metaR HISSNAT5tc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM mercplac c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8118
is: SBO:0000247
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: C05823
is: HMDB02127
name: 3-Mercaptolactate

metaR CDPDAGtm
product: MODEL1310110041#
fast: false
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#

metaM 3dsphgn c
initial amount: NaN
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01480
is: CHEBI:58299
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_23fca165_93fd_4c12_9b77_6f32c4878100
initial concentration: NaN
type: Species
is: SBO:0000252
name: TKTL2
has only substance units: false
boundary condition: true
is: Q9H0I9
constant: false
initial amount: NaN
is encoded by: hsa:84076

http://identifiers.org/biomodels.db/MODEL1310110041#_ee80ca08_14bd_4bf1_8e9c_811a6380783e
name: VNN3:VNN2:VNN1
initial amount: NaN
has part: O95497
boundary condition: true
constant: false
type: Species
is encoded by: hsa:8876
is encoded by: hsa:55350
is: SBO:0000297
is encoded by: hsa:8875
has part: A8K7W0
has only substance units: false
initial concentration: NaN

metaR 25HVITD3tm
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
name: 25-hydroxyvitamin D3 transport from mitochondria
kinetic law: MODEL1310110041#

metaM thcrm hs g
constant: false
boundary condition: false
is: CHEBI:24636
name: trihexosyl ceramide
initial amount: NaN
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaM paps g
is: CHEBI:58339
constant: false
is: HMDB01134
type: Species
has only substance units: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

http://identifiers.org/biomodels.db/MODEL1310110041#_f939ee6a_ecd5_4e24_b941_8624a2a19f4b
is: Q08M29
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: GCNT2
is: SBO:0000252
is encoded by: hsa:2651
type: Species
boundary condition: true

metaR r0450
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110041#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39

metaR BGLUGCHe
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_12f8822e_8739_4287_b3a3_1ef09b4c4e67
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: MTHFS
constant: false
is encoded by: hsa:10588
initial amount: NaN
is: P49914
type: Species

metaR GLCMter
reversible: false
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: glucose transport via membrane vesicle

metaM glyb e
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00043
type: Species
name: glycine betaine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750

metaM ump r
has only substance units: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP
is: CHEBI:57865
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM chtn e
has only substance units: false
is: SBO:0000247
is: HMDB03362
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:17029
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
name: chitin
boundary condition: false

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110041#
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110041#

metaR RTOTAL2t
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR r0317
is: SBO:0000176
kinetic law: MODEL1310110041#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
is described by: ECO:0000000
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM 2maacoa m
initial amount: NaN
is: SBO:0000247
name: 2-methylacetoacetyl-CoA(4-)
constant: false
is: CHEBI:57335
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
is: HMDB01157
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_fe4a46c8_0350_462c_be80_88bc2227d62c
constant: false
boundary condition: true
is: SBO:0000252
is: B5MCC7
name: ACP1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:52

metaR r1615
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
fast: false
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_563f16ec_4f4c_4e9c_80af_aedc250a147b
is encoded by: hsa:570
initial concentration: NaN
constant: false
name: BAAT
is: Q14032
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR RE0452M
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#
name: RE0452
product: MODEL1310110041#
is: SBO:0000176
type: Reaction

metaR GTHPe
name: glutathione peroxidase (e)
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
reversible: true

metaM sph1p e
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
boundary condition: false
is: HMDB01383
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
initial concentration: 1.0
is: CHEBI:57939
initial amount: NaN

metaR INSTt4 2
is described by: ECO:0000006
reversible: true
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
name: inositol transport via sodium symport
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction

metaR PHETHPTOX2
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000269
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.14.16.1
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
is: SBO:0000176
reversible: false
type: Reaction
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)

http://identifiers.org/biomodels.db/MODEL1310110041#_20aaf478_5ba3_4e3a_8ea0_3f2211335119
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9ULD0
constant: false
initial amount: NaN
is encoded by: hsa:55753
has only substance units: false
boundary condition: true
name: OGDHL

metaM glc D c
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
is: CHEBI:4167
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB00122
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_319e466e_bc30_4fb7_88d5_882d42f9d737
constant: false
is: P12074
has only substance units: false
is encoded by: hsa:1337
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: COX6A1
type: Species
boundary condition: true

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaM dgtp c
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
name: dGTP
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16497
constant: false
is: C00286
is: HMDB01440
is: SBO:0000247

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_e05de9e6_5ace_497e_b79c_63b80883d902
is: O15270
type: Species
is encoded by: hsa:9517
name: SPTLC2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_13fdc1bc_99d4_4a23_9378_d168214216bf
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _U37519_1_c
is encoded by: hsa:U37519
initial amount: NaN

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM o2s n
type: Species
initial concentration: 1.0
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
initial amount: NaN
name: superoxide
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1ea029ad_68f6_40d9_a898_c45836f91150
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3032
is: P55084
name: HADHB

metaR r0399
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110041#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM hxan e
name: hypoxanthine
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
is: CHEBI:17368
is: HMDB00157
has only substance units: false
constant: false
initial amount: NaN

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ff12e67e_bc7e_47c5_8cd8_10f4f2db40c2
constant: false
name: LDHC
is: P07864
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:3948
initial concentration: NaN
initial amount: NaN

metaR GLUPRT
is version of: http://identifiers.org/ec-code/2.4.2.14
kinetic law: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
name: glutamine phosphoribosyldiphosphate amidotransferase
is: SBO:0000176
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reversible: false
fast: false

metaR r0714
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reversible: false

metaR r1616
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM 1p3h5c m
is: HMDB01369
is: CHEBI:6151
type: Species
constant: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR 25HVITD3t
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical
is described by: ECO:0000000
name: 25-hydroxyvitamin D3 transport from cytoplasm
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110041#

metaM CE0693 m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
type: Species
constant: false
initial amount: NaN
is: HMDB11123
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_a019b361_64cd_4c95_a813_b56d3b2590ea
is: O60476
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
name: MAN1A2
is encoded by: hsa:10905

metaM lpam m
name: lipoamide
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00962
has only substance units: false
is: SBO:0000247
is: CHEBI:17460
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248

http://identifiers.org/biomodels.db/MODEL1310110041#_a473cf4b_f3dc_4780_9340_e52262250c7a
constant: false
name: SOD1
is encoded by: hsa:6647
is: SBO:0000252
is: P00441
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_130084b8_4a14_41bb_8171_d130708959bc
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:476
constant: false
initial amount: NaN
has only substance units: false
name: ATP1A1
is: B7Z3U6

http://identifiers.org/biomodels.db/MODEL1310110041#_9580d796_5c23_4f9d_a864_4ae735368fd3
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:AI990637
name: _AI990637_1_x

metaM m8masn r
boundary condition: false
type: Species
is: C05876
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
notes: FORMULA: C70H117N2O55X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
initial amount: NaN
boundary condition: false
is: CHEBI:26174
constant: false
has only substance units: false
is: SBO:0000247
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial concentration: 1.0
type: Species

metaM lnlc r
is: CHEBI:30245
has only substance units: false
is: HMDB00673
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: linoleate
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2cfe34b9_4f0d_41c1_b549_be6e1e1b093f
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5148
initial amount: NaN
has only substance units: false
name: PDE6G
is: P18545
boundary condition: true
type: Species

metaM dtdp c
is: C00363
initial amount: NaN
initial concentration: 1.0
name: dTDP
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:58369
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274

metaR r1617
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#

metaR DATPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
name: dATP diffusion in nucleus
reactant: MODEL1310110041#
fast: false
type: Reaction

metaM glyb c
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00043
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: glycine betaine

metaM cala c
initial amount: NaN
constant: false
has only substance units: false
name: N-carbamoyl-beta-alaninate
initial concentration: 1.0
is: CHEBI:11892
type: Species
is: HMDB00026
boundary condition: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_48dc954e_c801_4382_978e_0c57bd725d68
name: SLC38A4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55089
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: Q969I6

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR NAt
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
name: sodium transport (uniport)
reversible: true
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:

metaM ksi pre17 g
is: CHEBI:28067
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM glc D e
is: CHEBI:4167
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00122
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM acgam l
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
name: N-acetyl-D-glucosamine
is: HMDB00215
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17411
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_59681742_7716_4c14_9e55_87e85647c52b
name: _FLJ44968_1_m
is encoded by: hsa:FLJ44968
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR RE1342C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110041#
is: SBO:0000176
name: RE1342
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
type: Reaction

metaR Htg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110041#
name: proton diffusion (Golgi)
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_12e807ec_f7b7_4b0e_b66f_652977259936
name: AKR1C4
has only substance units: false
is encoded by: hsa:1109
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P17516
constant: false
is: SBO:0000252

metaR r0795
reversible: false
fast: false
product: MODEL1310110041#
name: Spontaneous reaction
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
type: Reaction
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.225

http://identifiers.org/biomodels.db/MODEL1310110041#_93639b8d_0de0_420d_99b2_183539a79384
is encoded by: hsa:4668
boundary condition: true
name: NAGA
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: P17050
type: Species
has only substance units: false

metaM arachd e
initial concentration: 1.0
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
is: HMDB01043
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: arachidonate
has only substance units: false

metaM cit e
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16947
initial concentration: 1.0
is: HMDB00094
is: SBO:0000247
name: citrate(3-)
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaM hxan c
initial concentration: 1.0
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN
is: SBO:0000247
is: CHEBI:17368
has only substance units: false
is: HMDB00157
constant: false
boundary condition: false
name: Hypoxanthine
type: Species

metaR BTNPL
fast: false
is described by: ECO:0000000
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase)
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_8d718d34_3cbb_4fb3_a2d3_728090f37c6d
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: LDHD
initial amount: NaN
type: Species
is encoded by: hsa:197257
is: SBO:0000252

metaR B3GNT314g
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000254
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8fbacc32_b91e_4a70_a645_eccd52893db2
is: SBO:0000252
has only substance units: false
constant: false
is: Q8WZ48
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1374
initial amount: NaN
name: CPT1A

metaM galside hs e
is: SBO:0000247
is: CHEBI:12947
has only substance units: false
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
type: Species

metaM prostgh2 c
has only substance units: false
is: HMDB01381
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
type: Species
name: prostaglandin H2(1-)
is: CHEBI:57405
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r1618
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_b779b546_a0d6_47eb_8447_909945cedc99
has only substance units: false
boundary condition: true
is: P14415
initial concentration: NaN
is encoded by: hsa:482
is: SBO:0000252
constant: false
initial amount: NaN
name: ATP1B2
type: Species

metaM udp g
is: CHEBI:58223
initial amount: NaN
is: HMDB00295
boundary condition: false
has only substance units: false
name: UDP(3-)
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaM lnlc l
initial amount: NaN
type: Species
constant: false
name: linoleate
is: CHEBI:30245
is: HMDB00673
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
boundary condition: false
initial concentration: 1.0

metaR S6T6g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
product: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction

metaR DNDPt13m
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: false
name: dADP transport via ATP antiport
is: SBO:0000185
fast: false

metaM pro L m
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
is: HMDB00162
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: L-proline
constant: false

metaR q10tm
kinetic law: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110041#
name: transport of ubiquinone into mitochondria
fast: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_9cc90415_7f0a_4f30_9e70_c2d8604d06d4
initial concentration: NaN
constant: false
is encoded by: hsa:4144
boundary condition: true
has part: P31153
is encoded by: hsa:27430
is: SBO:0000297
has only substance units: false
type: Species
name: MAT2B:MAT2A
initial amount: NaN

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM dtdp e
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
is: CHEBI:58369
is: HMDB01274
boundary condition: false
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247

metaR r1611
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185

metaR r0796
reactant: MODEL1310110041#
is described by: ECO:0000000
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110041#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:

metaM ksi deg15 l
type: Species
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 15
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C160H257N11O140S8 CHARGE: -8

metaR r1551
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM ump n
has only substance units: false
initial amount: NaN
name: UMP(2-)
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaM arachd l
type: Species
boundary condition: false
is: HMDB01043
name: arachidonate
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_7dd506a2_a29d_4ab8_b177_f7850b2c6541
type: Species
name: SLC29A1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2030
constant: false
initial concentration: NaN
is: Q99808

metaR NCNt
fast: false
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
name: Na+/Ca2+-NH4+ exchange
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction

metaR r1090
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: false
is: SBO:0000185
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110041#

metaM prostgh2 e
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57405
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)
is: SBO:0000247
constant: false
is: HMDB01381
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_304752ee_2f6d_434c_b8ef_98c29fe793cb
has only substance units: false
is encoded by: hsa:1609
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: P52824
name: DGKQ
initial amount: NaN
boundary condition: true

metaR r0718
is version of: http://identifiers.org/ec-code/1.1.1.181
fast: false
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaM ala B c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
name: beta-alanine
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16958
is: HMDB00056
boundary condition: false
initial amount: NaN

MODEL1310110041
reaction: metaR r2324
reaction: metaR B3GNT35g
species: metaM HC01415 m
reaction: metaR r0267
species: metaM maltttr e
reaction: metaR MEOHt2
species: metaM ksi pre25 g
reaction: metaR ENGASE2ly
reaction: metaR sink 5hpet LPAREN c RPAREN
reaction: metaR r0392
species: metaM thf c
reaction: metaR PROSTGH2t
reaction: metaR TRPt
species: metaM cmpacna c
species: metaM leuktrC4 e
species: metaM g1p e
species: metaM dhor S c
reaction: metaR GLXtp
species: metaM 4abut c
reaction: metaR r0774
reaction: metaR S6T2g
reaction: metaR S6T17g
species: metaM Lcystin e
reaction: metaR r2017
species: metaM HC02175 e
species: metaM n2m2nmn l
species: metaM glyc R c
reaction: metaR EX for LPAREN e RPAREN
species: metaM chtn e
reaction: metaR r2320
reaction: metaR PPCDC
species: metaM retinal 11 cis c
species: metaM 10fthf m
reaction: metaR r0860
reaction: metaR r1642
species: metaM dolmanp U r
reaction: metaR DALAt2r
reaction: metaR r1702
species: metaM leuktrE4 e
species: metaM 3mop c
species: metaM nadph m
species: metaM alpro m
reaction: metaR CYOOm3
species: metaM sphgn c
species: metaM s2l2n2m2masn l
reaction: metaR EX Rtotal2 LPAREN e RPAREN
species: metaM gal l
species: metaM Rtotal3 e
species: metaM h2o e
reaction: metaR NTD5
reaction: metaR EX glyc S LPAREN e RPAREN
reaction: metaR B3GNT39g
species: metaM pheacgln e
reaction: metaR r0570
reaction: metaR RE3628M
species: metaM adp c
reaction: metaR DPCOAPPe
species: metaM o2 n
species: metaM ctp m
reaction: metaR r1554
reaction: metaR G14T4g
reaction: metaR EX o2 LPAREN e RPAREN
reaction: metaR EX q10 LPAREN e RPAREN
reaction: metaR r1109
reaction: metaR EX fe2 LPAREN e RPAREN
reaction: metaR RE3326M
reaction: metaR r2131
reaction: metaR FAOXC1811603m
species: metaM pe hs r
volume units: volume
reaction: metaR FACOAL140i
species: metaM hco3 e
reaction: metaR r2097
reaction: metaR S6T6g
reaction: metaR NACHEXA9ly
reaction: metaR DNDPt36m
species: metaM tyr L e
reaction: metaR FUCtly
reaction: metaR r1260
reaction: metaR r1259

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR r1612
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
fast: false

metaR 5HLTDL
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
product: MODEL1310110041#

metaR r0797
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000

metaM cit c
is: CHEBI:16947
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Citrate
boundary condition: false
initial amount: NaN
is: C00158
is: HMDB00094
has only substance units: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

http://identifiers.org/biomodels.db/MODEL1310110041#_b98ada44_8055_40c5_9d82_f3e999dcf0aa
is encoded by: hsa:117248
is: SBO:0000252
initial concentration: NaN
name: GALNTL2
initial amount: NaN
constant: false
is: Q8N3T1
type: Species
has only substance units: false
boundary condition: true

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_9fa8875e_24a0_40b3_a8a9_f07f7e4cc385
is encoded by: hsa:9107
boundary condition: true
type: Species
has only substance units: false
is: Q9Y217
initial amount: NaN
name: MTMR6
is: SBO:0000252
constant: false
initial concentration: NaN

metaR Asn X Ser Thrtr
name: Asn-X-Ser/Thr transport (from ER to lysosome)
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_0696e7f8_bb3a_458a_9047_3d4f257c90c4
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6185
is: P04844
type: Species
name: RPN2

metaM udp e
is: CHEBI:58223
initial amount: NaN
is: HMDB00295
boundary condition: false
has only substance units: false
name: UDP(3-)
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
constant: false

metaR B3GNT12g
reversible: false
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is described by: ECO:0000269
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176

metaR r0186
is: SBO:0000176
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000

metaR LPS4e
name: phospholipase
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.4
product: MODEL1310110041#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaM dhcholestanate c
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16577
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false

metaR PCt
reactant: MODEL1310110041#
name: phosphatidylcholine transporter
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.6.3.44
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
type: Reaction
product: MODEL1310110041#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_1a6bfa45_a86c_460d_ad32_62bb103a0009
is encoded by: hsa:84264
constant: false
is: SBO:0000252
has only substance units: false
name: HAGHL
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM ksi deg35 l
is: CHEBI:12936
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 35
is: SBO:0000247
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00143
initial concentration: 1.0

metaM Lkynr c
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
boundary condition: false
is: HMDB00684
name: L-kynurenine
is: CHEBI:16946
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaM g1m8mpdol U r
type: Species
is: CHEBI:59093
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
is: SBO:0000247
has only substance units: false
constant: false
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR r1553
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_12b6d26a_6755_46c4_a034_e33a33e47804
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q8WUX1
initial amount: NaN
name: SLC38A5
boundary condition: true
type: Species
constant: false
is encoded by: hsa:92745

metaR RE1807C
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
name: RE1807
fast: false

metaR r1613
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM ebastine r
initial amount: NaN
has only substance units: false
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
type: Species
name: ebastine
constant: false
boundary condition: false
is: CHEBI:211060
is: SBO:0000247
initial concentration: 1.0

metaR FK
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
name: Fucokinase
modifier: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.52
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction

metaM hco3 e
is: SBO:0000247
is: C00288
type: Species
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
initial concentration: 1.0
is: HMDB00595
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17544

metaM Tn antigen g
boundary condition: false
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
initial concentration: 1.0
is: C04383
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Tn antigen

metaM dgtp e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
type: Species
initial amount: NaN
is: CHEBI:16497
boundary condition: false
constant: false
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110041#_a8739d7c_1f4c_4e94_931e_ddbe42ec97af
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI348006
is: SBO:0000252
name: _AI348006_1_c
type: Species

metaR H2O2t
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
product: MODEL1310110041#
name: hydrogen peroxide transport via diffusion
type: Reaction
reactant: MODEL1310110041#
fast: false
reversible: true

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR r1614
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
is: SBO:0000185
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_91926b68_797d_4330_861e_9b33055d397e
is encoded by: hsa:57835
name: SLC4A5
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_aa608b5c_cd36_446e_8050_020cbf3ce8ab
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2582
is: SBO:0000252
constant: false
name: GALE
is: Q14376

metaM mmcoa R m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: SBO:0000247
name: (R)-methylmalonyl-CoA(5-)
has only substance units: false
is: CHEBI:57326
constant: false
initial concentration: 1.0
is: HMDB01269
initial amount: NaN
type: Species
boundary condition: false

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176

metaM udp c
is: HMDB00295
is: SBO:0000247
initial amount: NaN
is: C00015
has only substance units: false
constant: false
is: CHEBI:58223
initial concentration: 1.0
boundary condition: false
name: UDP
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR NDPK6m
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
modifier: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000254

metaR r1961
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
reversible: false
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR CYSO
is described by: ECO:0000269
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
name: cysteine oxidase
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT

metaR r1552
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110041#_e4d9b4e6_5384_4a37_8fbb_bfba92362748
is: SBO:0000252
name: ESPN
is: B1AK53
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:83715

http://identifiers.org/biomodels.db/MODEL1310110041#_fb02555d_d16a_4006_aa04_c688feaffcf6
initial amount: NaN
is: O15121
name: DEGS1
is encoded by: hsa:8560
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1dd13f06_6df4_4851_909f_9f724b774599
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1633
has only substance units: false
is: P27707
name: DCK
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_9ac208aa_22d5_4457_8f81_4b8a58fb3c88
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6482
initial amount: NaN
name: ST3GAL1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_4b99e797_ab1b_4404_85e8_3daab5e4e6f0
is encoded by: hsa:28976
is: Q9H845
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: ACAD9
boundary condition: true
type: Species

metaM pglyc hs e
name: phosphatidylglycerol(1-)
constant: false
is: CHEBI:60523
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

metaR r2095
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction

metaR RE0383C
modifier: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
name: RE0383
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#

metaM o2s x
name: superoxide
has only substance units: false
type: Species
is: CHEBI:18421
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
is: HMDB02168
boundary condition: false

metaM pchol hs e
is: SBO:0000247
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
constant: false
name: Phosphatidylcholine
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaM galgalgalthcrm hs e
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00143
boundary condition: false
is: C00124
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
type: Species
is: CHEBI:0
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_5c737bf5_4bff_4225_a625_cae9f2362136
boundary condition: true
is: SBO:0000252
is encoded by: hsa:64078
has only substance units: false
is: Q9HAS3
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC28A3
constant: false

metaR r0647
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
name: Spontaneous reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
fast: false

metaM 2hb c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
initial amount: NaN
type: Species
is: HMDB00008
constant: false
boundary condition: false
is: CHEBI:1148

http://identifiers.org/biomodels.db/MODEL1310110041#_7f9b1bec_36b8_47cd_b53b_b82e08c82962
initial concentration: NaN
is encoded by: hsa:AA526438
name: _AA526438_1_m
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_35d50fee_165a_4761_952f_944afe6000e2
is: SBO:0000252
is: Q9H2U2
initial concentration: NaN
name: PPA2
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:27068
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a53f015e_70af_4f3b_a736_8785d5fd3111
initial amount: NaN
name: NDUFB11
constant: false
is: Q9NX14
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:54539

http://identifiers.org/biomodels.db/MODEL1310110041#_f87a43e1_e169_49d9_9c75_3c3370702774
is encoded by: hsa:10455
is: SBO:0000252
is: O75521
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ECI2
constant: false

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: SBO:0000247
is: HMDB02052
is: CHEBI:17105
constant: false
type: Species
boundary condition: false
name: 4-maleylacetoacetate
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_5ab75470_0b1b_4977_a667_23483c878549
initial concentration: NaN
has only substance units: false
is encoded by: hsa:218
boundary condition: true
is: P30838
initial amount: NaN
name: ALDH3A1
is: SBO:0000252
constant: false
type: Species

metaR RE0566C
name: RE0566
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
fast: false
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_276a74a6_1273_44fa_924f_58405dd9665d
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:883
type: Species
is: Q16773
name: CCBL1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f60dde10_612c_41b7_974a_cdccb72fadf5
type: Species
initial concentration: NaN
boundary condition: true
name: COX4I1
is encoded by: hsa:1327
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P13073

metaM btcoa m
is: CHEBI:57371
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Butanoyl-CoA
is: C00136
type: Species
is: HMDB01088
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
boundary condition: false
constant: false

metaM maltttr e
name: Maltotetraose
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
type: Species
has only substance units: false
is: C02052
is: HMDB01296
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_5555ac47_2d87_454b_bb13_35437d6f547e
name: FUK
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:197258
is: Q8N0W3
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaM q10h2 m
name: Ubiquinol-10
constant: false
is: HMDB13111
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740

metaR GLYC St
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110041#
name: L-glycerate export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110041#
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110041#
name: cytidylate kinase (dCMP,CTP),nuclear
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_4ba71de6_0bab_4693_8c66_2bf14d83717e
initial concentration: NaN
boundary condition: true
constant: false
name: CHST2
is: Q9Y4C5
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:9435
initial amount: NaN

metaR Htr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110041#
is: SBO:0000185
name: H transporter, endoplasmic reticulum
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
is: SBO:0000185
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000

metaR LCADi D
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110041#
product: MODEL1310110041#
name: lactaldehyde dehydrogenase
is described by: ECO:0000304
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#

metaR SERPT
modifier: MODEL1310110041#
name: serine C-palmitoyltransferase
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.50
product: MODEL1310110041#
fast: false
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000269

metaR DAGt
reversible: true
name: diacylglycerol transport
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_d4f83bb2_6b4d_41d3_b304_db967051cee6
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:728226
name: _728226_1_m
has only substance units: false
is: SBO:0000252

metaR 4MOPt2im
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r1554
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM glcur l
boundary condition: false
is: SBO:0000247
is: HMDB00127
name: D-glucuronate
initial concentration: 1.0
is: CHEBI:15748
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
has only substance units: false

metaM gal14acglcgalgluside hs g
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Lactoneotetraosylceramide
constant: false
initial amount: NaN
is: CHEBI:17103
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110041#_8be8db6e_d0f1_4285_8dba_da83df95496c
is encoded by: hsa:2747
name: GLUD2
has only substance units: false
is: P49448
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_173a3fa5_62a0_4957_a8d0_42c3a73010e9
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:761
is: P07451
has only substance units: false
type: Species
initial concentration: NaN
name: CA3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_3f0352fb_fda2_4259_8f05_7ca1a065023b
initial concentration: NaN
is: SBO:0000252
name: SLC13A5
is encoded by: hsa:284111
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: Q86YT5
has only substance units: false

metaM pyr c
is: SBO:0000247
is: HMDB00243
name: pyruvate
constant: false
boundary condition: false
has only substance units: false
is: C00022
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
type: Species
initial amount: NaN

metaM glyb m
constant: false
has only substance units: false
name: glycine betaine
type: Species
is: HMDB00043
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
is: CHEBI:17750
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM acgam r
is: CHEBI:17411
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00215
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
name: N-acetyl-D-glucosamine

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial concentration: 1.0
is: CHEBI:61648
initial amount: NaN
has only substance units: false
name: VI2Fuc-nLc6
constant: false

metaM 4mop c
initial concentration: 1.0
boundary condition: false
name: 4-methyl-2-oxopentanoate
is: HMDB00695
initial amount: NaN
is: SBO:0000247
is: CHEBI:17865
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

http://identifiers.org/biomodels.db/MODEL1310110041#_417a8da0_72d2_4ec7_b479_b3e26d225f8f
is encoded by: hsa:4707
name: NDUFB1
boundary condition: true
is: O75438
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: CHEBI:61648
has only substance units: false
constant: false
type: Species

metaM acngalgbside hs g
initial concentration: 1.0
is: CHEBI:16523
is: HMDB03406
name: sialyl galactosylgloboside
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1

metaR r1557
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110041#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110041#

metaR r2093
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110041#
product: MODEL1310110041#

metaM pglyc hs c
boundary condition: false
is: CHEBI:60523
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
name: phosphatidylglycerol(1-)
has only substance units: false

metaR SUCCtp
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: succinate transporter, peroxisome
fast: false

metaM glgchlo e
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN
name: beta glucan-glycocholate complex
is: CHEBI:57449

metaM 2hb e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
initial amount: NaN
is: HMDB00008
constant: false
type: Species
is: SBO:0000247
is: CHEBI:1148
boundary condition: false

metaM pchol hs c
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: Phosphatidylcholine
is: SBO:0000247
is: CHEBI:16110
constant: false
has only substance units: false
type: Species
boundary condition: false

metaM galgalgalthcrm hs c
boundary condition: false
constant: false
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
type: Species
is: HMDB00143
has only substance units: false
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM ksi pre18 g
is: C00130
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
has only substance units: false
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 18
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
constant: false
type: Species
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110041#_7fe19889_5dd1_42e9_ac71_87410978a6ec
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: NDUFV3
is encoded by: hsa:4731
is: P56181
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_57c7ef0c_b3bc_4ec7_a76f_e5c4f886e086
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: Q92819
type: Species
is encoded by: hsa:3037
initial concentration: NaN
name: HAS2

metaM ump g
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
is: HMDB00288
name: UMP(2-)
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_49637523_3481_4259_b1b9_d31fa0f6f15e
has only substance units: false
boundary condition: true
name: SLC35C1
is encoded by: hsa:55343
type: Species
is: B3KQH0
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a35e9454_f0fd_4636_bbe5_bfb21979d2a8
initial amount: NaN
name: _7359_1_c
constant: false
is encoded by: hsa:7359
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM amp x
is: C00020
is: CHEBI:456215
is: HMDB00045
name: AMP
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

metaR ALADGLNexR
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000304
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: L-alanine/glutamine reversible exchange

metaR r2094
is described by: ECO:0000000
product: MODEL1310110041#
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1556
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_16b9a5de_e956_4371_b553_0add34c277f5
boundary condition: true
has only substance units: false
is: O95992
initial amount: NaN
name: CH25H
is: SBO:0000252
constant: false
is encoded by: hsa:9023
type: Species
initial concentration: NaN

metaR HYXNt
type: Reaction
modifier: MODEL1310110041#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110041#
name: Hypoxanthine transport
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv

metaR 4MPTNLte
is: SBO:0000185
name: 4-methylpentanal transport
reactant: MODEL1310110041#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

metaR CYANt
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
name: Cyanide transport via diffusion (extracellular to cytosol)
product: MODEL1310110041#

metaM srtn e
has only substance units: false
initial concentration: 1.0
name: serotonin(1+)
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:350546
is: HMDB00259
type: Species
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

http://identifiers.org/biomodels.db/MODEL1310110041#_a901cbb7_24e2_4e62_b8a1_4ce5c38c5a14
constant: false
initial concentration: NaN
is: Q96FL9
name: GALNT14
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79623
type: Species

metaR RE0565C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
name: RE0565
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_cfbd3e6c_8f7e_4fbd_8a56_ecbf443197c5
constant: false
name: _H77542_1_c
is encoded by: hsa:H77542
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR 3MOPt2im
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
reversible: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR ACGAMK
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.59
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: false
name: N-acetylglucosamine kinase
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
product: MODEL1310110041#
is: SBO:0000176

metaM 2dr1p c
is: HMDB01351
type: Species
is: C00672
is: CHEBI:58576
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
name: 2-Deoxy-D-ribose 1-phosphate

metaM cit m
is: C00158
is: HMDB00094
boundary condition: false
initial amount: NaN
name: Citrate
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
type: Species
is: CHEBI:16947
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_6c4c47d6_554c_4c82_a91d_b55f27be1c51
initial amount: NaN
initial concentration: NaN
has part: P23378
is encoded by: hsa:275
is: SBO:0000297
is encoded by: hsa:2731
boundary condition: true
has part: P23434
constant: false
has part: P48728
has only substance units: false
type: Species
is encoded by: hsa:2653
name: DLD:GCSH:GLDC:AMT

metaM pyr e
is: SBO:0000247
is: HMDB00243
type: Species
is: CHEBI:15361
constant: false
name: pyruvate
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR RNDR1
reversible: false
name: ribonucleoside-diphosphate reductase (ADP)
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
type: Reaction

metaR r0208
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.4.1.1
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is described by: ECO:0000000
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
product: MODEL1310110041#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_82a6e1c1_e260_484b_8bc0_8ea440140fa7
is: P39656
is encoded by: hsa:1650
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DDOST
type: Species
initial amount: NaN
constant: false

metaR r1619
kinetic law: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
reversible: true
type: Reaction
modifier: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_5d1ff1b5_45ad_4e3a_a305_d5fae023ab36
is: SBO:0000297
has only substance units: false
constant: false
name: SUCLG1:SUCLA2
has part: E5KS60
initial amount: NaN
is encoded by: hsa:8803
boundary condition: true
type: Species
initial concentration: NaN

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM ocdcea e
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
is: HMDB00207
is: SBO:0000247
is: C00712
constant: false
initial amount: NaN
name: octadecenoate (n-C18:1)
type: Species
initial concentration: 1.0
is: CHEBI:0

metaR ILEt5m
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: Isoleucine mitochondrial transport
product: MODEL1310110041#

metaR r1559
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_31b57ed3_cdb9_45af_afe6_a2f48fbaef7d
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4645
is: Q9H6Y6
initial concentration: NaN
name: MYO5B
has only substance units: false
type: Species
initial amount: NaN

metaR r2010
reactant: MODEL1310110041#
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false

metaM 2mb2coa m
name: 2-methylcrotonoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
initial amount: NaN
is: HMDB02054
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57337
constant: false
type: Species

metaM Tn antigen l
initial concentration: 1.0
has only substance units: false
type: Species
is: C04383
initial amount: NaN
constant: false
name: Tn antigen
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H14NO5X CHARGE: 0

metaM acglcgal14acglcgalgluside hs g
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
name: nLc5Cer
initial amount: NaN
is: CHEBI:17103
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM mi4p D c
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
has only substance units: false
initial amount: NaN
boundary condition: false
name: 1D-myo-inositol 4-phosphate(2-)
is: HMDB01313
initial concentration: 1.0
is: CHEBI:58469

metaR PRGNLONEtm
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reversible: true
name: pregnenolone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
reactant: MODEL1310110041#

metaM ump e
is: CHEBI:57865
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
name: UMP(2-)
type: Species

metaR GGH 7DHFl
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110041#
reversible: false
product: MODEL1310110041#
type: Reaction

metaM srtn c
is: CHEBI:350546
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: serotonin(1+)
initial concentration: 1.0
is: HMDB00259
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_a14c38f2_b1f9_4698_b17c_d13315c5c5ef
initial amount: NaN
constant: false
is encoded by: hsa:204
is: P54819
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: AK2
has only substance units: false

metaM HC02210 c
initial concentration: 1.0
name: prostaglandin-d3
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
is: CHEBI:34939
type: Species
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_231e1e15_2fd3_403e_9718_af62a6d57788
type: Species
name: CTPS2
initial amount: NaN
has only substance units: false
is: Q9NRF8
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:56474

metaR r2092
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110041#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaM itp c
is: CHEBI:57614
type: Species
name: ITP(3-)
is: HMDB00189
is: SBO:0000247
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR RE3004M
name: RE3004
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM arachd c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01043
name: arachidonate

metaM ksi pre25 g
type: Species
is: SBO:0000247
is: C00130
name: keratan sulfate I biosynthesis, precursor 25
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
boundary condition: false
is: CHEBI:58053
is: HMDB00175
constant: false

metaM ksii core2 pre10 g
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
type: Species
constant: false
name: keratan sulfate II biosynthesis, precursor 10
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
boundary condition: false
initial amount: NaN

metaM ps hs e
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
is: CHEBI:18303
initial concentration: 1.0
constant: false

metaR r0644
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
reversible: true

metaR Htm
modifier: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (9016.1) or (7352.2) or (7352.1) or (7351.1) or (9016.2) or (7350.1) or (9481.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
fast: false
reactant: MODEL1310110041#
name: Uncoupling protein
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_31d2f446_fc3f_435d_bde3_0628f9c0f443
is: Q9NT06
initial amount: NaN
name: HMGCLL1
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:54511
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_10b9e340_5823_4175_9736_72da9120d1d6
name: ABCD1
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P33897
is encoded by: hsa:215
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_9f3b67e7_56e4_4e40_a5a5_1dd34d829519
type: Species
name: PLCH1
boundary condition: true
is: SBO:0000252
is: Q4KWH8
is encoded by: hsa:23007
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0181
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
modifier: MODEL1310110041#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5

metaM udp n
is: CHEBI:58223
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00295
has only substance units: false
boundary condition: false
name: UDP(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_964a1ec8_de33_4467_87e9_96be72155fc3
initial amount: NaN
name: DPM1
is encoded by: hsa:8813
is: O60762
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaM prpncoa m
is: SBO:0000247
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial amount: NaN
is: HMDB02307
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: acryloyl-CoA(4-)
is: CHEBI:57367

http://identifiers.org/biomodels.db/MODEL1310110041#_813b13e0_ff5c_47f3_9f5e_da356ca95d1e
name: UROS
is encoded by: hsa:7390
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P10746
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_3889b8d1_5fcf_443b_8e46_2bb8ddcb2dc9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6487
boundary condition: true
has only substance units: false
type: Species
name: ST3GAL3
constant: false
initial concentration: NaN

metaR PCm
name: pyruvate carboxylase
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/6.4.1.1
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance

http://identifiers.org/biomodels.db/MODEL1310110041#_c34250eb_825a_471e_8c13_fa40fe45d402
constant: false
has only substance units: false
name: RDH11
initial amount: NaN
is: B4DDW0
is encoded by: hsa:51109
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR ADSK
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110041#
name: adenylyl-sulfate kinase
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000269
reactant: MODEL1310110041#
reversible: false
product: MODEL1310110041#

metaR GLYCTO1p
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110041#
name: Glycolate oxidase, peroxisome
is version of: http://identifiers.org/ec-code/1.1.3.15
reversible: false
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
fast: false

metaR ALAGLNexR
name: L-alanine/glutamine reversible exchange
is described by: ECO:0000304
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaM ocdcea c
has only substance units: false
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: SBO:0000247
is: C00712
type: Species
constant: false
initial amount: NaN
is: CHEBI:0

metaM 4hglusa m
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial amount: NaN
name: L-4-hydroxyglutamic semialdehyde
is: CHEBI:27809
is: SBO:0000247
type: Species
is: HMDB06556

metaM ksi deg41 l
initial amount: NaN
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C34H58N2O26 CHARGE: 0
name: keratan sulfate I, degradation product 41
initial concentration: 1.0
is: HMDB00143
constant: false

metaM h x
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636
type: Species
boundary condition: false
is: SBO:0000247
is: C00080
name: proton
has only substance units: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

http://identifiers.org/biomodels.db/MODEL1310110041#_92e98cf1_dd7c_492e_8350_c29c5294ddb1
name: ENTPD3
initial concentration: NaN
initial amount: NaN
is: O75355
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:956

metaR RETH2e
name: retinyl ester hydrolase (11-cis), extracellular
fast: false
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR r0456
reversible: false
product: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
reactant: MODEL1310110041#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000000

metaR r2012
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR G14T2g
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110041#_f977cdda_352b_4a87_87c1_58b95bfc9b85
name: ACO1
is: SBO:0000252
constant: false
type: Species
is: P21399
boundary condition: true
is encoded by: hsa:48
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_745161a5_dc7c_49a9_8ff2_1a546f662b4f
has only substance units: false
constant: false
name: PYCR1
is: A6NFM2
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5831
initial concentration: NaN

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r0287
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110041#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_d9d2db3d_bca7_41f9_8aca_5b423ccbf6f7
has only substance units: false
is: Q99624
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC38A3
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:10991

http://identifiers.org/biomodels.db/MODEL1310110041#_a435cf25_3525_4a53_ae79_9fa48131236e
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HPRT1
boundary condition: true
is encoded by: hsa:3251
constant: false
is: P00492

http://identifiers.org/biomodels.db/MODEL1310110041#_715616aa_bae0_407f_b425_472719bf4979
constant: false
initial amount: NaN
boundary condition: true
is: P43251
is: SBO:0000252
has only substance units: false
name: BTD
is encoded by: hsa:686
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_e3197f0a_ed10_423e_b674_8486d8ffc0e7
is: Q9NQR4
constant: false
has only substance units: false
name: NIT2
is encoded by: hsa:56954
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_4e01bfd6_4805_44f0_b906_099d69670d78
name: B3GALT5
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:10317
has only substance units: false
initial amount: NaN

metaR MANtg
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110041#
name: mannose efflux from Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false

metaR CYTK9n
modifier: MODEL1310110041#
name: cytidylate kinase (CMP,dCTP),nuclear
product: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM mn l
boundary condition: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
name: beta-1,4-mannose-N-acetylglucosamine
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06535

http://identifiers.org/biomodels.db/MODEL1310110041#_8bb0d737_560a_4813_9335_423086acc855
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55350
constant: false
type: Species
name: VNN3
initial amount: NaN
initial concentration: NaN

metaM ump c
is: C00105
is: CHEBI:57865
name: UMP
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
is: HMDB00288
has only substance units: false
type: Species

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaR KCCt
kinetic law: MODEL1310110041#
name: K+-Cl- cotransport
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
product: MODEL1310110041#
fast: false

metaM CE0713 m
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: HMDB02329
name: 3-oxolinoleoyl-CoA
boundary condition: false
is: CHEBI:30623
has only substance units: false
constant: false
is: SBO:0000247

metaR r2090
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110041#
type: Reaction

metaR 3HKYNAKGAT
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000304
is: SBO:0000176

metaM itp e
name: ITP(3-)
is: HMDB00189
has only substance units: false
is: CHEBI:57614
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaR LEUt5m
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
name: leucine mitochondrial transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110041#

metaR r2011
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_4952171f_f1d4_4ab4_8d65_5ca85b003b9a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: GLRX2
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:51022
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e76492cb_5aa3_4364_9dd0_4a29197e9bf6
is: Q86U05
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:23428
is: SBO:0000252
name: SLC7A8
type: Species
constant: false

metaM ps hs c
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18303
name: ps_hs[c]

metaM ca2 e
type: Species
is: SBO:0000247
is: HMDB00464
has only substance units: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: calcium(2+)

metaM hco3 m
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
is: C00288
is: CHEBI:17544
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00595
boundary condition: false
type: Species

metaM 4mop e
constant: false
is: HMDB00695
initial amount: NaN
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
has only substance units: false
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
is: SBO:0000247
boundary condition: false

metaM sph1p c
is: CHEBI:57939
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120

metaM udp l
is: HMDB00295
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
boundary condition: false
has only substance units: false
name: UDP(3-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaR S2L2N2M2MASNtly
fast: false
name: s2l2n2m2masn transport, extracellular to lysosome
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction

metaM ksi pre7 g
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 7
boundary condition: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: C00130
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175

metaR r0791
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110041#
reversible: true
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
is described by: ECO:0000000
type: Reaction

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR r0074
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaM 3hbcoa m
is: SBO:0000247
constant: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: HMDB01166
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57316
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144

metaR LPCOXp
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is version of: http://identifiers.org/ec-code/1.5.3.1
name: L-pipecolate oxidase, peroxisomal
fast: false
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110041#

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_91c2c0b4_f9e0_40e2_bc08_64cd6c59d781
initial concentration: NaN
has part: P08195
constant: false
name: SLC7A10:SLC3A2
is encoded by: hsa:6520
is: SBO:0000297
has part: Q9NS82
boundary condition: true
initial amount: NaN
is encoded by: hsa:56301
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4d205786_a605_4def_8995_6dcbc5778fbf
constant: false
type: Species
is encoded by: hsa:10327
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P14550
initial concentration: NaN
name: AKR1A1
has only substance units: false

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_cab15686_d167_4c43_9eb8_8e202d5d83d0
boundary condition: true
is encoded by: hsa:5152
name: PDE9A
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_9ff96e4b_c18a_4b22_bd33_dab57f45b33e
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:124
constant: false
is: P07327
boundary condition: true
name: ADH1A
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_cda64bec_dc5f_444f_9877_caa87be897ec
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q9UBX3
name: SLC25A10
is encoded by: hsa:1468
is: SBO:0000252
type: Species

metaM 4abut c
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
initial amount: NaN
is: CHEBI:3628
boundary condition: false
is: SBO:0000247
name: 4-Aminobutanoate
type: Species
has only substance units: false
is: C00334
initial concentration: 1.0

metaR TCYNTtm
fast: false
reversible: false
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
kinetic law: MODEL1310110041#
name: Thiocyanate transport via diffusion (mitochondrial)
is described by: ECO:0000000

metaM cyan e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false
type: Species
name: hydrogen cyanide
constant: false
is: HMDB02084
is: CHEBI:18407

metaM uacgam g
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
is: CHEBI:57705
constant: false
boundary condition: false
initial amount: NaN

metaR KSII CORE4t
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
name: keratan sulfate II (core4) transport, golgi to extracellular
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

metaR UDPACGALtl
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: udpacgal intracellular transport
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM ca2 c
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:29108
name: calcium(2+)
initial concentration: 1.0
is: SBO:0000247
is: HMDB00464
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

http://identifiers.org/biomodels.db/MODEL1310110041#_e0bd1593_498f_41fb_9ed5_7c72d30bfd46
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: _W74642_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:W74642

metaR MG2er
fast: false
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#

metaR P45011A1m
is version of: http://identifiers.org/ec-code/1.14.15.6
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reversible: false
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_b56a10c9_6287_434b_92cb_0c57675d1385
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: HAS3
has only substance units: false
is: O00219
is encoded by: hsa:3038
is: SBO:0000252

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_f3116e4e_eaca_47c8_a36c_52db81c9d13b
has only substance units: false
is: P11908
is encoded by: hsa:5634
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PRPS2
type: Species

metaM CE1925 e
initial concentration: 1.0
type: Species
is: CHEBI:12947
has only substance units: false
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
boundary condition: false
initial amount: NaN
constant: false
name: 3'-carboxy-alpha-chromanol
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_6c618eda_7de3_4cb9_a4ef_f2cd628a09cb
is: SBO:0000252
is encoded by: hsa:1743
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: DLST
is: P36957

http://identifiers.org/biomodels.db/MODEL1310110041#_0b64b01f_b085_4ffc_ad64_f59647f74c67
is encoded by: hsa:27306
name: HPGDS
constant: false
boundary condition: true
is: O60760
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM din c
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
is: HMDB00071
is: CHEBI:28997
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: Deoxyinosine
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r1660
modifier: MODEL1310110041#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM air c
is: SBO:0000247
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species
is: C03373
is: CHEBI:58592
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01235
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_047a1342_3a49_4502_a451_18664d6c725e
is: B7Z4Y6
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: ALPL
is encoded by: hsa:249
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_0eebec97_ebd7_4148_b902_c787e8570fd0
initial concentration: NaN
is: Q96SL4
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: GPX7
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2882

http://identifiers.org/biomodels.db/MODEL1310110041#_e1802aa4_14bb_44be_b5f9_99e6e6eb5c85
constant: false
is encoded by: hsa:158
name: ADSL
is: P30566
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

metaM pchol hs m
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: Phosphatidylcholine
is: CHEBI:16110

http://identifiers.org/biomodels.db/MODEL1310110041#_d89d5b55_baa1_4dc7_927d_420bdd8e4bcf
name: GALNT2
constant: false
is: SBO:0000252
is: Q10471
type: Species
is encoded by: hsa:2590
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_72277ffa_cb60_47d3_bacf_8cc80f55b37d
has only substance units: false
type: Species
initial amount: NaN
name: DPYSL3
boundary condition: true
constant: false
is encoded by: hsa:1809
initial concentration: NaN
is: SBO:0000252
is: Q8IXW6

metaR RE3245C
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
is: SBO:0000176
name: RE3245
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_6c305195_e709_4935_b0b0_e7eab4a57d98
is: Q99487
name: PAFAH2
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:5051
initial concentration: NaN

metaM thcholstoic c
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
initial amount: NaN

metaR CITL
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
name: Citrate lyase
reversible: false
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_3490b485_3307_44a5_aa9d_93ea4fdd1358
is: Q96FY7
is: SBO:0000252
has only substance units: false
constant: false
name: ACSS2
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55902

metaR ACHtn
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
fast: false
reversible: true
reactant: MODEL1310110041#
type: Reaction
name: Acetylcholin transport, nuclear trhough pores

http://identifiers.org/biomodels.db/MODEL1310110041#_41045581_426a_4a9d_9b20_28a375662fbd
is encoded by: hsa:8704
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: B4GALT2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_404afada_867e_4120_877e_5bb0818febe5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PPA2
has only substance units: false
type: Species
is encoded by: hsa:27068
boundary condition: true
constant: false
is: F8WDN9

http://identifiers.org/biomodels.db/MODEL1310110041#_f5347397_532d_45be_87b3_ce62937a1469
constant: false
is encoded by: hsa:230
initial concentration: NaN
boundary condition: true
is: P09972
name: ALDOC
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR UMPKn
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: UMP kinase, nuclear
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_2fe4f36a_3686_4c7e_8b43_9aa54c54f39f
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:956
is: O75355
name: ENTPD3
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM 4abut e
has only substance units: false
initial concentration: 1.0
is: HMDB00112
initial amount: NaN
is: CHEBI:3628
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
type: Species
is: C00334
name: 4-Aminobutanoate
constant: false

metaM acglcgalgluside hs g
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
boundary condition: false
type: Species
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17103
constant: false
is: SBO:0000247

metaM arachcoa c
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: arachidyl coenzyme A
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:15527
is: HMDB04258

metaM pyr m
boundary condition: false
type: Species
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
is: SBO:0000247
is: CHEBI:15361
is: C00022
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
is: HMDB00243
has only substance units: false
initial concentration: 1.0

metaM ksi pre30 g
is: HMDB00175
type: Species
is: C00130
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 30
constant: false
boundary condition: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10

metaR r1661
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction

metaM cyan c
initial concentration: 1.0
name: hydrogen cyanide
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02084
constant: false
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false
boundary condition: false

metaR r0642
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true

metaR SBT Dtde
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000134
name: D-sorbitol transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
kinetic law: MODEL1310110041#
reversible: true

metaR GTHP
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.11.1.15
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.11.1.12
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110041#
name: glutathione peroxidase
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a97cc4cb_6d46_452e_b5cf_728f433bd7eb
initial concentration: NaN
is encoded by: hsa:642502
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: _642502_1_c

metaR Htx
type: Reaction
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110041#
fast: false
name: H transporter, peroxisome

metaM HC02210 e
is: CHEBI:34939
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
name: prostaglandin-d3

http://identifiers.org/biomodels.db/MODEL1310110041#_e98c543b_d30d_4bb5_9c5e_9304b57c9645
has only substance units: false
is: SBO:0000252
is: Q5TDP6
initial amount: NaN
name: LGSN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:51557
boundary condition: true

metaR VITD3Hm
fast: false
modifier: MODEL1310110041#
is: SBO:0000176
reversible: false
product: MODEL1310110041#
name: Vitamin D-25-hydroxylase (D3)
reactant: MODEL1310110041#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:7690968 NOTES:based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT; RE1303M
type: Reaction
kinetic law: MODEL1310110041#

metaM din e
is: CHEBI:28997
initial concentration: 1.0
is: HMDB00071
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
boundary condition: false
name: Deoxyinosine
has only substance units: false
is: C05512
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR DURAD
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.1.2
is described by: ECO:0000269
fast: false
reversible: true
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: dihydrouracil dehydrogenase (NADP)
type: Reaction
is: SBO:0000176
product: MODEL1310110041#

metaR ALAt2r
is described by: ECO:0000304
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
name: L-alanine reversible transport via proton symport
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true

metaR TSTSTERONEtr
name: testosterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r1662
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5a61e458_5583_43b3_8151_66216967fcc7
is: SBO:0000252
name: AMY1B
is: P04745
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:277
type: Species

metaR r0641
fast: false
reversible: true
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
modifier: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c8ed97da_06b0_4cc6_8012_5dde26176a94
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA854479
name: _AA854479_1_m

metaM ru5p D c
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58121
name: D-ribulose 5-phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618

metaR UPPN
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
type: Reaction
name: b-ureidopropionase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_509a5bc0_b558_45b8_a015_ab99bac5833e
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:T83654
constant: false
name: _T83654_1_m
boundary condition: true
is: SBO:0000252

metaM methf c
type: Species
boundary condition: false
initial concentration: 1.0
name: 5,10-Methenyltetrahydrofolate
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
has only substance units: false
is: C00445
initial amount: NaN
is: HMDB01354
constant: false

metaR GTHO
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110041#
fast: false
reversible: false
product: MODEL1310110041#
name: glutathione oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is version of: http://identifiers.org/ec-code/1.8.1.7

http://identifiers.org/biomodels.db/MODEL1310110041#_dde4ec07_2eb8_49aa_b5bc_a4337d2320ea
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O43252
is encoded by: hsa:9061
has only substance units: false
name: PAPSS1
constant: false

metaR GALt4
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110041#
reversible: true
fast: false
product: MODEL1310110041#
modifier: MODEL1310110041#
name: galactose transport via sodium symport
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_7fcb8321_465e_485f_aa7e_66471d7db4d7
name: NDUFA10
boundary condition: true
type: Species
constant: false
is: O95299
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4705
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c714159a_4d2b_4528_87b2_af764ec6405a
initial concentration: NaN
is encoded by: hsa:30
name: ACAA1
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: Q96CA6
constant: false

metaR ALAGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110041#
is described by: ECO:0000304
type: Reaction
name: L-alanine/glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false

metaR PIt7
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
name: phosphate transport in/out via three Na+ symporter
type: Reaction
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000269

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
is described by: ECO:0000269
name: bilirubin transport via bicarbonate countertransport
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185

metaR r2005
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
reversible: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_39b3a9a5_271b_4a6f_98a0_be224d03ac62
is: SBO:0000252
name: COX1
initial amount: NaN
is: Q7GXY8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4512
has only substance units: false

metaM crm hs e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52639
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
has only substance units: false
name: N-acylsphingosine

metaM pchol hs r
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
is: CHEBI:16110
initial concentration: 1.0
name: Phosphatidylcholine
constant: false

metaR MTHFD2
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#
is described by: ECO:0000134
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176

metaR ENGASEly
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110041#
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110041#
is described by: ECO:0000000
reversible: false

metaR FADDPle
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
name: FAD diphosphatase
is described by: ECO:0000134

metaM HC02202 e
is: CHEBI:57398
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
has only substance units: false
name: prostaglandin A1(1-)
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR HACD1m
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is: SBO:0000176
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
fast: false
reversible: true
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_df359c65_05db_433b_b9b9_63051ce2f184
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:206358
name: SLC36A1
type: Species
is: Q1LZ56
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_999b0d9e_d7d4_431c_bbbd_1becca9c84e7
is: Q59EA4
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:5337
name: PLD1
is: SBO:0000252

metaM m6masnC g
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01356
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: CHEBI:57312

metaR r2380
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_22280d55_2283_460c_b06d_ac14be156c91
boundary condition: true
type: Species
name: NT5C2
initial concentration: NaN
is: P49902
is encoded by: hsa:22978
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaR RE1709N
type: Reaction
modifier: MODEL1310110041#
name: RE1709
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f32deedd_5df7_46e7_acbe_10aa88aba823
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: DHODH
has only substance units: false
constant: false
is: Q02127
type: Species
is: SBO:0000252
is encoded by: hsa:1723

metaR PIt8
is described by: ECO:0000006
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
fast: false
product: MODEL1310110041#
is: SBO:0000185
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
modifier: MODEL1310110041#

metaR G14T20g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR G12MT1 U
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#

metaR 2HBO
reactant: MODEL1310110041#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
reversible: true
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_db829ccf_151d_4d25_8b83_93626aa5f783
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:34
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P11310
name: ACADM

metaM abt c
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
is: SBO:0000247
is: CHEBI:18403

http://identifiers.org/biomodels.db/MODEL1310110041#_52a89a5c_85db_44c0_a573_24b2ed4d89de
is encoded by: hsa:10965
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: ACOT2
boundary condition: true
is: P49753

metaR SRTNt6 2 r
type: Reaction
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110041#
is: SBO:0000185
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
reversible: true

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM ebastine e
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
name: ebastine
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:211060
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_49b1719e_75e6_40da_8952_4cd557d81a2a
name: SDHB
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: P21912
is encoded by: hsa:6390
constant: false
is: SBO:0000252
initial concentration: NaN

metaM o2s c
has only substance units: false
initial concentration: 1.0
is: CHEBI:18421
is: HMDB02168
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
name: superoxide

metaR GGT6
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000176
name: Gamma-glutamyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_067ee44f_e2a7_427a_9f30_4f96e9c61bc3
constant: false
is: Q16348
has only substance units: false
name: SLC15A2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6565
initial amount: NaN
type: Species

metaM gdpfuc c
boundary condition: false
is: CHEBI:57984
initial amount: NaN
type: Species
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
initial concentration: 1.0
is: HMDB01095
is: SBO:0000247
constant: false

metaR G16MT U
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110041#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR ADK1
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: adenylate kinase
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#

metaR VALt5m
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
name: Valine reversible mitochondrial transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

metaR r2099
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_593e3343_12ab_4a60_9c7f_00404d7ee9c6
is encoded by: hsa:3145
name: HMBS
has only substance units: false
is: P08397
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR r2381
reversible: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_d7871b19_4b4d_408b_b426_e444f9635a8e
name: IK
boundary condition: true
is: Q13123
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:3550

metaM crm hs c
is: SBO:0000247
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: N-acylsphingosine
initial concentration: 1.0

metaR RPEc
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000134
reversible: true
name: ribulose 5-phosphate 3-epimerase
type: Reaction
product: MODEL1310110041#
is: SBO:0000176

metaM CE2433 m
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false
is: C01936
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5d3d15bd_c28a_46cd_995c_246be63a3ec9
name: GPD1
is encoded by: hsa:2819
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: F8W1L5
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_0208d4d7_b529_4d66_a10b_f34e23a4a3fd
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: A6NED0
is encoded by: hsa:2954
has only substance units: false
type: Species
name: GSTZ1

http://identifiers.org/biomodels.db/MODEL1310110041#_fec4002b_13c1_4cd3_b71f_69e39c79d13b
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:217
name: ALDH2
is: P05091
is: SBO:0000252
initial concentration: NaN

metaR ITCOALm
product: MODEL1310110041#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
kinetic law: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
reactant: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction

metaM HC02202 c
type: Species
has only substance units: false
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false

metaM m8masn g
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: C05876
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c9876557_d0c9_46c8_8bed_b37cd45ef942
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: VNN3
is encoded by: hsa:55350
boundary condition: true

metaR P45027A1m
product: MODEL1310110041#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: Cytochrome P450 27
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_748570c5_0df7_45fd_9da3_62c83ba7b276
name: CHAT
initial concentration: NaN
is: Q6LEN5
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:1103

metaR r0941
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
kinetic law: MODEL1310110041#
name: Free diffusion
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_13156aee_b684_4518_8e73_cd50156aa5ae
is: A6H8L5
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3990
initial concentration: NaN
type: Species
initial amount: NaN
name: LIPC

metaM nadp c
is: HMDB00217
has only substance units: false
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
is: C00006
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: CHEBI:58349

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_f6e9d982_a32f_45ca_8fd3_aad477257b2a
is encoded by: hsa:6580
name: SLC22A1
is: O15245
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_82122507_4f10_4298_8b8c_917f25fef010
constant: false
is: SBO:0000252
is: P00374
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1719
name: DHFR

metaR r2382
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110041#

metaR LNLCCPT1
name: carnitine O-palmitoyltransferase
product: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
fast: false
type: Reaction

metaR AG13T5g
reversible: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000

metaR r2098
reactant: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
fast: false
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_0a16be84_fac4_4de4_a708_3f25192774b1
is encoded by: hsa:H53099
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: _H53099_1_m

http://identifiers.org/biomodels.db/MODEL1310110041#_28e09fee_d782_414a_8d25_70888002b2a2
name: _AA021081_1_r
constant: false
type: Species
is encoded by: hsa:AA021081
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_151dfbfe_4a38_4f2e_8c1a_9c780451c1e6
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: PEMT
is encoded by: hsa:10400

metaR NACHEXA17ly
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000

metaR G14T14g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110041#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110041#

metaM abt e
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01851
has only substance units: false
name: L-arabinitol
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403

metaR GALASE3ly
fast: false
kinetic law: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_a09b7b00_6ebf_4b87_8519_8787376848c2
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:221823
name: PRPS1L1
is: P21108
initial concentration: NaN
initial amount: NaN

metaM galgalgalthcrm hs g
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
is: SBO:0000247
constant: false
is: CHEBI:26174
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_611461a7_3a7f_46d2_a5ea_148ff8a6d619
initial concentration: NaN
boundary condition: true
is: Q96T66
constant: false
name: NMNAT3
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:349565

metaR r0940
name: Free diffusion
fast: false
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ebastine c
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
name: ebastine
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:211060
constant: false
boundary condition: false
is: SBO:0000247

metaM o2s e
is: CHEBI:18421
is: HMDB02168
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide

metaR LNLCCPT2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110041#_4be8c06d_c2c3_4a5c_bc70_6cd3076a50ca
boundary condition: true
has only substance units: false
name: PRDX2
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:7001
initial amount: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM ksi deg2 l
type: Species
boundary condition: false
name: keratan sulfate I, degradation product 2
is: SBO:0000247
is: CHEBI:57312
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01356
constant: false
notes: FORMULA: C241H384N17O210S12 CHARGE: -13

metaR GLUTCOADHm
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: false
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.7
is: SBO:0000176
kinetic law: MODEL1310110041#
name: glutaryl-CoA dehydrogenase (mitochondria)
fast: false
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
reactant: MODEL1310110041#

metaR r2097
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_24797aee_b90d_44db_a7e8_600fcbba1f91
constant: false
is: Q9BZQ4
is encoded by: hsa:23057
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: NMNAT2
is: SBO:0000252

metaR r0202
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR ADK3
name: adentylate kinase (GTP)
is described by: ECO:0000269
modifier: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is: SBO:0000176

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaM dd2coa m
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB03712
is: CHEBI:57330
name: trans-dodec-2-enoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN

metaR r1667
is: SBO:0000185
reactant: MODEL1310110041#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction

metaR r2384
is described by: ECO:0000000
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
reactant: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_b9455c33_65c2_4c07_9d70_30ed9f20c1ca
name: _AI971036_1_c
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:AI971036
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM CE2420 m
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial concentration: 1.0
type: Species
is: HMDB11123
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110041#_a764f3a8_82b7_498a_82fc_437495f85536
is: P50440
is encoded by: hsa:2628
name: GATM
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false

metaR r2309
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_e011d871_6d47_4781_a534_4a8e9ba51c51
type: Species
initial amount: NaN
is: P00326
is encoded by: hsa:126
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ADH1C

metaR r2473
kinetic law: MODEL1310110041#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
reversible: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.4.5
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#

metaM cyan m
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02084
name: hydrogen cyanide
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:18407

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r1668
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
name: Y+LAT2 Utilized transport

metaR r0860
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
name: Utilized transport
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false

metaR r2385
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_51798eaa_e8da_4f5d_a7b2_ada00665d6f7
constant: false
initial concentration: NaN
is encoded by: hsa:79611
boundary condition: true
is: Q9H6R3
type: Species
initial amount: NaN
has only substance units: false
name: ACSS3
is: SBO:0000252

metaM gdpfuc g
initial concentration: 1.0
name: GDP-L-fucose(2-)
is: CHEBI:57984
initial amount: NaN
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
constant: false
boundary condition: false
is: HMDB01095
is: SBO:0000247
type: Species

metaR r1962
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
reversible: false
modifier: MODEL1310110041#

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_5d55dddf_4570_4205_ad64_3ade90758393
name: BDH1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:622
is: Q02338
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM co2 r
initial concentration: 1.0
constant: false
is: C00011
name: CO2
has only substance units: false
type: Species
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
is: HMDB01967
initial amount: NaN
is: SBO:0000247

metaR r1018
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
name: Transport reaction
is described by: ECO:0000000
reversible: true

metaR r0942
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is described by: ECO:0000000

metaM HC01180 c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
type: Species
name: D-tagatofuranose 1,6-bisphosphate(4-)
is: CHEBI:58694
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_07cd3429_5586_4735_9172_7a73706d2fd3
type: Species
has only substance units: false
is: P82251
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:11136
initial amount: NaN
name: SLC7A9
is: SBO:0000252

metaR NACHEX21ly
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110041#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR ARGtiDF
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
type: Reaction
product: MODEL1310110041#
reversible: false
fast: false
is described by: ECO:0000269
name: L-arginine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
reactant: MODEL1310110041#

metaM C05957 r
constant: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
has only substance units: false
name: Prostaglandin J2
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27485
boundary condition: false
is: HMDB02710

http://identifiers.org/biomodels.db/MODEL1310110041#_f919d356_ea2d_48fb_ac20_6f179895b704
boundary condition: true
is encoded by: hsa:226
name: ALDOA
constant: false
type: Species
is: P04075
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR PPPG9tm
is: SBO:0000185
type: Reaction
reversible: true
name: protoporphyrinogen IX mitochondrial transport
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:14623258 NOTES:NCD. Benzodiazepine receptor PBR see also 17168567
product: MODEL1310110041#
fast: false

metaR r2308
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM ksi pre28 g
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00175
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 28
is: C00130
has only substance units: false

metaR ST6GALNAC21
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
is version of: http://identifiers.org/ec-code/2.4.99.7
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_830dbf93_65da_4b4e_81b5_8d6bb87bcecc
has only substance units: false
name: LYZL1
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84569
constant: false
boundary condition: true
is: Q6UWQ5

http://identifiers.org/biomodels.db/MODEL1310110041#_d6560012_3d14_4a48_8c46_2ada536a5e02
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:248
is: SBO:0000252
name: ALPI
constant: false
initial concentration: NaN
initial amount: NaN
is: P09923

metaR RE1532M
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110041#
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_856b480a_ebdf_4187_b866_871c6c653f87
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC16A7
is encoded by: hsa:9194
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q8NEM3

http://identifiers.org/biomodels.db/MODEL1310110041#_fedc3c95_4357_4ee0_92a9_f6d7e8cc7b43
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9Y617
is encoded by: hsa:29968
initial concentration: NaN
constant: false
name: PSAT1
is: SBO:0000252

metaR CH25H
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
fast: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.14.99.38
modifier: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
name: cholesterol 25-hydroxylase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_0ce1f5fb_15c3_4b75_bfdd_3e1e15dadfe7
initial amount: NaN
type: Species
is encoded by: hsa:3177
initial concentration: NaN
constant: false
has only substance units: false
is: Q14542
name: SLC29A2
boundary condition: true
is: SBO:0000252

metaR FRDPtcr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reactant: MODEL1310110041#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
fast: false
type: Reaction
is described by: ECO:0000134
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true

metaR PDE4
product: MODEL1310110041#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.17
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
fast: false
kinetic law: MODEL1310110041#
reversible: false
is described by: ECO:0000269

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_38efc7f2_a102_4d42_9c7f_d9e3971a510f
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: CHST1
boundary condition: true
is: O43916
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8534

metaR r0310
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3

metaR r2386
type: Reaction
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110041#
is described by: ECO:0000000

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: SBO:0000247
is: HMDB00828
is: CHEBI:32814
has only substance units: false
name: N-Carbamoyl-L-aspartate
boundary condition: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00438

metaR ME1m
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
is described by: ECO:0000000
fast: false
name: malic enzyme (NAD), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR r0179
fast: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
product: MODEL1310110041#
reversible: true
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR GLYt2r
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
name: glycine reversible transport via proton symport
type: Reaction
is described by: ECO:0000304

metaM ala B e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16958
name: beta-alanine
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056

metaR r1669
reactant: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR THRGLNexR
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: L-threonine/glycine reversible exchange
product: MODEL1310110041#
is: SBO:0000185
reversible: true

metaR r1019
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110041#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_5d7f947f_73fe_4179_bedd_b2d4957737e9
boundary condition: true
is: Q14432
initial amount: NaN
constant: false
initial concentration: NaN
name: PDE3A
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5139

metaM ksii core4 pre6 g
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C69H111N6O51SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110041#_1336f3bc_e286_4e28_bde2_fd2084b55556
initial amount: NaN
boundary condition: true
is: B7Z6M3
is encoded by: hsa:8525
is: SBO:0000252
has only substance units: false
name: DGKZ
initial concentration: NaN
constant: false
type: Species

metaR PHACCOAGLNAC
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
reversible: false

metaR RE1709C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
product: MODEL1310110041#
name: RE1709
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_8544a863_dc9a_4b8e_9618_68278713876b
has only substance units: false
boundary condition: true
constant: false
name: _AV727634_1_c
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AV727634

metaR CITt4 4
is: SBO:0000185
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000006
kinetic law: MODEL1310110041#
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
type: Reaction
fast: false

metaR S6T14g
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110041#

metaM methf m
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
is: HMDB01354
is: CHEBI:57455
initial concentration: 1.0
boundary condition: false

metaR r0311
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110041#

metaR S23T4g
reactant: MODEL1310110041#
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase
reversible: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_f4435294_e63a_4a45_b7e9_261f8d3b7fb5
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: PDE9A
type: Species
is encoded by: hsa:5152

metaR r0944
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reversible: true
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: Active transport
is: SBO:0000185

metaR r0178
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110041#
reversible: true
fast: false
type: Reaction
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is described by: ECO:0000000
is: SBO:0000176

metaR LALDO2x
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
kinetic law: MODEL1310110041#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
fast: false
type: Reaction

metaM 3otdcoa m
is: CHEBI:28726
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB03935
initial concentration: 1.0
type: Species
name: 3-Oxotetradecanoyl-CoA
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261

http://identifiers.org/biomodels.db/MODEL1310110041#_8f67f339_97e3_4e3b_9256_59f9e031ec7d
constant: false
has only substance units: false
is encoded by: hsa:9154
type: Species
is: Q96PL7
initial concentration: NaN
name: SLC28A1
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM chlstol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
name: 5alpha-cholesta-7,24-dien-3beta-ol
is: HMDB06842
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16290

http://identifiers.org/biomodels.db/MODEL1310110041#_6b097821_afc2_4261_8f97_dfc17d1f67e4
name: AK5
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:26289
type: Species

metaM g3m8masn r
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: C05873
is: SBO:0000247
boundary condition: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR FUT14g
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
product: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.69
reactant: MODEL1310110041#
fast: false
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110041#

metaR NTD1
reversible: false
fast: false
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dUMP)
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110041#

metaM ksii core2 pre6 g
type: Species
boundary condition: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 6
is: CHEBI:28067
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_c0b7097c_5594_4888_a09b_d41b85539ed9
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:343
constant: false
name: AQP8
is: SBO:0000252
is: O94778

metaM pro D e
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB03411
is: CHEBI:16313
name: D-proline
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false

metaM ptrc e
type: Species
name: Putrescine
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01414
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: CHEBI:326268
is: C00134
boundary condition: false

metaR UREAt
name: Urea transport via facilitate diffusion
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110041#
is: SBO:0000185
reversible: true

metaR r2387
modifier: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR DOPABMO
is: SBO:0000176
modifier: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110041#
name: dopamine beta-monooxygenase
reversible: false
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.14.17.1

http://identifiers.org/biomodels.db/MODEL1310110041#_2ef5820e_c4e3_42bc_bd96_e0e230ec76ae
name: EPX
is: P11678
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:8288
initial amount: NaN
constant: false
initial concentration: NaN

metaR PHEt4
product: MODEL1310110041#
type: Reaction
reversible: false
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-phenylalanine transport in via sodium symport
reactant: MODEL1310110041#

metaR FAOXC204
type: Reaction
reversible: false
name: Beta oxidation of long chain fatty acid
product: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR AMETtd
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
name: diffusion of S-Adenosyl-L-methionine
fast: false
is described by: ECO:0000134
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110041#

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR F6Tg
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
name: glycoprotein 6-alpha-L-fucosyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_4b053693_cf28_410d_b852_64778cf11668
is encoded by: hsa:9498
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: E7EML0
has only substance units: false
name: SLC4A8

metaR r1830
reactant: MODEL1310110041#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#
reversible: false
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_95152f6b_2cbb_4b33_9198_82be8251ce8b
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: FOLR3
is: Q05C14
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:2352

metaM cbasp e
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: SBO:0000247
is: CHEBI:32814
is: HMDB00828
type: Species
name: N-Carbamoyl-L-aspartate
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: C00438

metaR OCDCAtr
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_a81c7357_e937_4ef1_8e3f_3138adce087f
is: P14854
initial amount: NaN
is encoded by: hsa:1340
name: COX6B1
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_c6d4e98b_6419_4301_b220_ece4bb1aa7e2
initial amount: NaN
name: COX4I2
is: SBO:0000252
is: Q96KJ9
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:84701

metaR LNLNCAt
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185

metaR r2388
reactant: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR ACOAD10m
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110041#

metaR H2Oter
product: MODEL1310110041#
name: H2O endoplasmic reticulum transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM arachcoa m
constant: false
is: CHEBI:15527
initial amount: NaN
has only substance units: false
is: HMDB04258
type: Species
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0
is: SBO:0000247
name: arachidyl coenzyme A

metaR H2O2tn
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185
reactant: MODEL1310110041#
name: hydrogen peroxide nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it

metaM nadp m
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00006
constant: false

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_7d1afd7e_b394_4e53_ab73_389d131e1077
type: Species
constant: false
is encoded by: hsa:223
initial amount: NaN
boundary condition: true
has only substance units: false
is: P49189
is: SBO:0000252
name: ALDH9A1
initial concentration: NaN

metaM ru5p D r
is: HMDB00618
is: CHEBI:58121
name: D-ribulose 5-phosphate(2-)
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species

metaM cmp m
boundary condition: false
constant: false
type: Species
has only substance units: false
name: CMP(2-)
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
initial concentration: 1.0
is: CHEBI:60377
initial amount: NaN

metaM co2 m
boundary condition: false
constant: false
type: Species
is: CHEBI:16526
has only substance units: false
is: C00011
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: HMDB01967
name: CO2

metaR MMSAD1m
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
product: MODEL1310110041#

metaM dgtp n
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01440
name: dGTP
is: CHEBI:16497
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
is: SBO:0000247
is: C00286

http://identifiers.org/biomodels.db/MODEL1310110041#_b7ba062a_3c57_4c01_8abe_a21f74a627e2
is: SBO:0000252
initial amount: NaN
is: Q92911
constant: false
type: Species
boundary condition: true
is encoded by: hsa:6528
initial concentration: NaN
name: SLC5A5
has only substance units: false

metaM leuktrE4 c
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
constant: false
is: HMDB02200
has only substance units: false
is: SBO:0000247
is: CHEBI:57462
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaR AG13T17g
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110041#

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: dTDP
is: HMDB01274
is: CHEBI:58369
is: C00363
initial amount: NaN
is: SBO:0000247
type: Species

metaR CYTDK2m
name: cytidine kinase (ATP), mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false

metaR r0946
reversible: true
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR RE3218C
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
product: MODEL1310110041#
reversible: true
type: Reaction
reactant: MODEL1310110041#
name: RE3218
is: SBO:0000176

metaR UPP3S
name: uroporphyrinogen-III synthase
kinetic law: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.75
reactant: MODEL1310110041#
reversible: false

metaR r1664
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
fast: false
reversible: true
kinetic law: MODEL1310110041#

metaR GLNtN1
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Glutamine transport (Na, H coupled)
product: MODEL1310110041#
fast: false
type: Reaction

metaR r2389
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
is: SBO:0000185
modifier: MODEL1310110041#

metaR B3GNT34g
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110041#

metaM tym c
is: CHEBI:327995
initial concentration: 1.0
boundary condition: false
name: tyraminium
has only substance units: false
is: HMDB00306
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483

http://identifiers.org/biomodels.db/MODEL1310110041#_4afe2394_2955_4628_9c3f_997ee4fd117b
type: Species
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:56922
name: MCCC1:MCCC2
initial amount: NaN
boundary condition: true
is encoded by: hsa:64087
has part: Q9HCC0
has only substance units: false
has part: Q96RQ3
constant: false

metaM oxa m
constant: false
name: oxalate(2-)
is: SBO:0000247
has only substance units: false
is: HMDB02329
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
initial amount: NaN
type: Species
boundary condition: false

metaR PHEACGLNt
name: PHEACGLN extracellular transport via diffusion
product: MODEL1310110041#
type: Reaction
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000
is: SBO:0000185

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaM bamppald c
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
initial amount: NaN
initial concentration: 1.0
is: HMDB01106
type: Species
is: http://identifiers.org/pubchem.compound/7975
name: beta-Aminopropion aldehyde
is: C05665
is: SBO:0000247

metaM cmp n
constant: false
name: CMP(2-)
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00095
is: CHEBI:60377
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_672185a9_8e43_4885_9d87_bb54eba9c9dc
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8613
is: SBO:0000252
name: PPAP2B
boundary condition: true
is: O14495
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_11277dc1_4a2d_497c_b5c9_07997dcdfbfc
is: SBO:0000252
initial concentration: NaN
name: ENTPD8
has only substance units: false
initial amount: NaN
is encoded by: hsa:377841
boundary condition: true
constant: false
is: Q5MY95
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_10680587_2d45_487b_849d_786f1fc358fa
is: Q10472
is encoded by: hsa:2589
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: GALNT1

metaR TCYNTt
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
reactant: MODEL1310110041#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
kinetic law: MODEL1310110041#
reversible: false
fast: false

metaR r1665
product: MODEL1310110041#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_818cc992_d83d_49f9_9e35_4be8e7b3779a
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:85365
name: ALG2
initial concentration: NaN
type: Species
boundary condition: true

metaR DSAT
reversible: false
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#
name: dihydrosphingosine N-acyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

http://identifiers.org/biomodels.db/MODEL1310110041#_93fa940b_be2f_498d_801a_3411a6a399ad
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80308
boundary condition: true
name: FLAD1
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM ncam c
has only substance units: false
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:0
is: HMDB01406
type: Species
initial concentration: 1.0
initial amount: NaN
is: C00153

metaR FAS160COA
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110041#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
product: MODEL1310110041#

metaM sphs1p r
is: SBO:0000247
is: CHEBI:60119
initial amount: NaN
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00277
name: sphingosine 1-phosphate(1-)

metaM leuktrE4 e
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB02200
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
is: CHEBI:57462
has only substance units: false
initial amount: NaN
type: Species

metaR PALFATPtc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_0953d649_b089_40d1_a24d_5a89c23826b8
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:2523
has only substance units: false
is: Q6IZA2
name: FUT1

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM malthx e
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
has only substance units: false
constant: false
is: C01936
initial amount: NaN

metaR r1666
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110041#_3601a684_fc55_49b0_8e7d_988ce4461b91
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:7086
has only substance units: false
is: E7EPA7
name: TKT
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_277e9131_b240_4ef5_aa56_a82ab0210807
initial amount: NaN
has only substance units: false
name: PTDSS1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9791
type: Species
is: SBO:0000252
is: P48651
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6131c439_62ab_402e_9c80_a4c04196ddb9
is: Q53H96
is encoded by: hsa:65263
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PYCRL
boundary condition: true
type: Species

metaM glc D r
constant: false
is: HMDB00122
has only substance units: false
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
name: D-glucose
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR CDIPTr
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.8.11
product: MODEL1310110041#
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
name: phosphatidylinositol synthase (Homo sapiens)
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_dbacdf1e_086e_4dfc_b3fb_62cc3d9d188d
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: P48067
is encoded by: hsa:6536
name: SLC6A9
is: SBO:0000252
initial amount: NaN

metaM o2s m
name: Superoxide anion
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:18421
constant: false
has only substance units: false

metaR CEPTC
is: SBO:0000176
modifier: MODEL1310110041#
name: choline phosphotransferase
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.2
product: MODEL1310110041#
type: Reaction

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR GTHOm
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
is described by: ECO:0000254
name: glutathione oxidoreductase
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR CGLYt3 2
name: Cys-Gly transport in via proton symport
fast: false
is described by: ECO:0000304
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
type: Reaction

metaR B3GNT33g
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110041#
reversible: false
type: Reaction
modifier: MODEL1310110041#

metaR r0081
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
reversible: true
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
type: Reaction
reactant: MODEL1310110041#

metaR r1561
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR DURIt
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reactant: MODEL1310110041#
name: deoxyuridine transport via diffusion
fast: false
product: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_1be7d4f7_ee29_429b_84ab_f38b22040ec3
has only substance units: false
is: P47895
boundary condition: true
is encoded by: hsa:220
initial amount: NaN
initial concentration: NaN
name: ALDH1A3
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_15df5a82_195d_42bd_b18d_3cf07cd60a49
is encoded by: hsa:AL038231
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AL038231_1_c
initial amount: NaN
constant: false

metaM utp e
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: CHEBI:46398
is: SBO:0000247
has only substance units: false
is: HMDB00285
initial amount: NaN
initial concentration: 1.0
name: UTP(4-)
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_95b20989_db5f_4f21_9571_601823cf43bd
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA502753
boundary condition: true
constant: false
initial amount: NaN
name: _AA502753_1_m
has only substance units: false

metaR TRPt
reversible: true
name: L-tryptophan transport
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110041#
fast: false
is: SBO:0000185
type: Reaction

metaR r1605
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_e550bb29_225c_489b_83f4_0c66b2e6667f
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: Q9BY07
name: SLC4A5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:57835
initial amount: NaN

metaR RE2660C
is: SBO:0000176
reversible: true
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
reactant: MODEL1310110041#
name: RE2660
kinetic law: MODEL1310110041#
type: Reaction

metaM ksi deg33 l
boundary condition: false
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate I, degradation product 33
type: Species
initial amount: NaN
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ddb6743b_2852_4791_a9b1_fb23618481ae
is: Q308M7
initial concentration: NaN
type: Species
is encoded by: hsa:5169
name: ENPP3
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_af7ba2cb_ccdc_443c_87be_40eeb27ab63b
name: DPM3:DPM1:DPM2
initial concentration: NaN
is encoded by: hsa:54344
is encoded by: hsa:8818
is: SBO:0000297
has part: Q9P2X0
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_10e98cba_5fec_4220_ac61_50222b57e6a0
is: B4DIA3
name: SLC6A8
is encoded by: hsa:6535
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR CHOLATEt
is described by: ECO:0000269
reversible: true
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ffd74129_cf70_4042_93b9_7724ba1712fc
type: Species
is encoded by: hsa:54344
constant: false
is: Q86TM7
initial amount: NaN
name: DPM3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaR LEUTAm
is described by: ECO:0000269
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
name: leucine transaminase, mitochondrial

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR r1560
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185

metaM dhdascb c
has only substance units: false
boundary condition: false
is: CHEBI:58070
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: dehydroascorbide(1-)
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: HMDB01264
is: SBO:0000247

metaR H2O2tp
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
name: hydrogen peroxide peroxisomal transport via diffusion
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110041#
type: Reaction

metaR NH4t3r
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
name: ammonia transport via proton antiport
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:

metaR FATP1t
fast: false
reversible: true
modifier: MODEL1310110041#
name: fatty acid electroneutral transport
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
product: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

metaR r1606
fast: false
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DOLPH Uer
reactant: MODEL1310110041#
is: SBO:0000176
name: Dolichol-phosphate phosphohydrolase, human (uterus)
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is described by: ECO:0000000
product: MODEL1310110041#
fast: false
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6d5f0310_ef77_4e00_84e7_2fc8f1472ada
initial concentration: NaN
type: Species
constant: false
has part: Q15102
initial amount: NaN
has part: A8DPS7
is: SBO:0000297
name: PAFAH1B2:PAFAH1B3
has only substance units: false
is encoded by: hsa:5050
is encoded by: hsa:5049
boundary condition: true

metaR r0724
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
product: MODEL1310110041#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_b4cbb7d5_ecb0_463e_87f7_f90e6bc7c0fc
initial concentration: NaN
initial amount: NaN
name: H6PD
boundary condition: true
is: SBO:0000252
is: O95479
has only substance units: false
type: Species
constant: false
is encoded by: hsa:9563

metaM pmtcoa m
boundary condition: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:57379
is: HMDB01338
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_f3c26801_6e56_488d_a5d5_da9a2eff7dda
is encoded by: hsa:4695
initial concentration: NaN
has only substance units: false
name: NDUFA2
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: O43678
boundary condition: true

metaR r0196
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
kinetic law: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_07aba4e6_4937_4179_8c57_14e05e006c21
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8706
constant: false
is: Q49AT3
boundary condition: true
name: B3GALNT1
is: SBO:0000252

metaR H2CO3D
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
is described by: ECO:0000000
fast: false
name: carboxylic acid dissociation
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.1
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_9afa9dd4_d812_47b2_aeb5_5b9a1b969529
initial amount: NaN
boundary condition: true
type: Species
has part: O15270
has part: O15269
is: SBO:0000297
name: SPTLC1:SPTLC2
is encoded by: hsa:9517
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10558
constant: false

metaR r0083
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110041#
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110041#
reversible: true

metaM acglcgalgbside hs g
constant: false
initial concentration: 1.0
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:26174
name: GlcNAc-Gal globoside

metaM xan c
is: HMDB00292
name: Xanthine
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
is: C00385
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a457fa63_cf37_4081_adc4_895acb362c23
type: Species
is: E9PCP2
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: CPT1B
is encoded by: hsa:1375

metaR r1010
name: Postulated transport reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction

metaR BDMT U
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.142
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110041#
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction

metaR BACCLm
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.3.4.10
product: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is described by: ECO:0000254
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reversible: false

metaR NACHEXA21ly
fast: false
is described by: ECO:0000000
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_7ef975e0_20c5_47cc_aee4_1a154323fdcb
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:8608
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is: O75452
name: RDH16

metaR LPS3e
type: Reaction
reversible: false
name: lipase, extracellular
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
product: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaM man l
type: Species
constant: false
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
is: SBO:0000247
is: CHEBI:16024
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00169

http://identifiers.org/biomodels.db/MODEL1310110041#_f7e8206e_23e7_4e78_934e_c4b1302ead03
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: PDE9A
initial amount: NaN
boundary condition: true
is encoded by: hsa:5152
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f6222179_27f8_4549_afa7_37d5ddaa7f64
has only substance units: false
initial amount: NaN
is encoded by: hsa:5335
initial concentration: NaN
name: PLCG1
type: Species
is: Q9UFY1
is: SBO:0000252
constant: false
boundary condition: true

metaR r1603
is described by: ECO:0000000
reactant: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaM utp c
is: SBO:0000247
is: CHEBI:46398
name: UTP
initial concentration: 1.0
is: C00075
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: HMDB00285

metaM 4ppcys m
is: CHEBI:59458
is: HMDB01117
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species

metaR RE3626M
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
name: RE3626
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM ppbng c
constant: false
is: SBO:0000247
name: Porphobilinogen
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00931
is: CHEBI:58126
initial amount: NaN
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
type: Species
is: HMDB00245

metaR r0926
name: Postulated transport reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaR SIAASE4ly
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal

metaM prostge2 c
constant: false
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false
type: Species
is: HMDB01220
boundary condition: false
name: prostaglandin E2(1-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM pmtcrn r
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
name: L-palmitoylcarnitine
boundary condition: false
is: HMDB00222
constant: false
is: CHEBI:17490
initial concentration: 1.0

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM fum m
is: CHEBI:29806
initial amount: NaN
boundary condition: false
is: C00122
constant: false
has only substance units: false
is: HMDB00134
initial concentration: 1.0
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_67f7e488_64ab_4d58_bcd7_40c0ce2a0bad
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI926493
name: _AI926493_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_a56605e8_8068_4e60_8dd3_fd1b5faaf7cc
is: SBO:0000252
name: GSTZ1
is encoded by: hsa:2954
type: Species
initial amount: NaN
is: O43708
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_18702c18_7af8_43f0_a67c_1289e8204d50
type: Species
is encoded by: hsa:2936
constant: false
has only substance units: false
initial concentration: NaN
is: P00390
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: GSR

metaM ncam e
name: Nicotinamide
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
boundary condition: false
has only substance units: false
is: CHEBI:0
is: HMDB01406
initial concentration: 1.0

metaM mercppyr c
is: CHEBI:57678
name: 3-mercaptopyruvate
is: HMDB01368
type: Species
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_cc11a628_9914_4dde_9c8e_9696ab5c539a
constant: false
name: ACOT6
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: Q3I5F7
initial concentration: NaN
is encoded by: hsa:641372
is: SBO:0000252

metaR r0726
is: SBO:0000176
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
fast: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR B3GNT313g
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110041#
is described by: ECO:0000254
product: MODEL1310110041#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
fast: false

metaM acald e
is: HMDB00990
boundary condition: false
name: acetaldehyde
has only substance units: false
is: SBO:0000247
is: CHEBI:15343
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaR r1604
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185

metaR r0879
product: MODEL1310110041#
is: SBO:0000185
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1

http://identifiers.org/biomodels.db/MODEL1310110041#_40103b27_d8e1_4c46_8129_39b6a59a1a11
is encoded by: hsa:200010
initial concentration: NaN
initial amount: NaN
name: SLC5A9
is: SBO:0000252
has only substance units: false
is: E9PAK4
type: Species
boundary condition: true
constant: false

metaM apoC Lys btn c
initial amount: NaN
has only substance units: false
boundary condition: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: CHEBI:32551
is: SBO:0000247
is: HMDB00182
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_927484cd_e727_45e6_bb19_3180405a52f3
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:146712
initial amount: NaN
has only substance units: false
is: Q67FW5
boundary condition: true
is: SBO:0000252
name: B3GNTL1

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM HC02121 c
is: SBO:0000247
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
constant: false
is: CHEBI:58758
type: Species
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM thbpt4acam n
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374

metaM malttr e
has only substance units: false
is: HMDB01262
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial amount: NaN
is: C01835
type: Species
name: maltotriose
boundary condition: false
is: CHEBI:27931

http://identifiers.org/biomodels.db/MODEL1310110041#_a57d132b_be5a_455a_acd5_d685a4e7b755
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: O95139
is encoded by: hsa:4712
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFB6

metaR S6T5g
product: MODEL1310110041#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR UGALNACtg
is described by: ECO:0000269
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
reversible: true
name: UDP-GalNAc Golgi transport via CMP antiport
is: SBO:0000185

metaR PETOHMm hs
is described by: ECO:0000254
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reversible: false
name: phosphatidylethanolamine N-methyltransferase
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.1.1.17

http://identifiers.org/biomodels.db/MODEL1310110041#_d7270d97_131f_49ea_b459_944c9f5d6c23
boundary condition: true
initial amount: NaN
is: Q6IBC4
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4726
name: NDUFS6

http://identifiers.org/biomodels.db/MODEL1310110041#_1e4bbb4d_afd5_40a7_a76e_d9edb07f54ab
initial concentration: NaN
is encoded by: hsa:5052
name: PRDX1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: Q06830
has only substance units: false
type: Species

metaR CYTDt
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
type: Reaction
name: cytidine facilated transport in cytosol
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaM mlthf c
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: HMDB01533
has only substance units: false
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636

metaM glutcoa m
initial amount: NaN
has only substance units: false
is: HMDB01339
name: glutaryl-CoA(5-)
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57378
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_8a14f078_9fe8_4a06_8d6f_169b43de84f8
initial amount: NaN
type: Species
is encoded by: hsa:594
constant: false
has only substance units: false
boundary condition: true
name: BCKDHB
is: SBO:0000252
is: P21953
initial concentration: NaN

metaR r1565
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_997b6b0d_1dc4_4c71_b369_40d784dd6dd9
name: PDE9A
is encoded by: hsa:5152
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR GLNyLATthc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_819e065a_df1d_4686_aded_392798232ba1
constant: false
initial concentration: NaN
has only substance units: false
is: Q9Y233
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PDE10A
is encoded by: hsa:10846
type: Species

metaM pmtcoa r
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:3454
boundary condition: false
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110041#_6936a4d4_fd0d_458a_b659_ebc6e3dea181
is: SBO:0000252
is encoded by: hsa:5332
boundary condition: true
initial amount: NaN
is: E2QRH8
initial concentration: NaN
has only substance units: false
type: Species
name: PLCB4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4703815d_fcf2_49ac_988e_af7976e6e092
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ACADM
is: P11310
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110041#_25e65895_0a6b_47a2_88ee_31e90695d360
type: Species
is encoded by: hsa:314
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: AOC2

metaR r0504
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_6c969ca8_58f6_4f04_8312_38415b343045
name: DPAGT1
is encoded by: hsa:1798
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: Q9H3H5
constant: false

metaM dolp U c
name: dolichyl phosphate(2-)
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:57683
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
initial concentration: 1.0

metaR r1564
type: Reaction
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM rbt c
is: HMDB00508
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
type: Species
name: D-ribitol
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:15963
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_0404c26d_0c6b_4994_aea0_757d88b9d8b9
is: Q9NSC7
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55808
name: ST6GALNAC1
initial amount: NaN

metaR r1602
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r1459
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
name: Transport reaction

metaR THMP
is: SBO:0000176
name: thiamin phosphatase
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reactant: MODEL1310110041#
reversible: false
product: MODEL1310110041#

metaM gsn c
is: CHEBI:16750
name: Guanosine
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00133
initial concentration: 1.0
has only substance units: false
is: C00387

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR FUT99g
fast: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.152
reversible: false
name: Alpha-(1,3)-fucosyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#

metaM g2m8masn r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: C05874
has only substance units: false
initial amount: NaN
notes: FORMULA: C82H137N2O65X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaR r0728
is: SBO:0000176
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6444fea7_7597_4643_b684_6f59aaff82a1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI222095
initial concentration: NaN
boundary condition: true
type: Species
name: _AI222095_1_m
constant: false
has only substance units: false

metaR CLFORtex
type: Reaction
reversible: false
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: chloride transport via formate countertransport
modifier: MODEL1310110041#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110041#_bccd506a_a054_48af_a5c5_520761f959a0
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLC23A1
is: SBO:0000252
is encoded by: hsa:9963
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_ff609919_b94d_4bd6_82f6_7a82071b01cf
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3158
constant: false
has only substance units: false
name: HMGCS2
type: Species
is: P54868
initial amount: NaN

metaR ADSL1
reversible: false
modifier: MODEL1310110041#
fast: false
name: adenylosuccinate lyase
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.3.2.2
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is described by: ECO:0000269

metaR 2OXOADPTm
name: 2-oxoadipate shuttle (cytosol/mitochondria)
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reactant: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_74e1cac3_2f22_41b8_9bcc_d364a91eec95
is encoded by: hsa:AI653169
constant: false
name: _AI653169_1_c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR B3GNT11g
fast: false
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is: SBO:0000176
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reversible: false
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaM ethamp r
is: HMDB00224
initial amount: NaN
has only substance units: false
name: O-phosphonatoethanaminium(1-)
initial concentration: 1.0
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_61d9fd87_ba02_471a_a5a9_c1c4201294ff
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: UCKL1
initial amount: NaN
is encoded by: hsa:54963
is: Q53HM1

http://identifiers.org/biomodels.db/MODEL1310110041#_9809d9de_3b9a_4203_a919_4a262ad2d472
is: Q8IZH9
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2643
name: GCH1
constant: false
boundary condition: true

metaM HC01409 m
name: Hexanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:27540

http://identifiers.org/biomodels.db/MODEL1310110041#_5292a05e_ad8b_44ef_9435_8e3d556f25e6
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
is: D3DX95
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r0502
reversible: true
reactant: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.113
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110041#
fast: false

metaR r1563
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_e3336dd1_3f57_433a_a52d_7e2c0b310a59
has part: B4E3E9
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:4967
name: DLD:DLST:OGDH:PDHX
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaR PGLYCt
name: phosphatidylglycerol transport
is described by: ECO:0000269
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
product: MODEL1310110041#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_f580255f_0688_4d0e_be7a_121ff21dcd06
is encoded by: hsa:10246
is: SBO:0000252
boundary condition: true
type: Species
name: SLC17A2
initial concentration: NaN
has only substance units: false
is: O00624
constant: false
initial amount: NaN

metaM pan4p m
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: pantetheine 4'-phosphate(2-)
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: SBO:0000247
is: CHEBI:47942
has only substance units: false
is: HMDB01416

metaR ADSL2
is described by: ECO:0000269
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
kinetic law: MODEL1310110041#
name: adenylosuccinate lyase
reversible: false
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110041#

metaM ksi pre19 g
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 19
is: C00130
boundary condition: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
type: Species
constant: false
is: HMDB00175
initial amount: NaN
is: SBO:0000247
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110041#_58e81bff_936f_4e75_b33f_65b8f5f14f8a
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: HAGH
is: Q16775
initial amount: NaN
boundary condition: true
is encoded by: hsa:3029

http://identifiers.org/biomodels.db/MODEL1310110041#_f1603b09_ae50_49ec_810d_0f32e284af8d
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110041#_477e7435_6845_41a8_b8e6_cc5bbf9ad215
name: _AI291895_1_c
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI291895
type: Species
initial amount: NaN

metaR r1600
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true

metaM rbt e
type: Species
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: SBO:0000247
name: D-ribitol
constant: false
boundary condition: false
is: HMDB00508
is: CHEBI:15963
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_7914f7b8_3830_44f5_aecc_ad4f92759977
is: SBO:0000252
type: Species
initial amount: NaN
name: ALDH3B2
has only substance units: false
constant: false
is: P48448
initial concentration: NaN
is encoded by: hsa:222
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_a4fb86a4_d117_4eb9_a171_1a17095788fb
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:8659
name: ALDH4A1
initial concentration: NaN

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#

metaM n2m2mn l
notes: FORMULA: C42H71N3O31 CHARGE: 0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
initial concentration: 1.0
is: CHEBI:16680
is: HMDB00939
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaM ethamp c
initial amount: NaN
constant: false
name: ethamp[c]
has only substance units: false
is: SBO:0000247
is: HMDB00224
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110041#_ca084ca7_0ff8_4102_91f5_2f9ba1659474
name: DOLPP1
is: SBO:0000252
is encoded by: hsa:57171
is: Q86YN1
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaM prostgf2 e
initial concentration: 1.0
is: HMDB01139
is: CHEBI:57404
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
initial amount: NaN
name: prostaglandin F2alpha(1-)

metaR ALAR
type: Reaction
fast: false
name: alanine racemase
is described by: ECO:0000212
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110041#
reversible: true

metaR r2506
name: Utilized transport
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_69a2e1f6_61f3_4a82_800b_4bb72ccd9001
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: SLC2A11
is encoded by: hsa:66035
constant: false
boundary condition: true
is: Q8WXF9

metaM peamn c
constant: false
name: 2-phenylethanaminium
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:225237
is: HMDB12275
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial amount: NaN

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR r1569
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_59d740fc_8f49_497f_9964_3192dca80a46
type: Species
boundary condition: true
is encoded by: hsa:116369
name: SLC26A8
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_50294817_222a_481a_b372_6beef9067883
has only substance units: false
name: _AI769281_1_e
is: SBO:0000252
is encoded by: hsa:AI769281
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaR FUMtm
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#
fast: false
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV

metaR CYTK13n
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110041#
is described by: ECO:0000269
type: Reaction

metaM msa m
is: CHEBI:33190
initial concentration: 1.0
type: Species
is: HMDB11111
is: SBO:0000247
name: 3-oxopropanoate
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222

metaR r0509
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
product: MODEL1310110041#

metaM fmn c
name: FMN
has only substance units: false
is: HMDB01520
initial concentration: 1.0
is: C00061
is: CHEBI:58210
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: SBO:0000247

metaR MG3er
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM HC00900 c
is: CHEBI:30860
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial amount: NaN
name: Methylmalonate
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9505be30_8d92_42ff_b9e5_84b56438bbae
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _H17063_1_m
constant: false
has only substance units: false
is encoded by: hsa:H17063
initial concentration: NaN

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000
reversible: true
name: RE3524
reactant: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
fast: false

metaR r2507
name: Utilized transport
reversible: true
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_e8363c6c_9569_464a_80a6_a1a8a0535e61
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5091
type: Species
is: P11498
initial amount: NaN
name: PC
initial concentration: NaN
is: SBO:0000252

metaR r1568
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110041#
type: Reaction

metaM fuc1p L c
name: L-Fucose 1-phosphate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
boundary condition: false
is: CHEBI:28319
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01265
constant: false

metaR CYTK3n
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM ksii core2 pre8 g
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
type: Species
constant: false
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
is: CHEBI:58053
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110041#_ab318efe_3a71_4824_b608_d580c6c001be
is: Q9P019
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:29085
initial amount: NaN
is: SBO:0000252
type: Species
name: PHPT1
boundary condition: true

metaR r2027
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000000
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

metaM utp n
is: SBO:0000247
type: Species
is: HMDB00285
constant: false
initial concentration: 1.0
is: CHEBI:46398
has only substance units: false
boundary condition: false
name: UTP(4-)
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaR AIRCr
is version of: http://identifiers.org/ec-code/6.3.2.6
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
type: Reaction
name: phosphoribosylaminoimidazole carboxylase
modifier: MODEL1310110041#

metaM 4abut m
boundary condition: false
type: Species
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: SBO:0000247
is: CHEBI:16865
initial concentration: 1.0
is: HMDB00112
has only substance units: false
constant: false
initial amount: NaN
is: C00334

http://identifiers.org/biomodels.db/MODEL1310110041#_24fed7b9_65a4_4fde_90c6_0ace4e7fd50d
constant: false
is: Q5JWV8
type: Species
name: ACSL4
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2182
initial amount: NaN
is: SBO:0000252

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM pmtcoa x
has only substance units: false
initial amount: NaN
is: CHEBI:57379
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
is: C00154
constant: false
type: Species
initial concentration: 1.0
is: HMDB01338
boundary condition: false

metaM thbpt4acam c
constant: false
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
is: CHEBI:15374
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
type: Species
is: HMDB02281

metaR RE0935E
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0935
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_41f57205_bf40_4367_965b_6e87d52f3fa1
initial amount: NaN
name: _AA278423_1_m
is encoded by: hsa:AA278423
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaM man c
is: CHEBI:16024
is: HMDB00169
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: D-Mannose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159

metaR r1567
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_bfd70723_0b67_4444_8ce8_f9f1cc38cbed
is: P06132
boundary condition: true
initial concentration: NaN
name: UROD
type: Species
constant: false
is encoded by: hsa:7389
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR G14T3g
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
product: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176

metaR r2508
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction

metaR r2026
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_93d5c9d0_c276_4a44_90a2_49a51688b071
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4023
boundary condition: true
name: LPL
is: P06858

metaR r0591
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reversible: true
modifier: MODEL1310110041#
is: SBO:0000176
fast: false
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_74c58e31_5bf2_42df_b68f_f4c52a21e617
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:55753
name: OGDHL
type: Species
initial concentration: NaN
boundary condition: true
is: Q9ULD0
initial amount: NaN

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110041#
is described by: ECO:0000269
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110041#
reversible: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
is: SBO:0000176

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_69e11f9d_1a95_4024_ab12_b5ad7d454546
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2936
is: SBO:0000252
is: P00390
constant: false
name: GSR
initial concentration: NaN
has only substance units: false

metaM dolp U r
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57683
initial amount: NaN
initial concentration: 1.0
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

http://identifiers.org/biomodels.db/MODEL1310110041#_5c0e87dc_751f_4fee_a3f1_79cca3e7de56
boundary condition: true
type: Species
name: MTMR2
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:8898
initial amount: NaN
is: A6NN98
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5dea8b9b_4699_4738_9850_6c9967110782
constant: false
type: Species
name: _AD000092_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AD000092
has only substance units: false

metaR r1566
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000185

metaM HC00342 c
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
is: CHEBI:16383
name: cis-aconitate(3-)
initial concentration: 1.0
has only substance units: false

metaR PHCHGSm
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
type: Reaction
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reactant: MODEL1310110041#

metaR r1453
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reversible: true
type: Reaction
fast: false
product: MODEL1310110041#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: NODe
fast: false
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000134

metaR RDH3a
is described by: ECO:0000269
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
type: Reaction
reversible: true
name: retinol dehydrogenase (11-cis,NADPH)
modifier: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT

metaR MECOALm
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000212
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.5
name: mesaconate--CoA ligase (ADP-forming), mitochondrial

metaR r0590
kinetic law: MODEL1310110041#
is: SBO:0000176
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110041#
modifier: MODEL1310110041#

metaR DASCBR
reversible: false
modifier: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
name: dehydroascorbate reductase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.4.1
reactant: MODEL1310110041#

metaM 2mbcoa m
initial amount: NaN
is: HMDB01041
boundary condition: false
is: CHEBI:57336
has only substance units: false
type: Species
name: 2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_e2f17cef_3a9a_4501_9c21_1999f0f1e342
initial concentration: NaN
is encoded by: hsa:4694
initial amount: NaN
type: Species
name: NDUFA1
boundary condition: true
is: Q6IBB5
is: SBO:0000252
has only substance units: false
constant: false

metaM CE1926 e
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
initial amount: NaN
type: Species
is: HMDB00127
constant: false
is: CHEBI:15748
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926

metaR G6PDH2rer
reversible: true
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
fast: false
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
product: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction

metaR CMPACNAtg
product: MODEL1310110041#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: CMP-Sia Golgi transport via CMP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
fast: false
modifier: MODEL1310110041#

metaR D3AIBTm
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
type: Reaction
is: SBO:0000176
reversible: true

metaR r1609
fast: false
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#

metaM pmtcrn c
has only substance units: false
initial concentration: 1.0
is: HMDB00222
type: Species
is: CHEBI:17490
is: SBO:0000247
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
constant: false
boundary condition: false

metaR RE0567C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: RE0567
product: MODEL1310110041#
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_6a87f26b_d22a_42d0_b5c6_ef1b92418b0e
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: RPIA
is: P49247
is encoded by: hsa:22934

metaM glu L m
is: HMDB00148
constant: false
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:29985
is: SBO:0000247
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110041#_3b79d0f9_3728_4e77_8739_51496be9579a
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7352
initial amount: NaN
type: Species
boundary condition: true
name: UCP3

metaR PMTCOAtx
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110041#
name: fatty acid intracellular transport
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110041#_4e8db7c9_1e33_4ef7_9166_2505a404a192
boundary condition: true
is: Q16718
name: NDUFA5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4698
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaM dkmpp c
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 2,3-diketo-5-methylthio-1-phosphopentane
is: CHEBI:58828
notes: FORMULA: C6H9O6PS CHARGE: -2
is: SBO:0000247
has only substance units: false
is: C15650

http://identifiers.org/biomodels.db/MODEL1310110041#_74a4df71_e9ca_45fa_a0f9_040131b3f8bf
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: B7Z6Q4
name: IMPA1
initial amount: NaN
is encoded by: hsa:3612

metaR r0085
fast: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110041#
is: SBO:0000176
type: Reaction
reversible: false

metaR APRGSTRNte
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: hydroxyprogesterone transport
reversible: true
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_8f6d3f4d_d6b8_43ab_8d33_3a291ef70613
boundary condition: true
constant: false
is encoded by: hsa:5244
name: ABCB4
is: SBO:0000252
is: A4D1D5
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaM fpram c
boundary condition: false
initial concentration: 1.0
is: CHEBI:58478
type: Species
is: HMDB06211
is: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM prostge2 e
has only substance units: false
type: Species
is: HMDB01220
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial concentration: 1.0
name: prostaglandin E2(1-)
constant: false
boundary condition: false
is: SBO:0000247

metaR r2024
reactant: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM HC02179 e
type: Species
initial amount: NaN
is: CHEBI:34306
boundary condition: false
name: 20-hydroxy-arachidonate
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

http://identifiers.org/biomodels.db/MODEL1310110041#_a59a7428_c268_4767_b679_6a8559b47c4a
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ST20
type: Species
is: Q9HBF5
constant: false
is encoded by: hsa:400410

metaR r0720
reactant: MODEL1310110041#
fast: false
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR r0443
modifier: MODEL1310110041#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
reversible: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_bc118c65_4dea_46bc_b1d1_4a268f2ff197
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: RDH8
is: Q9NYR8
is encoded by: hsa:50700
type: Species
has only substance units: false

metaR r0596
fast: false
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
product: MODEL1310110041#
type: Reaction
is: SBO:0000176

metaM acald c
has only substance units: false
is: HMDB00990
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15343
initial amount: NaN
is: SBO:0000247
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaM man6p c
is: CHEBI:17369
initial amount: NaN
name: D-Mannose 6-phosphate
has only substance units: false
boundary condition: false
is: HMDB01078
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
initial concentration: 1.0
type: Species
constant: false

metaR TMDPK
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.2
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176

metaR RE3003M
name: RE3003
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110041#

metaR DOLPGT2 Uer
is: SBO:0000176
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.265
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_774eba2d_8cad_45e3_8be4_56c2315959c1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: DGKE
initial amount: NaN
type: Species
is encoded by: hsa:8526
is: A1L4Q0

metaR DNDPt36m
modifier: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110041#
is described by: ECO:0000269
name: dGDP transport via dCDP antiport
fast: false
type: Reaction
product: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM e4p c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: C00279
constant: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
name: D-Erythrose 4-phosphate
is: HMDB01321
is: CHEBI:16897
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_f1b376cb_c132_49b9_b40c_5c83ff832e07
type: Species
name: INPP5J
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27124
is: Q15735
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR GCC2cm
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110041#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4

http://identifiers.org/biomodels.db/MODEL1310110041#_01f3c75a_cca0_4cc0_8b69_4bbc982b07ae
is: Q7LG56
initial concentration: NaN
initial amount: NaN
name: RRM2B
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50484
constant: false
has only substance units: false

metaR r0086
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.3
reversible: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
type: Reaction

metaR ABUTD
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000176
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
name: Aminobutyraldehyde dehydrogenase

metaM glu L l
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:29985
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148
name: L-glutamate(1-)

metaR r0595
is described by: ECO:0000000
reversible: false
fast: false
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:

metaR r0655
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110041#

metaR LEUPHELAT2tc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_6bf6b06d_4bc6_44a4_9e20_1d17d70eb9fa
is: Q6ZMU0
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: ALAD
initial amount: NaN
type: Species
is encoded by: hsa:210

http://identifiers.org/biomodels.db/MODEL1310110041#_ae91b488_ad1e_498a_a43b_5cb450f2d1f5
type: Species
is encoded by: hsa:23236
initial amount: NaN
name: PLCB1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaR r1607
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
reversible: true
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#

metaR MTHFDm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110041#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176

metaR GLYt7 311 r
modifier: MODEL1310110041#
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_90ab3f31_85ed_4494_9069_191381325093
is encoded by: hsa:T83654
is: SBO:0000252
name: _T83654_1_e
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_cd1aa05a_01e5_47fe_ad24_b3ca92276511
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: ALDH4A1
is: SBO:0000252
is: P30038
is encoded by: hsa:8659
initial concentration: NaN
boundary condition: true

metaM man g
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16024
constant: false
name: D-mannose
initial concentration: 1.0
is: HMDB00169
has only substance units: false

metaM prostgf2 c
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01139
is: CHEBI:57404
constant: false
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaM 2mp2coa m
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial concentration: 1.0
is: HMDB01011
boundary condition: false
initial amount: NaN
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110041#_88b393b3_57ad_4347_bd63_467d851377ca
constant: false
is: SBO:0000252
is encoded by: hsa:LOC728997
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
name: _LOC728997_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_8e99ca20_2689_43ce_bdff_a36f2e582301
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P32320
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:978
name: CDA

metaR r0594
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction

metaR r0722
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/4.2.3.12
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#

metaM HC02179 c
initial amount: NaN
is: CHEBI:34306
is: SBO:0000247
constant: false
type: Species
name: 20-hydroxy-arachidonate
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false
has only substance units: false

metaR r0441
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: true

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

metaM HC01412 m
boundary condition: false
is: CHEBI:61405
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
name: trans-tetradec-2-enoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN

metaR r0656
is described by: ECO:0000000
fast: false
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
product: MODEL1310110041#

metaR DOLGLCP Uter
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction
reversible: false
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_c7b7d663_3b43_4e2e_a638_238910c4f96f
is encoded by: hsa:159
boundary condition: true
type: Species
is: P30520
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ADSS
initial concentration: NaN
constant: false

metaR r1608
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_623ff889_7f99_4777_82f2_30fe6cdb0535
initial concentration: NaN
has only substance units: false
type: Species
is: P22413
name: ENPP1
is: SBO:0000252
is encoded by: hsa:5167
initial amount: NaN
constant: false
boundary condition: true

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57312
initial concentration: 1.0
is: HMDB01356
initial amount: NaN
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405

http://identifiers.org/biomodels.db/MODEL1310110041#_a8597dfd_4abf_447f_9fa5_b7458eb29a17
name: COX8C
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q7Z4L0
constant: false
is encoded by: hsa:341947

http://identifiers.org/biomodels.db/MODEL1310110041#_7226fe29_1f55_4e31_a0ed_93d3f0619d41
is encoded by: hsa:AA576959
initial amount: NaN
name: _AA576959_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_99a077fd_d80d_46af_84b4_5787bc3b70e6
name: SLC24A2
type: Species
is encoded by: hsa:25769
is: Q9UI40
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM galgluside hs g
type: Species
is: CHEBI:58223
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: C00015
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: galactosyl glucosyl ceramide
has only substance units: false
constant: false
is: HMDB00295
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_c414a9a5_df77_4544_82c8_eb751c5617c1
initial amount: NaN
is: O00767
name: SCD
type: Species
initial concentration: NaN
is encoded by: hsa:6319
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f98ff932_da95_4105_a386_55ea3340a755
name: CA5A
constant: false
boundary condition: true
is: P35218
has only substance units: false
initial concentration: NaN
is encoded by: hsa:763
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0193
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
product: MODEL1310110041#

metaR COAtm
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110041#
name: CoA transporter
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_a4ab4dc9_e2cc_4986_90dd_c7fbab5b7f6b
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _X63359_1_c
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:X63359
type: Species

metaM prpp c
is: HMDB00280
constant: false
boundary condition: false
is: C00119
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58017
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial amount: NaN
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_18b72ecf_bb9e_47d6_af02_e658edcb2bcd
type: Species
is: O75610
is encoded by: hsa:10637
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: LEFTY1

metaR GGH 5DHFl
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT

metaR PHEMEtm
name: Heme transport to cytosol
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV changed name to"tm" to indicate mitochondrial transport NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_5cf8fc25_3bc7_455b_b933_9265b9061a57
is encoded by: hsa:1431
is: SBO:0000252
has only substance units: false
constant: false
is: O75390
name: CS
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
is: HMDB00673
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:30245
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_a8268ee1_fb51_42ba_96fb_22ad4f3874a9
boundary condition: true
is encoded by: hsa:AF080579
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: _AF080579_1_c

metaR 4MPTNLtm
reversible: true
name: 4-methylpentanal transport (mitochondria)
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is: SBO:0000185

metaM nad x
has only substance units: false
initial amount: NaN
is: C00003
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00902
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305

metaM Rtotal2coa c
initial amount: NaN
name: R total 2 coenzyme A
is: CHEBI:60377
constant: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: HMDB00095
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00055
boundary condition: false

metaR GLYtm
kinetic law: MODEL1310110041#
name: glycine passive transport to mitochondria
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185
type: Reaction
fast: false
reversible: true

metaM pro L c
boundary condition: false
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
has only substance units: false
initial amount: NaN
is: HMDB00162
type: Species
initial concentration: 1.0
name: L-proline
is: SBO:0000247
constant: false

metaR COAtn
is: SBO:0000185
name: coenzyme A transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

metaM o2 e
is: HMDB01377
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:15379
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR EX ebastine LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ebastine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_021b5268_c283_4c37_a205_827a57948b86
initial amount: NaN
is encoded by: hsa:65263
constant: false
boundary condition: true
is: Q53H96
type: Species
initial concentration: NaN
has only substance units: false
name: PYCRL
is: SBO:0000252

metaR SPODMx
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
reversible: false
name: superoxide dismutase, peroxisome
reactant: MODEL1310110041#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.15.1.1

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR PAFt
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110041#
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
type: Reaction
kinetic law: MODEL1310110041#

metaM chito2pdol U c
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:12427
has only substance units: false
is: SBO:0000247
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
constant: false
boundary condition: false

metaR MTHFCm
product: MODEL1310110041#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
reversible: true
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_e44886da_d3d2_4df3_acf0_9ce7ec486922
is encoded by: hsa:30061
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: Q9NP59
initial amount: NaN
boundary condition: true
name: SLC40A1

metaM urea c
is: HMDB00294
constant: false
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
name: Urea
is: CHEBI:16199
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: C00086
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_1746db60_4c12_4e21_862d_1fc73e214980
name: ACAD11
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84129
is: Q709F0
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_6924f8a5_a6fc_49bf_9451_1409b12a853a
is encoded by: hsa:1340
type: Species
initial concentration: NaN
is encoded by: hsa:1350
has part: Q53XN1
is encoded by: hsa:9377
is encoded by: hsa:125965
has only substance units: false
has part: Q02221
has part: H0UI06
has part: Q6YFQ2
is encoded by: hsa:1329
is encoded by: hsa:1347
is encoded by: hsa:1345
is encoded by: hsa:1351
has part: Q96KJ9
is encoded by: hsa:4514
is encoded by: hsa:4512
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
boundary condition: true
is encoded by: hsa:1339
is encoded by: hsa:1337
has part: P20674
has part: Q6FGA0
is encoded by: hsa:9167
has part: P24311
is encoded by: hsa:170712
is encoded by: hsa:1346
is encoded by: hsa:84701
has part: Q53YB7
constant: false
is encoded by: hsa:341947
is encoded by: hsa:1327
initial amount: NaN
has part: P12074
has part: Q7GXY8
is: SBO:0000297
has part: P14854
has part: P15954
is encoded by: hsa:1349
has part: P13073
has part: Q7GXZ8
has part: Q7Z4L0
is encoded by: hsa:4513
has part: P09669
has part: P00414
has part: Q8TF08
has part: P24310

metaM bildglcur e
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
is: CHEBI:58471
type: Species
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
is: HMDB03325
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM tag hs e
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:17855
is: SBO:0000247
constant: false
has only substance units: false
name: triglyceride

metaM 5adtststerones e
boundary condition: false
constant: false
type: Species
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
is: SBO:0000247
is: HMDB06278
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

metaR r0653
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaM 44mzym r
is: HMDB01286
name: 14-demethyllanosterol
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:18364
initial concentration: 1.0

metaR r1671
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
reversible: true
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport

metaM ksii core2 pre7 g
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00130
notes: FORMULA: C67H108N5O51SX CHARGE: -2
boundary condition: false
is: HMDB00175
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 7
type: Species

metaM s2l2n2m2m l
notes: FORMULA: C84H136N6O62 CHARGE: -2
name: de-Fuc form of PA6 (w/o peptide linkage)
is: CHEBI:57312
initial amount: NaN
is: HMDB01356
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_48a1ef7b_7375_4517_a891_4792ede1d516
constant: false
boundary condition: true
name: ENPP3
is encoded by: hsa:5169
initial concentration: NaN
has only substance units: false
type: Species
is: Q308M7
is: SBO:0000252
initial amount: NaN

metaR GLUt7l
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
name: Glutamate transport, lysosomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_6162b71a_1208_49f0_bd29_e5f01988d80a
is: SBO:0000252
boundary condition: true
type: Species
name: GLDC
is: P23378
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:2731

metaR URIt
is described by: ECO:0000269
name: uridine facilated transport in cytosol
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185
modifier: MODEL1310110041#
fast: false

metaR KSII CORE2tly
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
fast: false
name: keratan sulfate II (core 2) transport, extracellular to lysosome
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000185

metaR SMPD4
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
name: sphingomyelinase
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ

metaR GK1
is described by: ECO:0000269
modifier: MODEL1310110041#
name: guanylate kinase (GMP:ATP)
reversible: true
fast: false
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_af58d749_08c1_49fb_9f98_0c28dcf846db
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3988
is: P38571
boundary condition: true
name: LIPA
initial concentration: NaN
initial amount: NaN
type: Species

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_e53a8811_ad40_4d18_bc0b_9cb8282aa4f8
constant: false
name: SLC34A2
type: Species
boundary condition: true
is encoded by: hsa:10568
has only substance units: false
initial amount: NaN
is: O95436
is: SBO:0000252
initial concentration: NaN

metaR r0652
modifier: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
kinetic law: MODEL1310110041#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110041#
reactant: MODEL1310110041#

metaR COAtl
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
name: CoA transport in lysosome via diffusion
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
reversible: true
kinetic law: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f6fbd4a8_5d74_44d2_87b2_262b3f07a8c3
initial concentration: NaN
boundary condition: true
is: Q9H008
is: SBO:0000252
initial amount: NaN
name: LHPP
has only substance units: false
is encoded by: hsa:64077
constant: false
type: Species

metaM 25hvitd3 e
is: SBO:0000247
is: HMDB03550
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17933
name: calcidiol
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

metaM o2 c
is: C00007
type: Species
initial concentration: 1.0
is: HMDB01377
initial amount: NaN
boundary condition: false
is: CHEBI:15379
has only substance units: false
name: O2
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_c1e431b4_6a12_4459_91b6_411529202668
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348
type: Species
initial amount: NaN
constant: false
name: FOLR1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_df7c1eb8_25ed_4b03_8d87_cbd6a8ea01af
type: Species
initial amount: NaN
is encoded by: hsa:478
name: ATP1A3
initial concentration: NaN
boundary condition: true
has only substance units: false
is: B7Z2T0
constant: false
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM ksii core4 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
is: C00130
initial concentration: 1.0
is: HMDB00175
type: Species
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110041#_e76d06a3_944f_4112_b832_6b97369d85da
is encoded by: hsa:6513
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC2A1
is: P11166

metaR KYNAKGAT
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
kinetic law: MODEL1310110041#
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_95d4d278_3949_45a1_bd55_809dafacb80c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: AKR1C4
is: P17516
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1109

metaM 5adtststerones c
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032

metaR DM T antigen g
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110041#

metaR FAOXC160
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110041#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110041#
is described by: ECO:0000269
fast: false
is: SBO:0000176
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110041#_0ac957a9_822b_4a8b_b3e5_c1718f378fb8
constant: false
boundary condition: true
name: CPT1B
has only substance units: false
type: Species
initial concentration: NaN
is: Q53FV7
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1375

metaM arach c
is: HMDB02212
is: CHEBI:32360
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: arachidate
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_d739da56_30a4_4955_b7bc_74308dc5f4d3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55349
name: CHDH
is: Q8NE62
constant: false

metaM 4mop m
has only substance units: false
type: Species
is: HMDB00695
boundary condition: false
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR CERT1rt
fast: false
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaM HC02204 e
type: Species
is: CHEBI:27624
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_cdb08a99_e231_4417_bfcf_fc7e712acf46
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10195
name: ALG3
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR 5MTAte
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110041#
name: Transport of 5-S-methyl-5-thioadenosine
kinetic law: MODEL1310110041#

metaR BTNt2
fast: false
name: Biotin reversible transport via proton symport
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#
is described by: ECO:0000269

metaR UGCG
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
fast: false
name: Ceramide glucosyltransferase
type: Reaction
reversible: false
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.80
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR r0650
is described by: ECO:0000000
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
reactant: MODEL1310110041#

metaR LDH D
reversible: true
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.2.4
name: D-lactate dehydrogenase
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)

metaM stcoa m
name: Stearoyl-CoA (n-C18:0CoA)
boundary condition: false
is: C00412
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN
is: HMDB01114
is: CHEBI:57394

metaM dheas e
initial concentration: 1.0
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: CHEBI:57905
is: SBO:0000247
constant: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial amount: NaN
type: Species
is: HMDB01032
has only substance units: false
boundary condition: false

metaR RE2660N
reversible: true
name: RE2660
fast: false
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:

metaR r1116
kinetic law: MODEL1310110041#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is described by: ECO:0000000
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_ff1e4a4f_ebc7_4cd6_8126_c9f97da8d3b7
is: P10696
constant: false
name: ALPPL2
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:251

metaM HC00664 c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
is: SBO:0000247
type: Species
boundary condition: false
name: D-tagatofuranose 6-phosphate(2-)
is: CHEBI:58695

metaR PROSTGH2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
product: MODEL1310110041#
fast: false
reversible: true
name: Prostaglandin H2 transport

metaR GLYCtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
name: glycerol transport
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#

metaR NADtpu
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
name: NAD transporter, peroxisome
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ

metaM naglc2p U c
initial concentration: 1.0
boundary condition: false
is: CHEBI:18278
is: SBO:0000247
type: Species
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
constant: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
initial amount: NaN

metaM nad r
name: NAD(1-)
constant: false
initial concentration: 1.0
is: HMDB00902
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
type: Species
is: SBO:0000247
is: CHEBI:57540

http://identifiers.org/biomodels.db/MODEL1310110041#_455a35e8_6096_4927_b1d6_4004a43cb8f4
is encoded by: hsa:1375
is: B7Z5T8
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: CPT1B
is: SBO:0000252
initial amount: NaN
type: Species

metaR FMNALKPle
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
name: FMNALKPle
fast: false

metaM 25hvitd3 c
is: SBO:0000247
initial concentration: 1.0
is: HMDB03550
boundary condition: false
name: calcidiol
type: Species
constant: false
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
is: CHEBI:17933
initial amount: NaN

metaR r1670
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: true
is described by: ECO:0000000

metaR PAIL4P HStn
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM retinol c
is: HMDB00305
constant: false
boundary condition: false
name: retinol
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:50211

metaM 1glyc hs e
name: 1 acyl phosphoglycerol
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
type: Species
initial amount: NaN
constant: false
is: CHEBI:16236
has only substance units: false
is: HMDB00108

http://identifiers.org/biomodels.db/MODEL1310110041#_394aa450_4f8c_4b8f_8259_2f7bf88d6fda
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: B4DG68
initial amount: NaN
is encoded by: hsa:4842
constant: false
has only substance units: false
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110041#_a5c6a699_b94e_4732_adb4_c643072ebcc6
type: Species
is: SBO:0000252
is: P22102
is encoded by: hsa:2618
name: GART
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR FAOXC1811603m
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
name: Beta oxidation fatty acid
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_2a68b64b_3bb2_4e71_a44a_ec849ec5f890
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR r1117
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reversible: true
name: Facilitated diffusion
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaM arach e
is: CHEBI:32360
constant: false
has only substance units: false
type: Species
is: HMDB02212
initial amount: NaN
boundary condition: false
name: arachidate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
is: SBO:0000247

metaM pmtcoa c
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: C00154
is: SBO:0000247
is: HMDB01338
initial concentration: 1.0
constant: false
is: CHEBI:3454
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f378beaa_d751_471f_bf57_6b8597877eba
initial amount: NaN
constant: false
name: _AA081045_1_m
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA081045

metaR LYSOXp
name: L-lysine oxidase, peroxisomal
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM

metaR r2017
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c2bdf831_4422_4c0a_b4f7_be9297c25aa4
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
name: _AA526438_1_c
initial concentration: NaN
is encoded by: hsa:AA526438
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a4ed60a0_e923_4efa_a981_257842b60753
is: B3KT84
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:195814
name: SDR16C5
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaM prpp e
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:58017
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)

metaR AGTim
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.44
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaM bglc e
is: CHEBI:57449
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: beta-glucans
initial amount: NaN
boundary condition: false

metaM dheas c
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial concentration: 1.0
is: CHEBI:57905
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB01032

metaR GGH 6DHFl
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
type: Reaction
fast: false
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#

metaR RE0453C
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: RE0453
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000

metaR G14T13g
reactant: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM spmd c
is: HMDB01257
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial concentration: 1.0
is: C00315
is: SBO:0000247
name: Spermidine
type: Species
initial amount: NaN
constant: false
is: CHEBI:57834

http://identifiers.org/biomodels.db/MODEL1310110041#_d52d68d0_447f_4c13_acba_c8d96009a513
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4129
is: SBO:0000252
is: P27338
name: MAOB
has only substance units: false
initial concentration: NaN
constant: false

metaM retinol e
constant: false
is: SBO:0000247
boundary condition: false
name: retinol
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
is: HMDB00305
is: CHEBI:50211
has only substance units: false
initial concentration: 1.0

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_31d04717_3caa_442a_b727_7e56d4976935
is: SBO:0000252
initial amount: NaN
is: E9PB82
constant: false
boundary condition: true
name: HSD17B4
type: Species
is encoded by: hsa:3295
has only substance units: false
initial concentration: NaN

metaM urea e
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
is: HMDB00294
initial concentration: 1.0
has only substance units: false
constant: false
name: Urea
is: C00086
is: CHEBI:16199
boundary condition: false
type: Species
is: SBO:0000247

metaM bildglcur c
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:58471
is: HMDB03325
constant: false
type: Species
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin

metaR DKMPPD
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_11ae6022_7580_4a45_8b11_319f21884856
is: Q8NB10
type: Species
has only substance units: false
name: PDE1C
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5137
constant: false
is: SBO:0000252
initial amount: NaN

metaR ADSS
product: MODEL1310110041#
fast: false
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.3.4.4
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110041#
name: adenylosuccinate synthase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_8cb0a345_19a1_45ea_a370_f72300b1ad28
initial amount: NaN
name: GAMT
is encoded by: hsa:2593
is: Q14353
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57973
type: Species
initial concentration: 1.0
is: HMDB01198
is: SBO:0000247
name: leukotriene C4(2-)
initial amount: NaN

metaR r1824
product: MODEL1310110041#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_074eca66_ada1_4b6a_9cb3_37af6d175c18
name: ALAD
boundary condition: true
is: P13716
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:210
is: SBO:0000252
type: Species

metaR GALtly
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110041#
name: galactose efflux from lysosome
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
kinetic law: MODEL1310110041#
type: Reaction

metaR r1007
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110041#

metaM ksi pre10 g
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 10
is: CHEBI:58053
is: HMDB00175
is: C00130
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_7acfbbf3_2ff3_4eca_92a3_4f6a1fc2dfa1
is encoded by: hsa:5335
has only substance units: false
initial concentration: NaN
is: P19174
is: SBO:0000252
boundary condition: true
type: Species
name: PLCG1
constant: false
initial amount: NaN

metaM o2 n
name: dioxygen
has only substance units: false
is: CHEBI:15379
is: HMDB01377
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM xol7ah2al c
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
constant: false
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
is: CHEBI:27428
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR PPCOAOm
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_5ddbe68d_5212_4c82_b853_699a8ef94ea6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:39
type: Species
name: ACAT2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q9BWD1

metaR NACHEXA13ly
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: false
fast: false
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110041#_b84f42b5_bc4a_4776_90c6_162e27a1c4c1
type: Species
is encoded by: hsa:3032
has only substance units: false
constant: false
is: P55084
initial concentration: NaN
boundary condition: true
name: HADHB
is: SBO:0000252
initial amount: NaN

metaR r1823
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#

metaM acgam c
is: CHEBI:17411
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-glucosamine
is: SBO:0000247
is: HMDB00215
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false

metaR ARACHCRNt
kinetic law: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110041#
fast: false
type: Reaction

metaR r1008
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: Facilitated diffusion
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
reversible: false

metaR ADNtm
name: adenosine facilated transport in mitochondria
reversible: true
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
modifier: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_21d9007d_9a23_4656_9c29_e8c73b02a6f5
name: ATP1A4:ATP1B1
initial amount: NaN
is: SBO:0000297
boundary condition: true
initial concentration: NaN
has part: Q13733
is encoded by: hsa:480
constant: false
type: Species
has only substance units: false

metaM o2 m
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:15379
name: O2
is: C00007

metaM pmtcrn x
is: SBO:0000247
name: L-palmitoylcarnitine
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial concentration: 1.0
is: CHEBI:17490
is: HMDB00222

metaM duri e
name: Deoxyuridine
is: HMDB00012
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00526
is: CHEBI:16450
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
boundary condition: false

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
name: Facilitated diffusion
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.7.72
kinetic law: MODEL1310110041#
reversible: true
fast: false
is described by: ECO:0000000

metaR r0932
name: Transport reaction
type: Reaction
reversible: true
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_be684ff5_c9f6_4b1a_bb0e_04281a2c7ab3
is encoded by: hsa:481
has only substance units: false
initial amount: NaN
name: ATP1B1
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: A3KLL5

metaM spmd e
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01257
is: CHEBI:57834
name: Spermidine
has only substance units: false
is: C00315
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_d10fbc9d_b0fb_41a0_a8be_e0a5b764f8c7
is encoded by: hsa:374907
initial amount: NaN
has only substance units: false
name: B3GNT8
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_3352278a_efdb_4061_a70e_72a9ecae263f
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: Q96G03
boundary condition: true
constant: false
name: PGM2
is encoded by: hsa:55276

metaR r2399
type: Reaction
product: MODEL1310110041#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR RE1533M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: RE1533
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110041#
type: Reaction

metaR HDCAter
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
name: palmitate ER export
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_95e3f126_b8c8_41ed_a41b_d5db72a53908
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79695
name: GALNT12
boundary condition: true
has only substance units: false
type: Species
is: Q8IXK2
constant: false
initial amount: NaN

metaM ksi deg8 l
constant: false
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
name: keratan sulfate I, degradation product 8
has only substance units: false
initial amount: NaN
is: HMDB00143
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_193bd4a7_bdf5_4fad_bfee_5135a808c259
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P26439
initial amount: NaN
name: HSD3B2
type: Species
is encoded by: hsa:3284
constant: false
is: SBO:0000252

metaM HC02187 e
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:28774
name: reverse-triiodthyronine
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM 3hpcoa m
is: SBO:0000247
is: HMDB06807
name: 3-hydroxypropanoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:58528
constant: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
boundary condition: false
initial amount: NaN
type: Species

metaM stcoa c
name: Stearoyl-CoA (n-C18:0CoA)
type: Species
is: SBO:0000247
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01114
has only substance units: false
is: C00412
constant: false
is: CHEBI:57394

metaR RETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reversible: false
name: Retinol transport via faciliated diffusion
reactant: MODEL1310110041#
type: Reaction
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a8d6702b_6547_492f_9488_e8fa8c952a1e
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q9BY49
initial concentration: NaN
is: SBO:0000252
name: PECR
is encoded by: hsa:55825
initial amount: NaN

metaM 2mpdhl m
name: S-(2-Methylpropanoyl)-dihydrolipoamide
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17577
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
boundary condition: false
constant: false

metaR r0931
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_1ff82140_c4cc_4364_a001_d36b7ec7ed68
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q9H845
name: ACAD9
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:28976
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5fa32a28_deaf_4626_b5a4_8372d8c92129
is encoded by: hsa:6391
has part: O14521
name: SDHA:SDHB:SDHC:SDHD
type: Species
is: SBO:0000297
has only substance units: false
constant: false
has part: Q99643
has part: P31040
initial concentration: NaN
has part: P21912
initial amount: NaN
is encoded by: hsa:6392
is encoded by: hsa:6389
is encoded by: hsa:6390
boundary condition: true

metaR AG13T4g
product: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
type: Reaction

metaM gdpddman c
has only substance units: false
is: HMDB01346
initial concentration: 1.0
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
initial amount: NaN
constant: false
type: Species
is: CHEBI:57964

metaM leuktrC4 c
is: CHEBI:57973
name: leukotriene C4(2-)
initial amount: NaN
type: Species
is: HMDB01198
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
is: C06028
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:27969
has only substance units: false
name: Mesaconyl-CoA

metaR LYStn
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
name: L-lysine transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
type: Reaction
is: SBO:0000185

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM ksi deg11 l
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate I, degradation product 11
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
constant: false
is: HMDB00143

metaM hco3 c
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17544
is: C00288
name: Bicarbonate
constant: false
is: HMDB00595
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR S6T15g
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.8.2.21

metaR ACN13ACNGALGBSIDEtg
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110041#
reversible: true
name: acn13acngalgbside hs intracellular transport
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6fe5de30_2d5a_4fcd_bee2_509e34134589
is: SBO:0000252
is encoded by: hsa:10682
constant: false
type: Species
has only substance units: false
is: Q15125
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: EBP

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR DNDPt29m
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110041#
name: dCDP transport via dADP antiport
is: SBO:0000185

metaR GALASE4ly
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is: SBO:0000176
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110041#
type: Reaction

metaR FUT15g
name: Galactoside 2-alpha-L-fucosyltransferase 1
is: SBO:0000176
reversible: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69
fast: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
type: Reaction
reactant: MODEL1310110041#

metaR CORE3GTg
is described by: ECO:0000000
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
reversible: false
fast: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
kinetic law: MODEL1310110041#

metaR r1716
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM duri c
has only substance units: false
name: Deoxyuridine
initial concentration: 1.0
is: HMDB00012
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
constant: false
is: C00526
is: CHEBI:16450
type: Species
boundary condition: false

metaM citr L m
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN
is: CHEBI:16349
is: HMDB00904
has only substance units: false
boundary condition: false
name: L-citrulline
type: Species

metaR PSP L
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.3
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
name: phosphoserine phosphatase (L-serine)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
is: SBO:0000176

metaR ACS
name: acetyl-CoA synthetase
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) or (55902.2) or (55902.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 4 AUTHORS: PMID:10843999,PMID:12623130 NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269

metaR GLNt4
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
modifier: MODEL1310110041#
name: L-glutamine reversible transport via sodium symport
fast: false
is: SBO:0000185
reversible: false

metaR r2397
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110041#_e4a586c1_32aa_4956_8ad7_3b841d9d0b53
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: UPB1
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: B3KNC1
is encoded by: hsa:51733

metaR r0321
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.3.5.2
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16

metaR TALA
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_3dc2762c_ddb5_44a9_882c_684c150c354c
boundary condition: true
is: O95168
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4710
initial amount: NaN
type: Species
name: NDUFB4
constant: false

metaR SPODMn
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000269
modifier: MODEL1310110041#
name: superoxide dismutase, nuclear
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR AHEXASEly
kinetic law: MODEL1310110041#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
reactant: MODEL1310110041#
product: MODEL1310110041#

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR KSIt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
name: keratan sulfate I transport, golgi to extracellular

http://identifiers.org/biomodels.db/MODEL1310110041#_586a8b48_75b5_41fc_a7bb_706b523b9f82
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: BLVRB
constant: false
is encoded by: hsa:645
initial amount: NaN
is: P30043
boundary condition: true
type: Species

metaR GTHPm
type: Reaction
modifier: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase, mitochondria

http://identifiers.org/biomodels.db/MODEL1310110041#_0e0032ce_8d83_4ad0_bd6f_db6544731472
constant: false
is encoded by: hsa:NM 001929
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: _NM_001929_1_c

metaM ksii core2 deg3 l
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false
is: HMDB00143
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_c535e2da_0e14_4713_b8bb_2821b2e6b432
boundary condition: true
name: SLC3A2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P08195
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:6520

metaM 25hvitd3 m
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17933
name: calcidiol
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 EHMN_ABBREVIATION: C01561
is: HMDB03550
type: Species
boundary condition: false

metaM 56dura c
type: Species
initial amount: NaN
is: HMDB00076
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 5,6-dihydrouracil
constant: false
is: CHEBI:15901
is: SBO:0000247
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429

http://identifiers.org/biomodels.db/MODEL1310110041#_9d52aaef_8a50_4c93_87ed_0086d99c044e
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: B3KN25
is encoded by: hsa:10390
initial concentration: NaN
constant: false
name: CEPT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_1c11ddd5_6b3d_46fd_b5ba_e3e7c8b90006
is: Q3KQV9
boundary condition: true
initial amount: NaN
is encoded by: hsa:91373
is: SBO:0000252
name: UAP1L1
constant: false
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_17e84552_0d12_4f0b_a5e0_6abbc73a6c0f
name: PEMT
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9UBM1
boundary condition: true
type: Species
is encoded by: hsa:10400
has only substance units: false
initial amount: NaN

metaR PPItm
product: MODEL1310110041#
name: diphopshate transporter, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
is: SBO:0000185

metaM ksi pre20 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 20
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
type: Species
constant: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110041#_a34bf1d9_a1a7_44b6_9c95_c1f27118320f
initial amount: NaN
type: Species
has only substance units: false
is: B7Z9T9
is: SBO:0000252
constant: false
initial concentration: NaN
name: PDE6B
boundary condition: true
is encoded by: hsa:5158

metaR r1677
is: SBO:0000185
reactant: MODEL1310110041#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaR SIAASEly
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
name: sialidase, lysosomal
modifier: MODEL1310110041#

metaM o2 r
constant: false
is: HMDB01377
initial amount: NaN
is: C00007
is: CHEBI:15379
boundary condition: false
type: Species
name: O2
has only substance units: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247

metaM fadh2 m
boundary condition: false
is: CHEBI:58307
is: C01352
is: HMDB01197
initial concentration: 1.0
constant: false
has only substance units: false
name: Flavin adenine dinucleotide reduced
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
initial amount: NaN

metaR LDH L
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is described by: ECO:0000000
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
fast: false
name: L-lactate dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27

metaR NACHEXA18ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false

metaM tyr L e
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
name: L-tyrosine
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
is: CHEBI:17895
type: Species

metaR 3MOPte
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
name: Transport of 3-methyl-2-oxopentanoate
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
product: MODEL1310110041#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110041#_7d3db0a6_4fdc_4bd3_93ea_a6f2aaac85be
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AL050025
initial amount: NaN
has only substance units: false
boundary condition: true
name: _AL050025_1_c

metaR ACN13ACNGALGBSIDEte
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
name: acn13acngalgbside hs transport
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

metaR H2Otly
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: H2O transport, lysosomal
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110041#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_a1a2fd6c_f775_41d6_a8e4_bfa4f9bc7f35
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:115111
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC26A7

metaM HC01609 e
initial concentration: 1.0
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: UroporphyrinogenI
constant: false
type: Species
boundary condition: false
is: CHEBI:28766

metaM arachd r
initial concentration: 1.0
is: CHEBI:32395
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
is: HMDB01043
has only substance units: false
boundary condition: false
initial amount: NaN

metaM citr L e
type: Species
is: SBO:0000247
name: citr_L[e]
boundary condition: false
constant: false
has only substance units: false
is: HMDB00904
is: CHEBI:16349
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_c33ea7d9_5eda_4183_876c_e1e4719de9bd
initial amount: NaN
is: SBO:0000252
type: Species
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_97798add_232c_448d_9460_4dfbb2977c49
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5631
boundary condition: true
initial concentration: NaN
constant: false
is: P60891
name: PRPS1
type: Species
has only substance units: false

metaR r1678
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaR COAtr
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
name: COA transporter, endoplasmic reticulum
reversible: true

metaM pan4p c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C01134
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942
type: Species
name: Pantetheine 4'-phosphate
is: HMDB01416
is: SBO:0000247
boundary condition: false
constant: false

metaR P450SCC1m
reversible: true
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
name: cholesterol monooxygenase
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000134

metaM aacoa m
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
is: HMDB01484
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57286
initial concentration: 1.0
type: Species

metaR AG13T18g
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110041#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#

metaR RE0453M
type: Reaction
is: SBO:0000176
reactant: MODEL1310110041#
name: RE0453
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_391742d7_459c_4ba5_b7aa_2ad529b093b8
type: Species
is: SBO:0000252
name: PPT2
has only substance units: false
is encoded by: hsa:9374
is: Q9UMR5
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM Rtotal3coa c
type: Species
is: SBO:0000247
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: HMDB01448
initial amount: NaN
is: CHEBI:16189
constant: false
boundary condition: false
has only substance units: false
name: R total 3 Coenzyme A
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_f5850e0d_ec5e_412b_9dba_15c23e3267c6
is encoded by: hsa:30
constant: false
is: Q96CA6
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: ACAA1
initial concentration: NaN
is: SBO:0000252

metaM 5mdr1p c
initial amount: NaN
type: Species
is: CHEBI:58533
initial concentration: 1.0
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
is: HMDB00963
has only substance units: false
is: C04188
is: SBO:0000247
constant: false
boundary condition: false
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate

metaM ksii core2 deg2 l
initial amount: NaN
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 2
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
has only substance units: false

metaR MI14PP
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
name: inositol-1,4-bisphosphate 1-phosphatase
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.57
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM HC02203 c
is: SBO:0000247
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
is: CHEBI:27820
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: prostaglandin-a2

metaM C05279 m
has only substance units: false
is: CHEBI:28387
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
boundary condition: false
is: HMDB11123
initial concentration: 1.0
constant: false
initial amount: NaN

metaM CE5120 m
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110041#_04636c13_9edf_4d19_a812_42582053b7be
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI285872
initial concentration: NaN
name: _AI285872_1_c
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_110cc611_ab8d_4c74_be74_709368689e14
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM 3hmp m
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
has only substance units: false
name: 3-hydroxy-2-methylpropanoate
is: HMDB00023
boundary condition: false
constant: false
initial concentration: 1.0

metaM HC00460 c
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58044
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
boundary condition: false
name: 2,5-dihydroxybenzoate
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_0e953b50_c956_42f0_9461_667ace3897c3
initial amount: NaN
constant: false
name: GGH
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q92820
is encoded by: hsa:8836
is: SBO:0000252

metaM paps c
constant: false
type: Species
is: CHEBI:58339
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
initial amount: NaN
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_46a8c72f_e6f0_460c_9158_27f10c97560c
initial concentration: NaN
is: O75891
name: ALDH1L1
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10840
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_e45e5764_a5de_4f59_866a_f67527b6b71d
has only substance units: false
name: PANK2
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:80025
boundary condition: true
is: SBO:0000252
is: Q6P1K9

metaR LNLCCRNt
is described by: ECO:0000269
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110041#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_46c14e19_6025_4ce3_bf5e_e5c960a44203
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2356
boundary condition: true
is: Q05932
has only substance units: false
name: FPGS

metaM pro L e
type: Species
name: L-proline
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
constant: false
is: HMDB00162
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_386b14f9_9f7c_460e_b49f_56ee4c868e8a
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: B2R6S5
is: SBO:0000252
name: CMPK1
is encoded by: hsa:51727
has only substance units: false
initial amount: NaN

metaR 5HOXINDACTO2OX
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.3.1
reversible: false
fast: false
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
kinetic law: MODEL1310110041#
is described by: ECO:0000304
modifier: MODEL1310110041#
is: SBO:0000176

metaR HIStN1
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110041#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110041#
name: Histidine transport (Na, H coupled)
product: MODEL1310110041#

metaM nad m
is: SBO:0000247
is: C00003
is: HMDB00902
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
has only substance units: false
constant: false
name: Nicotinamide adenine dinucleotide

metaM lnlc e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00673
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:30245
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
name: linoleate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_b308630d_694a_4a27_94f5_d4096c796c7f
has only substance units: false
initial concentration: NaN
name: HSD3B1
is encoded by: hsa:3283
is: SBO:0000252
constant: false
initial amount: NaN
is: P14060
type: Species
boundary condition: true

metaM tyr L c
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
boundary condition: false
is: SBO:0000247
constant: false
name: L-tyrosine
initial amount: NaN
is: CHEBI:17895
is: HMDB00158

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_c47e7bff_91d9_4423_8d02_5300bfec1006
is encoded by: hsa:1583
initial concentration: NaN
name: CYP11A1
initial amount: NaN
is: G3XAD7
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR r0934
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110041#
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR ACOAD1fm
reversible: false
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
product: MODEL1310110041#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r1954
fast: false
reversible: false
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_2c236e91_c5ca_4ed9_b783_4424e18d9700
type: Species
initial concentration: NaN
has only substance units: false
name: SLC37A4
is: SBO:0000252
is: A8K0S7
is encoded by: hsa:2542
boundary condition: true
initial amount: NaN
constant: false

metaM pan4p e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:47942
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: C01134
boundary condition: false
has only substance units: false
is: HMDB01416
initial amount: NaN
name: Pantetheine 4'-phosphate
type: Species

metaR PI34P5K
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#

metaM mlthf m
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
is: CHEBI:15636
type: Species
constant: false
boundary condition: false
is: C00143
has only substance units: false
is: SBO:0000247
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

metaM acgam e
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00215
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: CHEBI:17411
initial concentration: 1.0
type: Species

metaM HC02203 e
is: SBO:0000247
type: Species
constant: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: prostaglandin-a2
has only substance units: false

metaM HC02187 c
initial concentration: 1.0
name: reverse-triiodthyronine
is: CHEBI:28774
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_18aa34c4_8ad8_4eff_80d9_f93e9327e426
is: B3KXN9
constant: false
is encoded by: hsa:84890
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: ADO

metaR PRGSTRNt
name: Progesterone transport
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR r1781
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
modifier: MODEL1310110041#
fast: false

metaR COAtp
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: coenzyme A transport, peroxisomal
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_2918c215_5585_41dc_8dbf_c55bc13978d5
name: _BE042354_1_m
boundary condition: true
is encoded by: hsa:BE042354
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaM CE5119 m
has only substance units: false
is: CHEBI:12947
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
type: Species
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110041#_ebf2babc_4174_479b_9e09_9aa7f3d266f3
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6487

metaR r1648
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_25ec618a_93b7_41d2_87f5_f2ed3c1d7e45
boundary condition: true
has part: Q02153
initial concentration: NaN
is encoded by: hsa:2977
constant: false
initial amount: NaN
name: GUCY1A2:GUCY1B3
is: SBO:0000297
type: Species
is encoded by: hsa:2983
has only substance units: false
has part: P33402

metaR r0627
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reversible: true

metaR DOLPMT1 Uer
is described by: ECO:0000000
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.258
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110041#_f7289b62_c32d_402f_bf55_0a1cbe5e53f4
name: PYCR2
type: Species
boundary condition: true
constant: false
is encoded by: hsa:29920
is: Q96C36
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6cae4843_b138_44f7_be3c_6762dbbba289
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9HBH5
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:57665
name: RDH14

metaR r1635
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
fast: false
modifier: MODEL1310110041#

metaM HC02213 e
type: Species
constant: false
initial amount: NaN
name: prostaglandin-e3
boundary condition: false
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r1575
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_b517ca46_69b8_4e7a_bb00_a4d39334032e
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: P51160
type: Species
name: PDE6C
is encoded by: hsa:5146
is: SBO:0000252
initial amount: NaN

metaM CE5586 c
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial amount: NaN
constant: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:58732

metaM spc hs e
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false
type: Species
name: sphingosylphosphorylcholine
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_3c051d33_1129_47d0_8530_2312a441072a
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8803
initial concentration: NaN
constant: false
is: E5KS60
boundary condition: true
initial amount: NaN
name: SUCLA2
type: Species

metaR r0470
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction

metaR CYTK1
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
name: cytidylate kinase (CMP)
fast: false
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM 3pg m
is: SBO:0000247
type: Species
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: CHEBI:58272
constant: false
initial concentration: 1.0
is: HMDB00807
initial amount: NaN
boundary condition: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
has only substance units: false

metaM gluside hs c
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368

metaM coa l
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
name: coenzyme A(4-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57287
is: HMDB01423
has only substance units: false
is: SBO:0000247

metaR DNDPt22m
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: dTDP transport via dUDP antiport
reversible: false
fast: false
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110041#
is: SBO:0000185

metaR r1291
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000185
fast: false
name: Postulated transport reaction

metaM o2 x
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15379
type: Species
name: O2
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
is: HMDB01377

metaR r1647
reversible: true
modifier: MODEL1310110041#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_dbea6543_3bc1_4009_9d6a_864aa7c3f520
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: _AA788780_1_c
is encoded by: hsa:AA788780
initial amount: NaN

metaR r1636
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110041#
modifier: MODEL1310110041#

metaR UMPK7
kinetic law: MODEL1310110041#
fast: false
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110041#
name: UMP kinase (dGTP)
type: Reaction

metaM thymd e
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:17748
is: C00214
has only substance units: false
constant: false
is: HMDB00273
name: Thymidine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_1743d2e6_0d2a_4003_a50b_73df6cbfc3bb
initial amount: NaN
name: MAT2B
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:27430

metaM creat e
constant: false
initial concentration: 1.0
name: creatine
initial amount: NaN
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
is: HMDB00064
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaR r1421
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
name: Free diffusion
reactant: MODEL1310110041#
reversible: true

metaR r1574
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR LEUTA
type: Reaction
reversible: true
is: SBO:0000176
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is described by: ECO:0000269
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_54486866_e672_4f55_b471_a32d754d5c1d
boundary condition: true
initial concentration: NaN
type: Species
name: HSD17B4
is encoded by: hsa:3295
is: E9PB82
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_b41c5d88_9430_4082_af41_426e1c616a89
is: P41222
is encoded by: hsa:5730
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: PTGDS
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_4e1a93e0_e142_4e5b_84ad_928411ed01bd
boundary condition: true
initial concentration: NaN
type: Species
name: ALG6
is: SBO:0000252
constant: false
is encoded by: hsa:29929
is: Q9Y672
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_dd4fb60a_37fb_4051_b0e7_618cc5eaf082
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR PROSTGE1t
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110041#
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110041#

metaM 5mthf c
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
is: CHEBI:3729
is: C00440
constant: false
boundary condition: false
is: HMDB01396

metaM dudp m
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
is: HMDB01000
name: dUDP(3-)
is: CHEBI:60471
initial concentration: 1.0

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ed98d895_1f04_4a39_9a1e_b71759203ee6
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: NDUFB2
has only substance units: false
is: H7C5B8
is encoded by: hsa:4708
is: SBO:0000252

metaM dctp c
initial amount: NaN
is: HMDB00998
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16311
is: C00458
name: dCTP
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_541f7046_eaad_4a82_968b_684c4b2586e9
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: P15104
boundary condition: true
name: GLUL
has only substance units: false
constant: false
is encoded by: hsa:2752

metaR r0629
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.6.1.22
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110041#
is: SBO:0000176

metaR RE3568C
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110041#
name: RE3568
reactant: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000

metaR r1637
product: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR AHEXASE2ly
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4fef419d_e067_4fe1_ab02_12b769c86e86
type: Species
is: A7E2E5
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PDE3B
is encoded by: hsa:5140

metaM HC02213 c
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28031

metaR VALTAm
reversible: true
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: valine transaminase, mitochondiral
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction

metaR RADH
name: retinal dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
product: MODEL1310110041#

metaM xu5p D c
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: CHEBI:57737
name: D-xylulose 5-phosphate(2-)
type: Species
initial concentration: 1.0
is: HMDB00868
has only substance units: false

metaM apoC c
name: Apocarboxlase (no lys residue)
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:33190
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
is: HMDB11111

metaM asn L e
initial amount: NaN
constant: false
name: L-asparagine
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17196
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR r0472
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110041#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
fast: false
is: SBO:0000176

metaM pail hs c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
type: Species
is: CHEBI:57880

http://identifiers.org/biomodels.db/MODEL1310110041#_b26f75f8_ba11_49c9_80d7_d8881b72436a
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GALNT10
is: Q86SR1
has only substance units: false
is encoded by: hsa:55568
constant: false
boundary condition: true

metaR RPE
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176
name: ribulose 5-phosphate 3-epimerase
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#

metaM imp c
is: SBO:0000247
constant: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: CHEBI:58053
has only substance units: false
name: IMP
boundary condition: false
is: C00130
initial amount: NaN
type: Species
is: HMDB00175
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_0ee50f27_b5b3_4d31_8a46_69552e52a69a
boundary condition: true
type: Species
name: VNN3:VNN2:VNN1
initial amount: NaN
has only substance units: false
is: SBO:0000297
constant: false
initial concentration: NaN
is encoded by: hsa:55350

metaM ha pre1 e
constant: false
is: CHEBI:16126
boundary condition: false
initial concentration: 1.0
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR CYTK3
type: Reaction
reversible: true
product: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
name: cytidylate kinase (CMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
fast: false
modifier: MODEL1310110041#

metaR ADKd
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

metaR RE1897C
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: RE1897
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
fast: false
reactant: MODEL1310110041#
is: SBO:0000176

metaR CSm
is version of: http://identifiers.org/ec-code/2.3.3.1
name: citrate synthase
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000134
type: Reaction
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is: SBO:0000176

metaR r1638
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c13a898e_0912_4bad_acc8_bba84edae266
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: PDE9A
is encoded by: hsa:5152

metaR r2443
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110041#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
reversible: false
kinetic law: MODEL1310110041#
fast: false
type: Reaction

metaR PItg
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
name: phosphate transport, Golgi apparatus
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110041#

metaR r1649
reversible: true
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110041#

metaR SQLSr
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
name: Squalene synthase
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.5.1.21

metaR r0517
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_5ebcca5b_a7f1_491a_99bf_fb9ff01fec04
initial concentration: NaN
constant: false
has only substance units: false
is: Q9Y231
is encoded by: hsa:10690
initial amount: NaN
name: FUT9
is: SBO:0000252
boundary condition: true
type: Species

metaM creat c
boundary condition: false
initial concentration: 1.0
name: creatine
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919
is: SBO:0000247
constant: false
is: HMDB00064

metaM nad c
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: CHEBI:57540
initial amount: NaN
is: HMDB00902
is: C00003

metaR r1576
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR AG13T12g
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110041#
reversible: false

metaM thymd c
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:17748
is: C00214
constant: false
is: HMDB00273
name: Thymidine
initial concentration: 1.0
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214

metaM mpdol U c
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
is: CHEBI:18396
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM glyc S e
is: HMDB06372
initial concentration: 1.0
initial amount: NaN
name: (S)-Glycerate
constant: false
is: CHEBI:33871
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: 0
boundary condition: false

metaM man1p c
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
is: SBO:0000247
name: D-Mannose 1-phosphate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:35374
has only substance units: false
is: HMDB06330

http://identifiers.org/biomodels.db/MODEL1310110041#_1adb3999_7ff6_43eb_b04f_f4de391941dd
is encoded by: hsa:285973
type: Species
initial amount: NaN
constant: false
is: Q674R7
name: ATG9B
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_7472e94a_0c68_4f16_b3da_351ec284c680
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:F23536
type: Species
name: _F23536_1_m
has only substance units: false
boundary condition: true

metaM hpyr c
initial amount: NaN
is: CHEBI:17180
name: 3-hydroxypyruvate
boundary condition: false
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
initial concentration: 1.0
is: HMDB01352

metaM ksi pre15 g
constant: false
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 15
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053

metaR S6T16g
modifier: MODEL1310110041#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
is: SBO:0000176
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000

metaR GUACYC
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/4.6.1.2
product: MODEL1310110041#
name: guanylate cyclase

metaM 5mthf e
is: CHEBI:3729
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
constant: false
is: HMDB01396
boundary condition: false
is: C00440
type: Species
is: SBO:0000247
name: 5-Methyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110041#_466cfa39_bc44_43a0_9b82_8efd3dc79074
constant: false
initial amount: NaN
boundary condition: true
name: ACAA1
has only substance units: false
is encoded by: hsa:30
type: Species
initial concentration: NaN
is: Q96CA6
is: SBO:0000252

metaR CYTK2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_f9b2d0fd_bde6_4584_a3e0_be52ce298155
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q02252
boundary condition: true
name: ALDH6A1
is encoded by: hsa:4329
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_23d94952_4d7f_4b09_af0a_6ad3c63a7e1e
name: ACOX1
is: SBO:0000252
initial amount: NaN
is: B4DK61
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:51

metaR r0474
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM dcmp n
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
has only substance units: false
is: HMDB01202
name: dCMP(2-)

metaR r0587
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110041#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
product: MODEL1310110041#
is: SBO:0000176

metaR XOLTRI27tc
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
fast: false
name: 27 trihydroxy cholesterol transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110041#
is: SBO:0000185

metaR BTNDe
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000269
product: MODEL1310110041#
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110041#
name: biotinidase (biotin), extracellular
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110041#

metaR SMS
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
name: Sphingomyelin synthase (homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.27
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
fast: false

metaM ura c
is: SBO:0000247
is: C00106
is: HMDB00300
initial amount: NaN
is: CHEBI:17568
constant: false
name: Uracil
boundary condition: false
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial concentration: 1.0
has only substance units: false

metaR ORNALArBATtc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM asn L c
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
is: SBO:0000247
name: L-asparagine
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17196

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185

metaR DNDPt11m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000269
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
name: dADP transport via dGDP antiport

http://identifiers.org/biomodels.db/MODEL1310110041#_e9965a6b_87e4_4c85_8a2a_2606203a2fc8
initial concentration: NaN
name: PYCR2
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: Q96C36
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29920

metaM nrpphr c
initial concentration: 1.0
is: CHEBI:33569
constant: false
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
is: SBO:0000247
name: Norepinephrine
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a42a65c5_4dae_412d_a383_3f9c25fc73e0
constant: false
is encoded by: hsa:AI656480
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _AI656480_1_m
initial amount: NaN
type: Species
is: SBO:0000252

metaM 6dhf l
name: hexaglutamyl folate (DHF)
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06563
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_289baa20_b34c_45e0_a030_ca450d6460d6
has part: P04844
type: Species
is: SBO:0000297
is encoded by: hsa:6184
name: DAD1:DDOST:RPN1:RPN2
initial amount: NaN
has part: P04843
initial concentration: NaN
has part: P39656
is encoded by: hsa:1603
has only substance units: false
has part: Q53G02
boundary condition: true
is encoded by: hsa:1650
constant: false
is encoded by: hsa:6185

metaM CE2839 e
type: Species
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: C01936

metaR 34HPPOR
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.27
reversible: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110041#

metaM ksii core2 pre5 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
name: keratan sulfate II biosynthesis, precursor 5
is: C00130

metaM adp c
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: C00008
is: SBO:0000247
is: HMDB01341
name: ADP
is: http://identifiers.org/pubchem.compound/3310
has only substance units: false
is: CHEBI:16761

metaM glx x
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00119
name: glyoxylate
is: SBO:0000247
type: Species
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
fast: false
reversible: true
product: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#

metaR B3GNT32g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaM dump c
initial concentration: 1.0
is: CHEBI:246422
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
type: Species
is: C00365
initial amount: NaN
name: dUMP
boundary condition: false
is: HMDB01409

metaR r2357
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_79f72198_470b_4b6a_9172_5df14d579197
boundary condition: true
initial amount: NaN
constant: false
name: ST3GAL2
is: SBO:0000252
is encoded by: hsa:6483
type: Species
is: Q16842
has only substance units: false
initial concentration: NaN

metaR GALASE14ly
name: beta-galactosidase, lysosomal
type: Reaction
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR DM ethamp r
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM 3oddcoa m
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
name: 3-Oxododecanoyl-CoA
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03937
is: SBO:0000247
is: CHEBI:27868
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8ab21104_6ed8_4f3b_bcc5_6b83a7f86e0d
constant: false
type: Species
name: PDE9A
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
initial amount: NaN

metaM CE5786 e
has only substance units: false
is: CHEBI:27485
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB02710
name: kinetensin
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r2142
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
type: Reaction
reversible: true

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_2ab8e11e_6d63_4ec4_bc58_ffa088408840
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2880
boundary condition: true
is: O75715
name: GPX5

http://identifiers.org/biomodels.db/MODEL1310110041#_e89adf35_111c_42ab_aa49_0ba8cda7d224
type: Species
is: Q13825
name: AUH
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:549
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_7b6caabb_86c7_40f3_b792_e2ab633c776c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC10A1
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:6554
is: B2RA41

http://identifiers.org/biomodels.db/MODEL1310110041#_8cf26fa2_33aa_4c4a_bec1_f27afb26c50c
boundary condition: true
initial concentration: NaN
is: Q9H903
constant: false
is: SBO:0000252
type: Species
name: MTHFD2L
is encoded by: hsa:441024
has only substance units: false
initial amount: NaN

metaM 6dhf m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
is: HMDB06563
type: Species
boundary condition: false
constant: false
name: hexaglutamyl folate (DHF)
is: SBO:0000247

metaM citr L c
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:16349
boundary condition: false
initial amount: NaN
is: HMDB00904
has only substance units: false
is: SBO:0000247
name: L-citrulline

metaR FRDPtc
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: lipid, flip-flop intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110041#

metaR r1570
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_d64bc3dc_dc53_4989_97e6_c2c5275bc705
name: ENPP1
has only substance units: false
is encoded by: hsa:5167
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P22413

metaR UMPK3n
is described by: ECO:0000269
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: UMP kinase (UTP),nuclear
type: Reaction
fast: false
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110041#

metaR r2356
fast: false
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110041#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reversible: true
fast: false
product: MODEL1310110041#
is described by: ECO:0000000

metaR r1573
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110041#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

metaR r0842
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110041#
is described by: ECO:0000000
name: Postulated transport reaction
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#

metaM acgam1p c
name: N-Acetyl-D-glucosamine 1-phosphate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
type: Species
is: HMDB01367
constant: false
has only substance units: false
is: CHEBI:7125

metaR XOLTRI27te
reactant: MODEL1310110041#
name: 27 trihydroxy cholesterol transport
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

http://identifiers.org/biomodels.db/MODEL1310110041#_cddfc399_294e_4b75_9bfd_78fe4c3f8e7b
name: CPT1B
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1375
constant: false
has only substance units: false
boundary condition: true
is: Q92523

metaR NDP7g
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.6
fast: false
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000269
name: nucleoside-diphosphatase (UDP), Golgi apparatus
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_25a2e706_60c3_471a_9c41_8b73389ccd33
is: Q9NQ66
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PLCB1
type: Species
boundary condition: true
is encoded by: hsa:23236
constant: false
initial concentration: NaN

metaR RE3627M
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
name: Free diffusion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_e241ece0_d2b5_400a_86d3_f760b76f5173
type: Species
is: Q96NT5
constant: false
initial amount: NaN
is encoded by: hsa:113235
has only substance units: false
boundary condition: true
name: SLC46A1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_e3a2ad26_ccd1_42b9_b454_48df1351e8c4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: E5KSL6
name: DGUOK
constant: false
is encoded by: hsa:1716

metaM coa n
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01423
has only substance units: false
name: coenzyme A(4-)
initial concentration: 1.0
is: CHEBI:57287
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6aeaf8a2_e26f_4157_bc6f_861683265670
is encoded by: hsa:AI761708
type: Species
name: _AI761708_1_m
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR PPA
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
reactant: MODEL1310110041#
name: inorganic diphosphatase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
reversible: false
modifier: MODEL1310110041#
type: Reaction
product: MODEL1310110041#

metaM CE2243 c
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: trans-eicos-2-enoyl-CoA
notes: FORMULA: C41H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h20-21,28-30,34-36,40,51-52H,4-19,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE2243
is: CHEBI:52324
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_b57594d8_33d8_410b_b115_88e354759fce
is: SBO:0000252
type: Species
boundary condition: true
name: PDE9A
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5152
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_317eb777_2a0f_45fe_949d_68a63ddabd5d
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2650
name: GCNT1
constant: false
is: Q02742
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_42098493_9212_496a_bc56_017f7eb4c51c
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9962
constant: false
initial concentration: NaN
name: SLC23A2

metaM nrpphr e
is: HMDB00216
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
name: Norepinephrine
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:33569

metaR A MANASEly
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.24
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: alpha-mannosidase, lysosomal
modifier: MODEL1310110041#

metaM gdpmann c
has only substance units: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
is: HMDB01163
initial amount: NaN
constant: false
is: CHEBI:57527
initial concentration: 1.0
name: GDP-alpha-D-mannose(2-)
type: Species
boundary condition: false

metaM ksi pre5 g
is: SBO:0000247
boundary condition: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
type: Species
name: keratan sulfate I biosynthesis, precursor 5
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
constant: false
initial amount: NaN

metaR APOC LYS BTNP
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110041#
name: proteolysis of apoC-Lys-btn
reactant: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaR NMNS
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
name: NMN synthetase
reversible: false
is: SBO:0000176
fast: false

metaM 3hpp m
type: Species
is: HMDB00700
constant: false
is: CHEBI:16510
boundary condition: false
name: 3-hydroxypropionate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r0841
reversible: true
name: Free diffusion
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.271
modifier: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
type: Reaction

metaR r0475
reactant: MODEL1310110041#
fast: false
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM ile L m
initial concentration: 1.0
constant: false
is: HMDB00172
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
has only substance units: false
name: L-isoleucine
type: Species
boundary condition: false
initial amount: NaN

metaM dolmanp U c
initial amount: NaN
name: Dolichyl phosphate D-mannose, human uterine homolog
type: Species
is: CHEBI:15809
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_805bca60_b37c_462a_a3fa_b05621339022
boundary condition: true
type: Species
initial concentration: NaN
name: GGCT
has only substance units: false
constant: false
is: SBO:0000252
is: B8ZZR8
initial amount: NaN
is encoded by: hsa:79017

metaR ADPtx
name: ADP transporter, peroxisomal
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR PI4PP
type: Reaction
product: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
is: SBO:0000176
name: phosphatidylinositol-4-phosphate 4-phosphatase
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false

metaM coa m
constant: false
boundary condition: false
is: HMDB01423
is: C00010
type: Species
initial concentration: 1.0
is: CHEBI:57287
initial amount: NaN
is: SBO:0000247
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false

metaM 4hpro LT m
initial concentration: 1.0
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
constant: false
type: Species
is: CHEBI:18095
is: SBO:0000247
boundary condition: false
name: trans-4-hydroxy-L-proline
initial amount: NaN
has only substance units: false

metaR r2358
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM HC00822 l
has only substance units: false
type: Species
name: Chitobiose
is: CHEBI:28681
constant: false
initial amount: NaN
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR r0051
type: Reaction
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR GLYBtm
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_ec889f2e_e3a2_48ce_a4c1_f69935a797b4
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:30833
name: NT5C
is: SBO:0000252
is: Q8TCD5
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_c2e8e51a_b92e_4a1b_bc7c_6870aef94cbe
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:33
name: ACADL
is: P28330
is: SBO:0000252

metaR RE0568C
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: true
fast: false
name: RE0568
notes: GENE_ASSOCIATION: (9045.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_dbfcfccc_2ad8_4447_9425_2009f72aeaf2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6785
constant: false
initial concentration: NaN
initial amount: NaN
name: ELOVL4
is: Q9GZR5
type: Species
boundary condition: true

metaM core3 g
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: Core 3
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16250

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
fast: false
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true

metaM 3mob m
is: HMDB00019
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:11851
has only substance units: false
initial concentration: 1.0

metaM gbside hs g
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: globoside
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:18259
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110041#_cc0d9688_8897_467f_b81e_9b0247e90bee
name: NT5C1B
constant: false
is: Q96P26
boundary condition: true
initial amount: NaN
is encoded by: hsa:93034
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4e5c4b14_d905_42b7_9f0d_fda7adc4b6aa
is encoded by: hsa:622
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: BDH1
type: Species
is: SBO:0000252
constant: false

metaM ksi pre4 g
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: C00130
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 4
is: HMDB00175
is: CHEBI:58053

metaR r0735
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176

metaR r1299
is described by: ECO:0000000
name: Vesicular transport
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#

metaM L2aadp m
name: L-2-aminoadipate(1-)
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB00510
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR GLUDym
is: SBO:0000176
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
type: Reaction

metaM tag hs c
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
name: triglyceride
is: CHEBI:17855
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false

metaM xol7aone m
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
is: CHEBI:17899

http://identifiers.org/biomodels.db/MODEL1310110041#_3d2be463_dd39_40a6_8fbd_05b0670035e7
type: Species
is: B4DZR2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8854
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: ALDH1A2

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR LYStip
is: SBO:0000185
reactant: MODEL1310110041#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
kinetic law: MODEL1310110041#
name: L-lysine transport, peroxisomal (irreversible)
product: MODEL1310110041#
fast: false
type: Reaction

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
has only substance units: false
initial amount: NaN
is: HMDB00637
type: Species
is: CHEBI:36252
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_86dc053d_678b_4961_9e21_3ab2c63d62bd
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:7263
is: Q16762
name: TST

metaM coa c
is: SBO:0000247
is: C00010
constant: false
initial amount: NaN
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
has only substance units: false
is: HMDB01423
initial concentration: 1.0
is: CHEBI:3312
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9354f14d_7df1_469f_8a6e_71c4747c815a
is encoded by: hsa:686
type: Species
name: BTD
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: P43251

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR KYNATESYN
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
type: Reaction
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM dcmp c
is: CHEBI:57566
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: HMDB01202
is: C00239
has only substance units: false

metaM 2kmb c
type: Species
notes: FORMULA: C5H7O3S CHARGE: -1
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01553
is: CHEBI:16723
constant: false
name: 2-keto-4-methylthiobutyrate
initial concentration: 1.0

metaR GNDer
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000
reactant: MODEL1310110041#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
product: MODEL1310110041#
fast: false
reversible: false

metaR UDPGLCAter
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
product: MODEL1310110041#
type: Reaction
reversible: true
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000269
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110041#

metaR FAOXC16080m
reactant: MODEL1310110041#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
type: Reaction
product: MODEL1310110041#

metaM cytd m
boundary condition: false
name: cytidine
is: HMDB00089
is: CHEBI:17562
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f44a3cbb_f9db_44dc_8f14_26bb99c9386d
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: _AA419122_1_c
is encoded by: hsa:AA419122
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_31cb9695_a451_4e96_a2fb_ead2ac127d53
initial amount: NaN
boundary condition: true
is encoded by: hsa:8818
is: SBO:0000252
name: DPM2
initial concentration: NaN
constant: false
type: Species
is: O94777
has only substance units: false

metaR HSD17B3r
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.64
product: MODEL1310110041#
reversible: false
name: testicular 17-beta-hydroxysteroid dehydrogenase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3293.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:12429500 NOTES:Human kidney cell line used and Km/Vmax quantified
is: SBO:0000176

metaR CHOLESTle
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.1.13
is: SBO:0000176
is described by: ECO:0000134
name: hydrolysis of cholesterol ester by cholesterol esterase
modifier: MODEL1310110041#

metaR r0734
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction

metaM gly m
is: C00037
initial amount: NaN
is: CHEBI:15428
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: Glycine
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_58d4d0b7_c05a_4880_bf68_5b5db8906b40
is encoded by: hsa:8836
is: SBO:0000252
initial amount: NaN
name: GGH
is: Q92820
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR CPPPGO
product: MODEL1310110041#
is: SBO:0000176
fast: false
is described by: ECO:0000304
name: coproporphyrinogen oxidase (O2 required)
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (1371.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.3 Confidence Level: 2 AUTHORS: PMID:8407975 NOTES:r0608, JLR
type: Reaction
reversible: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.3.3
modifier: MODEL1310110041#

metaM cl c
name: Chloride
is: C00115
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
constant: false
is: CHEBI:3966
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR ECOAH9m
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110041#

metaM 3php c
name: 3-phosphonatooxypyruvate(3-)
has only substance units: false
is: CHEBI:18110
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01024
initial amount: NaN
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
initial concentration: 1.0

metaM hdd2coa m
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
is: CHEBI:61526
boundary condition: false
constant: false
is: C05272
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
is: SBO:0000247
is: HMDB03945
type: Species

metaM dha e
has only substance units: false
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone
initial amount: NaN
boundary condition: false
is: HMDB01882
is: CHEBI:16016
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM HC01602 c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: C00234
is: CHEBI:57454
type: Species
name: 10-Formyltetrahydrofolate
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

http://identifiers.org/biomodels.db/MODEL1310110041#_4d74b455_2e63_4b2a_84d5_564e225e60cf
constant: false
initial amount: NaN
has only substance units: false
name: GCDH
is encoded by: hsa:2639
type: Species
is: Q92947
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM ksi deg12 l
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: HMDB00143
boundary condition: false
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 12

metaM thymd m
name: Thymidine
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: HMDB00273
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00214
is: CHEBI:17748
initial amount: NaN

metaM ade c
constant: false
is: C00147
is: HMDB00034
type: Species
initial concentration: 1.0
is: CHEBI:16708
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: Adenine
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR S6TASE10ly
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110041#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
modifier: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_5f8506c9_9856_4e89_bfd7_9ede52ee5c37
is: SBO:0000252
has only substance units: false
is: B3KTV4
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ADSSL1
is encoded by: hsa:122622
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2656f6e5_2c79_4346_8d43_e78271a75a1c
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AKR1A1
is encoded by: hsa:10327
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_d830cba4_9844_423d_824d_986143e4f23f
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: E7EPT3
is encoded by: hsa:501
constant: false
name: ALDH7A1
has only substance units: false

metaR r2141
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000185
reversible: true
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_857c0c5f_b5a8_4a06_95ac_e9d213b1026a
is: Q13613
boundary condition: true
name: MTMR1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:8776
initial amount: NaN

metaM 3pg c
type: Species
boundary condition: false
initial amount: NaN
is: C00197
is: CHEBI:58272
constant: false
is: HMDB00807
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 3-Phospho-D-glycerate
is: http://identifiers.org/pubchem.compound/3497

metaR r0733
product: MODEL1310110041#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110041#_ad233b25_e0fd_44a7_927a_fff92fdb7fcc
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: Q13126
name: MTAP
is encoded by: hsa:4507
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_c6fe9a00_61cb_42f3_abf1_87529f12c3d6
name: SLC4A4
is encoded by: hsa:8671
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: A5JJ20
initial concentration: NaN
is: SBO:0000252
type: Species

metaR ABTD
type: Reaction
product: MODEL1310110041#
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_bd3343ba_5ddf_455b_b337_572762beeb03
is encoded by: hsa:11227
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GALNT5
type: Species
initial concentration: NaN
boundary condition: true
is: A5PKZ1
constant: false

metaM HC01603 c
is: CHEBI:57454
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00234
has only substance units: false
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_323172a6_4a64_4ffb_8a28_3770ebe3695f
is: SBO:0000252
is encoded by: hsa:2194
constant: false
boundary condition: true
is: P49327
initial amount: NaN
initial concentration: NaN
name: FASN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_b2edf265_4035_41d6_b397_8307aef11781
name: NT5C2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P49902
type: Species
is encoded by: hsa:22978
boundary condition: true
is: SBO:0000252
constant: false

metaM ade e
type: Species
is: HMDB00034
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
constant: false
is: CHEBI:16708
initial amount: NaN
is: SBO:0000247
name: adenine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8645c314_825f_44cc_badc_e4411f649e11
is: Q8IV97
constant: false
is encoded by: hsa:8140
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC7A5
is: SBO:0000252
has only substance units: false

metaM ribflv c
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
constant: false
is: HMDB00244
name: Riboflavin
is: CHEBI:3554
is: C00255

metaR B3GNT312g
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reversible: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000254

metaR PYNP2r
is version of: http://identifiers.org/ec-code/2.4.2.3
reactant: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176

metaR r1156
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110041#
type: Reaction

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_b21c0ce8_86bb_48a3_a861_3e144ff87517
name: _286297_1_c
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:286297
constant: false

metaM dudp c
constant: false
name: dUDP
is: CHEBI:60471
boundary condition: false
type: Species
initial amount: NaN
is: C01346
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
is: HMDB01000

http://identifiers.org/biomodels.db/MODEL1310110041#_4c490c11_271e_4421_aba3_33391d03f07b
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: HSD17B10
is encoded by: hsa:3028
is: Q99714
type: Species

metaM cl e
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
is: C00115
is: CHEBI:3966
boundary condition: false
type: Species
name: Chloride
initial concentration: 1.0
is: HMDB00492
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ade60dc2_cf44_4de7_8852_5809d00b7e10
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: B3GALT5
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10317
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_0749953c_881c_4d92_bab3_fe5de9523ec8
initial amount: NaN
has part: B7Z3U6
is: SBO:0000297
is encoded by: hsa:483
is encoded by: hsa:476
type: Species
boundary condition: true
has part: P54709
initial concentration: NaN
has only substance units: false
name: ATP1A1:ATP1B3
constant: false

metaR SPMTDe
fast: false
is described by: ECO:0000134
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110041#
name: SPMTDe
reversible: true
reactant: MODEL1310110041#

metaM pi x
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00973
initial amount: NaN
is: CHEBI:43474
initial concentration: 1.0
type: Species
has only substance units: false

metaR r0584
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
fast: false
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
modifier: MODEL1310110041#
is: SBO:0000176

metaR r2140
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR r0732
type: Reaction
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000

metaR O2tp
reactant: MODEL1310110041#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110041#
name: O2 transport, peroxisomal
product: MODEL1310110041#
fast: false

metaR S6T4g
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
product: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a545ca35_cf78_4574_941c_2b6a03272a2b
is encoded by: hsa:35
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACADS
is: P16219

metaM ppp9 m
boundary condition: false
is: HMDB00241
notes: FORMULA: C34H32N4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00905 EHMN_ABBREVIATION: C02191
initial amount: NaN
name: Protoporphyrin
type: Species
has only substance units: false
is: CHEBI:36159
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM na1 r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:29101
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
name: sodium(1+)
has only substance units: false
constant: false
is: HMDB00588
type: Species
is: SBO:0000247

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM 5dhf l
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: pentaglutamyl folate (DHF)

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110041#
fast: false
type: Reaction
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110041#_b524d621_31c3_441a_adae_a5f166357cb0
name: CMPK1
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51727
is: B2R6S5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_c992b69b_703e_4209_b807_5382f0d25e08
type: Species
initial concentration: NaN
is: P42765
has only substance units: false
is encoded by: hsa:10449
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: ACAA2

metaR r1579
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR r0731
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110041#

metaR O2tm
product: MODEL1310110041#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
name: O2 transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF

metaR r0055
fast: false
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is: SBO:0000176
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
product: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.2.7
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000000

metaR DHCRD1
fast: false
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110041#

metaM 5dhf m
is: HMDB06487
type: Species
boundary condition: false
name: pentaglutamyl folate (DHF)
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110041#_6966aabd_55a5_4f3c_831b_587e72d20682
has only substance units: false
constant: false
boundary condition: true
is: O95822
name: MLYCD
is encoded by: hsa:23417
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1365
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#

metaM gluside hs g
is: CHEBI:18368
constant: false
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_74be4d0c_da54_4054_8b8c_125336847549
boundary condition: true
has only substance units: false
name: PHGDH
initial amount: NaN
is encoded by: hsa:26227
type: Species
initial concentration: NaN
constant: false
is: O43175
is: SBO:0000252

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR GLCter
kinetic law: MODEL1310110041#
fast: false
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
name: glucose transport, endoplasmic reticulum
product: MODEL1310110041#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r1150
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000000

metaR MI4PP
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
name: myo-inositol 4-phosphatase
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25
is: SBO:0000176
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaM trp L c
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
boundary condition: false
name: L-tryptophan
is: HMDB00929
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_159be705_970e_43e4_b2e4_e4aae87e3093
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5464
is: Q15181
initial concentration: NaN
boundary condition: true
name: PPA1
has only substance units: false
constant: false

metaM HC02204 c
initial concentration: 1.0
is: CHEBI:27624
name: prostaglandin-b1
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
constant: false

metaR DNDPt33m
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
is: SBO:0000185
name: dGDP transport via dUDP antiport
type: Reaction
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110041#

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaM alpro m
initial concentration: 1.0
name: S-Aminomethyldihydrolipoylprotein
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16882
type: Species

metaM CE2431 m
boundary condition: false
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
is: C01936
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_fca36cde_878a_4c5a_83d8_86b343b560f0
has only substance units: false
type: Species
is: P30613
boundary condition: true
constant: false
name: PKLR
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5313

metaM 6dhf e
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: HMDB06563
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_560b2eed_6973_444a_8db8_73cb662407e2
is encoded by: hsa:10400
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: PEMT
initial concentration: NaN
is: Q9UBM1

metaR HAS2
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
fast: false
modifier: MODEL1310110041#
name: hyaluronan synthase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD

metaR CYTK2n
name: cytidylate kinase (dCMP),nuclear
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

metaR CYSGLYexR
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reactant: MODEL1310110041#
name: L-cysteine/glycine reversible exchanger
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_398d6567_8045_4bc3_a7ed_ebdf1731d231
is: SBO:0000252
has only substance units: false
type: Species
is: P55916
is encoded by: hsa:7352
initial amount: NaN
name: UCP3
constant: false
initial concentration: NaN
boundary condition: true

metaR r0730
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110041#
reversible: false
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_31b7f45d_045d_435e_9fdb_5c7d87b8165b
is: Q8WUD6
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: CHPT1
is encoded by: hsa:56994
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR O2tn
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000185
name: O2 nuclear transport
kinetic law: MODEL1310110041#

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#

metaR STRDNCt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110041#
reactant: MODEL1310110041#
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110041#
fast: false
reversible: true
is described by: ECO:0000000

metaR RE3006M
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
type: Reaction
name: RE3006

metaM CE5121 m
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57449
initial amount: NaN
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
name: trans-3-decenoyl-CoA
has only substance units: false

metaR DOLPMT U
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
type: Reaction
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
product: MODEL1310110041#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176

metaM triodthy c
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
boundary condition: false
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaM xol7aone r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
constant: false
type: Species
boundary condition: false
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
is: CHEBI:17899
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f3bb6705_b7b4_4172_b006_8c4298bb6966
is encoded by: hsa:AI684467
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AI684467_1_m
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_57b38f76_b4d6_422e_bd27_bfdded171240
type: Species
name: GAMT
is encoded by: hsa:2593
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM no e
constant: false
is: SBO:0000247
name: Nitric oxide
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
initial concentration: 1.0
type: Species
is: C00533
has only substance units: false
is: HMDB03378
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a09411c1_e57b_4935_9103_3c2e36e73e76
has only substance units: false
initial concentration: NaN
name: OCRL
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4952
constant: false
initial amount: NaN

metaR r1364
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_33f2f00f_78bb_4007_9066_f89a183801e2
name: SLC16A2
is encoded by: hsa:6567
is: P36021
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_5b67cc8d_9a12_42c7_9914_8f2936713ef0
boundary condition: true
constant: false
is: SBO:0000252
is: O14561
is encoded by: hsa:4706
name: NDUFAB1
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_b8502b16_85e5_45a8_858b_4f6ced9d3369
boundary condition: true
type: Species
name: COASY
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80347
is: Q13057
constant: false
is: SBO:0000252
initial amount: NaN

metaR RPI
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribose-5-phosphate isomerase
reversible: true
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

metaR PEt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110041#
name: phosphatidylethanolamine transport
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
reactant: MODEL1310110041#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_883957d4_3503_44b7_ad74_641c98c65888
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8654
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: PDE5A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_9f39f592_516c_4ed3_bfbd_61126b98bf63
initial amount: NaN
is: SBO:0000252
name: SLC7A6
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9057
is: Q92536

metaM ksi pre26 g
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 26

metaR RE2677E
kinetic law: MODEL1310110041#
is described by: ECO:0000000
name: RE2677
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton

metaM spc hs c
name: sphingosylphosphorylcholine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_8c5df0aa_f6ab_4abd_b5a8_d3e262c03ad5
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:1718
is: Q15392
has only substance units: false
type: Species
initial amount: NaN
name: DHCR24
is: SBO:0000252

metaR G14T4g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM adp m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
name: ADP
has only substance units: false
is: CHEBI:456216
type: Species
is: HMDB01341
boundary condition: false
initial amount: NaN
is: C00008
constant: false
is: SBO:0000247

metaM glx m
type: Species
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
is: HMDB00119
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:36655
constant: false

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type: Species
boundary condition: true
is: P26572
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: MGAT1
is: SBO:0000252
is encoded by: hsa:4245

http://identifiers.org/biomodels.db/MODEL1310110041#_455510a0_f8ac_44d1_857c_026026d9c141
constant: false
boundary condition: true
name: ALDOB
has only substance units: false
initial concentration: NaN
is: P05062
is: SBO:0000252
is encoded by: hsa:229
initial amount: NaN
type: Species

metaR r0267
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110041#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.9
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_6e192d36_1cc5_41d5_9817_54f4a03ef426
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: B3GNT2
boundary condition: true
initial amount: NaN
is encoded by: hsa:10678

http://identifiers.org/biomodels.db/MODEL1310110041#_c4bcca3a_1720_43fd_9900_377ec2f13de7
initial concentration: NaN
is encoded by: hsa:27068
is: SBO:0000252
boundary condition: true
constant: false
name: PPA2
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_02f1a964_6ce5_480e_b72d_afe98f86374a
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: PECR
is: SBO:0000252
is: Q9BY49
is encoded by: hsa:55825

http://identifiers.org/biomodels.db/MODEL1310110041#_6d574dce_6555_4579_a244_e16a394d57aa
is encoded by: hsa:1633
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DCK
boundary condition: true
is: P27707
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_40d94df5_4ac4_4788_97ec_b4c38b06263d
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: GSTZ1
is encoded by: hsa:2954
has only substance units: false
is: SBO:0000252

metaM trp L e
initial concentration: 1.0
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
boundary condition: false
name: L-tryptophan
is: SBO:0000247
is: HMDB00929
constant: false
initial amount: NaN
has only substance units: false

metaM HC01376 m
constant: false
type: Species
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:28692
name: S-(2-Methylbutanoyl)-dihydrolipoamide

http://identifiers.org/biomodels.db/MODEL1310110041#_de8a6309_1ed7_4e8c_8c69_2dede91cfee3
type: Species
has only substance units: false
is: Q9Y6M9
is encoded by: hsa:4715
name: NDUFB9
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM mmcoa S m
is: CHEBI:57327
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
is: HMDB02310
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: (S)-methylmalonyl-CoA(5-)

metaR MAN6PI
is described by: ECO:0000304
reactant: MODEL1310110041#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.8
reversible: true
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110041#
type: Reaction
name: mannose-6-phosphate isomerase
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

metaR r0580
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
fast: false

metaR RE3421R
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: RE3421
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_b366124a_fb57_40ed_899b_32028a9c91ae
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: Q16760
is encoded by: hsa:8527
name: DGKD
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM triodthy e
is: CHEBI:18258
is: SBO:0000247
is: HMDB00265
type: Species
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
boundary condition: false
initial amount: NaN
constant: false

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
name: RE3272
type: Reaction

metaR r2519
reversible: true
is: SBO:0000185
name: Utilized transport
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

metaR r0268
is described by: ECO:0000000
modifier: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
product: MODEL1310110041#

metaM ksii core4 deg1 l
constant: false
initial concentration: 1.0
is: CHEBI:57737
initial amount: NaN
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 1
is: HMDB00868
type: Species
boundary condition: false
is: SBO:0000247

metaM adp n
is: CHEBI:456216
type: Species
name: ADP(3-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01341
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaM dgchol e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
is: CHEBI:36252
name: glycochenodeoxycholate
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_71de9b51_4501_47ca_a082_3fb8efef0c6e
is: Q9NY65
is: SBO:0000252
name: EHHADH
constant: false
initial amount: NaN
is encoded by: hsa:1962
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_2df77a13_b5da_4caa_8cd3_6c49b046f7ef
name: ACSL6
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: B2RB13
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23305
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_92495599_877c_4bf7_9da9_9b43f0e1596a
is: P40879
initial amount: NaN
name: SLC26A3
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1811
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5cd80122_b2bc_43ca_8c39_e0ceed4a6ae9
has only substance units: false
is encoded by: hsa:AA081045
constant: false
is: SBO:0000252
name: _AA081045_1_c
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaR r1298
product: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
kinetic law: MODEL1310110041#
name: Vesicular transport

metaM no c
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16480
type: Species
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: HMDB03378
name: Nitric oxide
boundary condition: false

metaM ksi pre23 g
name: keratan sulfate I biosynthesis, precursor 23
is: CHEBI:28067
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false

metaM fmn e
type: Species
initial amount: NaN
is: CHEBI:58210
notes: FORMULA: C17H19N4O9P CHARGE: -2
has only substance units: false
is: HMDB01520
is: C00061
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: FMN

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM g1m8masn r
type: Species
notes: FORMULA: C76H127N2O60X CHARGE: 0
has only substance units: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C05875

metaR DM sTn antigen g
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM sTn antigen(g)
type: Reaction

metaR EBASTINEOHte
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
name: xenobiotic transport
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
product: MODEL1310110041#
fast: false

metaR r0963
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
name: Facilitated diffusion
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is: SBO:0000185
reactant: MODEL1310110041#

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM gly e
is: SBO:0000247
is: C00037
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
name: Glycine
boundary condition: false
is: HMDB00123

http://identifiers.org/biomodels.db/MODEL1310110041#_36120d28_0e5a_4c72_bd87_e89895ed8ee8
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:D29675
name: _D29675_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_482dd3d0_89cc_448a_9912_e31eba1d232e
is: Q5JT09
initial concentration: NaN
boundary condition: true
name: UCK1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:83549
is: SBO:0000252
initial amount: NaN

metaM cytd e
constant: false
type: Species
initial concentration: 1.0
is: HMDB00089
is: C00475
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_3cd9c61d_241c_459a_9b74_5a8aeef05df9
is: Q02846
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:3000
is: SBO:0000252
name: GUCY2D

http://identifiers.org/biomodels.db/MODEL1310110041#_3b4febcb_53ae_42af_9be3_a14a895d1d03
boundary condition: true
name: NDUFC2
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4718
is: Q549M5
has only substance units: false
constant: false

metaM C05965 e
is: CHEBI:57444
is: SBO:0000247
is: HMDB04243
name: 12(S)-HPETE(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false

metaR CO2t
name: CO2 transporter via diffusion
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
kinetic law: MODEL1310110041#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f24e9d81_f810_4c78_8fa7_ce0af625204b
has only substance units: false
is encoded by: hsa:171425
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: CLYBL

http://identifiers.org/biomodels.db/MODEL1310110041#_e8335396_f6fd_49c6_823f_01c50f4ae42d
type: Species
is: A8K3J4
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:23632
initial amount: NaN
name: CA14

metaM L2aadp c
initial amount: NaN
name: L-2-aminoadipate(1-)
is: CHEBI:58672
boundary condition: false
is: HMDB00510
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR PPAn
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
name: inorganic diphosphatase, nuclear
reversible: false
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_cd39c322_1534_4395_96da_53ef0a86a962
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:291
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: P12235
name: SLC25A4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_83e6e788_3f70_4aa8_9fd7_6cfded791239
name: GPX6
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:257202
initial amount: NaN
has only substance units: false
is: P59796

metaM m4masn g
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C46H77N2O35X CHARGE: 0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05881

metaM HC01444 e
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15754
name: Galactosylglycerol
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247

metaR RE0926E
name: RE0926
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110041#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_100d3a00_3d46_4592_9f23_001c9548d313
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5313
is: P30613
has only substance units: false
name: PKLR
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaR AMETt2m
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110041#

metaR BTNt4i
reversible: false
type: Reaction
fast: false
is: SBO:0000185
name: Biotin uptake (antiport)
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_466d3924_4ec0_4542_bad4_37e233dcbf96
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q9GZX3
boundary condition: true
name: CHST6
is encoded by: hsa:4166

metaR PAIL HStn
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: phosphatidylinositol nuclear transport (diffusion)
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110041#

metaR RE1534M
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1534
type: Reaction
reversible: true

metaR PNTOte
name: Transport of (R)-Pantothenate
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000134
fast: false

metaM orot e
constant: false
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:30839
is: HMDB00226
name: orotate

http://identifiers.org/biomodels.db/MODEL1310110041#_cd0f647f_c657_402a_98a6_c02b2393b3e4
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PNP
is: P00491
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4860
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_27e73571_4a1e_4bac_b569_833178105435
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3632
name: INPP5A
has only substance units: false
constant: false
boundary condition: true
is: Q14642

metaM apoC Lys btn m
is: C05552
initial amount: NaN
boundary condition: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
initial concentration: 1.0
is: HMDB03134
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886

metaR GLYBt4 2 r
name: Betaine transport (sodium symport) (2:1)
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is: SBO:0000185
modifier: MODEL1310110041#
is described by: ECO:0000269
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR r0330
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reversible: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_1035beef_f338_438c_a26d_f70d49e9fd93
initial concentration: NaN
boundary condition: true
type: Species
name: GUCY2C
is: P25092
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2984
initial amount: NaN

metaM ksi deg29 l
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
name: keratan sulfate I, degradation product 29
initial concentration: 1.0
boundary condition: false

metaM gly c
is: HMDB00123
initial concentration: 1.0
is: SBO:0000247
is: C00037
has only substance units: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
constant: false
name: Glycine
is: CHEBI:3339
boundary condition: false

metaR ADNK1m
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#
reversible: false
name: adenosine kinase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR BILIRUBtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110041#
fast: false
reversible: true
is: SBO:0000185
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction

metaR ITCOAL1m
reactant: MODEL1310110041#
reversible: true
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_abbebdf6_5c3d_4d49_9694_b3e58933783e
constant: false
name: AK1
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:203
is: SBO:0000252
initial concentration: NaN
is: P00568
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_e77a2884_3364_4da5_9b01_a40e335a8054
name: PC
type: Species
is encoded by: hsa:5091
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaM 3dhguln c
has only substance units: false
name: 3-dehydro-L-gulonate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: SBO:0000247
is: CHEBI:57655
is: HMDB06334
initial amount: NaN
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5d47d7a5_59b5_4562_b2f5_b991272c7330
initial concentration: NaN
is: SBO:0000252
name: ADSL
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:158
type: Species

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_717523fb_52ce_4498_b8a4_3f27fd05766b
has only substance units: false
name: AOC2
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:314
constant: false
is: SBO:0000252
boundary condition: true
is: O75106

metaR 10FTHFtm
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR r1702
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110041#
reactant: MODEL1310110041#

metaR FRDPtr
fast: false
type: Reaction
product: MODEL1310110041#
name: lipid, flip-flop intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_adfdbeef_e0c6_42b2_86f3_3342baf3dd7f
is: Q6LEN6
initial amount: NaN
constant: false
boundary condition: true
name: CHAT
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110041#_d36c9caf_87fe_4602_b791_9ef872d672a3
is: Q9BYV1
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: AGXT2
is encoded by: hsa:64902
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1375
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110041#
fast: false
reversible: false
reactant: MODEL1310110041#
name: Transport reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_5d22ec99_7383_4d6a_8afb_b45a27f6ca2c
is: SBO:0000252
constant: false
has only substance units: false
is: P00338
initial amount: NaN
type: Species
is encoded by: hsa:3939
boundary condition: true
name: LDHA
initial concentration: NaN

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_27add776_035c_4584_8d86_44bbdfb5703c
name: _C7orf24_1_m
constant: false
is encoded by: hsa:C7orf24
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_b72ecab1_8a3d_4d5f_b03d_77370fa904bb
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:22305
name: _22305_1_c
constant: false

metaR PItx
name: Phosphate transporter, peroxisome
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110041#
is: SBO:0000185

metaM orot c
is: CHEBI:30839
is: C00295
is: HMDB00226
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Orotate
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a468bb0f_01cb_44ef_a840_c04646e0b993
is encoded by: hsa:93034
boundary condition: true
is: B3KUK6
constant: false
name: NT5C1B
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_dc70ff9b_8735_4df8_b057_1366ea1ca995
boundary condition: true
is encoded by: hsa:50
type: Species
is: Q99798
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: ACO2

http://identifiers.org/biomodels.db/MODEL1310110041#_1aa7445c_4502_41c5_99d5_b8dde9bac842
is: SBO:0000252
is: Q9UEF7
boundary condition: true
is encoded by: hsa:9365
type: Species
initial amount: NaN
name: KL
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ad3ae1c8_fb1d_4b26_815c_9cd1ee56eef2
is: E9PHN8
is encoded by: hsa:9843
boundary condition: true
name: HEPH
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_2d9e6aef_a2ea_4887_826c_b72cfa8283cf
is encoded by: hsa:9167
type: Species
initial concentration: NaN
name: COX7A2L
has only substance units: false
constant: false
is: Q6FGA0
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_685e3f3e_9568_4fdc_bb30_14dd9d9b56d8
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: IDH2
is: P48735
is encoded by: hsa:3418

http://identifiers.org/biomodels.db/MODEL1310110041#_b75fbdfd_a468_4df3_a353_7fb8aed8368d
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:66002
name: CYP4F12
is: Q9HCS2
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaM 5dhf e
initial concentration: 1.0
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
boundary condition: false
has only substance units: false
name: pentaglutamyl folate (DHF)
is: HMDB06487
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM pail hs n
boundary condition: false
type: Species
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194

http://identifiers.org/biomodels.db/MODEL1310110041#_d503212f_6483_4f11_bdf2_3eba98cb20cb
constant: false
is: SBO:0000252
name: UCK2
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: Q9BZX2
is encoded by: hsa:7371

http://identifiers.org/biomodels.db/MODEL1310110041#_2bab978d_636b_4337_a161_072e33a8a19c
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CPT1C
is encoded by: hsa:126129
is: Q8TCG5
initial amount: NaN
type: Species
initial concentration: NaN

metaR B3GNT51g
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c378fbb4_69f1_4d49_9754_77652f76bf2a
has only substance units: false
initial amount: NaN
is: P00374
boundary condition: true
constant: false
is encoded by: hsa:1719
type: Species
is: SBO:0000252
initial concentration: NaN
name: DHFR

http://identifiers.org/biomodels.db/MODEL1310110041#_a3c56e4f_d0ec_44a0_b315_8f5826e72a27
initial concentration: NaN
is: SBO:0000252
is: O94788
initial amount: NaN
boundary condition: true
name: ALDH1A2
type: Species
is encoded by: hsa:8854
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9e3955bd_0627_44e7_8bf4_92a950db9aed
is: P43353
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ALDH3B1
constant: false
is encoded by: hsa:221
boundary condition: true
type: Species
has only substance units: false

metaM 4mptnl c
is: HMDB01318
initial concentration: 1.0
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:17998
name: 4-methylpentanal
has only substance units: false
is: SBO:0000247

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_5a6ea57c_f825_4074_a33c_664a4cfee0d8
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:622
constant: false
has only substance units: false
initial amount: NaN
name: BDH1

metaR r1147
kinetic law: MODEL1310110041#
reversible: true
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM mal L e
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: (S)-malate(2-)
constant: false
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
is: HMDB00156

http://identifiers.org/biomodels.db/MODEL1310110041#_43fbddd6_1d0a_48d0_89fd_e9dd5a1845b5
has part: B7Z2T0
initial amount: NaN
has part: A3KLL5
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000297
is encoded by: hsa:481
is encoded by: hsa:478
name: ATP1A3:ATP1B1
has only substance units: false

metaM taur x
is: HMDB00251
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:15891
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: taurine

http://identifiers.org/biomodels.db/MODEL1310110041#_1dee2560_2988_448b_b280_9392c7ed6c2d
initial amount: NaN
is: SBO:0000252
is: Q6ZMR3
boundary condition: true
has only substance units: false
is encoded by: hsa:160287
type: Species
name: LDHAL6A
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_032c7d6a_f4fa_4f4e_a597_b84a19957f36
is: SBO:0000297
has only substance units: false
initial amount: NaN
is encoded by: hsa:8801
constant: false
is encoded by: hsa:8802
initial concentration: NaN
name: SUCLG2:SUCLG1
has part: P53597
boundary condition: true
has part: Q96I99
type: Species

metaM cdpdag hs c
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
has only substance units: false
is: CHEBI:58332
name: CDP-diacylglycerol(2-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR PSERT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.52
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
name: phosphoserine transaminase
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_3c58b524_4637_4679_abe9_1553613d5d28
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: MYO5B
type: Species
is encoded by: hsa:4645
is: Q9H6Y6
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_0d5f73f7_31a5_44e9_abd0_939ef1363a4a
is encoded by: hsa:H45672
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: _H45672_1_m
has only substance units: false
initial concentration: NaN

metaM fald c
is: SBO:0000247
is: CHEBI:16842
initial concentration: 1.0
name: formaldehyde
initial amount: NaN
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426
boundary condition: false
constant: false
type: Species

metaM HC01408 m
boundary condition: false
type: Species
name: 3-Oxohexanoyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:27648
has only substance units: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial concentration: 1.0
initial amount: NaN

metaR r0961
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_08df872c_aa04_43f2_8947_c00f6c5e5695
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:27068
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: PPA2

metaM mi134p c
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58414
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial amount: NaN
is: HMDB01143
constant: false
is: SBO:0000247
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_125bca76_a9c0_4360_b7f9_e9db46ab0338
has only substance units: false
initial concentration: NaN
is: Q8N142
type: Species
is encoded by: hsa:122622
name: ADSSL1
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR r2511
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110041#_214d72d9_2783_4ba5_8a74_3f23864f083d
is: P08842
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: STS
type: Species
is encoded by: hsa:412

metaM mi14p c
has only substance units: false
is: HMDB00968
boundary condition: false
type: Species
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_45018d50_1f56_4fa0_849f_f1a7ce2be5a8
initial amount: NaN
type: Species
is encoded by: hsa:1376
name: CPT2
constant: false
initial concentration: NaN
is: P23786
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5608948f_551d_4e39_880f_9252db7c245b
is encoded by: hsa:6530
is: SBO:0000252
boundary condition: true
name: SLC6A2
type: Species
constant: false
initial concentration: NaN
is: Q96KH8
has only substance units: false
initial amount: NaN

metaR DGULND
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110041#
name: dehydro-L-gulonate decarboxylase
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR RE3346C
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reversible: true
name: RE3346
product: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR FMNAT
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.7.2
modifier: MODEL1310110041#
is: SBO:0000176
type: Reaction
name: FMN adenylyltransferase
reversible: false
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y

metaM CE2418 m
constant: false
is: CHEBI:28387
is: SBO:0000247
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
initial amount: NaN
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110041#_53ca89fe_5721_4098_b97d_377df426ed07
is: SBO:0000252
constant: false
is: P33402
type: Species
name: GUCY1A2
boundary condition: true
initial amount: NaN
is encoded by: hsa:2977
initial concentration: NaN
has only substance units: false

metaM C05280 m
is: CHEBI:28002
has only substance units: false
is: HMDB03952
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280

metaM succoa m
name: Succinyl-CoA
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57292
boundary condition: false
constant: false

metaR MCCCrm
type: Reaction
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110041#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.4.1.4

http://identifiers.org/biomodels.db/MODEL1310110041#_6fa11077_5fb5_48f9_a41f_7f4b3c8d9fb5
initial concentration: NaN
is: E7ET30
constant: false
is: SBO:0000252
name: AK3
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:50808
has only substance units: false

metaR r0960
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reactant: MODEL1310110041#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaM 4mptnl e
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN
boundary condition: false
is: CHEBI:17998
is: SBO:0000247
name: 4-methylpentanal
is: HMDB01318

metaR PPAm
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
name: inorganic diphosphatase
fast: false
is: SBO:0000176

metaR GALASE17ly
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false

metaM mal L c
type: Species
initial amount: NaN
is: HMDB00156
initial concentration: 1.0
constant: false
boundary condition: false
name: (S)-malate(2-)
has only substance units: false
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146

metaR DM atp c
fast: false
reactant: MODEL1310110041#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
name: DM_atp(c)
is described by: ECO:0000134

metaM trdrd c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:15967
type: Species
boundary condition: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
name: Reduced thioredoxin
is: C00342

metaR NACHEXA14ly
fast: false
reversible: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_f580ddd8_33a7_4e88_a59f_88b14a7a7bdf
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: BLVRA
boundary condition: true
is: P53004
is encoded by: hsa:644
constant: false

metaR ASCBt4
reversible: true
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
product: MODEL1310110041#
is: SBO:0000185
fast: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: L-ascorbate transport via proton symport
kinetic law: MODEL1310110041#
is described by: ECO:0000269
type: Reaction

metaM CE5117 m
constant: false
initial amount: NaN
is: CHEBI:12947
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_595df369_3fbd_4c57_ba85_587e36544ced
constant: false
name: B3GNT6
is: A8K9Q8
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:192134
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM retinal cis 13 r
type: Species
has only substance units: false
is: CHEBI:45487
initial concentration: 1.0
boundary condition: false
constant: false
name: 13-cis-retinal
is: SBO:0000247
initial amount: NaN
is: HMDB06220
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589

http://identifiers.org/biomodels.db/MODEL1310110041#_15ef1120_219e_4664_8ec7_defe05455b74
is: P04745
type: Species
initial concentration: NaN
is encoded by: hsa:278
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: AMY1C

metaR SGPL12r
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
name: Sphingosine-1-phosphate lyase
fast: false
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR CYTK8
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP)

metaR SERGLYexR
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
fast: false
kinetic law: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
name: L-Serine/Glycine reversible exchange
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_27c048fd_55a6_4c6c_8bd1_6560f216d938
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10637
is: O75610
is: SBO:0000252
type: Species
constant: false
name: LEFTY1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ea9173c6_aedd_427f_958b_3e48a2efb63d
is: A8K5Z0
has only substance units: false
name: B4GALT3
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8703
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR MALTSULtm
reversible: true
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: Malate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#

metaR r1429
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
fast: false
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110041#_a825d160_77c9_4816_a9c6_f142d80c7880
is: P22352
is encoded by: hsa:2878
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GPX3
boundary condition: true
type: Species

metaR N4Tg
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
reversible: false

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_971ca837_196a_48fb_af80_336ef45adce5
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5372
initial concentration: NaN
type: Species
boundary condition: true
is: A8K003
has only substance units: false
name: PMM1

metaR r2364
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_9052f9ca_c859_4ad8_8734_e7465c2badc1
is: SBO:0000252
initial amount: NaN
name: SDS
constant: false
is: P20132
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10993

metaM dolmanp U r
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15809
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
boundary condition: false
constant: false
name: Dolichyl phosphate D-mannose, human uterine homolog

metaR r2365
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_1ef1629d_a5f4_4dae_bae8_c2274030e5a9
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8760
has only substance units: false
name: CDS2
initial concentration: NaN
type: Species
boundary condition: true
is: O95674

http://identifiers.org/biomodels.db/MODEL1310110041#_f76a6800_c138_451f_a8a0_e9ba8d383bee
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4191
type: Species
name: MDH2
constant: false
boundary condition: true
is: P40926

metaR M1316Mg
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is version of: http://identifiers.org/ec-code/3.2.1.114
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
type: Reaction
reactant: MODEL1310110041#

metaR CYTK9
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
name: cytidylate kinase (CMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110041#
reversible: true

metaM gluala e
initial concentration: 1.0
constant: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
initial amount: NaN
has only substance units: false
type: Species
name: 5-L-Glutamyl-L-alanine
boundary condition: false
is: http://identifiers.org/pubchem.compound/6503
is: C03740
is: HMDB06248
is: SBO:0000247

metaM 2obut c
is: C00109
initial amount: NaN
constant: false
is: HMDB00005
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16763
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-Oxobutanoate
type: Species
has only substance units: false

metaM CE1944 c
has only substance units: false
constant: false
is: CHEBI:36781
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 1-pyrrolinium

http://identifiers.org/biomodels.db/MODEL1310110041#_301e10d1_3e9c_4065_81d0_7a4dc7a5f03b
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6392
name: SDHD
is: O14521
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_13d5fc79_d1b3_4a5b_bc7f_ce50a64bedda
boundary condition: true
initial concentration: NaN
is: Q9BYC5
is encoded by: hsa:2530
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: FUT8

metaM s2l2fn2m2masn e
name: PA6
is: CHEBI:3554
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: C00255
is: HMDB00244
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaM glx c
is: CHEBI:36655
boundary condition: false
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00119
constant: false
is: SBO:0000247
name: glyoxylate

metaM sphings c
initial amount: NaN
is: CHEBI:57756
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species
constant: false
boundary condition: false
name: sphingosine(1+)
is: HMDB00252
has only substance units: false

metaR SPHK21c
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.91
name: sphingosine kinase 2
reversible: false
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_725a486c_9998_48fd_b024_4a28a1e35dba
boundary condition: true
type: Species
is encoded by: hsa:6575
has only substance units: false
name: SLC20A2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: B2RBR4
constant: false

metaM na1 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:4541
constant: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: C01330
name: Sodium
is: HMDB00588
boundary condition: false
type: Species

metaR r1640
type: Reaction
fast: false
product: MODEL1310110041#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1580
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_81517fc4_4447_44c8_ab4e_b6fdcf09f44a
initial concentration: NaN
constant: false
name: NDUFS8
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O00217
boundary condition: true
is encoded by: hsa:4728
type: Species

metaR RE2998M
reversible: false
name: RE2998
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176

metaR FAOXC101C8m
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaR PAFH
reversible: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.47
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110041#
name: Platelet-activating factor acetylhydrolase

metaR O2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110041#
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
type: Reaction
product: MODEL1310110041#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_419f7cf3_0c17_4452_b0d3_4a269279d254
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is: P21439
initial amount: NaN
boundary condition: true
is encoded by: hsa:5244
initial concentration: NaN
name: ABCB4

http://identifiers.org/biomodels.db/MODEL1310110041#_58e040b1_5726_43c7_9a2f_37c4d063f17f
is: P36551
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1371
name: CPOX

metaR RE2626C
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
reversible: true
product: MODEL1310110041#
name: RE2626
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
type: Reaction

metaR UMPK2n
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: UMP kinase (CTP),nuclear
modifier: MODEL1310110041#
is described by: ECO:0000269
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
fast: false
type: Reaction

metaM ha pre1 l
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
constant: false
boundary condition: false
is: CHEBI:16126
initial concentration: 1.0
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
type: Species

metaM n2m2nmasn l
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR RE3381E
modifier: MODEL1310110041#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
name: RE3381
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
type: Reaction

metaM acnam l
has only substance units: false
is: CHEBI:35418
name: N-acetylneuraminate
initial concentration: 1.0
type: Species
is: HMDB00230
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
boundary condition: false
constant: false

metaM coa r
has only substance units: false
is: CHEBI:57287
name: Coenzyme A
is: HMDB01423
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: C00010
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4921f8f0_7d4f_4376_8c10_2abfc864d5aa
type: Species
initial amount: NaN
constant: false
name: SLC7A3
boundary condition: true
is encoded by: hsa:84889
is: Q8WY07
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR MEOHt2
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110041#
name: Methanol diffusion
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_45b961a4_5d31_4c55_8cd6_c3c700870c59
has only substance units: false
type: Species
initial concentration: NaN
name: SLC5A12
constant: false
is: Q1EHB4
is encoded by: hsa:159963
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR AKR1C1
name: aldo-keto reductase family 1, member C1 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is version of: http://identifiers.org/ec-code/1.3.1.20
is described by: ECO:0000269
fast: false
reversible: false
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (1645.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.1.20 Confidence Level: 4 AUTHORS: PMID:8486699 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110041#_f348bca6_c348_48da_89e2_4ba665a0c7aa
is encoded by: hsa:125
has only substance units: false
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
name: ADH1A:ADH1B
boundary condition: true
is encoded by: hsa:124
constant: false
type: Species
has part: P00325
has part: P07327

metaR r1641
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110041#

metaR r1630
product: MODEL1310110041#
fast: false
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110041#_15fcb40e_3618_489e_9cc6_902dcc176736
initial amount: NaN
is encoded by: hsa:10558
name: SPTLC1
is: O15269
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR GALASE5ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110041#
product: MODEL1310110041#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_d348fb69_a3b6_4bd2_af0e_4d51906dc3ce
boundary condition: true
initial concentration: NaN
is encoded by: hsa:BE966236
has only substance units: false
type: Species
initial amount: NaN
name: _BE966236_1_c
is: SBO:0000252
constant: false

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction

metaR r2367
product: MODEL1310110041#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false

metaM 7thf e
notes: FORMULA: C49H57N13O24 CHARGE: -8
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06559
has only substance units: false
is: SBO:0000247
name: heptaglutamyl folate (THF)
constant: false
initial concentration: 1.0

metaM ksii core2 deg8 l
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 8
is: CHEBI:12936
notes: FORMULA: C36H60N3O25X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110041#_23486a37_d4e2_4416_a340_bcdd181ca438
initial amount: NaN
initial concentration: NaN
name: GCDH
boundary condition: true
is encoded by: hsa:2639
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaM ctp e
boundary condition: false
name: CTP(4-)
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
has only substance units: false

metaM ura e
initial concentration: 1.0
is: HMDB00300
has only substance units: false
is: CHEBI:17568
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
constant: false
name: uracil

http://identifiers.org/biomodels.db/MODEL1310110041#_2732e32f_126c_4473_89ae_e48908fd3913
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AI620219_1_c
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI620219

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR r0339
reversible: false
reactant: MODEL1310110041#
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false

metaM gar c
name: N1-(5-Phospho-D-ribosyl)glycinamide
has only substance units: false
is: SBO:0000247
is: CHEBI:58457
is: HMDB02022
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C03838

metaR MDHm
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
name: malate dehydrogenase, mitochondrial
is described by: ECO:0000134
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
modifier: MODEL1310110041#
reactant: MODEL1310110041#

metaR r1642
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR CYTK4
type: Reaction
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110041#
name: cytidylate kinase (dCMP)(GTP)
reversible: true

metaM HC02206 e
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
initial concentration: 1.0
type: Species
name: prostaglandin C1(1-)
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaM retinal cis 9 c
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01358
constant: false
initial concentration: 1.0
name: all-trans-retinal
is: CHEBI:17898
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR UMPK2
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaR BTNDm
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
name: biotinidase (biotin), mitochondrial
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1bf806dc_66d9_46e2_9cf2_7a704ad4910c
type: Species
name: CLYBL
is: Q8N0X4
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:171425

metaM cdpdag hs m
has only substance units: false
is: CHEBI:58332
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: CDP-diacylglycerol(2-)

metaR r1643
reactant: MODEL1310110041#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_fc3e4beb_9c15_4162_ad1c_a1ae26dd8e2e
is: SBO:0000252
is encoded by: hsa:8560
has only substance units: false
name: DEGS1
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR r2360
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR RE0915E
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
name: RE0915
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM 5oxpro e
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57606
initial amount: NaN
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
constant: false
is: SBO:0000247
is: HMDB00267
initial concentration: 1.0

metaR r1632
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110041#

metaR r1987
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: false
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_6c38f9e5_ab61_49a2_afa2_8b957e210cc2
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:137872
boundary condition: true
name: ADHFE1
is: Q8IWW8
is: SBO:0000252
initial concentration: NaN

metaM coa x
is: HMDB01423
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
initial concentration: 1.0
type: Species
boundary condition: false
is: C00010
constant: false
is: SBO:0000247
name: Coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110041#_c7f0dc84_0bbc_4739_bb23_a0c29df582fb
is: O00483
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4697
name: NDUFA4
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r1705
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false

metaR CYTK5
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110041#
name: cytidylate kinase (dCMP)
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#

metaM mag hs e
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false
is: HMDB03073
is: CHEBI:32391
initial concentration: 1.0
boundary condition: false
type: Species
name: monoacylglycerol 2

metaR PItn
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
name: phosphate transport, nuclear
reactant: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110041#
fast: false

metaM ctp c
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0
is: SBO:0000247
name: CTP
constant: false
is: CHEBI:37563
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB00082
is: C00063

metaR MMSAD3m
is version of: http://identifiers.org/ec-code/1.2.1.27
reversible: false
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
is described by: ECO:0000269
fast: false
modifier: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
type: Reaction

metaR UMPK3
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110041#
is: SBO:0000176
name: UMP kinase (UTP)
product: MODEL1310110041#

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaM n2m2nmasn e
is: SBO:0000247
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaR PGI
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/5.3.1.9
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
reversible: true
name: glucose-6-phosphate isomerase
kinetic law: MODEL1310110041#
type: Reaction

metaR EBASTINEOHtr
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reactant: MODEL1310110041#
name: xenobiotic transport
is: SBO:0000185

metaR RE1233C
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
name: RE1233
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_b620a348_75c5_4c7f_9d91_36fb5532d1a7
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2686
constant: false
is: SBO:0000252
name: GGT7
initial amount: NaN
type: Species
is: A0PJJ9

metaR r1631
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_4b8fb2bd_1ce4_4742_b4a0_379856f6cb60
name: SGPL1
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:8879
is: SBO:0000252
constant: false
boundary condition: true
is: O95470

metaR r1644
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2361
reversible: true
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM 3mb2coa m
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: HMDB01493
has only substance units: false
name: 3-methylbut-2-enoyl-CoA(4-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57344
initial concentration: 1.0
constant: false

metaR CHSTEROLtrc
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
name: transport of cholesterol into the cytosol
reversible: true
fast: false
is described by: ECO:0000134

metaM sbt D c
has only substance units: false
initial amount: NaN
is: HMDB00247
type: Species
name: D-glucitol
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: CHEBI:17924
is: SBO:0000247
constant: false
boundary condition: false

metaM HC02206 c
is: SBO:0000247
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin C1(1-)
has only substance units: false
type: Species
boundary condition: false

metaR CYTK6
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110041#
product: MODEL1310110041#
name: cytidylate kinase (CMP,CTP)
reversible: true
type: Reaction

metaR r1790
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: false
fast: false
name: Y+LAT2 Utilized transport

metaR UMPK4
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#
name: UMP kinase (GTP)
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110041#

metaM cytd c
is: CHEBI:17562
has only substance units: false
is: C00475
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00089
is: SBO:0000247
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaR r2362
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#

metaR UMPK5
product: MODEL1310110041#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP)
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110041#

metaM 5oxpro c
boundary condition: false
is: HMDB00267
type: Species
is: CHEBI:57606
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
name: 5-oxoprolinate
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaR DCK2n
name: Deoxycytidine kinase, nuclear (UTP)
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)

metaM dump m
is: HMDB01409
is: CHEBI:246422
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
name: dUMP(2-)
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR AG13T3g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176

metaR r1645
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_8cfc076b_2d30_4072_af94_4c225a129dcc
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: Q96PD7
is encoded by: hsa:84649
name: DGAT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_536126c3_bb14_4955_bebd_56babe3a2556
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P04062
is encoded by: hsa:2629
name: GBA
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4356830e_1d88_4a98_ae53_59599cd6660b
has only substance units: false
type: Species
is: SBO:0000252
name: AGXT2L1
is encoded by: hsa:64850
is: Q8TBG4
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM trdox c
name: Oxidized thioredoxin
type: Species
is: C00343
has only substance units: false
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18191

http://identifiers.org/biomodels.db/MODEL1310110041#_47b80f85_7e22_4ddc_82f5_5c8feb3fa12a
constant: false
is: SBO:0000252
has only substance units: false
is: P32119
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:7001
name: PRDX2

metaR G14T16g
is: SBO:0000176
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
modifier: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_fced7fca_d926_45f2_a827_eee640d4d4f1
has only substance units: false
initial concentration: NaN
is: Q86WA9
type: Species
initial amount: NaN
name: SLC26A11
is: SBO:0000252
boundary condition: true
is encoded by: hsa:284129
constant: false

metaR M4MPDOL Uter
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
name: m4mpdol flippase
type: Reaction

metaR CYTK7
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_59fb7528_d92f_4b81_ae40_2e0a7c1a06f3
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_460e8ef9_d71b_4a77_a35c_fee18cd512fc
is: SBO:0000252
name: _BC005314_1_x
initial concentration: NaN
is encoded by: hsa:BC005314
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR r0480
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
fast: false
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#

metaR TYRCBOX
is: SBO:0000176
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.1.1.28
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#

metaR AMETr
name: S-Adenosyl-L-methionine intracellular diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_d46d4ed5_c934_4a6e_beab_c0461d59bad1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: MAN1A1
initial concentration: NaN
constant: false
is encoded by: hsa:4121
is: P33908
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_8ebf9edd_f78b_4844_82c7_51ff6fb9abbf
name: ACAD8
type: Species
is: SBO:0000252
constant: false
is: Q6ZWP6
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:27034
has only substance units: false

metaR r2363
reversible: true
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185

metaM CE2434 m
initial amount: NaN
is: C01936
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA

metaR r1633
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR UMPK6
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
name: UMP kinase (dCTP)

metaM na1 c
boundary condition: false
initial amount: NaN
is: C01330
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
name: Sodium
type: Species
is: SBO:0000247
is: CHEBI:4541

metaM sbt D e
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
constant: false
is: HMDB00247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-glucitol

metaR LEUKTRE4t
reversible: true
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
name: leukotriene E4 transport
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000185

metaR r1646
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksii core4 deg2 l
has only substance units: false
constant: false
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
type: Species
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 2
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN

metaR M13N2Tg
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.101
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110041#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaM 4mptnl m
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
initial amount: NaN
constant: false
is: CHEBI:17998
name: 4-methylpentanal
is: HMDB01318
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_7c9ae1e7_8abe_49c9_a3e0_ccd917eec1a3
initial amount: NaN
is encoded by: hsa:218
constant: false
boundary condition: true
name: ALDH3A1
has only substance units: false
initial concentration: NaN
is: P30838
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_3bd75dff_e1f7_4ef0_95c3_1a787f6dbba8
boundary condition: true
name: QPRT
is: Q15274
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:23475

metaR FAEL183
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
type: Reaction
modifier: MODEL1310110041#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
reversible: false

metaR r1589
fast: false
reactant: MODEL1310110041#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110041#

metaM s2l2n2m2masn e
name: de-Fuc form of PA6
is: HMDB00244
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: C00255
has only substance units: false
is: CHEBI:3554
boundary condition: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_3533e8ff_def9_44ba_bafa_22cdb0cc1a7c
boundary condition: true
is encoded by: hsa:224
type: Species
is: SBO:0000252
initial concentration: NaN
name: ALDH3A2
is: P51648
has only substance units: false
constant: false
initial amount: NaN

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
is: SBO:0000185

metaM accoa n
type: Species
is: HMDB01206
is: CHEBI:57288
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: acetyl-CoA(4-)
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
initial concentration: 1.0

metaM taur e
is: C00245
type: Species
notes: FORMULA: C2H7NO3S CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00251
is: CHEBI:3544
is: SBO:0000247
name: Taurine
constant: false

metaM ctp n
initial concentration: 1.0
is: CHEBI:37563
initial amount: NaN
constant: false
is: HMDB00082
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
name: CTP(4-)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e5a4ab12_0c4a_4bfa_8cf5_8124b3a7f258
is: SBO:0000252
is: Q9BZV2
constant: false
is encoded by: hsa:80704
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC19A3
type: Species

metaM hista e
is: SBO:0000247
initial concentration: 1.0
name: histamium
has only substance units: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
boundary condition: false
is: CHEBI:58432
constant: false
is: HMDB00870
initial amount: NaN
type: Species

metaM his L e
is: HMDB00177
is: CHEBI:15971
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine

metaR DNDPt23m
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110041#
name: dTDP transport via dGTP antiport
reversible: false
kinetic law: MODEL1310110041#
fast: false

metaM nadp r
type: Species
is: CHEBI:58349
boundary condition: false
initial amount: NaN
is: HMDB00217
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
is: SBO:0000247
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
constant: false

metaM akg c
constant: false
has only substance units: false
is: CHEBI:16810
boundary condition: false
is: C00026
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-Oxoglutarate
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_932dae8f_85ff_4a15_a428_9019acf80ed0
is: SBO:0000252
has only substance units: false
name: ST3GAL3
initial concentration: NaN
constant: false
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN
type: Species

metaR CYTK1m
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
type: Reaction
fast: false
kinetic law: MODEL1310110041#
name: cytidylate kinase (CMP),mitochondrial

metaM betald m
is: HMDB01252
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:15710
type: Species
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
name: betaine aldehyde
initial concentration: 1.0

metaM 4hoxpacd c
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB03767
is: CHEBI:15621
initial concentration: 1.0
initial amount: NaN
name: (4-hydroxyphenyl)acetaldehyde
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765

metaR BTNPLm
reversible: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false
product: MODEL1310110041#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110041#

metaM ppi x
type: Species
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: C00013
is: SBO:0000247
initial concentration: 1.0
name: Diphosphate
initial amount: NaN
is: HMDB00250
has only substance units: false
constant: false

metaR B3GNT31g
reversible: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c949c741_6ee8_4c47_a7ce_7764f22007cc
constant: false
type: Species
is: P07741
name: APRT
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:353
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_d4bd52fc_f2e6_43f3_b91e_dc87882cc4f7
constant: false
boundary condition: true
name: SLC23A1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9963
has only substance units: false
is: Q9UHI7

metaR DRPA
is: SBO:0000176
name: deoxyribose-phosphate aldolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM HC01406 m
is: SBO:0000247
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
type: Species
boundary condition: false
initial amount: NaN
name: 3-Oxooctanoyl-CoA
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28264

metaM udpacgal g
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
constant: false
is: SBO:0000247
is: HMDB00304
initial amount: NaN
type: Species
boundary condition: false

metaR RIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110041#
is described by: ECO:0000000
name: ribose transport via diffusion
fast: false
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR r1588
kinetic law: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110041#

metaM amp c
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: C00020
is: SBO:0000247
boundary condition: false
name: AMP
type: Species
initial concentration: 1.0
is: CHEBI:3322
initial amount: NaN
has only substance units: false
is: HMDB00045
constant: false

metaR r1626
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_6009924e_adcf_4199_b3cc_0f1e57244635
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q9BRC7
boundary condition: true
name: PLCD4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84812

metaR PRPNCOAHYDm
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
reactant: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay

http://identifiers.org/biomodels.db/MODEL1310110041#_97aa8acd_8112_4ba7_a785_0d0bb5509d2c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: Q6PCB7
is encoded by: hsa:376497
is: SBO:0000252
name: SLC27A1

metaM ctp m
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00082
type: Species
name: CTP(4-)
initial concentration: 1.0
is: CHEBI:37563

http://identifiers.org/biomodels.db/MODEL1310110041#_15b0ddce_a7d3_43c3_b72a_f2bc7ba54aa1
initial amount: NaN
is: Q9NQR4
boundary condition: true
is encoded by: hsa:56954
name: NIT2
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaM pail5p hs n
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: CHEBI:57795
initial amount: NaN

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_20c75333_3d97_421c_80e6_95b45a8f92ae
name: SDHC
constant: false
boundary condition: true
has only substance units: false
is: Q99643
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6391
initial amount: NaN

metaM lnlccoa m
name: linoleic coenzyme A
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164

metaR CYTK1n
name: cytidylate kinase (CMP),nuclear
is described by: ECO:0000269
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR ACONTm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
reactant: MODEL1310110041#
name: Aconitate hydratase
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is described by: ECO:0000134
product: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
reversible: true

metaR RE2649C
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#

metaM cmp g
name: CMP(2-)
is: CHEBI:60377
boundary condition: false
type: Species
constant: false
is: HMDB00095
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: SBO:0000247

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM 35cgmp c
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:57746
initial amount: NaN
boundary condition: false
name: 3',5'-cyclic GMP(1-)
is: HMDB01314
is: SBO:0000247
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942

metaM for c
is: CHEBI:15740
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Formate
constant: false
initial amount: NaN
is: C00058
has only substance units: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142

metaR r1434
name: Transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
fast: false
reversible: false

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
fast: false

metaM guln c
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB03290
type: Species
name: L-gulonate
initial amount: NaN
is: CHEBI:13115
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR GCCcm
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
name: glycine-cleavage complex (lipoylprotein), mitochondrial
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
product: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2

metaR r0579
modifier: MODEL1310110041#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.13.11.19
type: Reaction

metaR G14T5g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
reversible: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110041#

metaR DOPAtu
name: Dopamine uniport
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_f99b9716_9457_4e40_ba66_ad3a9cb8c043
is: Q9H6Y6
is encoded by: hsa:4645
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: MYO5B
constant: false
initial concentration: NaN

metaM taur c
name: Taurine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:3544
is: C00245
type: Species

metaM gcald c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
name: glycolaldehyde
initial amount: NaN
is: CHEBI:17071
is: HMDB03344
constant: false

metaM hista c
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
is: SBO:0000247
boundary condition: false
is: CHEBI:58432
constant: false
is: HMDB00870
initial amount: NaN
has only substance units: false
type: Species

metaR RE3567C
name: RE3567
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
kinetic law: MODEL1310110041#

metaR r0639
fast: false
type: Reaction
reactant: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_30bdb279_f03a_4551_8b13_2aa0818d96e5
constant: false
type: Species
is encoded by: hsa:80271
name: ITPKC
is: Q96DU7
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR RE3628M
reactant: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: RE3628
reversible: true
is: SBO:0000176

metaR NACHEXA22ly
type: Reaction
reactant: MODEL1310110041#
reversible: false
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

http://identifiers.org/biomodels.db/MODEL1310110041#_3b34b252_4841_4526_812c_f92e1feab911
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI631997
initial amount: NaN
name: _AI631997_1_m
constant: false
boundary condition: true

metaM his L c
has only substance units: false
is: HMDB00177
initial concentration: 1.0
is: CHEBI:15971
constant: false
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_7644c9f6_2cc0_4655_941a_e25ebed6c0c2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9583
is: SBO:0000252
initial amount: NaN
name: ENTPD4
is: Q9Y227
constant: false
type: Species
has only substance units: false

metaM ksi deg20 l
name: keratan sulfate I, degradation product 20
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00143
is: CHEBI:12936
boundary condition: false
initial amount: NaN
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
initial concentration: 1.0
constant: false

metaR DALAt2r
modifier: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
type: Reaction
fast: false
is described by: ECO:0000304
name: D-alanine transport via proton symport
product: MODEL1310110041#

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_317fa6ed_8934_41ca_8fdf_dedf2a2030f8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2629
is: B7Z6S1
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: GBA
type: Species

metaR CHAT
product: MODEL1310110041#
type: Reaction
reversible: true
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.6
is described by: ECO:0000269
name: Choline O-acetyltransferase
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176

metaR FAOXC200180m
name: Beta oxidation of long chain fatty acid
reversible: false
modifier: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM etoh e
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00108
name: ethanol
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: CHEBI:16236
initial concentration: 1.0
initial amount: NaN
type: Species

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: CHEBI:57667
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: dADP(3-)
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01508
constant: false

metaR r1624
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_0488dac8_6fed_4287_9204_04dd4101fba9
name: NME4
constant: false
has only substance units: false
is: O00746
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:4833

metaR r0578
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110041#
is: SBO:0000176
fast: false

metaR AG13T11g
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110041#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r1586
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

metaR THYMt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: thymine reversible transport via facilated diffusion
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185
type: Reaction

metaR r1433
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reactant: MODEL1310110041#

metaR r0527
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
product: MODEL1310110041#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:

metaR r1659
modifier: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110041#
reversible: true

metaM accoa m
constant: false
type: Species
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Acetyl-CoA
is: C00024
is: CHEBI:57288

metaM amp e
is: SBO:0000247
is: C00020
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00045
name: AMP
initial concentration: 1.0
constant: false
is: CHEBI:456215
has only substance units: false

metaR B3GNT39g
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000000
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110041#
modifier: MODEL1310110041#

metaM h c
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: C00080
is: CHEBI:24636
is: SBO:0000247
name: proton
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "

metaM co2 e
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01967
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
name: CO2
is: C00011
initial amount: NaN

metaM cmp e
is: SBO:0000247
boundary condition: false
is: CHEBI:60377
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
initial concentration: 1.0
is: HMDB00095
name: CMP(2-)
initial amount: NaN

metaM malcoa c
name: Malonyl-CoA
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
is: HMDB01175
boundary condition: false
initial concentration: 1.0
type: Species
is: C00083
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57384

metaR S6T17g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110041#
is: SBO:0000176

metaR RDH1a
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
fast: false
name: retinol dehydrogenase (all-trans,NADPH)
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.300

http://identifiers.org/biomodels.db/MODEL1310110041#_e8255d04_fefc_4b6a_93ce_ca4ea70eb880
initial concentration: NaN
type: Species
has only substance units: false
name: ENTPD8
is encoded by: hsa:377841
constant: false
initial amount: NaN
is: Q5MY95
boundary condition: true
is: SBO:0000252

metaR 4HGLSDm
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000212
fast: false
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_c9bc23a4_35e7_4aef_9c50_2565dc1671a6
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI934540
constant: false
name: _AI934540_1_c
initial amount: NaN

metaR r0129
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
is: SBO:0000176
fast: false
type: Reaction

metaM for e
is: CHEBI:15740
is: HMDB00142
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
name: formate
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_fb7d1b5d_8146_4f96_9015_974e6d68f02a
type: Species
has only substance units: false
name: MAN2B1
is encoded by: hsa:4125
is: SBO:0000252
constant: false
initial amount: NaN
is: O00754
initial concentration: NaN
boundary condition: true

metaR r1629
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

metaM retinol 9 cis c
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17336
constant: false
is: HMDB06217
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: SBO:0000247
name: 9-cis-retinol
boundary condition: false
initial amount: NaN

metaR r1585
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GCHOLAte
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is: SBO:0000185
fast: false
name: bile acid intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_44863027_81b9_4aef_9070_3537fe3329cd
name: COX8A
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q53XN1
is encoded by: hsa:1351

http://identifiers.org/biomodels.db/MODEL1310110041#_b4e13ae0_5234_4481_b002_7be3f813a1cf
name: CHAT
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103
has only substance units: false
initial concentration: NaN
type: Species
is: Q6LEN6
initial amount: NaN
constant: false

metaR r0464
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
product: MODEL1310110041#
is: SBO:0000176

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM etoh c
boundary condition: false
type: Species
is: SBO:0000247
name: ethanol
constant: false
initial concentration: 1.0
is: HMDB00108
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: CHEBI:16236
has only substance units: false
initial amount: NaN

metaR MACACI
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
name: maleylacetoacetate isomerase
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269
fast: false

metaM HC01522 c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
name: Gentisate aldehyde
type: Species
is: CHEBI:28508
is: SBO:0000247
constant: false
boundary condition: false

metaM m5masnC g
boundary condition: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:58469
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01313
type: Species
constant: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
initial concentration: 1.0

metaR FCLTm
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.99.1.1
type: Reaction
fast: false
is described by: ECO:0000304
product: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
name: Ferrochelatase, mitochondrial
reactant: MODEL1310110041#
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_0a1eb09c_de67_4122_bc32_fae89c105862
name: NDUFA6
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4700
is: P56556
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM ksii core4 pre5 g
boundary condition: false
is: CHEBI:58053
is: C00130
is: SBO:0000247
notes: FORMULA: C69H112N6O48X CHARGE: -1
initial amount: NaN
initial concentration: 1.0
constant: false
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
type: Species
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110041#_d607cc38_4901_47a8_bab9_2c380aae0964
is encoded by: hsa:2591
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: GALNT3
initial amount: NaN
is: Q14435

metaR PRDX
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.11.1.7
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
modifier: MODEL1310110041#
name: Peroxidase (multiple substrates)
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
reversible: false
fast: false

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaM idp e
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
is: HMDB03335
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58280
boundary condition: false
type: Species

metaR DOLMANP Uter
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
name: dolichol-phosphate mannose flippase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction

metaM udpacgal c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57847
has only substance units: false
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
type: Species
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)

metaR r1584
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR r2043
kinetic law: MODEL1310110041#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR ALDD2x
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
modifier: MODEL1310110041#
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110041#

metaR r0853
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110041#
is described by: ECO:0000000
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110041#_b4cf51db_c49e_4177_bde7_d02461a179a1
has only substance units: false
is encoded by: hsa:11226
name: GALNT6
initial concentration: NaN
constant: false
boundary condition: true
is: Q8NCL4
is: SBO:0000252
initial amount: NaN
type: Species

metaR PROSTGE2t
name: prostaglandin transport via bicarbonate countertransport
reversible: true
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269

metaM frdp x
constant: false
has only substance units: false
is: HMDB00961
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: farnesyl pyrophosphate(3-)
is: CHEBI:175763
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

http://identifiers.org/biomodels.db/MODEL1310110041#_4367f907_5c76_47e7_814b_f9cf27200e1c
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3418
name: IDH2
initial amount: NaN
is: P48735
is: SBO:0000252
initial concentration: NaN
type: Species

metaM 34hpp c
boundary condition: false
initial amount: NaN
is: HMDB00707
has only substance units: false
initial concentration: 1.0
is: CHEBI:36242
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: SBO:0000247
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
constant: false

metaM xylt c
is: CHEBI:17151
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02917
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
name: xylitol

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR XOL27OHtm
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaM dhlam m
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial amount: NaN
initial concentration: 1.0
is: HMDB00985
is: CHEBI:17694
type: Species
boundary condition: false
is: SBO:0000247
name: dihydrolipoamide
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_131eab64_48d4_490f_9637_6f319d4b7284
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: P55084
is encoded by: hsa:3032
name: HADHB
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR AMPtp
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
name: AMP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
product: MODEL1310110041#
fast: false
reversible: true

metaR r1627
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
is: SBO:0000185

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR r0127
kinetic law: MODEL1310110041#
type: Reaction
reversible: false
fast: false
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
is: SBO:0000176

metaR DHPM1
is version of: http://identifiers.org/ec-code/3.5.2.2
is: SBO:0000176
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
name: dihydropyrimidinase (5,6-dihydrouracil)
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR r0575
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#

metaR r2042
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
fast: false

metaR r0522
is described by: ECO:0000000
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_0059670e_fdd4_4cb8_bc2a_a2b58eec8dac
is: Q9Y2C3
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:10317
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110041#_383f2ca1_8c2f_41e6_8015_0e9b563daf26
has only substance units: false
initial amount: NaN
constant: false
is: P23786
is: SBO:0000252
name: CPT2
type: Species
initial concentration: NaN
is encoded by: hsa:1376
boundary condition: true

metaR SPODM
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reversible: false
modifier: MODEL1310110041#
name: superoxide dismutase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110041#

metaR r2369
fast: false
kinetic law: MODEL1310110041#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#

metaR r1583
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
fast: false
reversible: true
product: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_22d5504b_2fbf_4222_ab38_c6c34cc9b7cc
has only substance units: false
boundary condition: true
name: NDUFS2
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4720
initial amount: NaN
is: SBO:0000252
is: B7Z792

http://identifiers.org/biomodels.db/MODEL1310110041#_57b6a5a8_85fd_4cd6_a462_193ea2523d98
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3707
constant: false
name: ITPKB
has only substance units: false
initial amount: NaN
is: P27987
boundary condition: true
type: Species

metaM zymst r
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
type: Species
is: CHEBI:18252
initial amount: NaN
name: zymosterol
boundary condition: false
is: SBO:0000247
is: HMDB06271

http://identifiers.org/biomodels.db/MODEL1310110041#_125b88d1_0ab9_4cbc_8738_0efd0a9b8f3b
is: G3XAJ0
is encoded by: hsa:80724
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: ACAD10
type: Species
has only substance units: false

metaR RE1898C
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
reversible: true
name: RE1898
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

metaM akg e
initial concentration: 1.0
type: Species
is: CHEBI:16810
name: 2-oxoglutarate(2-)
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00208
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_399ae12f_a969_43cb_9f79_a942484c3e9e
is: Q8N695
boundary condition: true
name: SLC5A8
is encoded by: hsa:160728
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_26a988b0_f0d1_4c66_bf0a_45389a94d265
type: Species
name: STARD3
is encoded by: hsa:10948
boundary condition: true
is: B4DUY1
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM dcamp c
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536
is: SBO:0000247
is: CHEBI:57567
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: C03794
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0

metaR r1628
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR HAtly
reversible: false
fast: false
name: hyaluronan transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#

metaM idp c
is: HMDB03335
boundary condition: false
initial concentration: 1.0
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9fcd26ab_3f6a_4e3f_b02d_f1a1a15a6bc4
is: O95573
constant: false
is encoded by: hsa:2181
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ACSL3

metaR DHPM2
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: dihydropyrimidinase (dihydrothymine)
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR MMCDm
is: SBO:0000176
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.9
modifier: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
reversible: false
name: Methylmalonyl-CoA decarboxylase, mitochondrial
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_ba9e5891_cbe9_46b3_b6fb_13f4899b98f7
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AL525798
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AL525798_1_c
type: Species

metaR r0523
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110041#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
product: MODEL1310110041#
is: SBO:0000176

metaR GLNtm
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
name: L-glutamine transport via electroneutral transporter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
product: MODEL1310110041#
is: SBO:0000185

metaM datp c
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
type: Species
name: dATP
initial amount: NaN
initial concentration: 1.0
is: C00131
is: HMDB01532
is: CHEBI:61404
boundary condition: false
has only substance units: false

metaM CE0849 m
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
is: C01936
type: Species
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849

http://identifiers.org/biomodels.db/MODEL1310110041#_e017160b_0a43_4de0_b1d7_d02b0db2398e
is encoded by: hsa:3635
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: INPP5D
is: Q92835
constant: false
boundary condition: true
initial amount: NaN

metaR r2368
reversible: true
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4ca51f06_7597_4f2b_b279_7a10975b1633
boundary condition: true
constant: false
is encoded by: hsa:2348
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: FOLR1

metaM gchola c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58235
type: Species
is: HMDB00138
name: glycocholate
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false

metaM 34hpp e
initial amount: NaN
boundary condition: false
is: HMDB00707
is: CHEBI:36242
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1

metaM xylt e
boundary condition: false
is: CHEBI:17151
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: HMDB02917
name: xylitol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_9d4781e8_e449_452d_9845_ca7d28efa5a2
name: B3GALNT1
boundary condition: true
constant: false
is: Q8TDY1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8706
has only substance units: false
type: Species

metaM udpglcur c
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
has only substance units: false
is: CHEBI:58052
constant: false
initial concentration: 1.0
is: HMDB00935
initial amount: NaN
name: UDP-D-glucuronate
is: SBO:0000247
type: Species
boundary condition: false

metaR CERT2rt
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
name: ceramide transport protein
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_4a932860_039d_444a_a617_0a2e4f005a88
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: PIP5K1C
is: O60331
has only substance units: false
is: SBO:0000252
is encoded by: hsa:23396
boundary condition: true

metaR r0633
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110041#
is: SBO:0000176
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_e7e4809c_d55e_4522_91b7_4c89b96ba023
boundary condition: true
constant: false
is encoded by: hsa:93034
name: NT5C1B
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q96P26
initial concentration: NaN
type: Species

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#

metaR ABO4g
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR 3HBCOAHLm
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
product: MODEL1310110041#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reactant: MODEL1310110041#

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_0417dfb3_fb1d_4510_a73a_f6819a54d45d
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI697028
is: SBO:0000252
boundary condition: true
name: _AI697028_1_e

metaM ksii core4 pre9 g
initial concentration: 1.0
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: keratan sulfate II biosynthesis, precursor 9
is: CHEBI:28067
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a07c847c_89ce_4c29_880e_5a96f12baec3
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:157506
has only substance units: false
type: Species
is: Q8IZV5
name: RDH10

metaM gchola e
name: glycocholate
constant: false
is: HMDB00138
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0

metaM 2mop c
is: CHEBI:57700
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01172
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM HC02217 e
type: Species
is: SBO:0000247
is: CHEBI:27647
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
name: prostaglandin-g2
has only substance units: false

metaR THMDt4
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
name: thymidine transport in via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110041#_32111ea2_41eb_43f2_aed9_ebd8c202ba16
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:276
constant: false
has only substance units: false
is: Q6NSB3
name: AMY1A
initial amount: NaN
type: Species

metaR r0634
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.4.1
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#

metaM s2l2n2m2masn l
name: de-Fuc form of PA6
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: SBO:0000247
initial amount: NaN
is: HMDB00174
has only substance units: false
is: CHEBI:18287
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

metaM sphs1p c
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
boundary condition: false
is: HMDB00277
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_674a261b_781d_4a15_84fe_bfc6ed27095b
boundary condition: true
name: _AI640625_1_c
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI640625
constant: false

metaR TDCHOLAte
is: SBO:0000185
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reversible: true
product: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_20d91e52_e97b_4c9f_9760_8cb0bbc402a3
initial amount: NaN
name: PPCDC
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q96CD2
is: SBO:0000252
constant: false
is encoded by: hsa:60490

http://identifiers.org/biomodels.db/MODEL1310110041#_0e9f2af7_c924_4437_ad39_eb0a6f9882a3
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _U52111_1_c
is encoded by: hsa:U52111

http://identifiers.org/biomodels.db/MODEL1310110041#_59df6e75_66c5_47b8_aa2c_bf826b305850
type: Species
is encoded by: hsa:377677
constant: false
initial amount: NaN
is: Q8N1Q1
is: SBO:0000252
has only substance units: false
name: CA13
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_50dda25b_dec3_42c2_aea0_68533d4bdf88
is: Q9H2X9
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:57468
has only substance units: false
name: SLC12A5
type: Species

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

metaM ppi n
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: CHEBI:33019
initial concentration: 1.0
name: diphosphate(3-)
is: HMDB00250
boundary condition: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR GLYCLTtp
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
name: glycolate transport into peroxisome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD

metaM ptth m
type: Species
name: pantetheine
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
is: CHEBI:16753
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_13061be4_eb19_4dd7_9465_f02f4a5711ba
name: SYNJ1
boundary condition: true
is encoded by: hsa:8867
has only substance units: false
is: O43426
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_73159a7d_73bd_4e5f_bf85_2219b441b6f5
is: O43772
is: SBO:0000252
boundary condition: true
type: Species
name: SLC25A20
is encoded by: hsa:788
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR THMMPtm
name: Thiamine monophosphate transport, mitochondrial
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: true
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110041#_5bd177a7_71a1_43cc_88b1_99423c41a4fd
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q92781
name: RDH5
constant: false
type: Species
is encoded by: hsa:5959

http://identifiers.org/biomodels.db/MODEL1310110041#_9cd98b74_c0dc_468a_bd9d_ab5481c7b954
is encoded by: hsa:26290
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: GALNT8
is: Q9NY28
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_f802da90_2868_42db_82ac_92cf48ee8ef8
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:60386
is: Q9HC21
type: Species
name: SLC25A19
is: SBO:0000252

metaR TSTSTERONEt
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
fast: false
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
name: Testosterone transport

metaM ksi pre34 g
initial amount: NaN
is: C00130
is: CHEBI:58053
constant: false
initial concentration: 1.0
is: HMDB00175
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 34

metaR ALDD2y
product: MODEL1310110041#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reversible: false
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177

metaM hmbil c
is: HMDB01137
boundary condition: false
constant: false
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
name: Hydroxymethylbilane
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57845
is: C01024

metaR FUMTSULtm
name: Fumarate:thiosulfate antiport, mitochondrial
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true

metaM tststerone e
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17347
name: testosterone
boundary condition: false
has only substance units: false
is: HMDB00234

metaM ppi m
name: Diphosphate
initial concentration: 1.0
has only substance units: false
is: C00013
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:33019
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110041#_6d2ab5eb_d739_433a_b307_dab65dac5a1a
is: O94903
name: PROSC
constant: false
is encoded by: hsa:11212
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_400f7b7f_3b8b_4178_b1ce_c0417da6866b
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q9NWU1
is encoded by: hsa:54995
constant: false
name: OXSM
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
constant: false
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
type: Species
is: HMDB00257
is: CHEBI:16094
initial amount: NaN

metaR PYRt2m
product: MODEL1310110041#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
fast: false
type: Reaction
name: pyruvate mitochondrial transport via proton symport
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_ccbb4764_1ad7_41b4_836f_c39546adfb56
initial concentration: NaN
has only substance units: false
is encoded by: hsa:221
is: P43353
initial amount: NaN
constant: false
name: ALDH3B1
is: SBO:0000252
boundary condition: true
type: Species

metaR NACHEXA16ly
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
name: beta-N-acetylhexosaminidase A, lysosomal

metaM HC02217 c
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:27647
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
name: prostaglandin-g2
has only substance units: false
constant: false

metaR r0570
fast: false
is version of: http://identifiers.org/ec-code/6.3.3.2
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
modifier: MODEL1310110041#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is: SBO:0000176

metaM frdp r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
initial amount: NaN
type: Species
name: Farnesyl diphosphate
is: C00448
constant: false
is: HMDB00961
is: SBO:0000247
is: CHEBI:175763

http://identifiers.org/biomodels.db/MODEL1310110041#_690fec7d_6e16_4c71_8f0f_36fffb84f809
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: F5H2Y9
name: ALDH1A2
is: SBO:0000252
is encoded by: hsa:8854
type: Species

metaM sphs1p e
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
type: Species
is: HMDB00277
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:60119
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)

metaM fald e
type: Species
is: HMDB01426
name: formaldehyde
constant: false
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial concentration: 1.0
is: CHEBI:16842
boundary condition: false
has only substance units: false
initial amount: NaN

metaM chsterol c
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
boundary condition: false
is: CHEBI:16113
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00067
name: cholesterol

http://identifiers.org/biomodels.db/MODEL1310110041#_b8595ce2_29e9_48f7_a125_239a8d3b1568
has only substance units: false
constant: false
initial amount: NaN
is: O43505
type: Species
name: B3GNT1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:11041
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_0fcc722c_0f76_4eeb_b1f0_8356142488df
initial amount: NaN
is encoded by: hsa:2519
is: Q9BTY2
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: FUCA2
type: Species

metaR ABO9g
is described by: ECO:0000269
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
type: Reaction
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37

metaR B3GNT311g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110041#
reversible: false
is described by: ECO:0000254
reactant: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_e471de64_a100_4f98_bc1a_02aa1a662322
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9HCQ5
is encoded by: hsa:50614
type: Species
name: GALNT9

metaM gdp c
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: C00035
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
name: GDP
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9f64a758_e4c9_46b3_ae6c_8a527bee54c2
type: Species
initial concentration: NaN
initial amount: NaN
name: PDE1A
is: SBO:0000252
is encoded by: hsa:5136
constant: false
boundary condition: true
has only substance units: false
is: Q9Y633

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR HIBDm
fast: false
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
kinetic law: MODEL1310110041#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.31
product: MODEL1310110041#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial

metaR S6T3g
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110041#
reversible: false
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.8.2.17
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110041#
is described by: ECO:0000000

metaR SERt4
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: L-serine via sodium symport
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269

metaR ACGAMPM
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.2.3
name: phosphoacetylglucosamine mutase
modifier: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is: SBO:0000176
product: MODEL1310110041#
fast: false

metaR RTOTALFATPc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR CHLtm
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
name: choline transport via diffusion (cytosol to mitochondria)
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000

metaM tststerone c
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
name: testosterone
has only substance units: false
is: CHEBI:17347
type: Species
is: HMDB00234

http://identifiers.org/biomodels.db/MODEL1310110041#_bd0b92c6_a46a_43cd_a401_45076528e6fa
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: P14618
name: PKM2
is encoded by: hsa:5315
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_ce4cdb42_7d8a_4687_b81a_c819441e5514
is encoded by: hsa:10797
name: MTHFD2
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: P13995
is: SBO:0000252
boundary condition: true

metaM HC01397 m
type: Species
constant: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial concentration: 1.0
has only substance units: false
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_bfc817b9_4b40_44bd_80b5_28e60a39b8b4
is encoded by: hsa:3155
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: HMGCL
is: Q6IBC0
type: Species
is: SBO:0000252

metaM co2 c
notes: FORMULA: CO2 CHARGE: 0
is: CHEBI:3313
name: CO2
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01967
has only substance units: false
constant: false
is: C00011
is: SBO:0000247

metaM cmp c
is: HMDB00095
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: C00055
constant: false
name: CMP
is: CHEBI:60377
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_60be2e4b_e4f4_47d9_ba37_376ab81b3333
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6487
boundary condition: true
type: Species
name: ST3GAL3

metaM udpacgal l
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
initial amount: NaN

metaM dadp n
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57667
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP(3-)
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01508

metaM ksi pre6 g
notes: FORMULA: C107H174N7O80SX CHARGE: -2
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 6
initial concentration: 1.0
type: Species
is: C00130
is: CHEBI:58053
has only substance units: false
constant: false
boundary condition: false
is: HMDB00175
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_2e0ab374_75c8_499f_9627_522e5dde9e89
constant: false
initial concentration: NaN
is encoded by: hsa:6389
has only substance units: false
initial amount: NaN
boundary condition: true
is: P31040
is: SBO:0000252
type: Species
name: SDHA

metaR RE3556C
name: RE3556
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
fast: false

metaR PCHOL HSter
reactant: MODEL1310110041#
reversible: true
name: phosphatidylcholine scramblase
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185

metaR r0638
kinetic law: MODEL1310110041#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110041#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false

metaM chsterol e
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
is: CHEBI:16113
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00067
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM nadph c
is: CHEBI:57783
is: C00005
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00221
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN

metaR r1431
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110041#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
fast: false
product: MODEL1310110041#
is: SBO:0000176
reversible: false

metaR RE3005M
is described by: ECO:0000000
name: RE3005
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110041#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_2c329c56_3937_421a_923f_2f602e472248
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI373818
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI373818_1_m
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_3db89b83_afbf_47ae_81c9_2664600785c7
constant: false
is: SBO:0000252
has only substance units: false
name: RPE
type: Species
is encoded by: hsa:6120
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q96AT9

http://identifiers.org/biomodels.db/MODEL1310110041#_26da2bca_4c1c_42f1_a288_0b712f4198f5
is: Q5T4W8
is encoded by: hsa:6487
type: Species
name: ST3GAL3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR MANtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
name: mannose efflux from lysosome
reactant: MODEL1310110041#
reversible: false

metaM CE4876 r
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
type: Species
has only substance units: false
name: delta12-Prostaglandin J2
initial amount: NaN
constant: false
is: CHEBI:12947
is: SBO:0000247
initial concentration: 1.0

metaM mal L m
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15589
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1923d10d_4924_49ba_a35f_eaa72c6a13f7
initial amount: NaN
constant: false
is encoded by: hsa:BE966236
initial concentration: NaN
name: _BE966236_1_m
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16094
type: Species
initial concentration: 1.0
is: HMDB00257
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_11944962_327f_4ac3_959b_4171564943d8
name: RRM2B
constant: false
is: Q7LG56
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:50484
initial concentration: NaN

metaR SERDGLYexR
fast: false
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
name: D-Serine/Glycine reversible exchange
modifier: MODEL1310110041#
is described by: ECO:0000304
is: SBO:0000185

metaM ppi r
is: CHEBI:33019
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: HMDB00250
name: Diphosphate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00013

metaR NADtx
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of NAD into peroxisome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_28b78c83_ca51_40e2_8642_a4965c83cce4
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: RPN1
is encoded by: hsa:6184
is: P04843
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6ceff55a_b136_4578_b1b4_f31b7a96569e
is encoded by: hsa:11182
constant: false
initial concentration: NaN
name: SLC2A6
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q9UGQ3
boundary condition: true

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaR DAGK hs
modifier: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
name: Diacylglycerol phosphate kinase (homo sapiens)
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.107
reversible: true
fast: false
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_1877be4c_044c_48d2_b57d_6fd62ab6252e
name: BAAT
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q14032
initial concentration: NaN
is encoded by: hsa:570

metaR DOLDPP Uer
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
product: MODEL1310110041#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.43
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a345eadb_1a37_4506_b875_8196d59edf56
type: Species
initial concentration: NaN
is encoded by: hsa:1737
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q86YI5
is: SBO:0000252
constant: false
name: DLAT

metaR ALOX52
fast: false
reversible: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is version of: http://identifiers.org/ec-code/1.13.11.34
type: Reaction
is described by: ECO:0000269
name: Arachidonate 5-lipoxygenase

http://identifiers.org/biomodels.db/MODEL1310110041#_174e808f_8857_48bf_833a_80585b982e00
has only substance units: false
boundary condition: true
name: ATP1A4
is: Q13733
type: Species
is encoded by: hsa:480
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR AK2LGCHOLt
product: MODEL1310110041#
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
type: Reaction
is: SBO:0000185

metaR VALt4
product: MODEL1310110041#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
modifier: MODEL1310110041#
type: Reaction
name: L-valine transport in via sodium symport
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8413d6c8_c1ce_466f_aa62_e8347cfa8fe7
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR FE3MTP1
product: MODEL1310110041#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110041#
is described by: ECO:0000134
modifier: MODEL1310110041#
type: Reaction
fast: false
kinetic law: MODEL1310110041#
name: transport of ferrous iron into blood

metaM crm hs r
name: N-acylsphingosine
constant: false
initial amount: NaN
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_9e16f2ae_bcaf_4147_8f50_9f9f0354ee45
constant: false
initial amount: NaN
is: P31639
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC5A2
is encoded by: hsa:6524

http://identifiers.org/biomodels.db/MODEL1310110041#_28b1b38f_a88e_4f8d_84c8_ec1e9fe32286
constant: false
name: HSD3B2
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P26439
is encoded by: hsa:3284
has only substance units: false
initial amount: NaN

metaR NDPK3m
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
reactant: MODEL1310110041#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110041#

metaR NMNATr
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
name: nicotinamide-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2e1cea5a_c6ad_40b1_8d99_bb349f1bce20
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q92947
name: GCDH
initial amount: NaN
constant: false
is encoded by: hsa:2639

http://identifiers.org/biomodels.db/MODEL1310110041#_d636f61a_d01f_439f_ab09_1726aee01008
type: Species
initial concentration: NaN
name: _AI935189_1_m
boundary condition: true
is encoded by: hsa:AI935189
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5585402e_67a1_4a0c_b652_a18bed7abf23
initial concentration: NaN
is: SBO:0000252
name: GALE
type: Species
initial amount: NaN
constant: false
is: Q38G75
has only substance units: false
boundary condition: true
is encoded by: hsa:2582

metaM g1p c
has only substance units: false
constant: false
boundary condition: false
type: Species
name: D-Glucose 1-phosphate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58601
is: HMDB01586
is: C00103
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103

http://identifiers.org/biomodels.db/MODEL1310110041#_78055a50_dc8f_4100_aa44_f96e8d4c5899
type: Species
constant: false
is: Q76EJ3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11046
name: SLC35D2
has only substance units: false
initial amount: NaN

metaM 3mob e
initial amount: NaN
type: Species
is: HMDB00019
constant: false
boundary condition: false
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1

metaM prostgd2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
constant: false
is: SBO:0000247
is: CHEBI:57406
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: prostaglandin D2(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_b768d308_77b0_4794_b7df_a6eee44d8e47
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:8801
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q96I99
name: SUCLG2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_14c2ceca_2def_462b_af72_ebcb686d189a
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9UHI5
initial concentration: NaN
is encoded by: hsa:23428
boundary condition: true
name: SLC7A8
constant: false

metaM uppg3 c
is: C01051
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Uroporphyrinogen III
type: Species
constant: false
is: HMDB01086
initial amount: NaN
is: SBO:0000247
is: CHEBI:57308

http://identifiers.org/biomodels.db/MODEL1310110041#_d1b2ae4f_4722_4e36_9e3b_cd5861cdef91
is: Q15111
is encoded by: hsa:5334
name: PLCL1
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM maltpt e
is: HMDB01296
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial amount: NaN
is: C02052
boundary condition: false
has only substance units: false
name: maltopentaose
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141

metaR r0280
fast: false
reactant: MODEL1310110041#
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_5e402df8_af25_489d_a286_4a5ee476a474
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: B4GALT1
is encoded by: hsa:2683
is: P15291

metaR CDSm
is version of: http://identifiers.org/ec-code/2.7.7.41
name: phosphatidate cytidylyltransferase
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
reversible: false
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
type: Reaction

metaR RE1254C
reversible: true
type: Reaction
name: RE1254
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:

metaR O2St
fast: false
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
name: superoxide anion transport via diffusion (extracellular)

http://identifiers.org/biomodels.db/MODEL1310110041#_453c8ccf_7b91_4c74_9586_59b34144e4d4
type: Species
boundary condition: true
constant: false
is encoded by: hsa:3945
is: P07195
name: LDHB
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM ksi deg27 l
initial concentration: 1.0
type: Species
is: HMDB00143
initial amount: NaN
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 27
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR FUCASE2e
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
product: MODEL1310110041#
name: alpha-fucosidase, extracellular
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#
modifier: MODEL1310110041#

metaM pheme m
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
is: C00032
initial concentration: 1.0
name: Protoheme
type: Species
is: HMDB03178

metaM 5mdru1p c
initial concentration: 1.0
notes: FORMULA: C6H11O7PS CHARGE: -2
is: SBO:0000247
initial amount: NaN
is: CHEBI:58548
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
type: Species
constant: false
has only substance units: false
is: HMDB01299
boundary condition: false
is: C04582

metaR r2371
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR GLCNACT U
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is described by: ECO:0000000
product: MODEL1310110041#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2e664809_21f6_4fa6_b264_3d96dcda4a74
name: MCCC2
initial concentration: NaN
is: Q9HCC0
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:64087
is: SBO:0000252
type: Species

metaM 1pipdn2c x
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084
type: Species
is: CHEBI:16187
initial amount: NaN
initial concentration: 1.0
name: 1-piperideine-2-carboxylate
constant: false

metaR r2526
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_11ba6192_4e80_42f7_abfd_9d0dcfd135a5
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51022
initial amount: NaN
boundary condition: true
type: Species
is: Q9NS18
is: SBO:0000252
name: GLRX2

http://identifiers.org/biomodels.db/MODEL1310110041#_1c9cf24a_6d65_479e_ad94_e6ed00b79a02
is: SBO:0000252
is: Q16851
boundary condition: true
initial amount: NaN
name: UGP2
initial concentration: NaN
type: Species
is encoded by: hsa:7360
has only substance units: false
constant: false

metaM b2coa m
is: CHEBI:57332
initial concentration: 1.0
is: SBO:0000247
is: HMDB02009
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
type: Species
has only substance units: false

metaR DOLASNT Uer
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.119
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110041#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110041#_ad2b2c53_39b5_4abb_ac52_cd951ead4b33
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PCBD1
constant: false
is encoded by: hsa:5092
type: Species
is: SBO:0000252
boundary condition: true

metaM ptth c
has only substance units: false
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
boundary condition: false
type: Species
constant: false
is: CHEBI:16753
is: SBO:0000247
initial concentration: 1.0
name: pantetheine
initial amount: NaN

metaM gdp g
is: CHEBI:58189
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: GDP(3-)
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN
type: Species
is: HMDB01201

http://identifiers.org/biomodels.db/MODEL1310110041#_d56abfa2_b87a_4151_ad07_2cceb4148e83
boundary condition: true
name: SGMS1
constant: false
initial amount: NaN
is: D3DWC4
has only substance units: false
is encoded by: hsa:259230
type: Species
is: SBO:0000252
initial concentration: NaN

metaM dhf m
is: HMDB01056
name: dihydrofolate(2-)
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57451
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_935cf898_6b6e_4aa7_9048_c03ef78e60d9
type: Species
has only substance units: false
is encoded by: hsa:7296
initial concentration: NaN
constant: false
is: SBO:0000252
name: TXNRD1
initial amount: NaN
boundary condition: true

metaR PPM
product: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.2
fast: false
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: phosphopentomutase
type: Reaction
is: SBO:0000176

metaM gluside hs r
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368

http://identifiers.org/biomodels.db/MODEL1310110041#_3d457dec_d8eb_479e_bc38_b0999c4452ca
is encoded by: hsa:83594
constant: false
is: Q9BQG2
type: Species
initial amount: NaN
name: NUDT12
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM 3mob c
has only substance units: false
is: HMDB00019
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species
is: CHEBI:11851
boundary condition: false
name: 3-methyl-2-oxobutanoate
constant: false

metaM g1p e
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01586
is: CHEBI:58601
type: Species
is: SBO:0000247
boundary condition: false
name: alpha-D-glucose 1-phosphate(2-)
has only substance units: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_3d989c9f_0313_4073_8eb4_fde6792a66ea
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:10400
initial concentration: NaN
name: PEMT
boundary condition: true

metaM adp x
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
initial concentration: 1.0
is: CHEBI:456216
type: Species
name: ADP(3-)
boundary condition: false
is: HMDB01341
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_379558ba_77b5_48c3_932a_080246206b39
initial concentration: NaN
name: COX2
initial amount: NaN
is: Q7GXZ8
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4513

metaM ha e
constant: false
is: CHEBI:16336
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
type: Species
name: hyaluronan
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_ffd1910e_ea89_47ec_8dfb_6313299bba99
is: SBO:0000252
constant: false
initial amount: NaN
name: LDHD
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:197257
boundary condition: true
is: Q86WU2

http://identifiers.org/biomodels.db/MODEL1310110041#_5393c156_c20a_482b_94d0_294f45d7ace9
is: P14060
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:3283
has only substance units: false
initial concentration: NaN
name: HSD3B1

metaR TYROXDAc
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
kinetic law: MODEL1310110041#
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is described by: ECO:0000269
product: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f8840e3d_2c45_479f_9feb_c89163a7bdaf
is encoded by: hsa:AI620219
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI620219_1_m
boundary condition: true

metaR MMEm
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
name: methylmalonyl-CoA epimerase/racemase
product: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.1
reactant: MODEL1310110041#

metaR r0340
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.38
modifier: MODEL1310110041#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
kinetic law: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
product: MODEL1310110041#

metaR RE0830N
name: RE0830
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#

metaR GGH 7DHFe
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is described by: ECO:0000000
reversible: false
product: MODEL1310110041#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

metaR PIter
is described by: ECO:0000212
name: phosphate transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110041#
is: SBO:0000185
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
type: Reaction
fast: false

metaM h r
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: C00080
constant: false
type: Species
has only substance units: false
boundary condition: false

metaM dhf l
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57451
constant: false
is: SBO:0000247
type: Species
is: HMDB01056
name: dihydrofolate(2-)

http://identifiers.org/biomodels.db/MODEL1310110041#_fc77eecc_02fc_4eb9_b60c_2294e97b285a
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: TXNRD1
is encoded by: hsa:7296
type: Species
constant: false
has only substance units: false
is: Q16881
is: SBO:0000252

metaR P5CRm
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
name: pyrroline-5-carboxylate reductase (m)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_3a45b86b_a480_4bbc_ad22_54a537347f0b
name: DHCR24
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1718
is: SBO:0000252
constant: false
is: Q15392
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_0a2e38d3_7421_4fb3_851a_3ecb28438222
is: SBO:0000252
is encoded by: hsa:64080
type: Species
initial amount: NaN
initial concentration: NaN
name: RBKS
has only substance units: false
constant: false
is: Q9H477
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_0025557e_36f4_4dbc_8b3e_e8afad7d3359
boundary condition: true
is encoded by: hsa:8704
name: B4GALT2
is: SBO:0000252
is: O60909
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR URAt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
reversible: true
name: uracil transport via facilated diffusion
is: SBO:0000185
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR ACt2m
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
is: HMDB00304
boundary condition: false
is: CHEBI:57847
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_13e83d61_89f5_4c0e_84ff_72ccfe21ee9e
name: SLC22A5
is encoded by: hsa:6584
type: Species
initial concentration: NaN
is: O76082
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM datp n
name: dATP
is: C00131
initial amount: NaN
has only substance units: false
is: CHEBI:61404
constant: false
type: Species
is: HMDB01532
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247

metaM ebastineoh r
has only substance units: false
is: C00526
name: hydroxylated ebastine
notes: FORMULA: C32H39NO3 CHARGE: 0
is: SBO:0000247
is: CHEBI:16450
is: HMDB00012
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaR r0281
type: Reaction
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is: SBO:0000176
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:

metaM ksi pre2 g
type: Species
constant: false
is: HMDB00175
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 2

metaR SO4HCOtex
reversible: false
type: Reaction
modifier: MODEL1310110041#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: sulfate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
product: MODEL1310110041#

metaM ksi deg4 l
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: CHEBI:57737
is: HMDB00868
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 4
has only substance units: false
boundary condition: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM q10h2 e
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB13111

metaR r0630
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110041#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_3958ad4c_1ce3_46a3_be07_f5c4d8d1dac4
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:8871
has only substance units: false
is: SBO:0000252
is: O15056
name: SYNJ2
initial concentration: NaN

metaR DURAD2
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: true
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110041#
name: dihydrothymin dehydrogenase (NADP)
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaM dgsn c
name: Deoxyguanosine
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
boundary condition: false
has only substance units: false
is: C00330
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB00085

metaR DGTPtn
product: MODEL1310110041#
name: dGTP diffusion in nucleus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
type: Reaction

metaM thyox L c
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:18332
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_fe8bd5ab_3966_4610_b710_e1d6ecb96bc4
is encoded by: hsa:257068
name: PLCXD2
has only substance units: false
boundary condition: true
is: Q0VAA5
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM xol25oh r
type: Species
name: 25-hydroxycholesterol
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:42977
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: HMDB06247
boundary condition: false
constant: false

metaM h m
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: C00080
name: proton
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c125b3e4_0255_42f9_a8cf_83b02331f2bb
name: NDUFA12
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55967
type: Species
is: F8VQS7
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_868660b3_f895_4fe6_b46c_7b7546ddcf01
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:767
name: CA8
has only substance units: false
is: P35219

metaR UGT1A10r
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.17
modifier: MODEL1310110041#
is: SBO:0000176
reversible: true
is described by: ECO:0000134
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal

metaR PROSTGF2t
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269
fast: false
name: prostaglandin uniport

metaR FAOXC180
reversible: false
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
product: MODEL1310110041#
fast: false

metaM CE2705 c
initial amount: NaN
is: CHEBI:36781
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: quinonoid dihydrobiopterin
type: Species

metaR r1650
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_b02ed69f_18d0_4588_8063_add575d5e256
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:113026
constant: false
has only substance units: false
is: Q8N3E9
name: PLCD3
initial concentration: NaN
boundary condition: true

metaM HC01162 c
type: Species
initial concentration: 1.0
is: CHEBI:58376
has only substance units: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_30870912_40f2_4569_ae83_a93de42dae7b
initial concentration: NaN
constant: false
name: RHBG
type: Species
is: Q9H310
has only substance units: false
boundary condition: true
is encoded by: hsa:57127
initial amount: NaN
is: SBO:0000252

metaR PROSTGD2t
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport

metaM h l
is: C00080
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:24636
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton

http://identifiers.org/biomodels.db/MODEL1310110041#_c5b17ac9_7eba_4da9_a160_09541cc206bb
initial concentration: NaN
name: GMDS
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:2762
initial amount: NaN
is: O60547
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_9b307a1c_ab1e_4c04_9788_fd481de62c06
initial concentration: NaN
is: Q9NVE7
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:55229
name: PANK4
boundary condition: true
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM q10h2 c
boundary condition: false
initial concentration: 1.0
name: Ubiquinol-10
is: SBO:0000247
is: HMDB13111
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM ksi deg36 l
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: HMDB00143
name: keratan sulfate I, degradation product 36
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110041#_779fb372_e40f_44ff_acea_368533064ce8
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AI697028
name: _AI697028_1_m
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR BHBtm
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
fast: false
type: Reaction
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reactant: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#

metaR r2525
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
type: Reaction
reversible: true
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_55e9a83c_fd1e_4f03_aba5_132644a14901
has only substance units: false
is encoded by: hsa:1593
boundary condition: true
is: Q02318
initial concentration: NaN
name: CYP27A1
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ea232d81_3933_409a_b4b2_e253d6976129
is encoded by: hsa:5152
name: PDE9A
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR RE0512M
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
type: Reaction
name: RE0512
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110041#_d2bb6e8f_d57a_444e_ad76_7b793f7ebd7a
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:79053
initial amount: NaN
is: SBO:0000252
is: A6NDW6
constant: false
name: ALG8
boundary condition: true

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM thyox L e
initial amount: NaN
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
is: CHEBI:18332
boundary condition: false
name: L-thyroxine
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00248

metaR P4507B12r
is version of: http://identifiers.org/ec-code/1.14.13.100
is: SBO:0000176
notes: GENE_ASSOCIATION: (9420.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - substrates by similarity/analogy to hydroxylase reactions (literature notes NADH can often be used in place of NADPH)
product: MODEL1310110041#
name: oxysterol 7alpha-hydroxylase
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_07b6d5f7_d6b4_48d3_a189_70c68699a74c
name: FADS1
is: O60427
constant: false
is encoded by: hsa:3992
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_89d52720_4d7a_40b1_9fe5_ae0c03566149
name: PDE6D
is: SBO:0000252
is: O43924
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:5147
has only substance units: false
type: Species

metaR THBPT4ACAMDASE
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase

metaM ksi pre36 g
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 36
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28067
type: Species
notes: FORMULA: C247H394N17O210S11X CHARGE: -12

http://identifiers.org/biomodels.db/MODEL1310110041#_3398802e_ed30_421b_829e_2fa0d5153e68
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1345
name: COX6C
initial concentration: NaN
has only substance units: false
is: P09669
type: Species

metaM h n
has only substance units: false
boundary condition: false
is: CHEBI:24636
name: proton
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
is: HMDB00045
name: AMP
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:456215
initial amount: NaN
initial concentration: 1.0

metaR MMMm
name: methylmalonyl-CoA mutase
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is version of: http://identifiers.org/ec-code/5.4.99.2
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_5bb2de48_f9ca_4f15_bad2_e6a5e8ebe4ad
name: GGT2
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:728441
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_a309f897_d358_4c83_a7e1_c74163ec3808
constant: false
name: CDO1
is encoded by: hsa:1036
is: Q16878
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR RBK
is: SBO:0000176
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000304
name: ribokinase
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
modifier: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.15
type: Reaction

metaR r1088
kinetic law: MODEL1310110041#
name: Active transport
reversible: true
product: MODEL1310110041#
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#

metaR GUAt
is: SBO:0000185
modifier: MODEL1310110041#
name: Guanine transport
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110041#_c53b50f1_98d2_4871_9d56_a29139fc4e04
boundary condition: true
is encoded by: hsa:2235
name: FECH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: Q7KZA3
type: Species

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r2378
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
type: Reaction
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110041#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR BETALDHxm
reversible: false
reactant: MODEL1310110041#
fast: false
is: SBO:0000176
name: betaine-aldehyde dehydrogenase, mitochondrial
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
is described by: ECO:0000000
type: Reaction

metaR r1653
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#

metaM udpglcur r
boundary condition: false
name: UDP-D-glucuronate
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
is: C00167
has only substance units: false
is: CHEBI:58052
constant: false
is: HMDB00935

metaR PROt4 2 r
fast: false
product: MODEL1310110041#
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110041#
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110041#_1a6c00d9_a8f6_4a32_be41_fd2e7bb7b28e
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: MPST
is: P25325
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4357

metaM 13dampp c
type: Species
name: trimethylenediaminium
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00002
is: CHEBI:57484

metaM his L m
type: Species
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: L-histidine

http://identifiers.org/biomodels.db/MODEL1310110041#_779b15db_c064_4266_8d70_dd50eb89a44e
is encoded by: hsa:9045
boundary condition: true
initial concentration: NaN
is: P50914
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: RPL14
is: SBO:0000252

metaR MALSO4tm
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
type: Reaction
name: Malate:sulfate antiport, mitochondrial
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269

metaR G12MT2 U
reactant: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110041#
fast: false
is: SBO:0000176

metaM dadp c
is: CHEBI:57667
is: C00206
is: HMDB01508
is: SBO:0000247
name: dADP
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial concentration: 1.0
has only substance units: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_cc3b3b83_d40a_44dc_84c2_3c773c0b353e
name: PYCR1
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5831
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: P32322

http://identifiers.org/biomodels.db/MODEL1310110041#_231e413e_42ae_4970_989b_3bab73a0c133
is encoded by: hsa:51268
initial concentration: NaN
initial amount: NaN
name: PIPOX
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q9P0Z9

metaR r1593
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#

metaM cholate c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
initial amount: NaN
constant: false
is: CHEBI:29747
name: Cholate
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c82226c7_098a_48ca_952f_40e62cfa0a58
is: SBO:0000252
initial concentration: NaN
is: Q9Y673
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:29880
name: ALG5

metaR r2379
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_3df50130_becb_4b55_b414_cd2efc016cbc
is encoded by: hsa:4247
boundary condition: true
constant: false
name: MGAT2
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is: Q10469
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_eb6b2226_a8e7_4f38_8443_d4cc90522abc
type: Species
is encoded by: hsa:5723
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: PSPH
is: SBO:0000252
is: P78330

metaR RE0830C
fast: false
type: Reaction
name: RE0830
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_142030ea_d05a_410f_b4ca_187b8c583a8d
is encoded by: hsa:29968
name: PSAT1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR DPCOAtl
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: dephospho-CoA transport from lysosome via diffusion
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is described by: ECO:0000000

metaR r1654
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110041#_33f9e8e3_cffa_4907_a436_1a01f1d10978
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: _AA629629_1_m
initial concentration: NaN
is encoded by: hsa:AA629629

metaM lnlccoa c
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
initial concentration: 1.0
name: linoleic coenzyme A

metaM pheme e
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: Protoheme
constant: false
has only substance units: false
is: HMDB03178
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
is: C00032
boundary condition: false

metaM akg m
boundary condition: false
is: HMDB00208
is: CHEBI:16810
constant: false
initial concentration: 1.0
is: C00026
has only substance units: false
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_204417bf_6b05_4c0f_9e6b_ee4e75421470
is encoded by: hsa:38
initial amount: NaN
is: SBO:0000252
name: ACAT1
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: P24752
type: Species

metaR PE HSter
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
name: phosphatidylethanolamine scramblase
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaM gdp n
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
type: Species
is: HMDB01201
has only substance units: false
name: GDP(3-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
constant: false
initial concentration: 1.0
is: SBO:0000247
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:61648
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0

metaM nadph m
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
is: C00005
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110041#_276ec06e_02c3_4b3a_aab5_85fe7887942e
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O15357
type: Species
constant: false
has only substance units: false
is encoded by: hsa:3636
boundary condition: true
name: INPPL1

metaR r2376
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaR r1590
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR RE2999M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
type: Reaction
name: RE2999
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_64ac3719_ceb1_42c9_afcb_11753f08b62f
initial amount: NaN
name: SLC22A2
is encoded by: hsa:6582
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_3d0f9e92_798e_422e_8c30_0768765ba07e
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: CA4
is encoded by: hsa:762
is: SBO:0000252
initial concentration: NaN
is: Q6FHI7

metaM amp m
is: SBO:0000247
name: AMP(2-)
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
constant: false
is: CHEBI:456215
is: HMDB00045
boundary condition: false

metaR DCK1n
reactant: MODEL1310110041#
name: Deoxycytidine kinase, nuclear (ATP)
fast: false
is: SBO:0000176
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is described by: ECO:0000269
modifier: MODEL1310110041#
reversible: true
type: Reaction
kinetic law: MODEL1310110041#

metaM HC00822 e
is: SBO:0000247
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
name: Chitobiose
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:28681

http://identifiers.org/biomodels.db/MODEL1310110041#_2fc73c00_8500_47d6_9a75_e2eca5356da3
is: P23677
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3706
is: SBO:0000252
name: ITPKA
constant: false
type: Species
has only substance units: false

metaR AG13T2g
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaR LTA4H
is version of: http://identifiers.org/ec-code/3.3.2.6
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
type: Reaction
name: Leukotriene A-4 hydrolase
reactant: MODEL1310110041#
is described by: ECO:0000134
modifier: MODEL1310110041#

metaM ksi deg14 l
is: HMDB00143
name: keratan sulfate I, degradation product 14
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR r1651
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#

metaR r2521
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
fast: false
is: SBO:0000185
name: Utilized transport
type: Reaction
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_df60f1d7_dad3_422e_b5a0_7dead8de10ea
name: UCP2
initial amount: NaN
is: P55851
is encoded by: hsa:7351
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR HACD9m
is: SBO:0000176
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110041#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
kinetic law: MODEL1310110041#

metaM gdp m
name: GDP
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00035
is: CHEBI:58189
initial amount: NaN
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
type: Species

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
is: CHEBI:28095
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: 2-Amino-3-oxoadipate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_9c9f8667_2781_47a8_8612_ba3220156cc7
boundary condition: true
is: P28329
has only substance units: false
constant: false
is encoded by: hsa:1103
is: SBO:0000252
type: Species
initial amount: NaN
name: CHAT
initial concentration: NaN

metaM betald c
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
initial concentration: 1.0
is: CHEBI:15710
is: HMDB01252
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaM dhf c
has only substance units: false
initial amount: NaN
name: 7,8-Dihydrofolate
is: HMDB01056
is: SBO:0000247
is: C00415
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57451

metaM l2fn2m2masn g
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
constant: false
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C68H113N4O49X CHARGE: 0
has only substance units: false

metaR r2377
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_9b078ce2_f8bb_4b7b_a52a_792cf79b7d68
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: SOD1
is encoded by: hsa:6647
initial concentration: NaN
has only substance units: false
is: P00441

metaM ksii core2 deg6 l
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: CHEBI:12936
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 6
is: HMDB00143
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

metaR DOLPGT1 Uer
is version of: http://identifiers.org/ec-code/2.4.1.267
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110041#
reversible: false

metaR r1591
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
fast: false
reversible: true

metaM apoC m
name: Apocarboxlase (no lys residue)
is: CHEBI:32551
is: HMDB00182
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: XH CHARGE: 0
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaM cholate e
initial concentration: 1.0
is: HMDB00619
initial amount: NaN
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
name: Cholate
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR B3GALT5g
reactant: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 5
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110041#_48a8e900_d312_42fa_b28d_f6565c2150c7
is: Q9NZ20
name: PLA2G3
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:50487

metaR r1652
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_5da1a8ba_33ae_4eac_b3f8_efb4f47ac1a3
is encoded by: hsa:2720
is encoded by: hsa:4758
has part: P16278
has part: P10619
initial amount: NaN
has only substance units: false
initial concentration: NaN
has part: Q99519
has part: P34059
is: SBO:0000297
is encoded by: hsa:2588
type: Species
constant: false
is encoded by: hsa:5476
name: GALNS:GLB1:NEU1:CTSA
boundary condition: true

metaR NACDe
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR r2520
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaR SRTNtu
name: Serotonin uniport
reactant: MODEL1310110041#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110041#_c75e8657_bccc_409d_8ae4_509e295b9238
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8654
initial amount: NaN
constant: false
type: Species
is: G5E9C5
has only substance units: false
name: PDE5A

http://identifiers.org/biomodels.db/MODEL1310110041#_3a2d25b1_ff0e_4edf_b8a2_f63ba3971643
is: SBO:0000252
initial concentration: NaN
constant: false
is: E9PD84
name: PCYT1B
has only substance units: false
boundary condition: true
is encoded by: hsa:9468
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_722deb48_769b_46a3_9193_79f6b3906657
initial concentration: NaN
name: SLC26A9
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:115019
boundary condition: true
type: Species
is: Q7LBE3

metaM g3p c
is: C00661
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: http://identifiers.org/pubchem.compound/3930
is: HMDB01112
has only substance units: false
initial concentration: 1.0
is: CHEBI:58027
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: Glyceraldehyde 3-phosphate

metaR ACt2r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
product: MODEL1310110041#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
name: acetate reversible transport via proton symport
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ae72caac_55e7_4059_8917_c8e5ba0c9e41
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: Q8TCD5
name: NT5C
is encoded by: hsa:30833
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM retfa e
boundary condition: false
is: CHEBI:15963
name: fatty acid retinol
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
has only substance units: false
is: HMDB00508

metaM 3sala c
boundary condition: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
name: 3-Sulfino-L-alanine
is: C00606
initial concentration: 1.0
type: Species
is: CHEBI:61085
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_edf67f8f_e289_4c55_85c4_135f0c12f62f
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2629
is: B7Z5G2
has only substance units: false
initial amount: NaN
constant: false
name: GBA
is: SBO:0000252

metaM h e
is: SBO:0000247
is: CHEBI:24636
initial concentration: 1.0
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
constant: false
has only substance units: false
is: C00080
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380

metaM datp m
is: HMDB01532
is: CHEBI:61404
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
boundary condition: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_45d26a9d_150c_4160_8c54_a3c960d5e1b1
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27124
constant: false
name: INPP5J
is: SBO:0000252
type: Species

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: PTPATe
reversible: true
reactant: MODEL1310110041#
type: Reaction
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110041#_d67f4e63_8434_4bd9_aa63_401c8b93fb99
is: A8DPS7
has only substance units: false
is encoded by: hsa:5049
name: PAFAH1B2
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_3c262691_a8a3_4188_9823_831db42d5907
is: Q5QPH3
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACSS2
is: SBO:0000252
is encoded by: hsa:55902
constant: false

metaR FAOXC161802m
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110041#
reversible: false
fast: false

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_3126ae8d_a50f_4257_9b50_4d5148929cab
has only substance units: false
is encoded by: hsa:AI090874
type: Species
constant: false
initial amount: NaN
name: _AI090874_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_9eab2547_c441_4bc5_8377_b91f90830d0a
initial amount: NaN
is encoded by: hsa:5149
has part: B7Z9T9
initial concentration: NaN
constant: false
name: PDE6A:PDE6H:PDE6B
has part: P16499
boundary condition: true
is: SBO:0000297
type: Species
is encoded by: hsa:5145
has part: Q13956
is encoded by: hsa:5158
has only substance units: false

metaR r1622
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#

metaR AG13T10g
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110041#

metaR r2374
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
fast: false

metaM CE5854 e
has only substance units: false
constant: false
name: gama-CEHC-glucuronide
type: Species
initial amount: NaN
is: CHEBI:27485
is: SBO:0000247
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
boundary condition: false
initial concentration: 1.0
is: HMDB02710

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r1657
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_4afc7ec6_20e7_4180_ac2c_1ad1c17f0adb
initial concentration: NaN
name: MAT2B
has only substance units: false
is encoded by: hsa:27430
constant: false
is: Q9NZL9
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaM accoa c
initial amount: NaN
name: Acetyl-CoA
is: HMDB01206
constant: false
is: SBO:0000247
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57288

metaM 3odcoa m
name: 3-Oxodecanoyl-CoA
initial concentration: 1.0
is: HMDB03939
constant: false
is: CHEBI:28528
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial amount: NaN
is: SBO:0000247

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaM nadph r
is: HMDB00221
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
is: CHEBI:57783
is: C00005
initial concentration: 1.0

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:28276
has only substance units: false
name: (S)-Hydroxyhexanoyl-CoA
is: SBO:0000247
initial concentration: 1.0

metaR r1658
is: SBO:0000185
reversible: true
product: MODEL1310110041#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CERT2gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
reversible: true

metaR r2375
product: MODEL1310110041#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_0d6c1ab5_69b1_4bdb_ae73_f1219ea1091c
is: SBO:0000252
initial concentration: NaN
type: Species
name: DECR1
is encoded by: hsa:1666
boundary condition: true
constant: false
initial amount: NaN
is: Q16698
has only substance units: false

metaR r1621
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: true
fast: false
reactant: MODEL1310110041#
is: SBO:0000185

metaM ebastineoh c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00012
notes: FORMULA: C32H39NO3 CHARGE: 0
initial amount: NaN
boundary condition: false
is: C00526
is: SBO:0000247
is: CHEBI:16450
name: hydroxylated ebastine

http://identifiers.org/biomodels.db/MODEL1310110041#_b98e39c5_e0fb_4bbe_9cae_918dd3305f75
initial concentration: NaN
is: O00462
is encoded by: hsa:4126
has only substance units: false
type: Species
name: MANBA
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_d879cef4_caa5_4f02_b22f_885b39468c59
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P27708
name: CAD
is encoded by: hsa:790
type: Species

metaR GLYCTDle
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110041#
type: Reaction
name: difussion of glycerol accross the brush border membrane

http://identifiers.org/biomodels.db/MODEL1310110041#_18a0afe1_1b9a_40f1_8830_288a647552e3
has only substance units: false
is: A0S0A7
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4846
name: NOS3
constant: false

metaM h g
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:24636
type: Species
constant: false
name: proton

metaR CO2ter
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110041#
fast: false
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
name: CO2 endoplasmic reticular transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110041#_f5a948d1_f85d_435c_802e_d3e3b9a05700
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: _AU149534_1_e
has only substance units: false
is encoded by: hsa:AU149534

metaM tststerone r
has only substance units: false
initial concentration: 1.0
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
is: HMDB00234
constant: false
type: Species
boundary condition: false
is: CHEBI:17347
initial amount: NaN

metaR q10h2tc
is: SBO:0000185
reversible: true
name: transport of ubiquinol into cytosol
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_36267c98_9155_4795_b2c8_cc16694e43fe
is: SBO:0000252
is: Q96M32
is encoded by: hsa:122481
initial concentration: NaN
has only substance units: false
constant: false
name: AK7
boundary condition: true
initial amount: NaN
type: Species

metaM 2mop m
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
is: HMDB01172
type: Species
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaM ksi pre12 g
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00175
type: Species
is: CHEBI:58053
is: C00130
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 12
initial concentration: 1.0

metaR GLCt2 2
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: D-glucose transport in via proton symport
fast: false
reversible: true
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110041#

metaR BTNtn
type: Reaction
fast: false
name: Biotin transport, nuclear
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
product: MODEL1310110041#
reversible: true
is: SBO:0000185

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR GLYSNAT5tc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1655
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110041#
reactant: MODEL1310110041#

metaR r1620
modifier: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
product: MODEL1310110041#
type: Reaction

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM 4fumacac c
is: CHEBI:18034
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB01268
name: 4-fumarylacetoacetate(2-)

metaR r2372
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
fast: false

metaR ME2m
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
is described by: ECO:0000000
modifier: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.40
reactant: MODEL1310110041#
name: malic enzyme (NADP), mitochondrial
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM 20ahchsterol m
is: HMDB06283
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:1296
initial amount: NaN
name: 20-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1642b9e3_7cdc_47af_8a9d_deab5333c5a3
has only substance units: false
constant: false
is encoded by: hsa:8813
type: Species
name: DPM3:DPM1:DPM2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54344
has part: O94777
is: SBO:0000297
has part: O60762
boundary condition: true
is encoded by: hsa:8818
has part: Q86TM7

metaR NACHEXA19ly
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110041#
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176

metaR G14T15g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
product: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
reactant: MODEL1310110041#

metaM mi1p D c
is: CHEBI:58433
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
is: HMDB02985
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaR GLNS
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.1.1.15
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110041#
is described by: ECO:0000254
name: glutamine synthetase
product: MODEL1310110041#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e244e260_ee61_4cb6_b208_6e7d39fbbcf0
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:38
type: Species
name: ACAT1
boundary condition: true
is: P24752
initial amount: NaN
constant: false

metaM pheme c
boundary condition: false
constant: false
is: HMDB03178
name: Protoheme
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
initial amount: NaN
is: SBO:0000247
is: C00032
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_cbbd382d_716b_4e2c_a699_79a455608572
boundary condition: true
initial concentration: NaN
is: Q5QPH3
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:55902
type: Species
is: SBO:0000252
name: ACSS2

metaM ksi pre21 g
is: C00130
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 21
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8072c234_5f15_4df1_b95a_9fbe35a6a815
is encoded by: hsa:8310
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ACOX3
initial amount: NaN
type: Species
boundary condition: true
is: O15254
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_0986cd29_8c9b_4b58_9143_0750d1184395
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:26266
name: SLC13A4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9UKG4

http://identifiers.org/biomodels.db/MODEL1310110041#_4e2bca4a_2f3b_4c2a_9546_496cc158e026
type: Species
name: ACSL3
is: B3KMA6
is encoded by: hsa:2181
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r0345
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: true
is: SBO:0000176
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR r1656
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f24f0ded_58e9_43b6_8a97_ed9b35addc62
has part: O95498
name: VNN3:VNN2:VNN1
boundary condition: true
is: SBO:0000297
is encoded by: hsa:8875
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:55350

metaM ebastineoh e
is: HMDB00012
initial concentration: 1.0
name: hydroxylated ebastine
initial amount: NaN
has only substance units: false
is: C00526
notes: FORMULA: C32H39NO3 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: CHEBI:16450
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_39decd67_72c8_48c1_8582_15909c4b836a
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: _206_1_c
is encoded by: hsa:206
type: Species
boundary condition: true

metaR r2373
is: SBO:0000185
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: true
type: Reaction

metaR r0410
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110041#
is described by: ECO:0000000

metaM anth c
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:16567
name: anthranilate
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9f8b9495_37f8_4cd3_8ee6_b3eae4b0a216
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ALDH1A1
is encoded by: hsa:216
is: P00352
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR r2353
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaR LEUKTRB4t
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: leukotriene B4 transport

metaM nadh x
has only substance units: false
is: CHEBI:57945
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01487
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3306
is: C00004

metaM ahcys r
type: Species
is: HMDB00939
boundary condition: false
is: CHEBI:16680
name: S-adenosyl-L-homocysteine
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
constant: false

metaM pydx c
boundary condition: false
constant: false
type: Species
has only substance units: false
is: C00250
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: HMDB01545
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Pyridoxal
is: CHEBI:17310

http://identifiers.org/biomodels.db/MODEL1310110041#_1b3ec18c_0613_47fd_ba9f_37cd075fddcf
has only substance units: false
initial amount: NaN
name: SLC10A2
type: Species
constant: false
is encoded by: hsa:6555
boundary condition: true
is: Q12908
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_dc0460df_4859_4869_9b74_54cb4e1f04cf
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:H17063
boundary condition: true
constant: false
name: _H17063_1_c
initial amount: NaN
initial concentration: NaN

metaM glyc m
is: CHEBI:17754
is: C00116
name: Glycerol
is: HMDB00131
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species

metaR LEUt4
is described by: ECO:0000269
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
name: L-leucine transport in via sodium symport
reversible: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is: SBO:0000185
type: Reaction

metaR C204CPT2
fast: false
type: Reaction
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
name: arachidonic acid transport into the mitochondria
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000

metaM thp2c x
is: HMDB12130
is: SBO:0000247
is: CHEBI:16987
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
initial concentration: 1.0
name: 1-piperideine-6-carboxylate
constant: false

metaR r2352
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_765febd7_a4ad_4766_9747_5a6f19499657
boundary condition: true
type: Species
is encoded by: hsa:AW299740
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: _AW299740_1_m
initial concentration: NaN

metaM thr L c
has only substance units: false
is: CHEBI:16857
is: SBO:0000247
is: HMDB00167
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

http://identifiers.org/biomodels.db/MODEL1310110041#_f6160f69_f62c_4d6b_b06d_2130c2be5ba7
boundary condition: true
type: Species
is encoded by: hsa:125061
name: AFMID
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q63HM1
has only substance units: false
constant: false

metaM HC02180 c
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28728
has only substance units: false
name: thromboxane-b2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_2a1b614d_be70_4f60_802b_93f381844ddb
initial concentration: NaN
name: ACHE
is: SBO:0000252
is encoded by: hsa:43
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM gal c
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
name: D-Galactose
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00124
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:0
type: Species

metaR Coqe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110041#
type: Reaction
name: Transport of q10
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000134
fast: false

metaM mercplaccys c
initial amount: NaN
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
type: Species
is: HMDB06512
constant: false
boundary condition: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_26f215ad_afcc_4cfb_846d_c18168762a4b
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10935
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: PRDX3
is: E9PH29

http://identifiers.org/biomodels.db/MODEL1310110041#_fd07aabd_cb65_40a5_a523_4db4e66e93d2
has only substance units: false
name: ST3GAL3
is: Q11203
initial amount: NaN
is encoded by: hsa:6487
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM CE2705 n
type: Species
has only substance units: false
is: CHEBI:15374
is: HMDB02281
name: quinonoid dihydrobiopterin
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
initial amount: NaN

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR NCAMUP
name: Nicotinamide acid uptake
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_930816b0_b008_4af3_81bd_0c3721d62c80
initial concentration: NaN
has only substance units: false
name: VNN1
boundary condition: true
is: O95497
initial amount: NaN
is encoded by: hsa:8876
is: SBO:0000252
type: Species
constant: false

metaM fe2 e
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: C00023
boundary condition: false
is: HMDB00692
name: Fe2+
initial amount: NaN
is: CHEBI:29033

metaM dopa c
is: HMDB00073
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: CHEBI:59905
name: dopaminium(1+)
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM anth e
is: CHEBI:16567
has only substance units: false
constant: false
is: HMDB01123
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
type: Species
name: anthranilate

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_69955f16_c063_459e_997c_cfc06b07277a
is: SBO:0000252
type: Species
name: SLC6A10P
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:386757

http://identifiers.org/biomodels.db/MODEL1310110041#_302ab394_1251_4fa1_8af7_bec6abb0672e
initial amount: NaN
type: Species
is encoded by: hsa:8527
name: DGKD
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaR B3GNT310g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
reversible: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
is: SBO:0000176
is described by: ECO:0000254

metaM crn m
has only substance units: false
constant: false
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
initial amount: NaN
name: L-Carnitine
is: CHEBI:16347
is: SBO:0000247
type: Species
is: HMDB00062
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_50e07c46_c896_450e_95a4_4810cc134598
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:224
name: ALDH3A2
is: P51648

metaM ksi deg5 l
initial concentration: 1.0
constant: false
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
is: SBO:0000247
name: keratan sulfate I, degradation product 5

http://identifiers.org/biomodels.db/MODEL1310110041#_4f4a8740_16fc_486c_a648_26b9d5418783
type: Species
initial amount: NaN
boundary condition: true
is: A8K0I1
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:160851
name: DGKH
is: SBO:0000252

metaM dhea c
name: 3beta-hydroxyandrost-5-en-17-one
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
has only substance units: false
is: CHEBI:28689
is: HMDB00077
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2bef9cfd_dd83_4c38_84ee_204b24f0b079
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PDE9A

metaR r2355
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110041#
fast: false

metaM pydx e
is: SBO:0000247
name: Pyridoxal
initial amount: NaN
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
constant: false
type: Species
is: CHEBI:17310
boundary condition: false
initial concentration: 1.0
is: C00250
is: HMDB01545
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f4cbef23_fb6d_447c_b4c8_6a0c6aec4a1c
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC26A1
initial concentration: NaN
boundary condition: true
is: Q9H2B4
is encoded by: hsa:10861
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_49fa9aee_6e49_4584_ac33_87378691770a
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI024818
type: Species
has only substance units: false
name: _AI024818_1_c
initial amount: NaN
constant: false
is: SBO:0000252

metaM succ m
is: HMDB00254
initial amount: NaN
is: CHEBI:30031
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
boundary condition: false
name: Succinate
constant: false
is: C00042
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_fb799b12_4e5d_4485_a526_7e17b7a7d40f
type: Species
has only substance units: false
name: EHHADH
boundary condition: true
initial amount: NaN
is: Q9NY65
constant: false
is encoded by: hsa:1962
initial concentration: NaN
is: SBO:0000252

metaM thr L e
is: CHEBI:16857
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
is: HMDB00167

http://identifiers.org/biomodels.db/MODEL1310110041#_a83c14dc_acac_4a26_be87_773bb41b6c91
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: B4DG68
is: SBO:0000252
name: NOS1
boundary condition: true
is encoded by: hsa:4842

http://identifiers.org/biomodels.db/MODEL1310110041#_4c259328_c6af_4c11_b039_d31287a98dfc
is: SBO:0000252
is encoded by: hsa:23057
initial concentration: NaN
type: Species
constant: false
name: NMNAT2
initial amount: NaN
boundary condition: true
has only substance units: false

metaR 5OXPROt
name: Transport of 5-oxoprolinate
product: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110041#
fast: false

metaM 4abutn m
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
initial concentration: 1.0
is: HMDB01080
is: SBO:0000247
type: Species
name: 4-ammoniobutanal
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

metaR RE1517M
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
name: RE1517

metaR GARFT
type: Reaction
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
is: SBO:0000176
name: phosphoribosylglycinamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110041#
is described by: ECO:0000269

metaR TDCHOLAtx
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
fast: false
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_6215c029_34df_4220_9a86_7019ad940081
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CA6
boundary condition: true
type: Species
is encoded by: hsa:765
is: Q5FC00

metaM mercplaccys e
boundary condition: false
is: SBO:0000247
is: HMDB06512
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0
name: 3-mercaptolactate-cysteine disulfide
has only substance units: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_811119a0_3f93_44bf_bf46_8823f5791088
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:81539
boundary condition: true
type: Species
is: Q9H2H9
is: SBO:0000252
name: SLC38A1

metaR EX glgchlo LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-glycocholate complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_64e752e9_576a_44c9_b4b8_1c4741b9386c
initial amount: NaN
name: _AV717590_1_m
is encoded by: hsa:AV717590
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR FERO
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
reversible: false
is described by: ECO:0000134
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false

metaM ksi pre13 g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 13
type: Species
is: HMDB00175
initial amount: NaN
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: C00130
is: CHEBI:58053
constant: false

metaM fe2 c
has only substance units: false
initial amount: NaN
is: CHEBI:29033
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
constant: false
boundary condition: false
is: C00023
name: Fe2+
is: HMDB00692

http://identifiers.org/biomodels.db/MODEL1310110041#_68a58a10_e704_427d_b6e8_82290bd4f4a1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: TPK1
is encoded by: hsa:27010
type: Species
is: F5GZG6
constant: false

metaR r2354
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
product: MODEL1310110041#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00143
initial concentration: 1.0
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
constant: false

metaM pa hs c
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: phosphatidate(2-)
is: CHEBI:57739
has only substance units: false
boundary condition: false

metaM biocyt n
boundary condition: false
is: C05552
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
name: Biocytin
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: HMDB03134

metaM ppcoa c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
initial amount: NaN
name: Propanoyl-CoA
is: C00100
constant: false
is: HMDB01275
type: Species
has only substance units: false
is: CHEBI:57392

metaM q10 m
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01072
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
initial concentration: 1.0
type: Species
name: ubiquinone-10
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5c630ac7_ec97_4983_92cb_c01519097007
is encoded by: hsa:60482
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: SLC5A7
has only substance units: false
type: Species
is: Q9GZV3

http://identifiers.org/biomodels.db/MODEL1310110041#_cead8ceb_472c_40cf_9f38_a570ddd45ca3
initial concentration: NaN
is encoded by: hsa:112724
constant: false
type: Species
name: RDH13
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: B3KVA3

http://identifiers.org/biomodels.db/MODEL1310110041#_9ae130f3_1772_473e_9672_7698f200ab9a
is encoded by: hsa:36
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: P45954
name: ACADSB

http://identifiers.org/biomodels.db/MODEL1310110041#_8d990219_6558_4454_9dfe_82a57bb72b8b
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q8WUM9
is encoded by: hsa:6574
name: SLC20A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_1705e24b_7f01_4a9c_a310_c5f89fdf92bb
boundary condition: true
has only substance units: false
name: _AI915649_1_c
is encoded by: hsa:AI915649
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR 4HOXPACDOX NADP
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is: SBO:0000176
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000304
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction

metaR r1765
fast: false
kinetic law: MODEL1310110041#
reversible: false
product: MODEL1310110041#
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000

metaM ala L e
initial amount: NaN
is: HMDB00161
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:16977

metaM h2o c
boundary condition: false
is: C00001
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB02111
type: Species
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0
name: H2O
constant: false
is: CHEBI:3303

metaR CYTK13
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110041#
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_8bfac132_717d_4f11_bd95_de92fd6c4b43
has only substance units: false
type: Species
is encoded by: hsa:7001
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PRDX2

metaM gln L m
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: HMDB00641
initial concentration: 1.0
type: Species
is: CHEBI:18050
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_38964a80_6418_4d7f_b810_9a96c2546c46
is encoded by: hsa:3948
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: LDHC
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_06c40aea_ec10_4bdb_8cdc_4b358c53e7af
constant: false
name: _728637_1_c
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:728637

metaM biocyt m
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: Biocytin
constant: false
initial amount: NaN
initial concentration: 1.0

metaM btamp c
is: CHEBI:3110
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: Biotinyl-5'-AMP
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
is: SBO:0000247
is: HMDB04220
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_63ede8b5_611e_4348_8e9f_54896880fe37
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8706
is: B3KTQ4
name: B3GALNT1
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM leuktrD4 e
is: HMDB03080
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Leukotriene D4
is: SBO:0000247
type: Species
is: CHEBI:28666
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

http://identifiers.org/biomodels.db/MODEL1310110041#_d33a7b69_a1b2_4dc9_a721_1d3492a82d77
is encoded by: hsa:115019
is: B3KXK1
initial amount: NaN
boundary condition: true
name: SLC26A9
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r1921
modifier: MODEL1310110041#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false

metaM CE5788 e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
name: kinetensin 1-7
is: HMDB02710
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:27485
initial amount: NaN
type: Species

metaR CHLPCTD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.15
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
name: choline phosphate cytididyltransferase
product: MODEL1310110041#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110041#_bec7e345_5efe_4871_8c2e_85f5fbb90d53
name: DGKI
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:9162
constant: false
initial concentration: NaN
is: O75912

metaR CYTK14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110041#
reversible: true
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (dCMP,UTP)
product: MODEL1310110041#
type: Reaction

metaR VITD3t2
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
kinetic law: MODEL1310110041#
is: SBO:0000185
name: Vitamin D3 uptake
type: Reaction
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c5902b64_b80e_4132_a126_2c5a00cd4961
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AI601100
is: SBO:0000252
boundary condition: true
name: _AI601100_1_m
constant: false

metaM ksii core4 pre3 g
is: SBO:0000247
is: C00130
boundary condition: false
is: HMDB00175
type: Species
constant: false
name: keratan sulfate II biosynthesis, precursor 3
notes: FORMULA: C55H89N5O38X CHARGE: -1
has only substance units: false
initial amount: NaN
is: CHEBI:58053
initial concentration: 1.0

metaR ASCBt
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
name: L-ascorbate transport via facilitated diffusion
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110041#_1ed0fdd2_2c1e_460d_a19c_fd90845b95e0
has only substance units: false
name: ABO
constant: false
is: SBO:0000252
is encoded by: hsa:28
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P16442

metaM 5htrp c
is: HMDB00472
has only substance units: false
constant: false
is: CHEBI:17780
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
boundary condition: false
name: 5-hydroxy-L-tryptophan
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaR DNDPt17m
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
name: dUDP transport via dCDP antiport
product: MODEL1310110041#
reversible: false

metaM chsterol r
boundary condition: false
is: CHEBI:16113
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
type: Species
initial concentration: 1.0
is: HMDB00067

metaR RE1522M
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110041#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110041#
name: RE1522
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM so3 c
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00240
has only substance units: false
is: CHEBI:17137
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: Sulfite
constant: false
initial concentration: 1.0
is: C00094
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_38409d83_776d_447d_b9ba_5fbd29fb8189
type: Species
is encoded by: hsa:1120
is: Q9Y259
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: CHKB

metaR 1PPDCRp
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
is described by: ECO:0000000
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#

metaM 2oxoadp m
name: 2-oxoadipate(2-)
initial amount: NaN
is: HMDB00225
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57499

metaR r2532
reversible: true
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM dolglcp U r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15812
type: Species

metaM galthcrm hs g
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:26174
constant: false
name: Gal-Gal-Gal-Glc-Cer
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1175a703_6a08_4eff_b209_59a83ca637ca
initial concentration: NaN
is encoded by: hsa:2879
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
name: GPX4
type: Species
is: P36969
is: SBO:0000252

metaR DGK1
kinetic law: MODEL1310110041#
name: deoxyguanylate kinase (dGMP:ATP)
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
type: Reaction

metaR CHATn
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
initial amount: NaN
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
boundary condition: false
is: CHEBI:0
is: SBO:0000247
constant: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: HMDB00143
initial concentration: 1.0
is: C00124
has only substance units: false
type: Species

metaM ala L c
is: HMDB00161
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: L-alanine
is: CHEBI:16977
constant: false

metaR TRDR
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.8.1.9
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110041#
reversible: false
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
fast: false

metaR CYTK10n
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
name: cytidylate kinase (CMP,dGTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110041#_500bfa34_b7a6_40dc_97ca_70708df45b97
constant: false
type: Species
initial concentration: NaN
name: PDE5A
is encoded by: hsa:8654
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O76074

metaR r1512
type: Reaction
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: false
name: Utilized transport

metaR URIK1
name: uridine kinase (ATP:Uridine)
product: MODEL1310110041#
is described by: ECO:0000269
reversible: false
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.48

metaR RE3050R
is: SBO:0000176
name: RE3050
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_7b4cd986_1532_4bea_bff4_9670fd832588
is encoded by: hsa:6390
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is: P21912
boundary condition: true
type: Species
name: SDHB

metaM CE0785 m
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
type: Species
name: cis,cis-myristo-5,8-dienoyl-CoA
constant: false
has only substance units: false
is: C01936
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR RE3326M
name: RE3326
is: SBO:0000176
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:

metaR VITD3tm3
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
name: Vitamin D3 transport in mitochondria
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is transported from cytosol in mitochondria based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reversible: false
is: SBO:0000185

metaM dcyt n
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
boundary condition: false
is: CHEBI:15698
initial amount: NaN
name: 2'-deoxycytidine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00014

metaM nadh r
boundary condition: false
is: CHEBI:57945
type: Species
name: NADH(2-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: HMDB01487
is: SBO:0000247
initial amount: NaN
constant: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR FADH2ETC
is: SBO:0000176
name: Complex II reaction for respiratory chain
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110041#
fast: false

metaR NACHEXA20ly
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110041#
type: Reaction
reversible: false
reactant: MODEL1310110041#

metaM m2mn l
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB06537
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110041#_347a8ea9_2e19_4f5b_b0de_68337f78a295
name: B3GNT7
initial concentration: NaN
is: Q8NFL0
is: SBO:0000252
is encoded by: hsa:93010
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM dhlpro m
type: Species
initial concentration: 1.0
boundary condition: false
name: Dihydrolipolprotein
constant: false
is: CHEBI:16194
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM thf m
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
constant: false
is: HMDB01846
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: C00101
is: CHEBI:57453

metaM leuktrD4 c
initial amount: NaN
is: CHEBI:28666
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03080
name: Leukotriene D4
boundary condition: false

metaM HC01405 m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: SBO:0000247
is: CHEBI:28632
name: (S)-Hydroxyoctanoyl-CoA
constant: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_599ee1f8_09ed_40e3_bb74_895c18b3bad8
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _AV713053_1_m
is encoded by: hsa:AV713053
boundary condition: true

metaR LYStiDF
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-lysine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000269
fast: false
reversible: false

metaM gua c
initial amount: NaN
is: C00242
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: Guanine
boundary condition: false
is: CHEBI:16235
has only substance units: false
is: SBO:0000247
is: HMDB00132

metaM andrstrn r
initial amount: NaN
name: androsterone
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: CHEBI:16032
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: SBO:0000247
is: HMDB00031
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c87da0bf_90f0_4491_986a_3db02727f4a3
constant: false
is: SBO:0000252
name: PCYT1A
has only substance units: false
is: P49585
is encoded by: hsa:5130
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_913c1e6a_1426_4ca0_9a17_838b5d9c6f98
is: SBO:0000252
initial concentration: NaN
is: Q07837
is encoded by: hsa:6519
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: SLC3A1
boundary condition: true

metaM CE4790 m
boundary condition: false
initial amount: NaN
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:12947
initial concentration: 1.0

metaM xoltri27 r
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18431
constant: false
type: Species
is: HMDB06281
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1
name: 7alpha,26-dihydroxycholesterol

metaR RE2079R
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
fast: false
name: RE2079

http://identifiers.org/biomodels.db/MODEL1310110041#_ab49fc21_e31c_41ae_a2c1_eaa18b4dc0ba
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: NDUFB7
is encoded by: hsa:4713
is: P17568
initial amount: NaN
boundary condition: true

metaM h2o g
has only substance units: false
name: water
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: CHEBI:15377
initial concentration: 1.0
is: HMDB02111
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_449c479d_7f41_4499_a5f9_2b353d32ef6e
is: Q9BYG0
is encoded by: hsa:84002
type: Species
initial concentration: NaN
has only substance units: false
name: B3GNT5
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_8e406234_cf91_4ac8_af8e_5407c569291d
is encoded by: hsa:4724
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: O43181
constant: false
has only substance units: false
name: NDUFS4
initial concentration: NaN

metaR r0497
fast: false
modifier: MODEL1310110041#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_c748df2b_ae97_437d_8ff0_9a4e7499ac4f
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:115584
is: Q8WWX8
name: SLC5A11
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_e4a1b88e_4343_4766_b102_f6fb763e5a7c
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:224
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P51648
name: ALDH3A2

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
constant: false
type: Species
is: CHEBI:26174
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
initial concentration: 1.0
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false

metaM C02470 c
is: http://identifiers.org/pubchem.compound/5485
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial amount: NaN
is: HMDB00881
is: C02470
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: Xanthurenic acid
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_365e9bd8_edaa_4a15_b32f_d0a9b3c948a3
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:7378
name: UPP1
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_EX_acn13acngalgbside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sialyl (1,3) sialyl (2,6) galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR ECOAH12m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
reactant: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

metaM CE2251 c
boundary condition: false
type: Species
notes: FORMULA: C41H68N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H72N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h27-28,30,34-36,40,52-53H,4-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: CE2251
name: 3-oxoeicosanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:52327
initial concentration: 1.0
is: SBO:0000247

metaM sTn antigen g
name: sialyl-Tn antigen
notes: FORMULA: C19H30N2O13X CHARGE: -1
is: HMDB00224
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58190
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM HC00250 e
boundary condition: false
name: hydrosulfide
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919

metaM succ c
is: CHEBI:30031
name: Succinate
initial amount: NaN
is: HMDB00254
is: C00042
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_31c7051c_10f0_4b24_a37d_328c4fe26e27
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: Q8TD20
name: SLC2A12
has only substance units: false
boundary condition: true
is encoded by: hsa:154091

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR CO2tm
reactant: MODEL1310110041#
is described by: ECO:0000000
name: CO2 transport (diffusion), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
type: Reaction
fast: false

metaR r1873
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_e9eefe83_9ae9_498e_a570_e8209c022914
boundary condition: true
name: SLC25A5
constant: false
is: Q6NVC0
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:292
initial amount: NaN

metaM CE2417 m
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
boundary condition: false
is: HMDB11123
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: CHEBI:28387
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR r2535
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: true
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR GULN3D
fast: false
is described by: ECO:0000000
reversible: true
name: L-gulonate 3-dehydrogenase
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_344e3566_1387_45fc_ae2a_a77502b8da02
has only substance units: false
initial amount: NaN
name: _U37519_1_m
type: Species
is encoded by: hsa:U37519
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaM leugly e
boundary condition: false
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: SBO:0000247
initial amount: NaN
name: Leucylglycine

metaR NACHEX27ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reversible: false
modifier: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000269
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_157d2933_5007_48f0_8bae_d8df61dbda6e
constant: false
is: SBO:0000252
is encoded by: hsa:2990
initial concentration: NaN
boundary condition: true
type: Species
name: GUSB
has only substance units: false
initial amount: NaN
is: P08236

metaM h2o e
is: C00001
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:15377
initial concentration: 1.0
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111

metaR NACHEXA12ly
reversible: false
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_040c352d_34e1_42da_9e8f_5f1a14dcb006
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2348
is: SBO:0000252
has only substance units: false
name: FOLR1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_17f05ec9_1ffc_4613_8c98_ab7cf22293a2
is encoded by: hsa:79369
initial amount: NaN
is: SBO:0000252
is: Q9C0J1
type: Species
name: B3GNT4
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR r2120
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM C02528 r
name: chenodeoxycholate
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
is: CHEBI:36234

http://identifiers.org/biomodels.db/MODEL1310110041#_4b429289_1469_4ef4_affb_bb17dbeb4a3d
initial amount: NaN
is encoded by: hsa:5048
type: Species
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
has only substance units: false
boundary condition: true
has part: P43034
is: SBO:0000297
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_86dd9275_38c4_4200_b717_4b01c6ae66fe
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:79087
name: ALG12
is: Q9BV10
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_1b1b93d9_816b_42ff_954d_9721fb43199d
name: SUOX
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6821
is: P51687
boundary condition: true
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_62d6cbef_b8b1_49e0_8f32_1ea4910e86d6
initial amount: NaN
is: Q53Y41
has only substance units: false
boundary condition: true
name: DDC
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1644

metaR PA HSter
kinetic law: MODEL1310110041#
name: phosphatidate scramblase
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000

metaM acac c
boundary condition: false
initial amount: NaN
name: acetoacetate
is: SBO:0000247
is: HMDB00060
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_58d0a69b_53f0_49ec_996f_3378459cf15d
constant: false
name: DAD1
boundary condition: true
initial amount: NaN
is: Q53G02
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:1603
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_4d1b36a1_24a3_4802_8674_42102abf06d2
initial concentration: NaN
constant: false
type: Species
is: O43570
is encoded by: hsa:771
name: CA12
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR PHCDm
reactant: MODEL1310110041#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
kinetic law: MODEL1310110041#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000304

metaR P5CDm
is described by: ECO:0000269
fast: false
product: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
reactant: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false

metaR r2121
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR SIAASE3ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_f9ac3ab6_928c_42e8_83b6_7a6407dc950c
constant: false
name: FECH
has only substance units: false
is: P22830
boundary condition: true
type: Species
is encoded by: hsa:2235
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR GLCAASE9ly
is described by: ECO:0000269
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
product: MODEL1310110041#
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110041#

metaM lnlncgcoa c
type: Species
initial concentration: 1.0
is: CHEBI:57363
boundary condition: false
is: HMDB06368
constant: false
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaM fuc12gal14acglcgalgluside hs g
is: SBO:0000247
is: HMDB00304
constant: false
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
name: Type IIH glycolipid
has only substance units: false
is: CHEBI:57847
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_2d4d2d5d_21e0_4487_9333_6264cbe9c36c
is: O43677
has only substance units: false
is encoded by: hsa:4717
type: Species
name: NDUFC1
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR r2537
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
name: Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_eed62b28_bb92_4247_9a94_c1eec0afb387
has only substance units: false
initial concentration: NaN
is: O75874
type: Species
initial amount: NaN
is encoded by: hsa:3417
is: SBO:0000252
boundary condition: true
constant: false
name: IDH1

metaR RE3566C
kinetic law: MODEL1310110041#
is: SBO:0000176
name: RE3566
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
reactant: MODEL1310110041#

metaR r1492
reactant: MODEL1310110041#
fast: false
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction

metaM sucsal m
is: HMDB01259
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
name: Succinic semialdehyde
is: CHEBI:57706

metaM dctp n
is: SBO:0000247
is: C00458
is: HMDB00998
initial amount: NaN
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16311
type: Species
boundary condition: false

metaM bhb m
is: HMDB00011
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
is: SBO:0000247
type: Species
name: (R)-3-hydroxybutyrate
has only substance units: false
boundary condition: false
is: CHEBI:10983
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_0865c139_0d17_4015_8695_544a55f6501b
name: MAT1A
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: Q00266
is encoded by: hsa:4143
constant: false

metaR TMDK1m
reversible: false
kinetic law: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
name: thymidine kinase (ATP:thymidine)
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
modifier: MODEL1310110041#
fast: false
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.21

http://identifiers.org/biomodels.db/MODEL1310110041#_ceb602db_065b_45fa_aecb_6f7acbede582
is: Q9BVK2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ALG8
constant: false
is encoded by: hsa:79053
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_e514e86d_e1a5_4dd7_a525_23ac48189a18
constant: false
name: SLC24A4
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:123041

http://identifiers.org/biomodels.db/MODEL1310110041#_9c3b3131_9440_4476_8fcb_0721957be2d1
is encoded by: hsa:100287639
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: _100287639_1_c
constant: false
initial concentration: NaN
initial amount: NaN

metaR PROD2m
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
name: Proline dehydrogenase (m)
reversible: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.99.8
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_66bec932_4f7c_4cff_bdaf_5112bd608298
constant: false
has only substance units: false
initial amount: NaN
is: H0UI06
type: Species
name: COX7A2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1347

metaM lpro m
has only substance units: false
boundary condition: false
is: CHEBI:15804
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
name: Lipoylprotein
type: Species
initial amount: NaN
constant: false

W3 CDTF: Thu Aug 30 16:42:52 BST 2012

metaR ACACt2
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
kinetic law: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
name: acetoacetate transport via proton symport
type: Reaction
reversible: true
is: SBO:0000185

metaM ahcys m
initial concentration: 1.0
is: SBO:0000247
is: C00021
initial amount: NaN
has only substance units: false
name: S-Adenosyl-L-homocysteine
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
constant: false
type: Species
is: CHEBI:16680

metaR RE1448N
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
reversible: true
is: SBO:0000176
name: RE1448

metaR GLCNACPT U
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.15
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_b21e032e_f624_46b6_8819_151a25553bdc
type: Species
is: P17174
is encoded by: hsa:2805
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GOT1
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9069f66e_c8c8_4482_a2a6_abd06f9a2e62
is: SBO:0000252
initial concentration: NaN
name: ACP1
is encoded by: hsa:52
has only substance units: false
constant: false
initial amount: NaN
is: Q59EH3
type: Species
boundary condition: true

metaM dopa e
is: HMDB00073
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
is: CHEBI:59905
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

metaR r2122
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR LEUGLYHYc
name: hydrolysis of leucylglycine
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:26174
boundary condition: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
constant: false
type: Species

metaR r2123
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: true
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR r0494
is: SBO:0000176
reactant: MODEL1310110041#
reversible: true
type: Reaction
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
fast: false

metaM 6pgl r
is: CHEBI:57955
is: HMDB01127
type: Species
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaM nadh m
initial amount: NaN
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
is: CHEBI:57945
constant: false
is: C00004
initial concentration: 1.0
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247

metaM h2o l
name: water
is: CHEBI:15377
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaM thf c
type: Species
is: CHEBI:57453
is: SBO:0000247
is: C00101
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
initial amount: NaN
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
boundary condition: false

metaM n2m2masn g
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial amount: NaN
has only substance units: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
boundary condition: false
constant: false
is: C11530
is: SBO:0000247
initial concentration: 1.0
type: Species

W3 CDTF: Thu Aug 30 16:42:52 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110041#_b6c949a5_7e16_4a45_b719_e41db8eee825
name: SLC25A14
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:9016
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_041ac3fb_c79f_430a_81bb_d738d7395bd3
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1103
name: CHAT
boundary condition: true
type: Species
is: Q6LEN5
constant: false

metaR FE2DMT1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4891.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
fast: false
modifier: MODEL1310110041#
name: uptake of food iron by DMT1 transporter
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
kinetic law: MODEL1310110041#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_5141f38f_e584_4c40_a6a6_5aa4a88d0a7b
initial concentration: NaN
is encoded by: hsa:4722
name: NDUFS3
boundary condition: true
is: SBO:0000252
is: O75489
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_4c03410b_14fa_4f64_9478_9cbe9473c891
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110041#_b06fcfbc_2e34_4752_a4fc_a365c6287304
has only substance units: false
constant: false
initial concentration: NaN
is: Q02221
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: COX6A2
is encoded by: hsa:1339

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR DCTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
type: Reaction
reversible: true
name: dCTP diffusion in nucleus

metaR PPCDC
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: phosphopantothenoylcysteine decarboxylase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.36
type: Reaction
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_db32f733_e9c1_46c6_a92f_fcbc178136ea
has only substance units: false
is: SBO:0000252
is encoded by: hsa:205
name: AK4
initial concentration: NaN
initial amount: NaN
type: Species
is: P27144
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_209e0055_b900_451c_9b65_d75df9062781
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:AI440329
name: _AI440329_1_r
initial amount: NaN
initial concentration: NaN

metaM ksi pre31 g
is: HMDB00175
is: CHEBI:58053
constant: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 31
has only substance units: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM itaccoa m
is: HMDB03377
name: itaconyl-CoA(5-)
has only substance units: false
is: CHEBI:57381
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
type: Species
initial amount: NaN

metaM chsterol m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00067
initial concentration: 1.0
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
is: SBO:0000247

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false

metaM glyclt x
is: HMDB00115
is: CHEBI:29805
initial concentration: 1.0
initial amount: NaN
name: glycolate
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a67b3d97_ab7e_46f8_918f_d350f0daa473
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4882
initial amount: NaN
name: NPR2

metaR DHORD9
reversible: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.3.5.2
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
fast: false
name: dihydoorotic acid dehydrogenase (quinone10)

http://identifiers.org/biomodels.db/MODEL1310110041#_28ea6c3e_299e_4cfa_b112_cc245da8a970
initial amount: NaN
type: Species
constant: false
is: O95477
is encoded by: hsa:19
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ABCA1
boundary condition: true

metaR RE1796M
name: RE1796
is: SBO:0000176
product: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.145
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_15de282c_70e1_4bf9_9d3b_e73d73d92cc8
constant: false
initial amount: NaN
boundary condition: true
name: _BF195998_1_x
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:BF195998
has only substance units: false

metaR TRIODTHYt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
kinetic law: MODEL1310110041#
name: T3 transport via facilitated diffusion
is described by: ECO:0000269
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
modifier: MODEL1310110041#
type: Reaction

metaR GHMT2r
reactant: MODEL1310110041#
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
type: Reaction

metaM chsterol l
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16113
constant: false
name: cholesterol
initial amount: NaN
has only substance units: false
boundary condition: false

metaR FE2tm
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
fast: false
type: Reaction
kinetic law: MODEL1310110041#
name: iron (II) transport
is: SBO:0000185

metaM ksii core2 deg5 l
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 5
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
type: Species

metaR r2125
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_e918a0ca_6640_4058_aebf_32b67581733d
is encoded by: hsa:AI824319
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI824319_1_r

metaM 2oxoadp c
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
type: Species
constant: false
is: HMDB00225
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 2-oxoadipate(2-)
is: CHEBI:57499

metaM cpppg3 c
is: HMDB01261
boundary condition: false
type: Species
name: Coproporphyrinogen III
has only substance units: false
initial amount: NaN
constant: false
is: C03263
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
is: CHEBI:57309

metaR DGAT
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
name: diacylglycerol acyltransferase
fast: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.20
reversible: false
modifier: MODEL1310110041#
type: Reaction
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000000

metaR RTOTAL3FATPc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaM 5fthf m
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB01562
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: CHEBI:57457
initial concentration: 1.0
is: SBO:0000247

metaM kynate c
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB00715
is: SBO:0000247
boundary condition: false
is: CHEBI:58454
name: kynurenate
initial amount: NaN

metaR r2420
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
is described by: ECO:0000000

metaR AICARte
fast: false
is described by: ECO:0000134
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

metaR FDH
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.6
reactant: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
fast: false
name: formate dehydrogenase
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110041#

metaM crn r
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16347
constant: false
has only substance units: false
boundary condition: false
is: HMDB00062
name: (R)-carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaM HC00250 c
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
initial amount: NaN
type: Species
name: hydrosulfide
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_42a5b008_24d3_4d45_88f0_ccbfab89ea40
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:6392
is: O14521
constant: false
name: SDHD

metaR r1400
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: false
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110041#_800f8de4_7075_43a0_b470_0d0d60a69b71
type: Species
name: PANK3
is encoded by: hsa:79646
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9H999
initial concentration: NaN
boundary condition: true

metaM 10fthf c
name: 10-Formyltetrahydrofolate
type: Species
is: C00234
is: CHEBI:57454
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
is: SBO:0000247
has only substance units: false

metaR G14T6g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reactant: MODEL1310110041#

metaM 42A3HP24DB c
is: http://identifiers.org/pubchem.compound/7956
is: SBO:0000247
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
has only substance units: false
is: C05645
is: HMDB04083
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

metaM HC01104 e
constant: false
name: 4-nitrophenyl phosphate(2-)
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: CHEBI:61146
is: SBO:0000247
initial amount: NaN

metaR GALASE7ly
modifier: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r0752
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
modifier: MODEL1310110041#
fast: false

metaR RE0944E
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#
name: RE0944
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_9bb0f46f_bc06_4cc4_ba83_018c1f145543
type: Species
is encoded by: hsa:125965
is: Q6YFQ2
has only substance units: false
name: COX6B2
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_21b013e2_a2cd_4b09_84ff_580cdd781ac2
has only substance units: false
initial amount: NaN
is: Q9Y6K8
initial concentration: NaN
name: AK5
constant: false
is encoded by: hsa:26289
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_1c5f5be5_616f_4b85_be35_dda10d31b780
has only substance units: false
is: Q13956
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5149
name: PDE6H
boundary condition: true
type: Species
is: SBO:0000252

metaR HSD3B12r
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
fast: false
is described by: ECO:0000134
product: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
reversible: false
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I

metaM dpcoa c
initial concentration: 1.0
has only substance units: false
is: CHEBI:57328
name: Dephospho-CoA
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
is: HMDB01373
is: C00882
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reversible: false
reactant: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9b1e4fa6_26a4_4c04_97ae_71e5864f1dec
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is: P36269
initial concentration: NaN
is encoded by: hsa:2687
has only substance units: false
name: GGT5

metaM ksi deg23 l
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00143
boundary condition: false
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
name: keratan sulfate I, degradation product 23
type: Species

metaR GGLUCT
kinetic law: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.4
is: SBO:0000185
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
product: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
name: gamma-glutamylcyclotransferase
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000269

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM ksii core2 pre2 g
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H63N3O28X CHARGE: -1
constant: false
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 2
is: CHEBI:58053
has only substance units: false
initial amount: NaN
is: C00130

metaR r2115
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110041#_7523643d_c10e_4cfb_beb5_95720f2f178a
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9BV79
initial concentration: NaN
boundary condition: true
name: MECR
has only substance units: false
is encoded by: hsa:51102
type: Species

metaM g3m8mpdol U r
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
type: Species
is: SBO:0000247
is: C05873
initial amount: NaN

metaR HXPRT
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_34034b3b_1617_4fb1_a450_7e6e44ddac3c
has only substance units: false
name: PEMT
is encoded by: hsa:10400
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r0753
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is: SBO:0000176
reactant: MODEL1310110041#
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM co c
name: carbon monoxide
is: CHEBI:17245
type: Species
is: HMDB01361
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237

metaR HDCAtr
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110041#

metaR It
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110041#
name: Iodide uniport
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_76b22f3d_afa9_4918_8f4d_535ad86c9727
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GGT1
initial amount: NaN
type: Species
is: P19440
is: SBO:0000252
is encoded by: hsa:2678
constant: false

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR MECOAS1m
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
name: mesaconate--CoA ligase (GDP-forming)
reversible: true
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110041#
is described by: ECO:0000304
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_2e5c32c0_40e2_4bf1_a039_85a6bdb7ca51
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: CS
boundary condition: true
initial amount: NaN
is encoded by: hsa:1431
is: SBO:0000252

metaR r0680
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
reactant: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

metaR r2114
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110041#
fast: false

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM hom L c
boundary condition: false
is: HMDB00719
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
type: Species
is: CHEBI:15699
has only substance units: false
initial amount: NaN
name: L-homoserine
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM ksii core4 deg3 l
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:12936
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
name: keratan sulfate II (core 4-linked), degradation product 3
is: SBO:0000247
is: HMDB00143

metaR LINOFATPtc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR r0246
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is: SBO:0000176
product: MODEL1310110041#
fast: false

metaR SUCD1m
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
modifier: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110041#
reversible: true
fast: false
name: succinate dehydrogenase

metaR G6Pter
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
reversible: true
kinetic law: MODEL1310110041#

metaR 7DHFtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
reversible: false
kinetic law: MODEL1310110041#
name: 7-glutamyl-DHF transport, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110041#

metaR ARACHDtr
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: intracellular transport
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR NAIt
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport

http://identifiers.org/biomodels.db/MODEL1310110041#_4100a670_3e1c_4388_819f_83767d057aa6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5860
type: Species
is: P09417
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: QDPR

http://identifiers.org/biomodels.db/MODEL1310110041#_149016e4_ccfe_468d_b011_a39eee1f4d89
initial amount: NaN
has only substance units: false
is: Q5T4Y1
is encoded by: hsa:6487
type: Species
boundary condition: true
name: ST3GAL3
initial concentration: NaN
constant: false
is: SBO:0000252

metaM dcyt c
initial concentration: 1.0
is: C00881
is: HMDB00014
initial amount: NaN
is: CHEBI:15698
name: Deoxycytidine
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
boundary condition: false
has only substance units: false

metaM aprgstrn c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB03069
name: (20S)-20-hydroxypregn-4-en-3-one
is: CHEBI:28453
constant: false
type: Species
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
is: SBO:0000247

metaR r0130
product: MODEL1310110041#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
is: SBO:0000176
reversible: true
type: Reaction

metaR NOt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
name: NO transport (diffusion)
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
reversible: true

metaM CE4872 c
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaM lald D c
initial amount: NaN
is: HMDB06458
initial concentration: 1.0
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
boundary condition: false
is: SBO:0000247
is: CHEBI:17167
has only substance units: false
type: Species
name: (R)-lactaldehyde

metaR r2117
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110041#
reactant: MODEL1310110041#

n:
  given: Ines
  family: Thiele

metaM co e
is: SBO:0000247
is: HMDB01361
constant: false
name: carbon monoxide
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
type: Species
is: CHEBI:17245

metaR r0245
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

metaM ppcoa m
is: CHEBI:57392
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB01275
has only substance units: false
name: Propanoyl-CoA
initial amount: NaN
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100
boundary condition: false

metaM ppi c
notes: FORMULA: HO7P2 CHARGE: -3
is: HMDB00250
is: CHEBI:0
is: C00013
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Diphosphate
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_1a43ae77_8453_42f8_8c3b_6cd61c1c93a3
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11001
type: Species
name: SLC27A2
boundary condition: true
is: O14975
has only substance units: false
constant: false
initial concentration: NaN

metaR r1918
kinetic law: MODEL1310110041#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_63055597_8d69_4c9c_ac7e_ae5fd1fbe499
is encoded by: hsa:51166
is: Q8N5Z0
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: AADAT

http://identifiers.org/biomodels.db/MODEL1310110041#_19c1ed44_aaa8_4e47_8cd4_5b9c757e52ce
is encoded by: hsa:5145
is: P16499
name: PDE6A
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR TPI
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000134
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical

metaR EX ebastineoh LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated ebastine exchange
type: Reaction

metaR ICDHyrm
product: MODEL1310110041#
is described by: ECO:0000269
name: Isocitrate dehydrogenase (NADP+)
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR PHYCBOXL
modifier: MODEL1310110041#
name: L-Phenylalanine carboxy-lyase
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000212
fast: false
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
kinetic law: MODEL1310110041#

metaM dutp m
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:17625
initial amount: NaN
type: Species
boundary condition: false
name: dUTP
is: HMDB01191
is: SBO:0000247

metaR r1919
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_38699d05_4759_4a5c_b474_a9f9110801dd
name: PLD2
type: Species
is: SBO:0000252
is encoded by: hsa:5338
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: O14939

metaM orn m
is: C01602
constant: false
is: CHEBI:46912
name: Ornithine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00214
boundary condition: false
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1

http://identifiers.org/biomodels.db/MODEL1310110041#_103b1509_8fba_46d1_a05a_ca183561cc27
constant: false
is: SBO:0000252
has only substance units: false
is: B4E3E9
initial concentration: NaN
is encoded by: hsa:4967
type: Species
name: OGDH
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_c9858ad7_5aff_476f_88cc_f7e9e198a976
is: Q9NYW8
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: RBAK
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:57786

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28607
type: Species
has only substance units: false
constant: false
name: CoproporphyrinogenI

metaM ksii core4 pre1 g
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II biosynthesis, precursor 1
constant: false
type: Species
boundary condition: false
has only substance units: false

metaR r2116
is described by: ECO:0000000
modifier: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM frdp c
has only substance units: false
is: CHEBI:175763
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: Farnesyl diphosphate
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: C00448

metaR BUTt2r
is: SBO:0000185
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
product: MODEL1310110041#
reversible: true
type: Reaction
name: Butyrate transport via proton symport, reversible
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_c49106bf_3364_47d0_80da_ada4a95bffdd
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: SLC6A7
is: Q99884
initial amount: NaN
boundary condition: true
is encoded by: hsa:6534

http://identifiers.org/biomodels.db/MODEL1310110041#_f48bb6d5_2d95_41a8_925c_b1266160f6cd
is encoded by: hsa:316
has only substance units: false
name: AOX1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: Q06278

metaR RE0691C
fast: false
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
name: RE0691
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM ser L c
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00187
name: L-serine

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: 1-piperideine-6-carboxylate
boundary condition: false
is: SBO:0000247
is: HMDB12130

metaM ksi pre3 g
initial concentration: 1.0
is: C00130
is: HMDB00175
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C93H152N6O67X CHARGE: -1
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 3
is: CHEBI:58053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
fast: false
name: blood group intracellular transport
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185

metaR TAGt
product: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
name: triacylglycerol transport

metaR HIStiDF
name: L-histidine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
product: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110041#
type: Reaction

metaM retinol cis 11 e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
name: 11-cis-retinol
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:16302
is: HMDB06216

metaM crn x
has only substance units: false
constant: false
name: L-Carnitine
is: HMDB00062
initial amount: NaN
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:16347
initial concentration: 1.0

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM dolglcp U c
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15812
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species

metaR r2119
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000

metaM udpgal g
name: UDP-D-galactose(2-)
initial amount: NaN
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58439
is: SBO:0000247
is: HMDB00302

metaM HC02149 m
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: O-Propanoylcarnitine
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:28867
is: SBO:0000247

metaM acac e
is: SBO:0000247
is: CHEBI:13705
has only substance units: false
name: acetoacetate
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_7c17f5fd_fc10_4756_96c8_7b3ab1e53f80
is: P10619
name: CTSA
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5476

metaM leuktrA4 e
initial concentration: 1.0
has only substance units: false
type: Species
name: leukotriene A4(1-)
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
is: CHEBI:57463
is: SBO:0000247
initial amount: NaN
is: HMDB01337

metaM aprgstrn e
is: HMDB03069
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28453
name: (20S)-20-hydroxypregn-4-en-3-one
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C04042
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN

metaR PEPCKm
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.32
name: Phosphoenolpyruvate carboxykinase (GTP)
modifier: MODEL1310110041#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_8888ad97_87ba_412a_a7eb_4e47fa659907
name: SLC2A14
is: SBO:0000252
is: Q8TDB8
initial concentration: NaN
is encoded by: hsa:144195
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM pap g
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
constant: false
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
is: CHEBI:58343
is: HMDB00061
initial concentration: 1.0

metaM icit c
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
type: Species
name: Isocitrate
has only substance units: false
is: C00311
initial concentration: 1.0
is: CHEBI:16087
constant: false
initial amount: NaN
is: HMDB00193

metaR r2118
is: SBO:0000185
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true

MODEL1310110041#
species: metaM 4abutn m
species: metaM nadp c
species: metaM pser L c
species: metaM ncam e
species: metaM o2s m
species: metaM ttdca c
species: metaM 5fthf m
species: metaM gthrd c
stoichiometry: 0.005829
species: metaM galgbside hs g
species: metaM oh1 e
name: DPM3:DPM1:DPM2
species: metaM sphs1p e
multipler: 1.0
species: metaM acgam c
species: metaM lac L c
species: metaM tym c
species: metaM 4hpro LT m
species: metaM 3aib D c
species: metaM chol e
species: metaM nadh c
species: metaM acngalgbside hs g
species: metaM glutcoa m
species: metaM HC01609 e
species: metaM HC01444 e
species: metaM CE4792 m
species: metaM HC02204 e
species: metaM pheme e
species: metaM biocyt e
species: metaM e4hglu m
species: metaM meoh e
species: metaM ctp m
species: metaM mi1p D c
species: metaM HC01522 c
species: metaM tcynt e
species: metaM asn L e
species: metaM dheas c
species: metaM 4mptnl c
species: metaM m4mpdol U r
species: metaM paf hs e
species: metaM ptth c
species: metaM hdca c
species: metaM pyr m
species: metaM thmmp m
species: metaM gal c
species: metaM HC01231 c
species: metaM apoC Lys btn c
species: metaM 25hvitd3 c
species: metaM duri c
species: metaM ksii core2 pre4 g
species: metaM CE5117 m
species: metaM lys L e
species: metaM m7masnC g
species: metaM dump c
species: metaM HC02180 e
value: 0.0
species: metaM gar c
species: metaM 3oddcoa m
species: metaM 1glyc hs e
species: metaM dgmp e
species: metaM xan c
species: metaM glc D c
species: metaM 3odcoa m
species: metaM ksi g
species: metaM pe hs e
species: metaM stcoa c
species: metaM Rtotal e
species: metaM zymst r
species: metaM abt e
species: metaM tsul c
species: metaM peamn c
species: metaM gln L c
species: metaM thm c
species: metaM lpro m
species: metaM ksi deg12 l
species: metaM ebastineoh e
species: metaM so3 m
species: metaM chsterol c
species: metaM octa c
species: metaM dolp U c

metaR MI1345PP
kinetic law: MODEL1310110041#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269

metaM Rtotal c
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16189
boundary condition: false
name: R total
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01448

metaR FUMAC
is: SBO:0000176
name: fumarylacetoacetase
kinetic law: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.7.1.2
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: false

metaR 7DHFtm
name: 7-glutamyl-DHF transport,m mitochondrial
reactant: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110041#

metaR MCLOR
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
name: 3-Mercaptolactate:NAD+ oxidoreductase
product: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_683c571f_ca1b_48f5_8f79_0952a865b1f6
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PLCH2
is: O75038
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:9651

metaM leugly c
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97364
boundary condition: false
name: Leucylglycine
is: SBO:0000247
notes: FORMULA: C8H16N2O3 CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0
type: Species

metaR r1050
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110041#
reversible: true
product: MODEL1310110041#
is: SBO:0000185
name: Vesicular transport
reactant: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_f8e4af9a_6cad_4c89_b0ff_93463b8d5e08
type: Species
is: P19404
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFV2
initial amount: NaN
is encoded by: hsa:4729
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_a3816d1c_df8a_4fae_afb5_c8be4c7690a2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O95470
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: SGPL1
is encoded by: hsa:8879

http://identifiers.org/biomodels.db/MODEL1310110041#_1ebadd6a_d223_41d5_981e_3f445d5abe58
type: Species
is: P09622
initial amount: NaN
boundary condition: true
is encoded by: hsa:1738
is: SBO:0000252
initial concentration: NaN
name: DLD
has only substance units: false
constant: false

metaR r0758
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM ser L e
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17115
is: HMDB00187
initial concentration: 1.0
type: Species
is: SBO:0000247
name: L-serine

metaM retinol cis 11 c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
initial amount: NaN
name: 11-cis-retinol
boundary condition: false
is: HMDB06216
has only substance units: false
is: CHEBI:16302
constant: false
is: SBO:0000247
type: Species

metaR PACCOAL
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: phenylacetate-CoA ligase
product: MODEL1310110041#

metaR ENGASE2ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM oaa c
is: CHEBI:3338
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
is: HMDB00223
name: Oxaloacetate
constant: false
type: Species
is: C00036
has only substance units: false

metaR r0242
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110041#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
reversible: true

metaM m1mpdol U c
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial concentration: 1.0
is: CHEBI:28067
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_20685d14_8f81_4702_92c6_567fe9ecb3e0
type: Species
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: BCKDHB
is: P21953

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110041#
type: Reaction
name: blood group intracellular transport
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: true

metaM dpcoa e
is: HMDB01373
name: Dephospho-CoA
constant: false
is: C00882
initial concentration: 1.0
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1a830aa2_3076_4a37_bc9e_c566d1df371a
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ACP2
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:53
is: E9PCI1

metaR RE2799C
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
name: RE2799
reversible: true
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
boundary condition: false
is: HMDB00304
name: Type IIIH glycolipid
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57847
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_1dcd5709_0b78_4bc0_aa15_d7d2033ea438
name: TPI1P2
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:286016
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR G14T18g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000000

metaR r1051
reactant: MODEL1310110041#
name: Vesicular transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185

metaM leuktrA4 c
has only substance units: false
initial amount: NaN
is: HMDB01337
name: leukotriene A4(1-)
type: Species
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
constant: false
is: CHEBI:57463
is: SBO:0000247
initial concentration: 1.0

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM ksii core2 pre1 g
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 1
is: CHEBI:28067
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaM cholcoa c
boundary condition: false
is: CHEBI:57373
initial concentration: 1.0
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
is: HMDB01374
initial amount: NaN
type: Species
name: choloyl-CoA(4-)
is: SBO:0000247

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR RE2069C
name: RE2069
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_7dd837a2_21df_434f_9a8c_278549a5c95e
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: SHMT1
constant: false
is: P34896
initial concentration: NaN
is encoded by: hsa:6470

http://identifiers.org/biomodels.db/MODEL1310110041#_46b2952f_51e1_4678_8da7_af4305c2550a
constant: false
name: IMPA2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:3613
is: O14732

http://identifiers.org/biomodels.db/MODEL1310110041#_49a448f7_61fc_4d62_9fe9_df6dd8b0f559
is encoded by: hsa:23517
initial concentration: NaN
name: SKIV2L2
is: SBO:0000252
constant: false
boundary condition: true
is: Q3MHC9
has only substance units: false
type: Species
initial amount: NaN

metaM nac e
has only substance units: false
name: Nicotinate
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: C00253
is: HMDB01488
is: CHEBI:0
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_7f5c9237_29eb_4795_b999_b6345feb5341
is: P48735
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:3418
name: IDH2
has only substance units: false
initial amount: NaN

metaR r2058
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
is: SBO:0000185

metaM ksii core4 pre2 g
initial amount: NaN
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial concentration: 1.0
name: keratan sulfate II boisynthesis, precursor 2
type: Species
is: CHEBI:58053
is: C00130
is: SBO:0000247
is: HMDB00175
boundary condition: false
has only substance units: false
constant: false

metaR DRIBt
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110041#
fast: false
name: deoxyribose transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_e9feabed_1983_4edb_a5a5_63755ffcbdf9
is encoded by: hsa:10999
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: SLC27A4
boundary condition: true
is: Q6P1M0
is: SBO:0000252
type: Species

metaM Rtotal e
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: R total
constant: false
is: C00255
has only substance units: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:3554
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110041#_b8b26dac_cfcb_44d8_bc6e_1ada6cee6ed4
constant: false
initial amount: NaN
is encoded by: hsa:10423
boundary condition: true
type: Species
is: A8K3L7
name: CDIPT
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_98eced39_677f_4b69_bf9a_a44c1da3c9b9
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _T83654_1_c
initial concentration: NaN
is encoded by: hsa:T83654
type: Species

metaR S6T2g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM fe2 m
name: Fe2+
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:29033
constant: false
is: SBO:0000247
is: C00023
is: HMDB00692
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ae2377cc_4c14_44d7_84a9_d9849132e2ed
boundary condition: true
initial amount: NaN
is encoded by: hsa:1606
name: DGKA
initial concentration: NaN
constant: false
is: P23743
type: Species
is: SBO:0000252
has only substance units: false

metaR UNK3
kinetic law: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000000
name: 2-keto-4-methylthiobutyrate transamination
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
reversible: false
reactant: MODEL1310110041#
type: Reaction
fast: false

metaM pap c
is: HMDB00061
constant: false
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:58343
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaR 3DSPHR
product: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
name: 3-Dehydrosphinganine reductase
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.102
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_99cba9c8_c596_4f93_b057_ab2f59476b2c
constant: false
is encoded by: hsa:477
type: Species
name: ATP1A2
is: P50993
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM udpgal c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00302
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
is: CHEBI:58439
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaM arachcrn c
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
has only substance units: false
is: HMDB06460
constant: false
is: SBO:0000247
name: arachidyl carnitine
type: Species
boundary condition: false
initial concentration: 1.0

metaM dcdp m
initial concentration: 1.0
constant: false
is: CHEBI:58593
is: HMDB01245
name: dCDP(3-)
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaR r1596
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM 4abutn c
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: C00555
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
initial concentration: 1.0
is: HMDB01080
constant: false
name: 4-Aminobutanal
boundary condition: false

metaR r0027
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
product: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_1d635944_2855_4c05_8bbb_0c6b1a5d0709
initial concentration: NaN
name: _AI345944_1_m
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI345944
type: Species
constant: false
has only substance units: false
boundary condition: true

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM dutp c
is: HMDB01191
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
is: C00460
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17625
is: SBO:0000247
boundary condition: false
type: Species

metaM 10fthf m
type: Species
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57454
boundary condition: false
name: 10-formyltetrahydrofolate(2-)

http://identifiers.org/biomodels.db/MODEL1310110041#_0aacb13b_36dc_41b6_ba9b_84ef5e8d9cfe
is: G5E960
initial concentration: NaN
constant: false
name: PLCB3
initial amount: NaN
is encoded by: hsa:5331
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM 6pgc r
type: Species
name: 6-phosphonatooxy-D-gluconate
constant: false
is: CHEBI:58759
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01316

metaM tsul m
boundary condition: false
constant: false
has only substance units: false
is: HMDB00257
initial amount: NaN
type: Species
name: thiosulfate(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094

http://identifiers.org/biomodels.db/MODEL1310110041#_48be4ed2_9d48_4243_ad3e_2cd769a42a74
constant: false
type: Species
is encoded by: hsa:10449
boundary condition: true
is: P42765
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACAA2

metaM C02528 e
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
constant: false
is: CHEBI:36234
is: HMDB00518
boundary condition: false
name: chenodeoxycholate

metaM C02528 c
name: chenodeoxycholate
has only substance units: false
constant: false
type: Species
is: CHEBI:36234
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00518
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

http://identifiers.org/biomodels.db/MODEL1310110041#_a20f11c5_1759_4c2a_8f63_04407a77d5b6
name: CHAT
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
constant: false
initial amount: NaN
is: SBO:0000252
is: D3DX95
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_79a8b324_3e1c_4072_968e_683bce7b0c17
boundary condition: true
is encoded by: hsa:6514
initial amount: NaN
is: SBO:0000252
name: SLC2A2
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: P11168

http://identifiers.org/biomodels.db/MODEL1310110041#_1e039520_49ab_44eb_881a_38e60a4f5fac
name: SLC25A26
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:115286
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_9b241d0f_4134_406d_a23d_c4ae8e9031fd
is: O75874
initial amount: NaN
name: IDH1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3417
constant: false

metaM dpcoa l
initial amount: NaN
constant: false
has only substance units: false
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
boundary condition: false
type: Species
is: HMDB01373
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0

metaM gal l
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
name: D-galactose
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c751d8c2_ee72_4b7f_900b_270c3d3462b2
initial amount: NaN
is encoded by: hsa:84532
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9NUB1
name: ACSS1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2fb8998f_c5dd_4024_939b_0664b27ab76b
has only substance units: false
is encoded by: hsa:8639
is: Q16853
name: AOC3
boundary condition: true
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaR r0688
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reversible: true
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
product: MODEL1310110041#

metaM dhap c
name: Dihydroxyacetone phosphate
is: C00111
is: http://identifiers.org/pubchem.compound/3411
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01473
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57642
boundary condition: false

metaR r1597
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_230c5ded_5486_429d_851b_bff04ccba6d0
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q70HW3
is: SBO:0000252
initial concentration: NaN
type: Species
name: SLC25A26
constant: false
is encoded by: hsa:115286

metaM nac c
type: Species
is: C00253
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:0
name: Nicotinate
is: HMDB01488
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_20f90f32_78e0_407f_bfb0_ea0d79bffc1e
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2544
constant: false
boundary condition: true
initial concentration: NaN
name: _2544_1_c

metaR MTHFD
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methylenetetrahydrofolate dehydrogenase (NADP)
fast: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000134
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#

metaM 10fthf7glu e
is: SBO:0000247
initial amount: NaN
constant: false
name: 10-formyltetrahydrofolate-[Glu](7)
initial concentration: 1.0
is: CHEBI:16236
is: HMDB00108
has only substance units: false
type: Species
notes: FORMULA: C50H57N13O25 CHARGE: -8
boundary condition: false

metaM HC00319 m
initial amount: NaN
type: Species
is: CHEBI:30794
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_c0871699_9cb2_45e9_bfa6_29e3f69a0aa8
has only substance units: false
initial concentration: NaN
name: OCRL
is: SBO:0000252
initial amount: NaN
is: Q01968
is encoded by: hsa:4952
boundary condition: true
constant: false
type: Species

metaM ficytC m
type: Species
constant: false
is: CHEBI:15991
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN
name: Ferricytochrome c
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_78c4053c_b37a_4aa8_800f_8ca1dc37aa1a
constant: false
is: SBO:0000252
is encoded by: hsa:10400
name: PEMT
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_b62ebd7e_cc9c_4c6a_a0b0_f2390ff0eca6
is: SBO:0000252
name: ATG9B
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: Q674R7
is encoded by: hsa:285973
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_371da3b6_4b9e_4736_a055_9b661d5e6b99
initial amount: NaN
name: MCEE
is encoded by: hsa:84693
is: Q96PE7
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_bea3548b_13e4_40fc_9abe_73221891e890
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:BG035985
name: _BG035985_1_c
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8ae48406_72b9_49b5_8043_e981fb2729e9
is encoded by: hsa:641649
name: TMEM91
is: C9JZ62
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_6758e9d6_5be0_4774_bab2_42807da304af
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6578
initial concentration: NaN
name: SLCO2A1
constant: false
has only substance units: false
boundary condition: true
type: Species
is: Q92959

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
fast: false
name: blood group intracellular transport
product: MODEL1310110041#
is described by: ECO:0000000

metaR r1594
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#

metaM udpgal e
name: UDP-D-galactose(2-)
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
boundary condition: false
initial amount: NaN
is: CHEBI:58439

http://identifiers.org/biomodels.db/MODEL1310110041#_dba2ca2d_e6cd_4e2b_aa4e_83c55d3beb86
has only substance units: false
is: P32929
is encoded by: hsa:1491
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: CTH

metaR LALDO
fast: false
reversible: true
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaR TSULt4 3
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reversible: true
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: thiosulfate transport via sodium symport
is described by: ECO:0000269
fast: false

metaM 4abutn e
constant: false
is: HMDB01080
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
initial concentration: 1.0
type: Species
name: 4-ammoniobutanal
is: CHEBI:58264
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ff15a9e5_0e49_4eb4_9575_07073bd08c58
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: SHMT1
is encoded by: hsa:6470

metaR FUT18g
is version of: http://identifiers.org/ec-code/2.4.1.69
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110041#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
product: MODEL1310110041#
type: Reaction
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176

metaR GLCAASE8ly
reversible: false
modifier: MODEL1310110041#
is: SBO:0000176
fast: false
name: beta-glucuronidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#

metaM 34dhoxpeg c
type: Species
is: HMDB00318
name: 3,4-Dihydroxyphenylethyleneglycol
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: C05576
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7902

metaM dcdp n
boundary condition: false
name: dCDP(3-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:58593

metaR S6T10g
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110041#
is described by: ECO:0000000

metaR DURIK1
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
type: Reaction
name: deoxyuridine kinase (ATP:Deoxyuridine)
is described by: ECO:0000254
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.21

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110041#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e21a592f_390f_4675_b30d_bff0bf0d1f2a
name: GART
initial amount: NaN
is: Q59HH3
constant: false
has only substance units: false
is encoded by: hsa:2618
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_51ec0cd5_1aed_4711_a470_27c50e720032
constant: false
initial concentration: NaN
is encoded by: hsa:6517
is: SBO:0000252
name: SLC2A4
type: Species
has only substance units: false
boundary condition: true
is: P14672
initial amount: NaN

metaM ksi deg32 l
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00143
type: Species
is: CHEBI:12936
name: keratan sulfate I, degradation product 32
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2

metaM dhap e
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01473
constant: false
is: CHEBI:57642
initial concentration: 1.0
name: glycerone phosphate(2-)
boundary condition: false

metaR r1595
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_48fa6e25_435d_42a7_81d7_a2ceb4fd631b
name: KDSR
is encoded by: hsa:2531
initial amount: NaN
has only substance units: false
is: Q06136
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_f4bb53e9_6b0f_49b7_87bb_08bd49745cfa
is encoded by: hsa:6391
constant: false
is: SBO:0000252
name: SDHC
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q99643
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_deed6932_95e6_498f_b611_8e78751bb8f1
initial amount: NaN
is encoded by: hsa:AA614647
type: Species
name: _AA614647_1_c
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR RBFK
reactant: MODEL1310110041#
name: riboflavin kinase
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.1.26
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110041#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ef282710_683a_46b4_b2e8_c82d33579308
is encoded by: hsa:5337
boundary condition: true
name: PLD1
constant: false
type: Species
is: Q59EA4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8c1ba0b9_1d38_4914_bcaa_acb6dd73f6d3
is encoded by: hsa:6531
name: SLC6A3
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q01959
boundary condition: true
initial concentration: NaN

metaR r2344
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: true

metaM Sfglutth c
name: S-formylglutathionate(1-)
type: Species
has only substance units: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN
boundary condition: false
is: CHEBI:57688
is: HMDB01550
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ec3ae9a4_7425_41dc_983f_d32d0416f517
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5330
constant: false
is: Q59F77
name: PLCB2
initial concentration: NaN
is: SBO:0000252

metaM 2dr5p c
type: Species
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01031
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
boundary condition: false
is: CHEBI:57651
initial concentration: 1.0

metaM oaa m
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00223
initial concentration: 1.0
name: Oxaloacetate
is: C00036
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
constant: false

metaR NACHEX25ly
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
modifier: MODEL1310110041#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110041#
reversible: false
product: MODEL1310110041#

metaR 2HCO3 NAt
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_553a3444_409a_4088_92fe_f6425a9c7cba
initial amount: NaN
type: Species
name: PPAP2C
has only substance units: false
boundary condition: true
is encoded by: hsa:8612
initial concentration: NaN
is: SBO:0000252
constant: false
is: E9PAY8

metaM acac m
is: CHEBI:13705
is: SBO:0000247
name: acetoacetate
type: Species
constant: false
initial amount: NaN
is: HMDB00060
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
boundary condition: false

metaR r1397
name: carnitine acetyltransferase EC:2.3.1.7
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaR THRGLYexR
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#

metaR r0986
reversible: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110041#
name: Vesicular transport

metaR AG13T13g
fast: false
product: MODEL1310110041#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r0683
kinetic law: MODEL1310110041#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reactant: MODEL1310110041#
reversible: false

metaM hom L e
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
is: HMDB00719
has only substance units: false
boundary condition: false
name: L-homoserine
initial amount: NaN

metaM biocyt e
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
is: SBO:0000247
is: C05552
has only substance units: false
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
is: HMDB03134
boundary condition: false
name: Biocytin
initial amount: NaN

metaM k c
has only substance units: false
initial amount: NaN
is: CHEBI:29103
boundary condition: false
is: HMDB00586
is: SBO:0000247
constant: false
is: C00238
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_5aea3492_0044_443f_b3df_019b0fade8fc
is encoded by: hsa:57835
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: SLC4A5

metaM HC02216 e
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
is: CHEBI:28922
initial amount: NaN
is: SBO:0000247

metaR CYTK8n
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP,dATP),nuclear
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110041#
reversible: true

metaR RE1845C
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reversible: true
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: RE1845

metaM q10 e
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
name: ubiquinone-10
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:46245
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01072

metaR r1396
fast: false
name: EC:2.3.1.21
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM doldp U r
type: Species
has only substance units: false
boundary condition: false
name: Dolichol diphosphate, human uterine homolog
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
constant: false
is: CHEBI:15750
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_4ef04f83_5d0d_408c_8b73_1ee6a860915d
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:9481
name: SLC25A27
initial concentration: NaN
is: F5GWR4
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM ala L m
type: Species
initial concentration: 1.0
name: L-alanine
is: HMDB00161
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
is: CHEBI:16977
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_affd4f86_08cd_498a_b367_3b386c7d9feb
has only substance units: false
type: Species
name: ST3GAL3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
boundary condition: true
is: B4DX62
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_0055c553_02c5_4469_858f_aa7bdd9bf910
constant: false
boundary condition: true
is encoded by: hsa:AI971036
initial amount: NaN
is: SBO:0000252
name: _AI971036_1_x
has only substance units: false
type: Species
initial concentration: NaN

metaM ppi e
name: Diphosphate
is: HMDB00250
has only substance units: false
is: CHEBI:33019
is: C00013
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0

metaR MM7Cbg
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110041#
product: MODEL1310110041#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

metaR r0987
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
fast: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_dff8d142_1200_4fbd_a104_91227a8cdc66
initial concentration: NaN
name: PFAS
has only substance units: false
initial amount: NaN
is encoded by: hsa:5198
is: Q6P4B4
boundary condition: true
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4580e1cf_f5f5_4bc9_b42d_b20312df329a
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: A0PJK1
name: SLC5A10
boundary condition: true
is encoded by: hsa:125206
type: Species

metaR r0021
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110041#_942b0525_6ebe_41d1_9fba_33060fc02757
is: P36269
name: GGT5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2687
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM so3 m
is: HMDB00240
is: CHEBI:17137
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
type: Species
is: SBO:0000247
name: hydrogensulfite

metaR r2346
fast: false
is: SBO:0000185
product: MODEL1310110041#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true

metaR PI45P5P
reactant: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR HMBS
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
reversible: false
is: SBO:0000176
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000254
name: hydroxymethylbilane synthase
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.61
product: MODEL1310110041#
fast: false

metaM gal e
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: D-Galactose
is: HMDB00143
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
is: C00124
boundary condition: false
is: CHEBI:0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_b7df2ff4_9add_47e1_b2e4_cec9b7b3ec20
constant: false
is: Q8N4A0
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8693
name: GALNT4
has only substance units: false
type: Species

metaR r0818
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
name: Transport reaction
reversible: false
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000

metaR TTDCAtr
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110041#
name: tetradecanoate (transport)
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110041#

metaR r0604
reversible: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
product: MODEL1310110041#

metaR MTHFC
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methenyltetrahydrofolate cyclohydrolase
fast: false
reversible: true
reactant: MODEL1310110041#

metaM dpcoa m
type: Species
initial concentration: 1.0
is: CHEBI:57328
has only substance units: false
initial amount: NaN
name: 3'-dephospho-CoA(2-)
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
is: HMDB01373
constant: false
boundary condition: false

metaR DOLGPP Uer
reversible: false
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110041#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110041#
is described by: ECO:0000000

metaR r1598
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
product: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_0517e361_06c1_4e5c_b693_b51533c4ee89
has only substance units: false
initial concentration: NaN
name: BTD
is: SBO:0000252
constant: false
is encoded by: hsa:686
type: Species
initial amount: NaN
boundary condition: true
is: P43251

metaM HC02180 e
is: CHEBI:28728
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: thromboxane-b2
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaR r2347
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_cbadccc5_8ed1_4bb3_90ea_476521322891
has only substance units: false
name: ST3GAL4
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6484
initial amount: NaN
is: Q6IBE6

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM biocyt c
initial amount: NaN
is: HMDB03134
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C05552
is: http://identifiers.org/pubchem.compound/7886
type: Species
name: Biocytin

http://identifiers.org/biomodels.db/MODEL1310110041#_3aaa33dd_fddd_4cdd_9f2a_fceb15f9322f
initial amount: NaN
type: Species
is encoded by: hsa:221823
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PRPS1L1
constant: false
initial concentration: NaN

metaM k e
initial amount: NaN
is: HMDB00586
is: CHEBI:29103
has only substance units: false
is: SBO:0000247
constant: false
is: C00238
boundary condition: false
name: potassium
type: Species
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM q10 c
name: ubiquinone-10
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: CHEBI:46245
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01072
is: SBO:0000247

metaM n2m2nm l
is: HMDB01356
initial amount: NaN
name: n2m2nmasn (w/o peptide linkage)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
constant: false
type: Species
is: CHEBI:57312

metaM icit m
name: Isocitrate
type: Species
is: HMDB00193
initial amount: NaN
is: CHEBI:16087
has only substance units: false
is: C00311
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaM HC02216 c
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f2beta
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaR GGH 10FTHF7GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reactant: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110041#_6b3d8b6d_a175_4880_a2a7_723de3f79490
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
initial concentration: NaN
name: PDE9A
has only substance units: false
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_aeb6c3e7_d7e1_4e10_a01b_a4ae4fb53aa4
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: P07864
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3948
name: LDHC

metaR GTHRDt
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
name: Glutathione transport into mitochondria
reactant: MODEL1310110041#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110041#
fast: false

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.12
fast: false
product: MODEL1310110041#
reversible: true
is described by: ECO:0000000

metaR ALOX5
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110041#

metaR r0817
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000185
fast: false

metaR r1599
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185
type: Reaction

metaR r0354
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110041#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reactant: MODEL1310110041#
name: acetyl-CoA C-acetyltransferase, mitochondrial
modifier: MODEL1310110041#
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
is: SBO:0000176
product: MODEL1310110041#

metaR r0022
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110041#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110041#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_2da582ec_bfdd_4db3_b2db_2017f06c0685
is: P43007
has only substance units: false
initial amount: NaN
name: SLC1A4
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6509
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_9d319a79_4c65_4560_a079_b0f595d40fb2
type: Species
boundary condition: true
is encoded by: hsa:R06874
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: _R06874_1_r
initial amount: NaN

metaR r0686
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110041#

metaR r1378
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR RE1447N
name: RE1447
kinetic law: MODEL1310110041#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_d19c28cc_9e03_45fc_b164_57cd322a6e1d
initial concentration: NaN
is encoded by: hsa:54675
is: Q9UJA2
boundary condition: true
constant: false
name: CRLS1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r0400
type: Reaction
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
kinetic law: MODEL1310110041#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_665194fe_3623_4728_a7ea_51a8c63a51f3
is: O95045
type: Species
name: UPP2
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:151531
has only substance units: false

metaR CLS hs
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
reversible: false
name: cardiolipin synthase (homo sapiens)
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false

metaM lnlncg l
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: gamma-linolenate
is: HMDB03073
constant: false

metaM adn c
name: Adenosine
is: C00212
is: CHEBI:16335
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
initial amount: NaN
constant: false
initial concentration: 1.0

metaM ksii core2 pre3 g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
constant: false
is: C00130
initial amount: NaN
is: CHEBI:58053
type: Species

metaR r2343
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110041#

metaM 3aib D c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: C03265
name: D-3-Amino-isobutanoate

http://identifiers.org/biomodels.db/MODEL1310110041#_3fabe0a8_3871_4914_aa0e_e87646adfa62
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O15305
name: PMM2
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5373
is: SBO:0000252

metaR CYOOm3
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
is described by: ECO:0000134
fast: false
name: cytochrome c oxidase, mitochondrial Complex IV
is version of: http://identifiers.org/ec-code/1.9.3.1
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is: SBO:0000185
product: MODEL1310110041#

metaM aps c
is: CHEBI:58243
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01003
is: SBO:0000247
boundary condition: false
constant: false
name: 5'-adenylyl sulfate(2-)
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
boundary condition: false
is: HMDB00973
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:43474
initial amount: NaN
constant: false

metaM nmn c
is: HMDB00229
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:14649
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
name: NMN
initial concentration: 1.0
is: C00455
boundary condition: false

metaM ksi deg9 l
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 9
is: SBO:0000247
is: HMDB00143
initial amount: NaN
notes: FORMULA: C188H301N13O166S10 CHARGE: -10

http://identifiers.org/biomodels.db/MODEL1310110041#_f198d558_c984_48a7_904c_5e0f61df9c64
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:6241
type: Species
name: RRM2
has only substance units: false
initial concentration: NaN
is: P31350

metaR EBP1r
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.5
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR 5ADTSTSTERONEte
is: SBO:0000185
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110041#
name: 5 alpha dihydrotesterone transport
fast: false
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000

metaM uri e
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
is: C00299
is: SBO:0000247
is: HMDB00296
constant: false
name: Uridine
initial concentration: 1.0
is: CHEBI:16704
boundary condition: false
type: Species
initial amount: NaN

metaR r0838
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
name: Free diffusion
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_d0da8834_72a5_4376_9870_f531afa959d5
initial concentration: NaN
type: Species
is encoded by: hsa:219
has only substance units: false
constant: false
boundary condition: true
is: P30837
is: SBO:0000252
name: ALDH1B1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_15c52c69_046e_40db_8dd6_480a686c4afb
name: HPD
is encoded by: hsa:3242
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B3KQ63

metaR Ser Thrtg
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
name: Ser/Thr transport (from golgi to lysosome)
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
fast: false
is described by: ECO:0000269

metaR r1750
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#

metaM glyc S c
has only substance units: false
initial amount: NaN
is: HMDB06372
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: (S)-Glycerate
notes: FORMULA: C3H5O4 CHARGE: 0
type: Species
is: CHEBI:33871

metaM biliverd c
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial amount: NaN
name: biliverdin(2-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57991
constant: false
is: HMDB01008
boundary condition: false
type: Species

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_5d2e255e_ca79_4877_bc52_795d4bb80978
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5138
type: Species
initial amount: NaN
name: PDE2A
is: SBO:0000252
is: Q8IW54
initial concentration: NaN

metaM ksii core2 g
boundary condition: false
is: HMDB02092
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: keratan sulfate II (core 2-linked)
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
is: CHEBI:17240
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_1f36586f_ebf5_4331_9b91_2c65a89012ab
is: SBO:0000252
name: GCNT4
has only substance units: false
type: Species
is encoded by: hsa:51301
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: Q9P109

metaR ACCOAtn
reactant: MODEL1310110041#
is: SBO:0000185
name: acetyl-CoA transport, nuclear
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_85f66a88_f968_4d6c_85bf_a7ef3f5c3630
has only substance units: false
name: SLC25A16
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:8034
type: Species
initial concentration: NaN
is: P16260
is: SBO:0000252

metaR G3PD1
reactant: MODEL1310110041#
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.8
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269

metaR r0839
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is: SBO:0000185
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.70

http://identifiers.org/biomodels.db/MODEL1310110041#_626b0b24_33c3_410d_91b1_4fe58f28a414
is: Q8IYH3
name: HAS1
is: SBO:0000252
is encoded by: hsa:3036
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR ABO7g
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is version of: http://identifiers.org/ec-code/2.4.1.37
reversible: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
product: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR INSTt2r
reversible: true
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
type: Reaction
name: inositol transport in via proton symport
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185
is described by: ECO:0000269

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r2341
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaM 4pyrdx e
initial concentration: 1.0
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
boundary condition: false
is: SBO:0000247
is: HMDB00017
is: CHEBI:30959
name: 4-pyridoxate
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reversible: true
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is: SBO:0000176
modifier: MODEL1310110041#

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR AG13T1g
type: Reaction
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
fast: false

metaM tsul c
is: HMDB00257
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
name: thiosulfate(2-)
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16094
initial amount: NaN
constant: false

metaR FPGS6m
fast: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.2.17
reversible: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000
name: folylpolyglutamate synthetase (DHF), mitochondrial
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM ksi pre27 g
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
name: keratan sulfate I biosynthesis, precursor 27
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
is: C00130
boundary condition: false

metaM pi e
name: hydrogenphosphate
boundary condition: false
constant: false
has only substance units: false
is: C00009
is: HMDB00973
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_9ac6e953_0531_4568_9d77_ddaca1a8c7eb
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI972237
name: _AI972237_1_c
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_0f622ab4_c5b6_41f5_a472_71cdb3da9d12
is: SBO:0000252
initial amount: NaN
name: LTA4H
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4048
type: Species
is: P09960
constant: false

metaR URIDK2m
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110041#
product: MODEL1310110041#
name: uridylate kinase (dUMP), mitochondrial
fast: false

metaR PMANM
is version of: http://identifiers.org/ec-code/5.4.2.8
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.2
name: phosphomannomutase

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM glyclt c
name: glycolate
constant: false
is: HMDB00115
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
type: Species
is: SBO:0000247

metaM thbpt c
initial concentration: 1.0
name: 5,6,7,8-tetrahydrobiopterin
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00027
constant: false
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial amount: NaN
type: Species

metaR r1377
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_bd17d969_01c8_4b79_8336_793d687dfa69
name: _AI191472_1_c
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI191472
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM tdcoa c
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
is: CHEBI:57385
is: C02593
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_c47324db_78e8_4d28_b0ae_8826abe59630
initial amount: NaN
name: SLCO1C1
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:53919
is: Q5JPA4
initial concentration: NaN
boundary condition: true

metaM tsul e
name: thiosulfate(2-)
is: SBO:0000247
constant: false
is: CHEBI:16094
is: HMDB00257
has only substance units: false
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
boundary condition: false
type: Species

metaM cmpacna c
type: Species
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
constant: false
is: HMDB01176
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57812

http://identifiers.org/biomodels.db/MODEL1310110041#_1b872878_3ac7_4fdb_9ab1_19e3698416fb
name: GBA
initial amount: NaN
is encoded by: hsa:2629
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaM 1pyr5c m
is: SBO:0000247
boundary condition: false
is: HMDB01301
initial amount: NaN
type: Species
constant: false
is: C03912
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
initial concentration: 1.0

metaM ksi pre14 g
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 14
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:28067

metaM m3mpdol U c
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:37632
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
initial amount: NaN
initial concentration: 1.0

metaM trdrd m
initial concentration: 1.0
constant: false
name: Reduced thioredoxin
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaM arachdcrn c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01322
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: CHEBI:57387

metaM ksii core4 pre10 g
is: CHEBI:28067
boundary condition: false
type: Species
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: keratan sulfate II biosynthesis, precursor 10

http://identifiers.org/biomodels.db/MODEL1310110041#_1c3b18d5_f97e_4325_bcda_5cf963376a7e
initial concentration: NaN
initial amount: NaN
name: ACO1
type: Species
is: P21399
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:48

http://identifiers.org/biomodels.db/MODEL1310110041#_c277f668_4bc1_445c_a526_ddccc3ff48c1
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9016
is: O95258
has only substance units: false
name: SLC25A14

metaR 5MTHFt2le
is described by: ECO:0000134
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is: SBO:0000185
name: 5-methyltetrahydrofolate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110041#
type: Reaction
fast: false

metaM ala D c
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
name: D-alanine
is: HMDB01310
initial concentration: 1.0
is: CHEBI:15570
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR RTOTALt
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
reactant: MODEL1310110041#
name: RTOTAL transport

metaR AG13T9g
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110041#
is: SBO:0000176
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110041#

metaM m4mpdol U c
is: CHEBI:37633
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN

metaR AHCYStr
reactant: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
fast: false
name: S-Adenosyl-L-homocysteine intracellular diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ

metaM retn r
boundary condition: false
is: HMDB01852
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
constant: false
is: CHEBI:35291
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_0867d2f8_8647_4caf_be2c_dc22c6e43bfc
constant: false
has only substance units: false
name: FUCA1
boundary condition: true
type: Species
is encoded by: hsa:2517
initial amount: NaN
initial concentration: NaN
is: P04066
is: SBO:0000252

metaM f1a l
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
is: CHEBI:17151
is: HMDB02917
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: F1alpha
constant: false

metaR 5AOPtm
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
name: 5-Aminolevulinate mitochondrial transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_acc44e35_b2de_42e3_8393_06e136eb157b
is: P05091
initial concentration: NaN
has only substance units: false
name: ALDH2
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:217

http://identifiers.org/biomodels.db/MODEL1310110041#_68af0f44_79d6_4f3f_b222_a0c03f5306e0
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:D87002
initial concentration: NaN
name: _D87002_1_m
type: Species
constant: false

metaR THRD L
kinetic law: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.3.1.17
modifier: MODEL1310110041#
name: L-threonine deaminase
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is: SBO:0000176
reactant: MODEL1310110041#
reversible: false
fast: false
type: Reaction

metaR PCHOLPr hs
name: choline phosphatase
product: MODEL1310110041#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_2729b367_65ce_4dac_b188_806379574718
name: CA5B
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:11238
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q9Y2D0

metaM btn m
is: HMDB00030
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57586
type: Species
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial concentration: 1.0
name: biotinate
is: SBO:0000247

metaM ha deg1 l
has only substance units: false
type: Species
is: CHEBI:16336
notes: FORMULA: C22H33N2O16 CHARGE: -1
name: hyaluronan degradation product 1
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4f5bc5ea_26c2_4ffd_9f85_4d96dd7b075e
initial amount: NaN
boundary condition: true
has only substance units: false
name: _PRO1933_1_m
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:PRO1933
constant: false

metaR TKT2
product: MODEL1310110041#
modifier: MODEL1310110041#
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_325cdb04_be0a_4aa4_9066_0693d33e6334
boundary condition: true
is: SBO:0000252
constant: false
is: Q14117
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1807
initial concentration: NaN
name: DPYS

metaM HC02175 c
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
is: CHEBI:27689
constant: false
boundary condition: false
name: caprate
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_056d4348_271f_4384_9cd1_53a3dca106fe
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q5SPY7
has only substance units: false
name: ENTPD2
type: Species
constant: false
is encoded by: hsa:954
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_b39ab8be_eaab_42e8_8986_099ac77f0f39
has only substance units: false
boundary condition: true
is encoded by: hsa:56301
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC7A10
type: Species
is: Q9NS82
is: SBO:0000252

metaR RE1521M
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
name: RE1521
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM dgmp e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP(2-)
boundary condition: false
constant: false
is: CHEBI:57673
is: HMDB01044
has only substance units: false
type: Species

metaR UDPGLCter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_ebf63729_d81a_4f37_9e2b_953eda4cd88e
initial amount: NaN
name: SLC23A2
constant: false
is encoded by: hsa:9962
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9UGH3
type: Species

metaM fol c
initial amount: NaN
name: Folate
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: HMDB00121
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_7952759a_4714_46b6_a24b_d12fc46007b3
name: ALDH1B1
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P30837
is encoded by: hsa:219

http://identifiers.org/biomodels.db/MODEL1310110041#_6542a0be_fbac_4dc9_96e3_da5986979dc7
initial concentration: NaN
constant: false
is encoded by: hsa:3032
has part: E9KL44
boundary condition: true
name: HADHA:HADHB
has only substance units: false
type: Species
is encoded by: hsa:3030
is: SBO:0000297
has part: P55084
initial amount: NaN

metaM ksi pre11 g
is: SBO:0000247
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 11
is: CHEBI:28067

metaR NDPK1m
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110041#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110041#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110041#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM ksi pre32 g
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
constant: false
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 32
boundary condition: false

metaM glyald c
is: C00577
is: HMDB01051
type: Species
constant: false
name: D-Glyceraldehyde
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17378

metaM ksi pre8 g
is: SBO:0000247
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28067
boundary condition: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 8
constant: false

metaM ala D e
has only substance units: false
type: Species
is: HMDB01310
name: D-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: CHEBI:15570
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaM btn n
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57586
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00030

metaR TKT1
reversible: true
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
name: transketolase
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.2.1.1
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction

metaR r2437
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reversible: false
product: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
fast: false
type: Reaction
reactant: MODEL1310110041#

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaR DOLPMT4 Uer
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#

metaR r0835
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false

metaM 34dhoxpeg e
is: http://identifiers.org/pubchem.compound/7902
notes: FORMULA: C8H10O4 CHARGE: 0 INCHI: InChI=1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2 EHMN_ABBREVIATION: C05576
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00318
boundary condition: false
has only substance units: false
name: 3,4-Dihydroxyphenylethyleneglycol
is: C05576

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_5ab835bc_50fb_4587_a5c0_8c0e7277eb0e
is encoded by: hsa:7357
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: UGCG
initial amount: NaN
constant: false
initial concentration: NaN
is: Q16739

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM galacglcgalgbside hs c
name: Gal-GlcNAc-Gal globoside
type: Species
initial concentration: 1.0
is: HMDB00061
is: SBO:0000247
constant: false
is: CHEBI:58343
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
has only substance units: false

metaM cmpacna g
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
is: CHEBI:57812
type: Species
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01176
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_5e0c69bf_5aaa_4073_b21f_f5186606c5be
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: CHST5
initial amount: NaN
constant: false
is encoded by: hsa:23563
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8209fecd_216f_47e2_bd6a_be6da9b01c34
has only substance units: false
type: Species
constant: false
name: UGP2
is encoded by: hsa:7360
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR PSSA1 hs
name: Phosphatidylserine synthase homo sapiens
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.29
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_d0e8b9fd_2c53_4d94_bbc5_2a9c25797b70
is: SBO:0000252
initial concentration: NaN
is: A8K3T7
is encoded by: hsa:27159
initial amount: NaN
has only substance units: false
name: CHIA
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8d7185dd_5469_44de_ad43_c4b6e5686d77
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5092
name: PCBD1
type: Species
initial amount: NaN
is: SBO:0000252
is: P61457
constant: false

metaM m7masnC g
boundary condition: false
initial concentration: 1.0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)
is: HMDB01313
notes: FORMULA: C64H107N2O50X CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:58469
constant: false
is: SBO:0000247

metaR 34DHOXPEGOX
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110041#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: true
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR r0836
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
reactant: MODEL1310110041#

metaM 5aizc c
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
initial amount: NaN
boundary condition: false
is: CHEBI:58564
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: HMDB06273
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2718a9bb_be4c_4348_9cf4_8a3be056d4a4
boundary condition: true
type: Species
is: P48065
name: SLC6A12
is: SBO:0000252
is encoded by: hsa:6539
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaM HC02175 e
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: caprate
initial concentration: 1.0
type: Species
is: CHEBI:27689

metaR M16NTg
modifier: MODEL1310110041#
is: SBO:0000176
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.143

metaM fol e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Folate
has only substance units: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
type: Species
constant: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM mi13p c
type: Species
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
has only substance units: false
name: 1D-myo-Inositol 1,3-bisphosphate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB06234
is: SBO:0000247
is: CHEBI:18225

metaM ksii core2 e
is: HMDB00211
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:17268
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_dce85ed8_baec_4852_b885_3e27a3530e06
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: _AA081045_1_e
is: SBO:0000252
is encoded by: hsa:AA081045

metaM gtp n
initial amount: NaN
has only substance units: false
name: GTP(4-)
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
constant: false
is: CHEBI:37565
is: HMDB01273
initial concentration: 1.0
type: Species

metaR ADEt
name: adenine reversible transport, cytosol
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_da98e220_f3f9_4b68_bbab_0450bd4f7e97
name: HLCS
initial amount: NaN
boundary condition: true
is: P50747
constant: false
is: SBO:0000252
is encoded by: hsa:3141
initial concentration: NaN
type: Species
has only substance units: false

metaR UMPK4n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110041#
is described by: ECO:0000269
reactant: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: UMP kinase (GTP),nuclear

metaM fe3 c
has only substance units: false
notes: FORMULA: Fe CHARGE: 3
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Fe3+
type: Species
initial amount: NaN
is: HMDB12943

metaR FTHFL
is described by: ECO:0000134
type: Reaction
name: Formate-tetrahydrofolate ligase
product: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR ASNtN1
modifier: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Asparagine transport (Na, H coupled)
fast: false
kinetic law: MODEL1310110041#
reversible: true

metaM orn e
name: Ornithine
type: Species
is: CHEBI:0
is: SBO:0000247
is: C01602
is: HMDB00214
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
boundary condition: false

metaM HC01231 m
is: CHEBI:58480
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM 10fthf6glu e
is: HMDB00108
is: CHEBI:16236
name: 10-formyltetrahydrofolate-[Glu](6)
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR r0549
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR r1993
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110041#

metaR r2132
kinetic law: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110041#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#

metaM fgam c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C04376
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
type: Species
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
has only substance units: false
constant: false
is: CHEBI:58426
is: HMDB01308
boundary condition: false

metaM arg L m
name: L-argininium(1+)
is: CHEBI:32682
initial concentration: 1.0
is: HMDB00517
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
type: Species
constant: false

metaM pi n
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00973
has only substance units: false
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
name: hydrogenphosphate

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction
is: SBO:0000185
reversible: false
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_9df51d08_102c_4bdf_ac07_74806f534043
type: Species
initial amount: NaN
is: SBO:0000252
name: GUCY1B2
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2974

metaM gtp m
name: GTP
type: Species
initial amount: NaN
is: CHEBI:37565
has only substance units: false
is: C00044
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273

metaR PGDI
is version of: http://identifiers.org/ec-code/5.3.99.2
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: Prostaglandin-H2 D-isomerase [Precursor]
modifier: MODEL1310110041#
reversible: true
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is described by: ECO:0000269
fast: false

metaR CBASPte
name: Transport of N-carbamoyl-L-aspartate
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110041#
type: Reaction
fast: false
reversible: true

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM lnlncg e
type: Species
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
boundary condition: false
is: CHEBI:32391
initial amount: NaN
name: gamma-linolenate
constant: false
initial concentration: 1.0
is: HMDB03073
is: SBO:0000247

metaM 11 cis retfa e
is: HMDB00108
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16236
name: fatty acid 11-cis-retinol
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_3692ccaf_7aba_4c0f_b3b5_35628a154511
has only substance units: false
initial concentration: NaN
constant: false
is: O15382
initial amount: NaN
boundary condition: true
type: Species
name: BCAT2
is: SBO:0000252
is encoded by: hsa:587

http://identifiers.org/biomodels.db/MODEL1310110041#_5bfd1160_d1a4_4dda_821a_75871bf7629a
boundary condition: true
has only substance units: false
is: Q9UM01
is encoded by: hsa:9056
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC7A7
is: SBO:0000252
type: Species

metaR RE2814M
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
fast: false
name: RE2814
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR r2133
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM HC01115 c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:29025
boundary condition: false
constant: false
name: NeuNGc
type: Species
initial amount: NaN
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

metaM arachdcrn m
is: HMDB01322
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57387

metaM galacglcgalgbside hs e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
initial amount: NaN
type: Species
is: C00124
is: CHEBI:0
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00143
name: Gal-GlcNAc-Gal globoside

metaR GALSGLT1le
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR r0830
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false

metaM thm c
is: HMDB00235
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
name: Thiamin
is: CHEBI:0
is: C00378
notes: FORMULA: C12H17N4OS CHARGE: 1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_81be8bde_05af_4dd1_a26c_d7959c39bafb
has part: Q9UN42
is encoded by: hsa:477
initial amount: NaN
is encoded by: hsa:23439
is: SBO:0000297
type: Species
boundary condition: true
name: ATP1B4:ATP1A2
constant: false
initial concentration: NaN
has part: P50993
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_12bdac24_5ac7_4f6a_bc34_e799ae5048a7
is encoded by: hsa:2530
has only substance units: false
name: FUT8
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: G3V5N0

metaM fe3 e
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:29034
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB12943
name: Fe3+
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_76469ef5_4abf_48ca_90bb_6a935f75169c
is encoded by: hsa:5140
type: Species
is: Q13370
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PDE3B
constant: false
initial amount: NaN
initial concentration: NaN

metaR AHCYStd
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
product: MODEL1310110041#
name: diffusion of S-Adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:

metaM pi m
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:43474
initial amount: NaN
is: HMDB00973
is: SBO:0000247
name: hydrogenphosphate
constant: false
has only substance units: false
is: C00009

http://identifiers.org/biomodels.db/MODEL1310110041#_24e30757_3cb9_48cd_b2bd_3649518dbf26
has only substance units: false
type: Species
is encoded by: hsa:1329
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: COX5B
is: SBO:0000252
constant: false
is: Q53YB7

metaM pac c
is: SBO:0000247
name: phenylacetate
type: Species
initial concentration: 1.0
is: CHEBI:18401
boundary condition: false
initial amount: NaN
is: HMDB00209
constant: false
has only substance units: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR RETI1
fast: false
type: Reaction
name: retinol isomerase (11-cis)
is: SBO:0000176
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110041#

metaR H2Ot
modifier: MODEL1310110041#
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
type: Reaction
is: SBO:0000185
name: H2O transport via diffusion
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_177d762d_9f73_4d31_bcf5_bb883cc26c4c
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80864
is: Q99944
is: SBO:0000252
name: EGFL8

metaR A4GALTg
is version of: http://identifiers.org/ec-code/2.4.1.228
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is described by: ECO:0000269
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Lactosylceramide 4-alpha-galactosyltransferase
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
type: Reaction

metaM dnad c
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
has only substance units: false
is: CHEBI:18304
initial concentration: 1.0
type: Species
name: Deamino-NAD+
constant: false
is: C00857
boundary condition: false
is: HMDB01179
initial amount: NaN

metaR 5ADTSTSTERONESte
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: sulfonated testosterone transport
is: SBO:0000185

metaM orn c
name: Ornithine
type: Species
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
is: SBO:0000247
is: C01602
is: HMDB00214
boundary condition: false
constant: false
initial amount: NaN

metaR S6T9g
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110041#

metaM dgdp m
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:58595
is: SBO:0000247
initial concentration: 1.0
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
name: dGDP(2-)
has only substance units: false

metaR LNLNCGt
fast: false
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000

metaR r2130
reactant: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#

metaR PPPGOm
name: protoporphyrinogen oxidase, mitochondrial
reversible: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.4
type: Reaction

metaR ORNtiDF
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
fast: false
name: ornithine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
modifier: MODEL1310110041#

metaM pi l
has only substance units: false
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
constant: false
name: hydrogenphosphate
initial amount: NaN
is: HMDB00973
type: Species
is: CHEBI:43474
boundary condition: false

metaM HC00591 c
name: 2-oxoglutaramate
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_bc323c44_83a9_42db_8b9d_e79300af82eb
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: Q9Y2A9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10331
type: Species
name: B3GNT3

metaR RE1523M
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1523
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c0d783f2_b2fd_42ed_950f_64ce9691f3c6
boundary condition: true
has only substance units: false
has part: P00326
initial concentration: NaN
type: Species
is encoded by: hsa:126
name: ADH1A:ADH1C
constant: false
is: SBO:0000297
initial amount: NaN

metaR ACP1 FMN
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110041#
is described by: ECO:0000254
type: Reaction
name: acid phosphatase (FMN)
reversible: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
fast: false
is: SBO:0000176

metaR AHCYSte
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110041#
fast: false
name: Transport of S-adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110041#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_2f5e65b0_253c_4f45_8933_024bfa66d769
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:7350
initial concentration: NaN
name: UCP1
has only substance units: false
initial amount: NaN
is: P25874

metaR FOLt2le
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110041#
name: folate transport via anion exchange
fast: false
reactant: MODEL1310110041#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_445fd170_8426_4f9c_8f9d_c052493beb46
initial amount: NaN
has only substance units: false
is encoded by: hsa:M68895
type: Species
initial concentration: NaN
is: SBO:0000252
name: _M68895_1_c
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_bb65aae6_aa49_4fd7_a5ba_7ebe4b2465c3
initial concentration: NaN
is: Q86SF2
is encoded by: hsa:51809
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: GALNT7
has only substance units: false
is: SBO:0000252

metaM HC01377 m
initial amount: NaN
boundary condition: false
is: CHEBI:27462
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
type: Species
name: S-(3-Methylbutanoyl)-dihydrolipoamide

metaM dttp n
is: C00459
constant: false
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
name: dTTP
initial concentration: 1.0
is: CHEBI:37568
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01342

metaM lnlncg c
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
boundary condition: false
name: gamma-linolenate
initial concentration: 1.0
is: CHEBI:32391
initial amount: NaN
is: HMDB03073
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_132b3804_6318_4e69_8387_d74cfd3dd998
name: SLC2A9
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56606
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_bdca6ba5_2cc6_4a38_9642_5cc01af7ad5d
is: SBO:0000297
name: ATP1A3:ATP1B2
constant: false
is encoded by: hsa:482
initial amount: NaN
initial concentration: NaN
has part: P14415
has only substance units: false
boundary condition: true
type: Species

metaR RE3565C
name: RE3565
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reversible: true
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction

metaM dttp m
type: Species
name: dTTP
initial amount: NaN
constant: false
is: CHEBI:37568
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00459
is: HMDB01342
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ffbe0aa9_8f71_4ef1_b0b4_75091e5cc01b
is encoded by: hsa:51179
initial concentration: NaN
name: HAO2
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false

metaR TYRTA
type: Reaction
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_20c0cf67_0c62_42d9_adf2_cc20b2f018f9
is: B7Z6S9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2629
has only substance units: false
type: Species
name: GBA
is: SBO:0000252
boundary condition: true
constant: false

metaR r1913
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false

metaM dgdp n
is: SBO:0000247
boundary condition: false
constant: false
name: dGDP(2-)
has only substance units: false
is: CHEBI:58595
initial concentration: 1.0
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
initial amount: NaN

metaM dgmp c
constant: false
is: SBO:0000247
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
name: dGMP
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01044
initial amount: NaN
is: CHEBI:57673

metaR G14T7g
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110041#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110041#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f0d667ef_c531_499c_81e4_bae0173708c2
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P37268
is encoded by: hsa:2222
boundary condition: true
constant: false
name: FDFT1
type: Species

metaM HC01401 m
type: Species
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial amount: NaN
is: CHEBI:27668
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

metaR B3GALT3g
type: Reaction
reversible: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.79
product: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269

metaR NS26Tg
reversible: false
fast: false
is described by: ECO:0000000
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
modifier: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.3
kinetic law: MODEL1310110041#

metaM dad 2 c
type: Species
is: CHEBI:17256
name: 2-deoxyadenosine
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: HMDB00101
initial amount: NaN
constant: false

metaM galacglcgalgbside hs g
is: CHEBI:26174
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
name: Gal-GlcNAc-Gal globoside
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR r2131
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110041#_c521dfca_9daf_4aab_8d27_ffda0c70a97c
has only substance units: false
is: Q9Y666
initial concentration: NaN
type: Species
boundary condition: true
name: SLC12A7
is: SBO:0000252
is encoded by: hsa:10723
constant: false
initial amount: NaN

metaM HC01842 c
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:31997
is: SBO:0000247
has only substance units: false
name: Phosphodimethylethanolamine
type: Species

metaR NACHEXA9ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110041#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176

metaM btn c
is: HMDB00030
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00120
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
type: Species
is: CHEBI:3420
initial amount: NaN
name: Biotin

metaM glyald m
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: CHEBI:17378
name: D-glyceraldehyde
has only substance units: false
is: HMDB01051
boundary condition: false
initial concentration: 1.0

metaR RE2814R
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_1a6c1572_b579_4d22_8dc6_9c40443bb83b
name: SLC28A1
boundary condition: true
is encoded by: hsa:9154
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: O00337
has only substance units: false

metaR r0483
reversible: true
product: MODEL1310110041#
type: Reaction
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110041#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

metaM so4 m
initial amount: NaN
constant: false
is: CHEBI:16189
has only substance units: false
is: SBO:0000247
is: HMDB01448
name: sulfate
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110041#_c14883b8_41ae_4d52_a3bb_c2f28091c437
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6576
name: SLC25A1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: D9HTE9

http://identifiers.org/biomodels.db/MODEL1310110041#_fbfce341_b4c8_4b0d_b63a_0a63a043e704
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:55568
constant: false
name: GALNT10
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r2136
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_1b4c7564_9491_45ae_b6a0_8ade164038cd
initial concentration: NaN
name: SLC24A1
is encoded by: hsa:9187
has only substance units: false
is: B4DUG1
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaM HC01399 m
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:27466
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110041#_180d6c9d_8cec_42de_885f_38040cd39a69
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: B3GALNT1
is: O75752
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8706
boundary condition: true

metaM 4pyrdx c
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
name: 4-pyridoxate
is: CHEBI:30959
is: HMDB00017
initial concentration: 1.0
boundary condition: false
constant: false

metaR r1860
kinetic law: MODEL1310110041#
name: Y+LAT2 Utilized transport
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_72fba006_a259_401c_a461_d233dd47ada0
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10873
boundary condition: true
name: ME3
is: SBO:0000252
is: Q6TCH8
has only substance units: false
type: Species
constant: false

metaM HC02149 c
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: CHEBI:28867
boundary condition: false
has only substance units: false
name: O-Propanoylcarnitine
is: SBO:0000247
constant: false

metaR r1914
product: MODEL1310110041#
fast: false
is: SBO:0000185
modifier: MODEL1310110041#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110041#
reversible: false

metaR OBDHc
is: SBO:0000176
kinetic law: MODEL1310110041#
name: 2-Oxobutanoate dehydrogenase, cytosolic
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#

metaR ALCD2yf
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
reactant: MODEL1310110041#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: false

metaM arachcrn m
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: HMDB06460
name: arachidyl carnitine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ca67abcc_bbbe_40f3_aecc_f9a473913d95
is: SBO:0000252
constant: false
initial concentration: NaN
name: TPI1
is encoded by: hsa:7167
initial amount: NaN
has only substance units: false
is: Q53HE2
type: Species
boundary condition: true

metaR DHORTS
fast: false
reactant: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
product: MODEL1310110041#
reversible: true
is described by: ECO:0000269
name: dihydroorotase
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:7916
name: (R)-Pantothenate
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_f42a4dfe_6fba_486f_9f6c_41bbbd3b600e
is: Q02318
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:1593
constant: false
name: CYP27A1

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110041#
name: retinol isomerase (9-cis)
kinetic law: MODEL1310110041#
product: MODEL1310110041#

metaR THFtm
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000185
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaR r2137
is described by: ECO:0000000
product: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_8360569b_4e39_4526_a89a_2b7ad2617ad6
initial concentration: NaN
type: Species
is encoded by: hsa:4144
name: MAT2A
is: P31153
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM HC01501 c
has only substance units: false
initial amount: NaN
name: hydroxidodioxidosulfidosulfate(1-)
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
initial concentration: 1.0
type: Species
is: CHEBI:33539

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galacglcgal14acglcgalgluside_hs_g
has only substance units: false
is: CHEBI:26174
constant: false
type: Species
boundary condition: false
name: i-antigen
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial concentration: 1.0

metaM pi r
is: HMDB00973
initial amount: NaN
type: Species
is: CHEBI:43474
boundary condition: false
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
constant: false
is: SBO:0000247
name: hydrogenphosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_b37677e5_1cd2_4788_827a_594d77eef0ee
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9UIG8
name: SLCO3A1
constant: false
type: Species
is encoded by: hsa:28232

metaR EX 34hpp
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR DRBK
reversible: false
name: Deoxyribokinase
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.15
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_8cf3c678_165e_443c_97e2_49e4771cdaac
type: Species
is: Q8TF71
name: SLC16A10
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:117247
initial concentration: NaN

metaM btn e
name: Biotin
is: HMDB00030
constant: false
is: SBO:0000247
is: C00120
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_9b4a8c1e_afb0_440c_b340_132e659bed91
is encoded by: hsa:80270
name: HSD3B7
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9H2F3
constant: false

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
name: acetylcholine
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15355
constant: false
is: HMDB00895

metaR TAUPAT1c
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of taurine into the intestinal cells by PAT1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_c97879c0_a273_49a3_b337_cae856ad51f5
name: SLC26A2
has only substance units: false
initial amount: NaN
is: P50443
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1836
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_d611a5ab_5c70_49b2_9c3c_95884a1970a5
is encoded by: hsa:347734
constant: false
name: SLC35B2
initial amount: NaN
is: Q8TB61
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaM CE2424 m
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
initial amount: NaN
boundary condition: false
is: CHEBI:28387
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
is: HMDB11123

metaM tdchola x
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951
initial concentration: 1.0
name: taurochenodeoxycholate
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:9407
is: SBO:0000247

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM core4 g
boundary condition: false
is: SBO:0000247
is: CHEBI:16478
initial concentration: 1.0
initial amount: NaN
name: Core 4
constant: false
has only substance units: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_e8191ded_3c84_4380_8f41_7c5df8ecf1bc
name: _AI924226_1_m
is: SBO:0000252
is encoded by: hsa:AI924226
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM pnto R c
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00210
boundary condition: false
type: Species
name: (R)-Pantothenate
is: CHEBI:7916
initial concentration: 1.0
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN

metaR RE3273C
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
modifier: MODEL1310110041#
name: RE3273

http://identifiers.org/biomodels.db/MODEL1310110041#_af5130eb_02ab_4c4c_849e_19235ac50303
type: Species
is: SBO:0000252
is encoded by: hsa:5052
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: PRDX1
has only substance units: false

metaM so4 l
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
is: HMDB01448
name: sulfate
type: Species
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110041#_31c994ed_e93d_4629_b25e_04f2fc665171
is encoded by: hsa:6519
constant: false
initial amount: NaN
has part: Q9UM01
type: Species
has part: Q07837
has only substance units: false
is encoded by: hsa:9056
name: SLC3A1:SLC7A7
boundary condition: true
is: SBO:0000297
initial concentration: NaN

metaM 5aop c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB01149
boundary condition: false
is: C00430
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
name: 5-Amino-4-oxopentanoate
is: CHEBI:17549
is: SBO:0000247
has only substance units: false

metaM uri c
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
initial concentration: 1.0
is: CHEBI:16704
is: SBO:0000247
initial amount: NaN
is: C00299
name: Uridine
type: Species
boundary condition: false
constant: false

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR 41R2A1H12BOOX
name: 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
kinetic law: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
reversible: false

metaR r1917
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR FAOXC4C2m
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C4-->C2)m
type: Reaction

metaM l2n2m2mn l
is: HMDB00143
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: CHEBI:12936
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_ec817793_3132_4a07_b3a0_04f98ef43f56
initial concentration: NaN
is encoded by: hsa:54363
type: Species
has only substance units: false
is: SBO:0000252
name: HAO1
initial amount: NaN
constant: false
is: Q9UJM8
boundary condition: true

metaR FACOAL180i
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
name: C180 fatty acid activation
modifier: MODEL1310110041#
fast: false
is: SBO:0000176
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases

metaR CHOLt4
product: MODEL1310110041#
fast: false
reversible: true
modifier: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
name: choline, sodium cotransport
is described by: ECO:0000269
is: SBO:0000185

metaR MM6bg
product: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
type: Reaction
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110041#

metaM HC00591 m
has only substance units: false
name: 2-oxoglutaramate
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16769
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_eaa98323_c382_4591_bf4f_368a152b959a
initial amount: NaN
is encoded by: hsa:R39999
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _R39999_1_c
type: Species
constant: false
boundary condition: true

metaM dttp c
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: C00459
is: SBO:0000247
name: dTTP
is: CHEBI:37568

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110041#

metaM btamp m
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial amount: NaN
initial concentration: 1.0
is: CHEBI:3110
is: HMDB04220
boundary condition: false
is: SBO:0000247
name: Biotinyl-5'-AMP

metaM val L e
constant: false
initial concentration: 1.0
is: CHEBI:16414
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
name: L-valine
boundary condition: false
is: HMDB00883
is: SBO:0000247
has only substance units: false

metaR r2129
product: MODEL1310110041#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM HC02207 c
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: CHEBI:27555
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM fad m
name: Flavin adenine dinucleotide oxidized
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16238
constant: false
is: SBO:0000247
is: C00016
is: HMDB01248

metaM f6p c
name: D-Fructose 6-phosphate
is: C00085
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
boundary condition: false
has only substance units: false
is: CHEBI:57579
initial amount: NaN
initial concentration: 1.0
constant: false

metaM cys L e
initial amount: NaN
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
has only substance units: false
type: Species
name: L-cysteine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17561

http://identifiers.org/biomodels.db/MODEL1310110041#_a60e18ae_a89c_41e9_9502_f6d295987eff
is: SBO:0000252
is encoded by: hsa:AI480132
constant: false
has only substance units: false
initial amount: NaN
name: _AI480132_1_c
initial concentration: NaN
boundary condition: true
type: Species

metaM h2o n
boundary condition: false
constant: false
is: HMDB02111
is: SBO:0000247
type: Species
name: water
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN

metaM arg L e
constant: false
type: Species
name: L-argininium(1+)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
is: CHEBI:32682
is: HMDB00517
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_91e5f96d_fca2_43a9_bbe2_ad4bbe36a324
initial amount: NaN
name: SLC7A8:SLC3A2
has only substance units: false
has part: Q86U05
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:23428
boundary condition: true
constant: false
type: Species

metaR r0541
modifier: MODEL1310110041#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110041#
type: Reaction

metaR r0611
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:

metaR THMPPtm
name: Thiamine diphosphate transport in via anion antiport, mitochondria
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_4b48e10c_6890_4768_9536_3bec89ef24c4
has only substance units: false
is encoded by: hsa:641371
is: SBO:0000252
name: ACOT1
initial concentration: NaN
initial amount: NaN
type: Species
is: E9KL42
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e27dd46c_443e_4125_b334_22af4bf0fff6
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ENTPD1
has only substance units: false
is encoded by: hsa:953
initial amount: NaN
constant: false
is: Q86VV3

http://identifiers.org/biomodels.db/MODEL1310110041#_870270a2_4620_41bc_b0f7_84ca846b44e2
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2530
has only substance units: false
boundary condition: true
initial concentration: NaN
name: FUT8
is: B4DFS7

metaR r2128
modifier: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110041#
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_990f617b_bdde_400b_9580_a20dae9e9d84
initial concentration: NaN
is: P11169
boundary condition: true
name: SLC2A3
type: Species
is: SBO:0000252
is encoded by: hsa:6515
initial amount: NaN
has only substance units: false
constant: false

metaM gln L c
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
name: L-glutamine
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00641
initial amount: NaN
is: CHEBI:18050
is: SBO:0000247

metaM retinal c
initial concentration: 1.0
is: CHEBI:15035
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358
boundary condition: false
type: Species

metaM lthstrl r
boundary condition: false
initial amount: NaN
is: HMDB01170
is: CHEBI:17168
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 5alpha-cholest-7-en-3beta-ol
type: Species

metaM h2o m
initial amount: NaN
is: C00001
initial concentration: 1.0
name: H2O
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
has only substance units: false
is: HMDB02111

metaM ile L e
constant: false
boundary condition: false
is: HMDB00172
has only substance units: false
is: CHEBI:17191
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
initial amount: NaN

metaR ADK3m
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
name: adentylate kinase (GTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reactant: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_b0a16ffc_8635_4f7c_85e1_8dfc706e9b7d
constant: false
is: A8K8P8
is: SBO:0000252
name: FUT8
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2530
type: Species
boundary condition: true

metaR PUNP2
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is: SBO:0000176
product: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: purine-nucleoside phosphorylase (Deoxyadenosine)

http://identifiers.org/biomodels.db/MODEL1310110041#_b26c49fe_e108_4aea_8bc6_fc263788e6a7
initial concentration: NaN
type: Species
is encoded by: hsa:AI971036
is: SBO:0000252
has only substance units: false
name: _AI971036_1_m
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_daee9bff_97d3_452c_9ab0_b342c61be62d
is: A8MU28
initial concentration: NaN
is encoded by: hsa:8883
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NAE1
constant: false
type: Species

metaR r0614
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
reversible: true
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_4135dbc5_6a92_4e19_9c50_a9dd057e68f2
is: P31937
type: Species
initial amount: NaN
initial concentration: NaN
name: HIBADH
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:11112
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_2a058043_09b8_4ca6_adbd_13707cdc8cbc
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA177072
type: Species
has only substance units: false
name: _AA177072_1_c
constant: false
initial concentration: NaN

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM dttp e
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
has only substance units: false
is: CHEBI:37568
is: HMDB01342
name: dTTP(4-)

metaR BDHm
product: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
fast: false
reactant: MODEL1310110041#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.30

metaR r2127
product: MODEL1310110041#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
type: Reaction

metaM HC00361 c
constant: false
boundary condition: false
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58335

metaM gmp g
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115
name: GMP(3-)
initial concentration: 1.0
has only substance units: false
is: HMDB01397
constant: false

metaM fuc L l
type: Species
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
is: HMDB00174
initial concentration: 1.0
is: CHEBI:18287
name: L-fucose
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM HC02208 c
name: prostaglandin-d1
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
initial concentration: 1.0
is: CHEBI:27696
constant: false
initial amount: NaN

metaM ksii core4 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
constant: false
initial amount: NaN
notes: FORMULA: C83H134N7O61SX CHARGE: -2
initial concentration: 1.0
is: HMDB00175
has only substance units: false
type: Species
is: C00130
boundary condition: false
is: CHEBI:58053
is: SBO:0000247

metaM HC02207 e
name: prostaglandin-c2
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM arachdcrn r
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: C20:4 carnitine
is: CHEBI:57368
is: SBO:0000247
is: HMDB06523

metaR PUNP1
fast: false
kinetic law: MODEL1310110041#
name: purine-nucleoside phosphorylase (Adenosine)
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR GALt2 2
is: SBO:0000185
reactant: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
fast: false
type: Reaction
modifier: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
name: D-galactose transport via proton symport
kinetic law: MODEL1310110041#

metaR r0145
is version of: http://identifiers.org/ec-code/1.8.3.1
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a7e2bad0_1ca4_47ef_b5d2_8236bbcfb2c0
is: P30084
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ECHS1
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1892

metaR HISTAtu
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000269
name: Histamine uniport
reactant: MODEL1310110041#
reversible: true

metaM HC01415 m
constant: false
is: CHEBI:27537
initial concentration: 1.0
initial amount: NaN
name: (2E)-Octenoyl-CoA
boundary condition: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_bcb134f2_df30_4407_95cc_68e953c42521
is encoded by: hsa:10195
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: ALG3
constant: false
boundary condition: true

metaR S6TASE22ly
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_8476c330_51f8_4fe7_a7fc_9f275aad7d47
is encoded by: hsa:6241
constant: false
name: RRM2
is: P31350
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR r2126
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_2af46394_4a43_4f68_bb34_1fb694a31875
name: NDUFB3
constant: false
is: SBO:0000252
is encoded by: hsa:4709
boundary condition: true
has only substance units: false
is: Q6IB80
type: Species
initial concentration: NaN
initial amount: NaN

metaM ile L c
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00172
has only substance units: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
is: CHEBI:17191
name: L-isoleucine
is: SBO:0000247

metaR DTTPtm
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110041#
name: transport of dTTP into mitochondria
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
fast: false
reversible: false
reactant: MODEL1310110041#

metaR PE HStm
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
type: Reaction
reversible: true
name: phosphatidylethanolamine scramblase

metaR GASNASE3ly
fast: false
is described by: ECO:0000000
modifier: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
name: glycosylasparaginase, lysosomal
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM bhb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: SBO:0000247
boundary condition: false
is: HMDB00011
is: CHEBI:10983
initial amount: NaN

metaM hmgcoa m
is: HMDB01375
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: CHEBI:15467
constant: false
is: SBO:0000247
boundary condition: false

metaM but e
is: HMDB00039
type: Species
is: CHEBI:17968
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247
name: butyrate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaM h2o r
constant: false
initial concentration: 1.0
has only substance units: false
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: CHEBI:15377
name: H2O
is: HMDB02111
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR SPC HSt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
type: Reaction

metaR PUNP4
reversible: true
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110041#
fast: false
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110041#_280c4022_80b9_42e1_8560_50a8f21c75db
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: HADHA
initial amount: NaN
is: E9KL44
is encoded by: hsa:3030

metaM CE4792 m
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:12947
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_8e93ca95_57fc_4e01_9e31_0fab95c677b7
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _D87002_1_e
initial amount: NaN
is encoded by: hsa:D87002
is: SBO:0000252

metaR DOPAt4 2 r
type: Reaction
kinetic law: MODEL1310110041#
fast: false
is: SBO:0000185
reactant: MODEL1310110041#
name: Dopamine reversible transport in via sodium symport (1:2)
modifier: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
product: MODEL1310110041#

metaM HC02208 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
constant: false
is: CHEBI:27696
type: Species
boundary condition: false
name: prostaglandin-d1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR HPYRR2x
reversible: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
name: hydroxypyruvate reductase (NADH)
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.1.27
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000304

metaM trdox m
constant: false
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: CHEBI:18191
initial amount: NaN
name: Oxidized thioredoxin
initial concentration: 1.0

metaM nadh c
is: HMDB01487
is: C00004
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
boundary condition: false
constant: false
has only substance units: false

metaR PGMT
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
name: phosphoglucomutase
reactant: MODEL1310110041#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
reversible: true
product: MODEL1310110041#
is described by: ECO:0000134

metaM dgdp c
name: dGDP
is: HMDB00960
type: Species
is: C00361
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58595
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaR DURIPP
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
name: deoxyuridine phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.3
product: MODEL1310110041#

metaM drib e
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB03224
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:28816
name: 2-deoxy-D-ribose

metaM m4mpdol U r
type: Species
initial concentration: 1.0
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR DTTPtn
reversible: true
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#
reactant: MODEL1310110041#
name: dTTP diffusion in nucleus
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR r0545
fast: false
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR C14STRr
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
is described by: ECO:0000134
reversible: false
name: C-14 sterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110041#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
modifier: MODEL1310110041#

metaR P4504F123r
type: Reaction
is: SBO:0000176
name: cytochrome p450 4F12/4F2
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (66002.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES:omega hydroxylation of ebastine NJ
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false

metaM ksi l
is: C00445
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
constant: false
has only substance units: false
name: keratan sulfate I
boundary condition: false
type: Species
is: HMDB01354
is: CHEBI:57455
initial concentration: 1.0

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR PUNP3
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110041#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Guanosine)
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false

metaM so4 e
initial concentration: 1.0
is: HMDB01448
is: SBO:0000247
name: sulfate
constant: false
is: CHEBI:16189
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0344
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_c88f088b_0973_4b85_9419_907a5288a005
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:57835
name: SLC4A5
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
is: HMDB00039
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17968
initial concentration: 1.0
name: butyrate

http://identifiers.org/biomodels.db/MODEL1310110041#_3d8d849a_f1d9_4f25_b05c_d45ae859ff36
boundary condition: true
is: Q9BZX2
has only substance units: false
constant: false
initial amount: NaN
name: UCK2
initial concentration: NaN
is encoded by: hsa:7371
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_295e4e19_cafb_4860_a798_63ccbc4df803
type: Species
is: SBO:0000252
constant: false
name: MOGS
is: F5H6D0
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:7841
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_43dbe17e_04f6_4eb3_affc_7b74c47b0f5f
initial amount: NaN
constant: false
has only substance units: false
is: Q86YW0
type: Species
is encoded by: hsa:89869
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PLCZ1

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR r0610
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
type: Reaction
reversible: true
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
is described by: ECO:0000000

metaM bhb c
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

metaM ksi deg40 l
name: keratan sulfate I, degradation product 40
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110041#_441e7103_dd5b_4623_ac4a_9d8cb811fc92
constant: false
has only substance units: false
is: Q5QPH3
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ACSS2
initial amount: NaN
is encoded by: hsa:55902

http://identifiers.org/biomodels.db/MODEL1310110041#_5abf24b1_84db_44eb_b9c4_beb2a55c6170
has only substance units: false
name: CYP7B1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: O75881
is encoded by: hsa:9420
constant: false

metaR r1418
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction

metaM prostgi2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
name: prostaglandin I2(1-)
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57403
is: HMDB01335

metaR PUNP6
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
name: purine-nucleoside phosphorylase (Deoxyinosine)
modifier: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176

metaM gmp c
is: HMDB01397
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58115
initial amount: NaN
is: C00144
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP

http://identifiers.org/biomodels.db/MODEL1310110041#_5e55b393_d561_4121_ace7_b25003fc6ac8
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q6NVY1
is encoded by: hsa:26275
has only substance units: false
initial amount: NaN
constant: false
name: HIBCH
boundary condition: true

metaR S6TASE25ly
fast: false
reversible: true
reactant: MODEL1310110041#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR G14T17g
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
product: MODEL1310110041#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110041#

metaM arachdcrn x
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB06523
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: C20:4 carnitine
type: Species
initial concentration: 1.0
is: CHEBI:57368

metaR PAIL45P HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#

metaM succ x
has only substance units: false
is: CHEBI:30031
is: SBO:0000247
type: Species
name: Succinate
initial amount: NaN
initial concentration: 1.0
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_70103d0e_e273_46d0_9e98_0aa6413dec04
type: Species
is encoded by: hsa:114134
initial concentration: NaN
name: SLC2A13
constant: false
has only substance units: false
is: Q96QE2
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM drib c
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB03224
initial concentration: 1.0
boundary condition: false
constant: false
name: 2-deoxy-D-ribose
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
is: CHEBI:28816

metaR SIAT4Bg
product: MODEL1310110041#
reactant: MODEL1310110041#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110041#

metaR GLYt7 211 r
is: SBO:0000185
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
reversible: true
is described by: ECO:0000269
name: glycine reversible transport via sodium and chloride symport (2:1:1)

metaR CHOLD2m
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.1.99.1
reversible: false
type: Reaction
is: SBO:0000176
name: choline dehydrogenase (FAD acceptor), mitochondrial
kinetic law: MODEL1310110041#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_eda78cca_392c_4e8c_985d_a7ff79d01b3d
type: Species
is: P04746
name: AMY2A
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:279

metaR r0149
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.14.13.39
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM mi1345p c
is: HMDB01059
initial amount: NaN
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57895

metaM dhap x
constant: false
is: HMDB01473
is: C00111
initial amount: NaN
is: CHEBI:57642
has only substance units: false
type: Species
name: Dihydroxyacetone phosphate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
is: SBO:0000247

metaR S6T1g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110041#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110041#
type: Reaction

metaR DHFR
is: SBO:0000176
reactant: MODEL1310110041#
is described by: ECO:0000254
name: dihydrofolate reductase
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110041#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
product: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_2c66c134_ee0d_4714_817c_40455645c4a7
is encoded by: hsa:2194
has only substance units: false
name: FASN
boundary condition: true
initial amount: NaN
is: P49327
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_8b228072_f8fd_4bbc_a10e_a459fd66ce4e
name: PDE9A
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR RETNt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
product: MODEL1310110041#
reversible: true
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
name: retinoic acid transport
type: Reaction

metaM so4 c
initial concentration: 1.0
name: sulfate
is: HMDB01448
boundary condition: false
is: CHEBI:16189
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
type: Species

metaR LTD4DP
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
type: Reaction
fast: false
reversible: true
is: SBO:0000176
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000

metaM ksi deg6 l
constant: false
boundary condition: false
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 6
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
has only substance units: false
type: Species

metaR PPBNGS
is described by: ECO:0000269
product: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.24
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
name: porphobilinogen synthase
fast: false

metaR PRPPS
type: Reaction
fast: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true
name: phosphoribosylpyrophosphate synthetase
is version of: http://identifiers.org/ec-code/2.7.6.1
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR KHte
is: SBO:0000185
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
type: Reaction
name: KHte
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR FUMSO3tm
reversible: true
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#

metaR NACHEXA15ly
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110041#
fast: false

metaR CYTK12
type: Reaction
product: MODEL1310110041#
name: cytidylate kinase (dCMP,dCTP)
reversible: true
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110041#

metaM HC01434 m
initial amount: NaN
name: oxalatosuccinate(3-)
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
is: CHEBI:58931
constant: false

metaR r2338
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_7da6102c_722c_44f6_8663_1bdb22291711
is: Q9P212
has only substance units: false
name: PLCE1
boundary condition: true
is encoded by: hsa:51196
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR ARGtm
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: arginine mitochondrial transport via ornithine carrier
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_0daf0fa1_cb58_4aba_867d_a3d064b79979
name: CA7
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:766
has only substance units: false
is: P43166
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_a57d543f_e91b_46e2_ab13_556817b71190
is encoded by: hsa:1607
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: DGKB
initial amount: NaN
boundary condition: true
type: Species

metaM 7dhf l
name: heptaglutamyl folate (DHF)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB06559
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1

metaM fad e
is: CHEBI:16238
is: HMDB01248
constant: false
initial amount: NaN
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false
is: C00016
boundary condition: false

metaR r0407
modifier: MODEL1310110041#
reversible: true
fast: false
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_3b2d6ef1_e447_45b6_bbef_066f870c4f67
is: SBO:0000252
is encoded by: hsa:1608
constant: false
name: DGKG
type: Species
is: P49619
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM prostgi2 e
is: CHEBI:57403
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
initial amount: NaN
constant: false
name: prostaglandin I2(1-)
type: Species

metaM ak2lgchol hs c
has only substance units: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial concentration: 1.0
is: C04317
constant: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial amount: NaN
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
boundary condition: false

metaM ksi deg38 l
type: Species
boundary condition: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate I, degradation product 38
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaM xoltri27 e
type: Species
name: 7alpha,26-dihydroxycholesterol
is: SBO:0000247
boundary condition: false
is: CHEBI:18431
is: HMDB06281
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1

metaM pram c
has only substance units: false
is: SBO:0000247
is: HMDB01128
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN
is: CHEBI:58681
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: C03090

metaM tdcoa m
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C02593
is: CHEBI:57385
boundary condition: false
is: HMDB01521

metaM glyc e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00131
name: Glycerol
is: CHEBI:17754
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_87be7798_d7f6_4706_8261_4f482f58043f
initial concentration: NaN
is: Q11201
initial amount: NaN
type: Species
is encoded by: hsa:6482
constant: false
boundary condition: true
has only substance units: false
name: ST3GAL1
is: SBO:0000252

metaR PEAMNO
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
reversible: false
product: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e47fc4bd_9e3d_40c2_b022_3262c520de29
name: PLCD1
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P51178
is encoded by: hsa:5333
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_d67eeb6f_380b_4eaf_a9f4_c5eac9b0f05a
type: Species
has only substance units: false
name: SLC17A3
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: O00476
is encoded by: hsa:10786
boundary condition: true

metaM HC00718 c
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

metaR CYTK11
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_ce16cc67_204c_4a1c_88bc_bcec91322f92
name: HADH
is encoded by: hsa:3033
constant: false
initial concentration: NaN
type: Species
is: Q16836
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_c8cd7120_c1dd_4db2_9a60_4304d06c27f2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6487
constant: false
type: Species
name: ST3GAL3
has only substance units: false
initial amount: NaN

metaR GCCam
is: SBO:0000176
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000269
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
product: MODEL1310110041#
modifier: MODEL1310110041#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110041#_8d5657a4_b89e_4222_9530_2b13cf9b8ec1
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:26002
name: MOXD1
initial concentration: NaN
constant: false
has only substance units: false
is: Q6UVY6

http://identifiers.org/biomodels.db/MODEL1310110041#_bc56a9fe_19fb_4f34_a67b_a74b917bd24b
name: PPAP2A
is: G3XA95
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:8611
is: SBO:0000252

metaR NAGA2ly
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.49
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
is: SBO:0000176
type: Reaction
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reactant: MODEL1310110041#

metaR CYTK7n
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP),nuclear
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_f6decce6_095f_4a4d_9148_619be59b7d25
constant: false
is: P05187
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:250
initial amount: NaN
name: ALPP
type: Species

metaM retn e
name: all-trans-retinoate
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:35291
boundary condition: false
is: HMDB01852
has only substance units: false

metaM 7dhf m
name: heptaglutamyl folate (DHF)
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06559
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
initial amount: NaN

metaM thym e
type: Species
has only substance units: false
is: HMDB00262
name: thymine
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821

metaR GALGALGALTHCRMtg
type: Reaction
is described by: ECO:0000000
name: galgalgalthcrm hs intracellular transport
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaR r0973
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110041#
reversible: true
is: SBO:0000185
product: MODEL1310110041#

metaR PUNP7
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Xanthosine)
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269

metaM 34dhoxmand m
has only substance units: false
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
is: SBO:0000247
is: HMDB01866
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR MM8Cg
fast: false
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
is: SBO:0000176
modifier: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_f7a68005_0329_4ab5_a9c7_29ffcd3ffc51
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:100128062
has only substance units: false
initial concentration: NaN
type: Species
name: _100128062_1_m

metaR r0408
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
product: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110041#

metaM CE2435 m
is: SBO:0000247
name: trans,cis-deca-2,4-dienoyl-CoA
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
constant: false
has only substance units: false
initial amount: NaN
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_19286deb_e93b_454a_8da8_cf7ffb24bbb5
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110041#_38900421_c515_4f79_9904_3ff39aeea9da
is: P24311
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: COX7B
is encoded by: hsa:1349
type: Species
is: SBO:0000252
boundary condition: true
constant: false

metaM andrstandn r
type: Species
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
boundary condition: false
is: HMDB00899
is: SBO:0000247
name: 5alpha-androstane-3,17-dione
has only substance units: false
is: CHEBI:15994
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9ac18165_2b3e_4d12_a3e6_67ae32c30870
type: Species
initial amount: NaN
is: SBO:0000252
name: CA7
initial concentration: NaN
has only substance units: false
is: Q86YU0
constant: false
is encoded by: hsa:766
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_54bd6840_a872_4a59_86e2_2de9a5dad8e3
name: RPE
is: Q53TV9
is encoded by: hsa:6120
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR UGLCNACtg
modifier: MODEL1310110041#
is described by: ECO:0000269
reversible: true
name: UDP-GlcNAc Golgi transport via CMP antiport
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
is: SBO:0000185

metaM 5hoxindact c
type: Species
is: HMDB04073
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (5-hydroxyindol-3-yl)acetaldehyde
constant: false
is: CHEBI:50157
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
boundary condition: false

metaR CYTK10
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
type: Reaction
name: cytidylate kinase (CMP,dGTP)
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110041#

metaR GMAND
reversible: false
name: GDP-D-mannose dehydratase
modifier: MODEL1310110041#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
is version of: http://identifiers.org/ec-code/4.2.1.47
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR r1381
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110041#
is: SBO:0000176
type: Reaction
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5

metaM gua e
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
is: HMDB00132
name: guanine
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16235

metaM crn c
initial concentration: 1.0
constant: false
is: CHEBI:16347
is: SBO:0000247
is: C00318
has only substance units: false
initial amount: NaN
name: L-Carnitine
type: Species
is: HMDB00062
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110041#_c2d298cf_0317_4a69_afe1_c8a5495707ac
initial concentration: NaN
type: Species
is encoded by: hsa:HG2846-HT2983
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: _HG2846_HT2983_1_c
is: SBO:0000252

metaM 5HPET c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57450
type: Species
name: 5(S)-HPETE(1-)
boundary condition: false
is: HMDB01193
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1

metaM ak2lgchol hs e
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial concentration: 1.0
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6975
has only substance units: false
is: C04317

metaR r1527
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
reversible: false
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1

metaM h2o x
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
is: C00001
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15377
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02111
type: Species

metaR G13MT U
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.132
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110041#_0b3ea26f_035c_4a2c_b192_98c479e95879
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4758
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q99519
name: NEU1

metaM xoltri27 c
name: 7alpha,26-dihydroxycholesterol
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:18431
is: HMDB06281
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17?,18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1

metaM ksi g
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: keratan sulfate I
is: HMDB02092
is: CHEBI:17240

metaM 6a2ohxnt x
has only substance units: false
is: CHEBI:17534
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
constant: false
name: 6-amino-2-oxohexanoic acid
boundary condition: false
type: Species
initial amount: NaN
is: HMDB12151

metaM fad c
is: CHEBI:16238
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
boundary condition: false
type: Species
is: C00016
initial amount: NaN
constant: false
is: HMDB01248

metaR UMPK
is: SBO:0000176
reversible: true
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: UMP kinase
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM fuc L c
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: L-fucose
is: HMDB00174
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaM glyc c
initial concentration: 1.0
type: Species
name: Glycerol
is: SBO:0000247
is: CHEBI:17754
is: HMDB00131
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
constant: false
boundary condition: false
initial amount: NaN

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_8c47def7_5c8b_4cf2_a7b8_41e8f77a1050
is: SBO:0000252
initial concentration: NaN
is: O95340
constant: false
is encoded by: hsa:9060
type: Species
initial amount: NaN
name: PAPSS2
boundary condition: true
has only substance units: false

metaR r0360
type: Reaction
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.16
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176

metaR S6T11g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: false

metaM fuc L e
is: CHEBI:18287
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
name: L-fucose
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00174

metaM prostgd2 c
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
is: HMDB01403
initial amount: NaN
constant: false
name: prostaglandin D2(1-)
has only substance units: false
boundary condition: false

metaM C04849 e
has only substance units: false
initial concentration: 1.0
type: Species
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM retn c
is: HMDB01852
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
has only substance units: false
name: all-trans-retinoate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:35291

metaM acn13acngalgbside hs c
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:3338
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
boundary condition: false
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
is: C00036
is: SBO:0000247
is: HMDB00223

metaR GALASE12ly
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110041#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176

metaM thym c
name: Thymine
is: CHEBI:17821
type: Species
is: HMDB00262
initial concentration: 1.0
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00178

metaR UDPGALtg
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: true

metaR r1380
product: MODEL1310110041#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72

http://identifiers.org/biomodels.db/MODEL1310110041#_c55d6ea5_f56a_4c43_9880_9118c491d79b
initial amount: NaN
name: ACOT7
is encoded by: hsa:11332
constant: false
is: SBO:0000252
is: O00154
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_7aa98bc4_acbf_4bc6_908a_743eee454509
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: ACP5
is: P13686
is encoded by: hsa:54

metaM ribflv e
is: SBO:0000247
is: C00255
has only substance units: false
is: CHEBI:3554
initial concentration: 1.0
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
initial amount: NaN
name: Riboflavin
constant: false
type: Species

metaM itacon m
is: CHEBI:17240
name: itaconate(2-)
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
has only substance units: false
is: SBO:0000247
is: HMDB02092
boundary condition: false
constant: false

metaM 3hibutcoa m
type: Species
boundary condition: false
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
is: CHEBI:28259
name: (S)-3-Hydroxyisobutyryl-CoA
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_95d3b136_b5bd_491f_9b8b_08264b9cf13c
is encoded by: hsa:2530
has only substance units: false
is: Q546E0
initial amount: NaN
boundary condition: true
constant: false
name: FUT8
is: SBO:0000252
type: Species
initial concentration: NaN

metaR GDPFUCtg
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
name: GDPFuc Golgi transport via CMP antiport
is: SBO:0000185
modifier: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
reversible: true
product: MODEL1310110041#
is described by: ECO:0000269

metaM ttdca e
is: CHEBI:30807
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: C06424
initial amount: NaN
type: Species
constant: false
is: HMDB00806
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM m5mpdol U r
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:37634
is: SBO:0000247

metaR GALASE8ly
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110041#

metaM tdchola c
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00951
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
is: CHEBI:9407
type: Species

metaR AG13T8g
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110041#

metaM ocdca c
type: Species
is: CHEBI:25629
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00827
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
constant: false
name: stearate

metaM 1pyr5c c
boundary condition: false
is: CHEBI:15893
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial concentration: 1.0
is: HMDB01301
name: 1-Pyrroline-5-carboxylate
is: C03912

http://identifiers.org/biomodels.db/MODEL1310110041#_b120ee3c_b0a2_4114_9c9b_b35c77109b73
name: _AI091231_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI091231
boundary condition: true

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_8b3d225b_3cf8_46f9_81bf_651970d4ff3f
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:2588
initial concentration: NaN
is: P34059
is: SBO:0000252
name: GALNS
constant: false
has only substance units: false

metaR r2334
reversible: true
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR RE3520E
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000000
name: RE3520
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
kinetic law: MODEL1310110041#
reversible: true
modifier: MODEL1310110041#
is: SBO:0000176
type: Reaction

metaM 56dthm c
name: 5,6-dihydrothymine
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00079
is: SBO:0000247
is: CHEBI:27468
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
type: Species

metaR AG13T14g
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110041#
reversible: false

metaR r0403
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.4.4
kinetic law: MODEL1310110041#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110041#

metaR r0033
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
product: MODEL1310110041#
is described by: ECO:0000000

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
reactant: MODEL1310110041#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
fast: false
product: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#

metaM ksi e
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB00211
initial concentration: 1.0
is: CHEBI:17268
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: keratan sulfate I
initial amount: NaN

metaR r0616
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000

metaM 3ohdcoa m
has only substance units: false
initial amount: NaN
is: HMDB06402
type: Species
is: CHEBI:57349
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
constant: false
name: 3-oxopalmitoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110041#_905be44a_0064_4234_8268_cf915b6a9258
initial concentration: NaN
boundary condition: true
name: PDE9A
is encoded by: hsa:5152
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaM pi c
name: hydrogenphosphate
initial concentration: 1.0
constant: false
is: HMDB00973
is: CHEBI:43474
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00009
notes: FORMULA: HO4P CHARGE: -2
boundary condition: false
type: Species

metaR FAOXC80
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110041#
is described by: ECO:0000269
product: MODEL1310110041#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110041#
name: Beta oxidation of med/long chain fatty acid

metaM ksii core2 l
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB02092
is: SBO:0000247
boundary condition: false
is: CHEBI:17240
name: keratan sulfate II (core 2-linked)
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110041#_bc6ee80b_07e7_4f78_9989_b130956f4e29
is: SBO:0000252
is encoded by: hsa:218
has only substance units: false
initial concentration: NaN
is: P30838
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: ALDH3A1

metaM acn13acngalgbside hs e
constant: false
type: Species
is: CHEBI:3338
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
is: C00036
is: HMDB00223
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM lac L c
type: Species
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
has only substance units: false
is: HMDB00190
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16651
is: SBO:0000247
name: (S)-lactate

metaM Rtotal2 e
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247
is: C00255
has only substance units: false
name: R total 2 position
is: HMDB00244
is: CHEBI:3554

metaM prostgd2 e
name: prostaglandin D2(1-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
initial concentration: 1.0
is: CHEBI:57406
is: HMDB01403
initial amount: NaN
constant: false
type: Species

metaM octa e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false
is: HMDB00482
is: C06423
name: octanoate (n-C8:0)
initial concentration: 1.0
type: Species
is: CHEBI:25646
boundary condition: false

metaM leuktrF4 e
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06465
is: SBO:0000247
initial amount: NaN
constant: false
name: leukotriene F4
is: CHEBI:27491
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e8a4cde1_04f2_47be_bf04_e58d28d9b8fe
type: Species
is: O75251
initial amount: NaN
initial concentration: NaN
name: NDUFS7
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:374291

metaM tdchola e
is: SBO:0000247
initial amount: NaN
is: HMDB00951
boundary condition: false
is: CHEBI:9407
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
constant: false

metaR GCCbim
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false
product: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000269

metaR r0829
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaR GGH 6DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
reversible: false
reactant: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
name: Gamma-glutamyl hydrolase (6DHF), extracellular
modifier: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR CORE4GTg
fast: false
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
modifier: MODEL1310110041#
reversible: false
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
is described by: ECO:0000000
is: SBO:0000176

metaR MM5ag
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
is: SBO:0000176
fast: false

metaM gtp c
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
initial amount: NaN
type: Species
is: HMDB01273
has only substance units: false
is: C00044
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37565
is: SBO:0000247

metaM 5thf e
initial amount: NaN
is: HMDB06487
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H45N11O18 CHARGE: -6
name: pentaglutamyl folate (THF)
has only substance units: false
type: Species
constant: false

metaM ocdca e
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)
initial concentration: 1.0
boundary condition: false
is: C01530
is: SBO:0000247
is: HMDB00827
constant: false
is: CHEBI:25629

metaR SERLYSNaex
type: Reaction
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reactant: MODEL1310110041#
name: Serine/Lysine Na-dependent exchange (Ser in)
modifier: MODEL1310110041#
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_71b83e2d_519e_4aef_94b4_b5bad3b97044
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: PTS
type: Species
boundary condition: true
is: Q03393
is encoded by: hsa:5805

http://identifiers.org/biomodels.db/MODEL1310110041#_a84e2625_c3d6_4a0f_bd1f_a917db1e9da2
name: PPT1
constant: false
initial amount: NaN
is encoded by: hsa:5538
is: Q6FGQ4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR r2332
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true

metaM cys L c
type: Species
has only substance units: false
initial amount: NaN
name: L-cysteine
boundary condition: false
initial concentration: 1.0
is: HMDB00574
constant: false
is: SBO:0000247
is: CHEBI:17561
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099

metaM val L c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
has only substance units: false
constant: false
boundary condition: false
name: L-valine
is: CHEBI:16414
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM f1a g
type: Species
boundary condition: false
has only substance units: false
name: F1alpha
constant: false
is: CHEBI:17151
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_dfab2114_f652_41dd_bf54_4ef99cff1f90
is encoded by: hsa:57282
initial concentration: NaN
constant: false
name: SLC4A10
is: B7Z1R0
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_5578dd11_a70e_412c_a715_7ac9c1486e21
constant: false
is: SBO:0000252
name: HMGCS1
is encoded by: hsa:3157
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q01581
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_c1809a17_d4a2_4918_9ea6_c1871516a406
constant: false
is encoded by: hsa:56953
has only substance units: false
boundary condition: true
is: Q9NPB1
type: Species
name: NT5M
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r0365
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110041#
is described by: ECO:0000000
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
reversible: false

metaR r0618
product: MODEL1310110041#
is: SBO:0000176
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: true
is described by: ECO:0000000

metaR F1Atg
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110041#
name: F1alpha transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
fast: false

metaR EBASTINEte
type: Reaction
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: xenobiotic transport

metaM chol c
name: Choline
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:15354
boundary condition: false
is: SBO:0000247
is: HMDB00097
has only substance units: false
type: Species
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR r0974
kinetic law: MODEL1310110041#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
name: Active transport
type: Reaction
fast: false
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_300ef378_bbf0_4445_a92e_e016b9e9ae93
constant: false
type: Species
initial amount: NaN
is: B7Z2M9
name: DGKZ
initial concentration: NaN
is encoded by: hsa:8525
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM gln L e
name: L-glutamine
has only substance units: false
is: CHEBI:18050
is: HMDB00641
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
initial amount: NaN

metaR r1384
product: MODEL1310110041#
reversible: true
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

metaM leuktrF4 c
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: CHEBI:27491
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06465
name: leukotriene F4
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR MTRI
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 5.3.1.23 Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000176
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
name: 5-methylthioribose-1-phosphate isomerase
fast: false

metaR DOLPMT2 Uer
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110041#

metaR r2333
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaM octa c
initial amount: NaN
name: octanoate (n-C8:0)
boundary condition: false
has only substance units: false
type: Species
is: HMDB00482
is: CHEBI:25646
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false
is: C06423

metaM lac L e
name: (S)-lactate
constant: false
type: Species
is: HMDB00190
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110041#_abea72a3_1ba2_44d3_a5c6_c622f32bd087
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55163
constant: false
initial amount: NaN
name: PNPO
is: Q9NVS9
has only substance units: false
initial concentration: NaN

metaM Rtotal2 c
initial concentration: 1.0
is: CHEBI:60377
constant: false
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
name: R total 2 position
initial amount: NaN
is: HMDB00095
is: SBO:0000247
is: C00055
boundary condition: false

metaM adn m
boundary condition: false
is: CHEBI:16335
is: HMDB00050
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: adenosine
type: Species

metaR APOCF
reactant: MODEL1310110041#
name: Apocarboxylase formation
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR URIt5le
name: uridine transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is described by: ECO:0000134
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
type: Reaction
is: SBO:0000185

metaM acn13acngalgbside hs g
constant: false
is: C00036
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
is: CHEBI:3338
name: sialyl (1,3) sialyl (2,6) galactosylgloboside
initial amount: NaN
initial concentration: 1.0
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110041#_b29d464e_06f1_4fb1_a414_0ffd57dcfc52
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:J03866
type: Species
name: _J03866_1_m
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM arg L c
name: L-argininium(1+)
initial concentration: 1.0
is: CHEBI:32682
is: HMDB00517
boundary condition: false
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR GLYCt
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: glycerol transport via channel

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR GALGALGALTHCRMte
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000185
name: galgalgalthcrm hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
type: Reaction

metaM ddcacoa m
is: C01832
constant: false
is: CHEBI:57375
initial concentration: 1.0
initial amount: NaN
is: HMDB03571
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaR B MANNASEly
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.25
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
name: beta-mannosidase, lysosomal
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#

metaM HC02205 e
is: CHEBI:28099
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: prostaglandin-b2
has only substance units: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM 7dhf c
is: HMDB06559
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a471ad65_b800_4332_a91e_9c621abe2fa8
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: DGKH
is encoded by: hsa:160851
constant: false
boundary condition: true
is: Q86XP1

metaR PSt3
reactant: MODEL1310110041#
is described by: ECO:0000269
name: phosphatidylserine transport
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaM Lpipecol x
is: HMDB00716
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
name: L-pipecolic acid
is: CHEBI:30913
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_251e162a_5c18_4b59_936e_98cea7eb4392
initial concentration: NaN
is: P28332
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:130
is: SBO:0000252
initial amount: NaN
name: ADH6

metaM paf hs e
has only substance units: false
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
constant: false
initial amount: NaN
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
is: CHEBI:36707
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_2ca1bffc_f6c8_4c4f_80e5_562802378f9e
boundary condition: true
is encoded by: hsa:4714
name: NDUFB8
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: O95169
constant: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR r0668
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
kinetic law: MODEL1310110041#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
fast: false
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_b4219350_8d57_4219_bd63_69112ceaaa43
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P51841
is encoded by: hsa:2986
constant: false
type: Species
name: GUCY2F

metaM 3mop e
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28654

metaM ksi deg1 e
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00211
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17268

metaR HSD3A2r
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reactant: MODEL1310110041#
fast: false
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_5127a220_85b0_472f_b2fe_288b815369f6
name: TXNRD1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:7296
type: Species
constant: false
has only substance units: false

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
reactant: MODEL1310110041#
name: blood group intracellular transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
product: MODEL1310110041#

metaR PROt2r
modifier: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-proline reversible transport via proton symport
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
is described by: ECO:0000304

metaM Asn X Ser Thr r
is: CHEBI:28938
is: C01342
initial concentration: 1.0
name: protein-linked asparagine residue (N-glycosylation site)
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00051
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_48d81a26_dab5_44cf_97f6_2b47373359b4
is: SBO:0000252
constant: false
is encoded by: hsa:221
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P43353
name: ALDH3B1

metaR NCKt
name: Na+/Ca2+-K+ exchange
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110041#
is: SBO:0000185
reversible: true
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaR ORNt4m
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000185
name: ornithine mitochondrial transport exchange with citruline
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_269ac4e5_3d56_4cfd_bfdc_d9f04e6d2029
name: ALDH1A3
is encoded by: hsa:220
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P47895
type: Species
is: SBO:0000252
initial amount: NaN

metaR PCHOLP hs
name: choline phosphatase
modifier: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4

http://identifiers.org/biomodels.db/MODEL1310110041#_96f4bfe2_159d_4f0b_84fc_d73557e4ca08
has only substance units: false
is encoded by: hsa:953
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: ENTPD1
is: Q86VV3

metaM paf hs c
has only substance units: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:36707
is: SBO:0000247
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_da86a2e7_96a7_4784_8855_025a414a21b4
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:219
is: SBO:0000252
has only substance units: false
name: ALDH1B1
is: P30837

metaM pe hs r
has only substance units: false
name: phosphatidylethanolamine
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

metaR LEUKTRF4t
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110041#
reversible: true

metaM s7p c
is: CHEBI:57483
constant: false
boundary condition: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Sedoheptulose 7-phosphate
is: HMDB01068
type: Species
is: C05382
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_0e225043_4903_49bd_9f7f_1e39f77319f0
constant: false
boundary condition: true
has only substance units: false
type: Species
name: FAH
is: P16930
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2184

metaR CYSGLTH
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000176
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: true

metaM leuktrB4 e
has only substance units: false
type: Species
is: CHEBI:57461
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: leukotriene B4(1-)
is: HMDB01085
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

metaR PGCD
reversible: false
modifier: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.95
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
name: phosphoglycerate dehydrogenase
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_babcdbb3_d43b_4cb9_a44b_78c4abade53a
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DPYSL2
is encoded by: hsa:1808
constant: false
type: Species
is: SBO:0000252
is: B4DR31

metaM lnlccrn c
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
constant: false
is: SBO:0000247
is: HMDB06469
initial amount: NaN

metaR FPGS5m
reactant: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is version of: http://identifiers.org/ec-code/6.3.2.17
name: folylpolyglutamate synthetase (DHF), mitochondrial
modifier: MODEL1310110041#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_818f93f4_6fd0_4631_8cc7_8f551d7d8e06
is: SBO:0000252
type: Species
is: E9KL44
has only substance units: false
constant: false
name: HADHA
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3030

metaM ksii core2 deg1 l
is: HMDB00868
constant: false
is: CHEBI:57737
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_83e1728b_1857_4579_a52a_f3072f566da5
is encoded by: hsa:5053
initial amount: NaN
boundary condition: true
constant: false
is: P00439
has only substance units: false
type: Species
initial concentration: NaN
name: PAH
is: SBO:0000252

metaR TCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
reversible: true
type: Reaction
fast: false
name: bile acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM ibcoa m
initial concentration: 1.0
is: CHEBI:57338
boundary condition: false
type: Species
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
name: isobutyryl-CoA(4-)
initial amount: NaN
is: HMDB01243
has only substance units: false
is: SBO:0000247

metaR FACOAL160i
product: MODEL1310110041#
is: SBO:0000176
reversible: false
name: C160 fatty acid activation
type: Reaction
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
fast: false

metaM xylu L c
initial amount: NaN
constant: false
type: Species
is: HMDB00751
name: L-xylulose
has only substance units: false
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0
is: CHEBI:17399
is: SBO:0000247

metaM 3mop c
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: HMDB00491
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28654
initial amount: NaN

metaM lnlnca c
is: HMDB01388
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:32387
name: alpha-linolenate

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaM L2aadp6sa c
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: CHEBI:17917
type: Species
has only substance units: false
name: L-allysine
is: HMDB01263
initial amount: NaN
initial concentration: 1.0

metaR BTND1n
is version of: http://identifiers.org/ec-code/3.5.1.12
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
reactant: MODEL1310110041#
name: biotinidase (biotin), nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_4ac962a9_9900_4587_af91_eab62b474186
initial amount: NaN
type: Species
constant: false
is: Q16774
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2987
is: SBO:0000252
name: GUK1

metaM ttdca c
is: CHEBI:30807
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00806
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
type: Species
name: myristate

metaM cdp c
initial concentration: 1.0
is: HMDB01546
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
initial amount: NaN
is: C00112
name: CDP
has only substance units: false

metaR PI45PLC
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110041#
reversible: false

metaR FACOAL140i
name: fatty-acid--CoA ligase (tetradecanoate)
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110041#
reversible: false
kinetic law: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR

metaM rib D e
initial amount: NaN
constant: false
is: HMDB00283
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
is: CHEBI:16988
name: D-ribose

metaR INSTt4
fast: false
name: inositol transport via sodium symport
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_857ba51b_0097_4364_a54f_cf6dbcbca3b9
constant: false
name: RDH14
is encoded by: hsa:57665
boundary condition: true
is: SBO:0000252
type: Species
is: Q9HBH5
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0669
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
is: SBO:0000176
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
fast: false
kinetic law: MODEL1310110041#

metaM leuktrB4 c
type: Species
is: CHEBI:57461
boundary condition: false
constant: false
initial amount: NaN
name: leukotriene B4(1-)
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
has only substance units: false
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110041#_0f78ed12_38c1_4ea0_b7b3_0d45f37663eb
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:28231
has only substance units: false
boundary condition: true
name: SLCO4A1
initial amount: NaN
type: Species
constant: false
is: Q96BD0

metaR RE2659R
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
kinetic law: MODEL1310110041#
name: RE2659

http://identifiers.org/biomodels.db/MODEL1310110041#_c0a6ac8e_d164_4a8e_af96_d2ac1a7f200c
is: SBO:0000252
name: _AL048840_1_c
initial concentration: NaN
is encoded by: hsa:AL048840
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM dhor S c
initial amount: NaN
is: HMDB03349
initial concentration: 1.0
is: CHEBI:30864
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
name: (S)-dihydroorotate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_f308f11e_44ed_4ff2_8347_de20d3d30265
constant: false
is: B2RDZ2
name: RFK
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:55312
type: Species
initial concentration: NaN

metaR UMPK7n
is: SBO:0000176
modifier: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000269
name: UMP kinase (dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110041#

metaM HC01223 m
boundary condition: false
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
constant: false
is: CHEBI:57340
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047

metaM acgam6p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57513
is: SBO:0000247
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: HMDB01062
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e6f5c132_6a2d_451f_9d5a_9a308443e5c9
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:50940
has only substance units: false
boundary condition: true
type: Species
name: PDE11A
initial amount: NaN
is: Q9HCR9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:26174
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
name: I-antigen
has only substance units: false

metaM fum c
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
is: SBO:0000247
is: C00122
is: CHEBI:29806
constant: false
is: HMDB00134
type: Species
initial amount: NaN
name: Fumarate
boundary condition: false

metaM ksi deg17 l
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial amount: NaN
name: keratan sulfate I, degradation product 17
type: Species
is: CHEBI:12936
boundary condition: false

metaR r0434
is described by: ECO:0000000
fast: false
modifier: MODEL1310110041#
reversible: true
is: SBO:0000176
reactant: MODEL1310110041#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaM lnlnca e
is: SBO:0000247
initial amount: NaN
is: CHEBI:32387
initial concentration: 1.0
boundary condition: false
name: alpha-linolenate
has only substance units: false
constant: false
type: Species
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-

metaM tcynt m
is: CHEBI:18022
has only substance units: false
is: HMDB01453
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: thiocyanate
type: Species
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaM rib D c
boundary condition: false
is: CHEBI:16988
initial concentration: 1.0
initial amount: NaN
is: HMDB00283
constant: false
name: D-ribose
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_97d1580c_f233_41f4_877d_14eb3fb2c1bb
name: PDE9A
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152

metaM cdp e
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
constant: false
is: CHEBI:58069
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: CDP(3-)
is: HMDB01546

metaR RE1520M
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110041#
name: RE1520
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_01452d8c_76c7_4c09_9342_efd25dcfcfed
is: SBO:0000252
name: CDIPT
is: O14735
boundary condition: true
has only substance units: false
is encoded by: hsa:10423
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_0e9c5b48_4200_4b9e_ab2d_d84a4ca09a5b
constant: false
boundary condition: true
is: A6NFM2
name: PYCR1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5831

metaM ksii core2 deg9 l
initial concentration: 1.0
constant: false
notes: FORMULA: C30H50N3O20X CHARGE: 0
initial amount: NaN
is: CHEBI:12936
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 9
is: HMDB00143
is: SBO:0000247
type: Species
has only substance units: false

metaR GASNASEly
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110041#
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.5.1.26
is described by: ECO:0000000
is: SBO:0000176

metaR BIOCYTtn
name: biocytin transport, nuclear
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
product: MODEL1310110041#
is described by: ECO:0000000
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110041#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_1a61f92f_5b31_42a8_8abb_d87795c03695
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:771
name: CA12

metaR r1941
fast: false
kinetic law: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110041#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000

metaR r0911
reactant: MODEL1310110041#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
name: Facilitated diffusion
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true

metaR G14Tg
kinetic law: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_e0f9903f_e314_4296_9430_a44277f1b912
has only substance units: false
is: Q96QD8
type: Species
initial amount: NaN
boundary condition: true
name: SLC38A2
is encoded by: hsa:54407
is: SBO:0000252
initial concentration: NaN
constant: false

metaM leu L e
is: CHEBI:15603
has only substance units: false
boundary condition: false
name: L-leucine
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

http://identifiers.org/biomodels.db/MODEL1310110041#_7c010805_9614_4246_b838_fccb515baf0c
is: Q9P1E4
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4122
constant: false
initial amount: NaN
name: MAN2A2
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_d92f6f1d_b357_4d2f_bc0c_ef985774c531
is: SBO:0000252
initial amount: NaN
is: Q9BV79
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: MECR
type: Species
is encoded by: hsa:51102

http://identifiers.org/biomodels.db/MODEL1310110041#_ff473bc7_8e6f_4686_850a_57cde40ff8fa
is encoded by: hsa:374907
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q7Z7M8
has only substance units: false
boundary condition: true
name: B3GNT8

metaM HC02205 c
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
initial concentration: 1.0
is: CHEBI:28099

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_2fe2449f_3615_428a_92df_fee8ee23316d
boundary condition: true
name: ACP1
initial amount: NaN
is encoded by: hsa:52
has only substance units: false
type: Species
initial concentration: NaN
is: P24666
is: SBO:0000252
constant: false

metaM 7dhf e
name: heptaglutamyl folate (DHF)
is: HMDB06559
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_14fcd6a9_fc61_4703_acae_2640c391d701
initial concentration: NaN
is encoded by: hsa:6576
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: D9HTE9
constant: false
name: SLC25A1

metaR XYLTt
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion

http://identifiers.org/biomodels.db/MODEL1310110041#_0de6c4bb_bb65_44a4_b99b_fe101bd8d33f
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:U37519
is: SBO:0000252
initial amount: NaN
type: Species
name: _U37519_1_e

metaR F1PGT
name: fucose-1-phosphate guanylyltransferase
type: Reaction
modifier: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.7.30
fast: false
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176

metaM HC01403 m
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
constant: false
is: CHEBI:28325

metaR 3AIB Dtm
is: SBO:0000185
kinetic law: MODEL1310110041#
type: Reaction
name: transport of 3aib_D into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
reactant: MODEL1310110041#
fast: false
reversible: true
product: MODEL1310110041#
is described by: ECO:0000134

metaR PRASCS
is version of: http://identifiers.org/ec-code/6.3.2.6
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
modifier: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_095eb696_5f47_4a93_8ed2_9f064bfbc183
is: SBO:0000252
type: Species
is encoded by: hsa:6532
initial concentration: NaN
is: P31645
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLC6A4
constant: false

metaR SUCCTD
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR r2331
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR ABO6g
type: Reaction
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.37
kinetic law: MODEL1310110041#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110041#

metaR r0801
fast: false
modifier: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000185
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is described by: ECO:0000000
kinetic law: MODEL1310110041#

metaR SADT
kinetic law: MODEL1310110041#
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
fast: false
reversible: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110041#

metaR CYTDK1
fast: false
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: ATPcytidine 5-phosphotransferase
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000254
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_99511e9f_17dc_41f5_a12f_deec904c209f
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: O95528
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:81031
name: SLC2A10

metaR SPHS1Pte
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a185ff2d_8637_4393_ab19_ecc4a294d17d
is encoded by: hsa:2686
name: GGT7
is: A0PJJ9
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaR FUMSO4tm
modifier: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110041#
name: Fumarate:sulfate antiport, mitochondrial
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_0799af6e_8b2b_4421_a9bc_423e6f6a644e
initial concentration: NaN
name: CHST5
initial amount: NaN
type: Species
is: Q9GZS9
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23563

metaR PCHOLPm hs
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: false
is: SBO:0000176
fast: false
name: choline phosphatase
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.4.4
modifier: MODEL1310110041#

metaR r0913
kinetic law: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true

metaR r2330
kinetic law: MODEL1310110041#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_639fd87c_d54e_4240_8b3a_313a1b2111f8
is: SBO:0000252
is encoded by: hsa:AI926493
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: _AI926493_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_acf276e0_5abd_4eff_8592_4e346747d6d0
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AA532636_1_m
has only substance units: false
type: Species
is encoded by: hsa:AA532636
initial amount: NaN
constant: false

metaM amet m
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
has only substance units: false
name: S-Adenosyl-L-methionine
is: SBO:0000247
is: CHEBI:15414
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01185

metaM ksi pre9 g
has only substance units: false
type: Species
initial amount: NaN
is: C00130
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
constant: false
name: keratan sulfate I biosynthesis, precursor 9

metaM cdpchol c
name: CDPcholine
type: Species
initial amount: NaN
is: HMDB01413
is: SBO:0000247
has only substance units: false
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
constant: false
initial concentration: 1.0
is: CHEBI:16436
boundary condition: false

metaM chol e
name: Choline
initial concentration: 1.0
is: CHEBI:15354
is: HMDB00097
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00114

metaM pser L c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: CHEBI:15811
name: O-Phospho-L-serine
is: HMDB01721

metaM ksi pre1 g
boundary condition: false
is: HMDB00175
is: CHEBI:58053
is: C00130
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 1
constant: false
type: Species
notes: FORMULA: C79H129N5O57X CHARGE: -1
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_ddb0d8db_3ebc_401c_9de0_c3b02ecdda88
boundary condition: true
type: Species
is encoded by: hsa:51251
is: SBO:0000252
is: Q9H0P0
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: NT5C3
constant: false

metaR HOMt4
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110041#
fast: false
name: L-homoserine via sodium symport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#

metaR ENGASE3ly
type: Reaction
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110041#
kinetic law: MODEL1310110041#

metaR RETHe
name: retinyl ester hydrolase, extracellular
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176

metaR RAI2
reactant: MODEL1310110041#
product: MODEL1310110041#
reversible: true
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176

metaR GLCt4
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110041#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: glucose transport via sodium symport
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#

metaM ksi pre33 g
name: keratan sulfate I biosynthesis, precursor 33
is: C00130
initial amount: NaN
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00175
constant: false
boundary condition: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11

http://identifiers.org/biomodels.db/MODEL1310110041#_4b8a6a37_41c4_4abd_9845_7dd154784004
name: SLC14A2
constant: false
initial concentration: NaN
is encoded by: hsa:8170
is: Q15849
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaM 3mop m
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28654
is: SBO:0000247
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: HMDB00491
has only substance units: false

metaR RE2269E
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is: SBO:0000176
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
name: RE2269
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.21.39

metaR BILIRED
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.24
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
name: Nad(p)h biliverdin reductase

http://identifiers.org/biomodels.db/MODEL1310110041#_71daf53f_8b2c_4bfd_b6b1_8285882a8b5a
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:293
boundary condition: true
has only substance units: false
type: Species
name: SLC25A6
constant: false
initial amount: NaN
is: Q6I9V5

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR FATP2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
name: fatty acid electroneutral transport
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110041#
product: MODEL1310110041#

metaR TAURCHAe
name: exit of taurine from the enterocytes
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000134
type: Reaction
reversible: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
kinetic law: MODEL1310110041#
is: SBO:0000185

metaR GDPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
name: GDP intracellular transport
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000000
type: Reaction
fast: false

metaM cholp c
boundary condition: false
is: CHEBI:295975
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

http://identifiers.org/biomodels.db/MODEL1310110041#_f48abb41_c2bf_4017_99ea_a346552c30a9
has only substance units: false
is: P42126
initial amount: NaN
initial concentration: NaN
name: ECI1
is encoded by: hsa:1632
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaR MALtm
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
name: malate transport, mitochondrial
reactant: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
fast: false

metaM occoa m
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C01944
constant: false
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: CHEBI:57386

http://identifiers.org/biomodels.db/MODEL1310110041#_062d872a_9064_43c0_a550_01fadceec1d5
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: HADHA
is encoded by: hsa:3030
is: E9KL44
is: SBO:0000252
boundary condition: true

metaM amet c
constant: false
boundary condition: false
is: C00019
is: SBO:0000247
initial amount: NaN
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01185
name: S-Adenosyl-L-methionine

http://identifiers.org/biomodels.db/MODEL1310110041#_005d9c6b_b833_43e1_97a3_b620d9360eb6
initial concentration: NaN
is encoded by: hsa:H77542
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: _H77542_1_r
initial amount: NaN

metaR 2OXOADOXm
product: MODEL1310110041#
fast: false
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.61
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110041#

metaM glu L c
initial amount: NaN
name: L-glutamate(1-)
is: SBO:0000247
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:29985
boundary condition: false
is: HMDB00148

http://identifiers.org/biomodels.db/MODEL1310110041#_511b0c1a_5555_4642_a942_8a5d987ef4ba
has only substance units: false
name: DCTD
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1635
is: P32321
boundary condition: true
type: Species
constant: false

metaR r1893
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_c1ad7b28_2b9d_4bd2_91b7_41bb65849d6b
is: O95498
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8875
name: VNN2
has only substance units: false
is: SBO:0000252

metaM ksii core2 pre9 g
name: keratan sulfate II biosynthesis, precursor 9
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
initial amount: NaN
is: CHEBI:28067
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_31e8d796_95b9_4599_b140_2c89379c5042
has only substance units: false
name: DPYD
is encoded by: hsa:1806
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q12882
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_92b33030_7ecd_4e95_9194_71925340d496
is: SBO:0000252
name: PDE9A
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5152

metaR GCNTg
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
modifier: MODEL1310110041#
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.150
product: MODEL1310110041#
is described by: ECO:0000269
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_f62bb14b_a0e6_4d1d_8bd5_388c7cc52d00
is encoded by: hsa:4967
initial amount: NaN
initial concentration: NaN
is: Q02218
constant: false
is: SBO:0000252
has only substance units: false
name: OGDH
boundary condition: true
type: Species

metaR PHEMEt
name: heme transport
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reversible: false
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction

metaR ETOHt
fast: false
name: ethanol reversible transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110041#

metaM mescon m
is: SBO:0000247
is: HMDB00749
boundary condition: false
type: Species
is: CHEBI:36986
name: Mesaconate
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a3e29dc0_cf18_41c5_bb50_44fbbaef55e3
has only substance units: false
constant: false
is: Q9NY64
type: Species
initial amount: NaN
name: SLC2A8
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29988
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_034eedf5_de18_442a_bcb5_a959a751f4af
initial concentration: NaN
has only substance units: false
name: B3GALT5
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:10317

metaM CE5853 e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:12947
name: alpha-CEHC-glucuronide
is: SBO:0000247
boundary condition: false
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853

metaR r2100
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR VALTA
type: Reaction
name: valine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110041#
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_f0aef282_49ed_46bd_88bc_57a8bfaee6b4
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: ALDH3B2
is: P48448
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:222

metaM chol r
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00097
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline

metaM i c
boundary condition: false
name: iodide
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB12238
is: CHEBI:16382
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
has only substance units: false

metaR GALASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110041#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_d745ee48_a52a_475a_a628_c0856b56deb5
is encoded by: hsa:89874
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: SLC25A21
boundary condition: true
initial amount: NaN
is: G3V4L5

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaR FACOAL181i
name: C181 fatty acid activation
reactant: MODEL1310110041#
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110041#
is: SBO:0000176
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
kinetic law: MODEL1310110041#
fast: false

metaR PYDXtr
name: Pyridoxal transport
reactant: MODEL1310110041#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_a1438d61_9f0a_4e6d_80af_088e1e17b035
is: SBO:0000252
name: B4GALT5
initial concentration: NaN
is: O43286
is encoded by: hsa:9334
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaM lac D c
initial concentration: 1.0
name: (R)-lactate
is: CHEBI:16004
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial amount: NaN
is: HMDB01311
constant: false
boundary condition: false

metaM ksi deg1 l
is: CHEBI:18287
boundary condition: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00174
name: keratan sulfate I, degradation product 1
initial amount: NaN

metaR RAI1
reversible: true
kinetic law: MODEL1310110041#
name: retinal isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000176
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_61e0156d_f6fd_4ded_8c7e_f6c8846f563d
type: Species
boundary condition: true
is encoded by: hsa:4351
initial concentration: NaN
constant: false
is: SBO:0000252
is: P34949
has only substance units: false
initial amount: NaN
name: MPI

metaR GACMTRc
name: guanidinoacetate N-methyltransferase (c)
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
fast: false
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.1.1.2
product: MODEL1310110041#
type: Reaction
reversible: true

metaM leu L c
is: CHEBI:15603
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
has only substance units: false
is: HMDB00687
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species

metaM hdca e
is: C00249
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00220
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1
initial concentration: 1.0
type: Species
name: Hexadecanoate (n-C16:0)
is: CHEBI:0

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
type: Reaction
kinetic law: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110041#
product: MODEL1310110041#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110041#_d6db35a5_eb7a_48f4_affd_30e33156b84f
name: FLAD1
is encoded by: hsa:80308
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: Q8NFF5

http://identifiers.org/biomodels.db/MODEL1310110041#_daac3ab9_5cc7_4bdb_89f3_d1dbe5f16785
initial concentration: NaN
constant: false
is: SBO:0000252
name: GPX2
type: Species
is encoded by: hsa:2877
boundary condition: true
has only substance units: false
is: P18283
initial amount: NaN

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR ARACHCPT2
type: Reaction
is: SBO:0000176
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
name: carnitine transferase
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110041#
is described by: ECO:0000000

metaR RE1526M
modifier: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
is described by: ECO:0000000
name: RE1526
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r2101
modifier: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110041#
reversible: true
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000

metaM pail345p hs c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57836
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ffd80d43_6c85_430e_a190_709c3ed07236
constant: false
is encoded by: hsa:3163
is: P30519
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: HMOX2
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_9fe4e3bb_486b_43af_9d2b_c7ee5feeae2b
boundary condition: true
is: SBO:0000252
is: P54687
constant: false
is encoded by: hsa:586
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: BCAT1

http://identifiers.org/biomodels.db/MODEL1310110041#_835d1f2f_1599_4044_934b_9d2568f8f188
is: SBO:0000252
name: CA1
initial concentration: NaN
initial amount: NaN
constant: false
is: P00915
is encoded by: hsa:759
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_33f97361_a0df_42a5_b968_6a92f4b99e5e
is: P49441
boundary condition: true
is: SBO:0000252
name: INPP1
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3628

http://identifiers.org/biomodels.db/MODEL1310110041#_b390133e_7022_403d_9ad2_7e337d916cf0
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: DBH
boundary condition: true
is: P09172
constant: false
is encoded by: hsa:1621

metaR P5CR
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
name: pyrroline-5-carboxylate reductase
reactant: MODEL1310110041#
fast: false
product: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:

metaM ppa c
initial amount: NaN
is: CHEBI:17272
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
name: propionate
is: SBO:0000247

metaM 5mta e
is: HMDB01173
name: 5-Methylthioadenosine
constant: false
type: Species
boundary condition: false
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: C00170
has only substance units: false
is: CHEBI:17509
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_68422a28_beb1_4218_9006_08786a3b2707
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55350
initial amount: NaN
boundary condition: true
type: Species
name: VNN3
constant: false

metaR r0559
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:61648
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r1259
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110041#
reversible: false
is: SBO:0000176
fast: false
name: EC:6.2.1.3
kinetic law: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_18707922_4f32_48f0_8a2d_af7923d46bd8
constant: false
initial concentration: NaN
initial amount: NaN
name: TM7SF2
is: SBO:0000252
is encoded by: hsa:7108
is: O76062
has only substance units: false
boundary condition: true
type: Species

metaM nh4 c
initial amount: NaN
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
is: C01342
name: Ammonium
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110041#_a683a837_d6d5_4b7f_834c_18016571a0f6
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: _AI620219_1_e
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI620219
is: SBO:0000252

metaR LAPCOAl
is described by: ECO:0000304
modifier: MODEL1310110041#
name: lysosomal acid phosphorylase (CoA)
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
fast: false
kinetic law: MODEL1310110041#
reversible: false
is: SBO:0000176
product: MODEL1310110041#
type: Reaction

metaR r1819
is: SBO:0000185
modifier: MODEL1310110041#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110041#
reactant: MODEL1310110041#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110041#_25061272_9846_4d64_9711_4a378e7a9c75
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _NOS2A_1_c
type: Species
is encoded by: hsa:NOS2A
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_8490a227_1836_422a_86d9_fd79df0db6e7
constant: false
is: SBO:0000252
name: _R51273_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:R51273

http://identifiers.org/biomodels.db/MODEL1310110041#_a580edf0_2af0_4866_a0c2_b3b7107194c9
initial concentration: NaN
is encoded by: hsa:3417
is: O75874
name: IDH1
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaM gthox m
is: HMDB03337
is: CHEBI:58297
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_5aeae6d6_b54a_44e6_a106_7322dd3484b0
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: Q14916
is encoded by: hsa:6568
is: SBO:0000252
initial concentration: NaN
name: SLC17A1
has only substance units: false

metaM lnlccrn m
initial concentration: 1.0
type: Species
is: HMDB06469
initial amount: NaN
boundary condition: false
name: Linoleyl carnitine
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
has only substance units: false
constant: false

metaR EBASTINEtr
product: MODEL1310110041#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
name: xenobiotic transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

metaM i e
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
has only substance units: false
is: CHEBI:16382
name: iodide
initial concentration: 1.0
boundary condition: false

metaR G14T12g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110041#

metaR ARACHCPT1
fast: false
reversible: false
modifier: MODEL1310110041#
name: carnitine transferase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_dc9059df_c63b_4f9e_a887_f61890edd647
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4711
type: Species
boundary condition: true
constant: false
name: NDUFB5
is: O43674

metaR RE2541E
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
name: RE2541
fast: false
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
is: SBO:0000176
modifier: MODEL1310110041#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110041#_a36b26de_5c14_4933_a46f_e5bd8e80a35f
is encoded by: hsa:1962
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9NY65
type: Species
initial amount: NaN
constant: false
name: EHHADH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_ca6167e3_ba1e_4a15_b69d_f5adc76bad3e
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:26
is: P19801
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: ABP1
constant: false

metaM ksi deg24 l
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
initial amount: NaN
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 24

http://identifiers.org/biomodels.db/MODEL1310110041#_0d590e44_99fa_4c6e_9c56_a9d78f6c01d6
name: _D29675_1_e
has only substance units: false
is encoded by: hsa:D29675
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR GGH 6THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
name: Gamma-glutamyl hydrolase (6THF), extracellular
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110041#
fast: false
type: Reaction

metaM hdca c
constant: false
initial concentration: 1.0
boundary condition: false
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:7896
is: SBO:0000247

metaR PPItx
product: MODEL1310110041#
name: Diphosphate transporter, peroxisome
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
fast: false

metaR r0558
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110041#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaM 44mctr r
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023
is: CHEBI:17813
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
initial concentration: 1.0
type: Species
constant: false

metaR DOLP Uter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
name: dolichol phosphate flippase (uterus)
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110041#_cb7f0f7c_6d1d_4c31_bf51_e7abdca3be26
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: AACS
is encoded by: hsa:65985
is: Q86V21
has only substance units: false
is: SBO:0000252
constant: false

metaR BILGLCURtr
reversible: true
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_d6ee6e7d_218d_430a_b39b_cfd2bde46076
name: LDHB
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3945
initial concentration: NaN
is: P07195
has only substance units: false
constant: false
initial amount: NaN

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaR OLEICFATPtc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM CE5118 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
has only substance units: false
constant: false
is: CHEBI:12947
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_e10195e8_950f_4dfe_a150_f240ce102c49
initial concentration: NaN
name: UPP1
initial amount: NaN
is: Q16831
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:7378
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_55949102_ab7c_420c_a78e_6adeb08d0ea4
is: P31040
type: Species
initial amount: NaN
constant: false
name: SDHA
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6389

metaM Asn X Ser Thr l
is: C01342
initial amount: NaN
is: HMDB00051
boundary condition: false
is: CHEBI:28938
constant: false
notes: FORMULA: XH CHARGE: 0
name: protein-linked asparagine residue (N-glycosylation site)
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaM lnlnca l
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: HMDB01388
boundary condition: false
is: CHEBI:32387
name: alpha-linolenate
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

metaR r0160
reactant: MODEL1310110041#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.1.3.2
product: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51

metaM h2o2 c
initial amount: NaN
is: C00027
initial concentration: 1.0
is: CHEBI:16240
name: Hydrogen peroxide
is: HMDB03125
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_09156557_7b1d_4ae8_bb9b_5d83ec473a25
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:55293
initial concentration: NaN
is: Q8IX04
initial amount: NaN
constant: false
has only substance units: false
name: UEVLD

metaR FUT911g
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110041#
reversible: false
name: Alpha-(1,3)-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.152
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176

metaR PRO1x
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reactant: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000176
name: L-ProlineNAD+ 5-oxidoreductase
reversible: false
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.99.8

metaR 13DAMPPOX
product: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
is described by: ECO:0000212
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110041#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110041#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

http://identifiers.org/biomodels.db/MODEL1310110041#_ff3c2c7a_0107_4e48_ad73_638df5fcca91
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:8802
boundary condition: true
is: P53597
name: SUCLG1
has only substance units: false
initial amount: NaN

metaR LTC4CP
is described by: ECO:0000000
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
name: Leukotriene C4 carboxypeptidase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is: SBO:0000176
reversible: true

metaM 34dhmald c
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: C05577
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
is: http://identifiers.org/pubchem.compound/7903

http://identifiers.org/biomodels.db/MODEL1310110041#_eb5b3cfb_95c1_4f32_b344_80d5aed7b569
name: GUCY1B3
initial concentration: NaN
is: Q02153
constant: false
initial amount: NaN
is encoded by: hsa:2983
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR S6T8g
modifier: MODEL1310110041#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_4a88d1e8_7d5e_4e51_bc0b_5b4aa74dc75c
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2678
name: GGT1
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P19440

http://identifiers.org/biomodels.db/MODEL1310110041#_d5ae291d_935c_41c1_b7ab_0800bf027948
is encoded by: hsa:8694
type: Species
is: SBO:0000252
has only substance units: false
name: DGAT1
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: O75907

metaM chol n
is: HMDB00097
name: choline
is: SBO:0000247
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110041#_2160125a_e1f0_4392_8bb0_03c7bd561494
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: TXNRD1
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:7296

http://identifiers.org/biomodels.db/MODEL1310110041#_f234edc6_dfe2_434d_9a50_2355f6991588
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:NM 013421
name: _NM_013421_1_m
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR APOC LYS BTNPm
is: SBO:0000176
name: proteolysis of apoC-Lys-btn, mitochondrial
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110041#

metaR TDPm
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
product: MODEL1310110041#
is: SBO:0000176
name: thiamin pyrophosphatase, mitochondrial
kinetic law: MODEL1310110041#

metaR DPCOAPPe
name: Pyrophasphatase (dephospho-CoA, extracellular)
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110041#
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110041#
reversible: false
type: Reaction

metaM 5mta c
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01173
is: CHEBI:17509
is: SBO:0000247
is: C00170
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
name: 5-Methylthioadenosine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_2ef26f9d_606f_4d2e_8f20_20dc9f82ba8d
boundary condition: true
name: LHPP
is encoded by: hsa:64077
is: Q9H008
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaR r1899
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110041#
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: false
fast: false
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaM glu L e
is: HMDB00148
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: L-glutamate(1-)
initial amount: NaN
is: CHEBI:29985
initial concentration: 1.0

metaM val L m
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00883
name: L-valine
has only substance units: false
is: CHEBI:16414

http://identifiers.org/biomodels.db/MODEL1310110041#_039b7533_3ddf_41d2_965c_37250a739b18
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: Q5K4L6
name: SLC27A3
type: Species
initial amount: NaN
is encoded by: hsa:11000
boundary condition: true

metaR G14T8g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110041#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_31dacc9b_1c2b_487e_aba3_d0d90c3bf3e2
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:3712
is: B3KVI7
type: Species
initial amount: NaN
initial concentration: NaN
name: IVD
constant: false

metaM chol m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: choline
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: CHEBI:15354
initial amount: NaN
boundary condition: false
is: HMDB00097

metaM h2o2 e
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
is: HMDB03125
is: SBO:0000247
is: CHEBI:16240
constant: false
name: hydrogen peroxide
initial amount: NaN

metaR GALASE18ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110041#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
type: Reaction

metaM HC01410 m
initial amount: NaN
type: Species
name: (2E)-Hexenoyl-CoA
constant: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 29
has only substance units: false

metaM 3mgcoa m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
type: Species
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: SBO:0000247
constant: false
is: HMDB01057
is: CHEBI:57346
boundary condition: false

metaR NRPPHRtu
modifier: MODEL1310110041#
name: Norepinephrine uniport
fast: false
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
type: Species
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
initial concentration: 1.0
name: Type IIIAb
is: CHEBI:57288
initial amount: NaN
is: HMDB01206
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

metaR r2328
is: SBO:0000185
product: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_6d0a5adc_53c7_43b2_95b5_0ce07579e9f0
initial concentration: NaN
constant: false
is encoded by: hsa:51703
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ACSL5
is: Q9ULC5
type: Species

metaM prostge1 e
has only substance units: false
type: Species
constant: false
is: CHEBI:57397
is: SBO:0000247
initial amount: NaN
name: prostaglandin E1(1-)
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
is: HMDB01442

metaM g2m8mpdol U r
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
is: CHEBI:59093
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ach e
name: acetylcholine
boundary condition: false
constant: false
is: HMDB00895
has only substance units: false
is: CHEBI:15355
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR r1260
kinetic law: MODEL1310110041#
fast: false
product: MODEL1310110041#
is described by: ECO:0000000
name: EC:6.2.1.3
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM malthp e
boundary condition: false
initial concentration: 1.0
name: maltoheptaose
is: SBO:0000247
is: C01936
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
constant: false
is: http://identifiers.org/pubchem.compound/5041

metaR ARACHDt2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110041#
is: SBO:0000185
reversible: true

metaR ACOAD9m
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
type: Reaction
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
reversible: false

metaR DCMPDA
is described by: ECO:0000254
modifier: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.12
reversible: true
name: dCMP deaminase
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176

metaR MALSO3tm
fast: false
name: Malate:sulfite antiport, mitochondrial
modifier: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110041#_c600bd4c_fcd2_4a8a_93a5_37b47f1e13b3
is: P54868
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:3158
type: Species
initial concentration: NaN
name: HMGCS2

metaR HSD3B11
is described by: ECO:0000134
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
kinetic law: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
reversible: false
modifier: MODEL1310110041#
is: SBO:0000176

metaM prgnlone c
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16581
is: HMDB00253
name: pregnenolone
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953

http://identifiers.org/biomodels.db/MODEL1310110041#_b133d902_d1e2_4196_bac3_998f2eb83d7e
is encoded by: hsa:760
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P00918
initial concentration: NaN
name: CA2

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_0befbd87_433a_4d7f_9822_6f7069a446ed
is encoded by: hsa:AA664770
name: _AA664770_1_m
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR G14T9g
reactant: MODEL1310110041#
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_e4dd4629_d103_4478_9ffc_07b989d3873f
type: Species
initial amount: NaN
is: SBO:0000297
has only substance units: false
constant: false
boundary condition: true
has part: P23921
name: RRM1:RRM2
initial concentration: NaN
has part: P31350
is encoded by: hsa:6241
is encoded by: hsa:6240

metaM thmmp c
is: SBO:0000247
type: Species
name: Thiamin monophosphate
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
boundary condition: false
constant: false
is: CHEBI:37575
has only substance units: false
is: HMDB02666
is: C01081
initial concentration: 1.0
initial amount: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_17284e26_f677_4aff_b97f_ceb4fba9a3cf
initial concentration: NaN
is encoded by: hsa:1350
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is: P15954
has only substance units: false
name: COX7C

metaM acnam c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00230
name: N-acetylneuraminate
type: Species
is: CHEBI:35418

metaM 5aop m
initial concentration: 1.0
is: HMDB01149
is: SBO:0000247
name: 5-Amino-4-oxopentanoate
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: C00430
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:17549

metaM dcacoa m
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
is: HMDB06404
is: SBO:0000247
constant: false
is: CHEBI:61430
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)

metaR r2329
kinetic law: MODEL1310110041#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM 3aib D m
is: HMDB02299
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
is: C03265
type: Species
boundary condition: false
name: D-3-Amino-isobutanoate
initial concentration: 1.0

metaM 5hoxindoa c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
has only substance units: false
name: 5-Hydroxyindoleacetate
constant: false
initial amount: NaN
is: CHEBI:27823
boundary condition: false
is: HMDB00763
type: Species

metaR MERCPLACCYSt
is: SBO:0000185
product: MODEL1310110041#
type: Reaction
fast: false
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reversible: false
is described by: ECO:0000000

metaM ksi pre16 g
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial concentration: 1.0
is: C00130
initial amount: NaN
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 16
is: SBO:0000247
is: HMDB00175
constant: false
has only substance units: false
boundary condition: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_a7595372_2cd6_43e7_b291_7d6883fb2b95
constant: false
boundary condition: true
is: P23368
is encoded by: hsa:4200
type: Species
name: ME2
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_ddb4f98f_d0d6_4bd3_89ad_2e215db701b0
type: Species
boundary condition: true
name: TK2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7084
constant: false
has only substance units: false
is: SBO:0000252
is: O00142

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/4.2.1.18
is: SBO:0000176
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110041#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
type: Reaction

metaR r1464
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
name: Active transport
is: SBO:0000185
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_092cb123_f45c_4d18_a274_8c55831f3724
initial amount: NaN
is encoded by: hsa:6526
type: Species
has only substance units: false
boundary condition: true
name: SLC5A3
initial concentration: NaN
is: P53794
is: SBO:0000252
constant: false

metaR biomass reaction
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
reactant: MODEL1310110041#
name: Generic human biomass reaction
product: MODEL1310110041#
type: Reaction

metaR 34HPPte
reversible: true
kinetic law: MODEL1310110041#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
reactant: MODEL1310110041#
fast: false
name: Transport of 3-(4-hydroxyphenyl)pyruvate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR BUP2
modifier: MODEL1310110041#
is: SBO:0000176
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
reactant: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.5.1.6
product: MODEL1310110041#

metaR DNDPt9m
name: dADP transport via dTDP antiport
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110041#
type: Reaction

metaM inost e
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00211
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
is: CHEBI:17268
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_e5b23a37_ec1f_4eb8_8f68_3552da2008f5
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: Q9NPC4
type: Species
is: SBO:0000252
name: A4GALT
boundary condition: true
is encoded by: hsa:53947

metaM ksii core4 pre4 g
constant: false
is: C00130
is: CHEBI:58053
initial concentration: 1.0
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: HMDB00175
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e5d322fa_ea84_4bf7_a471_f9e89efcae28
is: SBO:0000252
initial concentration: NaN
type: Species
is: O95861
has only substance units: false
constant: false
is encoded by: hsa:10380
boundary condition: true
initial amount: NaN
name: BPNT1

metaR r1262
name: EC:6.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110041#

metaM ach c
is: CHEBI:15355
type: Species
is: SBO:0000247
is: HMDB00895
name: acetylcholine
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
constant: false

metaM lnlnca r
is: CHEBI:32387
name: alpha-linolenate
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01388
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a6bc0597_d1a8_44b5_b02e_9b362596a77c
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3074
name: HEXB
is: SBO:0000252
is: P07686
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_f9a1e0cf_232a_4eff_baa7_2047d95c068e
is encoded by: hsa:LOC374569
name: _LOC374569_1_e
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaR RE1691M
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: true
name: RE1691
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.1
is: SBO:0000176
kinetic law: MODEL1310110041#

metaR DINt
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is: SBO:0000185
name: deoxyinosine transport via diffusion
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR UDPG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000134
reversible: true
product: MODEL1310110041#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
modifier: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
name: UDPglucose 4-epimerase

http://identifiers.org/biomodels.db/MODEL1310110041#_4fc1ea66_aa34_478e_8b07_db58d1ebf0cb
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: FOLR1
boundary condition: true
is encoded by: hsa:2348
has only substance units: false
is: SBO:0000252

metaR SPHS1Ptr
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110041#
reversible: true
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
fast: false

metaM dhbpt c
boundary condition: false
is: HMDB00038
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:20680
name: 6,7-dihydrobiopterin

metaR S23T2g
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.4
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
reversible: false
modifier: MODEL1310110041#

metaR r0556
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
product: MODEL1310110041#

metaM strdnc e
name: stearidonic acid C18:4, n-3
is: C16300
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB06547

metaR S6T12g
is: SBO:0000176
product: MODEL1310110041#
modifier: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_8bfd8e6d_1c5d_444a_8c96_efa19ab8d25d
is: Q9Y5P4
is encoded by: hsa:10087
initial concentration: NaN
boundary condition: true
name: COL4A3BP
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaM occoa c
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57386
is: C01944
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_cf71d368_71f1_409b_8197_f0bedb68aef5
name: AKR7A2
type: Species
is: O43488
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8574
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9c8cb838_2bf2_48d9_8e5b_252a6be456c5
name: ALDH9A1
initial amount: NaN
is: P49189
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:223
has only substance units: false

metaR GALASE9ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110041#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110041#
product: MODEL1310110041#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110041#_b9ad523a_ca0a_4fe4_9e0b_075eac971791
initial concentration: NaN
is encoded by: hsa:6523
is: SBO:0000252
name: SLC5A1
is: P13866
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_1d0f4e5a_8666_4f3a_9231_25116a0f4378
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ST6GALNAC2
is: Q9UJ37
is encoded by: hsa:10610
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_ef63c015_d050_403a_a4e6_62f3aba2aa02
is: Q9NRA2
initial concentration: NaN
name: SLC17A5
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:26503
is: SBO:0000252

metaR C204CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
name: arachidonic acid transport into the mitochondria
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110041#
reversible: false
fast: false
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_f45b6d2a_12cd_4c24_b1e1_ab44379d42f5
is: E7EQF2
is encoded by: hsa:54677
name: CROT
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110041#
is: SBO:0000185
kinetic law: MODEL1310110041#
fast: false
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000269
name: Prostaglandin I2 transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_5c3ac766_571e_4056_9864_871d67c9f7cf
name: HSD17B3
is encoded by: hsa:3293
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: P37058
constant: false
has only substance units: false
initial amount: NaN

metaM nh4 e
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00051
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
constant: false

metaM inost c
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
is: HMDB00211
is: CHEBI:17268

metaR ATPtm
kinetic law: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
reversible: false
name: ADP/ATP transporter, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_7eb8d2a9_a87a_4719_b0d5_dfe85d1b0743
name: RRM1
initial concentration: NaN
is: P23921
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6240

metaM n2m2nmn l
has only substance units: false
is: HMDB00939
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
boundary condition: false
is: CHEBI:16680
constant: false
type: Species
notes: FORMULA: C50H84N4O36 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
type: Species
has only substance units: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
name: nLc7Cer
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:26174

metaR SO4tl
reactant: MODEL1310110041#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
name: Sulfate transport (lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
kinetic law: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_68eb4581_aea0_4fc4_9f85_c44b177996c0
name: PCK2
is encoded by: hsa:5106
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q16822
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_f271776b_7b16_4d8a_b9ae_ef7414004c16
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:9377
initial concentration: NaN
type: Species
is: P20674
boundary condition: true
name: COX5A

metaR NAHCO3 HCLt
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
name: bicarbonate transport (HCl/NaHCO3 exchange)
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110041#_6908c2ea_754b_4813_9672_1d6bb011cd75
boundary condition: true
initial concentration: NaN
name: MAT2B:MAT2A
constant: false
is: SBO:0000297
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:27430
has part: Q9NZL9

metaM pe hs e
has only substance units: false
is: SBO:0000247
constant: false
name: phosphatidylethanolamine
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16038
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:61648
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
name: Type IIIAb
is: SBO:0000247
initial amount: NaN

metaR r0156
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110041#
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: false
is: SBO:0000176
fast: false

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
modifier: MODEL1310110041#
name: RE1527
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_08b13c97_53b5_4f1a_b1ad_789a7e7f3da5
name: ACP6
is: Q9NPH0
is encoded by: hsa:51205
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_cc21ae4b_6510_4e24_915d_44667f6ddb17
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7264
is: Q13630
boundary condition: true
name: TSTA3
type: Species
constant: false
has only substance units: false

metaM asp L e
name: L-aspartate(1-)
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:29991
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
is: HMDB00191
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_94fc2dba_e4d2_4ee0_a10b_f4fa32bab2c0
is encoded by: hsa:10678
initial concentration: NaN
is: Q9NY97
has only substance units: false
boundary condition: true
initial amount: NaN
name: B3GNT2
is: SBO:0000252
constant: false
type: Species

metaR r1467
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction
fast: false
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

metaM nm2masn g
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C05884
notes: FORMULA: C42H70N3O30X CHARGE: 0
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_2d99ea70_8838_45d7_b06b_0290e4d76437
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q16836
is encoded by: hsa:3033
boundary condition: true
name: HADH

metaR AG13T15g
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110041#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110041#
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110041#

metaM 4aphdob c
is: SBO:0000247
is: CHEBI:58147
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false
is: HMDB00978
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252

metaR NaKt
is version of: http://identifiers.org/ec-code/3.6.3.9
reversible: false
name: Na+/K+ exchanging ATPase
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
kinetic law: MODEL1310110041#
fast: false
type: Reaction
product: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110041#
modifier: MODEL1310110041#

metaM ivcoa m
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57345
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01113
name: Isovaleryl-CoA
constant: false

metaM ac c
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:30089
initial concentration: 1.0
is: HMDB00042
name: acetate
has only substance units: false
type: Species

metaM 4hphac e
type: Species
name: 4-hydroxyphenylacetate
is: SBO:0000247
is: HMDB00020
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
initial concentration: 1.0
is: CHEBI:48999
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaM gthox e
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58297

metaM strdnc c
is: SBO:0000247
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
name: stearidonic acid C18:4, n-3

metaM meoh c
is: CHEBI:17790
type: Species
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01875
name: methanol
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_b9762783_d15f_48ae_95a6_2e2bd336954b
is: P50747
is encoded by: hsa:3141
has only substance units: false
name: HLCS
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r0157
is version of: http://identifiers.org/ec-code/6.3.4.2
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
reactant: MODEL1310110041#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110041#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_92f21ecb_6812_43ae_a06b_f5795b763eb2
constant: false
is: Q9UN76
type: Species
initial amount: NaN
name: SLC6A14
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11254

metaR NH4tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110041#
name: ammonia peroxisomal transport
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185

metaR r1106
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110041#
type: Reaction

metaM h2o2 m
is: CHEBI:16240
type: Species
boundary condition: false
is: SBO:0000247
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
name: Hydrogen peroxide
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM ksi pre22 g
boundary condition: false
constant: false
type: Species
is: CHEBI:58053
initial amount: NaN
has only substance units: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 22
is: SBO:0000247
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial concentration: 1.0
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110041#_e2720d93_f50a_4b37_ad9a_ff5b919daa4c
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: TK2
type: Species
is: O00142
constant: false
is encoded by: hsa:7084
boundary condition: true

metaR ILETAm
name: isoleucine transaminase, mitochondrial
kinetic law: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
modifier: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_f72eaddf_66e9_499c_9c79_e90de68b490d
constant: false
name: SLC16A1
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6566
is: B4DKS0
has only substance units: false
is: SBO:0000252

metaM pe hs c
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
initial concentration: 1.0
name: phosphatidylethanolamine
is: CHEBI:16038
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
initial amount: NaN
is: CHEBI:57288
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Type IIIAb
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
is: HMDB01206
is: SBO:0000247

metaM ksii core2 pre4 g
initial amount: NaN
notes: FORMULA: C53H86N4O38X CHARGE: -1
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB00175
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
is: CHEBI:58053
initial concentration: 1.0

metaM retinal 11 cis c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: HMDB02152
has only substance units: false
name: 11-cis-retinal
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16066
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_a7b99f99_6eb8_4dc7_a139_fea10bf5951b
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI694761
boundary condition: true
type: Species
name: _AI694761_1_c
is: SBO:0000252
constant: false
initial amount: NaN

metaR ARACHDCOAtx
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110041#
name: fatty acid intracellular transport
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_84d4b8a5_b272_40bc_a0ca_1e6752b41361
is: P22033
constant: false
is encoded by: hsa:4594
type: Species
is: SBO:0000252
name: MUT
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r1109
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
fast: false
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6

metaR r0552
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: true
type: Reaction
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
modifier: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaM asp L c
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
is: HMDB00191
name: L-aspartate(1-)

metaR MTAP
product: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110041#
name: 5'-methylthioadenosine phosphorylase
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (4507.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.4.2.28 Confidence Level: 4 AUTHORS: PMID:16000004,PMID:2543672,PMID:3091600 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.28
type: Reaction
kinetic law: MODEL1310110041#

metaM prostge1 c
constant: false
is: HMDB01442
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57397
initial amount: NaN
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_f770117c_4593_424c_8f0f_a7279454dc91
constant: false
initial concentration: NaN
is: P48448
has only substance units: false
boundary condition: true
is encoded by: hsa:222
initial amount: NaN
name: ALDH3B2
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: nLc8Cer
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26174

metaM pail4p hs c
is: SBO:0000247
type: Species
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
constant: false
is: CHEBI:58178
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaM h2o2 n
is: SBO:0000247
type: Species
name: hydrogen peroxide
boundary condition: false
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
constant: false
is: HMDB03125
initial concentration: 1.0
is: CHEBI:16240

metaR r0009
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110041#
type: Reaction
fast: false
product: MODEL1310110041#

metaM 13 cis retn r
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: 13-cis-retinoate
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
constant: false
is: HMDB06219
has only substance units: false

metaM ac e
constant: false
type: Species
initial amount: NaN
is: CHEBI:30089
is: HMDB00042
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false

metaR MI1PP
reactant: MODEL1310110041#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reversible: false
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
is: SBO:0000176

metaM gthox c
is: C00127
type: Species
name: Oxidized glutathione
is: HMDB03337
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58297
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false

metaM pep m
is: C00074
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: CHEBI:18021
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Phosphoenolpyruvate
type: Species

metaM 4hphac c
initial concentration: 1.0
initial amount: NaN
is: HMDB00020
constant: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:48999
name: 4-hydroxyphenylacetate
has only substance units: false

metaM meoh e
boundary condition: false
is: SBO:0000247
name: methanol
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: CHEBI:17790
is: HMDB01875
has only substance units: false

metaR ALAt4
fast: false
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
reactant: MODEL1310110041#
reversible: false
modifier: MODEL1310110041#
is described by: ECO:0000269
name: Alanine-Sodium symporter
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a4e95367_7068_4d1d_805e_b783f0e542fd
is encoded by: hsa:123041
boundary condition: true
is: SBO:0000252
type: Species
name: SLC24A4
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR r0553
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
product: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
reactant: MODEL1310110041#

metaR TYRt
modifier: MODEL1310110041#
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110041#
name: L-tyrosine transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110041#_b33ab9b8_5e48_446d_8110_b54b256216a4
name: CHST4
is: Q8NCG5
is encoded by: hsa:10164
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_6a43bdfc_5bd0_468d_b190_93b426431d35
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:7108
is: O76062
initial concentration: NaN
name: TM7SF2
constant: false
initial amount: NaN

metaR N2M2NMASNtly
reactant: MODEL1310110041#
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110041#
reversible: false
name: n2m2nmasn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR r0779
modifier: MODEL1310110041#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110041#

metaR DHEAtr
reversible: true
name: Dehydroepiandrosterone transport
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is: SBO:0000185

metaM ser D e
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false
name: D-serine
initial concentration: 1.0
is: CHEBI:16523
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

metaM CE2422 m
initial amount: NaN
is: HMDB11123
boundary condition: false
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28387
initial concentration: 1.0

metaR r0437
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110041#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110041#
reactant: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13

metaM clpn hs c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
is: CHEBI:28494
type: Species
is: SBO:0000247
initial concentration: 1.0
name: cardiolipin

http://identifiers.org/biomodels.db/MODEL1310110041#_a1dd085d_625f_4839_8e5e_c888e42c4bdb
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GLB1
initial amount: NaN
is encoded by: hsa:2720
is: P16278
type: Species

metaR r0377
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110041#
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000000
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
modifier: MODEL1310110041#
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_721ab81b_8eb0_42cf_8139_ada045302e1f
is: O15244
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6582
name: SLC22A2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR r2320
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110041#
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#

metaR r0885
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reactant: MODEL1310110041#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
product: MODEL1310110041#
kinetic law: MODEL1310110041#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110041#

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16240
has only substance units: false
type: Species
is: C00027
name: Hydrogen peroxide
initial concentration: 1.0
is: HMDB03125

metaM aicar e
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58475
is: HMDB01517
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_ae86e46c_9e25_45ef_ac58_8a8caff5a662
initial concentration: NaN
name: DUOX1
is encoded by: hsa:53905
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q9NRD9
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_f9ccd8a7_9a03_43a1_84cc_eb3666e9f7b6
is encoded by: hsa:63917
type: Species
is: SBO:0000252
constant: false
is: B3KWF4
initial amount: NaN
has only substance units: false
name: GALNT11
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_76c2c904_43cf_4a19_840c_4a23e831cbcc
type: Species
boundary condition: true
name: INPP5B
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: P32019
initial amount: NaN
is encoded by: hsa:3633

http://identifiers.org/biomodels.db/MODEL1310110041#_5eb4482e_ce22_4a30_abdf_64efb1cf25f9
is: P20933
type: Species
is encoded by: hsa:175
is: SBO:0000252
name: AGA
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_08c5264e_87f0_4c9e_b125_951a94877b1c
boundary condition: true
initial concentration: NaN
type: Species
name: SLC7A2
constant: false
is: SBO:0000252
is: P52569
has only substance units: false
is encoded by: hsa:6542
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_035a2f53_2d41_4616_b8c9_4879d704db22
type: Species
is: SBO:0000252
is encoded by: hsa:AW277253
has only substance units: false
initial concentration: NaN
name: _AW277253_1_c
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_bf23f589_d092_491d_bffd_a16b906475ef
type: Species
has only substance units: false
is encoded by: hsa:6888
constant: false
initial amount: NaN
initial concentration: NaN
name: TALDO1
is: SBO:0000252
boundary condition: true
is: P37837

http://identifiers.org/biomodels.db/MODEL1310110041#_ec8553e8_7c65_47fd_8431_e1fdd119f5b5
is: SBO:0000252
name: SLC22A3
is encoded by: hsa:6581
has only substance units: false
type: Species
is: Q5SYN6
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_e4c1e223_0ef9_4121_ba87_2ec10ffa77d7
name: HEXA
constant: false
is: SBO:0000252
is: P06865
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3073
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_bde7ac29_f8f4_4bbe_bd27_db683337f97c
is: Q9P2X0
constant: false
is: SBO:0000252
name: DPM3
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:54344
initial concentration: NaN

metaR APOCFm
reactant: MODEL1310110041#
name: Apocarboxylase formation, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110041#
is: SBO:0000176
product: MODEL1310110041#

metaR FACOAL204
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
product: MODEL1310110041#
modifier: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269
type: Reaction
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
fast: false

metaR HMGCOASim
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
reactant: MODEL1310110041#
product: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
type: Reaction

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110041#
type: Reaction
reversible: true
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110041#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
product: MODEL1310110041#
fast: false

metaR FACOAL80i
kinetic law: MODEL1310110041#
type: Reaction
name: fatty-acid--CoA ligase (octanoate)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269

metaR Q10H2e
reversible: true
fast: false
name: transport of ubiquinol into lymph
product: MODEL1310110041#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
kinetic law: MODEL1310110041#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110041#

metaM 3aib D e
name: D-3-Amino-isobutanoate
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB02299
initial amount: NaN
is: SBO:0000247

metaR r2321
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110041#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
is: SBO:0000185

metaR NACHEXA10ly
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110041#
modifier: MODEL1310110041#
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_baf5fd9c_15a9_40bf_b1ed_a4e0b9e6e071
name: NDUFV1
is: E5KNH5
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4723
boundary condition: true

metaM ksi deg21 l
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
name: keratan sulfate I, degradation product 21
initial concentration: 1.0
is: SBO:0000247

metaM core6 g
initial amount: NaN
name: Core 6
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16478
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaM ser D c
is: HMDB03406
boundary condition: false
is: CHEBI:16523
constant: false
has only substance units: false
name: D-serine
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN

metaM HC00229 e
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:28189
constant: false
name: Isomaltose
has only substance units: false

metaR FUT16g
modifier: MODEL1310110041#
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.69
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
product: MODEL1310110041#

metaM 6thf e
name: hexaglutamyl folate (THF)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/169691

metaM 4ppcys c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
constant: false
is: HMDB01117
is: SBO:0000247
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
is: CHEBI:59458
has only substance units: false
type: Species
boundary condition: false

metaR RE1530C
product: MODEL1310110041#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
name: RE1530
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000

metaM HC02214 e
constant: false
boundary condition: false
initial concentration: 1.0
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
type: Species
is: CHEBI:28852
initial amount: NaN
has only substance units: false

metaM lnlncg r
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
name: gamma-linolenate
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB03073
is: CHEBI:32391

metaR r0226
reactant: MODEL1310110041#
is: SBO:0000176
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
fast: false
modifier: MODEL1310110041#
reversible: false
product: MODEL1310110041#
type: Reaction
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:

metaR O2t
name: o2 transport (diffusion)
type: Reaction
product: MODEL1310110041#
kinetic law: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110041#_c0802894_77cc_4216_8f62_cffa81e850e3
boundary condition: true
name: CHST3
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:9469
is: Q7LGC8
initial concentration: NaN
initial amount: NaN

metaM nh4 m
name: Ammonium
initial amount: NaN
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: C01342
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:28938
is: HMDB00051

metaM aicar c
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: CHEBI:58475
is: SBO:0000247
is: HMDB01517

http://identifiers.org/biomodels.db/MODEL1310110041#_5702cfc2_a1f0_4488_8487_91790edb517b
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC24A3
type: Species
boundary condition: true
constant: false
is: Q9HC58
initial amount: NaN
is encoded by: hsa:57419

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: C01328
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01039
constant: false
name: hydroxide ion
initial concentration: 1.0
boundary condition: false

metaM m8mpdol U r
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:59093
boundary condition: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
initial concentration: 1.0

metaR r2322
is: SBO:0000185
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_b16e6165_743a_41b0_b812_bbc83874ee15
is encoded by: hsa:5092
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PCBD1
is: P61457
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR CITtam
name: citrate transport, mitochondrial
product: MODEL1310110041#
is described by: ECO:0000269
modifier: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110041#
is: SBO:0000185
reversible: true
reactant: MODEL1310110041#
type: Reaction

metaR 3SPYRSP
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
is described by: ECO:0000000
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_81138346_bb09_4184_9bd2_5b2e63f88561
type: Species
name: PRDX1
initial amount: NaN
is encoded by: hsa:5052
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM pheacgln e
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
is: HMDB06344
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:58310
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_06e6bc14_1978_415a_bba4_716116999be6
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: DPAGT1
is encoded by: hsa:1798
initial amount: NaN
initial concentration: NaN
type: Species

metaR THP2Ctp
is described by: ECO:0000000
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_2817599d_5a0f_4824_9cdd_d143b584fc02
constant: false
is: P16066
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4881
name: NPR1

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_27815009_bc3e_4eaf_bbe4_7727e2511b9c
has only substance units: false
constant: false
name: PPCDC
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:60490
type: Species
initial concentration: NaN
is: Q96CD2

metaR CORE2GTg
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
fast: false
type: Reaction
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_ee4ad100_57e4_4fa2_83d6_ae6a063d2ae9
is: SBO:0000252
name: ALG2
initial amount: NaN
is encoded by: hsa:85365
boundary condition: true
type: Species
is: Q9H553
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_efd20f0a_ff2a_49e3_8698_96fb53e61cd9
boundary condition: true
is: Q99798
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:50
name: ACO2
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_3c46333b_5953_48a4_9af3_0007ab74a2ce
is: SBO:0000252
has only substance units: false
constant: false
name: AMY2B
initial amount: NaN
boundary condition: true
is: P19961
is encoded by: hsa:280
type: Species
initial concentration: NaN

metaM e4hglu m
constant: false
is: HMDB02273
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:6331
name: erythro-4-hydroxy-L-glutamate(1-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8aef5b2e_5f9e_4982_8c3a_d7587545a2c3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: DGKZ
constant: false
is: G3V0F6
initial amount: NaN
is encoded by: hsa:8525
boundary condition: true
type: Species

metaR r1681
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110041#
reversible: false
type: Reaction
fast: false

metaR r2323
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110041#
reversible: true
reactant: MODEL1310110041#
type: Reaction

metaM amet r
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
is: HMDB01185
name: S-adenosyl-L-methionine
is: CHEBI:15414
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_9b5c660d_208c_47b6_a71f_e56c8bb70f2e
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2653
name: GCSH
is: P23434
constant: false
type: Species

metaM glyc R m
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species
is: CHEBI:16659
has only substance units: false
boundary condition: false
name: D-glycerate
initial concentration: 1.0
is: HMDB00139
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_c00a1da7_e77f_4132_8826_9e0fe8a3c82a
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: GLUD1
initial amount: NaN
is encoded by: hsa:2746
boundary condition: true
is: E9KL48
is: SBO:0000252

metaR GMPtg
is described by: ECO:0000269
product: MODEL1310110041#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
reversible: true
name: GMP transport (Golgi)

http://identifiers.org/biomodels.db/MODEL1310110041#_2eb12d79_f3fb_4f56_ba7d_ab0ad3511942
is: Q14032
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:570
type: Species
name: BAAT

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
initial amount: NaN
is: CHEBI:18287
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00174
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1

metaR D 3AIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: D-3-amino-isobutyrate transport
kinetic law: MODEL1310110041#

metaR RE1573M
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE1573
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
modifier: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110041#

metaM HC02214 c
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:28852

http://identifiers.org/biomodels.db/MODEL1310110041#_387265bd_a123_471e_a9f0_dfe9e99b1306
is encoded by: hsa:483
has only substance units: false
constant: false
boundary condition: true
name: ATP1B3
is: P54709
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110041#_1e91778c_3e79_48fa_a1f4_8239b1b39231
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152
name: PDE9A
constant: false
initial concentration: NaN

metaR GALASE13ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110041#
type: Reaction
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110041#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_90820e87_336b_4f93_9d87_b436e3964153
boundary condition: true
is: SBO:0000252
constant: false
name: ALDH7A1
is: E7EPT3
is encoded by: hsa:501
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_8b49dadb_1a20_46de_9ea8_4484f56f34ee
type: Species
initial concentration: NaN
is: Q546Y9
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57379
constant: false
name: AICDA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110041#_d2b56845_b549_4de5_bd63_2be89b4fd2e1
initial concentration: NaN
is encoded by: hsa:4725
boundary condition: true
initial amount: NaN
is: Q6IBA0
is: SBO:0000252
constant: false
name: NDUFS5
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110041#_a788a27e_08d3_4786_8b63_6ce440fca70c
initial amount: NaN
type: Species
is encoded by: hsa:LOC727762
has only substance units: false
constant: false
boundary condition: true
name: _LOC727762_1_m
initial concentration: NaN
is: SBO:0000252

metaR LPS2e
product: MODEL1310110041#
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
modifier: MODEL1310110041#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110041#
name: lipase, extracellular
fast: false
is: SBO:0000176

metaM galgalthcrm hs g
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0
constant: false
name: Gal-Gal-Gal-Gal-Glc-Cer
is: CHEBI:26174
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaM pe hs m
is: CHEBI:16038
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110041#_8d8bf537_223e_425f_a7cd_53dedd7c477f
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: _AI378339_1_m
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AI378339

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Core 6

metaM leu L m
constant: false
type: Species
boundary condition: false
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15603
has only substance units: false
is: SBO:0000247
is: HMDB00687

metaR CHSTEROLt1
name: cholesterol intracellular transport
type: Reaction
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000185
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
modifier: MODEL1310110041#

metaR BHBt
product: MODEL1310110041#
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110041#
type: Reaction

metaR GLYOX
kinetic law: MODEL1310110041#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.6
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
modifier: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000269
name: hydroxyacylglutathione hydrolase

metaR DHFtl
is: SBO:0000185
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
fast: false
kinetic law: MODEL1310110041#
reversible: true
name: dihydrofolate reversible lysosomal transport
product: MODEL1310110041#

metaR r2324
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction

metaM pail4p hs n
is: CHEBI:58178
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
initial concentration: 1.0

metaR r0908
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
kinetic law: MODEL1310110041#
name: Postulated transport reaction
reversible: true
product: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110041#
fast: false

metaM oh1 c
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
is: C01328
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: hydroxide ion
is: HMDB01039
constant: false
type: Species

metaR r2079
type: Reaction
reactant: MODEL1310110041#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
is described by: ECO:0000000
modifier: MODEL1310110041#

metaR PRO Dtde
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
reversible: true
name: D-proline transport, extracellular
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_cf0599c9_b9cb_4bce_9b10_8ce1108a91e9
name: COX3
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4514
is: SBO:0000252
initial concentration: NaN
is: P00414
type: Species

metaR BPNT
is described by: ECO:0000269
kinetic law: MODEL1310110041#
product: MODEL1310110041#
modifier: MODEL1310110041#
fast: false
reactant: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.1.3.7
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
name: 3',5'-bisphosphate nucleotidase

metaR ALAyLATthc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR CYSPHELAT2tc
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM atp x
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00538
type: Species
is: CHEBI:57299
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00002
name: ATP(4-)

metaM pheacgln c
is: SBO:0000247
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
is: CHEBI:58310
has only substance units: false
type: Species
is: HMDB06344
boundary condition: false

metaR r1538
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
reversible: false
product: MODEL1310110041#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110041#
type: Reaction

metaR NADS2
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.1
kinetic law: MODEL1310110041#
name: NAD synthase (glutamine-hydrolysing)
modifier: MODEL1310110041#
fast: false
is: SBO:0000176
reactant: MODEL1310110041#
is described by: ECO:0000269
reversible: false
type: Reaction
product: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
is: HMDB00121
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
boundary condition: false
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110041#_387c4839_618d_4290_95bb_6c404aefc76f
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:240
name: ALOX5
initial amount: NaN
initial concentration: NaN
is: P09917
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_831efa9c_8fac_4c53_adfb_beb56270e2a2
is encoded by: hsa:5152
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: PDE9A
type: Species
is: SBO:0000252
initial concentration: NaN

metaM m2mpdol U c
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:28049
is: SBO:0000247
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
boundary condition: false
has only substance units: false

metaR CHSTEROLt2
name: cholesterol intracellular transport
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110041#

metaR MI13PP
name: inositol-1,3-bisphosphate 3-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110041#
reversible: false
fast: false
product: MODEL1310110041#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110041#

metaM 5adtststerone e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
is: HMDB02961
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
constant: false
has only substance units: false

metaR 34DHOXPEGt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
product: MODEL1310110041#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110041#
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
reactant: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_818be7e4_4ee7_4eaf_b102_10d484fdfbb6
has only substance units: false
is encoded by: hsa:6647
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: P00441
name: SOD1
initial amount: NaN
boundary condition: true

metaR r2325
reactant: MODEL1310110041#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110041#

metaR HMGLm
reactant: MODEL1310110041#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.3.4
fast: false
reversible: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
name: hydroxymethylglutaryl-CoA lyase
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
modifier: MODEL1310110041#

http://identifiers.org/biomodels.db/MODEL1310110041#_a54f24a3_bbec_48be_8e1d_504457505c57
name: PKM2
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5315
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: P14618

metaM xtsn c
has only substance units: false
is: CHEBI:18107
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false
is: SBO:0000247
initial amount: NaN
name: xanthosine
initial concentration: 1.0
is: HMDB00299
type: Species
boundary condition: false

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial amount: NaN
is: CHEBI:32984
constant: false
has only substance units: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_1bd72851_ebf8_414a_8342_1f95e0232b52
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4967
boundary condition: true
initial concentration: NaN
name: OGDH
constant: false
is: Q02218

metaR DNDPt37m
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
modifier: MODEL1310110041#
is described by: ECO:0000269
is: SBO:0000185
reversible: false
product: MODEL1310110041#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUTP transport via dTDP antiport

metaR CHSTEROLt3
is described by: ECO:0000000
type: Reaction
name: cholesterol intracellular transport
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
kinetic law: MODEL1310110041#
product: MODEL1310110041#
fast: false
reversible: true

metaR FUCASEe
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
is version of: http://identifiers.org/ec-code/3.2.1.51
product: MODEL1310110041#
type: Reaction
reactant: MODEL1310110041#
reversible: false
is described by: ECO:0000000
fast: false
name: alpha-fucosidase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110041#_6a29f149_8d23_44f8_9574_6faec36ec404
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9990
is: Q9UHW9
name: SLC12A6
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r2326
reversible: true
reactant: MODEL1310110041#
kinetic law: MODEL1310110041#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_c2ddddcd_9c79_45e7_91be_f7e999f8f9f2
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3162
initial amount: NaN
is: SBO:0000252
name: HMOX1
is: Q6FH11
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110041#_ccafab6f_b051_4e79_aa71_89e84533a255
boundary condition: true
is: E7EPT3
is: SBO:0000252
type: Species
name: ALDH7A1
is encoded by: hsa:501
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM CE2838 e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
has only substance units: false
constant: false
name: maltononaose
type: Species
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110041#_972e75a7_45d5_49a4_b6f2_eaaa874371e6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51079
has only substance units: false
name: NDUFA13
type: Species
is: Q9P0J0
is: SBO:0000252
constant: false
boundary condition: true

metaR AG13T7g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110041#
modifier: MODEL1310110041#
reversible: false
reactant: MODEL1310110041#
product: MODEL1310110041#
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r1685
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
product: MODEL1310110041#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110041#
reactant: MODEL1310110041#

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110041#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110041#
type: Reaction
modifier: MODEL1310110041#
reversible: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
kinetic law: MODEL1310110041#
name: ubiquinol-6 cytochrome c reductase, Complex III
is: SBO:0000185
fast: false

metaR r0666
reversible: true
reactant: MODEL1310110041#
is described by: ECO:0000000
is: SBO:0000176
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
product: MODEL1310110041#
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
modifier: MODEL1310110041#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
fast: false
is: SBO:0000185
name: blood group intracellular transport
type: Reaction
reversible: true

metaR GBA
fast: false
kinetic law: MODEL1310110041#
product: MODEL1310110041#
is: SBO:0000176
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
name: Glucosylceramidase
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110041#
type: Reaction

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR r0002
product: MODEL1310110041#
reactant: MODEL1310110041#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reversible: true
kinetic law: MODEL1310110041#
name: Active transport

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_26911ddd_6168_47a0_bb39_3a031f204c10
is: SBO:0000252
constant: false
is encoded by: hsa:51166
boundary condition: true
type: Species
initial concentration: NaN
name: AADAT
has only substance units: false
initial amount: NaN
is: Q4W5N8

metaR HISCAT1
kinetic law: MODEL1310110041#
product: MODEL1310110041#
reactant: MODEL1310110041#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_69fb0672_3be0_41d3_8eb6_9d134c641c62
initial amount: NaN
has only substance units: false
name: MAN2A1
is: Q16706
is encoded by: hsa:4124
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
boundary condition: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: CHEBI:18287
is: HMDB00174
constant: false

http://identifiers.org/biomodels.db/MODEL1310110041#_72a755c4_8dde_41d9_9b79_1c14b028d411
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:10935
initial concentration: NaN
has only substance units: false
is: P30048
is: SBO:0000252
name: PRDX3

http://identifiers.org/biomodels.db/MODEL1310110041#_71de4f45_f0ac_42c0_8ace_106e5b91ae46
type: Species
is: Q9Y2C5
constant: false
has only substance units: false
name: SLC17A4
initial concentration: NaN
is encoded by: hsa:10050
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR RE3001M
fast: false
modifier: MODEL1310110041#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.34
type: Reaction
reactant: MODEL1310110041#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110041#
product: MODEL1310110041#
name: RE3001

http://identifiers.org/biomodels.db/MODEL1310110041#_e8b5ea92_e7bc_418b_822b_e800d7ac2dbf
boundary condition: true
is: SBO:0000252
is: P54750
constant: false
is encoded by: hsa:5136
type: Species
name: PDE1A
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110041#_16410c72_c083_4033_bb48_879258c27de6
boundary condition: true
constant: false
is encoded by: hsa:3038
is: SBO:0000252
is: Q96RV2
initial concentration: NaN
name: HAS3
initial amount: NaN
has only substance units: false
type: Species

metaR r2327
kinetic law: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110041#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110041#
type: Reaction

metaM CE2247 c
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 3-hydroxyeicosanoyl-CoA
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h27-30,34-36,40,49,52-53H,4-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/t29?,30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: CE2247
initial amount: NaN
is: CHEBI:52324

metaM 5adtststerone c
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: CHEBI:16330
is: HMDB02961
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110041#
reactant: MODEL1310110041#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110041#_60df9bb6_a643_4994_9bf1_98a25aefde07
has only substance units: false
boundary condition: true
is encoded by: hsa:10195
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: ALG3
is: SBO:0000252

metaR DHFtm
type: Reaction
product: MODEL1310110041#
is described by: ECO:0000000
kinetic law: MODEL1310110041#
is: SBO:0000185
name: dihydrofolate reversible mitochondrial transport
reactant: MODEL1310110041#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false