: prostaglandin H2(1-)
constant: false
initial concentration: 1.0

metaR BALABETAtc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of beta alanine into the intestinal cells by beta transport system
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a05faa45_dcbc_4e83_8aa7_85e53a6a3021
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O95139
is encoded by: hsa:4712
name: NDUFB6
type: Species
constant: false
has only substance units: false
is: SBO:0000252

metaR C10CRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR r2389
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110043#

metaM ksi pre13 g
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 13
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: CHEBI:58053
type: Species
is: C00130

metaR UMPK3n
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110043#
reversible: true
name: UMP kinase (UTP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM ksi deg19 l
is: CHEBI:16953
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
is: SBO:0000247
initial amount: NaN
is: HMDB00812
name: keratan sulfate I, degradation product 19

metaM core4 g
constant: false
initial concentration: 1.0
name: Core 4
is: CHEBI:16478
is: SBO:0000247
notes: FORMULA: C24H40N3O15X CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaR GARFT
reversible: true
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
fast: false
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
name: phosphoribosylglycinamide formyltransferase
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_5c598492_6990_44e3_925b_b2ebaf777806
is encoded by: hsa:3030
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: HADHA
constant: false
has only substance units: false
is: E9KL44

metaR EX pydam LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxamine
type: Reaction

metaR FAOXC221C201x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_9bd061df_1c10_4f04_b508_3b3a9bbecfa6
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O75438
type: Species
is encoded by: hsa:4707
constant: false
name: NDUFB1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_0a5b8cea_3517_491c_9471_68ae0a957a27
type: Species
is encoded by: hsa:8395
initial concentration: NaN
has only substance units: false
name: PIP5K1B
is: SBO:0000252
initial amount: NaN
is: O14986
boundary condition: true
constant: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR r0660
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110043#
fast: false
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_85562006_5c8f_4b10_ada5_195147fc9334
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: SLC26A1
is encoded by: hsa:10861
type: Species
has only substance units: false
initial amount: NaN

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
modifier: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false

metaR O2tp
fast: false
name: O2 transport, peroxisomal
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM acgal g
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28037
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: N-acetyl-D-galactosamine

metaR NH4tp
name: ammonia peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#

metaM adp e
initial amount: NaN
initial concentration: 1.0
is: HMDB01341
constant: false
is: CHEBI:456216
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
has only substance units: false
is: SBO:0000247
name: ADP(3-)

metaM mhista c
is: SBO:0000247
initial concentration: 1.0
name: N(tele)-methylhistaminium
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00898
constant: false
boundary condition: false
is: CHEBI:58600

http://identifiers.org/biomodels.db/MODEL1310110043#_78a70920_5245_4e7f_9ae3_4f3d500465e9
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8706
is: Q49AT3
name: B3GALNT1
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_f214848b_d51b_4c9f_92e5_f531b6f1b660
constant: false
initial concentration: NaN
name: _AI915649_1_c
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI915649
has only substance units: false

metaR C2tcx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR DCSPTN1CPT1
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
name: carnitine O-palmitoyltransferase
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR THRASNNaEx
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110043#
fast: false
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110043#
is: SBO:0000185
type: Reaction

metaR 34HPLFM
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
name: 3-(4-hydroxyphenyl-)lactate formation
reversible: false
reactant: MODEL1310110043#

metaR PNTOte
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110043#
name: Transport of (R)-Pantothenate
reversible: true
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
fast: false

metaR r0661
fast: false
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110043#

metaM prostgh2 e
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
type: Species
is: HMDB01381
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin H2(1-)
is: CHEBI:57405
constant: false

metaM damp c
initial concentration: 1.0
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: SBO:0000247
is: HMDB00905
name: dAMP(2-)
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaR C4DCCACT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR GTHO
type: Reaction
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
is: SBO:0000176
is described by: ECO:0000254
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM hexe3coa m
constant: false
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 3-hexenoylcoa
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB06522

http://identifiers.org/biomodels.db/MODEL1310110043#_b81cdf01_f4d5_466f_8030_7db43f237136
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8TCG5
is: SBO:0000252
name: CPT1C
is encoded by: hsa:126129

http://identifiers.org/biomodels.db/MODEL1310110043#_aafcf6a4_149a_455a_a46f_836a218a0ca6
initial concentration: NaN
type: Species
name: CYP8B1
initial amount: NaN
is: Q9UNU6
has only substance units: false
is encoded by: hsa:1582
boundary condition: true
constant: false
is: SBO:0000252

metaM c4crn m
name: butyryl carnitine
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
is: C02862
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H21NO4 CHARGE: 0

metaM HC02187 c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28774
boundary condition: false
has only substance units: false
name: reverse-triiodthyronine

http://identifiers.org/biomodels.db/MODEL1310110043#_c1352edb_d66e_4c1c_b0ac_24916226402f
initial amount: NaN
name: HAL
is: B4E0V8
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3034
initial concentration: NaN
is: SBO:0000252

metaR DCSPTN1CPT2
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
modifier: MODEL1310110043#
reversible: false
name: carnitine transferase

metaM s7p c
has only substance units: false
is: HMDB01068
initial amount: NaN
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: C05382
initial concentration: 1.0
boundary condition: false
is: CHEBI:57483
type: Species
name: Sedoheptulose 7-phosphate
constant: false
is: SBO:0000247

metaM pchol hs r
is: CHEBI:16110
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Phosphatidylcholine
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false
initial amount: NaN

metaM ksi deg16 l
type: Species
name: keratan sulfate I, degradation product 16
is: SBO:0000247
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
is: HMDB00812
is: CHEBI:16953
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR PRGNLONEtr
reversible: true
name: pregnenolone intracellular transport
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110043#

metaR GTHP
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.11.1.15
name: glutathione peroxidase
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false
reversible: true
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD

metaR GALASE19ly
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is: SBO:0000176

metaR O2tm
reversible: true
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
type: Reaction
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
name: O2 transport (diffusion)
is described by: ECO:0000000

metaR DAG HSter
is: SBO:0000185
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: diacylglycerol ER export
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000000

metaM adp c
name: ADP
initial concentration: 1.0
is: C00008
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01341
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
is: SBO:0000247

metaM m8masn r
constant: false
has only substance units: false
type: Species
boundary condition: false
is: C05876
is: SBO:0000247
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0

metaR C162ACBP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR URIt5le
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: uridine transport in via sodium symport (1:2)
reversible: false
fast: false

metaM apoC Lys m
initial amount: NaN
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
name: Apocarboxylase (Lys residue)
initial concentration: 1.0
constant: false
is: HMDB00182
boundary condition: false
is: CHEBI:32551
is: SBO:0000247
type: Species

metaR DOLICHOL Uter
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
name: dolichol diffusion, human (uterus)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110043#

metaR C181OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM 2mb2coa m
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02054
name: 2-methylcrotonoyl-CoA(4-)
is: CHEBI:57337

metaR GGH 5THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
modifier: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
name: Gamma-glutamyl hydrolase (5THF), extracellular
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
type: Reaction

metaM abt e
type: Species
is: CHEBI:18403
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: L-arabinitol
initial amount: NaN
is: HMDB01851
constant: false

metaR FAOXC15ATPx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR CHAT
product: MODEL1310110043#
is: SBO:0000176
name: Choline O-acetyltransferase
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.6
reversible: true
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
type: Reaction

metaR DDECCRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8d57f84d_d4f4_42cc_8fd9_5c171cf9423a
type: Species
is: Q8NFF5
boundary condition: true
name: FLAD1
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:80308
is: SBO:0000252

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR PTRCOX1
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.3.21
reversible: false
name: Putrescine:oxygen oxidoreductase (deaminating)
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000304
fast: false
type: Reaction

metaM acald c
is: CHEBI:15343
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00990
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
name: acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110043#_e82bfe86_f77b_4e2e_a94f_06b882a91bad
initial amount: NaN
is: O14521
type: Species
has only substance units: false
is encoded by: hsa:6392
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SDHD

metaR S6TASE17ly
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#

metaM 10fthf m
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: CHEBI:57454

metaM r5p r
is: HMDB00618
boundary condition: false
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:18189
initial amount: NaN
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
has only substance units: false

metaR HBZOPT10m
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000176
name: Hydroxybenzoate Decaprenyltransferase
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.39
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_600175a1_bac7_4a14_b6f1_8d19093e1417
constant: false
is: P78330
initial amount: NaN
name: PSPH
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5723
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_71e862dd_996e_432c_aeea_ad0180662c6e
has only substance units: false
is: P05091
boundary condition: true
initial concentration: NaN
constant: false
name: ALDH2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:217

metaM chlstol r
boundary condition: false
is: CHEBI:16290
is: SBO:0000247
initial concentration: 1.0
name: 5alpha-cholesta-7,24-dien-3beta-ol
type: Species
is: HMDB06842
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439

metaM ptth c
initial concentration: 1.0
name: pantetheine
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
constant: false
type: Species

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM abt c
name: L-arabinitol
is: CHEBI:18403
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01851
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM 34dhmald c
is: http://identifiers.org/pubchem.compound/7903
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
initial amount: NaN
is: C05577
initial concentration: 1.0
is: HMDB06242
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_37a363af_092d_4883_afe5_9cb958f3d6d3
has only substance units: false
name: HMGCL
initial concentration: NaN
is encoded by: hsa:3155
is: Q6IBC0
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaR HISTAtu
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110043#
name: Histamine uniport
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9a964d95_1776_4136_9422_f7d4fa1c1c70
is encoded by: hsa:6575
type: Species
boundary condition: true
name: SLC20A2
is: B2RBR4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r0707
reversible: true
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.168
is described by: ECO:0000000
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_50e88caa_cbb5_4c26_ba51_fcf031dfd7e5
initial amount: NaN
name: SLC25A21
is: G3V4L5
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:89874
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_9afb2090_b880_4f80_8a16_cc259324aeb3
has part: Q9H3S5
type: Species
is: SBO:0000297
is encoded by: hsa:93183
initial concentration: NaN
has only substance units: false
name: PIGX:PIGM
has part: Q8TBF5
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:54965

metaR r1921
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Y+LAT2 Utilized transport
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM hom L e
boundary condition: false
name: L-homoserine
is: HMDB00719
initial amount: NaN
has only substance units: false
is: CHEBI:15699
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247

metaM acetone c
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
type: Species
is: SBO:0000247
name: acetone
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:15347
has only substance units: false

metaR NACHEX24ly
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
fast: false

metaR CHOLESTle
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.1.13
product: MODEL1310110043#
name: hydrolysis of cholesterol ester by cholesterol esterase

http://identifiers.org/biomodels.db/MODEL1310110043#_3d2b2a9c_768b_42cd_973a_1ca001bcd26e
initial concentration: NaN
is encoded by: hsa:8706
constant: false
is: O75752
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: B3GALNT1
initial amount: NaN

metaM lgnccoa x
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB06526
type: Species
is: SBO:0000247
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_fbd0e4ec_9e3f_4fdf_bbb1_b3ae5eecb9d4
is encoded by: hsa:728226
type: Species
name: _728226_1_m
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR TDCHOLAte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110043#
reactant: MODEL1310110043#
name: bile acid intracellular transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185

metaR r0706
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.10
fast: false
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X

http://identifiers.org/biomodels.db/MODEL1310110043#_59d4f3f1_d4d8_403c_92bf_01611378dc80
constant: false
has only substance units: false
is: D9HTE9
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6576
name: SLC25A1
type: Species
initial amount: NaN
initial concentration: NaN

metaM ctp e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: CTP(4-)
boundary condition: false
is: HMDB00082
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
is: CHEBI:37563

metaR PRGNLONEtm
name: pregnenolone intracellular transport
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR UREAtm
is described by: ECO:0000304
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Urea transport via diffusion
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_5b761271_737c_4e27_bd43_bd9ab6867cb9
constant: false
type: Species
is encoded by: hsa:4722
name: NDUFS3
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O75489
initial concentration: NaN

metaM ksi pre29 g
boundary condition: false
is: CHEBI:28067
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 29
has only substance units: false

metaM HC02205 e
name: prostaglandin-b2
is: CHEBI:28099
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
constant: false

metaR EX 3tdcrn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaM dadp n
name: dADP(3-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01508
has only substance units: false
constant: false
is: CHEBI:57667
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR r1607
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
reversible: true
product: MODEL1310110043#
type: Reaction

metaR PI45P3K
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110043#
reversible: false
is: SBO:0000176

metaM btcoa x
name: Butanoyl-CoA
constant: false
is: C00136
is: HMDB01088
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4

metaM ametam c
initial amount: NaN
is: C01137
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57443
name: S-Adenosylmethioninamine
type: Species
initial concentration: 1.0
is: HMDB00988

metaM gacpail hs r
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00128
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16344

http://identifiers.org/biomodels.db/MODEL1310110043#_3c4f4c97_49c3_4890_868d_0cb322c9bc24
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ESD
initial concentration: NaN
type: Species
constant: false
is: P10768
is encoded by: hsa:2098

http://identifiers.org/biomodels.db/MODEL1310110043#_3def58a9_3be4_4307_8794_2a0ccab9855b
name: PDE7B
type: Species
is: Q9NP56
initial amount: NaN
is encoded by: hsa:27115
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaR CERT2gt
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
name: ceramide transport protein
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaM ksi pre3 g
type: Species
constant: false
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 3
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
is: C00130
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_f9a1a133_0ca6_434e_8cb1_3a2b7aa54881
has only substance units: false
name: EARS2
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:124454
is: Q5JPH6
initial amount: NaN

metaM cspg e l
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
type: Species
has only substance units: false
is: CHEBI:36005
is: HMDB02183
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan

metaM apoC Lys c
name: Apocarboxylase (Lys residue)
notes: FORMULA: C6H13N2OX CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00182
is: SBO:0000247
constant: false
type: Species
is: CHEBI:32551
boundary condition: false

metaR EX tetdece1crn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaR r1608
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
is: SBO:0000185

metaR DIDPtn
is: SBO:0000185
name: dIDP nuclear transport
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
fast: false

metaM acgal l
is: HMDB00212
initial amount: NaN
name: N-acetyl-D-galactosamine
is: CHEBI:28037
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

http://identifiers.org/biomodels.db/MODEL1310110043#_a63dbecf_dc40_4f04_ba0d_011ce365e2e9
is encoded by: hsa:6487
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ST3GAL3
has only substance units: false

metaR GLCNACASE3ly
is described by: ECO:0000000
product: MODEL1310110043#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110043#
is: SBO:0000176
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.50

http://identifiers.org/biomodels.db/MODEL1310110043#_295d3e64_7d46_4938_baa1_67dbd005a41c
boundary condition: true
is encoded by: hsa:BE042354
has only substance units: false
initial concentration: NaN
constant: false
name: _BE042354_1_m
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_e4b21cc2_38b9_43aa_9658_f6125e933d77
constant: false
is: O00217
is encoded by: hsa:4728
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NDUFS8
is: SBO:0000252
type: Species

metaM ksi deg37 l
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
is: SBO:0000247
is: CHEBI:16953
constant: false
is: HMDB00812
initial amount: NaN
name: keratan sulfate I, degradation product 37
initial concentration: 1.0

metaM hs deg9 l
has only substance units: false
is: HMDB06355
type: Species
is: SBO:0000247
is: CHEBI:18268
name: heparan sulfate, degradation product 9
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
boundary condition: false
constant: false

metaM 3hbcoa R m
is: CHEBI:57315
constant: false
name: (R)-3-hydroxybutanoyl-CoA(4-)
type: Species
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
is: HMDB01166
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR PRPPS
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
name: phosphoribosylpyrophosphate synthetase
is described by: ECO:0000000
modifier: MODEL1310110043#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.6.1
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR FAOXC185C164m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaM mlthf m
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01533
initial concentration: 1.0
has only substance units: false
constant: false

metaR r1609
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110043#_10261213_d3bd_4984_854c_d80390544307
is encoded by: hsa:506
is: SBO:0000252
type: Species
is: P06576
boundary condition: true
name: ATP5B
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR NaKt
type: Reaction
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.6.3.9
fast: false
name: Na+/K+ exchanging ATPase
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
is described by: ECO:0000269
modifier: MODEL1310110043#
is: SBO:0000185

metaM dd5ecoa m
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
initial amount: NaN
is: C01942
is: HMDB13028
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: 5-dodecenoylcoa

metaR TDCHOLAtx
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reversible: true
name: bile acid intracellular transport
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_a8eff3e6_9abd_4409_8716_18301c3dba8b
has only substance units: false
initial amount: NaN
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
name: LDHC
type: Species
initial concentration: NaN
constant: false

metaR MALSO3tm
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
modifier: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
name: Malate:sulfite antiport, mitochondrial
product: MODEL1310110043#

metaR DCSPTN1COAtx
reversible: true
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185

metaM dadp m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
is: HMDB01508
has only substance units: false
name: dADP(3-)
is: CHEBI:57667
constant: false
type: Species

metaR FAOXC181C161x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR FUT17g
modifier: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69
name: Galactoside 2-alpha-L-fucosyltransferase 1
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ

metaR ATP2ter
kinetic law: MODEL1310110043#
name: AMP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110043#
is: SBO:0000185
fast: false
reactant: MODEL1310110043#

metaM octe5coa m
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
initial amount: NaN
name: 5-octenoylcoa
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0

metaR r0655
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaR DNDPt16m
fast: false
product: MODEL1310110043#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dUDP transport via dADP antiport
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#

metaR FATP2t
reactant: MODEL1310110043#
modifier: MODEL1310110043#
name: fatty acid electroneutral transport
is described by: ECO:0000269
type: Reaction
product: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185

metaM bhb m
constant: false
has only substance units: false
name: (R)-3-hydroxybutyrate
is: SBO:0000247
is: CHEBI:10983
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
initial concentration: 1.0
type: Species

metaR CYTK7n
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP,UTP),nuclear
reversible: true
fast: false

metaR PROSTGD2t
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
product: MODEL1310110043#

metaR ABO9g
is: SBO:0000176
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
is described by: ECO:0000269
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
reversible: false

metaM 3ohdcoa x
type: Species
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57349
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_439d8204_a0d2_4ef9_87da_35ba76add085
constant: false
is encoded by: hsa:10786
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: O00476
boundary condition: true
is: SBO:0000252
name: SLC17A3

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM 2oxoadp c
initial amount: NaN
name: 2-oxoadipate(2-)
initial concentration: 1.0
type: Species
is: HMDB00225
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM lnlncg e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:32391
initial amount: NaN
constant: false
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247
name: gamma-linolenate
type: Species

metaR GLCNACPT U
is: SBO:0000176
type: Reaction
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.8.15
fast: false
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110043#
reversible: false

metaR MM5ag
type: Reaction
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110043#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false

metaR r1603
product: MODEL1310110043#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_72a8fad5_982c_4a5f_b7a1_b64e13bc9ccd
is encoded by: hsa:9194
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q8NEM3
name: SLC16A7
initial concentration: NaN
has only substance units: false

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
modifier: MODEL1310110043#
is described by: ECO:0000269
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
type: Reaction
reversible: true
reactant: MODEL1310110043#

metaR PSERT
reversible: false
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.6.1.52
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
name: phosphoserine transaminase
fast: false
type: Reaction
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_da369536_2776_4565_a0f8_65279b4d148f
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI480132
constant: false
boundary condition: true
type: Species
name: _AI480132_1_c
initial concentration: NaN

metaR 1PPDCRp
reversible: false
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
name: delta1-piperideine-2-carboxylate reductase, perixosomal

http://identifiers.org/biomodels.db/MODEL1310110043#_0e59baad_a840_4c9b_a9fa_2bbaab04bc38
type: Species
boundary condition: true
is: P06865
constant: false
name: HEXA
is encoded by: hsa:3073
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r0653
kinetic law: MODEL1310110043#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_34884fa2_3a95_41f1_adae_0aac4a5d5c00
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI620219
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI620219_1_m

http://identifiers.org/biomodels.db/MODEL1310110043#_4b2b00b2_9baa_4f6a_bd58_b9721eab7715
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4548
type: Species
initial concentration: NaN
is: Q99707
initial amount: NaN
name: MTR
has only substance units: false
constant: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR RE3241R
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
name: RE3241
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110043#
type: Reaction

metaM pyr m
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
boundary condition: false
type: Species
name: pyruvate
is: CHEBI:15361
is: HMDB00243
is: C00022

metaM ump e
is: HMDB00288
name: UMP(2-)
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57865
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247

metaM lnlccoa r
initial concentration: 1.0
is: HMDB01064
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
name: linoleic coenzyme A
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false

metaR DGULND
name: dehydro-L-gulonate decarboxylase
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110043#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR TOLBUTAMIDEte
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
name: xenobiotic transport
product: MODEL1310110043#
fast: false
reversible: true

metaM CE5162 r
boundary condition: false
initial amount: NaN
name: trans,cis-2,9-octadecadienoyl-CoA
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
is: CHEBI:57923

metaR r1604
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaM 4hexdtricoa x
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02288
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247

metaR C14OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_0b2f4811_310b_4bdd_87fe_d53608652919
type: Species
name: NME1
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4830
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_5603018e_d05b_48a4_8e14_61cc69cd24b6
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q13615
name: MTMR3
is encoded by: hsa:8897
constant: false
is: SBO:0000252
boundary condition: true

metaR UGLCNACtg
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: UDP-GlcNAc Golgi transport via CMP antiport
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false
reactant: MODEL1310110043#

metaM triodthy e
is: CHEBI:18258
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00265
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
type: Species

metaR SERtN1
reversible: true
is described by: ECO:0000269
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Serine transport (Na, H coupled)
fast: false

metaR r0652
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
is described by: ECO:0000000
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR PGI
reactant: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.9
product: MODEL1310110043#
type: Reaction
name: glucose-6-phosphate isomerase
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110043#_2639533d_89f7_4812_af79_23206c72ba3e
is: O95169
name: NDUFB8
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:4714
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_652c01a8_c280_4d31_bb5b_7597742d7a1a
type: Species
name: INPP5J
initial amount: NaN
boundary condition: true
is encoded by: hsa:27124
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q15735
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d9abdb8d_3be5_4a16_987b_24671014d316
constant: false
has only substance units: false
type: Species
is: P43251
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: BTD
initial amount: NaN
is encoded by: hsa:686

metaR r1605
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: true
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC02187 e
initial amount: NaN
initial concentration: 1.0
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28774
constant: false
boundary condition: false

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_b688edef_2185_4bfe_a2cb_0fc313917413
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5211
initial amount: NaN
is: SBO:0000252
name: PFKL
is: Q7L2M7

metaM 4ppan c
name: D-4'-Phosphopantothenate
is: C03492
is: CHEBI:10986
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247
is: HMDB01016
constant: false
boundary condition: false
has only substance units: false

metaM xyl D c
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
initial concentration: 1.0
is: CHEBI:15936
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

metaR PGMT
is described by: ECO:0000134
name: phosphoglucomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
modifier: MODEL1310110043#
reversible: true
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_bae666c0_fd03_4f0d_9dab_4f62e40034b1
name: NDUFV3
is: SBO:0000252
constant: false
boundary condition: true
is: P56181
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4731
type: Species
has only substance units: false

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is described by: ECO:0000000
reversible: true
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110043#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f5228ae1_bde9_45a1_b98a_4bef80085e6f
is: P51648
name: ALDH3A2
initial concentration: NaN
is encoded by: hsa:224
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR ADPACDAc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR r1606
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#

metaR 5HOXINDACTO2OX
is version of: http://identifiers.org/ec-code/1.2.3.1
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000304
modifier: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
is: SBO:0000176
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

metaM ump c
type: Species
is: CHEBI:57865
name: UMP
is: HMDB00288
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
is: C00105
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d9fbf429_e870_4af6_95e8_b92ddfe678e8
boundary condition: true
name: SLC26A7
initial concentration: NaN
is encoded by: hsa:115111
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a782eb86_0895_4b08_9391_c7decd405674
initial amount: NaN
is: SBO:0000252
name: ATP5A1
boundary condition: true
is: A8K092
type: Species
is encoded by: hsa:498
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_67aa93fd_852e_4dfb_bef2_bd28921f4838
has only substance units: false
is: SBO:0000252
constant: false
is: O43426
is encoded by: hsa:8867
boundary condition: true
name: SYNJ1
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_9015057e_6787_49d8_86b1_aea9f743f862
constant: false
initial amount: NaN
name: NME1:NME2
is encoded by: hsa:4831
has part: P15531
type: Species
has part: P22392
is: SBO:0000297
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4830

metaM succoa c
name: Succinyl-CoA
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01022
initial amount: NaN
initial concentration: 1.0

metaM glx m
constant: false
initial amount: NaN
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
name: glyoxylate
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM succ x
type: Species
is: CHEBI:30031
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00254
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
name: Succinate
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_dbf2aba7_ce9e_4ece_9551_8f93d152fd22
is: SBO:0000252
constant: false
type: Species
name: MGAM
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8972
has only substance units: false
boundary condition: true
is: O43451

metaR SPMTDe
name: SPMTDe
reactant: MODEL1310110043#
fast: false
reversible: true
product: MODEL1310110043#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_438c9e90_8e74_4da2_8bb2_5cf5b4b30fb9
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
boundary condition: true
type: Species
is: P28329

metaM udp c
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: C00015
has only substance units: false
name: UDP
constant: false
boundary condition: false
is: CHEBI:58223
type: Species
is: HMDB00295
initial amount: NaN
initial concentration: 1.0

metaR GLYt7 311 r
modifier: MODEL1310110043#
fast: false
is: SBO:0000185
is described by: ECO:0000006
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (3:1:1)
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_189e0cc8_3bd6_48d0_bbc3_b1727eee8716
boundary condition: true
type: Species
name: MPST
initial amount: NaN
has only substance units: false
is encoded by: hsa:4357
constant: false
is: P25325
is: SBO:0000252
initial concentration: NaN

metaM 3hbcoa R c
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01166
name: (R)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0

metaR GLACter
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
reversible: true
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
product: MODEL1310110043#
is: SBO:0000185

metaM 3ohdcoa m
constant: false
type: Species
initial amount: NaN
is: HMDB06402
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349

http://identifiers.org/biomodels.db/MODEL1310110043#_3ce0810b_91d1_45b2_af5b_1e70e5869e8c
is: O43677
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4717
has only substance units: false
name: NDUFC1
type: Species
initial amount: NaN
boundary condition: true

metaR DESAT22 2p
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
type: Reaction

metaR NDP7er
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
product: MODEL1310110043#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_eb596423_c258_44e8_aae2_a4021e80d430
boundary condition: true
has part: O15270
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:10558
type: Species
is encoded by: hsa:9517
initial concentration: NaN
is: SBO:0000297
has part: O15269
name: SPTLC1:SPTLC2

metaR r0226
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
product: MODEL1310110043#
fast: false
reversible: false
type: Reaction
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_aa0993e7_f78b_4f17_93ae_27ab88536918
boundary condition: true
constant: false
is encoded by: hsa:11332
type: Species
has only substance units: false
name: ACOT7
is: SBO:0000252
initial amount: NaN
is: O00154
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_5bf2d1fa_4cb3_4cdc_b86a_bf165df99930
name: _HG2846_HT2983_1_c
has only substance units: false
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true

metaM bhb e
constant: false
has only substance units: false
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
boundary condition: false
initial concentration: 1.0
is: HMDB00011
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species

metaR r0545
is described by: ECO:0000000
fast: false
modifier: MODEL1310110043#
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110043#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
kinetic law: MODEL1310110043#

metaR r1823
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110043#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

metaR ADRNCPT2
name: carnitine transferase
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110043#
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110043#

metaR C162OHe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_4832f80c_cfae_4357_8f1d_f8684fb6dde4
type: Species
boundary condition: true
initial amount: NaN
name: TM7SF2
is: SBO:0000252
constant: false
is: O76062
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7108

metaR r1600
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110043#

metaM 34dhoxmand m
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 3,4-Dihydroxymandelate
has only substance units: false
boundary condition: false
is: HMDB01866

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: CHEBI:31997
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: Phosphodimethylethanolamine
boundary condition: false
constant: false
initial concentration: 1.0

metaM ile L m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: CHEBI:17191
is: HMDB00172
type: Species
name: L-isoleucine

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_99d58bb8_1603_4ad9_8647_c65b202f8208
initial concentration: NaN
name: SGPL1
constant: false
boundary condition: true
is: O95470
is encoded by: hsa:8879
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaM udp e
constant: false
name: UDP(3-)
is: CHEBI:58223
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: SBO:0000247

metaR ACACt2
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
name: acetoacetate transport via proton symport
reactant: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110043#
reversible: true

metaM udpacgal l
initial amount: NaN
is: HMDB00304
has only substance units: false
is: SBO:0000247
is: CHEBI:57847
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_5d426cdf_579c_4e11_8eb2_37fab8d14b86
boundary condition: true
type: Species
initial concentration: NaN
name: PYCR1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5831
constant: false
has only substance units: false
is: A6NFM2

metaR LNLNCGCRNt
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_4d985304_bd53_4914_96f7_9e41fce6d236
is encoded by: hsa:64841
constant: false
has only substance units: false
is: SBO:0000252
name: GNPNAT1
is: Q96EK6
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species

metaR LCAT1e
is version of: http://identifiers.org/ec-code/2.3.1.43
is described by: ECO:0000000
name: Lecithin-cholesterol acyltransferase
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (3931.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.43 Confidence Level: 4 AUTHORS: PMID:11435418,PMID:11966470 NOTES:NJ
type: Reaction
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176

metaM cspg e e
constant: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: CHEBI:16040
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00630

metaM bhb c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: CHEBI:10983
is: HMDB00011
boundary condition: false
initial amount: NaN
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

http://identifiers.org/biomodels.db/MODEL1310110043#_e3daea4e_1fc2_4549_9c9d_186a03eff7ca
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:93183
is: Q9H3S5
name: PIGM
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR r1821
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#

metaM lnlncg c
is: HMDB03073
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
name: gamma-linolenate
boundary condition: false
is: CHEBI:32391
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM lnlncacoa m
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: CHEBI:51985
name: alpha-Linolenoyl-CoA
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06290

metaR r0853
name: Facilitated diffusion
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185

metaR C162OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaM uri e
name: Uridine
type: Species
boundary condition: false
has only substance units: false
is: HMDB00296
is: CHEBI:16704
is: C00299
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_bdc4096a_06c8_4f78_8a34_9e96840204b9
name: _C7orf24_1_m
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:C7orf24

http://identifiers.org/biomodels.db/MODEL1310110043#_3d828af4_99fd_4411_89ee_caf6015d4553
is encoded by: hsa:498
is: P25705
name: ATP5A1
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d046a4a4_f1c8_4c43_9062_3b89745f905c
has only substance units: false
type: Species
boundary condition: true
is: Q9BY07
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:57835
name: SLC4A5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_b6322042_cde2_4962_b4c0_da5aac4aeb8e
initial concentration: NaN
has only substance units: false
is: Q5SPY7
name: ENTPD2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:954
type: Species
initial amount: NaN

metaR r1602
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110043#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110043#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_43143327_53d0_4120_ad5e_61bca1d69c93
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: HEXB
is: SBO:0000252
is: P07686
is encoded by: hsa:3074

metaM ump g
constant: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
name: UMP(2-)
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57865
initial concentration: 1.0
has only substance units: false

metaR ESTSULT
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000269
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.4
type: Reaction
name: Estrogen sulfotransferase
notes: GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES:NJ

metaM udp g
is: CHEBI:58223
boundary condition: false
constant: false
name: UDP(3-)
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
initial concentration: 1.0
is: HMDB00295

http://identifiers.org/biomodels.db/MODEL1310110043#_1b98c21f_071f_4e50_a195_fa5ac35107e3
is encoded by: hsa:R14373
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _R14373_1_x

http://identifiers.org/biomodels.db/MODEL1310110043#_389d4314_5f64_448c_8573_203240bdd398
initial concentration: NaN
is: SBO:0000252
is: P20594
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: NPR2
is encoded by: hsa:4882

http://identifiers.org/biomodels.db/MODEL1310110043#_7981928e_ed92_4f74_92b4_afb98df3985a
is encoded by: hsa:6580
is: SBO:0000252
boundary condition: true
is: O15245
name: SLC22A1
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR RTOTALFATPc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR FAOXTC122TC101m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM CE5586 c
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
initial amount: NaN
constant: false
is: CHEBI:58732
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586

http://identifiers.org/biomodels.db/MODEL1310110043#_632f7315_7886_489a_bc5e_3269ec1515af
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4706
name: NDUFAB1
is: SBO:0000252
initial concentration: NaN
is: O14561
constant: false
type: Species

metaR SUCCt4 2
product: MODEL1310110043#
is described by: ECO:0000269
name: succinate transport via sodium symport
fast: false
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: true
modifier: MODEL1310110043#
reactant: MODEL1310110043#

metaR AG13T7g
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110043#
reversible: false
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000

metaM ump n
type: Species
is: SBO:0000247
is: HMDB00288
is: CHEBI:57865
boundary condition: false
constant: false
has only substance units: false
name: UMP(2-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR DLNLCGt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
name: fatty acid transport via diffusion

metaR r0549
kinetic law: MODEL1310110043#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.5.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is version of: http://identifiers.org/ec-code/1.6.99.3
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17

metaM uri c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: Uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
is: C00299
has only substance units: false
is: HMDB00296
type: Species

metaM glx x
has only substance units: false
is: CHEBI:36655
initial amount: NaN
is: HMDB00119
constant: false
boundary condition: false
initial concentration: 1.0
name: glyoxylate
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
type: Species

metaR FAOXC11
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110043#
reversible: false
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_50b94a12_3eb5_4033_ba47_f208fd31bc1c
is: P48728
constant: false
is encoded by: hsa:275
initial amount: NaN
type: Species
name: AMT
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_88cab070_8dcb_4669_a5d7_7979ccd4b3b8
has only substance units: false
name: _H77542_1_c
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:H77542

metaM pyr e
boundary condition: false
constant: false
is: CHEBI:15361
has only substance units: false
name: pyruvate
initial concentration: 1.0
is: HMDB00243
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaR DECCRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_e1efbc65_a45a_4eb8_921d_c4d4300df02c
is encoded by: hsa:158
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P30566
boundary condition: true
name: ADSL

http://identifiers.org/biomodels.db/MODEL1310110043#_ecd80e97_f419_4a5b_9e84_189453910469
initial concentration: NaN
is encoded by: hsa:9061
type: Species
constant: false
is: SBO:0000252
is: O43252
name: PAPSS1
initial amount: NaN
has only substance units: false
boundary condition: true

metaR APOCFm
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: Apocarboxylase formation, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110043#
type: Reaction
reversible: false
fast: false

metaR BPNT
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.7
name: 3',5'-bisphosphate nucleotidase
product: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_797c9e34_1e60_4263_952b_33a8cb779bd9
name: NT5M
initial concentration: NaN
is encoded by: hsa:56953
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: Q9NPB1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_751f12bc_4ea0_4f06_a111_a3579ebe0a6a
initial concentration: NaN
name: BDH1
is encoded by: hsa:622
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: Q02338
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_f3999d4b_8229_463a_96b3_c839f4147be9
name: SLC23A2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9962
is: Q9UGH3
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaR r0321
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
fast: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.3.5.2
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is described by: ECO:0000000

metaR SUCCt2m
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000269
name: succinate transport, mitochondrial
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_f357b867_854c_41a4_a1b9_d2d754359f26
is: F5H6D0
initial concentration: NaN
is encoded by: hsa:7841
has only substance units: false
name: MOGS
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_b32ad013_d80f_46e4_a659_7c18bba181a6
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:570
is: SBO:0000252
is: Q14032
has only substance units: false
boundary condition: true
type: Species
name: BAAT

http://identifiers.org/biomodels.db/MODEL1310110043#_8a03e65c_4628_43bc_b99a_a19b3888aeed
is encoded by: hsa:11136
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: SLC7A9
type: Species
initial concentration: NaN
is: SBO:0000252
is: P82251

http://identifiers.org/biomodels.db/MODEL1310110043#_04cf5805_b3dd_4e22_81c8_16e4218a8878
initial amount: NaN
constant: false
is: E7ETH5
name: SLC13A2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9058
boundary condition: true
type: Species

metaR NBAHH ir
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.13.20
product: MODEL1310110043#
fast: false
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110043#

metaR HEX1
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucose:ATP)
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110043#
is described by: ECO:0000134

metaM C02528 c
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
boundary condition: false
is: CHEBI:36234
is: HMDB00518
name: chenodeoxycholate
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaM c4crn x
is: SBO:0000247
is: HMDB02013
constant: false
is: C02862
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine

http://identifiers.org/biomodels.db/MODEL1310110043#_5d1be812_7e00_4e94_a2e0_57e5e84acb1b
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: HSD11B1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3290
is: P28845

metaM pyr c
is: SBO:0000247
boundary condition: false
has only substance units: false
name: pyruvate
initial concentration: 1.0
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
is: C00022
is: HMDB00243
initial amount: NaN
type: Species

metaR ADRNCPT1
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
reversible: false
name: carnitine O-palmitoyltransferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM omhdecacid c
initial concentration: 1.0
notes: FORMULA: C10H19O3 CHARGE: -1
boundary condition: false
is: HMDB00672
type: Species
is: SBO:0000247
has only substance units: false
name: w-hydroxydecanoicacid
constant: false
is: C08260
initial amount: NaN

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR r0009
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
fast: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000134
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
fast: false
type: Reaction
reversible: true
name: PTPATe

metaM HC02204 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:27624
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_81146d6d_6d3a_494b_ad35_f48a56d7886f
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9Y5L3
name: ENTPD2
boundary condition: true
is encoded by: hsa:954

metaM hs deg12 l
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 12
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB01352
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
is: CHEBI:17180
has only substance units: false

metaM g3m8mpdol U r
is: SBO:0000247
has only substance units: false
is: C05873
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b8d83ea0_3bd0_4ea1_a685_d2df1110abbf
is: SBO:0000252
is: Q6LEN5
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:1103
name: CHAT
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_062e5752_4e80_41b1_84db_1b48e27b9318
is: SBO:0000252
is encoded by: hsa:2194
initial amount: NaN
initial concentration: NaN
type: Species
is: P49327
boundary condition: true
name: FASN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_33e155e9_a242_409c_b59a_0333534f1314
boundary condition: true
name: PDE9A
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5152
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR C180CPT2
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: carnitine O-stearoyl transferase
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_0fe6bb6c_5667_41f3_87fb_b0f503a18949
constant: false
name: B4GALT2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:8704
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM 3hpcoa m
boundary condition: false
is: HMDB06807
is: CHEBI:58528
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: 3-hydroxypropanoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668

http://identifiers.org/biomodels.db/MODEL1310110043#_bbf41e06_41ef_4c73_a190_86a79d470d78
initial concentration: NaN
is: O95622
constant: false
initial amount: NaN
is encoded by: hsa:111
name: ADCY5
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR S6TASE16ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: true
fast: false
reactant: MODEL1310110043#
type: Reaction

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR GGH 10FTHF6GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction

metaM uri n
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: uridine
is: CHEBI:16704
has only substance units: false
constant: false
is: HMDB00296

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM stcoa m
boundary condition: false
type: Species
is: HMDB01114
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN
is: CHEBI:57394
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412

metaM glutcoa m
is: HMDB01339
has only substance units: false
name: glutaryl-CoA(5-)
constant: false
initial concentration: 1.0
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial amount: NaN
is: CHEBI:57378
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_7d3c8428_9250_4874_8766_a379468e69b2
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:482
constant: false
is: SBO:0000297
name: ATP1A3:ATP1B2
has only substance units: false
has part: P14415
initial concentration: NaN

metaM dece4coa m
type: Species
initial concentration: 1.0
has only substance units: false
name: 4-decenoylcoa
boundary condition: false
is: HMDB02145
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM CE2916 e
notes: FORMULA: C35H51N6O10 CHARGE: -1 INCHI: InChI=1/C35H52N6O10/c1-5-20(4)29(35(50)51)39-31(46)26-9-7-17-41(26)34(49)24(14-15-27(43)44)37-32(47)28(19(2)3)38-30(45)25-8-6-16-40(25)33(48)23(36)18-21-10-12-22(42)13-11-21/h10-13,19-20,23-26,28-29,42H,5-9,14-18,36H2,1-4H3,(H,37,47)(H,38,45)(H,39,46)(H,43,44)(H,50,51)/p-1/t20-,23+,24+,25+,26+,28-,29-/m0/s1 EHMN_ABBREVIATION: CE2916
boundary condition: false
has only substance units: false
type: Species
name: neocasomorphin
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
initial concentration: 1.0
is: C01936
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a52c4540_6ef0_47ed_9403_9a9de2dbafa6
type: Species
is: Q9C0J1
is encoded by: hsa:79369
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: B3GNT4

http://identifiers.org/biomodels.db/MODEL1310110043#_201dbc79_0734_4c91_8210_304343012b84
initial amount: NaN
is encoded by: hsa:2977
has only substance units: false
is: P33402
constant: false
initial concentration: NaN
type: Species
name: GUCY1A2
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_8dda7baa_3b8c_46ae_bf6e_09f9ffa0a07b
constant: false
type: Species
initial concentration: NaN
is: Q3KQV9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:91373
name: UAP1L1
has only substance units: false
boundary condition: true

metaR RE0830N
modifier: MODEL1310110043#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE0830
reactant: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_88f150a7_f8ca_4311_9481_d4975f58d250
constant: false
is encoded by: hsa:55907
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CMAS
initial amount: NaN
is: Q8NFW8

http://identifiers.org/biomodels.db/MODEL1310110043#_73ac30ae_a31e_4d45_a8a6_0a45e7337017
is: O60825
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: PFKFB2
boundary condition: true
is encoded by: hsa:5208
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_6716d66c_66d1_4cc3_95c2_bb50aa870688
is: SBO:0000252
initial concentration: NaN
name: SLC25A26
is: Q70HW3
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:115286

http://identifiers.org/biomodels.db/MODEL1310110043#_1ce6f880_6d1b_4bb2_9788_9ab07ee432a1
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: P38117
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2109
name: ETFB
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_17fbd9fb_ab3e_44b2_8f07_58889364e7f0
name: NSDHL
is: Q15738
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:50814
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaR NADPtru
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
name: NADP transporter, endoplasmic reticulum

metaM lnlccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
constant: false
name: linoleic coenzyme A
has only substance units: false
is: HMDB01064
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_78d53f40_0828_4868_8950_c8511029d9fa
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:30814
is: Q9NZK7
initial amount: NaN
name: PLA2G2E

http://identifiers.org/biomodels.db/MODEL1310110043#_0c6ee037_bd41_4831_98d0_90813db5b809
boundary condition: true
name: ENTPD3
is encoded by: hsa:956
is: O75355
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

metaM 2oxoadp m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 2-oxoadipate(2-)
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
has only substance units: false
is: CHEBI:57499
constant: false

metaR INSTt4 2
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
modifier: MODEL1310110043#
fast: false
is: SBO:0000185
name: inositol transport via sodium symport
type: Reaction

metaR C141OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_c7e2e62d_5479_4400_9c4a_e0f4ed7bafbc
initial concentration: NaN
has only substance units: false
name: NDUFA13
constant: false
is: Q9P0J0
initial amount: NaN
is encoded by: hsa:51079
boundary condition: true
type: Species
is: SBO:0000252

metaM udpacgal c
boundary condition: false
is: HMDB00304
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
type: Species
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: CHEBI:57847

metaM lgnc e
type: Species
is: HMDB02003
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
boundary condition: false
is: CHEBI:31014
initial concentration: 1.0
name: lignocerate

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR C180CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110043#
name: production of stearoylcarnitine
type: Reaction
product: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
fast: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2e6627fe_310d_4167_9449_d60ee659e026
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:953
boundary condition: true
constant: false
name: ENTPD1
initial amount: NaN
is: Q86VV3
has only substance units: false

metaR G14T6g
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
modifier: MODEL1310110043#

metaR DMHPTCRNte
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
product: MODEL1310110043#
reversible: true
is: SBO:0000185
name: 2,6 dimethylheptanoyl carnitine transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_86a712ad_1834_46db_9075_9873b74d3b83
is encoded by: hsa:4882
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NPR2
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR DUMPtn
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110043#
name: dUMP nuclear transport
product: MODEL1310110043#

metaR EX htaxol LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated taxol exchange
type: Reaction

metaR S23T3g
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.6
kinetic law: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_80b07a95_19f1_4f93_bec4_cad0c6d82d43
has only substance units: false
name: NMNAT2
is encoded by: hsa:23057
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8ea146b3_58d4_431e_b076_c0470f59d239
boundary condition: true
type: Species
is encoded by: hsa:56922
constant: false
is encoded by: hsa:64087
has part: Q9HCC0
has only substance units: false
name: MCCC1:MCCC2
initial concentration: NaN
has part: Q96RQ3
is: SBO:0000297
initial amount: NaN

metaR NACHEX10ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110043#
fast: false
reversible: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_86d77535_c694_456a_865b_322a3ffaa73a
is encoded by: hsa:4712
boundary condition: true
is encoded by: hsa:4731
has part: Q5VYT2
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is: SBO:0000297

metaM ksi pre31 g
is: C00130
name: keratan sulfate I biosynthesis, precursor 31
is: HMDB00175
type: Species
initial amount: NaN
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58053
boundary condition: false
has only substance units: false

metaM hpyr c
initial amount: NaN
is: CHEBI:17180
has only substance units: false
type: Species
is: HMDB01352
name: 3-hydroxypyruvate
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168

metaR ORNt4m
reversible: true
name: ornithine mitochondrial transport exchange with citruline
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
fast: false

metaR NACHEX25ly
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#

metaR r0541
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110043#
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
modifier: MODEL1310110043#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:

metaM lgnc c
is: HMDB02003
type: Species
constant: false
is: SBO:0000247
is: CHEBI:31014
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: lignocerate
has only substance units: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547

http://identifiers.org/biomodels.db/MODEL1310110043#_8754372b_7eb3_44e6_b476_748f398074a8
is: B2RAU6
name: PIGQ
constant: false
initial amount: NaN
is encoded by: hsa:9091
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM gthrd c
is: C00051
boundary condition: false
constant: false
is: CHEBI:57925
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00125
name: Reduced glutathione

metaM 17ahprgnlone r
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:28750
name: 17alpha-hydroxypregnenolone
has only substance units: false
initial amount: NaN
is: HMDB00363
notes: FORMULA: C21H32O3 CHARGE: 0 INCHI: InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C05138
initial concentration: 1.0

metaM elaid c
has only substance units: false
is: SBO:0000247
is: CHEBI:30825
type: Species
initial concentration: 1.0
name: elaidate
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
constant: false
is: HMDB00573

metaR 3SALAASPm
is: SBO:0000185
name: cysteinesulfinate-aspartate mitochondrial shuttle
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true

metaM c10dc c
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00651
constant: false
name: sebacoyl carnitine
initial amount: NaN
notes: FORMULA: C17H30NO6 CHARGE: -1

metaM pail4p hs c
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58178

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaM gudac c
name: guanidinoacetic acid
initial concentration: 1.0
is: CHEBI:16344
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
boundary condition: false
is: SBO:0000247
is: HMDB00128
has only substance units: false

metaM HC01180 c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
initial amount: NaN
type: Species
is: CHEBI:58694
constant: false
has only substance units: false
name: D-tagatofuranose 1,6-bisphosphate(4-)
initial concentration: 1.0

metaR PEt
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
fast: false
kinetic law: MODEL1310110043#
name: phosphatidylethanolamine transport
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:

metaM gchola e
initial amount: NaN
initial concentration: 1.0
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0
has only substance units: false
type: Species
name: glycocholate
is: SBO:0000247
boundary condition: false
constant: false

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_26b6a54a_b120_4001_9ef7_f4583ff0be8f
is: SBO:0000252
name: ESPN
initial amount: NaN
constant: false
has only substance units: false
is: B1AK53
boundary condition: true
type: Species
is encoded by: hsa:83715
initial concentration: NaN

metaR CYSGLUexR
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
name: L-cysteine/L-glutamine reversible exchanger
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110043#
reversible: true

metaR C10DCc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_c94c6f6c_26ef_4612_ad58_8e2d17c46ca4
is: SBO:0000252
boundary condition: true
is: O94777
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:8818
initial concentration: NaN
type: Species
name: DPM2

metaR RE0344C
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000176
reversible: true
product: MODEL1310110043#
name: RE0344
is described by: ECO:0000000

metaR S6T16g
fast: false
reversible: false
product: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110043#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110043#

metaR CSPG Etly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: chondroitin sulfate E transport, extracellular to lysosome
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_0f6b701e_64ed_437e_ad48_f2f74967710a
initial concentration: NaN
name: _AI694761_1_c
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI694761
constant: false
is: SBO:0000252
initial amount: NaN

metaM HC02204 c
has only substance units: false
initial concentration: 1.0
is: CHEBI:27624
name: prostaglandin-b1
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_fe5742d9_0fd0_4921_bd5f_36ab3b92d7e9
initial concentration: NaN
initial amount: NaN
type: Species
name: AICDA
is: Q546Y9
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:57379
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ef260ce9_fd3a_4d9e_bec9_558c45178605
is: Q5T6L4
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: ASS1
is encoded by: hsa:445
boundary condition: true
is: SBO:0000252
type: Species

metaR ACGALK2
is: SBO:0000176
reversible: false
name: N-acetylgalactosamine kinase (ITP)
fast: false
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM amp x
is: C00020
name: AMP
boundary condition: false
is: CHEBI:456215
is: HMDB00045
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
initial concentration: 1.0

metaM acgpail hs c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57265
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288

metaM ksi deg15 l
is: SBO:0000247
initial amount: NaN
is: HMDB00143
constant: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: CHEBI:12936
has only substance units: false
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 15
boundary condition: false

metaR FAOXC2051843m
product: MODEL1310110043#
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
name: Beta oxidation of fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110043#

metaM elaid e
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: CHEBI:30825
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: elaidate
constant: false
is: HMDB00573
boundary condition: false

metaM cdpea c
is: SBO:0000247
name: cdpea[c]
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57876
boundary condition: false
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
type: Species
is: HMDB01564
constant: false

metaM gthrd e
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
is: CHEBI:57925
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00125
initial concentration: 1.0
has only substance units: false
name: glutathionate(1-)

metaM udpacgal g
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
is: CHEBI:57847
is: SBO:0000247
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_53bd99c0_9eb5_4430_8fe3_ad1e1a419f56
is encoded by: hsa:79087
boundary condition: true
is: SBO:0000252
name: ALG12
is: Q9BV10
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
initial amount: NaN
is: CHEBI:26174
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
name: nLc7Cer
has only substance units: false

metaM ksi deg4 l
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
has only substance units: false
constant: false
boundary condition: false
is: HMDB00868
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57737
name: keratan sulfate I, degradation product 4
type: Species

metaR r0002
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_0ae36d57_0586_44fe_a78e_b00be888ddf9
is encoded by: hsa:248
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: P09923
name: ALPI

metaR UGALGTg
type: Reaction
fast: false
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD

metaM ksii core4 pre9 g
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:28067
constant: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 9
type: Species

metaR RE3624M
type: Reaction
modifier: MODEL1310110043#
name: RE3624
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reversible: false

metaM gchola c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: SBO:0000247
is: CHEBI:58235
is: HMDB00138
constant: false
has only substance units: false
name: glycocholate

metaM glx c
constant: false
initial amount: NaN
boundary condition: false
name: glyoxylate
is: HMDB00119
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
type: Species

metaM octe5coa x
initial amount: NaN
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5-octenoylcoa
type: Species

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2b3ea56e_a832_413a_b12a_e2e85194fe0d
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:230
boundary condition: true
initial amount: NaN
name: ALDOC
is: P09972
initial concentration: NaN
has only substance units: false

metaR DNDPt38m
reversible: false
modifier: MODEL1310110043#
fast: false
name: dUTP transport via dUDP antiport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
is described by: ECO:0000269
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_b006cbd8_9257_40a8_a974_5617373ab6a1
name: QPRT
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q15274
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23475

http://identifiers.org/biomodels.db/MODEL1310110043#_b0fc14cd_5b0e_42c0_adf5_32ac20ca59bb
is encoded by: hsa:6820
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: SULT2B1
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR GLCter
name: glucose transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110043#

metaR NAt3 1
reversible: true
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
name: sodium proton antiporter (H:NA is 1:1)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_94926944_2292_4221_93ad_1701ebe8a00d
initial amount: NaN
is: SBO:0000252
name: COX3
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4514
has only substance units: false
is: P00414
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_1b6b07c5_04bf_4b39_9f51_a32d52fc855c
is: P13073
constant: false
is encoded by: hsa:1327
is: SBO:0000252
name: COX4I1
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR r0650
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_8479ec8a_591c_4009_a53c_a687f4511a91
is encoded by: hsa:115286
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC25A26
initial amount: NaN
constant: false
is: F8WAB8
is: SBO:0000252

metaM tststerone e
name: testosterone
is: HMDB00234
boundary condition: false
is: CHEBI:17347
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaM mlthf c
is: HMDB01533
is: C00143
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species
has only substance units: false
is: CHEBI:15636
boundary condition: false
initial concentration: 1.0
constant: false

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR F1PGT
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110043#
name: fucose-1-phosphate guanylyltransferase
is described by: ECO:0000000
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.7.30
is: SBO:0000176
fast: false

metaR SARCStex
reversible: false
is described by: ECO:0000000
name: Sarcosine transport (extracellular to cytosol)
type: Reaction
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
reversible: true
name: blood group intracellular transport
is: SBO:0000185
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

metaM 3ivcrn c
boundary condition: false
initial concentration: 1.0
name: 3-hydroxy-isovaleryl carnitine
is: HMDB06870
has only substance units: false
initial amount: NaN
notes: FORMULA: C12H23NO5 CHARGE: 0
is: C05998
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247

metaM 4hexdtricoa m
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: 4,7,10-hexadecatrienoylcoa
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM 4aphdob c
is: CHEBI:58147
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00978
constant: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_9512c11d_17d3_4458_87e5_faa7d7034188
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:376497
is: Q6PCB7
boundary condition: true
name: SLC27A1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_73802073_5133_45ea_b728_7f3b8b85a0bc
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q5BKT4
initial concentration: NaN
name: ALG10
is encoded by: hsa:84920
constant: false
has only substance units: false
type: Species

metaM ksi pre12 g
constant: false
is: HMDB00175
is: CHEBI:58053
has only substance units: false
is: C00130
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 12
type: Species

metaR G14T19g
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is described by: ECO:0000000
type: Reaction

metaR VALt5m
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Valine reversible mitochondrial transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ba70afec_ed8f_4e74_bc61_ac499f67f936
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51703
is: Q9ULC5
name: ACSL5
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM triodthy c
is: CHEBI:18258
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: HMDB00265
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
constant: false
type: Species
boundary condition: false
initial amount: NaN

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM 5htrp c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:17780
is: HMDB00472
type: Species
constant: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
name: 5-hydroxy-L-tryptophan
initial concentration: 1.0
initial amount: NaN

metaM guln r
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
name: L-gulonate
type: Species
initial amount: NaN
is: CHEBI:13115
constant: false
is: SBO:0000247
is: HMDB03290

metaR DHPM1
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.2.2
fast: false
is described by: ECO:0000269
product: MODEL1310110043#
name: dihydropyrimidinase (5,6-dihydrouracil)
reactant: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#

metaR r0437
reversible: true
product: MODEL1310110043#
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR RE0830C
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
name: RE0830
reversible: true

metaR ACNMLr
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: N-Acetylneuraminate lyase (reversible)
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false

metaM pail5p hs n
initial amount: NaN
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false

metaM glutcoa c
constant: false
initial amount: NaN
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01339

metaR PFK
is version of: http://identifiers.org/ec-code/2.7.1.11
fast: false
reversible: false
type: Reaction
name: phosphofructokinase
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176

metaM dece4coa x
is: HMDB02145
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: 4-decenoylcoa
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_a5cf7c81_db50_40ef_8c5b_7e8b1b09235f
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: LDHA
is: P00338
initial concentration: NaN
is encoded by: hsa:3939
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_cc030bea_8dd8_4c6a_a6ff_a3564b709645
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _AI761708_1_m
is encoded by: hsa:AI761708
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_28416c59_b9a2_4fe8_bf3d_79b9da380a13
type: Species
boundary condition: true
is: SBO:0000252
name: NDUFB8
constant: false
has only substance units: false
is encoded by: hsa:4714
initial amount: NaN
is: O95169
initial concentration: NaN

metaR ASPPROASCT1
reactant: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
product: MODEL1310110043#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
fast: false
name: aspartate intake by system ASCT-1 transporter
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110043#
fast: false
reversible: true
is: SBO:0000185
name: blood group intracellular transport
reactant: MODEL1310110043#
is described by: ECO:0000000

metaR r0119
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110043#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
type: Reaction
is described by: ECO:0000000

metaM 3ivcrn e
has only substance units: false
constant: false
notes: FORMULA: C12H23NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: 3-hydroxy-isovaleryl carnitine
is: HMDB13336
boundary condition: false

metaM lnlccoa m
has only substance units: false
name: linoleic coenzyme A
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
initial amount: NaN
initial concentration: 1.0
constant: false

metaR C9BRxtc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaM tststerone c
initial concentration: 1.0
is: HMDB00234
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species

metaM fmn c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00061
has only substance units: false
initial amount: NaN
name: FMN
is: HMDB01520
is: CHEBI:58210
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
type: Species

metaR r1934
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reversible: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Y+LAT2 Utilized transport

metaR FAOXC2051843x
is described by: ECO:0000269
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110043#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR DHPM2
name: dihydropyrimidinase (dihydrothymine)
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
reversible: false

metaR RE1804M
reactant: MODEL1310110043#
name: RE1804
fast: false
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000

metaR GTHOm
product: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
name: glutathione oxidoreductase
is: SBO:0000176
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
fast: false
is described by: ECO:0000254

metaR FATP3t
is described by: ECO:0000269
fast: false
name: fatty acid electroneutral transport
kinetic law: MODEL1310110043#
reversible: true
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110043#
is: SBO:0000185

metaR UMPK4n
reversible: true
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaM dadp c
boundary condition: false
is: HMDB01508
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
initial concentration: 1.0
name: dADP
is: C00206
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_208a95b6_e407_4161_9bed_fd65f2adde93
is encoded by: hsa:50940
initial amount: NaN
is: Q9HCR9
is: SBO:0000252
name: PDE11A
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r1078
name: Vesicular transport
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185

metaM glysar e
is: http://identifiers.org/pubchem.compound/93131
has only substance units: false
name: Glycylsarcosine
notes: FORMULA: C5H10N2O3 CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

metaR C4tmc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_e7804337_5a56_4c26_ae7d_857db0e34676
name: GLB1
constant: false
boundary condition: true
initial concentration: NaN
is: P16278
type: Species
initial amount: NaN
is encoded by: hsa:2720
has only substance units: false
is: SBO:0000252

metaR DM fol
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR ADPACTD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2ca62458_11f3_4035_8013_be48597fd129
has only substance units: false
constant: false
is encoded by: hsa:80864
is: SBO:0000252
is: Q99944
initial concentration: NaN
type: Species
initial amount: NaN
name: EGFL8
boundary condition: true

metaR C3DCe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2827715f_5860_44d1_b26c_90eb2a53b981
has only substance units: false
name: GALNT7
constant: false
is: SBO:0000252
is encoded by: hsa:51809
type: Species
initial concentration: NaN
initial amount: NaN
is: Q86SF2
boundary condition: true

metaR ALOX52
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: Arachidonate 5-lipoxygenase
is version of: http://identifiers.org/ec-code/1.13.11.34
modifier: MODEL1310110043#
reversible: false
product: MODEL1310110043#
fast: false

metaR HS1ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false
reversible: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110043#
name: heparan-N-sulfatase, lysosomal
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_2a0cf6ed_a8ee_41e1_b727_432d16756b07
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:93034
boundary condition: true
has only substance units: false
is: SBO:0000252
name: NT5C1B
is: Q96P26

metaR C141OHe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaM fmn e
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB01520
is: C00061
is: SBO:0000247
name: FMN
is: CHEBI:58210
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2
has only substance units: false

metaR B MANNASEly
product: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.25
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
name: beta-mannosidase, lysosomal
reversible: false

metaR FAOXC16OHC16r
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM f1a l
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: SBO:0000247
is: CHEBI:15936
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
name: F1alpha
initial concentration: 1.0

metaR ADRNt
reactant: MODEL1310110043#
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b4c8605c_2870_4160_bd9f_29f09b28f172
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: O00400
is encoded by: hsa:9197
is: SBO:0000252
name: SLC33A1

metaR CLPNDt
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_e51a2108_0106_4ce0_bb66_cefc43ecaba7
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3028
has only substance units: false
name: HSD17B10
is: Q99714
boundary condition: true
is: SBO:0000252
type: Species

metaR DGNSKm
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
name: deoxyguanosine kinase
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110043#
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_850e68e2_6ae6_4997_b87f_0dc5e9648061
is encoded by: hsa:AI090874
constant: false
name: _AI090874_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM 11 cis retfa e
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB00972
boundary condition: false
name: fatty acid 11-cis-retinol
is: CHEBI:57454
type: Species

metaM glysar c
is: http://identifiers.org/pubchem.compound/93131
name: Glycylsarcosine
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial amount: NaN

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_58065ce6_b3df_4405_a565_9511773aa523
boundary condition: true
is encoded by: hsa:AD000092
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: _AD000092_1_c
type: Species
is: SBO:0000252

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM stcoa c
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: C00412
is: HMDB01114
is: CHEBI:57394
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110043#_9d42c86f_a60c_4f64_8b13_28174a63c8cf
is encoded by: hsa:4694
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: NDUFA1
has only substance units: false
is: Q6IBB5
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_93ad4b00_8b5d_481b_92b7_29f43d308fd7
constant: false
type: Species
has only substance units: false
is encoded by: hsa:8140
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q8IV97
name: SLC7A5
initial amount: NaN

metaM succoa m
has only substance units: false
type: Species
is: CHEBI:57292
boundary condition: false
initial concentration: 1.0
is: HMDB01022
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
name: Succinyl-CoA

metaM gthrd m
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00125
initial concentration: 1.0
constant: false
is: CHEBI:57925

metaR r0434
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_23f3c96e_4f3a_4d30_b0ea_fe2dc2483963
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: MCCC1
is encoded by: hsa:56922
is: SBO:0000252
is: Q96RQ3

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaM C02528 r
name: chenodeoxycholate
is: SBO:0000247
is: HMDB00518
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:36234
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

metaR 13DAMPPOX
modifier: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000212
type: Reaction
fast: false
product: MODEL1310110043#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

metaR 34DHOXPEGOX
is: SBO:0000176
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110043#
type: Reaction
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: true
modifier: MODEL1310110043#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110043#_44bc3b42_bdbf_4977_ad9f_ada422fafd45
is: Q59E93
has only substance units: false
boundary condition: true
name: ANPEP
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:290
is: SBO:0000252
type: Species

metaR PPItm
is: SBO:0000185
name: diphopshate transporter, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000134

metaM leu L m
initial concentration: 1.0
is: CHEBI:15603
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00687
is: SBO:0000247
name: L-leucine
type: Species
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

http://identifiers.org/biomodels.db/MODEL1310110043#_8144f81d_3e0e_477d_961b_e0667ecb9997
initial concentration: NaN
is encoded by: hsa:6487
type: Species
has only substance units: false
initial amount: NaN
name: ST3GAL3
constant: false
boundary condition: true
is: SBO:0000252

metaM pmtcoa r
constant: false
type: Species
is: HMDB01338
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
initial concentration: 1.0
boundary condition: false
is: CHEBI:3454
has only substance units: false
is: SBO:0000247

metaR ADK3
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false
is described by: ECO:0000269
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
name: adentylate kinase (GTP)
modifier: MODEL1310110043#
reactant: MODEL1310110043#

metaM ksi deg21 l
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 21
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: CHEBI:12936
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_14275dc9_c066_411a_8a90_e2b58c4bf4d1
boundary condition: true
initial amount: NaN
name: GMPPB
type: Species
is: Q9Y5P6
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:29925

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: HMDB00257
is: CHEBI:16094
is: SBO:0000247

metaR r0732
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110043#

metaR r1617
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
fast: false
is: SBO:0000185
type: Reaction

metaR r0688
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110043#_28ee0cb4_2151_4d9c_8c2a_a5ef5e276dff
initial concentration: NaN
name: UPB1
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is: B3KNC1
is encoded by: hsa:51733
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_de9522b5_6557_4dc6_88d3_4cbf79b7a9c8
is encoded by: hsa:AI440329
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _AI440329_1_r
constant: false

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ee5c85cc_de72_4319_8c41_7b6dd35c46d3
is: P15104
constant: false
name: GLUL
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2752

metaM pheacgln c
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
initial amount: NaN
is: HMDB06344
type: Species
is: CHEBI:58310

http://identifiers.org/biomodels.db/MODEL1310110043#_b4a4f6cd_aa94_49bb_8d08_06a5c33bd1a5
name: _J03866_1_m
is encoded by: hsa:J03866
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR C101CRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR NADtpu
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
reversible: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
name: NAD transporter, peroxisome
type: Reaction
fast: false
is: SBO:0000185

metaM 3bcrn e
has only substance units: false
constant: false
is: C14143
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: HMDB04047
initial concentration: 1.0
name: 3-hydroxy butyryl carnitine
notes: FORMULA: C11H21NO5 CHARGE: 0

metaR SERt4
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
name: L-serine via sodium symport
fast: false
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110043#

metaM 3hexdcoa c
is: SBO:0000247
type: Species
name: 3-hydroxyhexadecanoylcoa
has only substance units: false
boundary condition: false
is: C05258
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: HMDB03932

metaM udpg r
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
constant: false
is: CHEBI:58367
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00286
has only substance units: false

metaR r0733
kinetic law: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_cd740990_7390_4182_ba84_b8b6b73f07c4
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q9P2X0
constant: false
name: DPM3
is encoded by: hsa:54344
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_541a8229_c287_444e_af88_210f2a0e19dc
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA977580
boundary condition: true
name: _AA977580_1_c
is: SBO:0000252
has only substance units: false

metaR FAOXOHMC10DC10c
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHMC10-->DC10)c
type: Reaction

metaR r1618
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_9c75d8ce_3770_48d9_b93f_7e5680e074f3
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2108
is: P13804
initial concentration: NaN
name: ETFA
is: SBO:0000252

metaR r2537
name: Utilized transport
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reactant: MODEL1310110043#
fast: false
reversible: true

metaM 2amac c
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
is: HMDB03609
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 2-aminoacrylic acid
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17123
initial amount: NaN

metaM hs deg3 l
constant: false
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate, degradation product 3
is: SBO:0000247
boundary condition: false
is: CHEBI:16126
type: Species
has only substance units: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12

metaM xol7ah2al c
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
initial concentration: 1.0
is: CHEBI:27428
constant: false
is: HMDB06894
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_7db77412_d3b9_41b1_8fdd_9d18fbb2eabc
boundary condition: true
is encoded by: hsa:9551
is: P56134
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ATP5J2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_7a7ae05f_6a4f_49e1_9004_3df9f069074c
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q96CD2
is: SBO:0000252
name: PPCDC
is encoded by: hsa:60490
initial concentration: NaN

metaR r1615
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true

metaR r0464
is described by: ECO:0000000
is: SBO:0000176
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
type: Reaction
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true

metaR r0734
is described by: ECO:0000000
reversible: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#

metaM coa x
type: Species
boundary condition: false
constant: false
is: C00010
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: HMDB01423
name: Coenzyme A
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57287

metaM adn e
initial concentration: 1.0
is: CHEBI:16335
type: Species
is: C00212
is: HMDB00050
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

http://identifiers.org/biomodels.db/MODEL1310110043#_0855f694_ce2c_49da_b2e0_fb2f7cfd4b04
is: SBO:0000252
is: O43916
boundary condition: true
name: CHST1
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:8534
type: Species

metaR r2534
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110043#

metaM pser L c
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: O-Phospho-L-serine
constant: false
initial concentration: 1.0
is: HMDB01721
is: CHEBI:15811
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_eb916c45_51dc_45ae_b74d_edf0e32bdfcd
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q8N4A0
is encoded by: hsa:8693
constant: false
name: GALNT4

metaR r0463
is: SBO:0000176
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is described by: ECO:0000000

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_5c56b542_4f46_4d05_b3a1_a50c5181c64f
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:AI620219
initial amount: NaN
constant: false
name: _AI620219_1_c
is: SBO:0000252
initial concentration: NaN

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
is: HMDB00126
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57597
name: Glycerol 3-phosphate
has only substance units: false
initial concentration: 1.0
is: C00093
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_7e08c3e8_4e60_42c1_a67b_3bcce318d9d7
initial concentration: NaN
constant: false
is: P24310
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: COX7A1
is encoded by: hsa:1346
type: Species
boundary condition: true

metaR ACGAM6PSi
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.4
name: N-acetylglucosamine-6-phosphate synthase
type: Reaction
kinetic law: MODEL1310110043#
reversible: false

metaM pheacgln e
initial concentration: 1.0
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: HMDB06344
type: Species
has only substance units: false
constant: false
is: CHEBI:58310

metaM Nacasp c
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16953
boundary condition: false
name: N-acetyl-L-aspartate(2-)
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: HMDB00812
initial amount: NaN
constant: false

metaM cspg a l
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false
is: HMDB02183
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110043#_f9620b51_3498_4d6f_bb70_cdcc3358a827
is: SBO:0000252
is: P07954
type: Species
initial concentration: NaN
name: FH
initial amount: NaN
has only substance units: false
is encoded by: hsa:2271
boundary condition: true
constant: false

metaR r1616
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0735
reactant: MODEL1310110043#
reversible: true
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110043#
is described by: ECO:0000000

metaM m4mpdol U c
constant: false
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1

metaR r0840
is: SBO:0000185
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
name: Free diffusion
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.70

metaR r2535
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#

metaM anth e
type: Species
name: anthranilate
initial amount: NaN
is: CHEBI:16567
initial concentration: 1.0
has only substance units: false
is: HMDB01123
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_c3738516_ac57_4a98_8a1e_c5ae5d553ac2
initial amount: NaN
name: _AI348006_1_c
constant: false
has only substance units: false
is encoded by: hsa:AI348006
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR CYTK9
reactant: MODEL1310110043#
name: cytidylate kinase (CMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110043#
type: Reaction
fast: false
product: MODEL1310110043#
reversible: true
is: SBO:0000176
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f79c30ad_7648_4845_865c_d44e45be0617
initial concentration: NaN
type: Species
is: Q9UBX3
is encoded by: hsa:1468
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: SLC25A10
is: SBO:0000252

metaR ASPNATm
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
name: aspartate N-acetyltransferase, mitochondrial
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_a3e3f1b8_64b7_463a_ad44_a55b36716343
name: B3GALT5
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10317
is: Q9Y2C3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b8e70d6c_f841_4c50_ae75_c98f6eb9a7cc
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79695
type: Species
boundary condition: true
initial amount: NaN
name: GALNT12
is: Q8IXK2

metaR NACHEX26ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaM eitetcoa x
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaR r2532
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
fast: false
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM odecoa m
is: SBO:0000247
is: HMDB01322
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
type: Species
is: CHEBI:57387

metaM oxa c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:30623
constant: false
type: Species
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
name: oxalate(2-)
initial amount: NaN

metaM atp e
name: ATP(4-)
type: Species
is: HMDB00538
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
is: C00002
has only substance units: false
is: SBO:0000247

metaR DM 5hpet LPAREN r RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r0539
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
reversible: true
fast: false
type: Reaction

metaR ARACHCPT2
fast: false
name: carnitine transferase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR GLCNACASE5ly
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110043#
product: MODEL1310110043#

metaM b2coa m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57332
is: HMDB02009
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial amount: NaN
type: Species
name: crotonoyl-CoA(4-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_f1ecac2a_34f4_409c_8b61_3835237bcaef
name: CMAS
initial concentration: NaN
is: Q8NFW8
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:55907
type: Species

metaR FACOAL245 1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110043#
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#

metaR OCTDECE1CRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_92323042_8832_439c_bad1_117b85d7a105
is encoded by: hsa:22978
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P49902
name: NT5C2
boundary condition: true
initial amount: NaN

metaM pmtcoa m
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01338
is: CHEBI:57379
is: C00154
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

http://identifiers.org/biomodels.db/MODEL1310110043#_81f34cfc_d24a_419d_8539_98f045d5c801
constant: false
name: PNMT
is: P11086
is encoded by: hsa:5409
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM 5tedtricoa m
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02288
boundary condition: false
initial concentration: 1.0
name: 5,8,11-tetradecatrienoylcoa
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247

metaR ASNTHRNaEx
reversible: false
is: SBO:0000185
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
modifier: MODEL1310110043#
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
is described by: ECO:0000269

metaR CYTK8
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110043#
name: cytidylate kinase (CMP,dATP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_ffe99476_a328_444d_9dfc_7b90c87b756d
is: P30838
initial amount: NaN
type: Species
name: ALDH3A1
is encoded by: hsa:218
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR SUCCCROT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_85e5f6ef_2007_4e83_8314_d4d945899268
name: PIK3CD:PIK3R1
has only substance units: false
has part: E7EX19
is: SBO:0000297
type: Species
constant: false
is encoded by: hsa:5295
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_f809352b_af19_40ac_b7f9_139e22410bff
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ADSSL1
initial amount: NaN
is: B3KTV4
type: Species
constant: false
is encoded by: hsa:122622
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_11a07d1a_2ec6_4da9_831a_e7d3a8d5a482
type: Species
constant: false
boundary condition: true
name: SLC26A6
is: SBO:0000252
is encoded by: hsa:65010
is: Q9Y3Y1
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR CITt4 4
is described by: ECO:0000006
fast: false
type: Reaction
kinetic law: MODEL1310110043#
name: citrate transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true

metaR C14STRr
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reversible: false
name: C-14 sterol reductase

metaM dopa e
is: HMDB00073
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: dopaminium(1+)
is: CHEBI:59905
boundary condition: false
type: Species
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN

metaR RE1796R
type: Reaction
reactant: MODEL1310110043#
name: RE1796
modifier: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false

metaR DOLDPP Uer
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.6.1.43
product: MODEL1310110043#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
fast: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is: SBO:0000176

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM ksii core2 pre5 g
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00175
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
constant: false
is: SBO:0000247
is: C00130

metaR r1619
modifier: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110043#
fast: false
reversible: true
product: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3f72112d_0091_49d9_a463_1368f7659d5e
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4842
is: SBO:0000252
type: Species
initial amount: NaN
is: B4DG68
name: NOS1

metaM atp c
is: SBO:0000247
type: Species
is: CHEBI:30616
boundary condition: false
is: HMDB00538
initial concentration: 1.0
constant: false
has only substance units: false
is: C00002
initial amount: NaN
name: ATP(4-)

metaR 41R1H2MAE12BOOX
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.4
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_7330f7fe_de14_4cdc_afff_c5059c16484c
is encoded by: hsa:51166
constant: false
name: AADAT
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q8N5Z0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_0efdf388_2372_4fa2_9757_52e485537af8
type: Species
name: PYCR2
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q96C36
is encoded by: hsa:29920
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_8463313a_afd7_4be8_8347_d9b09244355e
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC25A12
is encoded by: hsa:8604
boundary condition: true
initial concentration: NaN
is: O75746
constant: false

metaR FACOAL245 2
reactant: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110043#
name: fatty-acid--CoA ligase
fast: false
kinetic law: MODEL1310110043#
type: Reaction

metaM bilirub r
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57977
is: SBO:0000247

metaR SBT Dtde
reactant: MODEL1310110043#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110043#
name: D-sorbitol transport, extracellular
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
type: Reaction
is described by: ECO:0000134

metaM c10dc x
is: HMDB00651
constant: false
initial amount: NaN
name: sebacoyl carnitine
type: Species
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_b110278e_a0d2_4cb2_a04e_290b3ca51eef
type: Species
constant: false
has only substance units: false
is: P23634
is encoded by: hsa:493
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ATP2B4

http://identifiers.org/biomodels.db/MODEL1310110043#_83b7fb9a_ca96_47ec_9e67_a6205146f1ba
initial concentration: NaN
is encoded by: hsa:7371
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9BZX2
name: UCK2
constant: false

metaR CYTK8n
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
reversible: true
name: cytidylate kinase (CMP,dATP),nuclear

metaR DNDPt15m
type: Reaction
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
is described by: ECO:0000269
name: dUDP transport via dGDP antiport
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR CLOXAtex2
is described by: ECO:0000304
name: chloride transport via oxalate countertransport (2:1)
type: Reaction
fast: false
kinetic law: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
product: MODEL1310110043#
modifier: MODEL1310110043#

metaR FAOXC183806m
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110043#
reversible: false
product: MODEL1310110043#
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaM dopa c
is: HMDB00073
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:59905
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
is: SBO:0000247

metaR PHACCOAGLNAC
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
kinetic law: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110043#

metaM 3bcrn c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB04047
boundary condition: false
initial concentration: 1.0
name: 3-hydroxy butyryl carnitine
is: SBO:0000247
notes: FORMULA: C11H21NO5 CHARGE: 0
is: C14143
constant: false

metaR r0739
fast: false
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:

metaR ASPte
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
product: MODEL1310110043#
name: diffusion of aspartate into blood
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_6cea8606_84cf_4638_bfe2_a36710ec2315
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is: O95167
initial amount: NaN
is encoded by: hsa:4696
initial concentration: NaN
name: NDUFA3

http://identifiers.org/biomodels.db/MODEL1310110043#_67987199_33a2_486d_9d78_f95da1a7b6d2
initial concentration: NaN
is: SBO:0000252
constant: false
name: GGH
initial amount: NaN
boundary condition: true
is encoded by: hsa:8836
type: Species
has only substance units: false
is: Q92820

metaR CYTK5
reactant: MODEL1310110043#
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110043#

metaM coa m
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: Coenzyme A
type: Species
is: C00010
has only substance units: false
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110043#_a3e63597_a8bd_4562_bc45_0072fc54529c
type: Species
name: PRPS1
is encoded by: hsa:5631
initial amount: NaN
boundary condition: true
is: P60891
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM cs e deg7 l
has only substance units: false
initial concentration: 1.0
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_725b5994_f407_4068_b240_76f16766d714
is encoded by: hsa:4669
initial concentration: NaN
is: P54802
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: NAGLU
boundary condition: true

metaR r1610
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR DURIK1
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000254
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
reversible: false
name: deoxyuridine kinase (ATP:Deoxyuridine)
is version of: http://identifiers.org/ec-code/2.7.1.21
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR TREHe
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.28
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
is: SBO:0000176
name: alpha,alpha-trehalase
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_e0e3e426_ba0d_4ecc_90bf_b230937d70d5
is: Q59E93
has only substance units: false
is: SBO:0000252
constant: false
name: ANPEP
is encoded by: hsa:290
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR CSAPASEly
reversible: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110043#

metaR CITtbm
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
name: citrate transport, mitochondrial
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
kinetic law: MODEL1310110043#
fast: false

metaR CYTK4
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
name: cytidylate kinase (dCMP)(GTP)
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:

metaM inost e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00211
has only substance units: false
constant: false
name: myo-inositol
initial amount: NaN
is: CHEBI:17268

http://identifiers.org/biomodels.db/MODEL1310110043#_0284db5e_98f1_48b5_a37d_d37e3981c363
is encoded by: hsa:AI539321
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AI539321_1_c

metaM coa n
constant: false
is: CHEBI:57287
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
name: coenzyme A(4-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_c0783c98_8ba8_4375_b9c9_05584cad9f54
is encoded by: hsa:217
type: Species
name: ALDH2
is: P05091
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_95c5fc58_2cdc_4d87_9600_24cf1c9cd4f1
is encoded by: hsa:518
boundary condition: true
initial concentration: NaN
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM cs a deg5 l
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C23H36O24S CHARGE: -2
boundary condition: false
is: CHEBI:15936
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_22b097c4_1d9c_428a_8858_b57cc2f0ec6b
is: SBO:0000252
is: O43674
is encoded by: hsa:4711
name: NDUFB5
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR r0311
type: Reaction
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM dlnlcgcrn m
name: dihomo-gamma-linolenyl carnitine
is: CHEBI:16004
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: HMDB01311
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species

metaM cspg a e
has only substance units: false
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial concentration: 1.0
is: CHEBI:16040
boundary condition: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
is: HMDB00630
is: SBO:0000247
type: Species

metaM sgalside hs g
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: sulfatide galactocerebroside
is: HMDB00061
is: CHEBI:58343
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaR CYTK7
fast: false
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,UTP)
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#

metaR ATPH1e
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is version of: http://identifiers.org/ec-code/3.6.1.6
name: ATP diphosphohydrolase
is: SBO:0000176
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110043#

metaR r2120
modifier: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185

metaM pmtcoa x
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
boundary condition: false
is: C00154
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_849a5964_b4e4_4d4c_98d5_a0f693f6b714
name: BCAT2
has only substance units: false
is: O15382
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:587
initial amount: NaN
constant: false
initial concentration: NaN

metaR RE2799C
is described by: ECO:0000000
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
name: RE2799
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110043#

metaM ak2lgchol hs c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6975
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial amount: NaN
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: C04317
boundary condition: false
has only substance units: false

metaR ARACHCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
product: MODEL1310110043#
is described by: ECO:0000000
name: carnitine transferase
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM 3hexdcoa m
is: SBO:0000247
has only substance units: false
name: 3-hydroxyhexadecanoylcoa
is: C05258
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03932
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
boundary condition: false

metaM odecoa r
is: CHEBI:57387
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01322
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
constant: false
name: oleoyl-CoA(4-)

metaM arachdcrn c
is: CHEBI:57387
initial amount: NaN
name: C20:4 carnitine
type: Species
has only substance units: false
is: HMDB01322
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR CYTK6
product: MODEL1310110043#
reactant: MODEL1310110043#
name: cytidylate kinase (CMP,CTP)
modifier: MODEL1310110043#
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR RE2660C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110043#
name: RE2660
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d6499248_0a20_4f85_ae8c_b8515e46b34e
boundary condition: true
is: SBO:0000252
name: ACOT8
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: O14734
is encoded by: hsa:10005
has only substance units: false

metaM inost c
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: HMDB00211
name: myo-inositol
type: Species
is: CHEBI:17268

metaR r2121
reactant: MODEL1310110043#
modifier: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110043#

metaR r0841
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
kinetic law: MODEL1310110043#
type: Reaction
name: Free diffusion
is: SBO:0000185
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.271

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR r0531
fast: false
modifier: MODEL1310110043#
type: Reaction
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
kinetic law: MODEL1310110043#

metaM cs e l
constant: false
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
is: HMDB02183
type: Species
is: CHEBI:36005
initial amount: NaN
has only substance units: false
boundary condition: false

metaM dctp c
is: HMDB00998
boundary condition: false
has only substance units: false
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16311
type: Species
constant: false
initial amount: NaN
is: C00458

metaR r1613
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_267108a6_66a7_4cad_bd6c_79795739e859
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:3158
boundary condition: true
is: P54868
initial concentration: NaN
initial amount: NaN
name: HMGCS2
type: Species

metaM ddsmsterol r
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB03896
boundary condition: false
has only substance units: false
type: Species
name: 7-dehydrodesmosterol
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: CHEBI:27910

metaR r0236
kinetic law: MODEL1310110043#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
type: Reaction

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_4f471806_e2e0_4450_af0e_4ef22df75094
boundary condition: true
is encoded by: hsa:490
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: ATP2B1
is: P20020

metaR CYTK1
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reversible: true
name: cytidylate kinase (CMP)
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b49a10e3_a99c_4773_bc0c_feb55524577d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: _T83654_1_c
is encoded by: hsa:T83654
type: Species

metaM ipdp x
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:128769
is: HMDB01347
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: isopentenyl diphosphate(3-)
boundary condition: false
is: SBO:0000247

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:58190
has only substance units: false
name: ethamp[c]
is: HMDB00224
initial amount: NaN
initial concentration: 1.0

metaR GLCt1r
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
name: glucose transport (uniport)
fast: false
type: Reaction

metaM gly c
is: HMDB00123
constant: false
type: Species
is: C00037
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0
is: CHEBI:3339
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Glycine
is: SBO:0000247

metaM atp n
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
constant: false
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
is: HMDB00538
is: SBO:0000247
name: ATP(3-)
boundary condition: false
has only substance units: false

metaM anth c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
constant: false
is: CHEBI:16567
name: anthranilate
initial amount: NaN
type: Species

metaR r0842
kinetic law: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000185
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
reversible: true
name: Postulated transport reaction
modifier: MODEL1310110043#
is described by: ECO:0000000

metaM nmn c
is: HMDB00229
type: Species
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: C00455
is: CHEBI:14649
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: NMN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_3304a11f_6a2a_444d_bfc8_dd0268a941e6
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9962
has only substance units: false
constant: false
is: SBO:0000252
name: SLC23A2

metaM CE5126 x
constant: false
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: (2R)-pristanoyl-CoA
initial concentration: 1.0
is: CHEBI:12947

metaR r1614
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM ak2lgchol hs e
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
is: C04317
is: http://identifiers.org/pubchem.compound/6975
type: Species
boundary condition: false

metaR CYOR u10m
reversible: false
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110043#
name: ubiquinol-6 cytochrome c reductase, Complex III
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000134
fast: false
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#

metaM retinol e
is: HMDB00305
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
boundary condition: false
type: Species
constant: false
name: retinol
is: SBO:0000247
initial amount: NaN
is: CHEBI:50211

metaR TSTSTERONESte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
type: Reaction
reversible: true
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
name: sulfonated testosterone transport
is described by: ECO:0000000
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_bb704adf_790f_4119_88fb_2c5ae4184a87
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2876
is: SBO:0000252
name: GPX1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_a3b26b34_70f9_484b_9daa_2a21bdddbc64
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: F6KD01
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5728
name: PTEN

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_872ce14e_9663_4bba_bcb2_414a119c69f3
is encoded by: hsa:1384
initial concentration: NaN
has only substance units: false
name: CRAT
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR PI345P5P
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
product: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000176
fast: false
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD

metaM coa r
name: Coenzyme A
constant: false
is: SBO:0000247
is: CHEBI:57287
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: HMDB01423

metaM atp m
type: Species
boundary condition: false
is: C00002
constant: false
initial amount: NaN
is: HMDB00538
is: SBO:0000247
name: ATP(4-)
initial concentration: 1.0
is: CHEBI:57299
has only substance units: false

metaM sgalside hs c
name: sulfatide galactocerebroside
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16523
initial concentration: 1.0
is: HMDB03406

http://identifiers.org/biomodels.db/MODEL1310110043#_b4f4a0c3_6c0b_4656_9603_d9f08d052c5f
initial concentration: NaN
is: SBO:0000252
is: Q9P0Z9
has only substance units: false
boundary condition: true
type: Species
constant: false
name: PIPOX
is encoded by: hsa:51268
initial amount: NaN

metaR r0730
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110043#
product: MODEL1310110043#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110043#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM gly e
initial concentration: 1.0
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00037
is: CHEBI:3339
initial amount: NaN
name: Glycine
type: Species
is: HMDB00123

metaR r1611
type: Reaction
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110043#

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
is: CHEBI:50211
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: retinol
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_2fa6cd30_4f0e_4f84_aea7_2ac088641218
is: Q96CA6
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: ACAA1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:30

metaM ei11ecoa x
constant: false
type: Species
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 11-eicosenoylcoa

metaR PYAM5POr
reactant: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
reversible: true
name: pyridoxamine 5'-phosphate oxidase

metaR CYTK3
is described by: ECO:0000269
product: MODEL1310110043#
name: cytidylate kinase (CMP)(GTP)
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110043#

metaR AMETr
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
name: S-Adenosyl-L-methionine intracellular diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ

metaM s2l2n2m2masn e
has only substance units: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: C00255
initial concentration: 1.0
is: HMDB00244
is: SBO:0000247
name: de-Fuc form of PA6
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:3554

metaR r0731
fast: false
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000000

metaM peamn c
is: SBO:0000247
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: 2-phenylethanaminium
initial amount: NaN
constant: false
is: CHEBI:225237

metaR GLUt2m
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: true
fast: false
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000269
name: L-glutamate reversible transport via proton symport, mitochondrial
reactant: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_627e30ec_18c4_49e0_9cdc_2ac07ff5d908
name: ALG2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:85365
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR r1612
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a23940a3_4fa1_4b7e_af2b_7077cac96fa8
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q8IW54
initial concentration: NaN
boundary condition: true
constant: false
name: PDE2A
type: Species
is encoded by: hsa:5138

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR EX 5homeprazole LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5 hydroxy omeprazole exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_19f55bce_5a41_453e_a4b6_d0b8f94979ac
is: Q7Z4L0
is encoded by: hsa:341947
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: COX8C

http://identifiers.org/biomodels.db/MODEL1310110043#_a2a4622d_5673_45b2_8753_ea615730d66f
initial concentration: NaN
name: VNN2
is: O95498
has only substance units: false
boundary condition: true
is encoded by: hsa:8875
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM retinal cis 13 r
name: 13-cis-retinal
is: HMDB06220
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:45487

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR CYTK2
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: cytidylate kinase (dCMP)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_e6c05232_17cc_46c2_ad6a_2387d4372751
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA278423
name: _AA278423_1_c
has only substance units: false
type: Species
is: SBO:0000252

metaM hs deg2 l
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
is: CHEBI:17180
has only substance units: false
is: SBO:0000247
name: heparan sulfate, degradation product 2
boundary condition: false
is: HMDB01352
initial amount: NaN

metaR S23T2g
product: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
reactant: MODEL1310110043#
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
kinetic law: MODEL1310110043#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_fc82e308_d30d_457e_a32a_5aad47f74b13
type: Species
boundary condition: true
is encoded by: hsa:8883
constant: false
has only substance units: false
is: SBO:0000252
name: NAE1
initial amount: NaN
is: A8MU28
initial concentration: NaN

metaR r1292
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110043#
name: Postulated transport reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_1ea1d802_9c6b_44c5_809d_00aeb2793fe1
boundary condition: true
name: PCBD1
is: P61457
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5092

metaR r2115
modifier: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_609de532_1012_4788_b80f_d2baa9babdbc
initial concentration: NaN
type: Species
is encoded by: hsa:6817
name: SULT1A1
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR G14T3g
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reversible: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR r0013
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
kinetic law: MODEL1310110043#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
reactant: MODEL1310110043#

metaR r1291
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
name: Postulated transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM c16dc c
initial amount: NaN
initial concentration: 1.0
is: HMDB00712
notes: FORMULA: C23H42NO6 CHARGE: -1
name: Hexadecanedioic acid mono-L-carnitine ester
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_c97afe38_505a_4326_a16d_6d50cb483994
type: Species
name: _AA614647_1_c
has only substance units: false
is encoded by: hsa:AA614647
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR LCADi
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
name: lactaldehyde dehydrogenase
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM bilirub c
has only substance units: false
boundary condition: false
is: CHEBI:57977
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
name: bilirubin(2-)
initial amount: NaN
is: HMDB00054

http://identifiers.org/biomodels.db/MODEL1310110043#_5bc3b926_098b_4e50_8631_c847a7699eae
is encoded by: hsa:2592
initial concentration: NaN
is: B4E097
is: SBO:0000252
name: GALT
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaM h e
type: Species
boundary condition: false
is: C00080
is: CHEBI:24636
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
constant: false
name: proton

metaR C160CPT2
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
name: C160 transport into the mitochondria
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: false
is described by: ECO:0000269

metaR ALAt2r
product: MODEL1310110043#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110043#
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110043#
name: L-alanine reversible transport via proton symport
fast: false
reactant: MODEL1310110043#

metaR A4GNT2g
product: MODEL1310110043#
type: Reaction
reversible: false
modifier: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000176
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110043#
fast: false

metaM coa e
is: SBO:0000247
has only substance units: false
is: HMDB01423
name: Coenzyme A
is: CHEBI:57287
initial amount: NaN
is: C00010
constant: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
type: Species

metaR GLYOX
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#
name: hydroxyacylglutathione hydrolase
is described by: ECO:0000269
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.6

metaR r2114
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110043#

metaR r0317
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110043#
type: Reaction
fast: false
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a9bc804c_8f41_48e7_9c42_2c339478ccf6
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: P48067
constant: false
name: SLC6A9
is encoded by: hsa:6536
boundary condition: true
has only substance units: false

metaM gdp m
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00035
initial amount: NaN
constant: false
name: GDP
is: CHEBI:58189
has only substance units: false
is: HMDB01201
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

http://identifiers.org/biomodels.db/MODEL1310110043#_a41020f7_8b5c_4a80_8390_cfd50bb9540b
is: E5KS60
is encoded by: hsa:8803
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: SUCLA2
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_8238d0db_e80f_43ce_bcd7_bde9f069be23
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3945
type: Species
is: P07195
constant: false
name: LDHB
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM udpg c
is: C00029
type: Species
name: UDPglucose
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00286
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_be7d9a6b_87a9_4cee_b33f_a45ae0e36896
boundary condition: true
name: NDUFA5
initial amount: NaN
is encoded by: hsa:4698
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: Q16718
is: SBO:0000252

metaM xoldiolone r
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
constant: false
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: CHEBI:28477
has only substance units: false

metaR C160CPT1
name: production of Palmitoylcarnitine
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false

metaM 5tedtricoa x
initial concentration: 1.0
type: Species
has only substance units: false
name: 5,8,11-tetradecatrienoylcoa
initial amount: NaN
is: HMDB02288
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
constant: false

metaR THMP
name: thiamin phosphatase
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
is described by: ECO:0000000
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_e8d3e3cc_8dde_409c_9f9c_a19b251b3a12
has only substance units: false
is: Q9BVK2
name: ALG8
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:79053
type: Species
initial amount: NaN
initial concentration: NaN

metaR GLYAMDTRc
name: glycine amidinotransferase (c)
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.4.1
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c
reversible: true
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR MELATNOX
is version of: http://identifiers.org/ec-code/1.14.13.48
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
reactant: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
name: Melatonin:NADP oxidoreductase
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.14.1
kinetic law: MODEL1310110043#

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a0741fca_af54_4adc_be9e_4da9a9c17356
is encoded by: hsa:5150
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: PDE7A
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2117
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185

metaR MMSAD3m
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#

metaM succ e
initial concentration: 1.0
has only substance units: false
is: HMDB00254
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: succinate(2-)
initial amount: NaN
is: CHEBI:30031

metaM subeac c
has only substance units: false
constant: false
initial amount: NaN
name: suberic acid
notes: FORMULA: C8H12O4 CHARGE: -2
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00893
is: SBO:0000247

metaR ALR3
reversible: false
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110043#
product: MODEL1310110043#
name: aldose reductase (acetol)
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false

metaR RE3568C
type: Reaction
fast: false
is described by: ECO:0000000
name: RE3568
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#

metaR PPDOy
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
product: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110043#

metaM c16dc e
boundary condition: false
initial amount: NaN
is: HMDB00712
name: Hexadecanedioic acid mono-L-carnitine ester
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C23H42NO6 CHARGE: -1

metaM gdp n
type: Species
initial amount: NaN
is: HMDB01201
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
is: CHEBI:58189
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_d15d3688_199f_4c2b_bb2f_a1f082ac5a8d
name: PDE4A
type: Species
is encoded by: hsa:5141
constant: false
is: P27815
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM coa g
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
name: coenzyme A(4-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57287
constant: false
has only substance units: false
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110043#_9a8e017a_9151_4a54_89f1_cd672e073de0
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _HG2846_HT2983_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_3801fe9d_b826_470b_a1c4_efb3ea1a82f0
initial amount: NaN
type: Species
is: P16118
name: PFKFB1
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5207
initial concentration: NaN

metaM bilirub e
is: HMDB00054
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
name: bilirubin(2-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57977
constant: false
boundary condition: false
type: Species

metaR HAS2
reactant: MODEL1310110043#
name: hyaluronan synthase
kinetic law: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
type: Reaction
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000185

metaM h g
has only substance units: false
boundary condition: false
is: CHEBI:24636
name: proton
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
constant: false
type: Species

metaR r2116
kinetic law: MODEL1310110043#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR PYRt2r
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000269
name: pyruvate reversible transport via proton symport
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
modifier: MODEL1310110043#
product: MODEL1310110043#

metaR FUCtly
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
name: L-fucose efflux from lysosome
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_cfba2e2d_30ab_47a7_98ce_5e8fea5231e7
type: Species
initial amount: NaN
boundary condition: true
name: SLC26A7
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:115111
is: Q8TE54

metaR ALR2
name: aldose reductase (methylglyoxal)
kinetic law: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110043#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
product: MODEL1310110043#
reactant: MODEL1310110043#

metaR PFK26
name: 6-phosphofructo-2-kinase
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
reactant: MODEL1310110043#
reversible: false
is: SBO:0000176
modifier: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.105
fast: false

metaR HAS1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: hyaluronan synthase
product: MODEL1310110043#
reversible: false
fast: false

metaR DOLPH Uer
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110043#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
name: Dolichol-phosphate phosphohydrolase, human (uterus)

metaR ALAR
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000212
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: alanine racemase

metaM udpg e
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: HMDB00286
is: CHEBI:58367
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
has only substance units: false

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110043#
type: Reaction
fast: false
modifier: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM thf c
initial concentration: 1.0
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: C00101

metaR ALAGLYexR
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
name: L-alanine/glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110043#
reactant: MODEL1310110043#

metaR GTHPm
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
product: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
is: SBO:0000176
name: glutathione peroxidase, mitochondria
type: Reaction
kinetic law: MODEL1310110043#

metaR 34DHPHEt
fast: false
reactant: MODEL1310110043#
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine transport
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110043#

metaR SCP21cx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_46787db0_9407_4c77_a905_5735b4e5f21e
initial concentration: NaN
initial amount: NaN
name: SULT1A2
has only substance units: false
is encoded by: hsa:6799
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM succ c
is: HMDB00254
name: Succinate
is: CHEBI:30031
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: C00042
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR TAURtcx
modifier: MODEL1310110043#
is: SBO:0000185
name: taurine transport (sodium symport) (cytosol to peroxisome)
kinetic law: MODEL1310110043#
type: Reaction
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:8010975 NOTES:SAB
fast: false
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#

metaR CMPSAS
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
name: CMP sialic acid synthase
is version of: http://identifiers.org/ec-code/2.7.7.43
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000304

metaR r0838
product: MODEL1310110043#
reactant: MODEL1310110043#
name: Free diffusion
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_e8bfa55c_6a12_47a7_8eed_96ffe202fadb
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:50484
is: Q7LG56
name: RRM2B
initial concentration: NaN

metaM 5thf e
name: pentaglutamyl folate (THF)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
is: SBO:0000247
boundary condition: false
is: HMDB06487
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_f94fa9e1_7cda_41b6_877e_07882e5216aa
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5152
name: PDE9A
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR r2110
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR CYTDK1
reversible: false
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110043#
is described by: ECO:0000254
type: Reaction
name: ATPcytidine 5-phosphotransferase

http://identifiers.org/biomodels.db/MODEL1310110043#_d4e12730_2be1_42c2_8743_adfabcb31b28
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: Q9UHW9
initial concentration: NaN
has only substance units: false
name: SLC12A6
constant: false
is encoded by: hsa:9990

metaR DM gpi sig er
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaM val L e
is: CHEBI:16414
constant: false
boundary condition: false
name: L-valine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00883
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
initial amount: NaN

metaR PRFGS
is described by: ECO:0000269
modifier: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
type: Reaction
fast: false
name: phosphoribosylformylglycinamidine synthase
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/6.3.5.3

metaR PPDOx
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
is: SBO:0000176
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
reversible: false

metaM gacpail hs c
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
type: Species
is: HMDB00128
constant: false
is: CHEBI:16344
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
boundary condition: false

metaM dheas c
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247
is: HMDB01032
has only substance units: false
is: CHEBI:57905
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR UREAt5
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
reversible: true
name: urea, water cotransport
is: SBO:0000185
product: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD

metaR PYRt2p
reversible: true
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
fast: false
name: pyruvate peroxisomal transport via proton symport

metaR ACETONEt2
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185
name: acetone transport via proton symport
modifier: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
type: Reaction
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaM icit x
boundary condition: false
name: isocitrate(3-)
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
is: SBO:0000247
is: HMDB00193
initial amount: NaN

metaM thf e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57453
is: HMDB01846
type: Species
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR r2113
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#

metaM 6hoxmelatn c
is: http://identifiers.org/pubchem.compound/7954
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
constant: false
initial concentration: 1.0
is: HMDB04081
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: 6-Hydroxymelatonin
is: SBO:0000247
is: C05643

metaM HC02024 r
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C45H76O2 CHARGE: 0 INCHI: InChI=1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
initial amount: NaN
is: CHEBI:41509
name: Cholesterol-ester-lin
is: SBO:0000247
has only substance units: false

metaM ump r
is: HMDB00288
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
is: CHEBI:57865
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_8981d25e_b034_4974_8cfd_656ef7c07642
type: Species
is: SBO:0000297
is encoded by: hsa:5149
is encoded by: hsa:5145
boundary condition: true
initial concentration: NaN
has part: Q13956
has only substance units: false
has part: B7Z9T9
name: PDE6A:PDE6H:PDE6B
has part: P16499
initial amount: NaN
constant: false
is encoded by: hsa:5158

metaM gtp m
initial amount: NaN
name: GTP
is: SBO:0000247
is: C00044
has only substance units: false
is: CHEBI:37565
initial concentration: 1.0
type: Species
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
constant: false

metaM C05965 e
is: SBO:0000247
initial amount: NaN
is: HMDB04243
constant: false
initial concentration: 1.0
is: CHEBI:57444
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_2e206d65_a63f_473b_b9b1_c5a942a0f795
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q8N695
is encoded by: hsa:160728
has only substance units: false
initial concentration: NaN
name: SLC5A8

http://identifiers.org/biomodels.db/MODEL1310110043#_9bb34e3d_c30e_43a9_8705_f0c87954d96d
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P52824
name: DGKQ
is encoded by: hsa:1609

metaM coa l
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: coenzyme A(4-)
constant: false
boundary condition: false
is: HMDB01423
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110043#_cbfe4eae_52f0_42f7_9fc9_540963162a09
name: SLC2A4
is: P14672
is encoded by: hsa:6517
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaR S6T17g
reactant: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
fast: false
kinetic law: MODEL1310110043#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
is described by: ECO:0000000

metaM HC01397 m
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_865dc34c_2749_4bd7_a2c9_af6143e405af
name: GALNT6
is: SBO:0000252
boundary condition: true
is: Q8NCL4
constant: false
type: Species
is encoded by: hsa:11226
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR LNLCCPT2
reversible: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110043#
fast: false
name: carnitine transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR PYRt2m
kinetic law: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
product: MODEL1310110043#
name: pyruvate mitochondrial transport via proton symport

metaR CSNAT2x
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.137
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110043#
fast: false
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110043#_b41c016d_d2bd_4dcd_a2a9_c31e6d709d3f
has only substance units: false
initial amount: NaN
is encoded by: hsa:4952
is: SBO:0000252
name: OCRL
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_31affd1f_4664_44e0_b002_64c189ecf73e
type: Species
is: Q8IUC8
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:114805
name: GALNT13
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_a0eec683_9760_47fc_8254_f7705a481e12
has only substance units: false
is encoded by: hsa:3706
name: ITPKA
initial concentration: NaN
boundary condition: true
is: P23677
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

metaM leu L c
initial concentration: 1.0
boundary condition: false
is: CHEBI:15603
constant: false
initial amount: NaN
name: L-leucine
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
has only substance units: false
is: SBO:0000247

metaR r2112
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110043#
fast: false

metaM gtp n
has only substance units: false
boundary condition: false
type: Species
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
initial amount: NaN
is: CHEBI:37565
initial concentration: 1.0
name: GTP(4-)
is: SBO:0000247

metaM pd3 c
initial concentration: 1.0
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
name: Previtamin D3
is: SBO:0000247
type: Species
is: HMDB06500
boundary condition: false
has only substance units: false
initial amount: NaN

metaM dheas e
type: Species
is: HMDB01032
is: CHEBI:57905
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
constant: false
has only substance units: false
initial amount: NaN

metaR FAOXC17C15m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR ORPT
name: orotate phosphoribosyltransferase
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.10
reactant: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_861689a7_950e_4eb8_8ae2_d670fc7f538f
constant: false
is: SBO:0000252
is encoded by: hsa:80055
boundary condition: true
name: PGAP1
is: Q75T13
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_4a26ec36_9540_40fe_a730_e0a67f4e5950
is: SBO:0000252
is: B7Z3W8
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6536
initial amount: NaN
initial concentration: NaN
name: SLC6A9

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110043#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269

metaM gly m
constant: false
has only substance units: false
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
is: C00037
initial amount: NaN
type: Species
boundary condition: false
name: Glycine
is: HMDB00123
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_4ddbdaed_cc0e_42d8_a907_8fe29d28d790
name: _LOC728997_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:LOC728997

metaM ksi deg36 l
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I, degradation product 36
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB00143

metaR r0839
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_265e8ef5_93e7_41a5_bff1_2de136cc8ee0
is: P51160
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:5146
initial concentration: NaN
is: SBO:0000252
name: PDE6C

http://identifiers.org/biomodels.db/MODEL1310110043#_d2de1db4_add8_431e_bd08_3a9678a17c3d
name: GALNT10
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: Q86SR1
is encoded by: hsa:55568
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_72c0c838_e148_4f44_8fde_2ace32e567a2
type: Species
initial amount: NaN
has only substance units: false
is: B7Z428
boundary condition: true
constant: false
is encoded by: hsa:10020
initial concentration: NaN
name: GNE
is: SBO:0000252

metaR C60CPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaM xyl D l
is: CHEBI:15936
name: aldehydo-D-xylose
constant: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR PAIL45P HStn
type: Reaction
fast: false
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110043#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_8ac752cf_de72_4f7c_8bf8_78335365d093
is: P09960
boundary condition: true
type: Species
is encoded by: hsa:4048
initial amount: NaN
is: SBO:0000252
name: LTA4H
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9329014a_1578_44a7_94cf_0dd2a6190505
name: NDUFB2
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: H7C5B8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4708

metaM eitetcoa m
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaR RE1796M
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reactant: MODEL1310110043#
reversible: true
fast: false
name: RE1796
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
type: Reaction

metaR IDOURte
reversible: true
reactant: MODEL1310110043#
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110043#

metaM gdp g
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
name: GDP(3-)
is: CHEBI:58189
is: SBO:0000247

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_2cc62535_e7ae_4bd2_a99a_a30b8fad74a9
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6241
is: P31350
name: RRM2
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM gtp c
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
is: C00044
constant: false
has only substance units: false
is: HMDB01273
is: CHEBI:37565
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: GTP

metaR r0728
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
product: MODEL1310110043#
reactant: MODEL1310110043#

metaM imp e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
name: IMP(2-)
is: CHEBI:58053
has only substance units: false

metaM lac D c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01311
type: Species
boundary condition: false
initial concentration: 1.0
name: (R)-lactate
is: SBO:0000247
is: CHEBI:16004

metaM omhdecacid r
boundary condition: false
name: w-hydroxydecanoicacid
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H19O3 CHARGE: -1
constant: false
is: HMDB12969
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_269d41a2_611c_4288_9543_205a11478ee5
constant: false
name: PTDSS1
is: SBO:0000252
initial concentration: NaN
is: P48651
is encoded by: hsa:9791
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR r0680
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110043#
is: SBO:0000176
reversible: true
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#

metaM leu L e
is: HMDB00687
is: CHEBI:15603
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: L-leucine
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
boundary condition: false

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR CITt4 2
reactant: MODEL1310110043#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
modifier: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_5948658f_29b4_4069_ac9b_f00c7e3cda55
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:NM 013421
name: _NM_013421_1_m

http://identifiers.org/biomodels.db/MODEL1310110043#_a8de80e6_309a_459f_9a70_e3781fd30be0
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI818585
name: _AI818585_1_c
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_d97757eb_2469_4736_993e_9ded9f30038b
initial concentration: NaN
initial amount: NaN
name: NDUFS7
is encoded by: hsa:374291
constant: false
is: SBO:0000252
is: O75251
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_451d7686_fbe2_4386_98b3_e40766b09637
is: P40926
constant: false
name: MDH2
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4191
has only substance units: false

metaM succ m
type: Species
constant: false
is: CHEBI:30031
name: Succinate
boundary condition: false
is: SBO:0000247
is: HMDB00254
is: C00042
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0

metaR C12DCACT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7126b06d_4570_4b58_a614_a52149f4217e
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5289
is: Q8NEB9
name: PIK3C3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_bd3e061a_a07e_4d6d_90be_ba2ab1b4d1d0
constant: false
is: P08237
is: SBO:0000252
type: Species
is encoded by: hsa:5213
has only substance units: false
initial amount: NaN
boundary condition: true
name: PFKM
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_f40ec7c4_75fa_4ab1_aa96_990a078b1bf2
has only substance units: false
is encoded by: hsa:204
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: AK2
is: P54819

http://identifiers.org/biomodels.db/MODEL1310110043#_0f5e5093_ac02_4d28_9477_9120b7e49334
boundary condition: true
is: Q9Y619
constant: false
is encoded by: hsa:10166
is: SBO:0000252
has only substance units: false
name: SLC25A15
type: Species
initial concentration: NaN
initial amount: NaN

metaM gdp e
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
is: HMDB01201
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: GDP(3-)
initial amount: NaN
is: CHEBI:58189
has only substance units: false

metaM imp c
is: HMDB00175
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00130
name: IMP
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

metaM odecoa c
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:3793
is: HMDB01322
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR AACOAT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110043#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110043#
name: Acetoacetyl-CoA:acetate CoA-transferase
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
reversible: true
type: Reaction
kinetic law: MODEL1310110043#

metaR GLYCLTtp
name: glycolate transport into peroxisome
reversible: false
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110043#

metaM val L c
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
boundary condition: false
is: CHEBI:16414
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: L-valine

metaR FMNAT
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.2
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
name: FMN adenylyltransferase
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110043#

metaM lac D e
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01311
constant: false
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR B3GNT34g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110043#
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_3cebb0c9_4d9c_47fd_bb8b_b07d6c0a062c
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: SUCLG1
is: P53597
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8802

metaR THMPPtm
kinetic law: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
type: Reaction
is described by: ECO:0000000
name: Thiamine diphosphate transport in via anion antiport, mitochondria
is: SBO:0000185

metaR DCYTDn
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
name: deoxycytidine deaminase, nuclear
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110043#
reversible: false
product: MODEL1310110043#

metaR DGCHOLte
product: MODEL1310110043#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110043#_4ea3fcd5_7e57_4ced_a092_70c15d92ddec
initial amount: NaN
is: P00491
initial concentration: NaN
boundary condition: true
name: PNP
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4860

http://identifiers.org/biomodels.db/MODEL1310110043#_ec517d1e_15dc_4b1d_9c8a_c4a8392f66a4
constant: false
name: CYP2C19
is encoded by: hsa:1557
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P33261

metaR r1088
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110043#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110043#
fast: false
name: Active transport

metaR NDPK9n
reversible: true
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM tchola x
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
is: HMDB00036
is: CHEBI:36257
name: taurocholate
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaR STS2
name: Steryl-sulfatase
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.2
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ

metaR PI34P5K
is version of: http://identifiers.org/ec-code/2.7.1.68
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
is: CHEBI:26174
type: Species
initial amount: NaN
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
constant: false

metaM gdp c
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
is: CHEBI:58189
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: GDP
is: C00035
boundary condition: false

metaR HSPASEly
product: MODEL1310110043#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction

metaR r2119
fast: false
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR G12MT1 U
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
type: Reaction
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176

metaR C161CPT22
name: C161 transport into the mitochondria
is described by: ECO:0000269
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reversible: false
modifier: MODEL1310110043#

metaM HC01397 x
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial amount: NaN
constant: false
type: Species
is: CHEBI:27402
has only substance units: false

metaR r0683
is: SBO:0000176
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: false
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3

metaR ORNt3m
type: Reaction
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
name: ornithine mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_7345f25f_664d_4695_9443_7e2d9d508cfe
is: O60701
initial amount: NaN
type: Species
has only substance units: false
name: UGDH
is: SBO:0000252
is encoded by: hsa:7358
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_cb5da8b8_6aed_48ef_b50e_f7e755a72b4a
has only substance units: false
name: AK5
constant: false
type: Species
is encoded by: hsa:26289
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM dlnlcgcrn c
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: HMDB01311
constant: false
is: CHEBI:16004
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: dihomo-gamma-linolenyl carnitine

metaM ksi pre17 g
is: CHEBI:28067
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 17
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
is: SBO:0000247
type: Species

metaM adn c
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: C00212
boundary condition: false
has only substance units: false
is: CHEBI:16335
initial amount: NaN
type: Species
constant: false
is: HMDB00050
initial concentration: 1.0
name: Adenosine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_facb4e39_7d0c_4001_92eb_69a0a416701f
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6342
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: C9JC79
has only substance units: false
name: SCP2

metaR r2118
type: Reaction
reactant: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185

metaM CE5118 m
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
type: Species
initial amount: NaN

metaR CSNAT2m
is described by: ECO:0000000
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
reversible: true
name: carnitine O-aceyltransferase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR IDOAASE1ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
reactant: MODEL1310110043#
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110043#

metaR LYStm
reversible: true
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000269
name: Lysine mitochondrial transport via ornithine carrier
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_87f92d58_556b_4ca0_9a92_1bfc0bd403dd
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:84264
is: SBO:0000252
initial concentration: NaN
name: HAGHL

metaM pmtcoa c
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
is: CHEBI:3454
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false
is: C00154
is: HMDB01338
initial amount: NaN
type: Species
constant: false

metaR ABTArm
reversible: true
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM thf m
initial concentration: 1.0
type: Species
is: CHEBI:57453
is: HMDB01846
constant: false
is: C00101
name: 5,6,7,8-Tetrahydrofolate
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR EX CE1935 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine monoaldehyde exchange
type: Reaction

metaM glyc3p c
initial amount: NaN
is: SBO:0000247
constant: false
name: Glycerol 3-phosphate
type: Species
is: C00093
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
is: HMDB00126
boundary condition: false
has only substance units: false

metaM ksi pre9 g
name: keratan sulfate I biosynthesis, precursor 9
initial concentration: 1.0
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
type: Species
constant: false
boundary condition: false
is: CHEBI:58053
is: C00130
is: HMDB00175
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM gtp e
constant: false
is: CHEBI:37565
name: GTP(4-)
initial amount: NaN
boundary condition: false
is: HMDB01273
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_08568f86_ef5a_4d16_81ea_bfdd123af14e
type: Species
is encoded by: hsa:5476
is: P10619
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: CTSA
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7d0a6b57_ed02_42fe_ab2a_b2ca885a0e87
is: SBO:0000252
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487
is: Q5T4W8
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaR G3PD1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
reactant: MODEL1310110043#
name: glycerol-3-phosphate dehydrogenase (NAD)
product: MODEL1310110043#
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_76013ce8_cbbf_4815_92c5_f6761871dbf9
is encoded by: hsa:AI971036
initial amount: NaN
name: _AI971036_1_c
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM hs deg16 l
is: CHEBI:21338
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: heparan sulfate, degradation product 16
is: HMDB02704
type: Species
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: SBO:0000247
constant: false

metaR FAOXC12DCTc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR RE3367E
reversible: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
is: SBO:0000176
name: RE3367
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction

metaM CE2431 m
is: CHEBI:57795
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: cis-deca-4-enoyl-CoA
initial amount: NaN

metaM 3hpp m
is: CHEBI:16510
is: HMDB00700
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
type: Species
constant: false
name: 3-hydroxypropionate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r0686
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
product: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_f1320fb5_07fe_4c45_8f90_3380074d0787
is encoded by: hsa:AV717590
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: _AV717590_1_m

http://identifiers.org/biomodels.db/MODEL1310110043#_cdf0d3da_ddc7_4740_a38a_33d6e74ca1e4
boundary condition: true
initial amount: NaN
constant: false
name: GALT
type: Species
initial concentration: NaN
is encoded by: hsa:2592
is: SBO:0000252
has only substance units: false
is: B2RAT6

metaM pristcoa c
constant: false
is: CHEBI:51341
boundary condition: false
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: pristanoyl coa

metaR r2538
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Utilized transport
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_e2ee761d_7e5c_45d2_8889_55197e180c5e
initial concentration: NaN
constant: false
name: DBT
is: SBO:0000252
is encoded by: hsa:1629
type: Species
is: P11182
boundary condition: true
has only substance units: false
initial amount: NaN

metaM ethamp r
type: Species
constant: false
name: O-phosphonatoethanaminium(1-)
is: CHEBI:58190
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
is: HMDB00224
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_343a0197_9535_4149_b2d4_9c0dbc26c1fb
type: Species
name: TMEM91
is: C9JZ62
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:641649

metaR RE2660N
reversible: true
name: RE2660
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
type: Reaction

metaR ADK1
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: adenylate kinase
fast: false
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
is described by: ECO:0000269

metaR SADT
kinetic law: MODEL1310110043#
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110043#
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110043#
is: SBO:0000176
type: Reaction

metaR NDP3ex
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is described by: ECO:0000269
reactant: MODEL1310110043#

metaM h c
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
boundary condition: false
name: proton
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110043#_d49e422c_fbed_4275_9e2c_7826d0899545
type: Species
boundary condition: true
name: CEPT1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B3KN25
is encoded by: hsa:10390
constant: false
initial amount: NaN

metaM 10fthf7glu e
has only substance units: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: HMDB00972
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
type: Species

metaM coa c
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Coenzyme A
is: C00010
type: Species
is: HMDB01423
has only substance units: false
is: CHEBI:3312

http://identifiers.org/biomodels.db/MODEL1310110043#_bcebacd1_e48e_4bb3_ba36_f5b5a066b683
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: HADHB
is: P55084
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:3032

metaR NACHEXA5ly
product: MODEL1310110043#
reactant: MODEL1310110043#
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false

metaM xyl D e
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15936
name: aldehydo-D-xylose
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
type: Species
is: SBO:0000247

metaR 3HBCOARc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (R)-3-hydroxybutanoyl-CoA into cytosol
type: Reaction

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR P4502C9
modifier: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1559.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:2827463,PMID:3032244 NOTES:tolbutamide 4 methyl hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.14.13.48
name: cytochrome P450 2C9
reactant: MODEL1310110043#
fast: false

metaR AK2LGCHOLt
is described by: ECO:0000269
kinetic law: MODEL1310110043#
type: Reaction
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_68cbe978_8418_4e9b_8f56_ce43fa1ad762
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: P51178
constant: false
name: PLCD1
is encoded by: hsa:5333
is: SBO:0000252

metaR C204CRNt
reversible: false
name: arachidonic acid transport into the mitochondria
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
is: SBO:0000185

metaR DOPASULT
is described by: ECO:0000269
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110043#
name: Dopamine Sulfotransferase
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_2632c059_7e9a_4430_8a71_abe2b010ebfd
has only substance units: false
is: SBO:0000252
is encoded by: hsa:435
is: E9PE48
constant: false
initial concentration: NaN
boundary condition: true
name: ASL
type: Species
initial amount: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_bbf4878b_254e_40c7_b573_b06bf9849dc6
initial amount: NaN
name: ACADS
boundary condition: true
is: P16219
is: SBO:0000252
has only substance units: false
is encoded by: hsa:35
initial concentration: NaN
constant: false
type: Species

metaM HC01406 m
is: CHEBI:28264
name: 3-Oxooctanoyl-CoA
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_b6fe3930_3e87_4251_8e73_429e2e328b44
type: Species
initial amount: NaN
initial concentration: NaN
is: Q16836
is: SBO:0000252
has only substance units: false
name: HADH
is encoded by: hsa:3033
constant: false
boundary condition: true

metaR RE0689E
is: SBO:0000176
reversible: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: RE0689
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_d0a21e9c_ba5f_4a41_8b9f_185509a9aa15
name: ALDH3B2
type: Species
has only substance units: false
boundary condition: true
constant: false
is: P48448
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:222

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR PUNP6
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#
fast: false
name: purine-nucleoside phosphorylase (Deoxyinosine)
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_f14d8103_b93d_4945_af34_3cd4de52df53
constant: false
initial amount: NaN
type: Species
name: ST3GAL5
is encoded by: hsa:8869
is: Q9UNP4
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR UPPN
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: b-ureidopropionase
modifier: MODEL1310110043#

metaM hdd2coa m
is: SBO:0000247
is: CHEBI:61526
is: HMDB03945
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: C05272
name: trans-Hexadec-2-enoyl-CoA
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0722
reversible: true
type: Reaction
modifier: MODEL1310110043#
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/4.2.3.12
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
fast: false

metaR r1627
fast: false
reversible: true
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaM appnn c
name: (+)-alpha-pinene
constant: false
is: CHEBI:28261
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
is: HMDB06525

metaR DLNLCGCRNt
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: transport into the mitochondria (carnitine)
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_0edd4263_b4fd_4cf4_944c_d5a31c4c60c8
is: A6NN98
is encoded by: hsa:8898
name: MTMR2
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: C00095
type: Species
boundary condition: false
is: HMDB00660
is: CHEBI:15824
has only substance units: false
constant: false

metaM adpac c
name: adipic acid
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H8O4 CHARGE: -2
initial concentration: 1.0
is: HMDB00448
constant: false
has only substance units: false

metaR VITD3t2
is: SBO:0000185
kinetic law: MODEL1310110043#
fast: false
reversible: false
name: Vitamin D3 uptake
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
product: MODEL1310110043#

metaM HC00718 c
is: CHEBI:57781
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaM hpdcacoa m
is: HMDB06497
boundary condition: false
constant: false
name: heptadecanoyl coa
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: SBO:0000247

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaM sbt D e
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00247
initial amount: NaN
is: SBO:0000247
constant: false

metaR PUNP5
name: purine-nucleoside phosphorylase (Inosine)
type: Reaction
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true

metaM 2hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_fccf7ecb_3893_4959_a67c_9ab99fd27203
type: Species
initial amount: NaN
constant: false
is: D9HTE9
initial concentration: NaN
has only substance units: false
name: SLC25A1
is: SBO:0000252
is encoded by: hsa:6576
boundary condition: true

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#

metaM but m
has only substance units: false
initial concentration: 1.0
is: HMDB00039
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
constant: false
is: CHEBI:17968
type: Species
initial amount: NaN

metaR r0723
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110043#
reversible: false
product: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000000

metaR FAOXC102C103x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaM 3sala m
is: CHEBI:61085
boundary condition: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: C00606
name: 3-sulfino-L-alanine (1-)
is: SBO:0000247

metaM 4mzym int1 r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: 4-Methylzymosterol intermediate 1
type: Species
is: HMDB06927
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
initial amount: NaN

metaR G13MT U
is: SBO:0000176
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
product: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.132
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_636bfd1e_abef_47a0_a5a1_5aaad87fc932
name: ME3
boundary condition: true
is: Q6TCH8
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10873
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_a993246a_4412_42fb_beba_20ba73eb4469
initial amount: NaN
initial concentration: NaN
is: Q96H96
is: SBO:0000252
constant: false
name: COQ2
boundary condition: true
is encoded by: hsa:27235
type: Species
has only substance units: false

metaM txa2 r
name: thromboxane A2(1-)
constant: false
is: HMDB01452
boundary condition: false
has only substance units: false
is: CHEBI:57445
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198

metaR ACOX22x
name: acyl-Coenzyme A oxidase 2, branched chain
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.99.3

metaR C81CPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR PUNP4
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyguanosine)

metaR r0450
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110043#
type: Reaction
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_f7abf8ae_93c4_4ba0_a8af_898dddac29f6
type: Species
initial amount: NaN
name: FPGT
is: O14772
initial concentration: NaN
is encoded by: hsa:8790
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR r0720
type: Reaction
kinetic law: MODEL1310110043#
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110043#

metaM lnlncacrn c
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
constant: false
name: alpha-linolenyl carnitine
initial amount: NaN
is: HMDB06319

metaM acgam l
constant: false
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
name: N-acetyl-D-glucosamine
is: CHEBI:17411
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00215

metaR r1629
reactant: MODEL1310110043#
is: SBO:0000185
reversible: true
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110043#
fast: false

metaM appnn e
notes: FORMULA: C10H16 CHARGE: 0 INCHI: InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
name: (+)-alpha-pinene
is: CHEBI:28261
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06525
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: HMDB00174
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:18287

metaM coucoa m
has only substance units: false
name: 4-coumaroyl-CoA(4-)
initial amount: NaN
is: C00223
constant: false
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57355

metaR FAOXC201C181x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_288a9dc8_eb53_4acc_86de_06b06786ff4d
has only substance units: false
initial concentration: NaN
name: PFKP
is: SBO:0000252
constant: false
is: Q5VSR7
is encoded by: hsa:5214
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_d4d8de32_d31f_4b46_84e7_8be4ee2f38fa
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000297
name: SLC7A8:SLC3A2
initial concentration: NaN
constant: false
is encoded by: hsa:23428
has part: Q86U05
initial amount: NaN

metaR FAOXC181C181OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR P4502C8
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (1558.1) or (1558.2) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:paclitaxol 6 alpha hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110043#
is described by: ECO:0000304
name: cytochrome P450 2C8

metaR 3MLDAt
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
is described by: ECO:0000000
product: MODEL1310110043#
name: 3MLDA extracellular transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
fast: false
is: SBO:0000185

metaR PUNP3
kinetic law: MODEL1310110043#
name: purine-nucleoside phosphorylase (Guanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true

metaM sbt D c
is: CHEBI:17924
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00247
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
constant: false

metaR OCDCEAtr
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: true
product: MODEL1310110043#
fast: false
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaR C6CRNtcx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR r2525
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false

metaM xoldiolone c
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:28477
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB02197

metaR DECDPtm
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: true
fast: false

metaM maltpt e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial amount: NaN
is: C02052
is: HMDB01296
name: maltopentaose
constant: false

metaR TMNDNCt
kinetic law: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110043#
reversible: true
name: fatty acid transport via diffusion
is described by: ECO:0000000
type: Reaction

metaR r0242
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110043#
fast: false
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR FBP26
name: Fructose-2,6-bisphosphate 2-phosphatase
product: MODEL1310110043#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.11
is version of: http://identifiers.org/ec-code/2.7.1.105
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF

metaR r1908
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r0726
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
product: MODEL1310110043#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR FAOXTC162TC142m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaR r0456
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reactant: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_8d75bb7a_8d99_41f5_b2bd_acdea3cc12cb
name: ACAT1
is: SBO:0000252
is encoded by: hsa:38
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P24752
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_2aedb330_bd2b_4e6f_929c_95c1e9f656b0
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: SLC27A1
is: SBO:0000252
is encoded by: hsa:376497
boundary condition: true
initial amount: NaN

metaM CE5119 m
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: CHEBI:57923
name: trans-3-cis-8-tetradecadienoyl-CoA
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_809f3c4a_6022_4a8d_b690_4907e5d42d5b
boundary condition: true
name: SLC25A1
type: Species
is: D9HTE9
initial concentration: NaN
is encoded by: hsa:6576
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR 2AMADPTm
fast: false
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
reactant: MODEL1310110043#
is: SBO:0000185
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true

metaM lnlc r
boundary condition: false
name: linoleate
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00673
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial amount: NaN
is: CHEBI:30245
initial concentration: 1.0

metaR SERALANaEx
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
is: SBO:0000185
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#

metaR TYRt
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185
name: L-tyrosine transport
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
fast: false

metaR GLNTHRNaEx
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000185
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)

metaR FAOXC163C164Gm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR ATPH2e
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
name: ATP diphosphohydrolase
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_33185929_eb3a_4f28_8fb5_562d33c4bdb5
is: SBO:0000252
name: FASN
type: Species
constant: false
initial amount: NaN
is: P49327
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2194
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_479ac3b6_c99e_4de4_abff_281279b67a8a
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:7378
name: UPP1
constant: false
is: SBO:0000252
has only substance units: false

metaR r2520
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reactant: MODEL1310110043#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
product: MODEL1310110043#
reversible: true
type: Reaction

metaR B3GNT35g
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110043#
reversible: false
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110043#_fb80f2cb_e305_45b8_8888_6b2ce93d99b5
has only substance units: false
boundary condition: true
name: AGPAT2
is: O15120
constant: false
is encoded by: hsa:10555
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
initial amount: NaN
type: Species
is: HMDB00174
is: CHEBI:18287
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM doco13ecoa c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: 13-docosenoylcoa
is: http://identifiers.org/pubchem.compound/24892791
initial amount: NaN
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
boundary condition: false

metaR r0527
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is described by: ECO:0000000
type: Reaction
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reversible: true

metaM hexdiac r
notes: FORMULA: C16H28O4 CHARGE: -2
is: C08260
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: hexadecanediocacid
is: SBO:0000247
boundary condition: false
is: HMDB00672

metaR FACOAL246 1
modifier: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: fatty-acid--CoA ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR r0724
reversible: true
modifier: MODEL1310110043#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
product: MODEL1310110043#
fast: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR PUNP7
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
reversible: true
name: purine-nucleoside phosphorylase (Xanthosine)
fast: false

metaR SERASNNaEx
product: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is: SBO:0000185

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true
product: MODEL1310110043#
type: Reaction
name: Malate:sulfate antiport, mitochondrial

metaR DOLP Uter
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
name: dolichol phosphate flippase (uterus)
kinetic law: MODEL1310110043#

metaR C3STKR2r
fast: false
name: C-3 sterol keto reductase (zymosterol)
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110043#
is described by: ECO:0000134
product: MODEL1310110043#
reversible: false

metaR TYMSFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
is: SBO:0000185
name: Tyramine O-sulfate transport (diffusion)
reversible: false
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
type: Reaction

metaR THRGLNexR
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a4976d17_bfff_40df_ac35_4b5fc66903a2
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: SLC4A3
is encoded by: hsa:6508
is: SBO:0000252

metaM h x
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
is: CHEBI:24636
has only substance units: false
is: SBO:0000247
type: Species
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
is: C00080

metaR FAOXC18C18OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR r1907
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_76f7e47d_b5b3_4432_8968_f7e5af63a34c
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:R39999
has only substance units: false
initial concentration: NaN
name: _R39999_1_c

http://identifiers.org/biomodels.db/MODEL1310110043#_d6e2abcd_eaa5_4212_ac27_a739e290f92b
initial amount: NaN
boundary condition: true
has part: O15254
is encoded by: hsa:8310
type: Species
initial concentration: NaN
is: SBO:0000297
has only substance units: false
constant: false
name: EHHADH:ACAA1:HSD17B4:ACOX3

metaR r2521
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
name: Utilized transport
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_8f3d034d_6afb_499b_9f73_8e37a2ca4386
is encoded by: hsa:10965
initial amount: NaN
name: ACOT2
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P49753
constant: false
boundary condition: true

metaR r0679
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110043#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#

metaR FAOXC101m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_21961b1e_b051_42f4_bfd6_5c1cb05cd2ab
initial concentration: NaN
boundary condition: true
type: Species
is: O95139
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: NDUFB6
is encoded by: hsa:4712

metaR FERO
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
fast: false
name: ferroxidase

metaM acald r
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
name: acetaldehyde
type: Species
is: CHEBI:15343
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM c4dc e
is: http://identifiers.org/pubchem.compound/213144
type: Species
has only substance units: false
is: C02862
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H18NO6 CHARGE: -1
is: HMDB02013
boundary condition: false
name: succinyl carnitine
constant: false
initial amount: NaN

metaM acgam r
boundary condition: false
has only substance units: false
is: HMDB00215
name: N-acetyl-D-glucosamine
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17411
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

http://identifiers.org/biomodels.db/MODEL1310110043#_661a411e_8246_491b_8215_630ffdfd1c30
has only substance units: false
initial concentration: NaN
constant: false
name: _H17063_1_m
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:H17063
boundary condition: true

metaR r0246
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110043#
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2

metaR TETTET6COAtx
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
product: MODEL1310110043#
name: fatty acid intracellular transport
is: SBO:0000185
reversible: true

metaR BUTt2r
modifier: MODEL1310110043#
name: Butyrate transport via proton symport, reversible
is described by: ECO:0000269
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
fast: false

metaR r0835
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110043#

metaM ru5p D r
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
constant: false
name: D-ribulose 5-phosphate(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaM stcrn c
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
initial concentration: 1.0
is: HMDB00848
name: stearoylcarnitine

metaM c101crn c
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
name: decenoyl carnitine
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM but c
initial amount: NaN
boundary condition: false
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
initial concentration: 1.0
has only substance units: false
is: HMDB00039
type: Species
constant: false
is: SBO:0000247

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR GLCAASE8ly
reversible: false
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110043#

metaR PA HSter
reversible: true
fast: false
is: SBO:0000185
name: phosphatidate scramblase
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3617cee1_1244_43e0_b944_aff2f96ae8cf
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1375
is: SBO:0000252
is: E9PCP2
name: CPT1B
has only substance units: false

metaM hexdiac c
name: hexadecanediocacid
is: SBO:0000247
is: C08260
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_9551d7e0_4414_4903_882d_60c97b789636
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57194
constant: false
is: O60312
is: SBO:0000252
initial amount: NaN
name: ATP10A
has only substance units: false
type: Species

metaM cspg b e
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
boundary condition: false
is: HMDB00630
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:16040
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_4eba3226_9dfc_41ad_9772_4dae8852a57d
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4720
initial amount: NaN
name: NDUFS2
type: Species
has only substance units: false
is: B7Z792
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_5305d155_628d_464e_8341_96474033ff66
initial concentration: NaN
name: ATP5F1
initial amount: NaN
is encoded by: hsa:515
is: P24539
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR RDH3
product: MODEL1310110043#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
type: Reaction
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: retinol dehydrogenase (11-cis,NADH)
is described by: ECO:0000269
reactant: MODEL1310110043#

metaR r0245
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

metaR r1620
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#

metaM vacc c
is: C08367
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
name: trans-vaccenate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828

metaM sql r
type: Species
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:15440
is: HMDB00256
initial amount: NaN
name: squalene
has only substance units: false
boundary condition: false

metaR PROSTGH2t
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110043#
name: Prostaglandin H2 transport
reactant: MODEL1310110043#
product: MODEL1310110043#

metaR GLYtm
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
name: glycine passive transport to mitochondria

metaM h n
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: CHEBI:24636
type: Species
is: SBO:0000247
constant: false

metaR FTHFL
name: Formate-tetrahydrofolate ligase
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR ITCOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000212
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
modifier: MODEL1310110043#
product: MODEL1310110043#

metaR ECOAH12m
product: MODEL1310110043#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110043#
reversible: true
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR DDPGAm
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
is described by: ECO:0000000

metaR r0523
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000000
type: Reaction

metaR FAOXC200180m
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000

metaR FUMSO3tm
reactant: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
name: Fumarate:sulfite antiport, mitochondrial
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR FAOXC102C103m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR r1621
fast: false
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM hs l
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
has only substance units: false
initial concentration: 1.0
name: heparan sulfate, free chain
initial amount: NaN
is: CHEBI:28815
constant: false

metaR URIt
reversible: true
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
name: uridine facilated transport in cytosol
is: SBO:0000185
modifier: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269

metaM c101crn e
is: SBO:0000247
constant: false
type: Species
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
has only substance units: false
name: decenoyl carnitine
initial concentration: 1.0

metaR APPNNte
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
reversible: true
reactant: MODEL1310110043#
name: xenobiotic transport
product: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction

metaM h m
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:24636
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080

metaR r0522
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110043#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#
type: Reaction

metaR r0834
reversible: true
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR ACNAMPH
fast: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f6e519ca_4b73_4e24_bd29_be0f70a2098e
is encoded by: hsa:23657
initial amount: NaN
boundary condition: true
has part: Q9UPY5
is: SBO:0000297
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: SLC7A11:SLC3A2

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110043#
product: MODEL1310110043#

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM adp r
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
has only substance units: false
is: HMDB01341
name: ADP(3-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:456216
type: Species
constant: false

metaR TSTSTERONESULT
reversible: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
fast: false
name: testosterone sulfotransferase
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
type: Reaction
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_33c672d9_79cc_43ea_99e0_9536d0f4e740
is: Q5JT09
type: Species
name: UCK1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:83549
boundary condition: true
constant: false

metaM vacc e
is: CHEBI:30828
boundary condition: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial concentration: 1.0
is: SBO:0000247
name: trans-vaccenate
type: Species
constant: false
initial amount: NaN

metaM lnlncacrn m
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
type: Species
is: HMDB06319
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: alpha-linolenyl carnitine
is: SBO:0000247

metaM tchola c
constant: false
initial amount: NaN
is: HMDB00036
has only substance units: false
type: Species
name: taurocholic acid
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
is: SBO:0000247

metaM h l
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: CHEBI:24636
type: Species
has only substance units: false
is: SBO:0000247

metaR CYTK9n
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR r1623
modifier: MODEL1310110043#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110043#

metaR DNDPt29m
product: MODEL1310110043#
type: Reaction
fast: false
kinetic law: MODEL1310110043#
name: dCDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
reversible: false
is: SBO:0000185

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_00ee0d5c_2d34_45c6_874c_381cf4131718
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AK2
type: Species
constant: false
is encoded by: hsa:204

metaM dcyt c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
is: SBO:0000247
name: Deoxycytidine
is: CHEBI:15698
constant: false
is: HMDB00014
has only substance units: false
is: C00881

metaM 2hexdtetcoa x
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
type: Species
boundary condition: false
name: 2,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR FE3MTP1
fast: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: transport of ferrous iron into blood
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reversible: false
is: SBO:0000185

metaR DGSNtm
name: deoyguanosine transport in mitochondria
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110043#

metaR PUNP2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110043#
fast: false
name: purine-nucleoside phosphorylase (Deoxyadenosine)
kinetic law: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: true

metaR CARPEPT1tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM dgdp c
name: dGDP
is: HMDB00960
is: SBO:0000247
is: C00361
initial amount: NaN
is: CHEBI:58595
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

metaM icit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00193
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Isocitrate
is: CHEBI:16087
is: C00311
type: Species

metaR 2OXOADPTm
product: MODEL1310110043#
reversible: true
is: SBO:0000185
type: Reaction
name: 2-oxoadipate shuttle (cytosol/mitochondria)
modifier: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
kinetic law: MODEL1310110043#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_379127f9_81a0_4d5e_8714_ed43d893139f
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: PRDX1
is encoded by: hsa:5052
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110043#_a4c381d8_5b2c_4ad1_8725_c921428c753f
type: Species
is encoded by: hsa:10423
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: CDIPT
constant: false
is: A8K3L7
initial amount: NaN
boundary condition: true

metaR BUTt2m
kinetic law: MODEL1310110043#
name: Butyrate mitochondrial transport via proton symport, reversible
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110043#_f1b47043_e826_4e5a_ba90_42b84d12851a
is: SBO:0000252
is encoded by: hsa:AI469183
initial amount: NaN
initial concentration: NaN
type: Species
name: _AI469183_1_x
boundary condition: true
constant: false
has only substance units: false

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r1624
reversible: true
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_3a0d82e8_5367_479f_815c_85d9b82388c7
constant: false
initial concentration: NaN
is encoded by: hsa:3038
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: HAS3
is: Q96RV2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_e4df54da_9ca6_473d_8f41_3765ba9fdd0a
constant: false
type: Species
is encoded by: hsa:5625
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: O43272
is: SBO:0000252
boundary condition: true
name: PRODH

metaR r0249
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
reversible: true
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
kinetic law: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#

metaR FAOXC225m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM h r
is: C00080
is: CHEBI:24636
is: SBO:0000247
initial amount: NaN
name: proton
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
has only substance units: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3380

metaR EX taxol LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: paclitaxel exchange
type: Reaction

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR PUNP1
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
name: purine-nucleoside phosphorylase (Adenosine)
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9932824d_52ed_4761_80ca_5e0fdb645a45
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:23533
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000297
name: PIK3R5:PIK3CG
has part: Q8WYR1

http://identifiers.org/biomodels.db/MODEL1310110043#_395b1ce4_aa58_49ef_b7c4_058babcc6a18
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: Q8WUX1
is encoded by: hsa:92745
boundary condition: true
name: SLC38A5

http://identifiers.org/biomodels.db/MODEL1310110043#_4f85c4e3_1093_4b78_ad34_beccd125096f
is: SBO:0000252
constant: false
initial amount: NaN
name: SHMT1
is: P34896
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6470

metaM tchola e
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0
initial amount: NaN
is: HMDB00036
initial concentration: 1.0
name: taurocholic acid
has only substance units: false

metaM am6sa c
is: HMDB01280
is: CHEBI:57495
type: Species
initial concentration: 1.0
notes: FORMULA: C6H7NO3 CHARGE: 0 INCHI: InChI=1S/C6H7NO3/c7-5(6(9)10)3-1-2-4-8/h1-4H,7H2,(H,9,10)/p-1/b2-1-,5-3+ HEPATONET_1.0_ABBREVIATION: HC01186 EHMN_ABBREVIATION: C03824
name: 2-aminomuconate 6-semialdehyde(1-)
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR r1625
is: SBO:0000185
modifier: MODEL1310110043#
reversible: true
type: Reaction
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM c4dc c
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
is: C02862
constant: false
is: HMDB02013
name: succinyl carnitine
is: SBO:0000247
type: Species
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false

metaR RDH2
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
name: retinol dehydrogenase (9-cis,NADH)
reactant: MODEL1310110043#
reversible: true
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_93bd64ee_3d67_483a_b216_693766351e63
type: Species
name: _BE966236_1_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:BE966236
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_436d120f_6783_4711_91a9_7bb39983b136
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: BCKDHB
is: SBO:0000252
constant: false
is: P21953
is encoded by: hsa:594

metaM HC01609 e
name: UroporphyrinogenI
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28766
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
type: Species
constant: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM ksi pre14 g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 14
type: Species
boundary condition: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial amount: NaN
is: CHEBI:28067

metaM val L m
is: CHEBI:16414
boundary condition: false
type: Species
is: HMDB00883
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_967c7b9c_e238_49bc_87d7_6919892544e8
is: Q96IJ6
name: GMPPA
is encoded by: hsa:29926
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9ff9d64d_ecc4_4e1a_a66c_7515aaab51ec
name: GAMT
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2593
type: Species

metaM adrn e
is: SBO:0000247
name: adrenic acid
boundary condition: false
initial concentration: 1.0
is: HMDB02226
type: Species
has only substance units: false
is: CHEBI:53487
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
constant: false

metaM HC00460 c
has only substance units: false
constant: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 2,5-dihydroxybenzoate
is: CHEBI:58044

metaR PTCRTD
name: diffusion of putriscine into the endothelial cells
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
is: SBO:0000185
reversible: true

metaM 2decdicoa m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
type: Species
constant: false
name: 2,7-decadienoylcoa

metaM but e
name: butyrate
is: CHEBI:17968
boundary condition: false
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR B3GNT12g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
kinetic law: MODEL1310110043#
is described by: ECO:0000269
fast: false
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
product: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176

metaM ala L m
is: HMDB00161
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: L-alanine
is: CHEBI:16977
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_2a5c8f04_8c11_4991_9742_3a266b515461
boundary condition: true
is: C7ECU1
initial concentration: NaN
is: SBO:0000252
name: ACE2
has only substance units: false
is encoded by: hsa:59272
constant: false
initial amount: NaN
type: Species

metaR r1626
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR RDH1
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
name: retinol dehydrogenase (all-trans)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
type: Reaction
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR BCDO
notes: GENE_ASSOCIATION: (53630.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.14.99.36 Confidence Level: 4 AUTHORS: PMID:10799297,PMID:11401432,PMID:1503811 NOTES:IT
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.99.36
is: SBO:0000176
fast: false
product: MODEL1310110043#
type: Reaction
reversible: false
name: beta-Carotene dioxygenase
modifier: MODEL1310110043#
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_87263cfa_d13e_49ba_b16a_ac6572f4e77c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1798
name: DPAGT1
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: Q9H3H5

metaM hpdcacoa c
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: heptadecanoyl coa
constant: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial concentration: 1.0
is: HMDB06497
type: Species

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR GGH 6DHFe
reactant: MODEL1310110043#
is: SBO:0000176
reversible: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is described by: ECO:0000000

metaR r0830
is: SBO:0000185
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
fast: false
modifier: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR PSt3
type: Reaction
name: phosphatidylserine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110043#
reversible: true

metaR GLCAASE9ly
product: MODEL1310110043#
type: Reaction
name: beta-glucuronidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reversible: false

metaR O2St
is: SBO:0000185
fast: false
product: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
name: superoxide anion transport via diffusion (extracellular)
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_bf073e5f_4d83_4c08_9285_8c9efaf4d713
type: Species
is encoded by: hsa:4905
initial concentration: NaN
name: NSF
boundary condition: true
is: P46459
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
is: HMDB02281
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_987e667c_fc2d_47b6_84c3_27fd4f43a274
is encoded by: hsa:284273
initial concentration: NaN
name: ZADH2
is: Q4G1C4
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR 3MOPte
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxopentanoate
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110043#

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR DOLASNT Uer
is version of: http://identifiers.org/ec-code/2.4.1.119
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
modifier: MODEL1310110043#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_1bddb619_d35d_4815_8a50_9ba8c7f3fbc9
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:476
is: B7Z3U6
constant: false
is: SBO:0000252
boundary condition: true
name: ATP1A1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_859ce3e2_bbba_4238_9881_e214ee5d1cb3
type: Species
name: ADO
is encoded by: hsa:84890
initial amount: NaN
is: B3KXN9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_f9e058a8_6bbe_471d_a5fb_5107381a0938
boundary condition: true
constant: false
is encoded by: hsa:4540
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ND5
is: P03915

http://identifiers.org/biomodels.db/MODEL1310110043#_94bd24f6_fffa_441b_8243_8ed0e23229d1
initial amount: NaN
boundary condition: true
is encoded by: hsa:286297
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: _286297_1_c
initial concentration: NaN

metaR DNDPt36m
reversible: false
product: MODEL1310110043#
is: SBO:0000185
fast: false
name: dGDP transport via dCDP antiport
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110043#_107afc53_9137_4840_8a5a_aa7eba528a19
is: Q9H936
constant: false
is encoded by: hsa:79751
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC25A22

metaR COAtm
is described by: ECO:0000269
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
name: CoA transporter
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#

metaR r0027
reversible: true
is: SBO:0000176
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110043#
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_58dd1899_275c_4f74_a304_e749cc02ca82
boundary condition: true
type: Species
name: COX7A2L
has only substance units: false
is: Q6FGA0
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9167
initial concentration: NaN

metaR r2105
is: SBO:0000185
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 34hpp m
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:36242
is: HMDB00707

http://identifiers.org/biomodels.db/MODEL1310110043#_28963ab9_dbab_4004_a3dd_0db4a4357c33
initial concentration: NaN
has only substance units: false
name: _AI291895_1_c
is encoded by: hsa:AI291895
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM hexdicoa x
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: hexadecanedioylcoa
is: HMDB03932
type: Species
is: C05258
initial concentration: 1.0

metaR DM pnto R
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for (R)-Pantothenate
type: Reaction

metaR CEPTE
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.2
reversible: false
reactant: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
type: Reaction
name: ethanolamine phosphotransferase
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM CE0713 m
initial concentration: 1.0
type: Species
is: CHEBI:30623
constant: false
is: HMDB02329
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 3-oxolinoleoyl-CoA
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713

http://identifiers.org/biomodels.db/MODEL1310110043#_3f7305fc_8296_47d5_8a83_e30b014ec02a
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:1606
initial concentration: NaN
name: DGKA
is: P23743
has only substance units: false

metaM adrn c
is: SBO:0000247
constant: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: CHEBI:53487
has only substance units: false
type: Species
boundary condition: false
is: HMDB02226
name: adrenic acid
initial concentration: 1.0

metaM eicostet e
notes: FORMULA: C20H31O2 CHARGE: -1
constant: false
boundary condition: false
has only substance units: false
is: HMDB02177
initial concentration: 1.0
initial amount: NaN
is: CHEBI:36033
type: Species
name: eicosatetranoic acid
is: SBO:0000247

metaR FAOXC204C184m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR C181CRNt
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: C181 transport into the mitochondria
reactant: MODEL1310110043#

metaR TSTSTERONEt
fast: false
reversible: true
name: Testosterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000269
type: Reaction

metaM leuktrE4 e
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:57462
name: leukotriene E4(1-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
is: HMDB02200

http://identifiers.org/biomodels.db/MODEL1310110043#_0b43c42b_e487_4ee8_86d5_ce8cfd70b4ef
initial concentration: NaN
is: B2R6S5
constant: false
name: CMPK1
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:51727
has only substance units: false
is: SBO:0000252

metaR r1401
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.7.10.1
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
product: MODEL1310110043#
fast: false
reversible: false

metaR COAtn
kinetic law: MODEL1310110043#
name: coenzyme A transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110043#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185

metaM oxa m
initial concentration: 1.0
is: CHEBI:30623
has only substance units: false
name: oxalate(2-)
is: SBO:0000247
is: HMDB02329
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
constant: false
initial amount: NaN

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110043#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_71784749_1b54_460a_857e_0164cc27c081
name: HSD17B4
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: E9PB82
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110043#_25b1029b_d229_4dd8_8128_a55c2c23eba5
has only substance units: false
has part: P18545
constant: false
is encoded by: hsa:5148
boundary condition: true
is encoded by: hsa:5147
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
has part: O43924
type: Species

metaR 4MPTNLtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
name: 4-methylpentanal transport (mitochondria)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_d0db278e_e22d_4083_a761_b53d1777a406
has only substance units: false
is: P10696
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:251
name: ALPPL2
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8dfd42e5_c25f_4f41_8763_671dc8caf3f5
has part: P22392
has part: P15531
boundary condition: true
type: Species
name: NME1:NME2
initial amount: NaN
constant: false
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4830
is encoded by: hsa:4831

metaR THYMt
name: thymine reversible transport via facilated diffusion
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_c959f2cf_43d5_4494_b3a4_ff04dfe256d6
name: COQ7
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10229
is: Q99807

metaM HC02208 e
constant: false
type: Species
name: prostaglandin-d1
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: CHEBI:27696
is: SBO:0000247
boundary condition: false

metaM gdpfuc c
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01095
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: GDP-L-fucose(2-)
is: CHEBI:57984

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r2103
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaM CE5160 r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
has only substance units: false
constant: false
name: 3-oxo-cis-9-octadecenoyl-CoA

metaR HEXDICOAACBP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR G14T4g
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
type: Reaction
fast: false

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR r2102
product: MODEL1310110043#
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction

metaM lgt S c
boundary condition: false
initial concentration: 1.0
is: CHEBI:57474
has only substance units: false
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
initial amount: NaN
constant: false
is: HMDB01066
type: Species
name: (R)-S-lactoylglutathionate(1-)
is: SBO:0000247

metaR PMEVKc
is described by: ECO:0000134
product: MODEL1310110043#
name: phosphomevalonate kinase, cytosol
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.2

http://identifiers.org/biomodels.db/MODEL1310110043#_901d7b01_28f0_42b1_a553_4a4e1a933140
name: ADH1B
is: P00325
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:125
constant: false
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8a682f87_6ed7_44a2_878d_e48ece47ca88
initial amount: NaN
boundary condition: true
has only substance units: false
is: P11168
type: Species
name: SLC2A2
is encoded by: hsa:6514
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r0829
fast: false
product: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.37

metaM doco13ecoa x
is: SBO:0000247
name: 13-docosenoylcoa
type: Species
constant: false
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
initial amount: NaN
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM cspg b l
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB02183
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: CHEBI:36005
constant: false
initial concentration: 1.0

metaR ALACYSNaEx
type: Reaction
product: MODEL1310110043#
modifier: MODEL1310110043#
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaR COAtl
product: MODEL1310110043#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
name: CoA transport in lysosome via diffusion
is described by: ECO:0000000
is: SBO:0000185

metaR GLNALANaEx
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
fast: false
kinetic law: MODEL1310110043#

metaR ARACHDt2
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
product: MODEL1310110043#
name: fatty acid transport via diffusion
reversible: true
is described by: ECO:0000000

metaR BTNt2
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reversible: true
name: Biotin reversible transport via proton symport
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#

metaM octa e
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:25646
is: C06423
boundary condition: false
type: Species
name: octanoate (n-C8:0)
is: SBO:0000247
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
has only substance units: false

metaR r2101
type: Reaction
kinetic law: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_110eed4f_9d66_44de_b232_047a4b03e880
boundary condition: true
is: P36969
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: GPX4
initial amount: NaN
is encoded by: hsa:2879

metaR PGLer
type: Reaction
name: 6-phosphogluconolactonase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110043#
reversible: false
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_28393e43_d00c_4cae_891a_21cce4418d4f
name: TKTL1
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:8277
is: B7Z7I0

metaM sgalside hs l
boundary condition: false
is: CHEBI:16349
type: Species
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
is: HMDB00904
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaM 3tetd7ecoa m
constant: false
is: HMDB05066
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false

metaM thbpt4acam c
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
constant: false
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
boundary condition: false
is: HMDB02281

metaM ksi pre16 g
initial amount: NaN
type: Species
is: CHEBI:58053
constant: false
is: C00130
boundary condition: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 16
is: HMDB00175
is: SBO:0000247

metaM ksi deg22 l
is: CHEBI:16953
is: HMDB00812
initial amount: NaN
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
name: keratan sulfate I, degradation product 22
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

metaR r1090
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_9b4064a8_9d56_4bec_9212_bc260ba49c0c
initial amount: NaN
is: Q9H845
constant: false
name: ACAD9
is: SBO:0000252
is encoded by: hsa:28976
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR DUTPDPn
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.23
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000269
name: dUTP diphosphatase, nuclear
reversible: false
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:

metaM Ser Gly Ala X Gly l
boundary condition: false
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
name: protein-linked serine residue (glycosaminoglycan attachment site)
has only substance units: false
initial concentration: 1.0
is: CHEBI:36005
is: SBO:0000247
type: Species
is: HMDB02183
constant: false

metaM ala L c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
name: L-alanine
is: CHEBI:16977
constant: false
initial concentration: 1.0
type: Species
is: HMDB00161
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR RE1691M
modifier: MODEL1310110043#
name: RE1691
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.8.1.1
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

metaM f1p c
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
has only substance units: false
is: SBO:0000247
is: HMDB01076
boundary condition: false
is: C01094
name: D-Fructose 1-phosphate
initial amount: NaN
type: Species
is: CHEBI:18105

metaM c10crn e
is: HMDB00651
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: decanoyl carnitine
notes: FORMULA: C17H33NO4 CHARGE: 0
type: Species

metaR r2100
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_6698b9f5_a907_4e90_9137_d6b8ecf43d36
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:10965
is: P49753
has only substance units: false
initial amount: NaN
name: ACOT2
type: Species
boundary condition: true

metaR PPItx
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110043#
name: Diphosphate transporter, peroxisome
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_85c351fa_5fe2_40f1_b960_c137c20ee7db
initial concentration: NaN
type: Species
is: Q9BV79
has only substance units: false
constant: false
boundary condition: true
name: MECR
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51102

http://identifiers.org/biomodels.db/MODEL1310110043#_a883338a_c581_445b_a986_971dd0e7cf3f
constant: false
is encoded by: hsa:79623
initial amount: NaN
is: SBO:0000252
is: Q96FL9
boundary condition: true
name: GALNT14
has only substance units: false
initial concentration: NaN
type: Species

metaR COAtr
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
name: COA transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM 4mop m
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
type: Species
has only substance units: false
constant: false
is: HMDB00695
initial amount: NaN
is: CHEBI:17865
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

http://identifiers.org/biomodels.db/MODEL1310110043#_9dd61af6_83eb_41ec_905f_6f48201c5e23
initial amount: NaN
name: HIBCH
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:26275
is: Q6NVY1

http://identifiers.org/biomodels.db/MODEL1310110043#_b66b4258_4b2a_4f4b_91c7_73c55f989e13
constant: false
boundary condition: true
has only substance units: false
is: Q01968
is encoded by: hsa:4952
is: SBO:0000252
type: Species
initial amount: NaN
name: OCRL
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_4379c018_f5ff_4347_b1e1_b39e663192d4
initial amount: NaN
name: SLC25A26
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:115286
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b627d29d_f399_4a3a_89bc_3b1699947cd7
has part: P38117
has only substance units: false
is: SBO:0000297
name: ETFA:ETFB
is encoded by: hsa:2109
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_2d9635b5_f41c_432e_ba89_36fdd94d4ba2
type: Species
constant: false
name: PANK1
boundary condition: true
is encoded by: hsa:53354
is: Q8TE04
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM hdd2coa x
name: (E)-hexadec-2-enoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
is: HMDB03945

metaM dgdp m
is: HMDB00960
is: CHEBI:58595
is: SBO:0000247
initial amount: NaN
name: dGDP(2-)
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
has only substance units: false

metaR CSNAT3x
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-aceyltransferase, peroxisomal
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_8268ec05_9779_4a0f_9c5f_ba9475cc794d
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P53396
initial concentration: NaN
is encoded by: hsa:47
name: ACLY

metaM ha deg1 l
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1
name: hyaluronan degradation product 1
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16336

metaR RAI2
product: MODEL1310110043#
reversible: true
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000

metaM lneldc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06270
initial amount: NaN
name: linoelaidic acid (all trans C18:2)
boundary condition: false

metaR S6T18g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reversible: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR OCOAT1m
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
name: 3-oxoacid CoA-transferase
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.3.5
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
reversible: true

metaM ala L e
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
is: CHEBI:16977
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: L-alanine
is: HMDB00161

metaM ksii core2 deg5 l
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
type: Species
notes: FORMULA: C50H82N4O38SX CHARGE: -1
initial amount: NaN
is: CHEBI:12936
is: HMDB00143

metaR CMPACNAtg
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
name: CMP-Sia Golgi transport via CMP antiport
reversible: true
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#

metaM ksi pre30 g
name: keratan sulfate I biosynthesis, precursor 30
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
is: C00130
initial concentration: 1.0
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: SBO:0000247
boundary condition: false

metaM sbcoa c
is: SBO:0000247
boundary condition: false
name: suberylcoa
type: Species
initial concentration: 1.0
is: C02838
has only substance units: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: HMDB00791
initial amount: NaN
constant: false

metaR H6ET3er
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
modifier: MODEL1310110043#
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/2.7.8.1
reactant: MODEL1310110043#
type: Reaction

metaR COAtp
name: coenzyme A transport, peroxisomal
product: MODEL1310110043#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM leuktrE4 c
has only substance units: false
boundary condition: false
name: leukotriene E4(1-)
initial amount: NaN
is: CHEBI:57462
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
is: HMDB02200
type: Species

metaM xol7ah3 m
is: CHEBI:28540
is: SBO:0000247
has only substance units: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_913dc0ab_ab7b_47d4_a4df_449417344f9f
has only substance units: false
is encoded by: hsa:224
constant: false
initial amount: NaN
type: Species
name: ALDH3A2
initial concentration: NaN
is: P51648
is: SBO:0000252
boundary condition: true

metaR GALASE15ly
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
product: MODEL1310110043#
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR FAOXC225x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_4089ac63_f0b0_42e9_92e1_b656da4d9707
is: P34059
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2588
initial concentration: NaN
has only substance units: false
type: Species
name: GALNS
constant: false
initial amount: NaN

metaM dgdp n
constant: false
type: Species
is: HMDB00960
is: CHEBI:58595
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a9ab5b38_f1d5_4aea_8b83_ced5656bc4a4
is: P51857
name: AKR1D1
is encoded by: hsa:6718
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_02a0bcef_0305_49ae_bde3_2f7a3a1f96fc
is: Q9NWU1
is encoded by: hsa:54995
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: OXSM
initial concentration: NaN

metaR PSDm hs
is described by: ECO:0000269
modifier: MODEL1310110043#
product: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.65
reversible: false
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_7879d270_44eb_4925_b48c_9709258f6c26
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9H008
type: Species
is encoded by: hsa:64077
name: LHPP
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_f251dd98_6cbe_45f1_b90c_d1e82fe3a3ca
is: SBO:0000252
initial concentration: NaN
is: O00624
constant: false
name: SLC17A2
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10246

metaM lneldc c
is: SBO:0000247
initial amount: NaN
is: HMDB06270
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
name: linoelaidic acid (all trans C18:2)

metaM 34hpp e
name: 3-(4-hydroxyphenyl)pyruvate
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36242
constant: false
is: HMDB00707
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a257bd60_2e12_4428_a5e9_5b74471361cd
is encoded by: hsa:197258
type: Species
boundary condition: true
constant: false
name: FUK
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q8N0W3

http://identifiers.org/biomodels.db/MODEL1310110043#_46d74fd8_e2e9_4a5c_9b96_eec0dbdf5b26
is encoded by: hsa:5464
initial concentration: NaN
type: Species
name: PPA1
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q15181
boundary condition: true

metaM dcyt n
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
boundary condition: false
initial amount: NaN
name: 2'-deoxycytidine
constant: false
is: CHEBI:15698
is: HMDB00014
has only substance units: false
is: SBO:0000247

metaR HDCEAtr
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110043#
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
reactant: MODEL1310110043#

metaR C161CPT12
modifier: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false

metaM cholcoads x
is: SBO:0000247
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
has only substance units: false
initial amount: NaN
is: CHEBI:27505
is: HMDB06889
boundary condition: false
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
constant: false

metaM tag hs c
initial amount: NaN
is: CHEBI:17855
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
constant: false
type: Species
name: triglyceride
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_1fe312cd_d92b_4996_8158_586956e90e96
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:221823
is: P21108
boundary condition: true
constant: false
name: PRPS1L1
type: Species
initial concentration: NaN

metaR GLCAASE7ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110043#
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_7caa5621_8cbf_4ab7_b902_70e91132d449
name: GPAM
has only substance units: false
is: Q8N1G6
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:57678
boundary condition: true

metaM oxa e
type: Species
constant: false
name: oxalate(2-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
boundary condition: false
is: HMDB02329
is: CHEBI:30623

metaR RAI1
reversible: true
product: MODEL1310110043#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110043#
fast: false
name: retinal isomerase (11-cis)

metaM undcoa m
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: undecanoylcoa
is: HMDB13114

metaR ATPS4m
reversible: false
reactant: MODEL1310110043#
is described by: ECO:0000134
product: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.14
is: SBO:0000185
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
name: ATP synthase (four protons for one ATP)
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.6
is version of: http://identifiers.org/ec-code/3.6.1.14

http://identifiers.org/biomodels.db/MODEL1310110043#_03feb0c8_bafd_4fc0_b611_7d1d6a8d0dfe
initial concentration: NaN
is: Q9H999
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:79646
name: PANK3

http://identifiers.org/biomodels.db/MODEL1310110043#_9c4bb235_90da_4b29_b231_9bad02b3f527
name: PLCB1
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q9NQ66
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23236

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_bb22ed6e_5201_4487_b247_832b24333761
is encoded by: hsa:23539
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: SLC16A8
is: SBO:0000252
boundary condition: true
is: O95907
has only substance units: false

metaR r0718
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.1.1.181
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
type: Reaction

metaR DCTPtn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: dCTP diffusion in nucleus

http://identifiers.org/biomodels.db/MODEL1310110043#_372c91a8_e365_4dd7_a777_72e7bca7ff0e
is encoded by: hsa:83733
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: SLC25A18
constant: false
is: Q9H1K4
boundary condition: true

metaR ALAGLNNaEx
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
is: SBO:0000185
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR OCTAt
kinetic law: MODEL1310110043#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110043#
name: Octanoate transport via diffusion
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110043#
type: Reaction

metaR LAPCOAe
kinetic law: MODEL1310110043#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: LAPCOAe
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
reversible: false

metaM Nacasp m
is: HMDB00812
name: N-acetyl-L-aspartate(2-)
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16953
boundary condition: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
is: SBO:0000247

metaR UGALNACtg
is: SBO:0000185
name: UDP-GalNAc Golgi transport via CMP antiport
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM carn e
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: carnosine
is: CHEBI:15727
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
is: HMDB00033

metaR r0670
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
fast: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_5f9261e7_6566_456a_ab58_eb3109a7c46a
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9UN76
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:11254
name: SLC6A14

metaR GALASE12ly
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110043#

metaM CE4792 m
constant: false
type: Species
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57923
name: 3-oxo-cis-8-tetradecenoyl-CoA
has only substance units: false
is: SBO:0000247

metaM 3sala c
is: C00606
name: 3-Sulfino-L-alanine
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:61085
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR 4HOXPACDOX NADP
kinetic law: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110043#
is described by: ECO:0000304
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction

metaM 34hpp c
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00707

metaM ksi deg35 l
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
constant: false
type: Species
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
boundary condition: false
name: keratan sulfate I, degradation product 35
initial amount: NaN

metaR r0717
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_5e1b0c22_2c19_48f3_aceb_8e8f0234064b
has only substance units: false
is: B4DK61
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: ACOX1
initial concentration: NaN
is encoded by: hsa:51
boundary condition: true

metaR LTA4H
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000134
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.3.2.6
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
name: Leukotriene A-4 hydrolase
is: SBO:0000176
kinetic law: MODEL1310110043#
type: Reaction

metaR LPCHOLt
product: MODEL1310110043#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
name: lysophosphatidylcholine transport

metaR EICOSTETCPT1
is described by: ECO:0000269
reversible: false
type: Reaction
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM octa c
name: octanoate (n-C8:0)
is: SBO:0000247
type: Species
is: C06423
boundary condition: false
is: HMDB00482
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646

metaM adpac x
initial concentration: 1.0
name: adipic acid
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN
type: Species
is: HMDB00448

metaM dctp n
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
is: SBO:0000247
has only substance units: false
is: CHEBI:16311
is: HMDB00998
initial amount: NaN
type: Species
name: dCTP
boundary condition: false

metaM tag hs e
name: triglyceride
is: CHEBI:17855
type: Species
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_cf2d5759_2b2b_43d7_a31b_86c87e1a0bed
initial amount: NaN
name: PEMT
initial concentration: NaN
type: Species
constant: false
is: Q9UBM1
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10400

metaM c4dc x
name: succinyl carnitine
is: HMDB02013
has only substance units: false
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
is: C02862
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM hexdicoa r
is: C08260
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00672

metaM ksi pre27 g
is: HMDB00175
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial concentration: 1.0
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 27
is: C00130
is: SBO:0000247

metaR r0716
type: Reaction
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR URATEt
reversible: false
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is described by: ECO:0000000

metaR EICOSTETCPT2
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
name: carnitine transferase
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

metaM ipdp c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
initial concentration: 1.0
is: HMDB01347
constant: false
type: Species
is: CHEBI:128769
has only substance units: false
boundary condition: false
is: C00129
name: Isopentenyl diphosphate

http://identifiers.org/biomodels.db/MODEL1310110043#_00de8420_fd8b_4ca1_a456_fc0dcbcfe49a
initial amount: NaN
is encoded by: hsa:8854
is: O94788
initial concentration: NaN
name: ALDH1A2
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaM icit c
type: Species
is: HMDB00193
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16087
initial concentration: 1.0
name: Isocitrate
is: C00311
constant: false
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

http://identifiers.org/biomodels.db/MODEL1310110043#_b1e6a480_1de6_45f5_97df_de39f60e13d0
is encoded by: hsa:2629
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: GBA
initial amount: NaN
is: P04062

metaR CORE4GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
product: MODEL1310110043#

metaR P4502C19
fast: false
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.48
notes: GENE_ASSOCIATION: (1557.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:3442670 NOTES:omeprazole 5 methyl hydroxylation assumed to take place on outer membrane - since a xenobiotic NJ
modifier: MODEL1310110043#
name: cytochrome P450 2C19
is: SBO:0000176

metaR r2109
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
product: MODEL1310110043#
modifier: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110043#_9a78af36_e226_4318_acff_10d30cf66879
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6817
name: SULT1A1
initial concentration: NaN
boundary condition: true
type: Species

metaM ksi pre11 g
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 11

metaR UMPK2n
reversible: true
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (CTP),nuclear
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR NDPK8n
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
product: MODEL1310110043#

metaM HC02208 c
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27696
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1

http://identifiers.org/biomodels.db/MODEL1310110043#_353423af_d7c1_4f9b_aa6a_b9dba2127d54
initial concentration: NaN
name: _642502_1_c
is: SBO:0000252
is encoded by: hsa:642502
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_ac6e03e0_9318_41ba_b623_5424365c4423
type: Species
is encoded by: hsa:1545
initial concentration: NaN
is: SBO:0000252
name: CYP1B1
initial amount: NaN
has only substance units: false
is: Q16678
boundary condition: true
constant: false

metaR r2108
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110043#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM mi14p c
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_0ef6529b_e83e_4cf5_a250_e482c3e50a76
is: P19961
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:280
type: Species
constant: false
has only substance units: false
name: AMY2B
boundary condition: true

metaR SUCCtp
reversible: true
name: succinate transporter, peroxisome
type: Reaction
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
product: MODEL1310110043#

metaR r2526
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: true

metaM gpi sig r
is: SBO:0000247
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: CHEBI:58190
type: Species
notes: FORMULA: Y CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00224
has only substance units: false
initial amount: NaN

metaM msa m
has only substance units: false
constant: false
is: CHEBI:33190
name: 3-oxopropanoate
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB11111

http://identifiers.org/biomodels.db/MODEL1310110043#_bfe510bb_b81b_4f70_9c3b_413b1034e88d
constant: false
name: GMPR2
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51292
is: Q9P2T1
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_78a05db9_1941_47d4_911e_0164923e430a
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PDE9A
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5152

metaR r0308
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
product: MODEL1310110043#
modifier: MODEL1310110043#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_c1de3a6b_5f93_4dbe_8c92_6c60a78733bd
initial amount: NaN
initial concentration: NaN
is: P49748
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:37
has only substance units: false
name: ACADVL

metaR FACOAL80i
kinetic law: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
modifier: MODEL1310110043#
type: Reaction
name: fatty-acid--CoA ligase (octanoate)
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_23aadf66_d1db_4b0f_b20a_c746984d42cd
boundary condition: true
type: Species
has part: B4DY56
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:498
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN

metaR r2107
fast: false
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR COAtg
reversible: true
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: CoA transport in Golgi via diffusion
fast: false
is: SBO:0000185
type: Reaction

metaM dnad c
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: Deamino-NAD+
initial amount: NaN
is: CHEBI:18304
is: HMDB01179
boundary condition: false
constant: false
is: C00857

metaR r1911
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_8b23f6d1_60d0_4c5e_b814_0640b2925f01
is: P28331
initial amount: NaN
has only substance units: false
name: NDUFS1
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4719

http://identifiers.org/biomodels.db/MODEL1310110043#_ba843e8c_33f1_4b72_b6aa_c34b57569b96
constant: false
is: SBO:0000252
is encoded by: hsa:2645
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GCK
is: Q53Y25

metaR LAPCOAl
name: lysosomal acid phosphorylase (CoA)
fast: false
product: MODEL1310110043#
reversible: false
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110043#
reactant: MODEL1310110043#

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaM gdpfuc g
is: CHEBI:57984
is: HMDB01095
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
name: GDP-L-fucose(2-)

metaM 3mb2coa m
boundary condition: false
is: SBO:0000247
name: 3-methylbut-2-enoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: CHEBI:57344
has only substance units: false
constant: false
is: HMDB01493

metaR r0021
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
is: SBO:0000176
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
reactant: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_87db8e79_eb97_4e9b_acbc_007e37735440
name: PISD
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: Q9UG56
is: SBO:0000252
is encoded by: hsa:23761

http://identifiers.org/biomodels.db/MODEL1310110043#_17b3cb74_4058_4404_9bf4_0d8162e8fccb
is encoded by: hsa:4831
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: NME2
is: P22392
type: Species
boundary condition: true
initial concentration: NaN

metaR H2O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
name: hydrogen peroxide peroxisomal transport via diffusion
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
reversible: true

metaR r2106
fast: false
product: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR r0309
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
modifier: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_10ceb527_3149_48c5_90b3_ea5d80a74228
constant: false
is: SBO:0000252
name: SI
type: Species
initial concentration: NaN
is encoded by: hsa:6476
initial amount: NaN
boundary condition: true
has only substance units: false
is: P14410

http://identifiers.org/biomodels.db/MODEL1310110043#_1e65420f_0dc9_4f43_aaa4_69c435d56897
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8034
initial amount: NaN
is: P16260
boundary condition: true
is: SBO:0000252
name: SLC25A16

metaR PPItr
kinetic law: MODEL1310110043#
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
reversible: true
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR NACHEXA20ly
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
name: beta-N-acetylhexosaminidase A, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110043#_dd464565_a20f_4ab4_bca6_787aa1341b6e
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AV727634
name: _AV727634_1_c
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_990a7a06_2fdb_4409_8a13_bcfd90207e43
name: HMOX2
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: P30519
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3163
constant: false

metaM 3tetd7ecoa c
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-coa
type: Species
initial concentration: 1.0
is: HMDB05066
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_fc7a0099_da21_4b5c_b0a9_13a3311b1462
type: Species
constant: false
initial amount: NaN
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM carn c
initial concentration: 1.0
is: HMDB00033
initial amount: NaN
name: carnosine
type: Species
constant: false
is: CHEBI:15727
boundary condition: false
has only substance units: false
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
is: SBO:0000247

metaM eicostet c
initial concentration: 1.0
initial amount: NaN
name: eicosatetranoic acid
is: HMDB02177
is: CHEBI:36033
constant: false
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
boundary condition: false
is: SBO:0000247
type: Species

metaR r0022
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110043#
product: MODEL1310110043#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110043#
is: SBO:0000176

metaR FAOXC101x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_41c17a14_b72f_4272_9b21_10e2efdf2345
is encoded by: hsa:23464
name: GCAT
type: Species
is: E2QC23
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_9696ac7b_6664_465b_8c15_d0176f7703f2
is encoded by: hsa:4706
name: NDUFAB1
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: O14561
is: SBO:0000252
type: Species
initial concentration: NaN

metaM dsmsterol r
is: CHEBI:17737
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
name: desmosterol
is: HMDB02719
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
boundary condition: false
is: SBO:0000247

metaR HOCTDACBP
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3a48ea5a_20cd_40b2_8314_ffce9a663d16
initial amount: NaN
is: Q9BWD1
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:39
constant: false
is: SBO:0000252
has only substance units: false
name: ACAT2

metaR TYRTA
reversible: true
kinetic law: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
product: MODEL1310110043#
name: tyrosine transaminase
modifier: MODEL1310110043#
is: SBO:0000176
fast: false

metaR RETNt
reversible: true
fast: false
is: SBO:0000185
name: retinoic acid transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is described by: ECO:0000000

metaM dcsptn1coa m
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
type: Species
constant: false
has only substance units: false
is: C16173
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
is: HMDB06513
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110043#_07639075_e91c_4a6b_b0b5_23a9a6865fd0
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:5336
is: SBO:0000252
initial amount: NaN
is: P16885
boundary condition: true
name: PLCG2

metaM prostge2 e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
has only substance units: false
is: HMDB01220
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:606564
constant: false

metaR OAGD3te
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110043#
name: oagd3 hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false

metaM dlnlcgcoa m
type: Species
has only substance units: false
is: CHEBI:27979
constant: false
initial amount: NaN
initial concentration: 1.0
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaM dutp n
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
constant: false
type: Species
is: CHEBI:17625
boundary condition: false
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110043#_7161cdb3_f147_405d_bce1_83550a6242a6
initial concentration: NaN
name: PC
initial amount: NaN
boundary condition: true
is: P11498
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5091
type: Species

metaM CE5120 m
type: Species
initial amount: NaN
constant: false
name: trans-2-cis-8-tetradecadienoyl-CoA
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
boundary condition: false
is: CHEBI:57923
initial concentration: 1.0

metaM h2o l
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
constant: false
has only substance units: false
name: water
type: Species
initial amount: NaN
is: HMDB02111
is: SBO:0000247

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR ABO4g
reversible: false
product: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false

metaR XYLTD Dr
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
fast: false
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: xylitol dehydrogenase (D-xyulose-forming)
reactant: MODEL1310110043#
reversible: true
is: SBO:0000176

metaR r2343
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110043#

metaR RE3347C
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: RE3347
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000

metaM L2aadp m
is: CHEBI:58672
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: L-2-aminoadipate(1-)
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
constant: false

metaM k e
is: C00238
initial amount: NaN
constant: false
is: CHEBI:29103
is: HMDB00586
type: Species
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM 3thexddcoa c
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoylcoa
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB02014
type: Species

metaM 2dp6mobq m
initial amount: NaN
is: CHEBI:50773
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
boundary condition: false
has only substance units: false

metaM thm c
initial concentration: 1.0
constant: false
is: HMDB00235
is: C00378
type: Species
is: SBO:0000247
notes: FORMULA: C12H17N4OS CHARGE: 1
boundary condition: false
initial amount: NaN
is: CHEBI:0
has only substance units: false
name: Thiamin

metaM dutp m
is: HMDB01191
is: SBO:0000247
initial amount: NaN
is: CHEBI:17625
boundary condition: false
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

http://identifiers.org/biomodels.db/MODEL1310110043#_52026c46_3b56_443e_b4d6_8a7b0e99c30a
name: NANS
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:54187
initial concentration: NaN
is: Q9NR45
boundary condition: true
is: SBO:0000252

metaM doco13ac e
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: docosenoic acid (C22:1)
constant: false
notes: FORMULA: C22H41O2 CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB02068

metaR DHEAtr
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Dehydroepiandrosterone transport
is described by: ECO:0000269
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_003f9099_0770_4795_a00e_eea228af6f52
constant: false
has only substance units: false
is: Q16795
name: NDUFA9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4704

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM atp x
is: CHEBI:57299
name: ATP(4-)
is: SBO:0000247
is: HMDB00538
constant: false
has only substance units: false
initial concentration: 1.0
is: C00002
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d7eaec40_7651_47a4_9cf0_7b9d80b2471a
constant: false
has only substance units: false
is: P15121
is: SBO:0000252
is encoded by: hsa:231
type: Species
name: AKR1B1
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_75c01d31_8099_46a9_a579_478adcca4054
constant: false
type: Species
is encoded by: hsa:374291
is: SBO:0000252
is: O75251
name: NDUFS7
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR FAOXC121C10x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_ec0090d2_6788_4cb0_ad01_da1ee68674c3
is encoded by: hsa:3141
name: HLCS
is: SBO:0000252
type: Species
is: P50747
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaM prostge2 c
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
has only substance units: false
boundary condition: false
type: Species
is: HMDB01220
initial amount: NaN
is: CHEBI:606564

metaR GGH 10FTHF5GLUe
product: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_48fce2fd_5ebe_453e_9b02_4d4b74cc176f
initial concentration: NaN
is encoded by: hsa:278
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: AMY1C
is: P04745
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_f9f4d5dd_b418_401e_a904_8a039b35a5fa
is: SBO:0000252
is encoded by: hsa:AA532636
type: Species
name: _AA532636_1_m
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR ASCBt4
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
modifier: MODEL1310110043#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110043#
name: L-ascorbate transport via proton symport

metaR OAGD3tg
type: Reaction
reversible: true
name: oagd3 hs intracellular transport
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110043#

metaM retinol cis 11 c
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
is: CHEBI:16302
name: 11-cis-retinol
initial amount: NaN
is: SBO:0000247

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM k c
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
is: CHEBI:29103
is: SBO:0000247
is: C00238
name: potassium
constant: false
is: HMDB00586

metaR HSPGtly
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: heparan sulfate transport, extracellular to lysosome
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110043#

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaR r2341
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110043#
reversible: true

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR RE1342C
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
name: RE1342
reversible: true

metaM slfcys c
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00731
initial amount: NaN
notes: FORMULA: C3H8NO5S2 CHARGE: -1
name: S-Sulfo-L-cysteine
constant: false
is: C05824
is: SBO:0000247

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM tmndnccrn c
type: Species
has only substance units: false
is: CHEBI:16987
initial amount: NaN
name: Timnodonyl carnitine
is: SBO:0000247
boundary condition: false
is: HMDB12130
constant: false
initial concentration: 1.0
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1

metaR FAOXC2252053m
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid

metaR HEXDICOAACBPx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_9aefa9d9_911a_4e52_854e_03e378bdced3
type: Species
is: SBO:0000252
name: GLDC
is encoded by: hsa:2731
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P23378
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_bb6b6096_7035_4d5e_9bf5_70930972bc35
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: P27338
name: MAOB
is encoded by: hsa:4129

http://identifiers.org/biomodels.db/MODEL1310110043#_f0469ca1_82f6_4d05_ba15_bf83bdb7d164
initial amount: NaN
is: SBO:0000252
type: Species
name: UCK1
initial concentration: NaN
is encoded by: hsa:83549
has only substance units: false
is: Q5JT09
constant: false
boundary condition: true

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reversible: true
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR HCO3 CLt
is: SBO:0000185
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
fast: false
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000269
reactant: MODEL1310110043#
reversible: true
name: bicarbonate transport (Cl-/HCO3- exchange)
modifier: MODEL1310110043#

metaR OCTDECCACT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_45dbf9c2_cabf_4a41_8656_e9729775faf6
is: B7Z6S1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2629
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: GBA

metaM na1 r
type: Species
constant: false
is: HMDB00588
is: SBO:0000247
boundary condition: false
name: sodium(1+)
is: CHEBI:29101
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
initial amount: NaN

metaR GLYt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
name: glycine reversible transport via proton symport
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_049273a1_9097_4e4d_854e_7c5cfae25c71
name: BAAT
is: Q14032
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:570

http://identifiers.org/biomodels.db/MODEL1310110043#_22b748d7_85b5_4404_a1f8_10c61286e213
type: Species
is: B3KUV7
name: PIGA
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5277
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_37633ff3_1372_4eed_8d32_fab51a949edf
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O75038
name: PLCH2
is encoded by: hsa:9651
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_fda97e3e_fa11_46bf_80d2_7b0cffb6e154
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:84105
initial amount: NaN
has only substance units: false
is: Q9H0N5
constant: false
name: PCBD2

metaM od2coa c
is: C16218
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:50570
type: Species
is: HMDB06529
name: trans-Octadec-2-enoyl-CoA
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_58ec579b_f854_4905_b8c7_de28e5752c62
name: ATP5I
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:521
is: P56385
is: SBO:0000252
constant: false

metaR r2346
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_6189b2d2_adfd_4657_a074_eb0884e1f7c7
type: Species
name: CHST2
is: Q9Y4C5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9435
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR DDCRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM retinol cis 11 e
has only substance units: false
constant: false
is: CHEBI:16302
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinol
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_53c31245_6318_4aca_a1a2_79f5cc87a45b
type: Species
initial amount: NaN
name: ALDH3B1
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: P43353
is encoded by: hsa:221
is: SBO:0000252

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
modifier: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
fast: false
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)

metaM slfcys e
boundary condition: false
notes: FORMULA: C3H8NO5S2 CHARGE: -1
type: Species
initial amount: NaN
is: C05824
initial concentration: 1.0
is: SBO:0000247
is: HMDB00731
has only substance units: false
name: S-Sulfo-L-cysteine
constant: false

metaR r2347
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110043#
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_630d04c6_87b6_4880_8870_af07f7ad971d
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: PANK1
initial amount: NaN
constant: false
is encoded by: hsa:53354
is: SBO:0000252

metaR ARSA
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.8
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: Arylsulfatase A
modifier: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
type: Reaction
reversible: false
kinetic law: MODEL1310110043#

metaR r2344
kinetic law: MODEL1310110043#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110043#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_c428975f_707c_4041_bd5d_90ae52c368e3
boundary condition: true
initial amount: NaN
name: ALDOB
is: SBO:0000252
is encoded by: hsa:229
is: P05062
type: Species
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_b839802c_e1e0_4adb_ac68_75d20351253b
name: BCKDHA
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: B4DP47
is encoded by: hsa:593
is: SBO:0000252
constant: false
type: Species

metaM akg c
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00026
is: HMDB00208
type: Species
constant: false
is: CHEBI:16810
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
name: 2-Oxoglutarate

metaM h2o m
is: CHEBI:15377
has only substance units: false
initial concentration: 1.0
name: H2O
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02111
type: Species
initial amount: NaN
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaM CE1940 e
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB01423
name: spermidine monoaldehyde 2
boundary condition: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
is: CHEBI:57287
constant: false
is: C00010
initial concentration: 1.0

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR CLFORtex
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
name: chloride transport via formate countertransport
fast: false
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM sucr e
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: Sucrose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: SBO:0000247
is: CHEBI:17992
constant: false
is: C00089
is: HMDB00258

metaR EX c4dc
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaM xoltetrol m
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: CHEBI:17278
is: HMDB01231
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR IDOAASE2ly
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
is: SBO:0000176
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: alpha-L-iduronidase, lysosomal

metaM 3dodtricoa x
initial amount: NaN
name: 3,6,9-dodecatrienoylcoa
boundary condition: false
constant: false
is: C05279
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110043#_22c4598a_23bf_4a47_9c3d_933db63caae3
constant: false
initial concentration: NaN
is: P49189
is: SBO:0000252
is encoded by: hsa:223
boundary condition: true
type: Species
has only substance units: false
name: ALDH9A1
initial amount: NaN

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
fast: false
name: beta-galactosidase, lysosomal

metaM nadp x
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: SBO:0000247
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
initial amount: NaN
constant: false
is: HMDB00217
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM h2o n
is: SBO:0000247
constant: false
is: CHEBI:15377
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
name: water
has only substance units: false
is: HMDB02111

metaM 2octdectecoa m
is: SBO:0000247
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN

metaR G14T20g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
reversible: false
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR EX c5dc
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR AG13T14g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR FAOXC142C122x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM ksi deg7 l
name: keratan sulfate I, degradation product 7
has only substance units: false
initial amount: NaN
is: CHEBI:16953
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: HMDB00812

metaM nm2masn g
type: Species
initial amount: NaN
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
notes: FORMULA: C42H70N3O30X CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: C05884

metaR GAL3ST11
is: SBO:0000176
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.11
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
type: Reaction
reactant: MODEL1310110043#
reversible: false
product: MODEL1310110043#
name: Galactosylceramide sulfotransferase

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

metaR r1020
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
name: Postulated transport reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9066ef80_ba09_4397_bc7b_82dfa927399e
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:112
type: Species
name: ADCY6
constant: false

metaR ACCOAtn
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
name: acetyl-CoA transport, nuclear
fast: false
type: Reaction

metaR CYSGLYexR
reversible: true
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000185
modifier: MODEL1310110043#
type: Reaction
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
product: MODEL1310110043#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_7f1c3c21_59a9_4d4b_989b_7ea43e032ffe
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC9A2
is: Q9UBY0
constant: false
boundary condition: true
is encoded by: hsa:6549
initial amount: NaN

metaR DNDPt9m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: dADP transport via dTDP antiport
type: Reaction
fast: false

metaR r2136
modifier: MODEL1310110043#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110043#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_c22cef8a_15e1_4420_887e_9a201ac7f2a1
is: P33121
initial amount: NaN
name: ACSL1
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2180
initial concentration: NaN

metaM 56dura c
is: SBO:0000247
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: HMDB00076
initial amount: NaN
is: CHEBI:15901
constant: false

metaM cholcoa x
initial concentration: 1.0
is: HMDB01374
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
name: choloyl-CoA(4-)
boundary condition: false
type: Species
is: CHEBI:57373

http://identifiers.org/biomodels.db/MODEL1310110043#_9f5eceae_6c80_4440_ba3a_de3094a55127
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:R06874
name: _R06874_1_r
has only substance units: false
initial concentration: NaN

metaR COt
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: CO transporter via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
product: MODEL1310110043#
is: SBO:0000185
reversible: true

metaR PYDXDH
kinetic law: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.3.1
name: pyridoxal dehydrogenase
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
product: MODEL1310110043#
is described by: ECO:0000269
modifier: MODEL1310110043#
fast: false

metaM atp r
type: Species
constant: false
is: C00002
is: CHEBI:57299
name: ATP(4-)
boundary condition: false
is: SBO:0000247
is: HMDB00538
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r1418
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaM amuco c
constant: false
is: SBO:0000247
name: 2-aminomuconate(2-)
is: HMDB01241
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57937
notes: FORMULA: C6H6NO4 CHARGE: -1 INCHI: InChI=1S/C6H7NO4/c7-4(6(10)11)2-1-3-5(8)9/h1-3H,7H2,(H,8,9)(H,10,11)/p-2/b3-1+,4-2- HEPATONET_1.0_ABBREVIATION: HC00907
initial concentration: 1.0

metaM glac c
has only substance units: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: HMDB06355
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:18268
initial concentration: 1.0
boundary condition: false
name: D-glucurono-6,3-lactone
constant: false

metaR CSEPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is: SBO:0000176
fast: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
reversible: false

metaR CHATn
modifier: MODEL1310110043#
is described by: ECO:0000269
reversible: true
name: Choline O-acetyltransferase
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaR r2137
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110043#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110043#
is: SBO:0000185
modifier: MODEL1310110043#

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a3206f43_c475_431e_b420_2be6d92ef64c
is: Q9NRA2
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:26503
constant: false
initial concentration: NaN
name: SLC17A5

http://identifiers.org/biomodels.db/MODEL1310110043#_e0e17332_a10f_4a5a_9c9d_cd1265de7b34
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:5152
boundary condition: true
name: PDE9A
initial concentration: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM na1 x
name: sodium(1+)
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB00588
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial amount: NaN
boundary condition: false
is: CHEBI:29101
has only substance units: false

metaR CITRtm
is described by: ECO:0000269
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: citrulline mitochondrial transport via proton antiport
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_9a7aa539_2ff8_459f_bdb9_fc4e3f5bd1c7
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: P43353
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ALDH3B1
is encoded by: hsa:221

metaM dcamp c
is: HMDB00536
type: Species
has only substance units: false
is: CHEBI:57567
is: SBO:0000247
name: N6-(1,2-Dicarboxyethyl)-AMP
initial concentration: 1.0
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794
initial amount: NaN
boundary condition: false

metaR r0813
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
reversible: false
is: SBO:0000185
reactant: MODEL1310110043#

metaM clpndcoa c
initial concentration: 1.0
has only substance units: false
type: Species
is: C16166
boundary condition: false
is: HMDB06267
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: SBO:0000247
name: clupanodonyl CoA
is: http://identifiers.org/pubchem.compound/47205476
constant: false

metaR MI1PS
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
name: myo-Inositol-1-phosphate synthase
is: SBO:0000176
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.5.1.4

metaR r1177
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: EC:3.1.1.13
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reversible: false
type: Reaction

metaM acrn c
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57589
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00201
name: O-acetylcarnitine

metaM thexddcoa m
name: trans7,10-hexadecadienoylcoa
has only substance units: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
boundary condition: false
is: SBO:0000247

metaR RE2814M
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000176
reversible: true
name: RE2814
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_802645bb_4e1b_459c_9756_532133253eaa
initial amount: NaN
is encoded by: hsa:4710
type: Species
constant: false
is: O95168
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: NDUFB4

metaR RE1519M
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110043#
product: MODEL1310110043#
reversible: true
fast: false
reactant: MODEL1310110043#
name: RE1519
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3dcb05c1_4327_4c50_ae6b_06b6c82f327a
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9843
type: Species
name: HEPH
constant: false
boundary condition: true
initial concentration: NaN
is: E9PHN8

metaR NTP3e
reactant: MODEL1310110043#
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-triphosphatase (GTP)
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:

metaM phytcoa x
is: CHEBI:57391
name: phytanoyl-CoA(4-)
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01359
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_473e901d_17de_400d_ac7e_5ef3ad191752
boundary condition: true
name: COX5A
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:9377
is: P20674
is: SBO:0000252
type: Species
initial concentration: NaN

metaM 4hexdtetcoa m
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
boundary condition: false
name: 4,7,10,13-hexadecatetraenoylcoa

metaM h2o r
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
is: HMDB02111
is: C00001
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_8e887fb3_4dd3_41c9_b30c_10bfc2af417a
name: _AA419122_1_c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AA419122
initial amount: NaN

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM xu5p D c
name: D-xylulose 5-phosphate(2-)
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: CHEBI:57737
is: HMDB00868
is: SBO:0000247

metaR KHK2
name: ketohexokinase (D-xylulose)
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.1.3
is: SBO:0000176
kinetic law: MODEL1310110043#
is described by: ECO:0000269

metaR r0819
modifier: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
type: Reaction
product: MODEL1310110043#
fast: false
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR CO2tm
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
fast: false
reversible: true
kinetic law: MODEL1310110043#
name: CO2 transport (diffusion), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_317ac18d_05eb_4265_a40b_1090209d72a4
type: Species
boundary condition: true
is encoded by: hsa:55753
initial amount: NaN
has only substance units: false
constant: false
name: OGDHL
is: SBO:0000252
initial concentration: NaN
is: Q9ULD0

metaM cs c l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
is: CHEBI:36005
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
is: HMDB02183
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaR DMNONCRNt
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
reversible: true
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
type: Reaction

metaR ACCOAtr
is described by: ECO:0000000
reversible: true
fast: false
name: acetyl-coa transport
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
type: Reaction
is: SBO:0000185

metaR S6TASE13ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110043#
reversible: true
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_a6f1f6ab_e1ae_470a_a868_39a78ca902b9
name: SLC23A1
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9UHI7
is encoded by: hsa:9963

metaM ksi pre34 g
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: C00130
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 34
constant: false
initial amount: NaN
is: CHEBI:58053
is: HMDB00175

metaR B3GNT11g
kinetic law: MODEL1310110043#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_94be6f3d_8832_4ac0_9abd_24d9c7b7dbca
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O60733
initial concentration: NaN
boundary condition: true
name: PLA2G6
is encoded by: hsa:8398
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_7f90569d_890d_4c15_a51f_89f5307f9cf5
initial concentration: NaN
has only substance units: false
constant: false
name: PDE9A
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5152

metaR FAOXC102x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3af005af_1b73_4486_a49b_3780f00ec1aa
constant: false
name: SLC24A3
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9HC58
has only substance units: false
initial amount: NaN
is encoded by: hsa:57419

metaM acac e
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
is: SBO:0000247
is: HMDB00060
name: acetoacetate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaM h2o x
constant: false
has only substance units: false
is: CHEBI:15377
is: C00001
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: H2O
is: HMDB02111

metaR TAURt4 2 r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110043#
modifier: MODEL1310110043#
name: taurine transport (sodium symport) (2:1)
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_febfb9e1_0547_4404_8842_617956e9f894
is encoded by: hsa:AA526438
name: _AA526438_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaM crvnc c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:36005
name: cervonic acid, C22:6 n-3
is: HMDB02183
notes: FORMULA: C22H31O2 CHARGE: -1
initial concentration: 1.0

metaR NACHEX23ly
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reversible: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction

metaM mn l
is: HMDB06535
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_e36e2e47_054b_425a_8c49_98a29e013376
is: Q9Y5P4
is encoded by: hsa:10087
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: COL4A3BP

metaR SGPL12r
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110043#
reversible: false
name: Sphingosine-1-phosphate lyase
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
type: Reaction
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_7519c86a_a6d9_4f69_872b_263414014476
is: Q59F77
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:5330
type: Species
boundary condition: true
name: PLCB2
initial amount: NaN
is: SBO:0000252

metaR S3TASE1ly
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110043#
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR DECDICRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaM ksi deg6 l
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
name: keratan sulfate I, degradation product 6
is: HMDB00143
has only substance units: false
is: CHEBI:12936

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110043#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
reactant: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110043#

metaM acac c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial concentration: 1.0
is: HMDB00060
name: acetoacetate
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_d7c5d7f9_7ad4_49e6_904a_895a29e65260
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: C5HZ13
boundary condition: true
name: CLC
is encoded by: hsa:1178
has only substance units: false

metaM dcsptn1coa c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
initial amount: NaN
has only substance units: false
is: HMDB06513
constant: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_ff0f37ed_0d47_4ce4_9268_4fcf7f4cbe22
is: Q8WXF9
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:66035
type: Species
name: SLC2A11

metaM 2dr5p c
type: Species
is: CHEBI:57651
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
constant: false
is: HMDB01031
boundary condition: false
initial concentration: 1.0
name: 2-deoxy-D-ribose 5-phosphate(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR HGNTOR
product: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.5
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaM dlnlcgcoa c
type: Species
name: dihomo-gamma-linolenyl coenzyme A
initial concentration: 1.0
is: CHEBI:27979
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaR 3HBCDm
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000254
type: Reaction
product: MODEL1310110043#
reversible: true
is: SBO:0000176
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
modifier: MODEL1310110043#

metaR RE2814R
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
reversible: true
is described by: ECO:0000000
name: RE2814
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#

metaR R group phosphotase 2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110043#
reversible: false
name: R group phosphotase 2

metaR NACHEXA1ly
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110043#
reactant: MODEL1310110043#
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110043#_7a999174_db94_4bd9_9944_fd5e0a606e3a
is: G5E960
name: PLCB3
has only substance units: false
constant: false
is encoded by: hsa:5331
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r2139
is described by: ECO:0000000
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110043#
reactant: MODEL1310110043#

metaR NTD4e
name: 5'-nucleotidase (CMP), extracellular
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_050af1d0_28be_42b7_9928_8429d06635f9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:26279
name: PLA2G2D
constant: false
initial amount: NaN
is: Q9UNK4
has only substance units: false
type: Species

metaM mi134p c
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58414
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: HMDB01143
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false
boundary condition: false

metaM crvnc e
initial concentration: 1.0
is: CHEBI:36005
type: Species
is: HMDB02183
has only substance units: false
is: SBO:0000247
constant: false
name: cervonic acid, C22:6 n-3
initial amount: NaN
notes: FORMULA: C22H31O2 CHARGE: -1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_2fa6a2ed_e6f8_4969_bd74_c6ce8b503433
name: NDUFS4
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: O43181
is encoded by: hsa:4724
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_c78af828_ca53_4743_8ae8_074859544876
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: P36969
name: GPX4
constant: false
is encoded by: hsa:2879
boundary condition: true
is: SBO:0000252

metaR PE HStm
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
type: Reaction

metaR LEUKTRF4t
is described by: ECO:0000000
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110043#
name: leukotriene F4 transport
type: Reaction
is: SBO:0000185

metaR HDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110043#
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_1ac55809_c98d_4c0d_89a7_578fc8352d92
has only substance units: false
boundary condition: true
name: AMY1B
is: P04745
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:277
initial amount: NaN
initial concentration: NaN

metaM 6a2ohxnt x
is: SBO:0000247
type: Species
is: CHEBI:17534
initial amount: NaN
initial concentration: 1.0
is: HMDB12151
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
constant: false
name: 6-amino-2-oxohexanoic acid
has only substance units: false
boundary condition: false

metaR ACOAD10m
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
fast: false
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269

metaM tettet6coa x
is: SBO:0000247
constant: false
name: tetracosatetraenoyl coenzyme A
is: C16171
initial concentration: 1.0
type: Species
is: HMDB06516
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205481
boundary condition: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1

metaR SERDGLNexR
kinetic law: MODEL1310110043#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true
is: SBO:0000185
name: D-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f5583554_0494_434e_a9a9_a12662d7f428
constant: false
has only substance units: false
is: P56181
initial concentration: NaN
is encoded by: hsa:4731
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFV3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_3fd2d26b_9cea_4eaf_b4c5_97964b666a5e
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
constant: false
boundary condition: true
has part: P07195
type: Species
has only substance units: false
name: LDHA:LDHB
is encoded by: hsa:3945

metaR r2141
reactant: MODEL1310110043#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110043#
product: MODEL1310110043#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR R group phosphotase 1
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 1

http://identifiers.org/biomodels.db/MODEL1310110043#_843aeb12_be08_41a6_b6cb_5276f0be75c5
has only substance units: false
name: SUCLG2
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: Q96I99
is: SBO:0000252
type: Species
is encoded by: hsa:8801

metaR TCYNTt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
kinetic law: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
product: MODEL1310110043#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reversible: false
is: SBO:0000185

metaR r1018
type: Reaction
product: MODEL1310110043#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: Transport reaction
is described by: ECO:0000000

metaM acrn m
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00201
is: SBO:0000247
name: O-acetylcarnitine
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
is: CHEBI:57589
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_ffc9d8eb_f1bf_4348_8ae7_d1779e44d2ec
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9P1E4
is encoded by: hsa:4122
name: MAN2A2

metaR GLCAASE5ly
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110043#
reversible: false
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a2c6c70f_d0c0_410e_9e81_b43fde2d0ce3
is: P80404
name: ABAT
has only substance units: false
constant: false
is encoded by: hsa:18
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR NACHEX19ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110043#
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
type: Reaction
reversible: false
kinetic law: MODEL1310110043#

metaR r0483
is: SBO:0000176
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110043#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

metaR r0611
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.3.1
kinetic law: MODEL1310110043#
is: SBO:0000176
reactant: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
fast: false
is described by: ECO:0000000
modifier: MODEL1310110043#

metaR FAOXC225C204x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_67b01502_4a8f_4f9d_8c07_d36a7f5a844a
type: Species
is: SBO:0000252
name: CYP2C8
is: P10632
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1558
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_e783c8ef_2310_40ab_b4a0_6be7c5c2d305
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ABCB4
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5244

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
is: HMDB00304
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: Type IIIH glycolipid
initial amount: NaN
is: CHEBI:57847
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0

metaR S6TASE4ly
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110043#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: N-acetylgalactosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110043#_ea5f3a5d_3694_4f4a_8764_bf17060c4a61
is: SBO:0000252
is encoded by: hsa:79901
initial concentration: NaN
has only substance units: false
name: CYBRD1
is: B4DWD7
boundary condition: true
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_0b328844_714d_40d2_bd41_d6882d89f859
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4725
has only substance units: false
constant: false
name: NDUFS5
initial concentration: NaN
boundary condition: true
is: Q6IBA0
type: Species

metaR GLXO1
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.2.4
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110043#
name: glyoxylate oxidase
product: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000269
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_6124f756_f07f_44fd_8eaa_16694d4fb45b
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:26
initial concentration: NaN
is: P19801
is: SBO:0000252
name: ABP1

metaR GLCNACASE2ly
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110043#
reversible: false
is described by: ECO:0000000
product: MODEL1310110043#

metaM xol7a r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:1296
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01496
name: 20-hydroxycholesterol

metaR r2140
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185
modifier: MODEL1310110043#

metaR FAOXC143C123m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaM cs a deg4 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
is: CHEBI:16953
type: Species
initial amount: NaN
is: HMDB00812

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_d5585a5f_ae9a_4a94_a9ca_9a33f1d0c825
name: TSTA3
is: Q13630
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:7264
initial concentration: NaN

metaM pail345p hs c
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
is: SBO:0000247
is: CHEBI:57836
boundary condition: false
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_60147ea8_18f0_4b3f_86fd_04157fd94f95
is: B4DY56
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:498
boundary condition: true
name: ATP5A1
initial concentration: NaN
constant: false
type: Species

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110043#
type: Reaction
fast: false
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: aspartate transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
reversible: true
product: MODEL1310110043#

metaR CAATPS
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.6.3.8
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
fast: false
is: SBO:0000185
product: MODEL1310110043#
is described by: ECO:0000269
reversible: false
name: Ca ATPase
reactant: MODEL1310110043#

metaR LNELDCCRNt
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000185
modifier: MODEL1310110043#
product: MODEL1310110043#
name: transport into the mitochondria (carnitine)
type: Reaction
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_9d685892_b29a_4315_873c_b0f654c3091e
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4695
initial concentration: NaN
is: SBO:0000252
is: O43678
type: Species
name: NDUFA2

metaR P45017A2r
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1586.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:12915666,PMID:7893148 NOTES:ER noted in locuslink ref - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. PMID_12915666 quantifies kinetic parameters using microsomal proteins from fetal testicular tissue with tritiated hydroxy-pregnenolone as substrate
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.9
product: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
type: Reaction
name: Cytochrome P450 17A1
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_76e67f9a_2cac_4623_92b0_02b9eb4e3d73
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8833
is: P49915
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: GMPS
type: Species

metaM 3octdece1crn e
notes: FORMULA: C25H47NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB13336
has only substance units: false
constant: false
boundary condition: false
name: 3-hydroxy-octadecenoyl carnitine
initial amount: NaN
is: SBO:0000247
type: Species

metaR HPACtr
name: hydroxyphenylacetate transport via diffusion
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000000
kinetic law: MODEL1310110043#
reversible: true
is: SBO:0000185
type: Reaction

metaR XOL27OHtm
is described by: ECO:0000000
is: SBO:0000185
name: 27 hydroxy cholesterol transport
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
type: Reaction
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaR TCYNTtm
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110043#
fast: false
name: Thiocyanate transport via diffusion (mitochondrial)
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000

metaR P45027A1m
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
reactant: MODEL1310110043#
name: Cytochrome P450 27
is described by: ECO:0000269
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
product: MODEL1310110043#
type: Reaction

metaM 3mop e
is: SBO:0000247
initial concentration: 1.0
is: HMDB00491
has only substance units: false
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1

http://identifiers.org/biomodels.db/MODEL1310110043#_5afb779b_fc02_4faf_9954_7a845b168f21
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDH1A2
boundary condition: true
constant: false
is encoded by: hsa:8854
initial concentration: NaN
is: F5H2Y9
type: Species

metaR 4NPHSFte
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false
reversible: true
name: xenobiotic transport
kinetic law: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_52a0b40c_a9c3_4f9d_a248_e125c46b4692
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1345
is: P09669
initial amount: NaN
name: COX6C
boundary condition: true

metaR r1755
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_2797fae4_74be_498d_ab76_712f8b9f1326
is: SBO:0000252
name: ATP1A2
is encoded by: hsa:477
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P50993
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_397d6460_b7ef_45c1_b7e0_c2f87a334ae5
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3000
name: GUCY2D
boundary condition: true
initial amount: NaN
is: Q02846

http://identifiers.org/biomodels.db/MODEL1310110043#_778a515e_3fec_41af_bee5_05a9beabbc10
type: Species
is encoded by: hsa:2110
initial amount: NaN
is: Q16134
initial concentration: NaN
name: ETFDH
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR PI45P5P
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
kinetic law: MODEL1310110043#
reversible: false
modifier: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000

metaR SPHMYLNtg
fast: false
reactant: MODEL1310110043#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: sphingomyelin intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_a2dae86d_2fab_4530_a6a0_3c72a7c17dde
is encoded by: hsa:314
type: Species
has only substance units: false
initial amount: NaN
is: O75106
boundary condition: true
constant: false
name: AOC2
initial concentration: NaN
is: SBO:0000252

metaR DUDPtn
is: SBO:0000185
name: dUDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: true
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000

metaM dolglcp U c
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
constant: false

metaR 41R2A1H12BOOX
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaR r1019
type: Reaction
reversible: true
product: MODEL1310110043#
name: Postulated transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaM ksii core4 pre3 g
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00130
name: keratan sulfate II biosynthesis, precursor 3
constant: false
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C55H89N5O38X CHARGE: -1
type: Species
is: HMDB00175

metaR NTD8
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110043#
name: 5'-nucleotidase (dGMP)
reactant: MODEL1310110043#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR 4NPHSULT
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110043#
name: 4-Nitrophenol Sulfotransferase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaR r1754
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
name: Y+LAT2 Utilized transport

metaR r0614
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
reactant: MODEL1310110043#
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
fast: false

metaR r0377
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110043#
fast: false

metaR H2Ot
fast: false
modifier: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
product: MODEL1310110043#
is described by: ECO:0000269
name: H2O transport via diffusion
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
reversible: true

metaR GMPtg
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185
kinetic law: MODEL1310110043#
reversible: true
fast: false
name: GMP transport (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is described by: ECO:0000269

metaM 4mop c
is: HMDB00695
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:17865
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR DSAT
reversible: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: dihydrosphingosine N-acyltransferase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_57f49ff0_3215_4fac_8254_6d2928480f09
is encoded by: hsa:1607
name: DGKB
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r0615
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110043#
fast: false
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.168

metaM etfox m
type: Species
is: SBO:0000247
is: HMDB00145
has only substance units: false
name: Electron transfer flavoprotein oxidized
boundary condition: false
is: CHEBI:17263
constant: false
notes: FORMULA: R CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaM ksii core2 pre2 g
name: keratan sulfate II biosynthesis, precursor 2
is: HMDB00175
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58053
is: C00130

metaR r1167
reactant: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
name: EC:2.3.1.26
is: SBO:0000176
fast: false

metaM ptrc m
is: CHEBI:326268
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01414
name: 1,4-butanediammonium
type: Species
notes: FORMULA: C4H14N2 CHARGE: 2 INCHI: InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2/p+2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM acac m
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00060
name: acetoacetate
type: Species

metaR r0480
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
reversible: true

metaM glygn4 e
initial amount: NaN
notes: FORMULA: C18H31O16X CHARGE: 0
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
boundary condition: false
is: SBO:0000247
is: CHEBI:4167
constant: false
type: Species
initial concentration: 1.0
is: HMDB00122
has only substance units: false

metaM man6p c
initial amount: NaN
is: SBO:0000247
is: CHEBI:17369
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01078
name: D-Mannose 6-phosphate
constant: false
type: Species

metaR RE1807C
reversible: true
reactant: MODEL1310110043#
product: MODEL1310110043#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is: SBO:0000176
type: Reaction
name: RE1807
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM sarcs c
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0
is: HMDB00271
has only substance units: false
is: C00213
is: CHEBI:3513
initial concentration: 1.0
type: Species
initial amount: NaN
name: Sarcosine
constant: false
is: SBO:0000247

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM ksi pre19 g
is: CHEBI:58053
constant: false
is: SBO:0000247
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 19
is: C00130
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
type: Species

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110043#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110043#
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000176

metaR LINKDEG1ly
fast: false
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaM 3otdcoa m
name: 3-Oxotetradecanoyl-CoA
is: CHEBI:28726
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB03935
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261

metaR EX caro LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Carotene exchange
type: Reaction

metaR FAOXC161C161OHm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaM Ssq23epx r
has only substance units: false
is: HMDB01188
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15441
name: (S)-2,3-epoxysqualene
initial concentration: 1.0
constant: false

metaR S6TASE21ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58593
name: dCDP(3-)
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_91231040_da17_4076_a918_ddf313a3a91c
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q53FV7
is: SBO:0000252
name: CPT1B
type: Species
has only substance units: false
is encoded by: hsa:1375
constant: false

metaM fgam c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: C04376
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01308
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
has only substance units: false
type: Species
is: CHEBI:58426

metaM phyt c
initial amount: NaN
constant: false
is: CHEBI:37257
is: HMDB00801
has only substance units: false
name: phytanate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial concentration: 1.0
type: Species

metaR r0617
is: SBO:0000176
fast: false
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_e1cbe95a_3d14_4fd5_98bc_cecefbac6dba
is encoded by: hsa:1559
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P11712
name: CYP2C9

metaR MI1PP
name: myo-inositol 1-phosphatase
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
kinetic law: MODEL1310110043#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_3dd31058_fe41_4043_9215_dfcb9eb9531b
has only substance units: false
constant: false
is encoded by: hsa:522
initial amount: NaN
initial concentration: NaN
is: Q6NZ59
is: SBO:0000252
name: ATP5J
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_07c59e1f_6a63_40ad_a465_95c6992eb094
boundary condition: true
initial amount: NaN
is encoded by: hsa:9334
initial concentration: NaN
constant: false
is: SBO:0000252
name: B4GALT5
type: Species
has only substance units: false
is: O43286

metaR r0822
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM acngalgbside hs g
type: Species
is: CHEBI:16523
initial concentration: 1.0
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
name: sialyl galactosylgloboside
boundary condition: false
is: HMDB03406
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_1c58dbd2_b58f_414b_ae2e_e991294db195
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: DGUOK
is: SBO:0000252
initial concentration: NaN
type: Species
is: E5KSL5
is encoded by: hsa:1716

metaM na1 c
initial amount: NaN
name: Sodium
is: HMDB00588
boundary condition: false
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1
is: C01330
has only substance units: false
is: CHEBI:4541
initial concentration: 1.0
constant: false
type: Species

metaR MACACI
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: false
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is: SBO:0000176
name: maleylacetoacetate isomerase
reactant: MODEL1310110043#
type: Reaction

metaR r1168
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110043#
is described by: ECO:0000000
name: EC:2.3.1.26
reactant: MODEL1310110043#
product: MODEL1310110043#
reversible: false
is: SBO:0000176

metaM dcdp n
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58593
name: dCDP(3-)
is: SBO:0000247
type: Species
is: HMDB01245
constant: false
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaM dutp c
is: HMDB01191
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00460
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
boundary condition: false
is: CHEBI:17625

metaM sarcs e
is: SBO:0000247
is: CHEBI:15611
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
initial amount: NaN
name: sarcosine
has only substance units: false
initial concentration: 1.0
is: HMDB00271
type: Species
constant: false

metaM adrnl c
name: Adrenaline
is: HMDB00068
has only substance units: false
is: CHEBI:33568
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788

metaR r2142
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110043#
reversible: true
modifier: MODEL1310110043#

metaR r0618
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110043#
reversible: true
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110043#_62bbdaed_24f4_4ad7_9eb5_287b7891d149
initial concentration: NaN
type: Species
constant: false
name: _AI631997_1_m
is encoded by: hsa:AI631997
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR HPYRRy
modifier: MODEL1310110043#
fast: false
name: Hydroxypyruvate reductase (NADPH)
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.79
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269

metaR RE1135C
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110043#
reversible: true
modifier: MODEL1310110043#
fast: false
name: RE1135
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
product: MODEL1310110043#

metaM 2maacoa m
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57335
name: 2-methylacetoacetyl-CoA(4-)
is: HMDB01157
initial amount: NaN

metaR FUT911g
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reactant: MODEL1310110043#
is: SBO:0000176
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.152
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
reversible: false
is described by: ECO:0000269
type: Reaction
name: Alpha-(1,3)-fucosyltransferase

metaR r1758
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
type: Reaction

metaR r0821
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110043#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#

metaR FAOXC102m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR r1010
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: Postulated transport reaction
reversible: true
reactant: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction

metaM tetdec2crn c
notes: FORMULA: C21H37NO4 CHARGE: 0
boundary condition: false
has only substance units: false
type: Species
name: tetradecadienoyl carnitine
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB02014
is: SBO:0000247

metaM 3mldz c
is: HMDB04181
type: Species
is: CHEBI:28104
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 1-methylimidazole-4-acetaldehyde
is: SBO:0000247
constant: false
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827

http://identifiers.org/biomodels.db/MODEL1310110043#_a3ea032a_8fbe_4128_b9c6_b96801b2a1c0
boundary condition: true
is encoded by: hsa:AI926493
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: _AI926493_1_c
initial concentration: NaN

metaM CE4722 e
is: C01936
notes: FORMULA: C38H49N6O10 CHARGE: -1 INCHI: InChI=1/C38H50N6O10/c1-22(2)32(35(50)40-27(16-17-31(46)47)37(52)44-19-7-11-30(44)38(53)54)42-33(48)28(21-23-8-4-3-5-9-23)41-34(49)29-10-6-18-43(29)36(51)26(39)20-24-12-14-25(45)15-13-24/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,49)(H,42,48)(H,46,47)(H,53,54)/p-1/t26-,27+,28+,29-,30+,32-/m1/s1 EHMN_ABBREVIATION: CE4722
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: beta-casomorphin (1-6)
type: Species
is: http://identifiers.org/pubchem.compound/5041

http://identifiers.org/biomodels.db/MODEL1310110043#_f7ddff4f_dcc0_4d64_8582_dec20ea321cb
is encoded by: hsa:33
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: P28330
name: ACADL
initial concentration: NaN
boundary condition: true

metaR HIStN1
is: SBO:0000185
product: MODEL1310110043#
name: Histidine transport (Na, H coupled)
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_f509ad34_7c7e_4105_889e_360e454cfb9d
has part: Q6I9V2
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:498
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
has part: P25705
is: SBO:0000297
is encoded by: hsa:509
constant: false
boundary condition: true

metaM glu5p m
boundary condition: false
initial amount: NaN
name: L-Glutamate 5-phosphate
is: SBO:0000247
is: CHEBI:58274
has only substance units: false
type: Species
constant: false
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
initial concentration: 1.0
is: HMDB01228

metaM xol27oh r
is: CHEBI:17703
type: Species
constant: false
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial amount: NaN
boundary condition: false
name: 26-hydroxycholesterol
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_40f916db_868a_4195_8ce0_0779a26c1bf1
name: PNPO
is encoded by: hsa:55163
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: Q9NVS9

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
name: I-antigen
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:26174

http://identifiers.org/biomodels.db/MODEL1310110043#_f6ee78c8_2652_49c9_b304_68f7fe2e638e
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: P52789
is encoded by: hsa:3099
type: Species
boundary condition: true
is: SBO:0000252
name: HK2

metaR RE1532M
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR NACHEX12ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
product: MODEL1310110043#
reactant: MODEL1310110043#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110043#

metaM xoltetrol c
is: CHEBI:17278
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
has only substance units: false
type: Species
is: HMDB01231
initial amount: NaN

metaR FAOXC4C4DCc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaR HPETFABP1tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 5-HPETE into the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_1f529146_d3c6_40fe_a029_73d5f365e584
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: MYO5B
initial concentration: NaN
is: Q9H6Y6
constant: false
has only substance units: false
is encoded by: hsa:4645

metaR AMCOXO
fast: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
name: 2-aminomuconate reductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:not sure about name NCD
reversible: false

metaM L2aadp c
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58672
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
boundary condition: false
name: L-2-aminoadipate(1-)
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_343ac5af_fbb4_419d_9f86_ff800ff67535
type: Species
is: SBO:0000252
constant: false
is: E7EPT3
initial concentration: NaN
name: ALDH7A1
has only substance units: false
boundary condition: true
is encoded by: hsa:501
initial amount: NaN

metaM xtsn c
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
has only substance units: false
is: CHEBI:18107
constant: false
type: Species
is: HMDB00299
name: xanthosine
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM lnlc e
is: HMDB00673
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30245
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate

metaR PRISTANALtx
type: Reaction
reactant: MODEL1310110043#
product: MODEL1310110043#
name: pristanal peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reversible: true
fast: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185

metaR FAOXC163Gm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_3cef827b_2e5f_42ac_b012_2a2375128f9d
initial amount: NaN
is encoded by: hsa:6392
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SDHD
constant: false
initial concentration: NaN
is: O14521
type: Species

metaR LEULEULAPc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaM dgchol e
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00637
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR r2035
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
is: SBO:0000185

metaM Rtotal2coa c
initial amount: NaN
name: R total 2 coenzyme A
constant: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: HMDB00294
has only substance units: false
is: CHEBI:16199
type: Species
boundary condition: false
is: C00086
initial concentration: 1.0
is: SBO:0000247

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM na1 e
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00588
is: C01330
name: Sodium
is: CHEBI:4541
notes: FORMULA: Na CHARGE: 1
is: SBO:0000247
has only substance units: false

metaM 3mop m
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: HMDB00491
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
boundary condition: false
has only substance units: false

metaR r1012
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
name: Postulated transport reaction
kinetic law: MODEL1310110043#
fast: false
type: Reaction
is: SBO:0000185

metaR GLYCTDle
is described by: ECO:0000134
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110043#
fast: false
name: difussion of glycerol accross the brush border membrane
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110043#

metaM ptrc c
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01414
constant: false
is: SBO:0000247
is: CHEBI:326268
name: Putrescine
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaR FAOXC143C123x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaM mi1p D c
is: CHEBI:58433
type: Species
constant: false
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: SBO:0000247

metaM hexdectecoa m
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

metaM 2dodtricoa m
name: 2,6,9-dodecatrienoylcoa
initial concentration: 1.0
is: C05279
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB11123
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false

metaM oaa c
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
is: HMDB00223
initial amount: NaN
is: CHEBI:3338
name: Oxaloacetate
is: C00036
is: SBO:0000247

metaM dcsptn1coa x
has only substance units: false
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR RE1807M
fast: false
type: Reaction
product: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE1807
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#

metaM lnlc c
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00673
initial amount: NaN
is: CHEBI:30245
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
type: Species

metaR ALATHRNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110043#
is: SBO:0000185
fast: false
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
reversible: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110043#
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

metaR NACHEXA22ly
fast: false
reversible: false
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
modifier: MODEL1310110043#
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaR CYTK12n
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP),nuclear
kinetic law: MODEL1310110043#
reversible: true

metaR r1011
is: SBO:0000185
reversible: false
name: Transport reaction
type: Reaction
product: MODEL1310110043#
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_cee1493d_34af_452c_8f0b_dc8df671a66b
is: SBO:0000252
is encoded by: hsa:6487
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: Q5T4Y1
name: ST3GAL3

metaM 3dodtricoa m
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: C05279
is: HMDB11123
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
name: 3,6,9-dodecatrienoylcoa

metaM ksi deg38 l
is: HMDB00143
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: CHEBI:12936
boundary condition: false
name: keratan sulfate I, degradation product 38
initial concentration: 1.0

metaM acrn r
is: HMDB00201
name: O-acetylcarnitine
is: SBO:0000247
constant: false
is: CHEBI:57589
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
type: Species

metaM dgchol c
name: glycochenodeoxycholate
type: Species
constant: false
is: SBO:0000247
is: HMDB00637
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
has only substance units: false
is: CHEBI:36252
initial amount: NaN
boundary condition: false

metaM pheme e
is: HMDB03178
is: CHEBI:17627
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Protoheme
constant: false
has only substance units: false
is: C00032
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN
type: Species

metaM 3hmp m
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00023
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: SBO:0000247
is: CHEBI:11805

http://identifiers.org/biomodels.db/MODEL1310110043#_fa25dfb1_a21a_4f85_a02d_1ee24a0417be
is encoded by: hsa:2747
boundary condition: true
constant: false
is: P49448
type: Species
name: GLUD2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM cs b l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02183
initial concentration: 1.0
is: CHEBI:36005
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d6946f05_3cb0_4355_a427_841fc11486bd
constant: false
name: _AI620219_1_e
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI620219
boundary condition: true
initial amount: NaN

metaM ptrc e
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: CHEBI:326268
constant: false
boundary condition: false
initial concentration: 1.0
name: Putrescine
has only substance units: false
is: HMDB01414
is: SBO:0000247
is: C00134
type: Species

metaR 4HPROLTASCT1
reversible: false
name: exit of hydroxy-prloine across the basolateral surface of enterocytes
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 17475673. NOTES:ASCT1 helps in absorption of hydroxy-proline by aiding in its exit from the enterocytes into the blood stream. The ASCT1 transport system operates as an obligatory amino acid exchanger, Na+ depedant manner. Alaine is the preeferred susbstrate.
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000134

metaR r0502
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
modifier: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true

metaR CITL
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reactant: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
name: Citrate lyase
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR FOAXC122C101x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR PGISr
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.4
reactant: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
kinetic law: MODEL1310110043#
reversible: true
name: Prostaglandin I2 synthase
fast: false

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
is: HMDB01252
boundary condition: false
is: CHEBI:15710
initial concentration: 1.0
type: Species
name: betaine aldehyde
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_d8b30712_f1dc_491a_a3a5_e24041abc14e
has only substance units: false
constant: false
name: SLC26A1
is encoded by: hsa:10861
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR FACOAL2042
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
name: fatty-acid--CoA ligase
is described by: ECO:0000000

metaR r1014
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
type: Reaction
product: MODEL1310110043#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_91cf7ab7_67e1_49d4_94fa_11fab941d0f6
boundary condition: true
name: B3GALT5
initial concentration: NaN
is encoded by: hsa:10317
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_471ad8f3_a4c4_4dbe_844b_2cbda7bb1c52
has only substance units: false
name: UAP1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6675
is: Q16222
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_88723155_1d8b_4a92_aea6_9b5159666080
has only substance units: false
constant: false
name: ST20
initial concentration: NaN
is: SBO:0000252
is: Q9HBF5
initial amount: NaN
is encoded by: hsa:400410
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_35404cad_8723_41a5_be41_93f2d99d0824
has only substance units: false
type: Species
is: SBO:0000252
is: Q9H999
initial concentration: NaN
is encoded by: hsa:79646
initial amount: NaN
constant: false
name: PANK3
boundary condition: true

metaM CE1943 e
is: C00010
constant: false
is: HMDB01423
initial amount: NaN
name: spermidine dialdehyde
is: CHEBI:57287
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
type: Species
boundary condition: false
is: SBO:0000247

metaM xol27oh m
is: HMDB02103
initial amount: NaN
type: Species
name: 26-hydroxycholesterol
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247
is: CHEBI:17703

metaM dcdp c
type: Species
is: HMDB01245
is: C00705
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: CHEBI:58593
initial amount: NaN
boundary condition: false
name: dCDP

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR r1013
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110043#
name: Transport reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
product: MODEL1310110043#
fast: false
is described by: ECO:0000000

metaR r0488
reversible: true
is: SBO:0000176
product: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
is described by: ECO:0000000
reactant: MODEL1310110043#
type: Reaction

metaR FOLt2le
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110043#
fast: false
product: MODEL1310110043#
is described by: ECO:0000134
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
name: folate transport via anion exchange

metaM cholcoa c
type: Species
initial concentration: 1.0
name: choloyl-CoA(4-)
is: CHEBI:57373
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01374
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_120713fb_21ba_4f9a_a48c_88683d4ddd16
initial concentration: NaN
is: Q9BRB3
is: SBO:0000252
name: PIGQ
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:9091
constant: false
boundary condition: true

metaR FAOXC142C122m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_1f6efd59_3899_4261_9fef_d6e5ffbb4d7f
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AI697028
has only substance units: false
name: _AI697028_1_e
type: Species
is: SBO:0000252
boundary condition: true

metaM pheme c
boundary condition: false
is: HMDB03178
type: Species
is: SBO:0000247
is: CHEBI:17627
has only substance units: false
name: Protoheme
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
initial concentration: 1.0
is: C00032
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_d023dcac_8eed_4194_a848_47adbb0a6292
constant: false
is encoded by: hsa:5337
type: Species
name: PLD1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q59EA4
initial concentration: NaN
has only substance units: false

metaM acrn x
is: CHEBI:57589
name: O-acetylcarnitine
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

metaM tetdec2crn e
constant: false
initial amount: NaN
name: tetradecadienoyl carnitine
is: HMDB05066
is: SBO:0000247
type: Species
notes: FORMULA: C21H37NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM pdx5p c
constant: false
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
has only substance units: false
is: HMDB01319
initial concentration: 1.0
boundary condition: false
is: CHEBI:58589
name: Pyridoxine 5'-phosphate
is: C00627
type: Species
is: SBO:0000247
initial amount: NaN

metaR TDCRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR AKR1C41
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110043#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000176

metaM hdcoa c
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB06532
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Hexadecenoyl-CoA (n-C16:1CoA)

metaR HISD
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
product: MODEL1310110043#
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.3.1.3
is described by: ECO:0000269
name: histidase

metaM CE4794 m
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial amount: NaN
is: CHEBI:57923
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: cis-6-dodecenoyl-CoA
has only substance units: false

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR NDPK7n
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

metaR r0504
fast: false
is: SBO:0000176
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.3.3.10
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000000
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
modifier: MODEL1310110043#
type: Reaction
reversible: true

metaR MTHFD2
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
fast: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NAD)

metaM mgacpail hs r
constant: false
is: CHEBI:7896
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00220
is: C00249
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_f15c6b4a_e7d2_469e_807f_274789b157bf
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:594
initial amount: NaN
constant: false
is: Q9BQL0
type: Species
initial concentration: NaN
name: BCKDHB

metaR H2Oter
reactant: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
name: H2O endoplasmic reticulum transport
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_9287f84b_2b55_4164_930a_4b3ffdcd988a
is: SBO:0000252
constant: false
name: HMGCS2
type: Species
is: P54868
is encoded by: hsa:3158
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR DMHPTCRNt
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110043#
name: 2,6 dimethylheptanoyl crn transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110043#

metaR r2030
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR DPHMBDCm
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
is described by: ECO:0000000
kinetic law: MODEL1310110043#
fast: false
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
reversible: false
type: Reaction
product: MODEL1310110043#
reactant: MODEL1310110043#

metaR FORtr
reversible: true
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
fast: false
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110043#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110043#

metaM 3octdece1crn c
is: SBO:0000247
is: HMDB13336
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0
name: 3-hydroxy-octadecenoyl carnitine
type: Species
boundary condition: false
initial concentration: 1.0

metaR FAOXC225C204m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM dcacoa x
is: CHEBI:61430
has only substance units: false
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
constant: false
initial concentration: 1.0
is: C05274
boundary condition: false
is: SBO:0000247

metaR r0610
is: SBO:0000176
reactant: MODEL1310110043#
reversible: true
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#

metaM sarcs m
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: C00213
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: HMDB00271
boundary condition: false
constant: false
name: Sarcosine
is: CHEBI:15611

http://identifiers.org/biomodels.db/MODEL1310110043#_aa5f48f6_fad2_4332_9fbf_43051074d55d
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q6FHI7
constant: false
name: CA4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:762

metaM 4hexdtetcoa x
boundary condition: false
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false

metaM ksii core2 deg7 l
notes: FORMULA: C44H73N4O30X CHARGE: 0
is: CHEBI:16953
initial amount: NaN
constant: false
name: keratan sulfate II (core 2-linked), degradation product 7
type: Species
has only substance units: false
boundary condition: false
is: HMDB00812
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_d9693f2a_40d4_4142_a1ed_fd454b67a5ec
type: Species
is: O95470
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8879
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: SGPL1

metaR PSSA1 hs
is: SBO:0000176
reactant: MODEL1310110043#
name: Phosphatidylserine synthase homo sapiens
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.29
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is described by: ECO:0000269
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_f48ec7e4_ef8b_494f_a089_6e2f26f9731d
initial amount: NaN
is encoded by: hsa:7371
name: UCK2
type: Species
is: Q9BZX2
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r2352
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110043#
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110043#
fast: false

metaM lnlncacoa c
is: CHEBI:51985
type: Species
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
constant: false
name: alpha-Linolenoyl-CoA
is: SBO:0000247
is: HMDB06290
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_be9bcc74_7401_4652_81c2_1537eec1fa37
constant: false
boundary condition: true
is encoded by: hsa:4535
is: Q85KV6
initial amount: NaN
has only substance units: false
name: ND1
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r1318
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Transport reaction
product: MODEL1310110043#

metaM 5adtststerones e
is: SBO:0000247
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR r0809
fast: false
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
modifier: MODEL1310110043#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110043#
type: Reaction
product: MODEL1310110043#

metaM btamp m
initial amount: NaN
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
boundary condition: false
name: Biotinyl-5'-AMP
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:3110
is: SBO:0000247

metaM dcacoa c
boundary condition: false
is: CHEBI:61430
is: C05274
type: Species
is: HMDB06404
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0

metaM 5dpmev c
type: Species
is: HMDB01090
name: (R)-5-Diphosphomevalonate
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
initial concentration: 1.0
is: SBO:0000247

metaM dmhptcrn m
initial concentration: 1.0
is: SBO:0000247
name: 2,6 dimethylheptanoyl carnitine
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06320

metaM 4hpro LT c
has only substance units: false
is: HMDB00725
boundary condition: false
initial concentration: 1.0
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
type: Species
name: trans-4-hydroxy-L-proline
is: SBO:0000247
constant: false

metaR RE3346C
fast: false
reversible: true
modifier: MODEL1310110043#
product: MODEL1310110043#
name: RE3346
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaR S6TASE12ly
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110043#
reversible: true
is: SBO:0000176
modifier: MODEL1310110043#

metaR r2353
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR ABO5g
is described by: ECO:0000269
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
type: Reaction
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reversible: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#

metaM 7dhchsterol r
is: CHEBI:17759
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
is: HMDB00032

metaR r2018
fast: false
product: MODEL1310110043#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_c5f937e0_e372_47d4_9e4f_aaf4610390de
initial concentration: NaN
boundary condition: true
name: GGT7
constant: false
initial amount: NaN
is: A0PJJ9
is encoded by: hsa:2686
is: SBO:0000252
type: Species
has only substance units: false

metaR C81CRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM 5mta e
is: HMDB01173
boundary condition: false
constant: false
is: C00170
name: 5-Methylthioadenosine
initial concentration: 1.0
is: CHEBI:17509
has only substance units: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species

metaR FUMAC
reversible: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.7.1.2
is: SBO:0000176
kinetic law: MODEL1310110043#
name: fumarylacetoacetase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
modifier: MODEL1310110043#
type: Reaction
product: MODEL1310110043#

metaR AICART
reversible: true
kinetic law: MODEL1310110043#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
modifier: MODEL1310110043#
fast: false
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.1.2.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110043#

metaR FAOXC241C221x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_0e2dbf92_6bec_425a_bbda_02606428dbfe
type: Species
constant: false
is: SBO:0000297
is encoded by: hsa:2982
initial amount: NaN
is encoded by: hsa:2974
has only substance units: false
has part: D6RDW3
initial concentration: NaN
name: GUCY1B2:GUCY1A3
boundary condition: true

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR r2354
is described by: ECO:0000000
reversible: true
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
is: SBO:0000185

metaM memgacpail hs r
is: HMDB00054
initial amount: NaN
is: CHEBI:57977
has only substance units: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false

metaR RETH
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
reversible: false
kinetic law: MODEL1310110043#
type: Reaction
modifier: MODEL1310110043#
name: retinyl ester hydrolase
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#

metaM HC01410 m
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
name: (2E)-Hexenoyl-CoA
has only substance units: false
is: CHEBI:28706
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110043#_a2afccae_b41b_4313_8a2b_663566fc82a0
name: HK1
initial amount: NaN
is encoded by: hsa:3098
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: Q59FD4
initial concentration: NaN
boundary condition: true

metaR CSPG Btly
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
reversible: false
fast: false
name: chondroitin sulfate B transport, extracellular to lysosome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110043#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_26a3ff0a_8e0b_4b19_bcfd_bb4d2d04296b
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ST3GAL3
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:6487

metaR r2019
fast: false
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110043#
modifier: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110043#_c122fef2_7ef8_4f74_802f_5ebe780e6b1e
constant: false
name: PRDX3
is: P30048
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10935

http://identifiers.org/biomodels.db/MODEL1310110043#_a74fb92e_fac5_431e_98f8_e551b0cbcb7b
type: Species
is encoded by: hsa:8706
boundary condition: true
is: SBO:0000252
constant: false
name: B3GALNT1
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q8TDY1

metaM gln L e
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
constant: false
is: CHEBI:18050
is: HMDB00641
initial amount: NaN
boundary condition: false
type: Species
name: L-glutamine
has only substance units: false

metaR GAO1g
is described by: ECO:0000269
product: MODEL1310110043#
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
name: Ganglioside O-acetylation
reactant: MODEL1310110043#

metaR TETDECE1CRNe
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR LEUKTRE4t
is: SBO:0000185
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport
fast: false
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is described by: ECO:0000000
type: Reaction

metaM datp c
is: SBO:0000247
is: CHEBI:61404
constant: false
initial amount: NaN
name: dATP
boundary condition: false
is: C00131
type: Species
initial concentration: 1.0
is: HMDB01532
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false

metaR r2355
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110043#
type: Reaction
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000

metaM 4hpro LT e
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
name: trans-4-hydroxy-L-proline
is: HMDB00725

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR EX glyleu LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Glycylleucine exchange
type: Reaction

metaR FAOXC102C101x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaM sebcoa x
is: SBO:0000247
name: sebacoylcoa
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_017063c7_2d05_4be1_a321_2214aa56e257
name: DHFR
initial amount: NaN
is encoded by: hsa:1719
constant: false
has only substance units: false
is: SBO:0000252
is: P00374
boundary condition: true
initial concentration: NaN
type: Species

metaM apoC Lys btn m
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial amount: NaN
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
is: SBO:0000247
is: C05552
is: HMDB03134

metaR G14T2g
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110043#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110043#
is: SBO:0000176
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000

metaR CGLYt3 2
reactant: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reversible: false
type: Reaction
name: Cys-Gly transport in via proton symport
kinetic law: MODEL1310110043#
product: MODEL1310110043#
fast: false
is described by: ECO:0000304
is: SBO:0000185

metaR G14T21g
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110043#
modifier: MODEL1310110043#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110043#_e2b4973a_e294_4137_8756_ad53efe45106
initial concentration: NaN
type: Species
is: Q16790
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:768
name: CA9
constant: false
boundary condition: true
has only substance units: false

metaM ksii core2 pre10 g
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110043#_ec8dc186_7fa6_468d_b205_0962020f5ecc
boundary condition: true
constant: false
is encoded by: hsa:10400
name: PEMT
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM dolglcp U r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
boundary condition: false
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
is: CHEBI:15812
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_dbb73ee8_1a48_4410_a155_04d37f6ef72c
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AA081045
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AA081045_1_c

metaR r2013
is: SBO:0000185
type: Reaction
reversible: false
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_3b24a8a3_7d3e_440a_8f34_591204578dc0
is: SBO:0000252
name: PMM1
initial concentration: NaN
is encoded by: hsa:5372
is: A8K003
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR G14Tg
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000269
kinetic law: MODEL1310110043#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
reactant: MODEL1310110043#
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110043#

metaR C4CRNCPT2
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaR RE3524R
name: RE3524
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is: SBO:0000176

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR SUCCOAPET
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM c12dccoa c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: dodecanedioylcoa
initial amount: NaN
is: HMDB00623
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
has only substance units: false

metaR r2356
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
reversible: true
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_22c34f19_5a2e_4c8f_aee9_2d79929898f4
boundary condition: true
initial amount: NaN
name: _2544_1_c
type: Species
is encoded by: hsa:2544
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR FOLR2
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000254
fast: false
is: SBO:0000176
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
type: Reaction
name: folate reductase
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_be85792e_86cd_47db_8eb6_cc412f263883
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q8IX04
type: Species
initial concentration: NaN
name: UEVLD
is encoded by: hsa:55293
constant: false
boundary condition: true

metaR C10OHc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM ala B e
type: Species
boundary condition: false
constant: false
is: CHEBI:16958
name: beta-alanine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
is: HMDB00056

http://identifiers.org/biomodels.db/MODEL1310110043#_ee058a1b_e394_47a7_999f_13b5de06308b
is: P33897
is: SBO:0000252
is encoded by: hsa:215
has only substance units: false
boundary condition: true
constant: false
name: ABCD1
initial concentration: NaN
type: Species
initial amount: NaN

metaR r2014
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
type: Reaction
modifier: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_ab24f87f_3fcb_41fa_aac4_fa56cb076ff7
is encoded by: hsa:410
initial concentration: NaN
constant: false
boundary condition: true
name: ARSA
type: Species
is: SBO:0000252
is: P15289
initial amount: NaN
has only substance units: false

metaM clpndcoa x
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205476
constant: false
is: C16166
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
boundary condition: false
type: Species
is: HMDB06267
initial concentration: 1.0
name: clupanodonyl CoA

metaR ACOAD1fm
reactant: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
fast: false
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110043#_15c89684_ea22_47c1_9d0b_e59ecd5ab9f8
name: GALNT1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2589
is: Q10472
type: Species
initial concentration: NaN
boundary condition: true

metaR 3HCO3 NAt
kinetic law: MODEL1310110043#
is described by: ECO:0000134
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
is: SBO:0000185
type: Reaction
fast: false
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).

metaM xol7ah c
type: Species
initial concentration: 1.0
has only substance units: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: HMDB06892
initial amount: NaN
is: CHEBI:2290
constant: false
boundary condition: false

metaM phytcoa c
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
name: phytanoyl-CoA(4-)
has only substance units: false
is: HMDB01359
initial amount: NaN
constant: false
is: CHEBI:57391

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110043#
fast: false
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185

metaR RE0453C
name: RE0453
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110043#
is: SBO:0000176

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaR CYSTGLUex
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is: SBO:0000185
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false
name: L-cystine/L-glutamate exchanger
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110043#
reactant: MODEL1310110043#

metaR GALtly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reversible: false
name: galactose efflux from lysosome
is: SBO:0000185
reactant: MODEL1310110043#
is described by: ECO:0000000

metaM amet c
is: C00019
type: Species
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
is: HMDB01185
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: S-Adenosyl-L-methionine
initial concentration: 1.0

metaR MAN6PI
name: mannose-6-phosphate isomerase
kinetic law: MODEL1310110043#
reversible: true
product: MODEL1310110043#
is described by: ECO:0000304
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.8

metaR LIMNENte
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, xenobiotic transport (original and metabolized) NJ
fast: false
is described by: ECO:0000000
reactant: MODEL1310110043#
is: SBO:0000185
product: MODEL1310110043#
name: xenobiotic transport
reversible: true

metaR EX 4mtolbutamide LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4 hydroxy tolbutamide exchange
type: Reaction

metaR r2358
is described by: ECO:0000000
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110043#

metaM 2mop c
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
initial amount: NaN
is: HMDB01172
constant: false
initial concentration: 1.0
is: CHEBI:57700

http://identifiers.org/biomodels.db/MODEL1310110043#_b5f5bac5_e8fe_454a_a4eb_fe96c12064eb
has only substance units: false
is encoded by: hsa:384
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ARG2
constant: false
boundary condition: true
type: Species
is: P78540

http://identifiers.org/biomodels.db/MODEL1310110043#_f688b42c_511e_489d_895d_1bdec7170a0c
constant: false
is: C9JC79
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SCP2
has only substance units: false
is encoded by: hsa:6342
type: Species

metaM 5adtststerones c
initial concentration: 1.0
has only substance units: false
is: HMDB06278
type: Species
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
constant: false
initial amount: NaN
boundary condition: false

metaR GLNS
type: Reaction
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.1.1.15
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000254
kinetic law: MODEL1310110043#
name: glutamine synthetase
product: MODEL1310110043#
reversible: false

metaR C4x
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR ABUTD
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reactant: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
reversible: false
type: Reaction
name: Aminobutyraldehyde dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110043#_f9b9af26_5cb2_45ab_b196_a2ceb2203579
constant: false
has only substance units: false
is encoded by: hsa:79837
boundary condition: true
initial concentration: NaN
name: PIP4K2C
is: SBO:0000252
type: Species
is: B3KQV3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_ad1267aa_b6fb_4488_9b6f_72a6fd595b6e
initial amount: NaN
boundary condition: true
name: PANK2
is: SBO:0000252
is encoded by: hsa:80025
has only substance units: false
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_7c6599de_e88f_41ae_90d7_99cd9587e38c
name: B3GALT5
constant: false
is encoded by: hsa:10317
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_f1624a24_fb15_46c3_9897_931c87768692
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:9197
is: O00400
name: SLC33A1
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR LINKDEG2ly
reversible: false
reactant: MODEL1310110043#
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110043#

metaR RE1518M
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110043#
fast: false
name: RE1518
is: SBO:0000176
modifier: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110043#

metaR r1030
product: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
name: Transport reaction
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_87fc3220_40c6_4b4c_97d2_4c0e9b7bd1fd
name: ATP5E
type: Species
initial amount: NaN
is: P56381
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:514
boundary condition: true

metaM 5mta c
initial amount: NaN
type: Species
initial concentration: 1.0
name: 5-Methylthioadenosine
is: C00170
constant: false
is: HMDB01173
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
has only substance units: false
is: CHEBI:17509
is: SBO:0000247
boundary condition: false

metaR r2359
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000

metaM adrncoa m
boundary condition: false
type: Species
initial concentration: 1.0
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
name: adrenyl coenzyme A
constant: false
has only substance units: false
is: SBO:0000247

metaM 12ppd R c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: SBO:0000247
name: (R)-propane-1,2-diol
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01881
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28972

metaR AG13T15g
is: SBO:0000176
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is described by: ECO:0000000
modifier: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

metaR CSBPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110043#

metaR r2016
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_f4f70c27_a16f_42cb_9b5e_6d6ce305abd7
type: Species
is: P04183
boundary condition: true
is encoded by: hsa:7083
is: SBO:0000252
name: TK1
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0801
type: Reaction
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
product: MODEL1310110043#
is: SBO:0000185
reactant: MODEL1310110043#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110043#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM akg x
name: 2-oxoglutarate(2-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: HMDB00208
initial amount: NaN
constant: false
has only substance units: false

metaM bilglcur c
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:57767
initial concentration: 1.0
has only substance units: false

metaM xol7ah2al m
constant: false
is: HMDB06894
is: CHEBI:27428
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445

metaR ALDD21
reactant: MODEL1310110043#
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
type: Reaction
name: aldehyde dehydrogenase (pristanal, NAD)
is described by: ECO:0000304
kinetic law: MODEL1310110043#
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM ura e
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: uracil
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17568
is: HMDB00300
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110043#_a909b3a9_a431_4ee0_9f49_537da82c6dfd
is encoded by: hsa:10948
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: STARD3
has only substance units: false
is: B4DUY1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_1b751899_0492_49ee_8f71_f6a5ecebe341
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:7389
is: P06132
has only substance units: false
name: UROD
initial concentration: NaN
constant: false

metaR r2122
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000000
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110043#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110043#_8a295dd8_744f_4851_b48e_16de70d3bc3c
name: SLC7A10
boundary condition: true
constant: false
is: SBO:0000252
is: Q9NS82
is encoded by: hsa:56301
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM CE5121 m
constant: false
name: trans-3-decenoyl-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: CHEBI:57449

metaM dtdp c
has only substance units: false
type: Species
name: dTDP
constant: false
is: SBO:0000247
is: C00363
is: CHEBI:58369
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: HMDB01274
initial amount: NaN

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_03d776e1_881a_40bf_8bd8_ac35d3c1d362
constant: false
name: ACAA2
type: Species
is: P42765
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10449

metaR NTD1
is: SBO:0000176
kinetic law: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dUMP)
product: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.5

metaM amet r
is: HMDB01185
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
name: S-adenosyl-L-methionine
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:15414
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_25369dac_3f65_4ef6_b785_1ea489094fac
initial concentration: NaN
is encoded by: hsa:480
initial amount: NaN
has only substance units: false
has part: Q13733
type: Species
name: ATP1A4:ATP1B1
constant: false
boundary condition: true
is: SBO:0000297

metaM prostge1 c
is: HMDB01442
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57397
constant: false
is: SBO:0000247

metaR EX CE2916 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin exchange
type: Reaction

metaM ura c
boundary condition: false
initial concentration: 1.0
type: Species
is: C00106
is: SBO:0000247
initial amount: NaN
is: CHEBI:17568
is: HMDB00300
has only substance units: false
constant: false
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106

metaR FAOXC2242046m
reactant: MODEL1310110043#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
name: Beta oxidation of long chain fatty acid
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110043#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110043#_f170cb54_91d7_48a2_9b22_ae0b030448f1
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: HK1
is: P78542
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false

metaM dmhptcrn e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: 2,6 dimethylheptanoyl carnitine
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
boundary condition: false
initial amount: NaN
type: Species

metaR FAOXC181C161m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR SPC HSt
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#

metaR C120CPT1
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR SEBACACT
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM adrncoa x
has only substance units: false
is: C16170
constant: false
is: SBO:0000247
initial amount: NaN
name: adrenyl coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110043#_f8c7fd44_cb6e_4da5_95bb_37048aab1b64
is encoded by: hsa:51227
name: PIGP
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaM xoltriol c
type: Species
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
initial amount: NaN
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16496

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
initial amount: NaN
is: CHEBI:61430
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_80861b3e_6d16_4d2d_a3e7_2f9488102297
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4830
boundary condition: true
initial concentration: NaN
name: NME1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_03d59b08_eb18_473a_b2a3_6377522fbb7e
is: P00326
name: ADH1C
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:126
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_2903b490_3be3_4a85_a890_8b96e816bce4
constant: false
initial concentration: NaN
is: P19404
is: SBO:0000252
name: NDUFV2
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4729
initial amount: NaN

metaR r2123
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110043#_8b6b84fd_f6f7_45c9_80a2_c0c2339f58af
initial amount: NaN
type: Species
is encoded by: hsa:64087
name: MCCC2
has only substance units: false
initial concentration: NaN
is: Q9HCC0
boundary condition: true
is: SBO:0000252
constant: false

metaM 3oddcoa m
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: HMDB03937
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: CHEBI:27868
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_74dcbeae_7aaa_4723_a355_7e0dd03d5cf5
is: SBO:0000252
is encoded by: hsa:159
initial amount: NaN
has only substance units: false
type: Species
name: ADSS
constant: false
initial concentration: NaN
boundary condition: true
is: P30520

metaM CE1935 e
initial concentration: 1.0
is: CHEBI:57287
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
type: Species
is: C00010
has only substance units: false
boundary condition: false
constant: false
is: HMDB01423
name: spermine monoaldehyde
initial amount: NaN
is: SBO:0000247

metaM phyt e
is: CHEBI:37257
is: HMDB00801
is: SBO:0000247
name: phytanate
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
has only substance units: false
initial concentration: 1.0
type: Species

metaM ksi deg8 l
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 8
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB00143

metaR Asn X Ser Thrtr
type: Reaction
name: Asn-X-Ser/Thr transport (from ER to lysosome)
kinetic law: MODEL1310110043#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
product: MODEL1310110043#
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110043#

metaR r1429
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: Free diffusion
fast: false

metaM bilglcur e
has only substance units: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57767
initial concentration: 1.0

metaR GTHRDt
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110043#
product: MODEL1310110043#
name: Glutathione transport into mitochondria
is: SBO:0000185
type: Reaction

metaM lpam m
boundary condition: false
is: SBO:0000247
is: CHEBI:17460
is: HMDB00962
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
constant: false
name: lipoamide
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_24922c07_5c46_4188_8233_c135952f753a
is encoded by: hsa:57786
initial concentration: NaN
is: Q9NYW8
name: RBAK
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r2124
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110043#
reactant: MODEL1310110043#
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110043#_81d2ca2d_369a_4ae7_816b_5eddab1dbd99
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: G0W2N5
has only substance units: false
is encoded by: hsa:6563
name: SLC14A1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_bca7680a_9849_4fb7_9274_7e4a5a04bff4
initial amount: NaN
name: GLUD1
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: E9KL48
is encoded by: hsa:2746

metaR FAOXC122C101m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR NTD3
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dCMP)
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_e898e459_84ca_4efa_9a80_79b94ae6d347
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4725
type: Species
is: SBO:0000252
name: NDUFS5
is: Q6IBA0
initial amount: NaN

metaM dmhptcrn c
initial concentration: 1.0
name: 2,6 dimethylheptanoyl carnitine
initial amount: NaN
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB06320

metaR r2125
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#
modifier: MODEL1310110043#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110043#_0235dc33_ffa0_4af0_9a18_12bc9122fba4
is: SBO:0000252
has only substance units: false
is: Q9BW60
name: ELOVL1
initial concentration: NaN
type: Species
is encoded by: hsa:64834
initial amount: NaN
constant: false
boundary condition: true

metaM thmpp c
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
has only substance units: false
name: Thiamine diphosphate
initial amount: NaN
is: HMDB01372
is: C00068
is: CHEBI:45931
type: Species

metaR EHGLAT2m
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110043#
reversible: false
kinetic law: MODEL1310110043#
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#

metaM o2 c
constant: false
initial concentration: 1.0
is: CHEBI:15379
has only substance units: false
boundary condition: false
is: HMDB01377
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
name: O2
initial amount: NaN
type: Species

metaM ksi deg31 l
is: CHEBI:16953
is: SBO:0000247
initial amount: NaN
is: HMDB00812
has only substance units: false
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 31
type: Species
boundary condition: false

metaM dtdp e
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01274
constant: false
initial concentration: 1.0
is: CHEBI:58369

metaM prostge1 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
name: prostaglandin E1(1-)
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57397
boundary condition: false
is: HMDB01442

metaR FAOXTC101TC102m
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaR RE3273C
is: SBO:0000176
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
reactant: MODEL1310110043#
fast: false
name: RE3273
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110043#
reversible: true

metaR SFGTH
name: S-Formylglutathione hydralase
product: MODEL1310110043#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
kinetic law: MODEL1310110043#
reversible: true
type: Reaction
modifier: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.12
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:26174
is: SBO:0000247
name: nLc8Cer

http://identifiers.org/biomodels.db/MODEL1310110043#_2edc0b77_9d6b_481f_a822_28f342cfb745
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: GPD1
is: SBO:0000252
is: F8W1L5
type: Species
is encoded by: hsa:2819

http://identifiers.org/biomodels.db/MODEL1310110043#_f744ccc7_a2ed_482c_befb_33ffe9b28afc
is: SBO:0000252
name: SLC2A7
is encoded by: hsa:155184
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q6PXP3

http://identifiers.org/biomodels.db/MODEL1310110043#_b18a80f4_bc19_4561_91e6_784290c8e5a8
is encoded by: hsa:30833
initial amount: NaN
name: NT5C
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q8TCD5
type: Species
constant: false
boundary condition: true

metaR DNDPt34m
kinetic law: MODEL1310110043#
fast: false
is: SBO:0000185
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110043#
type: Reaction
name: dGDP transport via dTDP antiport
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_e9bab6a0_9b0c_49ac_9cdb_6452436f1d4c
has only substance units: false
is: SBO:0000252
constant: false
is: O00483
type: Species
is encoded by: hsa:4697
name: NDUFA4
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM ksii core2 deg9 l
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
type: Species
constant: false
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 9
has only substance units: false

metaR r2126
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#

metaM phaccoa c
has only substance units: false
name: phenylacetyl-CoA(4-)
is: CHEBI:57390
boundary condition: false
is: HMDB06503
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
initial concentration: 1.0
is: SBO:0000247

metaM amet m
is: CHEBI:15414
type: Species
is: HMDB01185
is: SBO:0000247
initial amount: NaN
name: S-Adenosyl-L-methionine
constant: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00019

metaR CHOLATEt
type: Reaction
kinetic law: MODEL1310110043#
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110043#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110043#
fast: false
product: MODEL1310110043#

metaR FAOXC183C163Gm
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR ASNCYSNaEx
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110043#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110043#
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
reactant: MODEL1310110043#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110043#_1c2568e1_0b81_44f3_843f_b65e6d6679b2
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:84735
name: CNDP1
type: Species
is: Q96KN2
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM gal1p c
has only substance units: false
is: CHEBI:58336
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00645
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate

metaM gln L c
initial amount: NaN
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
boundary condition: false
is: CHEBI:18050
has only substance units: false
name: L-glutamine
initial concentration: 1.0
constant: false
is: HMDB00641

http://identifiers.org/biomodels.db/MODEL1310110043#_d2c796e6_a1ae_4225_8161_f533320b4011
is encoded by: hsa:114
name: ADCY8
initial concentration: NaN
is: Q4F7X0
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR SPHS1Pte
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
fast: false
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110043#
product: MODEL1310110043#

metaM 2dr1p c
name: 2-Deoxy-D-ribose 1-phosphate
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
is: HMDB01351
is: CHEBI:58576
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00672
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_42259078_da01_4066_a3ef_37a2b414069c
is encoded by: hsa:10455
initial concentration: NaN
has only substance units: false
is: O75521
boundary condition: true
name: ECI2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM hs deg17 l
type: Species
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: heparan sulfate, degradation product 17
is: CHEBI:21338
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02704

metaM 2mop m
is: SBO:0000247
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
initial amount: NaN
name: 2-methyl-3-oxopropanoate
is: HMDB01172
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false

metaR UGCG
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/2.4.1.80
type: Reaction
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
kinetic law: MODEL1310110043#
name: Ceramide glucosyltransferase
reactant: MODEL1310110043#
is: SBO:0000176
product: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_45f8c139_4bfb_415b_9423_a4f62816b4a3
constant: false
is encoded by: hsa:4126
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O00462
name: MANBA

metaM dudp c
name: dUDP
initial amount: NaN
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: C01346
boundary condition: false
constant: false
type: Species
is: HMDB01000
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaM 2dodtricoa x
is: C05279
initial amount: NaN
is: SBO:0000247
name: 2,6,9-dodecatrienoylcoa
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB11123

metaR NTD5
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
name: 5'-nucleotidase (dTMP)
kinetic law: MODEL1310110043#
reversible: false
is described by: ECO:0000134
product: MODEL1310110043#
fast: false
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110043#_8b283200_4c95_4536_a960_22f987f19f40
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:18
has only substance units: false
name: ABAT
is: P80404
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR r2127
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1428
product: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
reversible: true
reactant: MODEL1310110043#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110043#
type: Reaction
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110043#_85839145_73e1_417a_8d50_a9dc3aa9022a
is: SBO:0000252
is: Q92835
constant: false
is encoded by: hsa:3635
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: INPP5D

metaM ksii core2 deg8 l
type: Species
constant: false
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110043#_bc4bf630_f08a_41b7_8700_5686cbf2f63d
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:D29675
initial amount: NaN
type: Species
constant: false
name: _D29675_1_e
initial concentration: NaN

metaM ala B m
is: HMDB00056
is: CHEBI:16958
name: beta-alanine
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaM o2 e
type: Species
constant: false
is: CHEBI:15379
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: O2
is: SBO:0000247
initial amount: NaN
is: C00007

metaM ksi deg9 l
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 9
type: Species
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110043#_33bfc9fd_8682_4c5b_ae77_d803518257d1
constant: false
has only substance units: false
has part: B4E3E9
is: SBO:0000297
is encoded by: hsa:4967
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DLD:DLST:OGDH:PDHX
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_897eed44_4079_47f5_b294_e0e1bef634b0
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: TREH
has only substance units: false
is: SBO:0000252
is encoded by: hsa:11181
constant: false
type: Species
is: O43280

metaR r2128
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110043#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000000
fast: false

metaM nadp c
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: C00006

metaR L LACt2r
modifier: MODEL1310110043#
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110043#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
product: MODEL1310110043#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110043#_6f845cdd_dc95_4ef5_90a7_6148949dc9ba
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:4522
boundary condition: true
initial amount: NaN
name: MTHFD1
is: P11586

http://identifiers.org/biomodels.db/MODEL1310110043#_fec2c3ba_1165_4ae7_94aa_e037c5844872
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
type: Species
constant: false

metaR P45027A11m
kinetic law: MODEL1310110043#
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110043#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

metaM 6dhf e
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
initial amount: NaN
constant: false
is: HMDB06563
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110043#_0e6888a8_5d4e_48d3_9bf4_f428ce76f8f5
is: SBO:0000252
is encoded by: hsa:28231
boundary condition: true
has only substance units: false
type: Species
constant: false
is: Q96BD0
initial amount: NaN
name: SLCO4A1
initial concentration: NaN

metaR RE0453N
modifier: MODEL1310110043#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: RE0453
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
fast: false

metaR ARGNm
notes: GENE_ASSOCIATION: (384.1) SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:9144563 NOTES:SAB m
modifier: MODEL1310110043#
is described by: ECO:0000269
kinetic law: MODEL1310110043#
reversible: false
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.5.3.1
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110043#
name: arginase (m)

metaR r2129
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110043#
modifier: MODEL1310110043#
reactant: MODEL1310110043#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110043#_1c2e5bec_e4d0_43da_9abf_1ae9815585b1
type: Species
name: SLC24A4
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:123041
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_ad2fb0b1_707d_40e3_b535_41c84ca5db80
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2348
initial amount: NaN
is: P15328
is: SBO:0000252
name: FOLR1
boundary condition: true
type: Species

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM 3mop c
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:28654
constant: false
initial concentration: 1.0
is: HMDB00491

http://identifiers.org/biomodels.db/MODEL1310110043#_8779c60c_c834_4397_bbec_e1e01864f2bd
boundary condition: true
is encoded by: hsa:492
is: Q16720
type: Species
name: ATP2B3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM 4hoxpacd c
is: HMDB03767
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:15621
name: (4-hydroxyphenyl)acetaldehyde
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
constant: false

metaR BTNPL
name: holocarboxylase synthestase (biotin protein ligase)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110043#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110043#

metaR GLYSNAT5tc
kinetic law: MODEL1310110043#
product: MODEL1310110043#
reactant: MODEL1310110043#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110043#
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM biocyt m
is: HMDB03134
initial concentration: 1.0
type: Species
boundary condition: false
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
is: C05552
constant: false
has only substance units: false

metaR B3GALT3g
reversible: false
fast: false
modifier: MODEL1310110043#
is: SBO:0000176
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 3
is version of: http://identifiers.org/ec-code/2.4.1.79
kinetic law: MODEL1310110043#
product: MODEL1310110043#
type: Reaction
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110043#_ec2eeda1_6630_4f7e_82ce_8553d425ee89
is: P16152
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:873
is: SBO:0000252
boundary condition: true
name: CBR1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_3471f089_61ad_4862_8885_a781ec0e4695
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: PDE9A
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5152
initial concentration: NaN

metaM 4pyrdx c
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
name: 4-pyridoxate
initial concentration: 1.0
is: HMDB00017
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:30959
is: SBO:0000247

metaR RE3421R
reactant: MODEL1310110043#
name: RE3421
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110043#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
kinetic law: MODEL1310110043#

metaM biocyt c
is: HMDB03134
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
constant: false
is: C05552
is: SBO:0000247
initial concentration: 1.0
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110043#_9cd353e6_4d56_428b_8a2a_9a6fa1361231
name: PPT2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9UMR5
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:9374
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_e4d31625_b41e_429d_9770_a5d661553774
type: Species
boundary condition: true
is: SBO:0000252
name: TXNRD3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:114112
is: Q86VQ6
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110043#_347c393a_d79a_40f4_b678_e63b64fba147
is: Q53TV9
has only substance units: false
initial amount: NaN
type: Species
name: RPE
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6120
initial concentration: NaN

metaM 3octdeccrn c
initial concentration: 1.0
name: 3-hydroxyoctadecanoyl carnitine
type: Species
constant: false
has only substance units: false
notes: FORMULA: C25H49NO5 CHARGE: 0
boundary condition: false
initial amount: NaN
is: HMDB13336
is: SBO:0000247

metaR FADH2tx
product: MODEL1310110043#
reversible: true
reactant: MODEL1310110043#
kinetic law: MODEL1310110043#
type: Reaction
name: FADH2 transporter, peroxisomal
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000

metaM thmpp m
name: Thiamine diphosphate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: HMDB01372
has only substance units: false
is: CHEBI:45931
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
reactant: MODEL1310110043#
modifier: MODEL1310110043#
reversible: true
fast: false
type: Reaction
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176
product: MODEL1310110043#
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_e2c8ea08_7dc2_426e_bdb8_b79ec2e7c2c3
constant: false
name: PIGB
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:9488
initial amount: NaN
is: Q92521
is: SBO:0000252
has only substance units: false

metaR FUM
product: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase
modifier: MODEL1310110043#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110043#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110043#_81edf33b_beb7_4b4f_b3bf_4f70f3017c2b
is: P05091
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_33b60914_5c98_4bdf_bbc5_cac49febcd30
is: F6SH78
name: ELOVL5
is encoded by: hsa:60481
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110043#_b7d6ac30_7b79_44d8_ae8f_c72058e6f8d0
name: ACAT2
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: Q9BWD1
is encoded by: hsa:39
is: SBO:0000252

metaM CE2839 e
initial concentration: 1.0
has only substance units: false
name: maltodecaose
is: C01936
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839

metaM m2mn l
boundary condition: false
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
has only substance units: false
is: HMDB06537

metaR r1423
product: MODEL1310110043#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110043#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: false
fast: false
reactant: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_fee3876d_4091_409e_8336_ecc82ad2149d
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:2348
initial amount: NaN
type: Species
is: SBO:0000252
name: FOLR1

metaM c12dccoa x
initial amount: NaN
is: HMDB03712
constant: false
boundary condition: false
name: dodecanedioylcoa
type: Species
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM fad r
is: CHEBI:16238
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
is: HMDB01248

metaR GALASE20ly
name: beta-galactosidase, lysosomal
product: MODEL1310110043#
reactant: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reversible: false
kinetic law: MODEL1310110043#
is described by: ECO:0000000
modifier: MODEL1310110043#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR PROt4
modifier: MODEL1310110043#
name: Na+/Proline-L symporter
reactant: MODEL1310110043#
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110043#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110043#

http://identifiers.org/biomodels.db/MODEL1310110043#_4f263dd3_ef12_4fb0_86f3_48ec41bab86b
name: SLC12A5
is: Q9H2X9
is encoded by: hsa:57468
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110043#_4efe0ddb_ba31_4c13_bb7a_3a3278b0c6ba
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFA7
is: Q6FG42
constant: false
is encoded by: hsa:4701
initial concentration: NaN

metaR P45017A1r
product: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.14.99.9
fast: false
reactant: MODEL1310110043#
type: Reaction
reversible: false
name: Cytochrome P450 17A1
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1586.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.99.9 Confidence Level: 4 AUTHORS: PMID:7893148 NOTES:cytosolic by default - RETURN AND CHECK AFTER DEEPER LIT SEARCH NJ. Kinetic studies conducted with recombinant e.coli transfected with human p450c17 with pregnenolone as substrate

metaM 1pyr5c m
type: Species
initial concentration: 1.0
has only substance units: false
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
is: HMDB01301
boundary condition: false
is: C03912
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
constant: false

metaR 3DPHBH2
is described by: ECO:0000000
reactant: MODEL1310110043#
product: MODEL1310110043#
is: SBO:0000176
reversible: false
fast: false
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADPH)
kinetic law: MODEL1310110043#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT

metaR r0365
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is: SBO:0000176
modifier: MODEL1310110043#
kinetic law: MODEL1310110043#
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reactant: MODEL1310110043#
is described by: ECO:0000000
product: MODEL1310110043#
type: Reaction

metaM 7dhchsterol c
has only substance units: false
is: SBO:0000247
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17759
type: Species
constant: false
is: HMDB00032

metaM tolbutamide c
initial concentration: 1.0
is: CHEBI:27999
notes: FORMULA: C12H18N2O3S CHARGE: 0 INCHI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
name: tolbutamide
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: C07148