metaM h g
type: Species
is: SBO:0000247
is: CHEBI:24636
name: proton
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_e458020c_5983_46e4_8b22_b49b20a3bd3e
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: ATP5G1
is encoded by: hsa:516
is: SBO:0000252
is: P05496
constant: false
initial concentration: NaN

metaM anth e
constant: false
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: SBO:0000247
initial amount: NaN
name: anthranilate
is: HMDB01123
type: Species
is: CHEBI:16567
initial concentration: 1.0
boundary condition: false

metaM 3octdece1coa m
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06294
name: 3-hydroxyoctadecenoylcoa
boundary condition: false
initial amount: NaN
type: Species

metaM udpgal g
is: HMDB00302
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
name: UDP-D-galactose(2-)
is: CHEBI:58439
boundary condition: false

metaR TMNDNCCPT1
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110040#
type: Reaction
name: carnitine O-palmitoyltransferase
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false

metaR r0181
kinetic law: MODEL1310110040#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
modifier: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110040#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR SCP21x
kinetic law: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
fast: false
name: Sterol carrier protein 2
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
product: MODEL1310110040#

metaR GLUt6
is: SBO:0000185
product: MODEL1310110040#
reversible: false
fast: false
modifier: MODEL1310110040#
is described by: ECO:0000269
name: Glutamate transport via Na, H symport and K antiport
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
type: Reaction
reactant: MODEL1310110040#

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR M16NTg
reversible: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.143
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_98b6c060_bc87_4fdc_b652_7832d865cac3
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PLA2G2F
type: Species
is: Q9BZM2
is encoded by: hsa:64600
has only substance units: false
is: SBO:0000252

metaM ksi deg40 l
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C40H68N2O31 CHARGE: 0
boundary condition: false
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 40
has only substance units: false

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_27bd4f98_3f24_497a_b525_d689bb4ddf41
name: _R14373_1_x
is encoded by: hsa:R14373
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_ea793cdf_00ae_46e3_b974_19c39d280e52
is: SBO:0000252
is encoded by: hsa:AA203143
type: Species
constant: false
name: _AA203143_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR PHCHGSm
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_1fff80dd_92c8_414d_8459_8c59fb870942
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SLC13A5
is: Q86YT5
boundary condition: true
is encoded by: hsa:284111
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2e05aea0_1252_4b9b_acf8_914ff396ef95
is encoded by: hsa:4535
name: ND1
initial concentration: NaN
constant: false
is: Q85KV6
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM h e
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: C00080
name: proton
is: SBO:0000247
has only substance units: false
is: CHEBI:24636
boundary condition: false
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
initial amount: NaN

metaR UAGALDP
kinetic law: MODEL1310110040#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110040#
name: UDP-N-acetylgalactosamine diphosphorylase
product: MODEL1310110040#
is described by: ECO:0000000

metaM btcoa m
initial amount: NaN
is: HMDB01088
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: C00136
is: CHEBI:57371
name: Butanoyl-CoA

metaR r0385
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
product: MODEL1310110040#
reversible: false
fast: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
type: Reaction

metaM anth c
constant: false
is: SBO:0000247
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01123
is: CHEBI:16567
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_6cbb8128_37d3_4c99_bd0c_68a54ae19089
is encoded by: hsa:6392
is encoded by: hsa:6389
is encoded by: hsa:6390
is: SBO:0000297
has only substance units: false
boundary condition: true
has part: P31040
is encoded by: hsa:6391
initial amount: NaN
name: SDHA:SDHB:SDHC:SDHD
has part: O14521
initial concentration: NaN
has part: Q99643
type: Species
constant: false
has part: P21912

metaR UPPN
reversible: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
name: b-ureidopropionase
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110040#

metaM CE2421 m
is: HMDB02329
initial concentration: 1.0
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:30623
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_986a37b5_666a_4897_9fdc_15f14ab0371d
has part: P23921
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: RRM1:RRM2
constant: false
is: SBO:0000297
has part: P31350
is encoded by: hsa:6241
has only substance units: false
is encoded by: hsa:6240

metaM nicrnt c
initial amount: NaN
initial concentration: 1.0
is: HMDB01132
type: Species
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
constant: false
boundary condition: false
name: Nicotinate D-ribonucleotide
has only substance units: false
is: SBO:0000247
is: CHEBI:57502

http://identifiers.org/biomodels.db/MODEL1310110040#_bd9305da_50d7_4c44_b62d_f7e857e988e9
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:6120
name: RPE
initial concentration: NaN
type: Species
is: Q96AT9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_842e8265_dac8_4068_9481_75010edb9856
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI222095
constant: false
name: _AI222095_1_e
is: SBO:0000252
initial amount: NaN

metaR EX tdcrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_8c2ed45f_8a79_4bd8_be07_e5483d966c7f
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: E9KL48
has only substance units: false
name: GLUD1
is encoded by: hsa:2746
type: Species
initial amount: NaN

metaM uacgam c
initial concentration: 1.0
has only substance units: false
is: HMDB00290
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR PFK26
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
name: 6-phosphofructo-2-kinase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.105
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_fa2e60c2_5fac_4f47_aae9_04e964b406a0
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC29A1
boundary condition: true
has only substance units: false
is: Q99808
is: SBO:0000252
is encoded by: hsa:2030

metaM 13 cis retn r
is: HMDB06219
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
boundary condition: false
name: 13-cis-retinoate
initial concentration: 1.0
is: D00348
has only substance units: false

metaM cit m
is: C00158
is: CHEBI:16947
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
initial concentration: 1.0
is: HMDB00094
is: SBO:0000247
type: Species
name: Citrate
constant: false
has only substance units: false

metaM odecoa c
is: HMDB01322
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:3793
initial amount: NaN

metaR r1020
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000185
product: MODEL1310110040#
reversible: true
fast: false
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR r0504
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
is: SBO:0000176
reversible: true

metaR FATP5t
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110040#
is described by: ECO:0000269
name: fatty acid electroneutral transport
is: SBO:0000185
fast: false
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_37bc525b_15dd_4a58_b2ad_436e494d52c7
initial concentration: NaN
name: ALDH3A2
is: P51648
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:224
type: Species
is: SBO:0000252

metaR 5MTHFt
type: Reaction
reversible: true
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_bc825e56_fcec_471a_b66c_40cf57ae829c
boundary condition: true
has only substance units: false
name: SLC3A2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: P08195
is encoded by: hsa:6520
initial concentration: NaN

metaM 3odcoa m
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial amount: NaN
is: HMDB03939
name: 3-Oxodecanoyl-CoA
is: SBO:0000247
is: CHEBI:28528
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0aa3a675_934e_4679_a41a_1c70365ce358
has only substance units: false
initial concentration: NaN
name: PANK3
is encoded by: hsa:79646
is: SBO:0000252
is: Q9H999
type: Species
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_36961a0a_b99a_4e7b_99b0_8077e4092a52
is encoded by: hsa:4846
initial amount: NaN
name: NOS3
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: A0S0A7
has only substance units: false

metaM h c
type: Species
initial amount: NaN
constant: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
is: C00080
name: proton
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8d4b2abc_32fe_444b_9ad3_626dffe30fe2
is: SBO:0000252
name: GGT7
is encoded by: hsa:2686
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: A0PJJ9
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_579157ed_a81f_481e_b42c_76827badbd72
type: Species
name: PLCXD2
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q0VAA5
constant: false
is encoded by: hsa:257068
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_4fb37d60_bad1_4f2b_b8a5_33cda3aff801
is encoded by: hsa:501
is: SBO:0000252
boundary condition: true
name: ALDH7A1
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: E7EPT3
constant: false

MODEL1310110040
reaction: metaR r1654
species: metaM dgdp m
reaction: metaR r0656
reaction: metaR r0839
species: metaM HC01522 c
species: metaM cyan e
reaction: metaR GACPAILter
reaction: metaR EX hdcea LPAREN e RPAREN
reaction: metaR ELAIDCRNt
reaction: metaR VALTAm
species: metaM HC01408 m
species: metaM cspg e l
species: metaM 5dhf m
reaction: metaR OCTDECCPT1
species: metaM uri c
reaction: metaR RAHY
reaction: metaR EX 5thf LPAREN e RPAREN
reaction: metaR DM hretn n
species: metaM pail hs n
reaction: metaR r0871
length unit: length
reaction: metaR r0603
reaction: metaR r2126
reaction: metaR EX fru LPAREN e RPAREN
reaction: metaR ICDHyrm
species: metaM 2oxoadp c
species: metaM 3ivcoa c
reaction: metaR r2387
species: metaM tststerone c
reaction: metaR DNDPt34m
reaction: metaR S6T7g
species: metaM 4pyrdx e
species: metaM ump r
reaction: metaR r0921
reaction: metaR MALSO4tm
reaction: metaR EX glc LPAREN e RPAREN
reaction: metaR GALK
reaction: metaR r0813
species: metaM 3ohdcoa m
reaction: metaR r0399
species: metaM cytd e
reaction: metaR r1443
reaction: metaR CYTK13n
reaction: metaR r0714
species: metaM xu5p D c
reaction: metaR ABTD
species: metaM hcys L c
species: metaM lgnc c
reaction: metaR OLEICFATPtc
reaction: metaR EX fol LPAREN e RPAREN
reaction: metaR HIBDm
reaction: metaR DUDPtn
species: metaM dhf e
reaction: metaR PPCDC
reaction: metaR r2129
species: metaM for r
species: metaM ksi deg25 l
species: metaM s7p c
reaction: metaR GLCAASE4ly
reaction: metaR q10tm
reaction: metaR r0975
species: metaM hpdcacrn m
reaction: metaR r1401
species: metaM xoltri25 c
reaction: metaR CTPtn
reaction: metaR r1548
reaction: metaR DITPtn
reaction: metaR MMTSADm
species: metaM oaa c
reaction: metaR EHGLAT2m
species: metaM pmtcrn x
reaction: metaR RE2814M
reaction: metaR GLYPROPRO1c
reaction: metaR LACZe
species: metaM dgtp m
reaction: metaR 5ADTSTSTERONESte
species: metaM glc D c
species: metaM pap c
species: metaM hexdiac c
species: metaM octdececoa c

metaM m5mpdol L r
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:37634
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20

metaM udpgal c
name: UDP-D-galactose(2-)
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
initial amount: NaN
is: CHEBI:58439
initial concentration: 1.0
is: HMDB00302
boundary condition: false

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM CE2432 m
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: SBO:0000247
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110040#_94a300f0_b423_486f_ad2a_4f4d2541a8c2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:84649
initial amount: NaN
is: Q96PD7
has only substance units: false
type: Species
constant: false
boundary condition: true
name: DGAT2

metaM ksi deg37 l
is: SBO:0000247
constant: false
is: CHEBI:57455
boundary condition: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 37
is: HMDB01354
initial concentration: 1.0

metaR 3HBCOAHLm
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_8901ee01_a9c9_4816_9f13_66885eef5027
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: SDHD
boundary condition: true
is: O14521
is encoded by: hsa:6392
constant: false
has only substance units: false

metaR RE2426C
name: RE2426
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#

metaR GGH 10FTHF6GLUe
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
product: MODEL1310110040#
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_1b80a5c5_0f76_4eb1_9475_3728e5a4b299
is encoded by: hsa:4731
is: SBO:0000297
initial amount: NaN
constant: false
has part: Q5VYT2
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has only substance units: false
type: Species
is encoded by: hsa:4712
boundary condition: true
initial concentration: NaN

metaR r0502
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is version of: http://identifiers.org/ec-code/2.7.1.113
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_987d4e35_032a_4d92_9fcb_a405a772590f
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:55163
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9NVS9
name: PNPO

http://identifiers.org/biomodels.db/MODEL1310110040#_f0ba1144_d321_4b5a_bcfd_361570b61a12
initial amount: NaN
is encoded by: hsa:517
constant: false
is: SBO:0000252
is: Q06055
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: ATP5G2

metaM gd1b hs g
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
is: CHEBI:28648
constant: false
name: GD1b
is: SBO:0000247
initial concentration: 1.0

metaM gtp n
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
has only substance units: false
is: CHEBI:37565
initial concentration: 1.0
boundary condition: false
constant: false
name: GTP(4-)
is: HMDB01273
initial amount: NaN
type: Species

metaR 4HGLSDm
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000212
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
reversible: true
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false

metaR r0381
fast: false
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_8e5752f8_73da_421b_9494_794501f017b2
initial amount: NaN
type: Species
has only substance units: false
name: ST8SIA1
is encoded by: hsa:6489
constant: false
boundary condition: true
is: SBO:0000252
is: Q92185
initial concentration: NaN

metaM lnlncgcrn c
boundary condition: false
constant: false
type: Species
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06318
initial amount: NaN
name: gamma-linolenyl carnitine

metaM fn2m2masn g
constant: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
initial amount: NaN
is: CHEBI:32984
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1

metaR r1758
reversible: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR DURIPP
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110040#
type: Reaction
reversible: true
name: deoxyuridine phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.3

http://identifiers.org/biomodels.db/MODEL1310110040#_d9c7f3e7_31ff_406f_9c85_be632a2684d6
constant: false
has only substance units: false
is: B4DY56
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:498
name: ATP5A1
initial concentration: NaN
boundary condition: true

metaR r1570
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110040#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM sphs1p r
is: HMDB00277
is: CHEBI:60119
initial amount: NaN
constant: false
name: sphingosine 1-phosphate(1-)
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_bf4600ec_8991_4bdb_be19_d45a0fcfb855
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: PDE9A
initial concentration: NaN
type: Species
is encoded by: hsa:5152
initial amount: NaN

metaR FAOXC1811601m
product: MODEL1310110040#
fast: false
name: Beta oxidation fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaM gtp m
name: GTP
boundary condition: false
constant: false
is: HMDB01273
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:37565

metaR DM anth
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_45bfe839_c119_4b61_9d41_fadb3eb9ec03
is: P16219
is encoded by: hsa:35
name: ACADS
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_15ffc11d_1d8d_4cbf_8bc9_ce2b9aa516ba
boundary condition: true
type: Species
is encoded by: hsa:5209
initial concentration: NaN
is: SBO:0000252
name: PFKFB3
constant: false
initial amount: NaN
has only substance units: false
is: Q16875

metaR ATPS4m
kinetic law: MODEL1310110040#
is: SBO:0000185
name: ATP synthase (four protons for one ATP)
modifier: MODEL1310110040#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
is version of: http://identifiers.org/ec-code/3.6.1.14
is version of: http://identifiers.org/ec-code/3.6.4.6
product: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.14
reactant: MODEL1310110040#
reversible: false

metaR r1571
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110040#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_eeacf521_ab1b_4c02_89a4_4bb10b012ce6
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: SLC26A6
has only substance units: false
is encoded by: hsa:65010
initial amount: NaN
constant: false
is: Q9Y3Y1

metaR BTND1
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
name: biotinidase (biotin)
type: Reaction
reversible: false

metaM 3ttetddcoa c
constant: false
type: Species
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02014

metaR DOLPMT4 Uer
fast: false
kinetic law: MODEL1310110040#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_9afac667_1682_4040_98b6_6397d322972f
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4831
is: P22392
has only substance units: false
name: NME2
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c2196176_a7a3_4f5c_8ee9_c1b2eecfca82
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27068
name: PPA2

http://identifiers.org/biomodels.db/MODEL1310110040#_6b7aa09b_8163_4cbe_b152_1b6096f134cd
is: SBO:0000252
is encoded by: hsa:4907
name: NT5E
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: P21589

http://identifiers.org/biomodels.db/MODEL1310110040#_2f40f76c_e240_4ac6_b245_b35662629713
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR r1467
reversible: true
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110040#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_0a0ee32d_6083_4112_b124_a0516b25d54b
type: Species
is encoded by: hsa:9963
initial concentration: NaN
is: Q9UHI7
constant: false
is: SBO:0000252
name: SLC23A1
has only substance units: false
initial amount: NaN
boundary condition: true

metaR NDPK10
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_c0d3e071_d18f_43a5_aafd_9ea83f827adb
name: PCBD1
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5092
boundary condition: true
initial amount: NaN

metaR CHOLt4
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000269
name: choline, sodium cotransport
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD

metaR DURAD
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
reversible: true
name: dihydrouracil dehydrogenase (NADP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
fast: false

metaR CYTK14n
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_c118e22c_4d2e_4245_a081_1cbe99922821
is: O76074
type: Species
name: PDE5A
boundary condition: true
is encoded by: hsa:8654
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR 24 25VITD2Hm
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1591.1) SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15358094,PMID:8266831 NOTES:based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.196 IT
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110040#
reversible: false
product: MODEL1310110040#
name: 24R-Vitamin D-25-hydroxylase (D2)
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.14.13.126

metaR RE1527M
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1527
reversible: true
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110040#

metaM ca2 e
boundary condition: false
initial amount: NaN
name: calcium(2+)
is: CHEBI:29108
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00464
initial concentration: 1.0
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_b85904bc_53ab_45f5_9d82_ab91a8f9f415
constant: false
has only substance units: false
boundary condition: true
is: O00217
name: NDUFS8
is encoded by: hsa:4728
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaM Tn antigen g
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
name: Tn antigen
boundary condition: false
is: C04383

metaM cit c
has only substance units: false
type: Species
is: HMDB00094
boundary condition: false
name: Citrate
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00158
initial amount: NaN
is: CHEBI:16947

metaM 3aib D m
boundary condition: false
initial concentration: 1.0
constant: false
name: D-3-Amino-isobutanoate
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
initial amount: NaN
is: C03265

metaR NACHEX18ly
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110040#
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110040#
modifier: MODEL1310110040#

metaM fum c
is: SBO:0000247
initial concentration: 1.0
is: C00122
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
name: Fumarate
constant: false
is: CHEBI:29806
initial amount: NaN
is: HMDB00134
boundary condition: false
type: Species

metaM leuktrC4 c
is: HMDB01198
initial concentration: 1.0
type: Species
name: leukotriene C4(2-)
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false

metaM acgam c
name: N-acetyl-D-glucosamine
is: HMDB00215
is: CHEBI:17411
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

metaM 3mox4hpac m
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
has only substance units: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
boundary condition: false
type: Species
is: HMDB05175
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:28111

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR ASPDTDe
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
name: D-aspartate transport, extracellular
type: Reaction
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110040#

metaR GALASE10ly
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
name: beta-galactosidase, lysosomal
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
product: MODEL1310110040#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reversible: false

metaM ca2 c
is: SBO:0000247
initial amount: NaN
is: CHEBI:29108
constant: false
boundary condition: false
type: Species
name: calcium(2+)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: HMDB00464

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR ENO
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.11
type: Reaction
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
name: enolase
product: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110040#
reversible: true

metaM 2mb2coa c
is: HMDB02054
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
type: Species
name: 2-methylcrotonoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN

metaR NICRNTtn
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
reversible: true
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
name: NICRNT transport, nuclear trhough pore
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_f5c1203f_9145_4053_b389_1754163139d2
is: SBO:0000252
name: GGT1
is encoded by: hsa:2678
initial concentration: NaN
boundary condition: true
constant: false
is: P19440
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_ef8cacb7_cc9b_449f_acef_ed27ba8e709c
initial concentration: NaN
is encoded by: hsa:514
initial amount: NaN
is encoded by: hsa:498
is encoded by: hsa:513
type: Species
has part: P30049
has part: P06576
is encoded by: hsa:509
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has part: P56381
has part: A8K092
is encoded by: hsa:506
has part: P36542
constant: false
has only substance units: false
boundary condition: true

metaM cit e
name: citrate(3-)
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
is: CHEBI:16947
type: Species
is: HMDB00094

http://identifiers.org/biomodels.db/MODEL1310110040#_0a07bde3_43bb_4a86_8a87_9f7190c1f214
boundary condition: true
is encoded by: hsa:9415
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: FADS2
is: O95864
constant: false
initial amount: NaN

metaR PI4PP
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
name: phosphatidylinositol-4-phosphate 4-phosphatase

metaM for r
initial amount: NaN
has only substance units: false
is: CHEBI:15740
constant: false
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
initial concentration: 1.0
is: C00058
is: SBO:0000247
boundary condition: false
type: Species

metaM CE2434 m
is: CHEBI:57795
initial amount: NaN
is: SBO:0000247
constant: false
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434

metaR RDH2
product: MODEL1310110040#
fast: false
name: retinol dehydrogenase (9-cis,NADH)
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110040#

metaR ENGASE3ly
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

metaM leuktrC4 e
has only substance units: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
is: CHEBI:57973
is: HMDB01198
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: leukotriene C4(2-)
is: SBO:0000247

metaR XYLt
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
name: D-xylose reversible transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_96bde326_2880_4044_a692_473f56af0209
name: SLC2A2
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6514
is: SBO:0000252
is: P11168
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_c9b75ca2_d7af_4745_a9d0_dc9faa6387c3
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: OCRL
initial amount: NaN
has only substance units: false
is encoded by: hsa:4952
is: Q01968
is: SBO:0000252

metaR HSAT4ly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_64b657df_18f0_415a_b795_8bf31a917b79
name: NDUFA8
initial concentration: NaN
is: B1AM93
is encoded by: hsa:4702
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_051da88b_a65f_47aa_9646_4b743c444b03
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5207
constant: false
name: PFKFB1
type: Species
is: P16118
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_94d3de8b_94a8_4a3a_94c4_851c8405446f
is encoded by: hsa:5335
is: Q9UFY1
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: PLCG1
is: SBO:0000252

metaR C8CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR GAL3ST11
is: SBO:0000176
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.11
fast: false
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: Galactosylceramide sulfotransferase
kinetic law: MODEL1310110040#
reversible: false
is described by: ECO:0000000
type: Reaction

metaM ksi pre8 g
constant: false
is: CHEBI:28067
has only substance units: false
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: keratan sulfate I biosynthesis, precursor 8

metaR C161OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaR 5OXPROt
is: SBO:0000185
name: Transport of 5-oxoprolinate
fast: false
kinetic law: MODEL1310110040#
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaR RDH3
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
name: retinol dehydrogenase (11-cis,NADH)
reversible: true
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_59ad8b1f_87ca_4a2c_8f5f_ea90955f10af
is: Q15111
name: PLCL1
boundary condition: true
is encoded by: hsa:5334
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR MI13PP
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
name: inositol-1,3-bisphosphate 3-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110040#_7dd7e859_2bab_475a_a002_cb40ac6bd51e
is: Q96T66
initial amount: NaN
is encoded by: hsa:349565
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: NMNAT3
is: SBO:0000252
type: Species

metaR PA HStn
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110040#
name: phosphatidate transport, nuclear
reversible: true
type: Reaction
is described by: ECO:0000000

metaM 3odcoa x
is: SBO:0000247
initial amount: NaN
is: CHEBI:28528
type: Species
initial concentration: 1.0
is: HMDB03939
name: 3-Oxodecanoyl-CoA
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
boundary condition: false
has only substance units: false

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_30e2048d_bb0a_4f85_8bec_88c3f4fedcc4
boundary condition: true
name: _AI971023_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI971023
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_f5c69cd1_5ece_4efc_851f_70f919796bae
name: UCK1
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:83549
is: Q5JT09
is: SBO:0000252
has only substance units: false

metaM hdca r
is: HMDB00220
is: C00249
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
is: SBO:0000247
is: CHEBI:7896
type: Species
constant: false
has only substance units: false
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0

metaM nh4 x
has only substance units: false
initial concentration: 1.0
is: CHEBI:28938
is: C01342
is: SBO:0000247
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
constant: false
type: Species
initial amount: NaN
name: Ammonium

metaR RE3628M
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3628
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110040#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_f1b6b331_b589_4327_a87f_c6525a00d4b5
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9UI40
name: SLC24A2
is encoded by: hsa:25769
has only substance units: false

metaR FRDPtcr
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reversible: true
is described by: ECO:0000134
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185

metaR LYStm
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true
name: Lysine mitochondrial transport via ornithine carrier
fast: false
product: MODEL1310110040#

metaM 3ttetddcoa m
is: SBO:0000247
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
type: Species
has only substance units: false
is: HMDB02014

metaM HC02179 c
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
initial amount: NaN
constant: false
name: 20-hydroxy-arachidonate
initial concentration: 1.0

metaR UMPK7n
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
name: UMP kinase (dGTP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_809b190e_4408_4154_badb_94e1cfc40d1f
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2645
initial amount: NaN
initial concentration: NaN
name: GCK

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false
is: CHEBI:58147
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00978

http://identifiers.org/biomodels.db/MODEL1310110040#_c779e41b_4bd3_4655_ac77_ba6f1be07f56
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaR HSD3A1r
reactant: MODEL1310110040#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110040#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_181bf590_f155_4eb3_9af6_e298f0a2ed49
initial amount: NaN
is encoded by: hsa:11182
is: Q9UGQ3
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: SLC2A6
initial concentration: NaN
has only substance units: false

metaR CERT2rt
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: ceramide transport protein
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000

metaR TMNDNCCPT2
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_93251eb0_30ba_462f_88f9_c6e26686cfef
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC26A1
is encoded by: hsa:10861
initial concentration: NaN

metaM HC01415 m
name: (2E)-Octenoyl-CoA
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:27537

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR FAOXC2031836m
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:3 -> c18:3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM ksii core4 pre4 g
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: HMDB00175
has only substance units: false
is: CHEBI:58053
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_184c8ba2_8541_4d71_9258_f8886dc3635e
constant: false
boundary condition: true
type: Species
is encoded by: hsa:54898
initial concentration: NaN
initial amount: NaN
is: Q9NXB9
has only substance units: false
is: SBO:0000252
name: ELOVL2

metaM hs deg9 l
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: CHEBI:18268
type: Species
is: HMDB06355
constant: false
boundary condition: false
name: heparan sulfate, degradation product 9
has only substance units: false
is: SBO:0000247

metaR r0186
reversible: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r1466
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110040#
name: EC:2.3.1.86
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110040#

metaM sphs1p c
has only substance units: false
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
constant: false
type: Species
is: CHEBI:60119

metaM HC02187 c
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: reverse-triiodthyronine
initial amount: NaN

metaM 5aop m
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17549
has only substance units: false
is: C00430
name: 5-Amino-4-oxopentanoate
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01149

http://identifiers.org/biomodels.db/MODEL1310110040#_26a4ea0d_da83_41a4_bb37_02bc71866774
initial concentration: NaN
boundary condition: true
name: SMPD3
initial amount: NaN
constant: false
has only substance units: false
is: Q9NY59
is: SBO:0000252
type: Species
is encoded by: hsa:55512

metaM pe hs m
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial amount: NaN
type: Species
is: CHEBI:16038
name: phosphatidylethanolamine
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_b456b659_6405_43ae_8ccf_3e1ae1a0e196
is: P05187
name: ALPP
initial concentration: NaN
is encoded by: hsa:250
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_475d191b_75cb_4684_9e18_718fb720ade7
boundary condition: true
is encoded by: hsa:441024
name: MTHFD2L
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9H903
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_01afa936_aa96_42f4_a3e7_e7303b040e81
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI653169_1_c
is encoded by: hsa:AI653169
type: Species
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b9afa790_80ff_468c_8259_8f2f4cd2d699
constant: false
has only substance units: false
is: P43353
initial concentration: NaN
name: ALDH3B1
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:221

metaM tag hs e
name: triglyceride
is: CHEBI:17855
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
boundary condition: false
type: Species

metaM udpacgal l
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
is: HMDB00304
is: CHEBI:57847

metaR r1685
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reversible: true
product: MODEL1310110040#
is described by: ECO:0000000
name: Gamma-glutamyltransferase
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM 4mzym int2 r
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
name: 4-Methylzymosterol intermediate 2
initial amount: NaN
is: HMDB06838
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_959ef58f_41dc_4f36_9976_52113d82826e
boundary condition: true
is: SBO:0000252
type: Species
is: P05166
initial amount: NaN
name: PCCB
is encoded by: hsa:5096
constant: false
has only substance units: false
initial concentration: NaN

metaM 3hdeccoa c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
constant: false
type: Species
initial amount: NaN
name: 3-hydroxyhexadecenoylcoa
has only substance units: false
boundary condition: false
is: HMDB02014

metaM memgacpail hs r
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15809
is: SBO:0000247
has only substance units: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)

metaM dtdp c
is: C00363
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58369
boundary condition: false
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial amount: NaN

metaM maltpt e
type: Species
is: http://identifiers.org/pubchem.compound/5141
initial amount: NaN
is: HMDB01296
name: maltopentaose
constant: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: SBO:0000247
is: C02052
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR FAEL183
reactant: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
product: MODEL1310110040#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)

metaR C142CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_544462bb_a920_498e_8565_bb1fec19cef1
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CRAT
constant: false
is encoded by: hsa:1384
has only substance units: false

metaM urate e
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: Urate
is: CHEBI:17775
initial concentration: 1.0
boundary condition: false
is: HMDB00289
is: C00366
is: SBO:0000247

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57328
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
is: SBO:0000247
is: HMDB01373

metaM ksii core2 pre1 g
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: keratan sulfate II biosynthesis, precursor 1
is: CHEBI:28067
notes: FORMULA: C33H53N3O23X CHARGE: -1
initial concentration: 1.0

metaR MAN1PT2
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
is described by: ECO:0000000
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
name: mannose-1-phosphate guanylyltransferase (GDP)
is version of: http://identifiers.org/ec-code/2.7.7.13
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2a429d6f_92fc_476e_88bb_b13d9eab76fa
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: LDHD
constant: false
initial amount: NaN
is encoded by: hsa:197257

metaM HC02187 e
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
name: reverse-triiodthyronine

metaM i e
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
constant: false
initial concentration: 1.0
is: HMDB12238
type: Species
has only substance units: false
is: CHEBI:16382
name: iodide

metaR P5CDm
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3251e0b8_d9ba_4574_89e6_e0c985cea9a2
is encoded by: hsa:206
boundary condition: true
name: _206_1_c
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR AG13T14g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false

metaM acgam l
has only substance units: false
is: CHEBI:17411
name: N-acetyl-D-glucosamine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00215
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species

metaR EX 3hdececrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a3aa8a8a_9526_43eb_84bd_e6c918c555c9
name: PEMT
initial concentration: NaN
is encoded by: hsa:10400
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR URATEt
product: MODEL1310110040#
fast: false
type: Reaction
reversible: false
name: urate export from cytosol
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM abt c
boundary condition: false
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:18403
is: SBO:0000247
constant: false
is: HMDB01851
name: L-arabinitol

http://identifiers.org/biomodels.db/MODEL1310110040#_51b0cdb6_0efd_4d6a_a066_0b518056ecf1
is: SBO:0000252
boundary condition: true
is: A0PJM6
is encoded by: hsa:1120
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: CHKB
initial concentration: NaN

metaM sphs1p e
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:60119
is: HMDB00277
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
constant: false

metaM tag hs c
is: CHEBI:17855
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
type: Species
name: triglyceride

http://identifiers.org/biomodels.db/MODEL1310110040#_62c4bf9b_6ac8_476b_a329_5cc6f8a59aee
has only substance units: false
name: PPCS
is: Q9HAB8
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:79717

http://identifiers.org/biomodels.db/MODEL1310110040#_088fe910_6871_4276_9098_d3752d30edd7
boundary condition: true
initial concentration: NaN
is: Q9NRZ7
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:56894
name: AGPAT3

metaM gacpail hs r
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
name: glucosaminyl-acylphosphatidylinositol
is: HMDB01401
has only substance units: false
is: CHEBI:61548
boundary condition: false
is: C00092
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

metaR r1687
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110040#
reversible: false
product: MODEL1310110040#

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_292c6626_66cd_49f4_ae64_0aef75b28b68
type: Species
is: Q6IBA0
is encoded by: hsa:4725
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NDUFS5

metaR OCDCAtr
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true

metaR DNADtn
name: dNAD transport, nuclear trhough pore
is: SBO:0000185
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#

metaM dtdp e
is: SBO:0000247
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
initial concentration: 1.0
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
is: CHEBI:58369
initial amount: NaN
boundary condition: false
is: HMDB01274

metaR BDMT L
is version of: http://identifiers.org/ec-code/2.4.1.142
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
modifier: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)

metaM CE2839 e
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: C01936
is: http://identifiers.org/pubchem.compound/5041
name: maltodecaose
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaM 2425dhvitd2 m
boundary condition: false
is: CHEBI:28938
constant: false
name: 24R,25-Dihyoxyvitamin D2
initial amount: NaN
notes: FORMULA: C28H44O3 CHARGE: 0 INCHI: InChI=1/C28H44O3/c1-19-9-12-23(29)18-22(19)11-10-21-8-7-16-27(5)24(13-14-25(21)27)20(2)15-17-28(6,31)26(3,4)30/h10-11,15,17,20,23-25,29-31H,1,7-9,12-14,16,18H2,2-6H3/b17-15+,21-10+,22-11-/t20-,23-,24-,25+,27-,28-/m1/s1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00051
type: Species
is: C01342

metaM retinal cis 9 c
type: Species
name: all-trans-retinal
initial concentration: 1.0
boundary condition: false
is: CHEBI:17898
is: HMDB01358
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: SBO:0000247
constant: false

metaM hyptaur c
has only substance units: false
is: SBO:0000247
is: CHEBI:16668
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
boundary condition: false
name: Hypotaurine
initial amount: NaN

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110040#
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_7ffc8acd_3eb1_48eb_8c52_e1bde488df98
is encoded by: hsa:AI924226
type: Species
boundary condition: true
initial amount: NaN
name: _AI924226_1_m
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM fum m
type: Species
boundary condition: false
is: HMDB00134
name: Fumarate
initial amount: NaN
constant: false
is: C00122
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false

metaR r1682
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110040#
is: SBO:0000185
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_6cfc24f4_027f_4968_a29b_c67c888e2101
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2806
initial concentration: NaN
is: P00505
initial amount: NaN
name: GOT2

http://identifiers.org/biomodels.db/MODEL1310110040#_58403482_a1b8_4769_99f5_39cab4801cfe
initial amount: NaN
is encoded by: hsa:3032
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: HADHB
is: P55084
initial concentration: NaN

metaM 3tdcrn c
has only substance units: false
is: HMDB02014
boundary condition: false
type: Species
initial concentration: 1.0
name: 3-hydroxy-tetradecanoyl carnitine
notes: FORMULA: C21H41NO5 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0728
kinetic law: MODEL1310110040#
type: Reaction
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110040#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_8706519d_78e9_48d4_a327_9ebd80ed09ae
initial concentration: NaN
has only substance units: false
name: PYCR1
constant: false
is encoded by: hsa:5831
type: Species
is: SBO:0000252
boundary condition: true
is: A6NFM2
initial amount: NaN

metaM abt e
initial amount: NaN
name: L-arabinitol
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
has only substance units: false
constant: false
is: HMDB01851
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM CE5119 m
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: trans-3-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119

metaM btcoa x
type: Species
constant: false
is: HMDB01088
has only substance units: false
is: SBO:0000247
name: Butanoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: C00136
boundary condition: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4

metaM l2fn2m2masn g
constant: false
type: Species
boundary condition: false
notes: FORMULA: C68H113N4O49X CHARGE: 0
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:28067
initial amount: NaN

metaR NH4t3r
type: Reaction
reversible: true
modifier: MODEL1310110040#
name: ammonia transport via proton antiport
is described by: ECO:0000269
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#

metaM Tn antigen l
name: Tn antigen
boundary condition: false
initial concentration: 1.0
is: C04383
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species
has only substance units: false

metaR G14T14g
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction

metaR r0729
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110040#

metaR DM Ser Thr ly
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaR r1681
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_27a98cf2_75e7_4557_ab61_5a6cb84967c1
boundary condition: true
is: SBO:0000252
name: GALNT3
has only substance units: false
is: Q14435
constant: false
is encoded by: hsa:2591
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_dc25002f_6645_4025_bc4c_f056849ea7f4
boundary condition: true
constant: false
is: Q96M60
is encoded by: hsa:196951
is: SBO:0000252
has only substance units: false
name: C15orf33
initial amount: NaN
type: Species
initial concentration: NaN

metaR 2OXOADPTm
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reactant: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
reversible: true

metaR AG13T3g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110040#
reversible: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM ru5p D c
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
boundary condition: false
is: CHEBI:58121
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_8ebfbc66_3bb3_4658_baea_734dab103ba4
is encoded by: hsa:956
type: Species
name: ENTPD3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: O75355
initial amount: NaN
has only substance units: false
constant: false

metaM HC01412 x
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405

metaM 3octdece1coa c
boundary condition: false
is: SBO:0000247
is: HMDB13336
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
name: 3-hydroxyoctadecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110040#_36bed21d_ec42_4768_8b5a_500c88db4aa9
initial concentration: NaN
type: Species
is: Q96P26
boundary condition: true
is: SBO:0000252
is encoded by: hsa:93034
has only substance units: false
initial amount: NaN
constant: false
name: NT5C1B

metaR r1684
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110040#
reversible: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000

metaM 3hexdcrn e
type: Species
is: HMDB13336
name: 3-hydroxyhexadecanoylcarnitine
notes: FORMULA: C23H45NO5 CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR 35CGMPtn
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reactant: MODEL1310110040#
type: Reaction
name: 35cGMP nuclear transport
fast: false

metaM dpcoa l
initial concentration: 1.0
is: HMDB01373
constant: false
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
initial amount: NaN
name: 3'-dephospho-CoA(2-)
boundary condition: false
is: SBO:0000247
is: CHEBI:57328

metaR r0726
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
fast: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110040#_da2e5cd0_0a8b_46d3_b470_9b14bb71a780
is encoded by: hsa:10331
has only substance units: false
name: B3GNT3
boundary condition: true
initial amount: NaN
is: Q9Y2A9
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM lnlncacrn c
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
boundary condition: false
has only substance units: false
type: Species
name: alpha-linolenyl carnitine
is: HMDB06319

metaR NACHEXA20ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_faa1c27a_0566_4bc4_bdcc_000ae51e01cd
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:10020
has only substance units: false
is: B7Z428
constant: false
is: SBO:0000252
name: GNE

metaM dad 2 c
is: CHEBI:17256
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00101
initial amount: NaN
name: 2-deoxyadenosine

metaR MM5ag
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110040#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#

metaR METS
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.13
type: Reaction
name: methionine synthase
reversible: false

metaR GLRASE
is described by: ECO:0000000
name: glucuronolactone reductase
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#

metaR DMATTx
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
reactant: MODEL1310110040#
reversible: false
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.5.1.1
name: dimethylallyltranstransferase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#

metaR r0727
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
kinetic law: MODEL1310110040#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110040#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_fdff32fc_8a23_4ff6_859e_a150f9a449c1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: DPM2
is encoded by: hsa:8818
constant: false
initial amount: NaN

metaR r0074
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: true
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
fast: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM urate c
type: Species
constant: false
name: Urate
is: CHEBI:17775
initial concentration: 1.0
is: SBO:0000247
is: HMDB00289
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9678816f_fa5d_4db5_a33d_c85e4488c47d
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI935189
name: _AI935189_1_m
constant: false

metaR FE3R2e
name: Fe(III) reduction (ascorbate)
modifier: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD

metaM 3mgcoa m
is: HMDB01057
constant: false
is: CHEBI:57346
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: trans-3-methylglutaconyl-CoA(5-)
is: SBO:0000247
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231

metaM leuktrA4 e
constant: false
name: leukotriene A4(1-)
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
is: CHEBI:57463
is: HMDB01337

metaM nh4 m
is: HMDB00051
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: C01342
is: CHEBI:28938
type: Species
has only substance units: false
initial concentration: 1.0
name: Ammonium

metaM HC02207 c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
initial amount: NaN
is: CHEBI:27555
constant: false
initial concentration: 1.0
type: Species
name: prostaglandin-c2

metaM pe hs e
has only substance units: false
is: CHEBI:16038
constant: false
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

metaR r0724
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_902773bf_51c6_4bb8_8373_5e9cf4d1570e
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: P14618
name: PKM2
boundary condition: true
is encoded by: hsa:5315

metaR r1573
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#

metaM 3hexdcrn c
has only substance units: false
name: 3-hydroxyhexadecanoylcarnitine
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H45NO5 CHARGE: 0
constant: false
is: SBO:0000247
is: HMDB13336

metaR RETNt
name: retinoic acid transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction

metaM hdca c
has only substance units: false
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
is: HMDB00220
initial concentration: 1.0
type: Species
constant: false
name: palmitate
is: SBO:0000247
initial amount: NaN

metaM acgam r
is: SBO:0000247
has only substance units: false
type: Species
name: N-acetyl-D-glucosamine
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_76100f05_2154_4f82_97bd_e7ff22bb67c4
is encoded by: hsa:5281
name: PIGF
has only substance units: false
constant: false
is: Q07326
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_715f78cc_b19b_424b_8369_7007f9db81df
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:10999
constant: false
is: Q6P1M0
name: SLC27A4
boundary condition: true
is: SBO:0000252

metaM udpacgal c
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:57847
is: HMDB00304
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203

http://identifiers.org/biomodels.db/MODEL1310110040#_c20035ef_1fe5_4ca9_8de2_8ea948b8632c
initial amount: NaN
is: Q14117
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: DPYS
is encoded by: hsa:1807

metaM ksii core2 deg7 l
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57455
is: SBO:0000247
has only substance units: false
notes: FORMULA: C44H73N4O30X CHARGE: 0
name: keratan sulfate II (core 2-linked), degradation product 7
boundary condition: false
is: HMDB01354

http://identifiers.org/biomodels.db/MODEL1310110040#_84102e69_f60f_4578_b375_a5f411352d1e
is encoded by: hsa:6675
has only substance units: false
name: UAP1
type: Species
is: Q16222
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM dpcoa e
boundary condition: false
is: C00882
is: HMDB01373
initial amount: NaN
is: CHEBI:57328
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
name: Dephospho-CoA
initial concentration: 1.0

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
name: Beta oxidation of fatty acid
reversible: false
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_30365f9a_229b_4770_b340_69fd1f7cdd85
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: O95167
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4696
name: NDUFA3
initial concentration: NaN

metaR SEBACACT
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR NACHEX17ly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_24ba223b_6cf9_41af_9aa7_bf35efd3ae25
name: IDH1
constant: false
is encoded by: hsa:3417
initial concentration: NaN
initial amount: NaN
is: O75874
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaM pe hs c
boundary condition: false
is: CHEBI:16038
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false

metaR r0722
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.3.12

metaM 3tdcrn e
boundary condition: false
name: 3-hydroxy-tetradecanoyl carnitine
constant: false
has only substance units: false
initial amount: NaN
is: HMDB13336
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H41NO5 CHARGE: 0

metaM HC01522 c
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
boundary condition: false
name: Gentisate aldehyde
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28508
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_9f8a64d1_a9f9_4c9c_b156_c1a3496e2580
boundary condition: true
is: Q8IWW8
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:137872
has only substance units: false
name: ADHFE1

metaR r1575
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000

metaM bilirub e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57977
is: HMDB00054
name: bilirubin(2-)
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
has only substance units: false
type: Species

metaR C102CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM hdca e
is: HMDB00220
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
is: C00249
notes: FORMULA: C16H31O2 CHARGE: -1
name: Hexadecanoate (n-C16:0)
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaM CE5117 m
type: Species
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: CHEBI:15748
is: HMDB00127

metaM 2425dhvitd2 e
is: http://identifiers.org/pubchem.compound/3305
notes: FORMULA: C28H44O3 CHARGE: 0 INCHI: InChI=1/C28H44O3/c1-19-9-12-23(29)18-22(19)11-10-21-8-7-16-27(5)24(13-14-25(21)27)20(2)15-17-28(6,31)26(3,4)30/h10-11,15,17,20,23-25,29-31H,1,7-9,12-14,16,18H2,2-6H3/b17-15+,21-10+,22-11-/t20-,23-,24-,25+,27-,28-/m1/s1
is: SBO:0000247
constant: false
is: HMDB00902
name: 24R,25-Dihyoxyvitamin D2
initial amount: NaN
is: CHEBI:57540
is: C00003
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR r0723
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_2c3668ac_1205_4a1d_a2db_ab0b2e1fe351
is: Q9UNA3
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:51146
name: A4GNT
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaM 3hdeccoa m
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 3-hydroxyhexadecenoylcoa
is: HMDB02288
initial concentration: 1.0

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_7bc12fc0_eb64_4573_9032_54ff52809c6b
initial amount: NaN
is: A8K5Z0
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:8703
type: Species
name: B4GALT3
initial concentration: NaN

metaM acetol c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: CHEBI:27957
is: HMDB06961
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
name: hydroxyacetone
initial concentration: 1.0

metaR r1574
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110040#_52f3f114_07c5_4e72_8f20_1125a746803b
is encoded by: hsa:3141
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: P50747
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: HLCS

http://identifiers.org/biomodels.db/MODEL1310110040#_75e42f6f_72a3_4247_9caa_6298ba91e221
boundary condition: true
is: Q8N142
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:122622
is: SBO:0000252
name: ADSSL1
has only substance units: false
type: Species

metaR r2501
is described by: ECO:0000000
fast: false
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
reversible: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR CYTK3n
is described by: ECO:0000269
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110040#
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110040#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR TYRCBOX
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
name: L-Tyrosine carboxy-lyase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110040#_b3c8d560_1f5a_4bd0_b560_c2859dafdaa2
type: Species
has only substance units: false
name: DGKB
is: SBO:0000252
constant: false
is encoded by: hsa:1607
is: Q9Y6T7
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_7e6c0464_6883_4f8d_81d9_17b9167af326
has only substance units: false
is: Q53Y41
initial amount: NaN
name: DDC
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1644
initial concentration: NaN

metaR r0386
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
reversible: false

metaR r0720
product: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110040#

metaM gam c
name: D-Glucosamine
is: CHEBI:17315
is: HMDB01514
has only substance units: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial amount: NaN
is: C00329
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR r0934
product: MODEL1310110040#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110040#

metaM 5thf e
is: HMDB06487
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial amount: NaN
type: Species
is: SBO:0000247
name: pentaglutamyl folate (THF)
initial concentration: 1.0
boundary condition: false
constant: false

metaM HC02214 c
type: Species
is: CHEBI:28852
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false

metaR S3TASE3ly
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR r2015
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DGAT
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/2.3.1.20
is: SBO:0000176
modifier: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
name: diacylglycerol acyltransferase
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_0204425a_6a35_4219_b68e_f1b4a706d962
initial amount: NaN
is encoded by: hsa:196883
constant: false
type: Species
is: Q8NFM4
has only substance units: false
name: ADCY4
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_dafd27a0_493d_4319_823d_9d333712e608
has only substance units: false
is encoded by: hsa:8140
name: SLC3A2:SLC7A5
initial concentration: NaN
type: Species
is: SBO:0000297
boundary condition: true
has part: Q8IV97
initial amount: NaN
constant: false

metaM bilirub c
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57977
name: bilirubin(2-)
is: HMDB00054
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaR r2506
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110040#
name: Utilized transport
product: MODEL1310110040#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110040#

metaR BTNPLm
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110040#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.3.4.10
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_6b7e27c5_ee43_4cbc_b32c_dcdee0e3bc43
type: Species
name: ENTPD4
is: Q9Y227
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:9583

metaM 3aib D c
initial concentration: 1.0
name: D-3-Amino-isobutanoate
is: C03265
type: Species
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

metaM udpacgal g
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
is: CHEBI:57847
is: HMDB00304
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_01d7690f_d4b0_4043_b224_ca122d0e76e2
constant: false
name: ENO1
is encoded by: hsa:2023
initial concentration: NaN
initial amount: NaN
is: E2DRY6
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaM lnlncgcrn m
name: gamma-linolenyl carnitine
initial concentration: 1.0
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
initial amount: NaN
is: HMDB06318
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR r0721
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_bd9f29b6_5045_43f2_b841_715b25799d64
is: SBO:0000252
initial concentration: NaN
is: Q99643
boundary condition: true
has only substance units: false
initial amount: NaN
name: SDHC
type: Species
constant: false
is encoded by: hsa:6391

metaM 2425dhvitd2 c
is: http://identifiers.org/pubchem.compound/3305
notes: FORMULA: C28H44O3 CHARGE: 0 INCHI: InChI=1/C28H44O3/c1-19-9-12-23(29)18-22(19)11-10-21-8-7-16-27(5)24(13-14-25(21)27)20(2)15-17-28(6,31)26(3,4)30/h10-11,15,17,20,23-25,29-31H,1,7-9,12-14,16,18H2,2-6H3/b17-15+,21-10+,22-11-/t20-,23-,24-,25+,27-,28-/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00902
has only substance units: false
name: 24R,25-Dihyoxyvitamin D2
initial amount: NaN
is: C00003
is: CHEBI:57540

metaR r1764
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110040#
type: Reaction

metaM adn e
type: Species
has only substance units: false
constant: false
boundary condition: false
is: C00212
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: CHEBI:16335
is: HMDB00050
initial concentration: 1.0
name: Adenosine

metaM HC01412 m
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:61405
initial amount: NaN
initial concentration: 1.0
type: Species
name: trans-tetradec-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110040#_58b79670_23c6_4c69_aa17_f6260c184ecb
is: Q9H2B4
initial concentration: NaN
is encoded by: hsa:10861
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: SLC26A1

http://identifiers.org/biomodels.db/MODEL1310110040#_f2b27109_248b_4aab_949d_661cfb5e8ee9
has only substance units: false
is encoded by: hsa:2731
initial concentration: NaN
has part: P48728
initial amount: NaN
has part: P23378
type: Species
has part: P23434
boundary condition: true
is: SBO:0000297
is encoded by: hsa:275
is encoded by: hsa:2653
name: DLD:GCSH:GLDC:AMT
constant: false

metaM ksi pre13 g
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 13
initial concentration: 1.0
is: C00130
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
is: HMDB00175
constant: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species
initial amount: NaN

metaR r1576
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185

metaR r2507
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
kinetic law: MODEL1310110040#
name: Utilized transport
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM HC02207 e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:27555
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
constant: false
type: Species

metaR PDX5PO
type: Reaction
reversible: true
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.5
name: pyridoxine 5'-phosphate oxidase
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_90d6bcea_bc63_452e_8d34_5d373c0b287f
is: P48448
has only substance units: false
is encoded by: hsa:222
type: Species
is: SBO:0000252
initial concentration: NaN
name: ALDH3B2
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_777f396e_9cdf_441d_9dbd_52402d8fe057
is encoded by: hsa:6511
name: SLC1A6
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: P48664
type: Species
initial amount: NaN
is: SBO:0000252

metaM lnlncacrn m
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB06319
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: alpha-linolenyl carnitine

metaR r0388
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:

metaM sgalside hs c
initial concentration: 1.0
is: CHEBI:16523
is: HMDB03406
constant: false
type: Species
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: sulfatide galactocerebroside

http://identifiers.org/biomodels.db/MODEL1310110040#_5056a566_2d24_4585_9486_5c5ebfb417a9
is encoded by: hsa:6817
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
name: SULT1A1
initial concentration: NaN
initial amount: NaN

metaM but e
is: CHEBI:17968
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
is: HMDB00039
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false

metaM leuktrA4 c
is: CHEBI:57463
name: leukotriene A4(1-)
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01337

http://identifiers.org/biomodels.db/MODEL1310110040#_1ee5fbd0_d9a4_4dcd_bfed_c3593c762ea1
is encoded by: hsa:1666
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is: Q16698
name: DECR1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_05cc6006_4a90_4636_8d7c_8abd70cf0820
is: SBO:0000252
is encoded by: hsa:4731
boundary condition: true
is: P56181
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFV3
constant: false

metaR r2017
reversible: false
kinetic law: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM uacgam g
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
boundary condition: false
is: HMDB00290
initial concentration: 1.0
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
is: CHEBI:57705
initial amount: NaN
has only substance units: false

metaM HC02214 e
boundary condition: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
name: prostaglandin-f1alpha
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:28852
constant: false

metaR r1579
is: SBO:0000185
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLYt2r
name: glycine reversible transport via proton symport
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
type: Reaction

metaM ksii core4 pre1 g
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 1
is: CHEBI:28067
type: Species
notes: FORMULA: C36H60N3O25X CHARGE: 0

metaM Rtotal3coa c
is: SBO:0000247
name: R total 3 Coenzyme A
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
is: CHEBI:16189
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01448

metaR A MANASEly
name: alpha-mannosidase, lysosomal
kinetic law: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.24
reversible: false
fast: false
product: MODEL1310110040#
is: SBO:0000176
type: Reaction

metaR SUCCtp
name: succinate transporter, peroxisome
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ

metaR r0389
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
fast: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR RE2069C
type: Reaction
product: MODEL1310110040#
name: RE2069
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
is: SBO:0000176

metaM but c
constant: false
boundary condition: false
name: butyrate
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00039
initial amount: NaN
is: CHEBI:17968
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaM adn c
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
is: C00212
initial amount: NaN
is: CHEBI:16335
is: SBO:0000247
name: Adenosine
initial concentration: 1.0
is: HMDB00050

metaM dpcoa c
has only substance units: false
name: Dephospho-CoA
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57328
initial concentration: 1.0
type: Species
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: HMDB01373
initial amount: NaN

metaR ACGAMtly
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
name: N-acetyl-glucosamine lysosomal efflux

metaR r1578
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi deg19 l
is: HMDB01354
has only substance units: false
is: CHEBI:57455
name: keratan sulfate I, degradation product 19
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaM so4 l
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16189
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_46101b24_c65e_4138_980a_30f8f21afc5b
type: Species
name: GUSB
boundary condition: true
is: SBO:0000252
is: P08236
is encoded by: hsa:2990
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM ump c
boundary condition: false
name: UMP
type: Species
is: HMDB00288
has only substance units: false
initial amount: NaN
is: C00105
constant: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
is: SBO:0000247

metaR r2509
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#
name: Utilized transport
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true

metaR DPCOAPPe
type: Reaction
fast: false
product: MODEL1310110040#
is: SBO:0000176
name: Pyrophasphatase (dephospho-CoA, extracellular)
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

metaR GULLACter
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
name: gulonolactone endoplasmic reticular transport
fast: false
reversible: false
kinetic law: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_32ec6dd6_a54d_4a60_8b9a_bc1194fb6ed2
initial concentration: NaN
boundary condition: true
is: Q2TU34
name: FBP1
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2203

metaR NRPPHRSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110040#
is described by: ECO:0000269
fast: false
product: MODEL1310110040#
name: Norepinephrine Sulfotransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reversible: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction

metaM so4 m
initial concentration: 1.0
type: Species
is: CHEBI:16189
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
name: sulfate

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

metaR M4MPDOL Lter
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110040#
name: m4mpdol flippase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM hom L e
is: HMDB00719
name: L-homoserine
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:15699
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_3f3270c6_6e08_4d86_a56d_60c7ca4213ba
type: Species
is encoded by: hsa:6888
name: TALDO1
is: P37837
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_c95f93af_0352_4c2e_8cb3_4608b0172485
is encoded by: hsa:2987
initial concentration: NaN
name: GUK1
has only substance units: false
type: Species
boundary condition: true
is: Q16774
is: SBO:0000252
initial amount: NaN
constant: false

metaR HACD1m
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000134
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
fast: false
reversible: true
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_6c3ca153_aa4e_4630_bf32_4f4ea584b08f
name: _AA081045_1_e
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AA081045
has only substance units: false
initial amount: NaN

metaM HC01414 x
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275
has only substance units: false
initial concentration: 1.0
constant: false
name: trans-dec-2-enoyl-CoA(4-)
type: Species
is: SBO:0000247
is: CHEBI:61406

http://identifiers.org/biomodels.db/MODEL1310110040#_a4b9dc34_ddc9_488d_a020_a07e281e661a
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is: A6NN98
name: MTMR2
initial concentration: NaN
is encoded by: hsa:8898
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_59f41941_4c22_4bda_9496_d3659f0185eb
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q01959
boundary condition: true
name: SLC6A3
type: Species
is encoded by: hsa:6531
initial concentration: NaN

metaM HC00460 c
initial amount: NaN
is: CHEBI:58044
name: 2,5-dihydroxybenzoate
is: SBO:0000247
constant: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR RE2079R
name: RE2079
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaM HC02023 r
is: CHEBI:46898
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: Cholesterol-ester-ol
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110040#_da38fc88_dcde_482f_a4a0_9fd7e6ba2d22
type: Species
initial amount: NaN
is encoded by: hsa:7378
initial concentration: NaN
has only substance units: false
name: UPP1
boundary condition: true
constant: false
is: SBO:0000252

metaM omhdecacid c
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: w-hydroxydecanoicacid
notes: FORMULA: C10H19O3 CHARGE: -1
is: C08260
is: HMDB00672

http://identifiers.org/biomodels.db/MODEL1310110040#_153cc994_fb8b_4bed_a1ad_cdbef115ff95
type: Species
is encoded by: hsa:4710
boundary condition: true
is: O95168
is: SBO:0000252
constant: false
name: NDUFB4
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR 34HPPte
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
fast: false

metaR r0193
is described by: ECO:0000000
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0f51d207_7fb0_48ab_9145_80b536866280
constant: false
boundary condition: true
is: SBO:0000252
name: SLC26A9
has only substance units: false
is: Q7LBE3
type: Species
initial amount: NaN
is encoded by: hsa:115019
initial concentration: NaN

metaR PRPNCOAHYDm
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
name: Propenoyl-CoA hydrolase (m)
is: SBO:0000176
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110040#_26e7979b_7a96_4075_bd26_a3c64fbafe4d
type: Species
is encoded by: hsa:5213
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: P08237
name: PFKM
initial concentration: NaN

metaM fmn c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
name: FMN
is: C00061
initial amount: NaN
is: CHEBI:58210
is: SBO:0000247
type: Species
is: HMDB01520
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_1b539bae_a8a0_4378_ba62_0f11a5145a1b
initial concentration: NaN
has only substance units: false
name: NDUFA5
initial amount: NaN
is: Q16718
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4698
type: Species

metaR r0395
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
fast: false

metaM HC01397 m
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:27402
boundary condition: false
initial amount: NaN

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
product: MODEL1310110040#
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction

metaM Ser Thr g
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: CHEBI:58336
has only substance units: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00645

metaM dgchol e
type: Species
initial concentration: 1.0
is: CHEBI:36252
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00637
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate

metaM arachcoa m
is: HMDB04258
is: CHEBI:15527
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
constant: false

metaR UDPtl
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000000
reversible: true
type: Reaction
name: udp intracellular transport
fast: false

metaM ksi pre23 g
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
boundary condition: false
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r1010
product: MODEL1310110040#
name: Postulated transport reaction
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110040#
is: SBO:0000185

metaR 4NPHSULT
product: MODEL1310110040#
name: 4-Nitrophenol Sulfotransferase
modifier: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reversible: false

metaM pmtcrn c
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: SBO:0000247
initial amount: NaN
name: L-palmitoylcarnitine
boundary condition: false
is: HMDB00222
is: CHEBI:17490
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_05e8071c_5f8a_4e8b_81bc_23904f6051ae
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:1545
boundary condition: true
constant: false
is: SBO:0000252
is: Q16678
name: CYP1B1

http://identifiers.org/biomodels.db/MODEL1310110040#_8eb2db70_2e51_4560_9049_694d04a1b763
name: INPP5B
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: P32019
is encoded by: hsa:3633
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_264f1144_9e29_4b88_95fb_a434d15a4957
initial amount: NaN
name: SLC28A1
has only substance units: false
is: Q96PL7
initial concentration: NaN
is encoded by: hsa:9154
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaM Sfglutth c
constant: false
is: SBO:0000247
type: Species
is: HMDB01550
name: S-formylglutathionate(1-)
boundary condition: false
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57688
has only substance units: false

metaR r0393
modifier: MODEL1310110040#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_ba546d0a_b27f_4ad8_91be_e36d0bb32355
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5150
boundary condition: true
name: PDE7A
is: Q13946
constant: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR BILIRED
type: Reaction
reversible: false
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.1.24
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000176
name: Nad(p)h biliverdin reductase
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV

metaM chito2pdol L c
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01196
initial concentration: 1.0
constant: false
is: CHEBI:12427
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false

metaR NACHEX10ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM kynate c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: kynurenate
constant: false
type: Species
is: HMDB00715
initial concentration: 1.0
is: CHEBI:58454
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717

metaR r0191
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.24
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is described by: ECO:0000000

metaR DNDPt24m
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
name: dTDP transport via dADP antiport
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM gly e
is: C00037
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00123
initial concentration: 1.0
name: Glycine
initial amount: NaN
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: CHEBI:3339
boundary condition: false

metaM dgchol c
name: glycochenodeoxycholate
is: CHEBI:36252
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
initial amount: NaN
is: HMDB00637

metaR NADtpu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
name: NAD transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110040#_41682813_9522_4ceb_8773_8727c0c343d2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6448
is: P51688
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: SGSH

metaR SCP22x
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is: SBO:0000185
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
name: Sterol carrier protein 2
fast: false
reversible: true

metaM gq1b hs c
type: Species
is: HMDB00220
is: CHEBI:7896
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
has only substance units: false
is: SBO:0000247
name: GQ1b
initial amount: NaN
is: C00249

metaM acrn r
is: HMDB00201
initial concentration: 1.0
type: Species
is: CHEBI:57589
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR r0392
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110040#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3

metaM c51crn c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H21NO4 CHARGE: 0
initial amount: NaN
has only substance units: false
is: HMDB02366
initial concentration: 1.0
constant: false
type: Species
name: tiglyl carnitine

metaR UMPKn
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase, nuclear
reactant: MODEL1310110040#
reversible: true
is: SBO:0000176
modifier: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110040#

metaR GCCam
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
kinetic law: MODEL1310110040#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

metaM pchol hs m
has only substance units: false
name: Phosphatidylcholine
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
initial amount: NaN
is: CHEBI:16110

metaM Ser Thr l
notes: FORMULA: XH CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB06254
initial concentration: 1.0
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR r1459
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
name: Transport reaction

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11

metaR r1013
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Transport reaction
type: Reaction
reversible: false
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:

metaM CE4794 m
constant: false
initial concentration: 1.0
name: cis-6-dodecenoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaR r1014
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110040#
name: Postulated transport reaction
kinetic law: MODEL1310110040#
reversible: false

metaM lcts e
boundary condition: false
is: CHEBI:17716
is: C00243
name: Lactose
constant: false
is: HMDB00186
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaR r0390
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true
kinetic law: MODEL1310110040#
is: SBO:0000176
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
type: Reaction

metaR FAOXC1811602m
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid

metaM gq1b hs e
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
is: CHEBI:58115
has only substance units: false
initial amount: NaN
name: GQ1b
is: HMDB01397
type: Species

metaM c51crn e
boundary condition: false
name: tiglyl carnitine
notes: FORMULA: C12H21NO4 CHARGE: 0
is: HMDB02366
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_e957ac06_5615_4bfb_bcd4_a5c8218848f7
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P28332
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ADH6
is encoded by: hsa:130

metaR FAOXC3DC
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_519905df_d4a4_47fb_a47c_a41d4957e764
is: SBO:0000252
name: B3GNT7
type: Species
constant: false
is encoded by: hsa:93010
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q8NFL0

metaM dtdp m
is: C00363
name: dTDP
constant: false
is: HMDB01274
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_c9991c48_9abb_4043_9bd2_a9559b2d8bf6
has only substance units: false
boundary condition: true
name: COX5A
is encoded by: hsa:9377
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P20674
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_67c6dcd2_a4b3_4ecb_93c1_80783e47e6f2
is encoded by: hsa:3635
constant: false
initial amount: NaN
is: SBO:0000252
is: Q92835
type: Species
boundary condition: true
initial concentration: NaN
name: INPP5D
has only substance units: false

metaR THBPT4ACAMDASE
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
fast: false

metaM gd1c hs g
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00138
initial amount: NaN
has only substance units: false
constant: false
name: GD1c
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
is: CHEBI:58235

metaM acrn m
type: Species
boundary condition: false
is: HMDB00201
is: CHEBI:57589
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
name: O-acetylcarnitine
initial amount: NaN

metaR r2408
fast: false
modifier: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
reversible: false
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_5f8be630_a47a_4957_a885_b2afcf0274d4
name: TPI1P2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:286016
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM pmtcrn m
name: L-palmitoylcarnitine
is: SBO:0000247
is: HMDB00222
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:17490
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaM arachcoa c
type: Species
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB04258
has only substance units: false
initial amount: NaN
is: CHEBI:15527

metaM dtdp n
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB01274
has only substance units: false
is: CHEBI:58369
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_d65611bb_b6a1_4756_ad9f_abc03c61dd63
boundary condition: true
is: SBO:0000252
constant: false
name: COX8C
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q7Z4L0
is encoded by: hsa:341947
type: Species

metaM lald D c
constant: false
is: CHEBI:17167
is: HMDB06458
initial concentration: 1.0
is: SBO:0000247
name: (R)-lactaldehyde
type: Species
has only substance units: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
initial amount: NaN
boundary condition: false

metaM ser L c
is: HMDB00187
constant: false
name: L-serine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17115
type: Species

metaR ADPCOACROT
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_abfb915e_5a46_43ea_a065_c18a34985be3
boundary condition: true
initial concentration: NaN
name: NDUFA11
constant: false
type: Species
is encoded by: hsa:126328
is: C9JT23
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_01591040_180e_4302_84f4_78cc5799e4aa
is: Q96N66
has only substance units: false
constant: false
name: MBOAT7
type: Species
is encoded by: hsa:79143
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR OCTAt
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
name: Octanoate transport via diffusion
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reversible: true
is: SBO:0000185

metaR RE3627M
product: MODEL1310110040#
fast: false
reversible: true
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110040#
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaM 20ahchsterol m
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: CHEBI:1296
constant: false
boundary condition: false
name: 20-hydroxycholesterol
is: SBO:0000247
is: HMDB06283
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false

metaM gd1c hs e
initial concentration: 1.0
constant: false
name: GD1c
is: HMDB00138
boundary condition: false
initial amount: NaN
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
has only substance units: false
is: SBO:0000247
type: Species

metaM mal L m
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00156
has only substance units: false
type: Species
is: CHEBI:15589
constant: false

metaR ACALDtm
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110040#
name: acetaldehyde mitochondrial diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM ksi deg41 l
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
name: keratan sulfate I, degradation product 41

metaM apoC Lys btn c
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: HMDB00182
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:32551
constant: false
is: SBO:0000247
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)

http://identifiers.org/biomodels.db/MODEL1310110040#_28ad7ef4_8c90_4cee_8cce_6232cfd6d020
is encoded by: hsa:3032
initial concentration: NaN
has part: E9KL44
has part: P55084
type: Species
name: HADHA:HADHB
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3030
initial amount: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110040#_535ce3da_d657_4605_ac39_372aeb152465
is: B3KRT1
has only substance units: false
type: Species
is encoded by: hsa:51477
initial amount: NaN
constant: false
name: ISYNA1
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_379c85ab_52dd_4019_8b87_fe96a157a36f
constant: false
name: LDHA
is encoded by: hsa:3939
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: P00338
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a28a952a_ada7_46f4_896e_b827ec445901
is: Q04760
initial concentration: NaN
is encoded by: hsa:2739
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: GLO1
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_4ee1bab1_940b_4b06_961d_940d602af3f2
is: P02794
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2495
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: FTH1

metaR OCCOAtx
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_406c1c06_bb8f_4bbf_b3cf_ed6a8b525395
has only substance units: false
type: Species
name: _728226_1_m
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:728226
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_bd689fa5_bbba_48c0_a736_7cf2c2b7219d
initial concentration: NaN
constant: false
name: BDH1
has only substance units: false
is encoded by: hsa:622
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM ser L e
name: L-serine
constant: false
is: CHEBI:17115
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_9790c364_8583_4b2d_ba00_7abf588a19b3
constant: false
type: Species
boundary condition: true
name: SLC6A5
initial amount: NaN
is encoded by: hsa:9152
is: Q9Y345
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_c7d21947_ae0c_4b25_a05e_d2855e288099
boundary condition: true
initial amount: NaN
type: Species
name: LDHB
initial concentration: NaN
is: SBO:0000252
is: P07195
is encoded by: hsa:3945
constant: false
has only substance units: false

metaM gly c
constant: false
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0
is: CHEBI:3339
initial concentration: 1.0
is: HMDB00123
name: Glycine
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: C00037

http://identifiers.org/biomodels.db/MODEL1310110040#_05ac32f7_5900_4a29_86cf_3682959b4968
type: Species
initial concentration: NaN
initial amount: NaN
is: Q96PE7
is: SBO:0000252
is encoded by: hsa:84693
boundary condition: true
constant: false
name: MCEE
has only substance units: false

metaM dag hs c
boundary condition: false
constant: false
is: SBO:0000247
name: diglyceride
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_c1cdc59f_6918_4bec_bd2a_c766bc891837
is encoded by: hsa:6535
name: SLC6A8
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: B4DIA3
constant: false

metaR FAOXC2242046m
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110040#_439ec1d9_5d62_4e21_9ee9_efc8c9eaa3e6
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2639
is: Q92947
has only substance units: false
name: GCDH
initial amount: NaN
constant: false
boundary condition: true

metaM pmtcrn r
name: L-palmitoylcarnitine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: HMDB00222
is: CHEBI:17490
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaM thbpt4acam n
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
has only substance units: false
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
is: CHEBI:15374
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR r1453
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
fast: false
type: Reaction
product: MODEL1310110040#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaM fru e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: SBO:0000247
boundary condition: false
has only substance units: false
name: D-Fructose
is: CHEBI:15824
is: C00095
initial concentration: 1.0
is: HMDB00660

metaM bilirub r
is: CHEBI:57977
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: bilirubin(2-)
initial concentration: 1.0
is: HMDB00054
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false

metaM prostgf2 c
constant: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01139
is: CHEBI:57404
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

metaM pchol hs e
is: CHEBI:16110
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
name: Phosphatidylcholine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_373a32fd_5e93_457c_b786_171cb0ceaad4
is encoded by: hsa:80025
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: PANK2
is: SBO:0000252

metaR NTP3e
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: nucleoside-triphosphatase (GTP)

metaR 5ADTSTSTERONEtr
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
name: 5 alpha dihydrotesterone intracellular transport
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
product: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_249aab7c_09cc_45d0_9f64_21cd4cb88709
has only substance units: false
boundary condition: true
is: Q9UI32
is encoded by: hsa:27165
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GLS2

metaR r1454
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110040#
reversible: false
type: Reaction
product: MODEL1310110040#

metaR r2403
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110040#
reactant: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ac7bf82a_2d8f_438f_8cce_5a3761194188
is: SBO:0000252
constant: false
has only substance units: false
is: P33121
initial amount: NaN
name: ACSL1
type: Species
is encoded by: hsa:2180
boundary condition: true
initial concentration: NaN

metaR C6CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_9234f859_e663_4ace_88d4_68bef8d2f0f1
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4714
is: O95169
name: NDUFB8
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR r1451
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: EC:1.3.3.6
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_0e8ad494_fdfa_4537_bd99_cd95b9e85daa
initial amount: NaN
name: CANT1
is encoded by: hsa:124583
is: Q8WVQ1
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_96fe7ede_47f8_4682_b140_40da6b764e6d
has part: Q07326
type: Species
is: SBO:0000297
has part: Q8TEQ8
initial amount: NaN
name: PIGF:PIGO
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84720
boundary condition: true
is encoded by: hsa:5281

metaM adp x
initial concentration: 1.0
initial amount: NaN
is: CHEBI:456216
is: HMDB01341
has only substance units: false
name: ADP(3-)
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
boundary condition: false
constant: false

metaR PALFATPtc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaM acnam c
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: CHEBI:35418
is: HMDB00230
is: SBO:0000247
name: N-acetylneuraminate

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM pchol hs c
initial amount: NaN
boundary condition: false
is: CHEBI:16110
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
type: Species

metaR r0196
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110040#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000

metaR HSD3A2r
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_f5e4f04d_2c42_4b9c_968f_d68e093a1004
boundary condition: true
is: Q9H2F3
is: SBO:0000252
is encoded by: hsa:80270
has only substance units: false
name: HSD3B7
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_e8294ebd_a411_41c1_97a3_48be4c4882b5
initial amount: NaN
is encoded by: hsa:57786
name: RBAK
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: Q9NYW8
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_465f5895_4c4e_44b5_894f_83fd8e18d0eb
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4842
is: B4DG68
is: SBO:0000252
name: NOS1
initial concentration: NaN
has only substance units: false

metaR r2405
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c3420562_4878_4a0b_9e51_c74d6f1c3823
has only substance units: false
initial amount: NaN
constant: false
is: B2R6S5
initial concentration: NaN
is encoded by: hsa:51727
is: SBO:0000252
name: CMPK1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_76e467f1_03bd_47cf_b4ea_1cca62b48360
has only substance units: false
is: SBO:0000252
name: GLB1
boundary condition: true
is encoded by: hsa:2720
is: P16278
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaM hom L c
name: L-homoserine
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:15699
boundary condition: false
is: HMDB00719
initial amount: NaN

metaM i c
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
is: CHEBI:16382
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: iodide
boundary condition: false
initial amount: NaN

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR DATPtn
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
name: dATP diffusion in nucleus
reversible: true
kinetic law: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_4289ede8_d371_4ae1_9520_6067e89e169f
name: _AV717590_1_m
initial concentration: NaN
is encoded by: hsa:AV717590
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r0719
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.153
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
product: MODEL1310110040#

metaM c4dc e
type: Species
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H18NO6 CHARGE: -1
is: HMDB02013
boundary condition: false
constant: false
name: succinyl carnitine
has only substance units: false
initial amount: NaN
is: C02862

metaR r0081
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
modifier: MODEL1310110040#
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r0940
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
fast: false
name: Free diffusion
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM adp r
name: ADP(3-)
is: HMDB01341
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
initial amount: NaN

metaR r0718
fast: false
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.181
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#

metaR PROSTGF2t
kinetic law: MODEL1310110040#
is: SBO:0000185
type: Reaction
name: prostaglandin uniport
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

metaR PNP
name: purine-nucleoside phosphorylase
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
modifier: MODEL1310110040#
type: Reaction

metaR NMNATn
is version of: http://identifiers.org/ec-code/2.7.7.1
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_676caf32_752c_455a_af45_3af1f84310cb
boundary condition: true
type: Species
initial amount: NaN
name: _BE042354_1_m
is: SBO:0000252
constant: false
is encoded by: hsa:BE042354
initial concentration: NaN
has only substance units: false

metaR UMPK
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110040#
product: MODEL1310110040#
name: UMP kinase
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_0ac46d05_a3a1_4d51_8a39_14b28c1fc489
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PIGA
is encoded by: hsa:5277
is: B3KUV7
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR C181CPT1
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: transport of Octadecenoyl-CoA into mitochondrial matrix
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#

metaM ksii core4 deg3 l
is: HMDB00143
name: keratan sulfate II (core 4-linked), degradation product 3
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:12936
constant: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
boundary condition: false

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM mal L c
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: (S)-malate(2-)
is: SBO:0000247
initial concentration: 1.0

metaR IVCOAACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR AMETtd
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
name: diffusion of S-Adenosyl-L-methionine
is described by: ECO:0000134
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#

metaR r0941
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Free diffusion
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_293fd618_7db6_4a14_ac79_9ab60d027b2c
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: PDE1A
has only substance units: false
is encoded by: hsa:5136
is: P54750

http://identifiers.org/biomodels.db/MODEL1310110040#_8ff73edb_d903_4f17_8978_d8c66e6fa90c
has part: Q6FIH7
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:516
has only substance units: false
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true

metaR ARACHDt2
kinetic law: MODEL1310110040#
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185

metaR LNELDCCRNt
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110040#
reversible: false
is: SBO:0000185
product: MODEL1310110040#

metaR r1569
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110040#
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM imp e
boundary condition: false
has only substance units: false
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
is: SBO:0000247
name: IMP(2-)
initial amount: NaN
type: Species
is: CHEBI:58053
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_065ebb73_ff47_4b42_af79_098de24920e1
is: SBO:0000252
is encoded by: hsa:645
type: Species
name: BLVRB
boundary condition: true
has only substance units: false
is: P30043
initial amount: NaN
initial concentration: NaN
constant: false

metaR AG13T13g
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
fast: false
product: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM 2mb2coa m
has only substance units: false
type: Species
is: CHEBI:57337
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB02054
is: SBO:0000247
name: 2-methylcrotonoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345

metaR LINOFATPtc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_f696a070_3afd_45dc_a62d_349936cacb0b
boundary condition: true
is: SBO:0000252
type: Species
is: P14060
constant: false
initial concentration: NaN
is encoded by: hsa:3283
initial amount: NaN
has only substance units: false
name: HSD3B1

metaR q10h2tc
kinetic law: MODEL1310110040#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110040#
name: transport of ubiquinol into cytosol
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_8925413f_cc85_4f37_97e9_d484f45f44d1
is: SBO:0000252
is: P07741
name: APRT
is encoded by: hsa:353
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM pnto R c
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:7916
name: (R)-Pantothenate
boundary condition: false
type: Species

metaR r0942
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_2c4b129e_14ac_457f_af0f_b3849438c874
name: TUSC3
type: Species
initial amount: NaN
is: Q13454
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:7991

metaR HS2ly
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
name: heparan-N-sulfatase, lysosomal
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110040#

metaR r1568
reactant: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM fru c
boundary condition: false
constant: false
name: D-Fructose
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:15824
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
has only substance units: false
is: C00095
is: HMDB00660
initial amount: NaN

metaM mal L e
name: (S)-malate(2-)
constant: false
is: HMDB00156
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15589

metaR r1772
modifier: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110040#
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110040#

metaM ksi pre1 g
initial concentration: 1.0
is: HMDB00175
type: Species
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 1
is: C00130
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
initial amount: NaN

metaM ksi pre12 g
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
type: Species
is: C00130
is: CHEBI:58053
boundary condition: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 12

http://identifiers.org/biomodels.db/MODEL1310110040#_c7aa2a24_eecf_4dc7_acef_5dd1b8ee774e
type: Species
initial amount: NaN
name: CHAT
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1103
is: P28329

metaM acnam l
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0
boundary condition: false
is: HMDB00230
has only substance units: false
is: CHEBI:35418
name: N-acetylneuraminate
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4958172c_30bc_4c2f_b504_e48f0fabcbd3
is: SBO:0000252
is: Q9H6R3
name: ACSS3
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:79611
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_a04a72b4_6837_4112_ae24_0cc20c70acf5
name: BTD
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: P43251
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:686

metaM imp c
initial concentration: 1.0
is: SBO:0000247
name: IMP
boundary condition: false
has only substance units: false
is: CHEBI:58053
constant: false
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
initial amount: NaN
is: C00130

metaM adp n
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
name: ADP(3-)
is: HMDB01341
initial concentration: 1.0
has only substance units: false
is: CHEBI:456216
is: SBO:0000247

metaM Rtotal2coa c
is: C00055
is: CHEBI:60377
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
name: R total 2 coenzyme A
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00095
is: SBO:0000247
initial amount: NaN
type: Species

metaM ksi deg22 l
is: HMDB01354
initial amount: NaN
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
boundary condition: false
is: CHEBI:57455
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 22
constant: false
type: Species
has only substance units: false

metaM pnto R e
name: (R)-Pantothenate
constant: false
is: HMDB00210
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:7916
has only substance units: false

metaR CRNtx
name: carnitine transport peroxisome to mitochondria
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#

metaR RTOTALt
is described by: ECO:0000000
reversible: true
name: RTOTAL transport
is: SBO:0000185
product: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110040#

metaM gncore2 g
notes: FORMULA: C30H50N3O20X CHARGE: 0
boundary condition: false
is: CHEBI:15876
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: GlcNAc-alpha-1,4-Core 2
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_edffb9a0_e0e1_4f78_b1ce_4e6738b14e87
name: EGFR
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1956
initial amount: NaN
is: P00533
is: SBO:0000252
boundary condition: true
constant: false

metaR r0714
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
kinetic law: MODEL1310110040#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
reactant: MODEL1310110040#

metaR C3STKR2r
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
type: Reaction
fast: false
reversible: false
name: C-3 sterol keto reductase (zymosterol)
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000134
kinetic law: MODEL1310110040#

metaR r0085
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176
modifier: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9a7c55f6_4f58_47e4_89a4_4b2b757321b5
initial concentration: NaN
type: Species
is: Q8TBF5
is encoded by: hsa:54965
name: PIGX
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR KSII CORE2tly
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110040#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110040#
fast: false

metaR TCYNTt
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110040#

metaR r1671
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000

metaR BILIRUBtr
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110040#
reversible: true

metaR NMNATr
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110040#
reversible: true

metaM adp m
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: ADP
is: CHEBI:456216
initial concentration: 1.0
is: SBO:0000247
is: C00008
is: http://identifiers.org/pubchem.compound/3310
is: HMDB01341

metaM prpncoa m
has only substance units: false
is: CHEBI:57367
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307
constant: false
name: acryloyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e457a694_9964_4c49_9377_b51736d871bc
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55350
name: VNN3
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaM acnam n
is: CHEBI:35418
is: HMDB00230
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: N-acetylneuraminate

metaR LINKDEG2ly
is: SBO:0000176
kinetic law: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110040#
type: Reaction
fast: false
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110040#

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
initial amount: NaN
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
boundary condition: false
type: Species
is: CHEBI:58053
is: C00130
has only substance units: false
is: HMDB00175
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR DDECCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR r0086
reversible: false
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
is: SBO:0000176
fast: false

metaR r0715
is version of: http://identifiers.org/ec-code/6.3.2.5
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_ff41e341_bfa8_4eb5_91d6_6d87fc1712d0
is encoded by: hsa:57084
initial amount: NaN
is: Q9P2U8
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC17A6
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b694363b_a74a_4df2_b056_ca315f2cad95
constant: false
is encoded by: hsa:8972
initial amount: NaN
type: Species
boundary condition: true
is: O43451
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: MGAM

metaR SERATB0tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Serine into the intestinal cells by ATB0 transporter
type: Reaction

metaM dag hs n
has only substance units: false
type: Species
name: diglyceride
constant: false
is: CHEBI:18035
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_a598c4b0_365f_42b9_a057_40f621cb7d17
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:NM 013421
initial amount: NaN
name: _NM_013421_1_e

metaR AG13T2g
product: MODEL1310110040#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is: SBO:0000176
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_95fe32a0_2ae6_4334_9041_00f212601477
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NDUFA3
boundary condition: true
initial amount: NaN
is: O95167
type: Species
is encoded by: hsa:4696
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b018120e_c9f9_4ca0_9554_27bd657ca0b5
boundary condition: true
initial amount: NaN
constant: false
is: O15382
type: Species
is encoded by: hsa:587
is: SBO:0000252
name: BCAT2
has only substance units: false
initial concentration: NaN

metaR r0716
is: SBO:0000176
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#

metaR TTDCPT1
is described by: ECO:0000269
kinetic law: MODEL1310110040#
name: carnitine O-palmitoyltransferase
product: MODEL1310110040#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR r0083
modifier: MODEL1310110040#
type: Reaction
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110040#

metaM nicrnt n
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01132
type: Species
is: CHEBI:57502
name: nicotinate D-ribonucleotide(2-)
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C11H12NO9P CHARGE: -2 INCHI: InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p-2/t7-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185

metaR r1670
name: Y+LAT2 Utilized transport
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_890ee29f_2c4d_4219_a62b_785b3adb099d
is: P49914
name: MTHFS
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:10588
is: SBO:0000252

metaR KSII CORE4t
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core4) transport, golgi to extracellular
reversible: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction

metaR CYTK2n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110040#
reversible: true
is: SBO:0000176
name: cytidylate kinase (dCMP),nuclear
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaM tdcoa c
initial amount: NaN
is: SBO:0000247
is: CHEBI:57385
is: HMDB01521
boundary condition: false
is: C02593
has only substance units: false
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false
initial concentration: 1.0

metaM dopa c
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
is: CHEBI:59905
type: Species
name: dopaminium(1+)
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5781bead_d7a0_4471_a808_405d5f7de111
is: Q11203
initial concentration: NaN
type: Species
is encoded by: hsa:6487
has only substance units: false
name: ST3GAL3
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin H2(1-)
initial concentration: 1.0
initial amount: NaN
is: HMDB01381
type: Species
is: CHEBI:57405

metaR NAGA2ly
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.49
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
name: N-acetylgalactosaminidase, alpha-
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
reactant: MODEL1310110040#

metaR TTDCPT2
name: carnitine transferase
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#

metaR r0717
product: MODEL1310110040#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_757c1db2_5988_4a2a_8e9d_25bbf6ba7e99
has only substance units: false
is: Q9HBH5
initial amount: NaN
initial concentration: NaN
name: RDH14
constant: false
is: SBO:0000252
is encoded by: hsa:57665
type: Species
boundary condition: true

metaM thbpt4acam c
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
initial concentration: 1.0
constant: false
is: CHEBI:15374
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false

metaR PLA2 2
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.4
modifier: MODEL1310110040#
name: phospholipase A2
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM 1glyc hs e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00972
is: CHEBI:57454
name: 1 acyl phosphoglycerol

metaR DNDPt17m
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is: SBO:0000185
name: dUDP transport via dCDP antiport
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000269

metaR r1779
type: Reaction
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM dlnlcg e
constant: false
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247
initial concentration: 1.0
is: HMDB02925
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_91f98283_21f3_4f98_9e11_d7263d8b844d
has only substance units: false
initial concentration: NaN
type: Species
is: B3KMA6
name: ACSL3
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2181
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d6936b63_9fc0_46f1_8a1c_a91f62440245
initial amount: NaN
has only substance units: false
is: O75355
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:956
boundary condition: true
name: ENTPD3
is: SBO:0000252

metaM 4ppan c
is: HMDB01016
constant: false
name: D-4'-Phosphopantothenate
initial amount: NaN
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: C03492

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR S6T18g
reversible: false
fast: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110040#

metaR NAIt
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110040#

metaR EX c8crn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR D3AIBTm
reversible: true
kinetic law: MODEL1310110040#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_932e2e6f_217c_465f_a17b_726b5ab28b53
is: SBO:0000252
is encoded by: hsa:125061
has only substance units: false
type: Species
initial concentration: NaN
is: Q63HM1
initial amount: NaN
boundary condition: true
name: AFMID
constant: false

metaR r1563
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#

metaR DOLP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000176
name: dolichol phosphate flippase (liver)
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false
fast: false

metaR DHCR72r
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.21
is described by: ECO:0000269
product: MODEL1310110040#
type: Reaction
name: 7-dehydrocholesterol reductase
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2a69b1c7_768e_4dba_9805_42baf0e19d23
is: Q6FGV9
initial concentration: NaN
constant: false
is encoded by: hsa:10654
boundary condition: true
name: PMVK
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8b59f064_1502_4e4f_b553_ff7b204fb5fc
name: HK3
has only substance units: false
type: Species
is: P52790
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3101
is: SBO:0000252
initial amount: NaN
constant: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM m8masn r
boundary condition: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C05876
constant: false

metaR S2TASE2ly
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110040#

metaM 3hdececrn e
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB13325
initial concentration: 1.0
notes: FORMULA: C23H43NO5 CHARGE: 0
constant: false
name: 3-hydroxyhexadecenoylcarnitine

metaM prostgh2 c
is: HMDB01381
type: Species
is: CHEBI:57405
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
name: prostaglandin H2(1-)
boundary condition: false

metaM dopa e
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
is: CHEBI:59905
initial amount: NaN
is: SBO:0000247
name: dopaminium(1+)
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_87a5174d_7ef8_4860_b5a5_7901fc58c86f
is: O15305
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5373
name: PMM2
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_f5578705_9f7f_4561_939c_3929000c8145
boundary condition: true
type: Species
has only substance units: false
name: GCH1
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2643
is: SBO:0000252
is: Q8IZH9

metaR S6TASE26ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_6b9b3afb_f911_4a6e_aee5_6e55ce65410a
type: Species
has only substance units: false
is encoded by: hsa:29988
name: SLC2A8
boundary condition: true
is: Q9NY64
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaR G14T15g
reversible: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR r1562
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaR RE3520E
modifier: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
name: RE3520
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000

metaR ADNt
fast: false
name: adenosine facilated transport in cytosol
is described by: ECO:0000269
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#

metaR DITPtn
is: SBO:0000185
name: dITP nuclear transport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true

metaM dlnlcg c
boundary condition: false
type: Species
is: SBO:0000247
name: dihomo-gamma-linolenic acid (n-6)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
has only substance units: false
is: HMDB02925
constant: false

metaR H2O2tp
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
name: hydrogen peroxide peroxisomal transport via diffusion
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
reversible: true

metaR r2514
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110040#
reversible: true
product: MODEL1310110040#
fast: false

metaM odecoa m
type: Species
constant: false
is: CHEBI:57387
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
is: HMDB01322
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_db0b1bec_1c74_4a95_b10d_7d5583d63b20
is: P00390
initial amount: NaN
is encoded by: hsa:2936
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: GSR
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_733145a6_2b26_4748_8bc0_29d3d905abc9
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: FOLR1
type: Species

metaM dag hs r
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: CHEBI:18035
name: diglyceride
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1018
product: MODEL1310110040#
name: Transport reaction
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_b68ca67e_1edf_4f86_82e2_2eb0907ca7e0
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: PDE8A
has only substance units: false
boundary condition: true
is encoded by: hsa:5151
is: SBO:0000252

metaR r1561
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
fast: false
is: SBO:0000185
reactant: MODEL1310110040#

metaR CLS hs
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110040#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
name: cardiolipin synthase (homo sapiens)
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_6c314fe5_ed63_4819_8e91_9235d1d4a266
is: Q96DU7
is encoded by: hsa:80271
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: ITPKC
has only substance units: false

metaR PROSTGI2t
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
product: MODEL1310110040#
is: SBO:0000185
type: Reaction
name: Prostaglandin I2 transport
fast: false
reactant: MODEL1310110040#
reversible: true

metaR r1560
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR THP2Ctp
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110040#_c6fb6e49_6173_47e4_ad6e_d1ec854df6ed
initial amount: NaN
constant: false
is: Q9BWD1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ACAT2
type: Species
is encoded by: hsa:39

http://identifiers.org/biomodels.db/MODEL1310110040#_57ba1643_abf4_4fd9_86ab_527310d40f9d
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: CHPT1
is encoded by: hsa:56994
is: Q8WUD6
initial concentration: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR S4TASE2ly
kinetic law: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
fast: false
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_ec28ff42_6e10_4cb7_82ca_4ba963015f0e
initial concentration: NaN
constant: false
name: _AA526438_1_c
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AA526438
boundary condition: true

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a9975bc1_6449_40ba_bbb0_72770da1fcf9
type: Species
constant: false
is: SBO:0000297
is encoded by: hsa:5213
has part: P08237
boundary condition: true
initial concentration: NaN
name: PFKM:PFKP
initial amount: NaN
has only substance units: false

metaR r2024
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false

metaR ITCOAL1m
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
reversible: true
reactant: MODEL1310110040#
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000304

metaM btcoa c
boundary condition: false
type: Species
is: SBO:0000247
name: Butanoyl-CoA
is: CHEBI:57371
initial amount: NaN
is: C00136
has only substance units: false
initial concentration: 1.0
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a409d78d_3d0a_4ebd_9137_c7089e8d6ccf
name: NDUFS4
is encoded by: hsa:4724
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: O43181
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7f05a6dc_5133_498e_8bed_deee48d24fbb
initial concentration: NaN
name: OAT
has only substance units: false
type: Species
is: P04181
is: SBO:0000252
is encoded by: hsa:4942
constant: false
boundary condition: true
initial amount: NaN

metaR r0944
type: Reaction
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
name: Active transport
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR GLCNACT L
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110040#
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (liver)
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR ACGAMPM
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
name: phosphoacetylglucosamine mutase
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/5.4.2.3
type: Reaction

metaM HC01397 x
type: Species
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:27402
is: SBO:0000247
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA
has only substance units: false

metaM gtp e
initial concentration: 1.0
constant: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
name: GTP(4-)
has only substance units: false
boundary condition: false
type: Species
is: HMDB01273
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_ae7f3065_d157_46a7_a179_f38d4e271e68
type: Species
name: _R06874_1_r
is encoded by: hsa:R06874
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR r1567
kinetic law: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#

metaR r2516
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NBAHH ir
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
is described by: ECO:0000134
product: MODEL1310110040#
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.13.20
fast: false
kinetic law: MODEL1310110040#
type: Reaction
reversible: false
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_f64aba23_3070_4c79_975b_521aeaf558df
constant: false
type: Species
has only substance units: false
name: HK1
is encoded by: hsa:3098
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: B3KXY9

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
name: valine transaminase, mitochondiral
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
fast: false
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_502d0333_6157_430e_a561_e3bf81686a4e
is encoded by: hsa:10678
initial concentration: NaN
is: Q9NY97
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: B3GNT2
has only substance units: false
boundary condition: true

metaR C14OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR PROSTGE1t
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110040#
name: prostaglandin transport via bicarbonate countertransport
reversible: true
type: Reaction
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185

metaM apoC Lys btn m
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: http://identifiers.org/pubchem.compound/7886
constant: false
is: C05552
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
is: HMDB03134

metaR r1988
is: SBO:0000185
fast: false
modifier: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport

metaR r1566
reactant: MODEL1310110040#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000

metaM ksi pre32 g
has only substance units: false
initial amount: NaN
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 32
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28067

metaR r1019
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
reactant: MODEL1310110040#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_cf09a4df_1c0b_4e33_a39a_2f7eb0263d04
is encoded by: hsa:6534
type: Species
is: SBO:0000252
is: Q99884
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: SLC6A7

metaM ksi deg30 l
type: Species
is: CHEBI:12936
constant: false
boundary condition: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
has only substance units: false
name: keratan sulfate I, degradation product 30
initial amount: NaN
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0

metaR r0946
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110040#

metaR NACHEX19ly
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110040#
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction

metaR RE0944E
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
name: RE0944
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_6737609f_ae66_49f6_8c6c_e7363563fa54
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: GMPPB
has only substance units: false
type: Species
is encoded by: hsa:29925

metaR FATP4t
kinetic law: MODEL1310110040#
name: fatty acid electroneutral transport
type: Reaction
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_42b6a409_52a1_4051_b91d_e6a7ac9a1ecf
is encoded by: hsa:2182
name: ACSL4
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: O60488
type: Species
initial amount: NaN
has only substance units: false

metaM acrn x
is: CHEBI:57589
name: O-acetylcarnitine
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00201
initial concentration: 1.0
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
has only substance units: false

metaR GALASE19ly
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110040#
reversible: false
name: beta-galactosidase, lysosomal

metaR r2518
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
kinetic law: MODEL1310110040#

metaR C181CPT2
reversible: false
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM gtp c
is: HMDB01273
initial amount: NaN
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
has only substance units: false
is: CHEBI:37565
is: C00044
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR r1565
kinetic law: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110040#
fast: false

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_cfe6021a_0cc6_452a_8f02_19153742c937
name: ALG2
initial concentration: NaN
is encoded by: hsa:85365
is: Q9H553
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_eaf47b55_a16b_495e_a38e_1d9472f2546c
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: PDE5A
constant: false
is encoded by: hsa:8654
initial concentration: NaN

metaR PETOHMm hs
type: Reaction
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110040#
name: phosphatidylethanolamine N-methyltransferase

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM lgnc c
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB02003
type: Species
name: lignocerate
is: SBO:0000247
is: CHEBI:31014
constant: false
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547

metaM 3hdececrn c
constant: false
name: 3-hydroxyhexadecenoylcarnitine
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB02014
notes: FORMULA: C23H43NO5 CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR r1776
reactant: MODEL1310110040#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110040#

metaR r0399
kinetic law: MODEL1310110040#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reactant: MODEL1310110040#

metaM tetdece1coa c
initial amount: NaN
initial concentration: 1.0
is: HMDB05066
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
type: Species
name: tetradecenoylcoa
constant: false
boundary condition: false

metaR DTMPK
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: dTMP kinase
is version of: http://identifiers.org/ec-code/2.7.4.9
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR r2519
is: SBO:0000185
is described by: ECO:0000000
name: Utilized transport
reversible: true
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaM odecoa r
is: HMDB01322
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: oleoyl-CoA(4-)
type: Species
is: CHEBI:57387

metaR r1564
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaM ksi deg17 l
is: CHEBI:12936
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
boundary condition: false
is: HMDB00143
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 17
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_2891c830_4589_4eab_bf4b_e09601b9a81a
name: BTD
boundary condition: true
constant: false
is: P43251
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:686
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_d0632ee5_a1d7_42e2_8331_3e802bb4d04d
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3945
initial concentration: NaN
initial amount: NaN
has part: P07195
type: Species
is encoded by: hsa:3939
has part: P00338
is: SBO:0000297
name: LDHA:LDHB

metaR DSAT
fast: false
kinetic law: MODEL1310110040#
reversible: false
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
name: dihydrosphingosine N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110040#_957b846b_592a_44d7_83c3_7b6829c37f47
name: _AU149534_1_c
initial concentration: NaN
is encoded by: hsa:AU149534
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR EX 25hvitd2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_aaa69a41_31af_43f4_aec7_90ec8d7ded10
initial concentration: NaN
initial amount: NaN
name: GMPPB
type: Species
is: Q9Y5P6
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:29925
has only substance units: false

metaM crn c
name: L-Carnitine
type: Species
is: HMDB00062
is: CHEBI:16347
is: C00318
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110040#_b8e4d8ce_fa3e_4f82_b504_c00e47e5a0ce
initial amount: NaN
boundary condition: true
type: Species
is: O00219
is: SBO:0000252
name: HAS3
initial concentration: NaN
constant: false
is encoded by: hsa:3038
has only substance units: false

metaM decdicrn c
has only substance units: false
type: Species
boundary condition: false
is: HMDB13325
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_01e47068_d64f_427b_974a_8c6c36b5b35e
is encoded by: hsa:6718
initial concentration: NaN
is: P51857
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: AKR1D1
has only substance units: false

metaR UGALNACtg
name: UDP-GalNAc Golgi transport via CMP antiport
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_61d08f12_090c_4759_aef8_020187b3fb79
initial concentration: NaN
constant: false
name: UCK2
type: Species
initial amount: NaN
is encoded by: hsa:7371
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9BZX2

metaR EX c16dc
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_9dda432d_b813_4b03_8030_cc91e2530846
name: SLC2A5
type: Species
initial concentration: NaN
is: P22732
is encoded by: hsa:6518
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_fdd66c05_2207_4a9a_81b3_195d14dc8431
has only substance units: false
is encoded by: hsa:51227
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: PIGP
is: SBO:0000252
boundary condition: true

metaR FACOAL2042
product: MODEL1310110040#
name: fatty-acid--CoA ligase
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reversible: true
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176

metaM ksi pre20 g
initial concentration: 1.0
boundary condition: false
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 20
constant: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
has only substance units: false
is: SBO:0000247
type: Species

metaM thymd e
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
is: CHEBI:17748
has only substance units: false
initial concentration: 1.0
is: C00214
is: HMDB00273
initial amount: NaN
is: SBO:0000247

metaM HC00250 c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: hydrosulfide
is: CHEBI:29919
has only substance units: false

metaM dhcholestanate c
is: CHEBI:16577
is: HMDB00359
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaM HC02210 e
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-d3
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
boundary condition: false

metaR METLEUex
modifier: MODEL1310110040#
name: Methionine/Leucine exchange (Met in)
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
product: MODEL1310110040#
type: Reaction

metaM chsterol r
has only substance units: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: cholesterol

metaM ksii core4 deg2 l
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00143
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 2

metaR PI4PLCn
is described by: ECO:0000269
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
product: MODEL1310110040#

metaM ksii core2 pre3 g
initial concentration: 1.0
is: CHEBI:58053
constant: false
initial amount: NaN
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 3
is: C00130
type: Species
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
is: HMDB00175
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_e8697542_6137_4183_bce3_bc2df99356f9
type: Species
is: Q9BR01
is encoded by: hsa:25830
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SULT4A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_0b96c972_271e_4472_8e44_120acdb13623
boundary condition: true
is encoded by: hsa:205
initial concentration: NaN
constant: false
type: Species
name: AK4
is: P27144
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4b274100_9f64_4f0b_9ead_88ce20cadec4
is encoded by: hsa:112
initial concentration: NaN
is: O43306
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ADCY6
has only substance units: false
constant: false

metaM decdicrn e
type: Species
is: HMDB13325
has only substance units: false
boundary condition: false
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaR SUCCTD
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_c0d72bb3_b7b3_4e44_b378_06735ab46107
initial concentration: NaN
name: SLC26A3
boundary condition: true
initial amount: NaN
is: P40879
has only substance units: false
is encoded by: hsa:1811
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e89f0d57_502b_43ce_9963_911f4f77365c
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: GPX5
type: Species
is encoded by: hsa:2880
is: SBO:0000252
is: O75715
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b1511f5e_c7cc_4a95_8d46_f09048a7ca98
initial amount: NaN
boundary condition: true
is: P54687
has only substance units: false
name: BCAT1
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:586

metaM mev R x
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00227
has only substance units: false
is: SBO:0000247
name: (R)-mevalonate

metaM ksi deg1 e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 1
has only substance units: false
constant: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
type: Species
is: SBO:0000247
is: HMDB00211
is: CHEBI:17268

metaM thymd c
is: CHEBI:17748
initial amount: NaN
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
is: C00214
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00273
has only substance units: false
constant: false

metaR MELATNOX
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110040#
fast: false
name: Melatonin:NADP oxidoreductase
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.48
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110040#

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction

metaM dd2coa c
constant: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB03712
name: trans-Dodec-2-enoyl-CoA
has only substance units: false
initial amount: NaN

metaM HC00250 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false
type: Species
is: CHEBI:29919
name: hydrosulfide
initial amount: NaN
is: SBO:0000247
constant: false

metaM mercplac c
is: http://identifiers.org/pubchem.compound/8118
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C05823
is: HMDB02127
has only substance units: false
boundary condition: false
initial amount: NaN
name: 3-Mercaptolactate
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7aa3eae4_c73a_4ed9_a448_b4bda0b78f5a
has only substance units: false
constant: false
initial amount: NaN
name: ABAT
type: Species
initial concentration: NaN
is: P80404
is: SBO:0000252
is encoded by: hsa:18
boundary condition: true

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:34939
type: Species
name: prostaglandin-d3

http://identifiers.org/biomodels.db/MODEL1310110040#_844e506b_deb1_430c_bf99_209e7772bd96
is encoded by: hsa:55343
initial concentration: NaN
name: SLC35C1
is: B3KQH0
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true

metaR r0917
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR EX gp1calpha hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GP1c alpha (homo sapiens) exchange
type: Reaction

metaR MECOAS1m
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is: SBO:0000176
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110040#
type: Reaction
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR FUMTSULtm
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
modifier: MODEL1310110040#
name: Fumarate:thiosulfate antiport, mitochondrial
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR GALt1r
product: MODEL1310110040#
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110040#
name: galactose transport (uniport)
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_87dbae01_d879_4133_ab8d_a01173a4aa5b
name: _AA977580_1_c
constant: false
type: Species
is encoded by: hsa:AA977580
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_631e63a6_0546_453e_a6d2_dca89fc2d260
initial amount: NaN
is: Q99643
name: SDHC
has only substance units: false
is encoded by: hsa:6391
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_1ce446ba_92ae_4ac9_b626_45badc69ff67
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:1603
boundary condition: true
initial concentration: NaN
name: DAD1
has only substance units: false
is: Q53G02
constant: false

metaM chsterol m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
type: Species
is: CHEBI:16113
is: HMDB00067

metaM adp c
initial amount: NaN
is: C00008
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:16761
is: SBO:0000247
name: ADP
is: HMDB01341
type: Species
is: http://identifiers.org/pubchem.compound/3310
has only substance units: false

metaR GCHOLAte
is described by: ECO:0000000
kinetic law: MODEL1310110040#
name: bile acid intracellular transport
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
fast: false
type: Reaction

metaM HC01401 x
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:27668
initial amount: NaN
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false
type: Species

metaR BTNDm
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
is: SBO:0000176
type: Reaction
name: biotinidase (biotin), mitochondrial
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT

http://identifiers.org/biomodels.db/MODEL1310110040#_c0d744e7_4e95_4340_96f6_275811a4d3d5
boundary condition: true
name: NDUFV1
constant: false
type: Species
is: E5KNH5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4723

http://identifiers.org/biomodels.db/MODEL1310110040#_ffa7db1c_ceea_4cb9_bb88_61aba755a4d3
is: F5H123
type: Species
has only substance units: false
name: DYLX2
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9856

metaM lgt S c
boundary condition: false
is: HMDB01066
constant: false
is: CHEBI:57474
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
type: Species
name: (R)-S-lactoylglutathionate(1-)
initial amount: NaN

metaM acald e
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
has only substance units: false
initial concentration: 1.0
is: CHEBI:15343
boundary condition: false
type: Species
name: acetaldehyde
initial amount: NaN
constant: false
is: SBO:0000247

metaM Rtotalcoa c
constant: false
is: CHEBI:16189
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: R total Coenzyme A
is: HMDB01448
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_d0430fe2_1f6a_4884_bd17_d5ae262499e6
constant: false
initial concentration: NaN
has part: P22392
is: SBO:0000297
name: NME1:NME2
boundary condition: true
has part: P15531
is encoded by: hsa:4830
initial amount: NaN
type: Species
is encoded by: hsa:4831
has only substance units: false

metaM lgnc e
is: HMDB02003
has only substance units: false
name: lignocerate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
type: Species
constant: false
is: CHEBI:31014

metaM crn e
is: C00318
is: CHEBI:16347
name: L-Carnitine
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR TPI
is: SBO:0000176
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reversible: true
kinetic law: MODEL1310110040#
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_99994257_b602_4902_8bff_549fbf74e4a5
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11254
is: SBO:0000252
is: Q9UN76
name: SLC6A14
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM ksi deg29 l
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
type: Species
is: HMDB00143
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: SBO:0000247
name: keratan sulfate I, degradation product 29

metaR H2Otly
is: SBO:0000185
type: Reaction
name: H2O transport, lysosomal
kinetic law: MODEL1310110040#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#

metaM tdcoa x
initial concentration: 1.0
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
is: C02593
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaM ksi pre4 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 4
is: HMDB00175
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:58053
is: SBO:0000247
initial amount: NaN
is: C00130
type: Species
notes: FORMULA: C101H165N7O72X CHARGE: -1

metaR BDHm
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

metaR CYSGLUexR
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110040#
is described by: ECO:0000304
type: Reaction
name: L-cysteine/L-glutamine reversible exchanger
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#

metaM dolmanp L c
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human liver homolog
has only substance units: false
is: CHEBI:15809
initial concentration: 1.0
constant: false
boundary condition: false

metaM psyltchol e
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9642032H15428745NO8667421S CHARGE: 0
constant: false
boundary condition: false
name: psyllium-taurocholic acid complex
is: http://identifiers.org/pubchem.compound/93131

http://identifiers.org/biomodels.db/MODEL1310110040#_a66bbd7c_3693_4454_8c27_45bd5d3e4a92
is encoded by: hsa:NOS2A
name: _NOS2A_1_c
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR RE0583C
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
is: SBO:0000176
name: RE0583
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9defc2c3_8754_4f7c_bda1_cb6ec2ceaae1
is: P04066
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: FUCA1
initial concentration: NaN
is encoded by: hsa:2517
is: SBO:0000252

metaR C40CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaR NDP7g
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110040#
fast: false
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_158997d4_d66b_4852_b532_15ce06adcc28
is: Q5TDP6
initial amount: NaN
is encoded by: hsa:51557
is: SBO:0000252
initial concentration: NaN
type: Species
name: LGSN
constant: false
has only substance units: false
boundary condition: true

metaR CYTK12n
fast: false
is described by: ECO:0000269
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_4dcdcfbd_d601_48c2_8861_80b0de96e21d
constant: false
name: CH25H
is: O95992
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:9023
type: Species

metaR r1487
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
name: EC:6.2.1.3
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: true
is described by: ECO:0000000

metaM dgtp c
boundary condition: false
name: dGTP
constant: false
has only substance units: false
is: HMDB01440
is: SBO:0000247
type: Species
initial amount: NaN
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_7e43bb02_3a66_4fd4_bed6_4c3cb66a7585
is encoded by: hsa:79369
has only substance units: false
is: Q9C0J1
constant: false
initial concentration: NaN
name: B3GNT4
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

metaR NDPK1n
type: Reaction
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
fast: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110040#

metaR AGTim
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.44
is: SBO:0000176
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110040#

metaR CHLPCTD
modifier: MODEL1310110040#
reversible: false
is described by: ECO:0000269
name: choline phosphate cytididyltransferase
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.7.15
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction

metaR DNDPt27m
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: dCDP transport via dTDP antiport

metaM HC01401 m
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
constant: false
is: CHEBI:27668
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_14e697fa_f4b5_4df3_b490_35f1f0f7eeda
is encoded by: hsa:1650
name: DAD1:DDOST:RPN1:RPN2
is: SBO:0000297
has part: P04843
boundary condition: true
has part: P39656
is encoded by: hsa:6184
initial amount: NaN
has only substance units: false
constant: false
type: Species
has part: Q53G02
has part: P04844
initial concentration: NaN
is encoded by: hsa:1603
is encoded by: hsa:6185

metaM pheme e
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false
name: Protoheme
is: SBO:0000247
is: HMDB03178
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:17627
is: C00032

http://identifiers.org/biomodels.db/MODEL1310110040#_4eb445bb_3ae5_49d1_9421_6e0db95b9201
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: Q96KN2
initial amount: NaN
name: CNDP1
is encoded by: hsa:84735
constant: false

metaM dd2coa m
initial concentration: 1.0
is: SBO:0000247
is: HMDB03712
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57330
name: trans-dodec-2-enoyl-CoA(4-)
initial amount: NaN
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221

http://identifiers.org/biomodels.db/MODEL1310110040#_56fefc45_faa2_4045_b1bf_a33d4936fa14
is encoded by: hsa:6241
is: SBO:0000252
constant: false
name: RRM2
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: P31350
initial amount: NaN

metaR CRNCARtp
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: carnitine-acetylcarnitine carrier, peroxisomal
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#

metaM malthp e
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: maltoheptaose
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: C01936

metaR HEXDIACTD
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaR EBASTINEOHtr
name: xenobiotic transport
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_9fefd78c_eb72_4710_876d_4845a11d491b
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8402
boundary condition: true
constant: false
has only substance units: false
type: Species
name: SLC25A11
is: F5GY65

metaR FBA2
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true

metaR PAIL45P HStn
is: SBO:0000185
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM dgtp e
name: dGTP
initial amount: NaN
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
is: SBO:0000247
is: HMDB01440
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM tdcoa m
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01521
boundary condition: false

metaR HSAT2ly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_043f9ecb_bbcc_44ce_bcb4_25766846fc70
constant: false
has only substance units: false
is encoded by: hsa:AV727634
name: _AV727634_1_c
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR r0163
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000176
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873,PMID:3207422 NOTES:
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
fast: false

metaR RE3565C
is: SBO:0000176
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
name: RE3565

metaM strdnccoa c
constant: false
is: SBO:0000247
is: HMDB06519
initial amount: NaN
boundary condition: false
has only substance units: false
is: C16163
type: Species
name: stearidonyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: http://identifiers.org/pubchem.compound/47205473

metaM acald c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: SBO:0000247
name: acetaldehyde
is: HMDB00990
type: Species
is: CHEBI:15343
initial amount: NaN
constant: false
boundary condition: false

metaR FAOXOHMC10DC10c
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHMC10-->DC10)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1f9672f1_0aff_457e_a172_9daccb1b0751
constant: false
type: Species
is encoded by: hsa:AI090874
is: SBO:0000252
initial amount: NaN
name: _AI090874_1_c
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ff18d9c0_8ed0_4e5a_a037_28113999534e
boundary condition: true
has only substance units: false
is encoded by: hsa:6578
is: Q92959
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: SLCO2A1

metaR H7 TAer
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
name: H7' transamidase, endoplasmic reticulum
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM ach c
boundary condition: false
constant: false
is: HMDB00895
initial amount: NaN
type: Species
is: CHEBI:15355
name: acetylcholine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaR SO4HCOtex
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000304
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
name: sulfate transport via bicarbonate countertransport
modifier: MODEL1310110040#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110040#_d87f4aeb_33b3_49d8_940f_e22403ce68f1
is: SBO:0000252
constant: false
name: _AA419122_1_c
type: Species
is encoded by: hsa:AA419122
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_0242f6ea_b212_4bad_86e2_bf5ec3cd05d2
is: O60733
name: PLA2G6
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8398
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM his L e
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
type: Species
constant: false
initial concentration: 1.0
name: L-histidine
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:15971

metaR r0165
reversible: false
kinetic law: MODEL1310110040#
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110040#
fast: false
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110040#

metaR AHC
type: Reaction
is version of: http://identifiers.org/ec-code/3.3.1.1
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: adenosylhomocysteinase
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110040#_95d55fb0_4e29_4213_8992_84a6f9a194ea
is: P04844
is encoded by: hsa:6185
type: Species
initial amount: NaN
boundary condition: true
name: RPN2
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM core4 g
name: Core 4
has only substance units: false
boundary condition: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16478
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_a02de517_c3b5_4e5f_a096_59f684200497
initial concentration: NaN
initial amount: NaN
is: P21953
has only substance units: false
name: BCKDHB
type: Species
is encoded by: hsa:594
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a3981b51_c76e_4789_b680_ce2c4984240d
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:3037
name: HAS2
initial amount: NaN
is: Q92819

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM glyc3p x
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: C00093
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57597
is: HMDB00126
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_0346b4fc_7025_4bd0_be08_d80e74ed068b
type: Species
initial amount: NaN
is encoded by: hsa:84343
has only substance units: false
is: Q969F9
boundary condition: true
name: HPS3
is: SBO:0000252
initial concentration: NaN
constant: false

metaM mi14p c
is: SBO:0000247
is: HMDB00968
initial concentration: 1.0
is: CHEBI:58282
has only substance units: false
initial amount: NaN
constant: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220

http://identifiers.org/biomodels.db/MODEL1310110040#_6daa9e57_29dd_451d_bd77_6c052cc69f36
has only substance units: false
type: Species
is encoded by: hsa:NM 013421
initial amount: NaN
constant: false
initial concentration: NaN
name: _NM_013421_1_m
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_2e03b9cc_a5b6_4836_b929_1c475efc07c1
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9ULC5
is encoded by: hsa:51703
name: ACSL5

http://identifiers.org/biomodels.db/MODEL1310110040#_028fb072_f988_4d98_be74_ccc2fecb2313
type: Species
is encoded by: hsa:224
initial concentration: NaN
initial amount: NaN
constant: false
name: ALDH3A2
is: SBO:0000252
has only substance units: false
is: P51648
boundary condition: true

metaM ach e
constant: false
is: HMDB00895
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
boundary condition: false
name: acetylcholine
is: SBO:0000247
has only substance units: false

metaR KSII CORE2t
is described by: ECO:0000000
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
name: keratan sulfate II (core2) transport, golgi to extracellular
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM his L c
name: L-histidine
is: HMDB00177
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971

metaR r1116
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
product: MODEL1310110040#

metaR C181CRNt
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
name: C181 transport into the mitochondria
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
kinetic law: MODEL1310110040#

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

metaR r0809
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
reversible: true
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM fdp c
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
boundary condition: false
is: http://identifiers.org/pubchem.compound/3647
initial amount: NaN
is: HMDB01058
constant: false
name: D-Fructose 1,6-bisphosphate
is: SBO:0000247
is: CHEBI:16905
initial concentration: 1.0
is: C00354
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_7f160037_ff56_4ca2_9e70_a4a3064e7b39
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: PDE4C
initial amount: NaN
is encoded by: hsa:5143
is: Q7KYS4
initial concentration: NaN
type: Species

metaM hs deg22 l
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: CHEBI:21338
initial concentration: 1.0
notes: FORMULA: C37H56NO35S CHARGE: -3
is: HMDB02704
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4e4ab21f_ab93_4b3c_b92d_95f14e73cb6f
name: _AI620219_1_e
boundary condition: true
is encoded by: hsa:AI620219
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaM pheme c
is: HMDB03178
constant: false
name: Protoheme
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:17627
is: C00032
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032

metaR SUCOASm
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
name: Succinate--CoA ligase (ADP-forming)
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR C51CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b23edc17_00af_4dfd_91c5_d210afffbd50
initial amount: NaN
type: Species
is encoded by: hsa:2819
is: SBO:0000252
constant: false
name: GPD1
is: F8W1L5
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR RE3626M
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110040#
product: MODEL1310110040#
name: RE3626
reversible: false
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR r1117
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110040#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
name: Facilitated diffusion
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
reversible: true

metaR GLNS
is: SBO:0000176
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000254
fast: false
product: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
name: glutamine synthetase
kinetic law: MODEL1310110040#

metaR APOC LYS BTNP
type: Reaction
is: SBO:0000176
name: proteolysis of apoC-Lys-btn
reactant: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a26bdf61_bdef_47eb_a2b2_aeb5240400f7
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q9UJA2
is: SBO:0000252
is encoded by: hsa:54675
name: CRLS1

metaR CYSTGLUex
product: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
name: L-cystine/L-glutamate exchanger

metaR r1260
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
product: MODEL1310110040#
name: EC:6.2.1.3
type: Reaction
fast: false

metaR r1781
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#

metaR RE2659R
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: RE2659
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true

metaM strdnccoa m
boundary condition: false
initial amount: NaN
is: HMDB06519
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: C16163
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205473
has only substance units: false
constant: false
name: stearidonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110040#_709fdb4a_f797_4082_b301_671f19712f1c
constant: false
name: ST6GALNAC2
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:10610
boundary condition: true
is: Q9UJ37
is: SBO:0000252

metaR CYTK1m
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
is: SBO:0000176
type: Reaction
fast: false
name: cytidylate kinase (CMP),mitochondrial
kinetic law: MODEL1310110040#
is described by: ECO:0000134
reactant: MODEL1310110040#

metaM mi14p n
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
is: HMDB00968
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

metaM octdececoa m
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: HMDB06294
name: octadecenoylcoa

metaM ump n
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57865
has only substance units: false
name: UMP(2-)
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR S6TASE22ly
kinetic law: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110040#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110040#
fast: false
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000

metaR NDP7ex
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
reactant: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
name: nucleoside-diphosphatase (UDP), extracellular
is described by: ECO:0000269
modifier: MODEL1310110040#
fast: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR HEX4
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
kinetic law: MODEL1310110040#
name: hexokinase (D-mannose:ATP)
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
reactant: MODEL1310110040#
is described by: ECO:0000304

metaM amet c
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
is: C00019
name: S-Adenosyl-L-methionine
is: CHEBI:15414
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01185
constant: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_f8491d27_ee69_4411_a115_aee9085fa7aa
is encoded by: hsa:6484
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q6IBE6
has only substance units: false
name: ST3GAL4
boundary condition: true
type: Species

metaM pmtcoa m
has only substance units: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
is: SBO:0000247
is: C00154
boundary condition: false
constant: false
type: Species

metaR CO2t
kinetic law: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
type: Reaction
name: CO2 transporter via diffusion
reversible: true
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_e7710a23_2d58_4491_822d_ddb1ad5fa2f4
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4832
name: NME3
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: Q13232

http://identifiers.org/biomodels.db/MODEL1310110040#_69aa10e8_caff_4116_80a1_2880d2177709
is encoded by: hsa:517
constant: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:9551
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
has part: F8W7V3
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

metaM chsterol c
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00067
boundary condition: false
name: cholesterol
type: Species
initial concentration: 1.0
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial amount: NaN

metaM ksi deg11 l
constant: false
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: HMDB00143
name: keratan sulfate I, degradation product 11
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaM ibcoa m
constant: false
name: isobutyryl-CoA(4-)
type: Species
initial amount: NaN
is: HMDB01243
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57338
boundary condition: false

metaR DCMPDA
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.4.12
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
name: dCMP deaminase
is: SBO:0000176
reversible: true
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false

metaM cdpdag hs m
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
initial amount: NaN
boundary condition: false

metaR CHOLtu
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110040#
product: MODEL1310110040#
name: Choline uniport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
type: Reaction

metaR HS1ly
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
fast: false
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction

metaM dhf m
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:57451
is: HMDB01056
name: dihydrofolate(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM c226coa c
constant: false
is: SBO:0000247
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110040#_8df13979_bb51_443f_b202_445afcb6a479
type: Species
is encoded by: hsa:28232
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q9UIG8
initial amount: NaN
boundary condition: true
name: SLCO3A1

http://identifiers.org/biomodels.db/MODEL1310110040#_6a4895c6_f139_4039_8905_b4e6a7628f40
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: ENPP1
is: SBO:0000252
is: P22413
boundary condition: true
is encoded by: hsa:5167

metaR O2Stm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: true
fast: false
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110040#

metaM ficytC m
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
name: Ferricytochrome c
initial concentration: 1.0
is: CHEBI:15991
has only substance units: false
constant: false
initial amount: NaN

metaM gd1c hs c
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: GD1c
type: Species
is: CHEBI:58235
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
has only substance units: false
is: HMDB00138

metaR S6TASE11ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM omhdecacid r
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
name: w-hydroxydecanoicacid
initial concentration: 1.0
is: HMDB06870
constant: false
initial amount: NaN
is: C05998
notes: FORMULA: C10H19O3 CHARGE: -1
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d0adb8a5_6ee8_4360_8058_d0a30a1077c6
initial concentration: NaN
is: SBO:0000252
name: ALDH3B1
is: P43353
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:221

metaR CERT1rt
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
type: Reaction
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
reversible: true
reactant: MODEL1310110040#
name: ceramide transport protein

metaM crn r
initial concentration: 1.0
type: Species
is: CHEBI:16347
is: HMDB00062
is: SBO:0000247
name: (R)-carnitine
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
initial amount: NaN
constant: false

metaR KSItly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
name: keratan sulfate I transport, extracellular to lysosome
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false

metaR ACOAO7p
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110040#
type: Reaction
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
fast: false
product: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM dhf l
has only substance units: false
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
name: dihydrofolate(2-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57451
boundary condition: false
is: HMDB01056
type: Species

metaR CYTK1n
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110040#
name: cytidylate kinase (CMP),nuclear
fast: false
product: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#

metaR NACHEX13ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
product: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110040#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110040#

metaM prostgf2 e
is: HMDB01139
initial concentration: 1.0
type: Species
constant: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: CHEBI:57404
has only substance units: false
initial amount: NaN
boundary condition: false

metaR CHOLtn
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
type: Reaction
name: Choline transport, nuclear through pores
is described by: ECO:0000000

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_9f8d1620_d81a_4e39_979a_65bf9d1fa44d
initial concentration: NaN
constant: false
name: NDUFS1
is: P28331
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4719
boundary condition: true
type: Species

metaR r0801
reactant: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
reversible: true
product: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110040#_fb4cad37_acc4_4244_b805_3e990c5bfc6d
type: Species
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
has part: Q06055
is encoded by: hsa:517

http://identifiers.org/biomodels.db/MODEL1310110040#_6c2638db_e1ab_49a5_9f33_b6f489ffd72c
type: Species
name: GALT
is: E7ET32
constant: false
initial amount: NaN
is encoded by: hsa:2592
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_8f9e95e8_e9b4_4c9c_a049_a8837b245064
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:56474
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: Q9NRF8
name: CTPS2

metaR r1557
fast: false
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_469c6c62_47f6_4b43_a5fa_19912b884e5d
constant: false
initial amount: NaN
is: O00400
name: SLC33A1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9197

metaM ksi deg26 l
type: Species
is: CHEBI:58343
is: HMDB00061
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: keratan sulfate I, degradation product 26
is: SBO:0000247
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
initial concentration: 1.0

metaM gluala e
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C03740
is: HMDB06248
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
has only substance units: false

metaM crn x
type: Species
is: CHEBI:16347
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00062
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
is: C00318
name: L-Carnitine

metaM ach n
boundary condition: false
initial concentration: 1.0
is: HMDB00895
is: CHEBI:15355
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine

metaR CHSTEROLtrc
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
type: Reaction
name: transport of cholesterol into the cytosol
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.

metaM ump r
is: SBO:0000247
has only substance units: false
is: HMDB00288
initial amount: NaN
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: CHEBI:57865
initial concentration: 1.0
boundary condition: false
name: UMP

metaM acrn c
initial concentration: 1.0
initial amount: NaN
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: CHEBI:57589
is: SBO:0000247
type: Species
name: O-acetylcarnitine
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_99da6441_46ac_472d_a019_e4399cc83520
has only substance units: false
name: _BF195998_1_x
constant: false
is encoded by: hsa:BF195998
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR r1556
type: Reaction
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR SQLSr
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction
is described by: ECO:0000134
fast: false
name: Squalene synthase
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110040#
product: MODEL1310110040#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110040#_5f3d7d8d_8091_4f26_bf7f_271523af6dfc
type: Species
name: _AA854479_1_m
constant: false
is encoded by: hsa:AA854479
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR FACOAL80i
reversible: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000269
name: fatty-acid--CoA ligase (octanoate)
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110040#

metaR GP1CALPHAte
fast: false
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
name: gp1calpha hs transport
reversible: true

metaR r1896
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_18b13ec3_10a6_4fce_a6b9_c26d679d14ed
initial amount: NaN
boundary condition: true
is encoded by: hsa:6582
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
name: SLC22A2
type: Species

metaM lthstrl r
initial concentration: 1.0
is: CHEBI:17168
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01170
name: 5alpha-cholest-7-en-3beta-ol
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_6d9a08af_2dd4_4b8f_8553_e510997a9216
is encoded by: hsa:AV713053
name: _AV713053_1_m
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_af0cfd9c_8867_402b_8951_49e4091f5989
type: Species
is: SBO:0000252
is encoded by: hsa:1337
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: COX6A1
is: P12074
constant: false
has only substance units: false

metaM dd2coa x
boundary condition: false
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57330
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_9afa9cfa_d25d_4592_aff7_60bdeef45ead
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8398
initial concentration: NaN
is: A8K460
name: PLA2G6
is: SBO:0000252
constant: false
type: Species

metaR r0706
is version of: http://identifiers.org/ec-code/1.3.99.10
reversible: false
modifier: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
type: Reaction
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110040#

metaR NDPK1m
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110040#
fast: false
reversible: true
product: MODEL1310110040#
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

http://identifiers.org/biomodels.db/MODEL1310110040#_4dca39f2_7617_432b_87cf_7b9dcd69ae8a
is: Q9Y2T3
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9615
name: GDA
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaR r1559
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110040#

metaM dolmanp L r
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:15809
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
name: Dolichyl phosphate D-mannose, human liver homolog

http://identifiers.org/biomodels.db/MODEL1310110040#_0c15c727_bdbe_428c_b00d_d43bc4b8521b
name: PLCB2
is encoded by: hsa:5330
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: Q59F77
initial amount: NaN
type: Species

metaR UDPG4E
type: Reaction
name: UDPglucose 4-epimerase
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
fast: false
reversible: true
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.2
is described by: ECO:0000134

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
boundary condition: false
initial concentration: 1.0
name: lipoamide
constant: false
is: HMDB00962
is: CHEBI:17460
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM arg L e
boundary condition: false
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
name: L-argininium(1+)
is: HMDB00517
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:32682

metaM ocdcea r
initial concentration: 1.0
is: SBO:0000247
is: C00712
is: HMDB00207
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
boundary condition: false
constant: false
name: octadecenoate (n-C18:1)
type: Species
is: CHEBI:0

metaM ptrc c
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
type: Species
is: C00134
initial amount: NaN
is: HMDB01414
name: Putrescine
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:326268

metaR O2ter
kinetic law: MODEL1310110040#
name: O2 transport, endoplasmic reticulum
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_dbc1a4fd_60fd_40a2_b007_c913cb884917
initial concentration: NaN
constant: false
initial amount: NaN
is: Q8IV97
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: SLC7A5
is encoded by: hsa:8140

metaM pmtcoa c
boundary condition: false
is: HMDB01338
initial concentration: 1.0
is: SBO:0000247
is: C00154
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaR C161CRN2t
product: MODEL1310110040#
name: C161 transport into the mitochondria
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
reversible: false
is: SBO:0000185

metaR r1553
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaM g2m8masn r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
notes: FORMULA: C82H137N2O65X CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: C05874
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM hs deg7 l
boundary condition: false
type: Species
has only substance units: false
name: heparan sulfate, degradation product 7
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial amount: NaN
is: HMDB06254
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR GULNDer
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#
fast: false
name: gulonate dehydrogenase, endoplasmic reticulum

metaR r1789
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_6822b602_d1b8_461b_92e0_ee41440fdf35
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AU149534_1_m
initial concentration: NaN
is encoded by: hsa:AU149534

http://identifiers.org/biomodels.db/MODEL1310110040#_c6307b37_6e8a_408a_b753_b6494dc80901
type: Species
is encoded by: hsa:5625
name: PRODH
is: O43272
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaM ksi deg5 l
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
name: keratan sulfate I, degradation product 5
is: HMDB00143
is: CHEBI:12936
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b366fd28_4fb8_4e75_9666_86b06562db25
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC17A4
is encoded by: hsa:10050
is: Q9Y2C5
is: SBO:0000252

metaM cdpdag hs c
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58332
name: CDP-diacylglycerol(2-)
type: Species
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078

http://identifiers.org/biomodels.db/MODEL1310110040#_bbbe7247_421d_4ccc_b200_725e16cfe0ef
initial concentration: NaN
constant: false
is: SBO:0000252
name: PDE9A
type: Species
initial amount: NaN
is encoded by: hsa:5152
has only substance units: false
boundary condition: true

metaR TETDECE1CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR MTHFD2
is version of: http://identifiers.org/ec-code/3.5.4.9
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD)
reversible: true

metaR PSP L
is described by: ECO:0000269
name: phosphoserine phosphatase (L-serine)
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.3.3
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
type: Reaction

metaM gua e
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN
is: SBO:0000247
is: CHEBI:16235
name: guanine
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaR r1552
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_de4bff2b_b02d_4f12_af55_d624d5ef79da
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: Q16878
name: CDO1
boundary condition: true
is encoded by: hsa:1036
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b3e68a7a_3b80_4e68_820d_b825a21d82f5
is encoded by: hsa:125965
initial concentration: NaN
has only substance units: false
name: COX6B2
is: SBO:0000252
constant: false
type: Species
is: Q6YFQ2
initial amount: NaN
boundary condition: true

metaR RBTt
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110040#
is described by: ECO:0000000
name: ribitol transport via passive diffusion
fast: false
reversible: false
product: MODEL1310110040#

metaM ump e
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
is: CHEBI:57865
name: UMP(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_5ec662c1_158f_4540_8cac_c133bf126a81
name: PLCB1
initial amount: NaN
is encoded by: hsa:23236
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM arg L c
boundary condition: false
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
is: CHEBI:32682
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: HMDB00517

metaR CARPEPT1tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM ptrc e
is: CHEBI:326268
is: HMDB01414
type: Species
boundary condition: false
initial amount: NaN
is: C00134
name: Putrescine
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247

metaR S6T1g
fast: false
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_c428ec56_2865_482c_baca_015c92405fa4
name: ST3GAL3
constant: false
is encoded by: hsa:6487
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaM hs deg6 l
boundary condition: false
is: HMDB06254
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
name: heparan sulfate, degradation product 6
initial concentration: 1.0
constant: false

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r1788
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false

metaR r0911
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000185
reversible: true
product: MODEL1310110040#

metaM gmp g
name: GMP(3-)
type: Species
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM ksi deg1 l
is: CHEBI:18287
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 1
type: Species
is: HMDB00174
notes: FORMULA: C241H383N17O209S12X CHARGE: -13

metaR AG13T16g
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
kinetic law: MODEL1310110040#

metaM dhf e
initial concentration: 1.0
is: CHEBI:57451
is: HMDB01056
boundary condition: false
name: dihydrofolate(2-)
type: Species
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR HOCDACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR CSNATer
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
is described by: ECO:0000254
kinetic law: MODEL1310110040#
type: Reaction
name: carnitine O-acetyltransferase, endolasmic reticulum
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7

metaR LNLCCPT2
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: carnitine transferase
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: false

metaM chsterol l
is: CHEBI:16113
initial concentration: 1.0
type: Species
name: cholesterol
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: HMDB00067
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8685790f_6cb0_4e0a_a517_8760ab0a1e8b
has only substance units: false
boundary condition: true
is encoded by: hsa:1854
type: Species
initial concentration: NaN
is: P33316
name: DUT
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_aa9a45e3_2e86_4740_ab67_aee72ae5dfe1
is: B5MCC7
is: SBO:0000252
name: ACP1
constant: false
is encoded by: hsa:52
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM ksi pre27 g
constant: false
boundary condition: false
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 27
is: HMDB00175
is: CHEBI:58053
is: C00130
is: SBO:0000247
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial concentration: 1.0
initial amount: NaN

metaM mercppyr c
is: SBO:0000247
is: CHEBI:57678
name: 3-mercaptopyruvate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: HMDB01368

metaR PRASCS
reversible: true
is: SBO:0000176
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110040#

metaR FATP3t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR RE3241R
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
name: RE3241
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110040#

metaM so4 c
is: SBO:0000247
is: CHEBI:16189
name: sulfate
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
is: HMDB01448
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_265bd819_ae68_4834_be2d_4645399a5601
has only substance units: false
initial amount: NaN
type: Species
name: SLC27A1
is: Q6PCB7
is encoded by: hsa:376497
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR GP1CALPHAtg
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110040#
name: gp1calpha hs intracellular transport
reversible: true
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185

metaM ump g
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB00288
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
initial amount: NaN
name: UMP(2-)

metaR r1554
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM ocdcea e
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
initial concentration: 1.0
type: Species
constant: false
name: octadecenoate (n-C18:1)
is: CHEBI:0
initial amount: NaN
is: HMDB00207
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2f847ce7_4ab5_42f7_8e83_ae243f287235
initial concentration: NaN
is encoded by: hsa:5130
type: Species
name: PCYT1A
is: P49585
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM gua c
constant: false
is: C00242
is: HMDB00132
name: Guanine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16235
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species

metaM b2coa m
is: CHEBI:57332
boundary condition: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: crotonoyl-CoA(4-)
is: SBO:0000247
is: HMDB02009

metaM octdececrn c
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
is: HMDB06351
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR NDP7er
reversible: false
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_5e6e1614_8e75_4a4b_bb64_1ea5e4a1b7ae
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2509
name: _2509_1_e
boundary condition: true
is: SBO:0000252

metaR DHFtm
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: dihydrofolate reversible mitochondrial transport
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true

metaM CE2417 m
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false

metaM prostge1 c
has only substance units: false
name: prostaglandin E1(1-)
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
is: CHEBI:57397
initial amount: NaN
is: HMDB01442

http://identifiers.org/biomodels.db/MODEL1310110040#_7069663c_b50d_4ef1_b02a_ff01669bd116
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFAB1
is: O14561
type: Species
initial concentration: NaN
is encoded by: hsa:4706
constant: false
initial amount: NaN

metaR G12MT2 L
reversible: false
type: Reaction
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110040#
reactant: MODEL1310110040#

metaR FAOXC200180m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110040#
name: Beta oxidation of long chain fatty acid
reversible: false
modifier: MODEL1310110040#
type: Reaction
is described by: ECO:0000000

metaM acald m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
type: Species
name: acetaldehyde
is: HMDB00990
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

metaR DHCR71r
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
name: 7-dehydrocholesterol reductase
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

metaM gmp e
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP(3-)
is: CHEBI:58115
constant: false
is: HMDB01397
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR DHFtl
is described by: ECO:0000000
type: Reaction
name: dihydrofolate reversible lysosomal transport
is: SBO:0000185
reactant: MODEL1310110040#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM chsterol e
name: cholesterol
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: HMDB00067
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_e4a533fc_b242_467f_943f_c649bc0c3790
is encoded by: hsa:6482
constant: false
has only substance units: false
name: ST3GAL1
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q11201

metaR DPCOAtl
type: Reaction
product: MODEL1310110040#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: dephospho-CoA transport from lysosome via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT

metaR C6COAt
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaM pac c
name: phenylacetate
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
is: CHEBI:18401
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaM so4 e
is: HMDB01448
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
has only substance units: false
initial concentration: 1.0

metaR LNLCCPT1
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110040#
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110040#
reversible: false
fast: false

metaR CHOLPtg
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
name: choline phosphate intracellular transport
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ

metaM aacoa m
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57286
is: HMDB01484
has only substance units: false
boundary condition: false
name: acetoacetyl-CoA(4-)

metaR r0915
fast: false
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR AG13T5g
modifier: MODEL1310110040#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110040#

metaR r2193
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110040#
reversible: true
fast: false
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_74e3bf85_3510_40fe_91c2_69b21e6210bd
constant: false
name: ATP5J2
is: SBO:0000252
is encoded by: hsa:9551
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: P56134

metaM prostge1 e
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: prostaglandin E1(1-)
type: Species
initial amount: NaN
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: HMDB01442

metaR r1551
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR SPMTDe
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110040#
name: SPMTDe
fast: false
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM crn m
is: HMDB00062
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
name: L-Carnitine
constant: false
is: CHEBI:16347
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM gmp c
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58115
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP
is: HMDB01397
boundary condition: false
is: C00144
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_735f8489_8fdd_4cf5_a10a_3c97c639f250
name: NDUFS8
initial concentration: NaN
is encoded by: hsa:4728
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: O00217

metaR ALAt2r
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
product: MODEL1310110040#
type: Reaction
name: L-alanine reversible transport via proton symport
fast: false
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185

metaR 10FTHFtm
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
fast: false

metaR HEX1
name: hexokinase (D-glucose:ATP)
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
modifier: MODEL1310110040#

metaR GCCcm
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoylprotein), mitochondrial
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2

metaR RE2349C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
reversible: true
name: RE2349
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
modifier: MODEL1310110040#
is: SBO:0000176

metaM amet m
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
is: C00019
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: S-Adenosyl-L-methionine
is: CHEBI:15414
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR CHOLD2m
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.99.1
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false
name: choline dehydrogenase (FAD acceptor), mitochondrial
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000269

metaR r2195
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110040#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM hs deg11 l
is: HMDB00868
is: SBO:0000247
initial amount: NaN
constant: false
name: heparan sulfate, degradation product 11
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
has only substance units: false
is: CHEBI:57737

metaR r0913
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR C4CRNCPT2
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaR FAOXTC182TC162m
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_32f1f944_a295_4679_89ed_1acc0bb8b3c2
is: F5H066
initial concentration: NaN
boundary condition: true
constant: false
name: SLC12A4
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6560
initial amount: NaN

metaM sphmyln hs c
boundary condition: false
initial amount: NaN
has only substance units: false
name: sphingomyelin betaine
is: CHEBI:58216
is: SBO:0000247
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
type: Species
constant: false
initial concentration: 1.0

metaR EX ebastineoh LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxylated ebastine exchange
type: Reaction

metaR THMDt4
kinetic law: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
reversible: false
fast: false
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: thymidine transport in via sodium symport

metaM btn m
type: Species
is: CHEBI:57586
is: SBO:0000247
is: HMDB00030
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN
constant: false
name: biotinate

metaM 3aib c
is: CHEBI:33094
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: HMDB02166
constant: false
is: SBO:0000247

metaM xol7ah2al c
is: CHEBI:27428
type: Species
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
has only substance units: false
is: HMDB06894
constant: false
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a0875943_19fc_4aaa_a223_91583f01f1b8
has only substance units: false
type: Species
is: SBO:0000252
is: Q7Z3X3
is encoded by: hsa:2799
initial amount: NaN
name: GNS
constant: false
boundary condition: true
initial concentration: NaN

metaR r2420
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false

metaR r2199
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000

metaR ATPtm
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110040#
modifier: MODEL1310110040#
name: ADP/ATP transporter, mitochondrial
reversible: false

metaR SLDx
type: Reaction
fast: false
is: SBO:0000176
name: L-sulfolactate dehydrogenase (NAD+)
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
is version of: http://identifiers.org/ec-code/1.1.1.37
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000304

metaM itacon m
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: CHEBI:17240
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB02092
name: itaconate(2-)
boundary condition: false

metaR RE2675C
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8560.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10722759,PMID:10880336,PMID:11937514,PMID:8449895 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
name: RE2675
reversible: false
fast: false
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_7be31213_6161_4feb_98b0_2910d8beae1e
type: Species
is encoded by: hsa:641372
is: Q3I5F7
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: ACOT6
boundary condition: true
initial amount: NaN

metaM pcrn m
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
constant: false
is: HMDB00824
name: propionyl-carnitine
type: Species

metaR LTA4H
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000134
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.3.2.6
name: Leukotriene A-4 hydrolase
kinetic law: MODEL1310110040#

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110040#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM nad x
is: HMDB00902
is: C00003
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57540
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide

metaR DGK2m
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reversible: true
is: SBO:0000176
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
fast: false

metaM HC01602 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:57454
is: C00234
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
has only substance units: false
name: 10-Formyltetrahydrofolate

metaM dhlam m
constant: false
type: Species
boundary condition: false
has only substance units: false
is: HMDB00985
is: CHEBI:17694
name: dihydrolipoamide
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579

metaM glyc R c
boundary condition: false
is: CHEBI:16659
is: SBO:0000247
name: D-glycerate
is: HMDB00139
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
type: Species

metaR r1109
type: Reaction
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6

metaR PROSTGE2t2
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
reversible: true
reactant: MODEL1310110040#
is: SBO:0000185
name: prostaglandin uniport
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_897335bf_eb01_43c2_a76e_b9aad5842929
initial amount: NaN
is encoded by: hsa:2678
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GGT1
is: P19440
initial concentration: NaN

metaR RE3006M
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110040#
name: RE3006
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM gthrd m
name: glutathionate(1-)
is: HMDB00125
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaR EX c4dc
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaR ORNt3m
fast: false
reactant: MODEL1310110040#
reversible: true
name: ornithine mitochondrial transport via proton antiport
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000185

metaM ksii core2 pre4 g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C53H86N4O38X CHARGE: -1
constant: false
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
type: Species
has only substance units: false
is: CHEBI:58053
boundary condition: false
is: HMDB00175

metaR r2197
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR NODe
reactant: MODEL1310110040#
name: NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR LINKDEG4ly
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

metaR UAGDP
is version of: http://identifiers.org/ec-code/2.7.7.23
kinetic law: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110040#
product: MODEL1310110040#
name: UDP-N-acetylglucosamine diphosphorylase
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_cdee0882_77d9_40f0_8ee6_1b80c2a9471f
name: ACADL
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P28330
type: Species
constant: false
has only substance units: false
is encoded by: hsa:33
initial concentration: NaN

metaM thf m
is: CHEBI:57453
boundary condition: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
initial amount: NaN
is: HMDB01846
type: Species
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
is: C00101
is: SBO:0000247

metaR BACCL
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
modifier: MODEL1310110040#
is: SBO:0000176
name: biotin-[acetyl-CoA-carboxylase] ligase
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction

metaR C4STMO2Pr
fast: false
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
name: C-4 methyl sterol oxidase
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.170

metaM 3aib e
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02166
initial amount: NaN
is: CHEBI:33094
name: (S)-3-aminoisobutyric acid
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
initial concentration: 1.0
boundary condition: false

metaM xol7ah2 c
boundary condition: false
is: CHEBI:28047
is: HMDB06893
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha-diol
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_36c7ee2f_baf8_413d_8a8c_6a32d5d45f90
name: ECHS1
is encoded by: hsa:1892
constant: false
initial concentration: NaN
boundary condition: true
is: P30084
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r2196
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is: SBO:0000185
modifier: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaR THRD L
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.3.1.17
is described by: ECO:0000269
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
name: L-threonine deaminase
reversible: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_edefe91e_f9f9_4713_8d64_0836956cfa66
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: P49902
is encoded by: hsa:22978
type: Species
name: NT5C2

http://identifiers.org/biomodels.db/MODEL1310110040#_09c57c49_2b26_4add_8a68_215145bf4ae4
name: SLC25A1
is encoded by: hsa:6576
is: SBO:0000252
initial concentration: NaN
is: D9HTE9
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaR DM atp c
reversible: false
name: DM_atp(c)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#

metaM ppi x
is: HMDB00250
constant: false
is: CHEBI:33019
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: C00013
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
name: Diphosphate

http://identifiers.org/biomodels.db/MODEL1310110040#_fc061cb8_99f2_4477_bc57_bc0470d4fef3
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: Q92523
type: Species
has only substance units: false
is encoded by: hsa:1375
name: CPT1B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_0a91b84b_72d7_477d_b6e1_878bb9009d3b
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4190
is: B7Z3I7
type: Species
name: MDH1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_70a54f73_f61b_4acf_bfd4_3c0b57dc37a6
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:50
is: Q99798
name: ACO2
initial amount: NaN

metaR FAOXC121C10x
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR FAOXC10C8x
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR NNATn
name: nicotinate-nucleotide adenylyltransferase
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.18 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:12574164 NOTES:IT
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110040#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000269
fast: false
product: MODEL1310110040#

metaR FAOXC14C14OHm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaM glypro e
name: Glycylproline
is: HMDB00721
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C7H12N2O3 CHARGE: 0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/79101

http://identifiers.org/biomodels.db/MODEL1310110040#_51123cad_e996_4ce0_bafb_8bc6a1c392af
has only substance units: false
constant: false
name: GGT5
initial amount: NaN
is encoded by: hsa:2687
is: SBO:0000252
is: P36269
initial concentration: NaN
type: Species
boundary condition: true

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_357575f6_7eee_4f7f_8c28_ddd92698b356
is: SBO:0000252
is encoded by: hsa:8867
boundary condition: true
constant: false
is: C9JFZ1
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SYNJ1

metaR O2tm
name: O2 transport (diffusion)
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
is described by: ECO:0000000
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000185
fast: false

metaR r0170
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
product: MODEL1310110040#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

http://identifiers.org/biomodels.db/MODEL1310110040#_62620595_5521_43aa_98c2_ebe419b8fab3
is encoded by: hsa:51079
is: Q9P0J0
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFA13
is: SBO:0000252
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0157d84b_6e2b_4ab4_873a_e6dd18df0080
type: Species
boundary condition: true
is encoded by: hsa:1384
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CRAT
constant: false
initial concentration: NaN

metaR C2tcx
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_5b00f0e1_2040_46ae_bef7_b3def54b07d4
has only substance units: false
name: SLC38A1
is: Q9H2H9
is encoded by: hsa:81539
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaM gam e
is: CHEBI:17315
is: C00329
boundary condition: false
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: D-Glucosamine
initial amount: NaN
is: HMDB01514

http://identifiers.org/biomodels.db/MODEL1310110040#_64ef50b3_3443_4529_b672_b576161e1757
has only substance units: false
is encoded by: hsa:130752
initial concentration: NaN
constant: false
initial amount: NaN
name: MDH1B
is: Q5I0G3
boundary condition: true
is: SBO:0000252
type: Species

metaR FAOXC14C12x
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_37edfc4a_d0df_4858_b496_a9cbf2af15c9
boundary condition: true
is encoded by: hsa:8818
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: DPM2
is: O94777
type: Species
has only substance units: false

metaR TMNDNCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
reversible: false
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
type: Reaction

metaM 5htrp c
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: HMDB00472
is: CHEBI:17780
boundary condition: false
type: Species
name: 5-hydroxy-L-tryptophan
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM c10dc c
constant: false
is: HMDB00651
name: sebacoyl carnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H30NO6 CHARGE: -1
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7bc495d7_cf91_4928_99eb_3db5dd142d9b
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q07973
is: SBO:0000252
initial concentration: NaN
name: CYP24A1
is encoded by: hsa:1591
has only substance units: false

metaM pmtcoa x
type: Species
constant: false
is: C00154
is: CHEBI:57379
is: HMDB01338
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
boundary condition: false
initial amount: NaN

metaR HEX10
modifier: MODEL1310110040#
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000212
product: MODEL1310110040#
reactant: MODEL1310110040#

metaR LTD4DP
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
name: Leukotriene D4 dipeptidase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_e95c4050_cc7f_44c7_924b_9cd8eab6fd29
name: MAN2A2
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4122
is: Q9P1E4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_aaa7797a_a07d_46a6_acb4_8899fb521d1a
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:AA081045
name: _AA081045_1_c
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_b0a5be56_f47b_497a_ae20_d4aa2145f67a
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5322
name: PLA2G5
is: SBO:0000252
type: Species
is: P39877
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9a367495_fff8_433c_b7ab_f53035cff509
is encoded by: hsa:5091
has only substance units: false
name: PC
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: P11498

metaM lanost r
is: SBO:0000247
is: HMDB01251
name: lanosterol
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial amount: NaN
is: CHEBI:16521
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4ff2aef2_b444_4716_afa6_0688b0403a8f
constant: false
initial amount: NaN
is: Q9H845
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:28976
name: ACAD9
boundary condition: true

metaM HC00664 c
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58695
type: Species
name: D-tagatofuranose 6-phosphate(2-)
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_071bde64_b256_4105_af7b_acae736fdd1a
is: Q9H0N5
initial amount: NaN
type: Species
name: PCBD2
is encoded by: hsa:84105
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR GALASE13ly
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM dhf c
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
is: C00415
type: Species
name: 7,8-Dihydrofolate
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01056
is: CHEBI:57451
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_68cca410_f7dc_497a_a02f_ed92abb4cc05
type: Species
is encoded by: hsa:8879
is: O95470
is: SBO:0000252
name: SGPL1
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaM HC01609 e
constant: false
boundary condition: false
is: CHEBI:28766
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
has only substance units: false
name: UroporphyrinogenI
type: Species

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR r2007
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
reversible: false
is: SBO:0000185
product: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_3312a9df_beac_4aae_bce4_6196db30602d
initial amount: NaN
is encoded by: hsa:8622
type: Species
is: O95263
boundary condition: true
is: SBO:0000252
name: PDE8B
constant: false
initial concentration: NaN
has only substance units: false

metaR ATPtn
reactant: MODEL1310110040#
name: ATP diffusion in nucleus
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110040#

metaM gacpail hs c
initial amount: NaN
is: HMDB01401
has only substance units: false
constant: false
is: C00092
is: CHEBI:61548
name: glucosaminyl-acylphosphatidylinositol
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM btn e
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
name: Biotin
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00030
has only substance units: false
is: C00120

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaM nad n
is: HMDB00902
is: CHEBI:57540
initial concentration: 1.0
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
name: NAD(1-)

metaR 3HKYNAKGAT
kinetic law: MODEL1310110040#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.6.1.64
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is: SBO:0000176
fast: false
product: MODEL1310110040#
type: Reaction
reversible: false
modifier: MODEL1310110040#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

metaR UMPK6
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
name: UMP kinase (dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_7fc20629_c01d_464d_9544_8963a7bc2989
type: Species
constant: false
is: SBO:0000252
is: O14735
is encoded by: hsa:10423
name: CDIPT
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM 2mp2coa m
type: Species
boundary condition: false
is: SBO:0000247
name: 2-Methylprop-2-enoyl-CoA
constant: false
initial concentration: 1.0
is: CHEBI:27754
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial amount: NaN
is: HMDB01011
has only substance units: false

metaM pmtcoa r
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: CHEBI:3454
type: Species
constant: false
is: HMDB01338
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_ace25a19_72e6_49c8_b31b_a106b5fbb383
initial amount: NaN
boundary condition: true
is encoded by: hsa:221
name: ALDH3B1
initial concentration: NaN
is: P43353
constant: false
type: Species
is: SBO:0000252
has only substance units: false

metaR RE2972M
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE2972
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reversible: true
reactant: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.67

metaR O2tp
kinetic law: MODEL1310110040#
name: O2 transport, peroxisomal
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_ee721421_dcde_425f_916a_ac6256425602
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: PPAP2A
is encoded by: hsa:8611
is: G3XA95

metaR GALASE6ly
type: Reaction
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110040#_ab3261b3_29e4_4710_a47d_e36c3dc359e8
name: CHAT
initial amount: NaN
is encoded by: hsa:1103
initial concentration: NaN
is: D3DX95
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM ppi r
initial concentration: 1.0
name: Diphosphate
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00013
is: CHEBI:33019
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_45c6cc17_1aa8_498a_9dde_98cbcf35715c
type: Species
name: _AD000092_1_c
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AD000092
boundary condition: true
initial amount: NaN

metaR UMPK5
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: UMP kinase (dATP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176

metaR S6TASE18ly
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#

metaM gthrd e
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: glutathionate(1-)
initial concentration: 1.0
is: CHEBI:57925
type: Species
has only substance units: false

metaM 3pg c
is: SBO:0000247
boundary condition: false
is: HMDB00807
has only substance units: false
type: Species
constant: false
name: 3-Phospho-D-glycerate
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:58272
is: C00197

metaM ksii core4 deg1 l
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
is: HMDB00868
is: CHEBI:57737
name: keratan sulfate II (core 4-linked), degradation product 1
has only substance units: false
type: Species
initial concentration: 1.0

metaR CSPG Atly
reactant: MODEL1310110040#
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
reversible: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185

metaR GCHOLAtx
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaR DNDPt46m
reversible: false
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
type: Reaction
modifier: MODEL1310110040#
name: dTTP transport via dUDP antiport
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110040#

metaM thf e
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
initial concentration: 1.0
constant: false
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01846
type: Species
has only substance units: false

metaM 3aib m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02166
type: Species
has only substance units: false
constant: false
name: (S)-3-aminoisobutyric acid
initial amount: NaN

metaM glypro c
initial concentration: 1.0
is: HMDB00721
boundary condition: false
name: Glycylproline
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/79101
is: SBO:0000247
notes: FORMULA: C7H12N2O3 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_7dc91c08_ad49_4f91_bfdf_b22712cdb147
boundary condition: true
constant: false
name: OGDH
has only substance units: false
is encoded by: hsa:4967
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q02218

metaR r0173
reversible: true
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.19
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_08e029a5_18fc_4dcc_8ce5_58b7a310e989
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:291
name: SLC25A4
constant: false
is: P12235
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_38dac62d_0fb6_42a2_b684_9c29edddc232
boundary condition: true
is: O75521
constant: false
is encoded by: hsa:10455
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ECI2
has only substance units: false

metaR OLEICFATPtc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM pe hs r
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:16038

metaR UMPK7
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
name: UMP kinase (dGTP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM octa e
is: HMDB00482
has only substance units: false
is: C06423
is: CHEBI:25646
initial concentration: 1.0
boundary condition: false
name: octanoate (n-C8:0)
notes: FORMULA: C8H15O2 CHARGE: -1
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

metaM nad m
is: HMDB00902
name: Nicotinamide adenine dinucleotide
has only substance units: false
constant: false
is: SBO:0000247
is: C00003
is: http://identifiers.org/pubchem.compound/3305
type: Species
initial concentration: 1.0
is: CHEBI:57540
initial amount: NaN
boundary condition: false

metaR RE3566C
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE3566
product: MODEL1310110040#

metaM m6masnC g
type: Species
initial amount: NaN
is: SBO:0000247
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:50570
is: HMDB06529

metaR OCD11CRNCPT2
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM mi13p c
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:18225
name: 1D-myo-Inositol 1,3-bisphosphate
initial concentration: 1.0
is: HMDB06234
constant: false
type: Species

metaM gthrd c
name: Reduced glutathione
is: C00051
constant: false
is: SBO:0000247
is: HMDB00125
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
boundary condition: false
is: CHEBI:57925

metaR MM7Cbg
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
reversible: false

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110040#
reversible: true
fast: false
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR C4STMO2r
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
modifier: MODEL1310110040#
name: C-4 methyl sterol oxidase
is version of: http://identifiers.org/ec-code/1.1.1.170
is version of: http://identifiers.org/ec-code/1.14.13.72
fast: false
product: MODEL1310110040#
type: Reaction

metaR GALASE16ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR CYTK13n
fast: false
is: SBO:0000176
name: cytidylate kinase (dCMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR SLDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: L-sulfolactate transport (cytosol to extracellular)
kinetic law: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8021c0dd_a987_4625_ba7c_959d485bf127
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:622
initial amount: NaN
initial concentration: NaN
name: BDH1
constant: false
has only substance units: false

metaM nad r
is: HMDB00902
is: CHEBI:57540
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: NAD(1-)
is: SBO:0000247
type: Species
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003

metaR TRIODTHYt2
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
name: T3 transport via facilitated diffusion

metaR GLCAASE7ly
type: Reaction
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
is: SBO:0000176
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110040#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR r0179
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110040#

metaM ac e
is: HMDB00042
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: acetate
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2ce0c255_bebc_49ab_aa79_b84fde687ba5
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:4716
initial concentration: NaN
is: A8K761
name: NDUFB10
initial amount: NaN
has only substance units: false

metaR r1691
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110040#

metaR RE1834C
kinetic law: MODEL1310110040#
name: RE1834
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10817395,PMID:10944470,PMID:11454857,PMID:11673457 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
fast: false

metaM spmd c
boundary condition: false
is: SBO:0000247
constant: false
name: Spermidine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: HMDB01257
type: Species
is: C00315
is: CHEBI:57834

metaM octa c
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: C06423
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
name: octanoate (n-C8:0)
is: CHEBI:25646
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d2f1c216_c566_4226_8e9f_ffce1bdf354f
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _H53099_1_m
initial concentration: NaN
is encoded by: hsa:H53099
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_d7f00778_0f2c_42b4_8b1f_8e36e180b4da
is encoded by: hsa:80339
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: PNPLA3
is: Q9NST1

http://identifiers.org/biomodels.db/MODEL1310110040#_b1bdef69_d82d_4a4d_9705_ebe546d1f64b
constant: false
type: Species
is encoded by: hsa:516
initial amount: NaN
name: ATP5G1
is: Q6FIH7
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r0178
fast: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_2b6856bc_a47a_4d13_b3a9_0b9237febb01
is: SBO:0000252
is encoded by: hsa:1375
initial concentration: NaN
is: E9PCP2
name: CPT1B
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM HC00591 c
boundary condition: false
initial concentration: 1.0
name: 2-oxoglutaramate
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
type: Species

metaM guln r
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
type: Species
is: CHEBI:13115
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: L-gulonate
is: HMDB03290
has only substance units: false

metaM HC00822 l
boundary condition: false
has only substance units: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
type: Species
is: CHEBI:28681
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: Chitobiose
constant: false

metaR UMPK4
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
name: UMP kinase (GTP)
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_8c9c6305_a326_4ff2_bd04_c3c52344b80b
is: P30838
is encoded by: hsa:218
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: ALDH3A1

metaR r1106
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110040#

metaR GUAD
is version of: http://identifiers.org/ec-code/3.5.4.3
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
name: guanine deaminase
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (9615.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_28d2a253_b23e_4472_91d9_966ae22d6a98
boundary condition: true
is: P30566
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: ADSL
has only substance units: false
constant: false
is encoded by: hsa:158

metaM pcrn c
boundary condition: false
is: http://identifiers.org/pubchem.compound/107738
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
is: HMDB00824
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: propionyl-carnitine

metaM 10fthf6glu e
has only substance units: false
is: CHEBI:57454
initial concentration: 1.0
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
is: HMDB00972
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

metaR NACHEX21ly
type: Reaction
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: false
product: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR ATPtx
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
name: ATP transporter, peroxisomal
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_467febe0_4b50_4ce5_8bd3_8772ab3d92a1
initial amount: NaN
constant: false
is encoded by: hsa:5019
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: OXCT1
has only substance units: false
type: Species
is: P55809

metaM ac c
is: HMDB00042
is: CHEBI:30089
is: SBO:0000247
type: Species
name: acetate
initial concentration: 1.0
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
boundary condition: false
has only substance units: false

metaR MI14P4P
product: MODEL1310110040#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: inositol-1,4-bisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
is described by: ECO:0000000

metaM gq1c hs g
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:28058
has only substance units: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247
name: GQ1c

http://identifiers.org/biomodels.db/MODEL1310110040#_bd0c442f_3698_4b4c_b35a_6b1793dc2707
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AA676725
name: _AA676725_1_c

metaM xol7ah2al m
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
is: CHEBI:27428
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
is: HMDB06894
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaM spmd e
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01257
name: Spermidine
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: C00315
is: CHEBI:57834

metaR UMPK3
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
name: UMP kinase (UTP)
reversible: true
modifier: MODEL1310110040#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_49b043d4_6950_4e5e_9eb8_bd28dda6a936
has only substance units: false
type: Species
is encoded by: hsa:6901
boundary condition: true
is: Q16635
name: TAZ
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaM ksii core2 pre2 g
is: HMDB00175
notes: FORMULA: C39H63N3O28X CHARGE: -1
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
constant: false
is: C00130
name: keratan sulfate II biosynthesis, precursor 2

metaR r1690
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b4b50886_6798_43ca_929d_1f568493183b
constant: false
name: RDH14
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:57665
is: Q9HBH5
initial concentration: NaN
type: Species

metaR KCC2t
fast: false
reversible: true
name: K+-Cl- cotransporter (NH4+)
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110040#

metaR UMPK2
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: UMP kinase (CTP)
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaM dgtp n
is: C00286
constant: false
initial amount: NaN
type: Species
is: HMDB01440
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: dGTP
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

http://identifiers.org/biomodels.db/MODEL1310110040#_d660ca88_106f_4b64_8e55_a807dd38bc86
is: D3DWC4
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SGMS1
initial amount: NaN
is encoded by: hsa:259230
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_52effa38_40a0_4d76_8ca3_0f9897839825
is encoded by: hsa:29929
initial concentration: NaN
type: Species
has only substance units: false
name: ALG6
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is: Q9Y672

metaM 4abutn m
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
initial concentration: 1.0
is: HMDB01080
name: 4-ammoniobutanal
type: Species
is: CHEBI:58264
constant: false
has only substance units: false

metaR ARACHCRNt
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
type: Reaction
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000185

metaR DHPR2
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
name: 6,7-dihydropteridine reduction
is: SBO:0000176
is described by: ECO:0000304
fast: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM dsmsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
initial concentration: 1.0
is: HMDB02719
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: desmosterol
is: CHEBI:17737
constant: false
is: SBO:0000247

metaM c10dc x
notes: FORMULA: C17H30NO6 CHARGE: -1
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB00651
name: sebacoyl carnitine
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_b0c79011_0f39_41fa_9824_71f125a8c502
is encoded by: hsa:55
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ACPP
boundary condition: true
constant: false
is: P15309

metaM dgtp m
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
initial amount: NaN
is: CHEBI:16497
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB01440
is: C00286
name: dGTP

metaR AG13T4g
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110040#_2f25dec1_7f09_4d16_8087_6790a0ba9d6d
type: Species
is encoded by: hsa:6799
is: SBO:0000252
has only substance units: false
constant: false
name: SULT1A2
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR FAOXC8C6x
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

metaM 2oxoadp m
boundary condition: false
initial concentration: 1.0
is: CHEBI:57499
name: 2-oxoadipate(2-)
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00225
has only substance units: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaR G14T13g
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM 2dr1p c
type: Species
is: HMDB01351
boundary condition: false
has only substance units: false
is: C00672
constant: false
is: CHEBI:58576
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672

metaM HC00229 e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: Isomaltose
boundary condition: false
is: CHEBI:28189
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false

metaR r0817
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
product: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_e6e3662e_a231_4211_a3de_04b9adf1a987
initial concentration: NaN
is encoded by: hsa:124454
constant: false
has only substance units: false
is: Q5JPH6
type: Species
boundary condition: true
name: EARS2
is: SBO:0000252
initial amount: NaN

metaR ASPGLUm
product: MODEL1310110040#
modifier: MODEL1310110040#
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_7da26d95_fb3c_4cfc_9cef_912dc096bbb9
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AL050025
is: SBO:0000252
name: _AL050025_1_c
constant: false
initial amount: NaN
has only substance units: false

metaR r1549
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110040#

metaM CE5161 r
is: CHEBI:15748
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00127
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA

metaM cs a l
boundary condition: false
is: CHEBI:36005
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: SBO:0000247
is: HMDB02183
type: Species
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
constant: false

metaR BALAtmr
type: Reaction
reversible: true
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_f2fdeea3_b3e8_45a3_8754_09bf292ec158
boundary condition: true
is: P05177
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1544
name: CYP1A2

metaR ANTHte
is: SBO:0000185
reactant: MODEL1310110040#
type: Reaction
fast: false
reversible: true
name: Transport of anthranilate
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaM cys L e
is: HMDB00574
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: L-cysteine
initial amount: NaN
is: CHEBI:17561

http://identifiers.org/biomodels.db/MODEL1310110040#_6b20eb81_c8ae_40b1_9fab_71adb52e069a
initial amount: NaN
type: Species
is encoded by: hsa:8613
constant: false
is: O14495
name: PPAP2B
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM hs deg8 l
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:16126
initial concentration: 1.0
name: heparan sulfate, degradation product 8
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: SBO:0000247
constant: false

metaR RE0912C
is: SBO:0000176
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
name: RE0912
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (25830.1) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10199779,PMID:11397879,PMID:12039030,PMID:8767510,PMID:9463486 NOTES:
type: Reaction
reversible: false

metaR r1548
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false

metaR r0819
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_87c68520_6fc7_4428_a52f_d3fa659b1ba2
initial concentration: NaN
type: Species
is encoded by: hsa:158
has only substance units: false
name: ADSL
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM man1p c
type: Species
initial concentration: 1.0
initial amount: NaN
name: D-Mannose 1-phosphate
is: CHEBI:35374
is: HMDB06330
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_34b02896_b040_4b93_81cc_3dc68c290e58
initial concentration: NaN
is encoded by: hsa:53354
initial amount: NaN
name: PANK1
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is: Q8TE04
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_f2190439_205a_404a_a2b3_28242bfbe385
initial amount: NaN
name: GALNT1
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q10472
has only substance units: false
constant: false
is encoded by: hsa:2589

metaR r1547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000185

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
name: diphosphate(3-)
type: Species
has only substance units: false
is: CHEBI:33019
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110040#_fa586cc7_dde9_48b2_a32d_b7fc2dc88adb
is encoded by: hsa:83549
type: Species
initial concentration: NaN
is: SBO:0000252
name: UCK1
is: Q5JT09
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4bbd0429_ae6f_4d90_9c4f_ef2d4581e582
type: Species
is: O14986
is encoded by: hsa:8395
has only substance units: false
name: PIP5K1B
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_7da1ee92_f30a_4303_a1b7_e38b985b12b6
initial concentration: NaN
name: SGPP2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:130367
constant: false
boundary condition: true
is: Q8IWX5
has only substance units: false

metaR r0812
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
is described by: ECO:0000000
modifier: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_3abc60f9_6cfd_4b09_9adf_0d6384f26d0c
name: RDH5
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5959
initial amount: NaN
type: Species
is: SBO:0000252
is: Q92781
has only substance units: false

metaR LPS2
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.1.34
name: lipase
is: SBO:0000176
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
is described by: ECO:0000000
fast: false

metaM thf c
is: C00101
is: CHEBI:57453
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial concentration: 1.0
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
constant: false

metaM ppi m
has only substance units: false
is: C00013
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: CHEBI:33019
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00250
name: Diphosphate
initial concentration: 1.0

metaR r1546
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_61488cf7_0b75_422e_bb0a_d5255c1e10b4
initial amount: NaN
type: Species
constant: false
is: P29803
initial concentration: NaN
name: PDHA2
has only substance units: false
is encoded by: hsa:5161
is: SBO:0000252
boundary condition: true

metaM ac m
name: acetate
has only substance units: false
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00042

metaM his L m
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
is: CHEBI:15971
boundary condition: false
initial concentration: 1.0
is: HMDB00177

metaR NRPPHRSFt
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: norepinephrine sulfate transport (diffusion)
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
fast: false
is: SBO:0000185

metaR r0813
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
reversible: false
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9

metaR MEVK1x
reactant: MODEL1310110040#
name: mevalonate kinase (atp)
product: MODEL1310110040#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
is version of: http://identifiers.org/ec-code/2.7.1.36
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000134

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR LPS3
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.1.23
name: lipase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
modifier: MODEL1310110040#
reversible: false

metaM HC00822 e
type: Species
boundary condition: false
is: CHEBI:28681
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Chitobiose
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

metaR HOCTDECCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_28ad58b1_7b04_4180_8667_e91fadee1780
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: COX2
is encoded by: hsa:4513
is: Q7GXZ8

metaR IDOAASE1ly
is described by: ECO:0000000
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_5061abee_16a9_4358_889f_b456a2934bad
name: SLC7A6
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q92536
initial concentration: NaN
is encoded by: hsa:9057
is: SBO:0000252
boundary condition: true

metaR ARACHDtr
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a0831aa2_23bf_4842_9f78_0aed6fbbc37c
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _AI620219_1_m
is encoded by: hsa:AI620219
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_e905ba59_33bc_44f2_a0c9_691b250a10e8
initial amount: NaN
is encoded by: hsa:1340
boundary condition: true
is: P14854
has only substance units: false
name: COX6B1
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_8bce9790_2328_4d82_8783_1d8f9222b54a
is encoded by: hsa:4842
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: NOS1
is: B4DG68
initial concentration: NaN
constant: false
type: Species

metaM HC02179 e
boundary condition: false
is: CHEBI:34306
initial amount: NaN
is: SBO:0000247
name: 20-hydroxy-arachidonate
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

http://identifiers.org/biomodels.db/MODEL1310110040#_a98ce2e8_13e3_421e_ae25_37ae431cc1ef
has only substance units: false
name: HSD17B10
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3028
is: Q99714

http://identifiers.org/biomodels.db/MODEL1310110040#_0aac03f3_a770_41d3_9a3c_e83765110fa1
initial amount: NaN
constant: false
boundary condition: true
is: Q86YW0
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:89869
is: SBO:0000252
name: PLCZ1

http://identifiers.org/biomodels.db/MODEL1310110040#_25c35156_a04c_4655_9f97_12f28947898f
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: GCNT4
is encoded by: hsa:51301
is: Q9P109
has only substance units: false
initial concentration: NaN

metaM c81crn c
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: octenoyl carnitine
is: HMDB13324
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN
constant: false

metaR r1544
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_d0445a33_e73f_4048_bcc0_01c88c284e4b
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:6715
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P18405
name: SRD5A1

metaM 2oxoadp c
initial amount: NaN
name: 2-oxoadipate(2-)
constant: false
is: CHEBI:57499
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247
is: HMDB00225

http://identifiers.org/biomodels.db/MODEL1310110040#_4641c123_06e0_4e57_8c10_f0eea11501ef
is: SBO:0000252
is encoded by: hsa:284129
type: Species
initial concentration: NaN
has only substance units: false
is: Q86WA9
name: SLC26A11
initial amount: NaN
boundary condition: true
constant: false

metaR r1799
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
name: Y+LAT2 Utilized transport

metaR DNDPt15m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
name: dUDP transport via dGDP antiport
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
fast: false
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#

metaM g2m8mpdol L r
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
type: Species
is: C05870
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ba23f436_960b_40d4_add1_967f0bd3c5b1
name: _MBOAT5_1_c
is encoded by: hsa:MBOAT5
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR MANt1r
is described by: ECO:0000269
name: mannose transport (uniport)
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
modifier: MODEL1310110040#

metaM c81crn e
initial amount: NaN
is: HMDB13324
has only substance units: false
name: octenoyl carnitine
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C15H27NO4 CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_9359ff6e_a438_4e8c_973c_ae8cb98e0bbc
is encoded by: hsa:2974
type: Species
name: GUCY1B2:GUCY1A3
has part: D6RDW3
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:2982
boundary condition: true

metaR ACCOALm
product: MODEL1310110040#
is: SBO:0000176
reversible: false
fast: false
name: acetate-CoA ligase (AMP-forming)
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.1

metaR r1798
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_2584448d_a8d8_477c_898a_04cb81d2d285
is: E7EPT3
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:501
type: Species
name: ALDH7A1
initial amount: NaN
is: SBO:0000252

metaM hs deg4 l
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
name: heparan sulfate, degradation product 4
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
is: CHEBI:16126

metaR r0921
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
product: MODEL1310110040#
name: Postulated transport reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_199fafe3_4b18_4b85_8d9b_3d61916520dc
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: NME7
is: SBO:0000252
type: Species
is encoded by: hsa:29922

metaR TMDK1
is described by: ECO:0000269
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.21
fast: false
name: thymidine kinase (ATP:thymidine)
reversible: false

metaR ACTLMO
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1571.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:stoichiometry described in Thornalley PJ. Gen Pharmacol. 1996 Jun;27(4):565-73. PMID: 8853285 NCD
modifier: MODEL1310110040#
reversible: false
name: acetol monooxygenase
is: SBO:0000176
is described by: ECO:0000269
fast: false
reactant: MODEL1310110040#

metaM ksii core2 deg3 l
name: keratan sulfate II (core 2-linked), degradation product 3
initial concentration: 1.0
type: Species
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR AG13T15g
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110040#

metaR GPDDA1
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)

metaR LPCHOLt
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
name: lysophosphatidylcholine transport
type: Reaction
is: SBO:0000185
product: MODEL1310110040#

metaM thmpp m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial amount: NaN
constant: false
is: CHEBI:45931
is: HMDB01372
type: Species
boundary condition: false
name: Thiamine diphosphate

metaR PI4PLC
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110040#
name: phosphatidylinositol 4-phosphate phospholipase C
fast: false

metaM gpi sig r
is: CHEBI:58190
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
constant: false
is: HMDB00224
initial amount: NaN
has only substance units: false

metaR r1540
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185
reactant: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_b90b03a0_36b4_4ce2_a304_d33f7c387e9a
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: SULT1A1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6817

metaM glyc3p c
is: SBO:0000247
is: CHEBI:57597
name: Glycerol 3-phosphate
constant: false
is: C00093
boundary condition: false
initial amount: NaN
is: HMDB00126
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

http://identifiers.org/biomodels.db/MODEL1310110040#_4f037f86_ae3a_47ef_879c_992717b5843f
type: Species
initial concentration: NaN
constant: false
name: HEXA
has only substance units: false
is encoded by: hsa:3073
is: P06865
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR ACCOAtr
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000
name: acetyl-coa transport
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_4d087407_ecc0_48ac_b5fa_f28a21027e5e
type: Species
is: Q10471
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: GALNT2
initial concentration: NaN
constant: false
is encoded by: hsa:2590

metaM ksi deg2 l
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: CHEBI:50570
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB06529
name: keratan sulfate I, degradation product 2
boundary condition: false

metaR DOPAt4 2 r
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true

metaR S6TASE17ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_77370b99_8e88_496d_b6df_83d0ab6db996
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ACAD9
constant: false
is: Q9H845
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:28976

metaR DECDICRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaM pcrn x
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
is: HMDB00824

http://identifiers.org/biomodels.db/MODEL1310110040#_842edd1a_bdef_467e_bef6_825476e9ae7a
initial amount: NaN
constant: false
is encoded by: hsa:AI539321
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110040#_168ab249_1f41_4a02_8609_969713480ad8
type: Species
is: Q9HCS2
constant: false
is encoded by: hsa:66002
initial concentration: NaN
name: CYP4F12
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_4f654cf4_5bc8_432c_910a_39ab88a52c08
initial amount: NaN
constant: false
is: Q14642
is encoded by: hsa:3632
name: INPP5A
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaR SMPD3g
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is version of: http://identifiers.org/ec-code/3.1.4.12
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false

metaM focytC m
is: SBO:0000247
is: CHEBI:16928
name: Ferrocytochrome C
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
type: Species

metaM crvnc e
has only substance units: false
is: HMDB02183
initial concentration: 1.0
boundary condition: false
name: cervonic acid, C22:6 n-3
initial amount: NaN
notes: FORMULA: C22H31O2 CHARGE: -1
is: CHEBI:36005
is: SBO:0000247
constant: false
type: Species

metaM 4hglusa m
is: CHEBI:27809
is: HMDB06556
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: L-4-hydroxyglutamic semialdehyde

metaM biocyt e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
is: C05552
is: SBO:0000247
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886

metaR CHOLESTle
reactant: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.1.13
is: SBO:0000176
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
is described by: ECO:0000134
name: hydrolysis of cholesterol ester by cholesterol esterase
kinetic law: MODEL1310110040#
fast: false

metaM nad c
name: Nicotinamide adenine dinucleotide
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
is: C00003
constant: false
has only substance units: false
is: CHEBI:57540

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR EX c51crn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM ksi deg3 l
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: HMDB06529
is: CHEBI:50570
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 3
boundary condition: false
initial amount: NaN

metaM xoltriol c
has only substance units: false
is: CHEBI:16496
type: Species
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR GALt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110040#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: galactose transport via sodium symport

metaR LEUKTRF4t
reversible: true
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
name: leukotriene F4 transport
reactant: MODEL1310110040#
is: SBO:0000185

metaM g1m8mpdol L r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
initial concentration: 1.0
constant: false
is: C05870
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM mev R c
is: HMDB00227
name: (R)-mevalonate
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false
is: CHEBI:36464
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_65006a0c_8379_40ea_b4a6_202a78d0a921
is: Q9Y5B8
initial concentration: NaN
name: NME7
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29922
has only substance units: false
boundary condition: true
type: Species

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM malt e
constant: false
is: HMDB00163
initial amount: NaN
is: SBO:0000247
is: CHEBI:17306
initial concentration: 1.0
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
boundary condition: false
has only substance units: false
name: Maltose
is: C00208

metaM cys L c
is: HMDB00574
type: Species
name: L-cysteine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17561
has only substance units: false

metaM biocyt c
is: C05552
initial concentration: 1.0
initial amount: NaN
name: Biocytin
is: HMDB03134
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_fdd04b08_e403_483d_9416_91f11b701f5f
is: SBO:0000252
is: Q14916
name: SLC17A1
type: Species
is encoded by: hsa:6568
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_66a90d51_ac7a_4d73_a442_a6c8db556ca7
type: Species
name: PLA2G3
is encoded by: hsa:50487
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q9NZ20
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_6bc478f4_160a_4b8d_ad37_7473d6229ec9
is encoded by: hsa:197257
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
name: LDHD
is: Q86WU2
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_dd8e58ae_a7fb_440d_819d_193804dd0e07
is: SBO:0000252
boundary condition: true
name: _M68895_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:M68895
constant: false
has only substance units: false
initial amount: NaN

metaM sphmyln hs g
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58216
name: sphingomyelin betaine

metaM ppi e
constant: false
boundary condition: false
name: Diphosphate
is: SBO:0000247
is: CHEBI:33019
has only substance units: false
initial amount: NaN
is: HMDB00250
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_7edebc13_de2a_492e_a007_792b204e91c9
constant: false
initial concentration: NaN
is: SBO:0000297
has only substance units: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P48201
boundary condition: true
type: Species
is encoded by: hsa:518

http://identifiers.org/biomodels.db/MODEL1310110040#_c32b9d3b_dd66_459d_945f_053a930d15ac
is: Q14432
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PDE3A
constant: false
boundary condition: true
is encoded by: hsa:5139
type: Species
has only substance units: false

metaM ksii core4 pre8 g
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: HMDB00175
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
is: C00130
constant: false
is: SBO:0000247
type: Species

metaR TTDCRNt
is described by: ECO:0000000
reactant: MODEL1310110040#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction

metaM guln c
is: CHEBI:13115
is: SBO:0000247
name: L-gulonate
initial amount: NaN
is: HMDB03290
initial concentration: 1.0
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
type: Species
has only substance units: false

metaM cl c
type: Species
initial amount: NaN
is: CHEBI:3966
is: SBO:0000247
constant: false
is: HMDB00492
initial concentration: 1.0
name: Chloride
notes: FORMULA: Cl CHARGE: -1
has only substance units: false
is: C00115
boundary condition: false

metaR BUP2
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)

metaM 3pg m
boundary condition: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false
type: Species
constant: false
is: HMDB00807
is: CHEBI:58272
initial concentration: 1.0
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
initial amount: NaN

metaM crvnc c
name: cervonic acid, C22:6 n-3
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1
is: HMDB02183
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:36005
constant: false
initial amount: NaN
boundary condition: false

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaM glyc R m
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16659
name: D-glycerate
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00139

metaR FAS180COA
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C18:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110040#

metaR DOLPMT2 Ler
is: SBO:0000176
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
reversible: false
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction

metaR r0926
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction
reversible: false
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
fast: false
kinetic law: MODEL1310110040#

metaR r1252
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110040#
name: EC:6.2.1.3
is: SBO:0000176
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_c1b852f0_3ba1_417c_9cc1_2776415ab107
type: Species
initial concentration: NaN
boundary condition: true
name: SLC2A13
is: Q96QE2
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:114134

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reactant: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD

metaR FATP2t
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
name: fatty acid electroneutral transport
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_42e5191f_3d98_4f39_9104_a0d090aba9dc
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5805
name: PTS
type: Species
constant: false
boundary condition: true
is: Q03393
has only substance units: false

metaR BTNDe
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
type: Reaction
reactant: MODEL1310110040#
name: biotinidase (biotin), extracellular
is: SBO:0000176
product: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR C3STDH1r
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
reversible: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000134
reactant: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4463d30e_d5ba_4ac3_b8f3_0b67a337ce75
has only substance units: false
initial amount: NaN
type: Species
name: _LOC727762_1_m
constant: false
is encoded by: hsa:LOC727762
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM ppi c
is: CHEBI:0
is: C00013
is: HMDB00250
is: SBO:0000247
type: Species
name: Diphosphate
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_9409a65d_f425_43a9_bbc5_9a783cb3897f
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AL525798_1_c
type: Species
is encoded by: hsa:AL525798

metaR NACHEX14ly
reversible: false
reactant: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaR ACCOAtn
reversible: true
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: acetyl-CoA transport, nuclear
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_72710602_05ff_4d96_b09a_0c046c3735dc
is encoded by: hsa:57468
is: Q9H2X9
type: Species
name: SLC12A5
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_0cb92ac2_04a4_43cd_9880_d2be0cea3a7a
constant: false
is encoded by: hsa:5095
boundary condition: true
has only substance units: false
type: Species
is: C9JPQ8
initial concentration: NaN
is: SBO:0000252
name: PCCA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_1ad408fc_8548_4574_837f_40f41d82f7a2
has only substance units: false
is: Q5SYN6
name: SLC22A3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6581
is: SBO:0000252
type: Species
boundary condition: true
constant: false

metaM estradiol r
is: HMDB00151
is: CHEBI:16469
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
name: estradiol
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false

metaM psyl e
boundary condition: false
initial amount: NaN
name: psyllium
type: Species
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR EICOSTETCRNt
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
reversible: false
modifier: MODEL1310110040#
name: transport into the mitochondria (carnitine)
fast: false

metaR C101CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR r2124
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_e9019a42_7701_46bf_9dda_3c4d340fab51
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: SLC25A13
boundary condition: true
is: Q9UJS0
is encoded by: hsa:10165

http://identifiers.org/biomodels.db/MODEL1310110040#_e744ded9_56cc_4e3e_b1f6_5a7e8e7a97f7
initial amount: NaN
constant: false
name: _W87865_1_c
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:W87865
initial concentration: NaN

metaM 34dhmald m
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
constant: false
is: HMDB06242
type: Species
name: 3,4-Dihydroxymandelaldehyde
is: C05577
initial concentration: 1.0

metaR r0791
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110040#

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM 5pmev x
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
type: Species
is: HMDB01343
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58146
is: SBO:0000247
name: (R)-5-phosphonatomevalonate(3-)
boundary condition: false
initial concentration: 1.0

metaM mag hs c
initial amount: NaN
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false
is: HMDB12130
is: CHEBI:16987
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_f57577bf_9275_4c17_849a_68ad13fbd3ba
initial amount: NaN
type: Species
constant: false
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
is encoded by: hsa:5148
boundary condition: true
has part: O43924
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: P18545
is encoded by: hsa:5147

metaR LNELDCCPT2
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
name: carnitine transferase
modifier: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_e627318e_44be_4811_92bc_2f658354b8f4
boundary condition: true
constant: false
name: PANK1
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q8TE04
is encoded by: hsa:53354
initial concentration: NaN

metaR C4STMO1r
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
is described by: ECO:0000000
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.72
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
type: Reaction
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_c172da2f_907c_49ca_bc37_c23810ea4d02
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: _AI769281_1_e
is encoded by: hsa:AI769281
has only substance units: false
initial amount: NaN

metaR AATAi
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.7
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
type: Reaction
fast: false
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
is: SBO:0000176
name: 2-aminoadipate transaminase, irreversible

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR r2125
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_4ce48508_aa13_414a_829b_c17728748934
constant: false
boundary condition: true
is: P06576
type: Species
is encoded by: hsa:506
has only substance units: false
name: ATP5B
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM CE5788 e
is: HMDB02710
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial amount: NaN
type: Species
has only substance units: false
name: kinetensin 1-7
is: CHEBI:27485
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_5ee6b469_7813_482a_8052_9dbb9f60e5d8
name: DGKD
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8527
has only substance units: false
is: SBO:0000252

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM mag hs e
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:60479
initial concentration: 1.0
name: monoacylglycerol 2

metaR PDHm
fast: false
name: pyruvate dehydrogenase
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.12
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.2.4.1
reversible: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
type: Reaction

metaR 24 25DHVITD2t
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: 24,25-Dihydroxyvitamin D2 transport from cytoplasm
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#

metaR PI45PLC
modifier: MODEL1310110040#
reversible: false
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C

metaR RE3567C
fast: false
is: SBO:0000176
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
is described by: ECO:0000000
name: RE3567

metaM m7mpdol L r
is: SBO:0000247
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37636
initial concentration: 1.0
constant: false

metaR r2126
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_def301cf_4fee_4a75_a68a_921e41b34c4c
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1103
name: CHAT
is: Q6LEN6
is: SBO:0000252

metaM nrpphr e
constant: false
is: CHEBI:33569
boundary condition: false
initial concentration: 1.0
name: Norepinephrine
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00216
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaR r1421
name: Free diffusion
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_bb2020f8_1984_4232_8893_3b94975e41b3
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5335
boundary condition: true
is: P19174
name: PLCG1
initial concentration: NaN
initial amount: NaN

metaR NRVNCt
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110040#
fast: false

metaR GLUNm
name: glutaminase (mitochondrial)
modifier: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.1.2
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
is: SBO:0000176

metaR r2120
modifier: MODEL1310110040#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#

metaR DM Lcystin
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaM odecrn m
initial amount: NaN
initial concentration: 1.0
is: C00412
constant: false
boundary condition: false
is: CHEBI:57394
type: Species
name: octadecenoyl carnitine
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: HMDB01114
has only substance units: false

metaM hs deg15 l
name: heparan sulfate, degradation product 15
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110040#_efa53c4c_e903_439e_8186_f65a81470e41
has only substance units: false
type: Species
is encoded by: hsa:515
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000297

metaM gt3 hs g
name: GT3
has only substance units: false
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28424
boundary condition: false
type: Species
initial amount: NaN

metaR 5MTHFt2le
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110040#
is: SBO:0000185
name: 5-methyltetrahydrofolate transport via anion exchange
is described by: ECO:0000134
product: MODEL1310110040#
reversible: true
fast: false

metaR r2121
is: SBO:0000185
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110040#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR r0620
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
is: SBO:0000176
reversible: true
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000
fast: false

metaR ILETAm
name: isoleucine transaminase, mitochondrial
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction

metaM lnlccoa c
name: linoleic coenzyme A
boundary condition: false
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
constant: false
initial concentration: 1.0
is: HMDB01064
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_b7fdd971_2c9d_473e_92ad_e959e27c2bf7
name: SRD5A2
is encoded by: hsa:6716
boundary condition: true
type: Species
is: P31213
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR SERDGLYexR
type: Reaction
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
name: D-Serine/Glycine reversible exchange
fast: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000304
kinetic law: MODEL1310110040#

metaR VLCSr
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#

metaR TETDEC2CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_eb23c736_54d1_4a22_94d7_b327ec9814bb
initial concentration: NaN
is: Q9Y619
is encoded by: hsa:10166
name: SLC25A15
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR A4GNT2g
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_9be20b3d_0475_49a5_b3b6_3032308e9f66
is: SBO:0000252
is encoded by: hsa:84532
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q9NUB1
boundary condition: true
name: ACSS1
constant: false

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110040#
reversible: true

metaM 4abutn e
boundary condition: false
is: HMDB01080
initial concentration: 1.0
type: Species
initial amount: NaN
name: 4-ammoniobutanal
is: SBO:0000247
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
has only substance units: false

metaR CYTK10n
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
kinetic law: MODEL1310110040#

metaR r2122
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
fast: false
type: Reaction

metaR GLCGLUT2
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
product: MODEL1310110040#
name: Transport of glucose into the portal blood
notes: GENE_ASSOCIATION: (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 71-74 NOTES:GLUT-2 can also move to the apical surface and aid in glucose import into the cell under fully fed state (PMID: 17786952)
is described by: ECO:0000134
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
fast: false

metaM g3m8masn r
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial amount: NaN
is: C05873

metaR LNELDCCPT1
product: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110040#

metaM ile L m
is: CHEBI:17191
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: L-isoleucine
has only substance units: false
boundary condition: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM HC02203 e
is: CHEBI:27820
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: prostaglandin-a2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_41c89038_7b7e_4304_8b7b_17a5e07da7d6
boundary condition: true
is: P22234
type: Species
initial amount: NaN
is: SBO:0000252
name: PAICS
is encoded by: hsa:10606
initial concentration: NaN
constant: false
has only substance units: false

metaR DOLPH Ler
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
is: SBO:0000176
product: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
type: Reaction
name: Dolichol-phosphate phosphohydrolase, human (liver)
fast: false

metaR PPAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8135845 NOTES:TDV Short-chain fatty acid can diffuse through mitochondrial membrane
kinetic law: MODEL1310110040#
name: Propionate transport, diffusion
reversible: false
reactant: MODEL1310110040#
type: Reaction
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185

metaR ST8SIA53g
fast: false
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000269
type: Reaction

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM msa m
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:33190
is: SBO:0000247
name: 3-oxopropanoate
is: HMDB11111
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_56338e89_edbf_444f_85c7_78aa82718f42
initial amount: NaN
constant: false
is encoded by: hsa:AI469183
is: SBO:0000252
name: _AI469183_1_x
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR r0494
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
type: Reaction
reversible: true

metaR MANtly
name: mannose efflux from lysosome
type: Reaction
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110040#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_395318a9_d6f9_45a2_b8a6_155619731d89
is encoded by: hsa:3032
name: HADHB
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: P55084

metaR r2123
fast: false
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
is: SBO:0000185
product: MODEL1310110040#
is described by: ECO:0000000

metaM hco3 m
initial amount: NaN
name: Bicarbonate
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
is: HMDB00595
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_312301bf_4d28_4871_a91b_814b9b169ae2
is encoded by: hsa:2538
initial concentration: NaN
initial amount: NaN
name: G6PC
type: Species
boundary condition: true
is: P35575
is: SBO:0000252
constant: false
has only substance units: false

metaM pydxn c
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
initial concentration: 1.0
is: CHEBI:16709
is: HMDB00239
name: Pyridoxine
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00314
constant: false

metaR ASNNm
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000254
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.1.1
reactant: MODEL1310110040#
fast: false
name: L-asparaginase (mitochondrial)
modifier: MODEL1310110040#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_a400f609_d2fb_49bc_a73f_d30267384e8a
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: PDE6A
is: SBO:0000252
type: Species
is: P16499
is encoded by: hsa:5145

http://identifiers.org/biomodels.db/MODEL1310110040#_14efa702_b363_49ef_8990_b87224a0289f
name: NME1
boundary condition: true
is encoded by: hsa:4830
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c0f60296_c3e4_44b0_b293_ab08848fd06d
name: AKR1B1
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: P15121
is encoded by: hsa:231
is: SBO:0000252

metaR r1428
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#

metaM m2mpdol L c
initial amount: NaN
is: CHEBI:28049
initial concentration: 1.0
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
boundary condition: false
type: Species
constant: false

metaR CSNATm
fast: false
name: carnitine O-aceyltransferase, mitochondrial
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
is described by: ECO:0000269
product: MODEL1310110040#
modifier: MODEL1310110040#

metaR LGTHL
kinetic law: MODEL1310110040#
name: lactoylglutathione lyase
type: Reaction
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.4.1.5

metaM ha l
type: Species
has only substance units: false
name: hyaluronan
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
is: CHEBI:16336
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM c16dc e
name: Hexadecanedioic acid mono-L-carnitine ester
initial amount: NaN
notes: FORMULA: C23H42NO6 CHARGE: -1
has only substance units: false
is: HMDB00712
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_a9142cb6_a1e8_4981_a0e5_c61ea3ae8293
initial concentration: NaN
name: CDA
is: P32320
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:978
constant: false
type: Species
initial amount: NaN

metaR ACACT10m
is: SBO:0000176
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is described by: ECO:0000134
fast: false
modifier: MODEL1310110040#

metaR S6TASE3ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
reactant: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaM dtmp m
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP
is: CHEBI:26999
type: Species
is: SBO:0000247
is: HMDB01227
boundary condition: false
is: C00364

http://identifiers.org/biomodels.db/MODEL1310110040#_bd56915b_0101_4977_a674_541aaca25d06
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5146
type: Species
is: P51160
name: PDE6C
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_25e73cd2_1ffa_440f_a13a_d7568559f852
initial concentration: NaN
is: P54819
constant: false
initial amount: NaN
name: AK2
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:204

metaR CYANt
reversible: true
product: MODEL1310110040#
type: Reaction
name: Cyanide transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_63ed00f1_9f44_4133_ac6b_6320b0f6d404
initial amount: NaN
boundary condition: true
is: Q8TCG5
has only substance units: false
is: SBO:0000252
name: CPT1C
is encoded by: hsa:126129
type: Species
initial concentration: NaN
constant: false

metaR RE2660N
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
product: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110040#
fast: false
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: RE2660

http://identifiers.org/biomodels.db/MODEL1310110040#_4973390c_fbcf_4e52_8646_29d1d5edc78b
type: Species
is: Q16842
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: ST3GAL2
initial concentration: NaN
is encoded by: hsa:6483
initial amount: NaN

metaM odecrn c
has only substance units: false
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: C00412
is: SBO:0000247
boundary condition: false
is: HMDB01114
initial amount: NaN
initial concentration: 1.0
name: octadecenoyl carnitine
constant: false
is: CHEBI:57394

metaR r0774
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110040#
reversible: true
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_66cb400b_985c_4e43_b9db_617bc78ca3de
name: NDUFA6
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4700
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: P56556

http://identifiers.org/biomodels.db/MODEL1310110040#_6dc70451_d097_42d9_937e_8b4fc2fade2a
initial concentration: NaN
is encoded by: hsa:5320
boundary condition: true
has only substance units: false
type: Species
name: PLA2G2A
initial amount: NaN
is: SBO:0000252
is: P14555
constant: false

metaR 2AMADPTm
is described by: ECO:0000269
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110040#
type: Reaction
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR AKGDm
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.61
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000134
name: 2-oxoglutarate dehydrogenase
type: Reaction
reversible: false
kinetic law: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM andrstrn r
constant: false
is: SBO:0000247
is: HMDB00031
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
name: androsterone
is: CHEBI:16032
type: Species

metaM c16dc c
has only substance units: false
notes: FORMULA: C23H42NO6 CHARGE: -1
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00712
initial concentration: 1.0
constant: false
name: Hexadecanedioic acid mono-L-carnitine ester
is: SBO:0000247

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110040#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#

metaM 6thf e
constant: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: SBO:0000247
name: hexaglutamyl folate (THF)
type: Species
is: http://identifiers.org/pubchem.compound/169691
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r1429
reversible: true
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
type: Reaction
is: SBO:0000185

metaR IVCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR NACHEX27ly
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_0316494c_9bb4_4116_9299_308147e60fa0
is encoded by: hsa:U37519
type: Species
name: _U37519_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaR CSNATr
fast: false
reversible: true
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
name: carnitine O-acetyltransferase
is: SBO:0000176
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_151e427a_9025_48a1_b10b_5a430cf872fa
initial concentration: NaN
type: Species
is encoded by: hsa:10476
name: ATP5H
is: O75947
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM pro L m
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: L-proline
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17203
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

http://identifiers.org/biomodels.db/MODEL1310110040#_489df781_1b0e_4137_b510_f6d81472ddf3
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2572
initial amount: NaN
is: SBO:0000252
name: GAD2
is: Q5VZ30
has only substance units: false

metaR DOLASNT Ler
fast: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.119
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaM arachcrn m
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN

metaR 4NPHte
is: SBO:0000185
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
type: Reaction
name: xenobiotic transport
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_861c9c93_0cc2_44bb_a818_cac641dcd658
is encoded by: hsa:112724
has only substance units: false
is: B3KVA3
initial amount: NaN
name: RDH13
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM nmn n
initial amount: NaN
type: Species
name: NMN(-)
boundary condition: false
is: CHEBI:14649
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00229
is: SBO:0000247
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455

http://identifiers.org/biomodels.db/MODEL1310110040#_05fd0345_97ae_417a_a430_08cd70b07f78
constant: false
name: GUCY1B3
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q02153
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2983

http://identifiers.org/biomodels.db/MODEL1310110040#_c7007b93_0927_47e7_8586_f69e68771594
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:37
initial amount: NaN
has only substance units: false
type: Species
is: P49748
name: ACADVL
initial concentration: NaN

metaM cs b l
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: CHEBI:36005
is: HMDB02183
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_6bb83264_8a7a_4e67_a31d_fa348b0ce5af
type: Species
is: Q06830
name: PRDX1
constant: false
is encoded by: hsa:5052
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR CSEPASEly
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
type: Reaction
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176

metaR RE3556C
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3556
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_cd20ce98_96be_4182_ae34_070ed1306ae1
is encoded by: hsa:23563
initial amount: NaN
is: Q9GZS9
initial concentration: NaN
has only substance units: false
boundary condition: true
name: CHST5
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_4e890001_969c_4cd6_a944_fd2da33d13c5
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:286297
type: Species
name: _286297_1_c
constant: false
has only substance units: false

metaR RNDR1
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
is described by: ECO:0000254
product: MODEL1310110040#

metaR FUMSO4tm
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
name: Fumarate:sulfate antiport, mitochondrial
fast: false
reactant: MODEL1310110040#

metaR FBP26
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
name: Fructose-2,6-bisphosphate 2-phosphatase
is version of: http://identifiers.org/ec-code/2.7.1.105
reactant: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.11
type: Reaction

metaR RNMK
reversible: false
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.22
modifier: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
name: ribosylnicotinamide kinase
fast: false

metaR LNSTLSr
product: MODEL1310110040#
name: lanosterol synthase
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is version of: http://identifiers.org/ec-code/5.4.99.7
reversible: false
modifier: MODEL1310110040#
type: Reaction
fast: false
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_969ef185_65f5_4a5d_a164_9f368d01993b
name: PDE8A
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:5151
boundary condition: true
is: SBO:0000252

metaM cs a deg1 l
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
type: Species
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:57455
is: HMDB01354
initial concentration: 1.0
is: SBO:0000247

metaR CSNATp
fast: false
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110040#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
type: Reaction
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110040#

metaR FRDPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
reversible: true

metaM ttdca c
boundary condition: false
name: myristate
is: SBO:0000247
is: HMDB00806
has only substance units: false
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
initial concentration: 1.0
is: CHEBI:30807
initial amount: NaN
type: Species

metaR ECOAH1m
kinetic law: MODEL1310110040#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110040#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110040#_3851d060_e939_42f2_aa6a_3e748b32bed7
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8659
name: ALDH4A1
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM tdchola x
boundary condition: false
is: CHEBI:9407
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: taurochenodeoxycholate
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951

metaR RE1518M
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1518
modifier: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaR RNDR4
fast: false
name: ribonucleoside-diphosphate reductase (UDP)
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
type: Reaction
reversible: false

metaR RDH2a
name: retinol dehydrogenase (9-cis,NADPH)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.300
type: Reaction
reversible: true
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.105
fast: false
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_c7fd90cf_3f9c_494d_866f_5f9659b58b5a
is encoded by: hsa:6799
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: P50226
name: SULT1A2
is: SBO:0000252

metaM malcoa c
is: CHEBI:57384
name: Malonyl-CoA
initial amount: NaN
is: HMDB01175
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: C00083
boundary condition: false
has only substance units: false

metaR METt4
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
product: MODEL1310110040#
fast: false
type: Reaction
name: L-methionine transport in via sodium symport
modifier: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000269

metaR FUMtm
name: fumarate transport, mitochondrial
product: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaR r0796
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
is: SBO:0000176

metaM pail345p hs c
type: Species
boundary condition: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
is: CHEBI:57836
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_50d21247_d6f8_4f8e_b1d8_c5e1a8815516
boundary condition: true
constant: false
initial amount: NaN
name: AQP8
is: SBO:0000252
is encoded by: hsa:343
has only substance units: false
initial concentration: NaN
type: Species
is: O94778

http://identifiers.org/biomodels.db/MODEL1310110040#_6adefae4_7fbb_41c9_94f7_b98a1e539a30
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: _H17063_1_m
boundary condition: true
is: SBO:0000252
is encoded by: hsa:H17063
initial amount: NaN

metaM gal1p c
is: HMDB00645
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
is: SBO:0000247
boundary condition: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: CHEBI:58336
has only substance units: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_943a8372_a85e_4596_a446_edd6bca6010c
initial amount: NaN
has only substance units: false
is: Q9P0Z9
type: Species
is encoded by: hsa:51268
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: PIPOX

http://identifiers.org/biomodels.db/MODEL1310110040#_ad771fe6_8919_4b05_b334_27e2d52c8b5f
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:518
constant: false
initial amount: NaN
name: ATP5G3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_051d579e_e785_4867_8d2b_402cd6efe8ca
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN
constant: false
initial concentration: NaN
has part: B4E3E9
name: DLD:DLST:OGDH:PDHX
has only substance units: false
type: Species
is: SBO:0000297

metaM dgmp m
is: SBO:0000247
constant: false
is: HMDB01044
boundary condition: false
has only substance units: false
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
type: Species
initial concentration: 1.0
initial amount: NaN
name: dGMP

metaR r0797
is: SBO:0000176
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: true
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
fast: false
product: MODEL1310110040#

metaR RE3624M
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110040#
is: SBO:0000176
name: RE3624
type: Reaction

metaM thp2c x
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: HMDB12130
initial amount: NaN
constant: false
initial concentration: 1.0
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
is: SBO:0000247

metaM hco3 e
initial amount: NaN
is: CHEBI:17544
name: Bicarbonate
is: C00288
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00595
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

http://identifiers.org/biomodels.db/MODEL1310110040#_c40cd6e5_f30a_4751_8b4a_26c38f87720c
is encoded by: hsa:4717
initial concentration: NaN
is: O43677
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: NDUFC1
boundary condition: true

metaR C180CRNt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: C180 transport into the mitochondria
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false

metaM bildglcur c
is: SBO:0000247
is: CHEBI:58471
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
constant: false
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
is: HMDB03325
initial amount: NaN
has only substance units: false

metaR DHFR
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reversible: true
modifier: MODEL1310110040#
is described by: ECO:0000254
name: dihydrofolate reductase
kinetic law: MODEL1310110040#

metaR GD1Cte
type: Reaction
name: gd1c hs transport
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185

metaR UDPGLCter
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_9bfaf6bf_1085_4151_a8e8_7d2016303862
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:762
constant: false
is: Q6FHI7
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: CA4

metaR S6T3g
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176

metaM hco3 c
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
name: Bicarbonate
initial concentration: 1.0
is: HMDB00595
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: C00288
has only substance units: false

metaM vacccrn c
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06351
name: Vaccenyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
is: SBO:0000247
constant: false
boundary condition: false

metaM ksii core4 pre7 g
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 7
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58053
is: C00130
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_05ff4290_858a_45ca_8fcf_d6ed55c8ebe3
has only substance units: false
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1716
name: DGUOK

metaM ga2 hs g
is: SBO:0000247
constant: false
name: GA2
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
is: CHEBI:465284
type: Species
boundary condition: false

metaR S2TASE1ly
is: SBO:0000176
kinetic law: MODEL1310110040#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
type: Reaction

metaR r1721
product: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
reversible: false
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_99e9e33b_dc4e_4165_b797_b817f4bf7c5a
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000297
has part: P08559
is encoded by: hsa:5160
initial amount: NaN
has only substance units: false
name: DLAT:DLD:PDHA1:PDHB:PDHX

metaR RE1807M
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
name: RE1807
is: SBO:0000176
reversible: true
type: Reaction

metaM ksi pre18 g
is: HMDB00175
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
type: Species
boundary condition: false
is: CHEBI:58053
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 18
is: C00130

metaM cmpacna n
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57812
boundary condition: false
is: HMDB01176
has only substance units: false
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_26eea7ef_7f06_4a44_900e_ff4d281600f1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2098
name: ESD
is: P10768
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_a55ec4e1_879b_4906_90cb_d79419d7ecb8
type: Species
constant: false
is: O43181
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4724
initial amount: NaN
name: NDUFS4
boundary condition: true

metaM fpram c
is: C04640
is: SBO:0000247
is: HMDB06211
constant: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: Species
is: CHEBI:58478
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
initial concentration: 1.0

metaR CITtbm
product: MODEL1310110040#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110040#
type: Reaction
fast: false
name: citrate transport, mitochondrial
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF

metaR S4TASE1ly
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
is described by: ECO:0000000
modifier: MODEL1310110040#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110040#
fast: false
reversible: true

metaR SADT
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25

http://identifiers.org/biomodels.db/MODEL1310110040#_bc5dbf84_087b_4858_8c6c_a7aa347e928a
is encoded by: hsa:54344
initial concentration: NaN
type: Species
name: DPM3
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: Q86TM7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_374bf063_8575_4717_8a97_b7c81c816c24
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: NUDT12
initial amount: NaN
is encoded by: hsa:83594
initial concentration: NaN
is: Q9BQG2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_8a4c26f9_00a2_44bf_8250_27df5fda66a7
is encoded by: hsa:18
name: ABAT
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_402a77a3_e3ef_4ee7_8190_826b91e496fd
is: Q9BV10
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ALG12
is: SBO:0000252
is encoded by: hsa:79087
constant: false
has only substance units: false
type: Species

metaR r0345
modifier: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
type: Reaction
product: MODEL1310110040#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_7c9de8ab_9342_4101_b64e_cf5a588f7ef5
initial amount: NaN
name: DGKI
boundary condition: true
constant: false
is encoded by: hsa:9162
initial concentration: NaN
is: O75912
type: Species
is: SBO:0000252
has only substance units: false

metaR RTOTAL2t
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport

http://identifiers.org/biomodels.db/MODEL1310110040#_8b1ddce0_f0ee_4331_9b7d_38ad8cb1feb8
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI694761
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AI694761_1_c

metaM dhap x
is: C00111
boundary condition: false
initial concentration: 1.0
is: CHEBI:57642
type: Species
name: Dihydroxyacetone phosphate
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
has only substance units: false

metaM ttdca e
initial amount: NaN
type: Species
name: tetradecanoate (n-C14:0)
is: HMDB00806
has only substance units: false
is: CHEBI:30807
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
boundary condition: false
is: C06424
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR DLNLCGCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
product: MODEL1310110040#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
kinetic law: MODEL1310110040#
is: SBO:0000176

metaM 3ohdcoa m
initial amount: NaN
is: HMDB06402
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
has only substance units: false
is: CHEBI:57349
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
constant: false
boundary condition: false
type: Species
is: SBO:0000247

metaR FUCASE2ly
is version of: http://identifiers.org/ec-code/3.2.1.51
fast: false
modifier: MODEL1310110040#
name: alpha-fucosidase, lysosomal
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
reversible: false
kinetic law: MODEL1310110040#

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR BETALDHxm
is described by: ECO:0000000
name: betaine-aldehyde dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_6da9ef82_3568_4c1b_b84d_74ba1a6a0aab
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR C80CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_df415a80_e0c1_4060_9532_0d817ed8e2c5
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5152
constant: false
initial amount: NaN
name: PDE9A

metaR FATP1t
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
modifier: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
name: fatty acid electroneutral transport
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
fast: false

metaR LCYSTAT
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
kinetic law: MODEL1310110040#
is described by: ECO:0000304
fast: false
reversible: true
name: L-Cysteate:2-oxoglutarate aminotransferase
type: Reaction
is: SBO:0000176

metaR ATP2ter
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
name: AMP/ATP transporter, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110040#

metaM dha e
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01882
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone
type: Species
is: CHEBI:16016

metaM CE5121 m
name: trans-3-decenoyl-CoA
is: CHEBI:57449
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial concentration: 1.0
constant: false

metaR MM6bg
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110040#

metaR GD1Ctg
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: gd1c hs intracellular transport
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_c998cfd9_c1e7_4722_8dc8_facf20b52e41
name: SLC27A2
boundary condition: true
is encoded by: hsa:11001
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: O14975

metaM arachcrn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: arachidyl carnitine
boundary condition: false
is: HMDB06460
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_83179a08_6c66_4643_99d3_0e8ae4a2aa95
type: Species
constant: false
is encoded by: hsa:56052
is: Q9BT22
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ALG1
has only substance units: false

metaM ala B c
is: HMDB00056
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
is: CHEBI:16958
initial concentration: 1.0
name: beta-alanine
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaM mn l
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06535
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
type: Species

metaR GMPtn
kinetic law: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
fast: false
type: Reaction
name: GMP nuclear transport
is described by: ECO:0000000
product: MODEL1310110040#

metaR AG13T18g
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110040#

metaR CSPG Btly
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
name: chondroitin sulfate B transport, extracellular to lysosome
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185

metaR NDPK7n
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is: SBO:0000176
modifier: MODEL1310110040#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_9bd69fb8_54cc_431a_90fe_8240a5063850
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23057
name: NMNAT2
has only substance units: false
constant: false
type: Species

metaR PHEMEt
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
name: heme transport
is: SBO:0000185
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_f8e13cfe_1ce1_480f_8067_797f34686e54
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: HAS1
type: Species
is encoded by: hsa:3036
is: SBO:0000252
is: Q8IYH3

http://identifiers.org/biomodels.db/MODEL1310110040#_8b9c3ed9_5eec_48ab_a9b4_54f39125e0be
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:2530
type: Species
name: FUT8
is: G3V5N0
is: SBO:0000252

metaM 3octdece1crn c
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxy-octadecenoyl carnitine
is: HMDB13336
constant: false
notes: FORMULA: C25H47NO5 CHARGE: 0
has only substance units: false

metaR AG13T7g
product: MODEL1310110040#
reactant: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
fast: false

metaM pro L e
is: CHEBI:17203
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
type: Species
name: L-proline
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9fa43f54_a500_4c90_a1d8_892ab14c7fb5
type: Species
boundary condition: true
is encoded by: hsa:2544
name: _2544_1_c
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_6886a41e_e5d7_43d6_85e2_fa77a1bb4f41
initial concentration: NaN
is: P04745
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: AMY1B
is encoded by: hsa:277
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_4301975a_16c7_4f1f_a320_17bcae4d5a3e
name: NDUFV3
is: P56181
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4731
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_24e4144e_7f55_4ebb_afbc_620ab6ed7aaa
name: HK1
type: Species
is encoded by: hsa:3098
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: P78542

metaR G14T18g
reactant: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false

metaM ksii core4 pre5 g
is: C00130
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C69H112N6O48X CHARGE: -1
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
type: Species
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110040#_6bddd3ac_e4c3_4909_bb92_7a10175791ef
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:3098
has only substance units: false
constant: false
is: SBO:0000252
name: HK1
is: A8K7J7

http://identifiers.org/biomodels.db/MODEL1310110040#_470ec949_b1e5_4285_8da3_bdd8f9477571
has only substance units: false
is: SBO:0000252
is: Q96NT5
constant: false
name: SLC46A1
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:113235

metaM HC00591 m
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: 2-oxoglutaramate
is: CHEBI:16769
boundary condition: false
constant: false
is: SBO:0000247

metaR DLNLCGCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
type: Reaction
name: carnitine transferase
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_3e2ec848_c380_41aa_b078_524d924c681b
is encoded by: hsa:4712
name: NDUFB6
is: O95139
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252

metaR MTHFR3
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
modifier: MODEL1310110040#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.20
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.

metaM ade c
is: CHEBI:16708
type: Species
is: C00147
constant: false
is: HMDB00034
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: Adenine
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_7c902792_105f_40d6_98c5_5bd2ea9040ee
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:377841
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: ENTPD8
is: Q5MY95

http://identifiers.org/biomodels.db/MODEL1310110040#_bfa4c0ed_3d99_40de_bd9b_2beb7a676bbc
is: A8K0I1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:160851
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: DGKH

metaR MI134P4P
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
name: inositol-1,3,4-trisphosphate 4-phosphatase
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false

metaM g6p r
is: C00092
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial concentration: 1.0
name: D-Glucose 6-phosphate
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01401
type: Species
is: CHEBI:61548
constant: false
has only substance units: false

metaM 7dhchsterol r
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:17759
initial concentration: 1.0
boundary condition: false
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol

metaR DCK1n
fast: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
name: Deoxycytidine kinase, nuclear (ATP)

metaR LGNCt
type: Reaction
kinetic law: MODEL1310110040#
name: fatty acid transport via diffusion
reactant: MODEL1310110040#
fast: false
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_7e1542c8_fa76_426c_a082_fbde81218deb
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:BE966236
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: _BE966236_1_c

metaM gpail hs c
initial concentration: 1.0
is: CHEBI:17049
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
type: Species

metaR PMEVKx
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110040#
name: phosphomevalonate kinase
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#

metaM sphings l
type: Species
initial amount: NaN
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: CHEBI:57756
has only substance units: false
is: HMDB00252
constant: false
is: SBO:0000247
name: sphingosine(1+)
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_45aa0767_5238_42cc_80ed_871665d212fb
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1215
constant: false
boundary condition: true
is: SBO:0000252
name: CMA1
is: Q4FEB3
initial amount: NaN
type: Species

metaM CE2838 e
type: Species
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
has only substance units: false
constant: false
name: maltononaose
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
initial amount: NaN
is: C01936

metaM ha e
type: Species
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: hyaluronan
is: CHEBI:16336

metaM gam6p c
is: SBO:0000247
constant: false
name: D-Glucosamine 6-phosphate
initial amount: NaN
is: CHEBI:12962
initial concentration: 1.0
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
type: Species
is: HMDB01254
boundary condition: false
has only substance units: false

metaM 3octdece1crn e
constant: false
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0
has only substance units: false
is: HMDB13336
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 3-hydroxy-octadecenoyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_64bdeaa7_3551_40cf_9203_f3a8867ee7ca
is: O95299
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: NDUFA10
is: SBO:0000252
is encoded by: hsa:4705
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_02e2d63f_fd1a_4e1c_9baf_6ebf15d5d665
initial amount: NaN
type: Species
name: MPST
is: P25325
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4357
is: SBO:0000252

metaR DSREDUCr
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
name: Desmosterol reductase
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
type: Reaction

metaR RE3050R
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
name: RE3050
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_c9d0e5e1_4135_4bc5_a170_d5988c9c63e0
is: SBO:0000252
name: GGT2
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:728441
has only substance units: false
constant: false
boundary condition: true

metaM ade e
initial concentration: 1.0
is: CHEBI:16708
has only substance units: false
type: Species
constant: false
is: HMDB00034
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: adenine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_58a457ca_0077_4d3d_9d8f_ff43038a1c7d
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10380
initial amount: NaN
is: O95861
constant: false
type: Species
name: BPNT1

http://identifiers.org/biomodels.db/MODEL1310110040#_2ddebab1_179c_4666_88fb_101658faffe7
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
is: Q5T4W8
is encoded by: hsa:6487
constant: false
boundary condition: true
is: SBO:0000252

metaM omhpal c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06294
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
type: Species
initial amount: NaN
name: w-hydroxypalmiticacid

metaR DMNONCRNt
reversible: true
is described by: ECO:0000000
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaR EX ddecrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaM Rtotal2 c
is: C00055
name: R total 2 position
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:60377
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
type: Species
is: HMDB00095
is: SBO:0000247

metaR RE2799C
is: SBO:0000176
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: RE2799
fast: false
reversible: true
type: Reaction
product: MODEL1310110040#

metaR r0340
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#

metaM sph1p e
initial concentration: 1.0
constant: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
type: Species
is: HMDB01383
boundary condition: false
initial amount: NaN
is: CHEBI:57939
has only substance units: false

metaR 4MOPte
type: Reaction
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of 4-methyl-2-oxopentanoate

metaR HS3ly
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
modifier: MODEL1310110040#
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110040#

metaR r0033
modifier: MODEL1310110040#
fast: false
is: SBO:0000176
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction

metaM cmpacna g
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57812
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM btn c
constant: false
type: Species
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
has only substance units: false
name: Biotin
is: SBO:0000247
is: C00120
initial concentration: 1.0
is: CHEBI:3420
initial amount: NaN

metaM ksi pre31 g
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: C00130
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 31
constant: false

metaM atp c
is: CHEBI:30616
initial amount: NaN
initial concentration: 1.0
is: C00002
is: HMDB00538
is: SBO:0000247
name: ATP(4-)
has only substance units: false
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_ebafb7f0_4a53_49e8_8265_8840f1934af4
is encoded by: hsa:56606
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q9NRM0
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: SLC2A9

metaR NDPK3
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:CDP)
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR NDPK3n
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110040#
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear

metaM ksi pre35 g
name: keratan sulfate I biosynthesis, precursor 35
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
is: CHEBI:28067

metaM Rtotal2 e
is: C00255
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:3554
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: HMDB00244
type: Species
name: R total 2 position
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_2e3c39af_b035_4873_9114_67d84d113616
initial concentration: NaN
is encoded by: hsa:5331
type: Species
has only substance units: false
name: PLCB3
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: G5E960

metaM ksii core4 g
is: HMDB00189
is: CHEBI:57614
constant: false
type: Species
name: keratan sulfate II (core 4-linked)
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_ce043eab_7d44_4dbc_9f66_c38ca2503254
has only substance units: false
name: CA14
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:23632
is: A8K3J4
boundary condition: true

metaR ADK3
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
reactant: MODEL1310110040#
is described by: ECO:0000269
fast: false
reversible: true
name: adentylate kinase (GTP)
product: MODEL1310110040#

metaR ACACT5p
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
reversible: false
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction

metaM ksi deg15 l
type: Species
name: keratan sulfate I, degradation product 15
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00143

metaM HC02203 c
boundary condition: false
type: Species
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
initial amount: NaN
constant: false
name: prostaglandin-a2
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_8bbd30b7_7416_41b0_a628_92ed9aad6679
has only substance units: false
type: Species
is: Q9BV79
name: MECR
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:51102
is: SBO:0000252
constant: false

metaR NDPK2
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_f4f8fdf1_8115_4d53_87e5_8117926ac529
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8879
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SGPL1
is: O95470
has only substance units: false

metaM lnlncgcoa r
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
type: Species
boundary condition: false

metaR r0611
is version of: http://identifiers.org/ec-code/1.2.3.1
fast: false
reactant: MODEL1310110040#
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11

metaM sph1p c
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
boundary condition: false
is: HMDB01383
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaR GMPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
is: SBO:0000185
fast: false
reversible: true
name: GMP transport (Golgi)
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269

metaR RE1523M
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000000
modifier: MODEL1310110040#
reversible: true
name: RE1523
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaR MI14Ptn
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
reversible: true
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR NDPK1
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
reversible: true
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_db468560_285f_4769_9035_ac1b1c3ffae6
has part: Q7GXY8
is encoded by: hsa:84701
is encoded by: hsa:125965
is encoded by: hsa:4513
is encoded by: hsa:1327
is: SBO:0000297
is encoded by: hsa:1339
has part: P12074
has part: P13073
has part: Q8TF08
is encoded by: hsa:1345
has part: P00414
is encoded by: hsa:1337
is encoded by: hsa:1340
constant: false
has part: Q6YFQ2
is encoded by: hsa:1329
type: Species
has part: P20674
is encoded by: hsa:1349
has part: Q7Z4L0
has part: Q02221
is encoded by: hsa:4514
has part: Q96KJ9
has only substance units: false
has part: Q53YB7
initial amount: NaN
is encoded by: hsa:9167
has part: Q6FGA0
is encoded by: hsa:341947
is encoded by: hsa:4512
is encoded by: hsa:1346
has part: P24311
has part: H0UI06
is encoded by: hsa:170712
initial concentration: NaN
is encoded by: hsa:1347
has part: P15954
has part: Q7GXZ8
is encoded by: hsa:1350
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P09669
has part: P14854
is encoded by: hsa:9377
has part: Q53XN1
is encoded by: hsa:1351
boundary condition: true
has part: P24310

http://identifiers.org/biomodels.db/MODEL1310110040#_94bd9506_deee_4c78_b44c_ac262dc98e0a
constant: false
is encoded by: hsa:7167
is: SBO:0000252
has only substance units: false
is: Q53HE2
name: TPI1
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaM g3pc c
name: sn-Glycero-3-phosphocholine
initial amount: NaN
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: HMDB00086
constant: false
is: SBO:0000247
is: CHEBI:16870
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species

metaM retn r
is: CHEBI:35291
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
name: all-trans-retinoate
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852

metaR ACOAD8m
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
is version of: http://identifiers.org/ec-code/1.3.99.10
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110040#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
fast: false

metaR SCPx
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
reversible: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.176
product: MODEL1310110040#
type: Reaction
fast: false
name: peroxisomal thiolase 2
kinetic law: MODEL1310110040#

metaM pro L c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
type: Species
name: L-proline
is: HMDB00162
constant: false
initial concentration: 1.0
is: CHEBI:17203
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r0610
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
type: Reaction
is: SBO:0000176
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_2365eccc_e8a9_4c6e_a295_0b4bcda2cfd4
constant: false
is encoded by: hsa:50484
has only substance units: false
name: RRM2B
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q7LG56
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_64efff43_b7df_44ff_80b5_38ced2ed0633
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:123041
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC24A4

metaR DOLGLCP Lter
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR ADK1
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
fast: false
name: adenylate kinase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_1c7b798c_51ee_435c_8290_d14a7fa6f1b2
constant: false
boundary condition: true
is: SBO:0000252
name: SLC25A1
is: D9HTE9
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6576
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0be4afe3_f103_44c3_bea6_18fa5d126550
initial amount: NaN
type: Species
is encoded by: hsa:115111
boundary condition: true
initial concentration: NaN
is: Q8TE54
name: SLC26A7
has only substance units: false
is: SBO:0000252
constant: false

metaM CE2418 m
initial concentration: 1.0
is: HMDB11123
constant: false
has only substance units: false
type: Species
is: CHEBI:28387
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418

metaR ABTD
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
product: MODEL1310110040#
fast: false
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: L-arabinitol 4-dehydrogenase
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_51272818_ff39_4a3c_9bbb_fd7a8cb7dc4a
initial amount: NaN
type: Species
name: SLC26A8
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:116369
boundary condition: true

metaM mgacpail hs r
is: HMDB00220
type: Species
has only substance units: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: CHEBI:7896
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00249
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false

metaM 3thexddcoa c
initial concentration: 1.0
name: 3-hydroxy trans7,10-hexadecadienoylcoa
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
is: HMDB02014
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_aee5250b_3741_483c_b63b_83da0c23fdaf
is: B4DUY1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10948
is: SBO:0000252
name: STARD3
constant: false
has only substance units: false
type: Species

metaR FUMm
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110040#
is described by: ECO:0000134
name: fumarase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
type: Reaction
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_600d9136_f930_4760_b31c_add806dd5bfa
has only substance units: false
is encoded by: hsa:5211
type: Species
name: PFKL
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: Q7L2M7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_0a08b3d7_0c2b_47cd_a791_db53aa7bb577
type: Species
is: Q96I99
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8801
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: SUCLG2

metaR RE3243R
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110040#
name: RE3243
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
is described by: ECO:0000000

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110040#
type: Reaction

metaR r1872
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_9d6904e2_4ad5_4dd2_9660_685f7db950c6
is: SBO:0000252
is: Q9NPB1
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:56953
boundary condition: true
type: Species
name: NT5M

metaR r2129
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110040#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110040#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM 3sala m
initial concentration: 1.0
is: C00606
is: CHEBI:61085
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: 3-sulfino-L-alanine (1-)
is: SBO:0000247

metaR S6TASE8ly
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000176

metaR NDPK7
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dCDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true

metaR CEPTC
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is: SBO:0000176
name: choline phosphotransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.2
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#

metaR r0616
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110040#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_785ef19c_0b81_4ed9_8cc0_0eee93050a20
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q5DSZ6
initial amount: NaN
name: UGT1A8
is encoded by: hsa:54576
type: Species
constant: false
is: SBO:0000252

metaM nrpphr c
is: CHEBI:33569
has only substance units: false
type: Species
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: Norepinephrine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_e97c00a9_5333_4828_8e54_66591369386b
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: O00483
is encoded by: hsa:4697
type: Species
has only substance units: false
initial amount: NaN
name: NDUFA4

http://identifiers.org/biomodels.db/MODEL1310110040#_f1e11b15_9c74_4d28_80eb_8576178e0c24
constant: false
is: SBO:0000297
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4830
name: NME1:NME2
has only substance units: false

metaR AICARte
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: true
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

metaR r2128
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110040#
reversible: true
fast: false
product: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR NDPK6
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_ce622bb0_1ed0_468c_af66_6dbe77d4111e
is: SBO:0000252
name: _N63787_1_c
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:N63787
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_f7f59a96_b4f4_4a73_b3ef_87db18d7bb62
has only substance units: false
constant: false
is encoded by: hsa:D29675
name: _D29675_1_c
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_e317c797_b975_467f_b676_350bc31f0544
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10195
name: ALG3
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_d1ede5b5_b9da_44dc_bf5b_024f0a4747e8
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: _AU149534_1_e
is: SBO:0000252
type: Species
is encoded by: hsa:AU149534
initial concentration: NaN

metaR SPHS1Ptr
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
kinetic law: MODEL1310110040#
name: sphingosine-1-phosphate transport
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3c27d577_f465_43e5_85bc_882163ecd53a
boundary condition: true
is: P28331
constant: false
has only substance units: false
is encoded by: hsa:4719
is: SBO:0000252
initial amount: NaN
type: Species
name: NDUFS1
initial concentration: NaN

metaR 1PPDCRp
fast: false
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal

http://identifiers.org/biomodels.db/MODEL1310110040#_58782325_e243_43de_8035_3e4133cd397c
name: PIGN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:23556
is: O95427

metaM ile L c
is: HMDB00172
is: CHEBI:17191
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: L-isoleucine
constant: false
has only substance units: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR NDPK5
modifier: MODEL1310110040#
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110040#

metaM sphings c
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: sphingosine(1+)
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
constant: false
is: CHEBI:57756
is: HMDB00252

metaM cs e l
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:36005
type: Species
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
boundary condition: false
is: SBO:0000247
is: HMDB02183
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
has only substance units: false

metaM c81coa c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C05276
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
name: octenoylcoa
initial amount: NaN
is: HMDB03949
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9f12f967_c6f9_4a71_b1f9_ed5f19d7a567
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:10786
name: SLC17A3
initial concentration: NaN
initial amount: NaN
is: O00476
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_a40cef35_5592_4daa_b24b_df997e37c371
is: Q15392
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DHCR24
type: Species
is encoded by: hsa:1718
is: SBO:0000252
boundary condition: true
constant: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR r0614
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110040#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reactant: MODEL1310110040#
is described by: ECO:0000000

metaR GUAt
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: Guanine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000185

metaM malcoa r
is: HMDB01175
type: Species
boundary condition: false
initial amount: NaN
constant: false
name: malonyl-CoA(4-)
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM ksii core4 e
boundary condition: false
name: keratan sulfate II (core 4-linked)
is: CHEBI:17268
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00211
type: Species
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_67c8b38e_5623_4a1f_8523_0430fe1fae72
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1351
type: Species
is: Q53XN1
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: COX8A

metaM 56dura c
type: Species
has only substance units: false
is: CHEBI:15901
is: SBO:0000247
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076
name: 5,6-dihydrouracil
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r1177
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
fast: false
name: EC:3.1.1.13
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaR C6DCe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of adipoyl carnitine into the extra cellular fluid
type: Reaction

metaM 3hibutcoa m
type: Species
is: SBO:0000247
is: CHEBI:28259
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxyisobutyryl-CoA
constant: false
is: HMDB01052

metaR PE HStm
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: phosphatidylethanolamine scramblase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110040#

metaM 44mzym r
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: CHEBI:18364
is: HMDB01286
initial amount: NaN
name: 14-demethyllanosterol
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR 2MB2COAc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM ksi deg18 l
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
boundary condition: false
type: Species
is: HMDB00143
name: keratan sulfate I, degradation product 18
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:12936
has only substance units: false
initial amount: NaN
constant: false

metaR NDPK3m
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR NDPK4
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:dTDP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction
modifier: MODEL1310110040#

metaR NACHEX24ly
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110040#_856c6085_b79a_4a7d_827d_a0e9772790e5
is: Q8NB10
boundary condition: true
type: Species
is encoded by: hsa:5137
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PDE1C
initial amount: NaN

metaM ile L e
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: L-isoleucine
is: CHEBI:17191
is: SBO:0000247
is: HMDB00172

http://identifiers.org/biomodels.db/MODEL1310110040#_cc1d3a3c_1b26_4284_add7_a7c457efac98
initial concentration: NaN
type: Species
initial amount: NaN
is: P19404
name: NDUFV2
is encoded by: hsa:4729
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR RE1807C
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
name: RE1807
kinetic law: MODEL1310110040#
is: SBO:0000176

metaR RETH1e
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000176
name: retinyl ester hydrolase (9-cis), extracellular
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110040#

metaR C162ACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR r0780
is: SBO:0000176
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b618a0c2_b3af_40d3_82b2_69ab308ecbeb
type: Species
is: Q96RV2
initial amount: NaN
boundary condition: true
name: HAS3
has only substance units: false
is encoded by: hsa:3038
constant: false
is: SBO:0000252
initial concentration: NaN

metaM hpdcacoa c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: heptadecanoyl coa
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial amount: NaN
is: SBO:0000247
is: HMDB06497

metaM cmp g
boundary condition: false
name: CMP(2-)
is: HMDB00095
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
has only substance units: false
is: CHEBI:60377

metaM gdpfuc g
is: HMDB01095
type: Species
name: GDP-L-fucose(2-)
initial amount: NaN
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaM tdchola c
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:9407
has only substance units: false
is: SBO:0000247
is: HMDB00951
name: taurochenodeoxycholate
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_b3840892_5fed_459b_8edb_de7a9e12cec4
initial amount: NaN
name: CROT
is: E7EQF2
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:54677
boundary condition: true
type: Species
initial concentration: NaN

metaM adrn c
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: adrenic acid
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:53487
is: HMDB02226

metaR r0781
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110040#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR DOLDPP Ler
is version of: http://identifiers.org/ec-code/3.6.1.43
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_4fb27fb4_96df_4489_8ebf_ddc72a396f4f
initial amount: NaN
has only substance units: false
boundary condition: true
has part: Q9P2X0
is: SBO:0000297
type: Species
constant: false
initial concentration: NaN
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
is encoded by: hsa:54344

metaM lnlncgcoa m
is: HMDB06368
initial concentration: 1.0
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57363

metaM utp c
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP
is: C00075
is: CHEBI:46398
is: HMDB00285
initial concentration: 1.0
initial amount: NaN

metaR SQLEr
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.132
is: SBO:0000176
modifier: MODEL1310110040#
is described by: ECO:0000134
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#

metaR G6PPer
is: SBO:0000176
product: MODEL1310110040#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.9
name: glucose-6-phosphate phosphatase, edoplasmic reticular
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
modifier: MODEL1310110040#

metaR r2139
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110040#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_4da101da_2510_4e20_bfcb_c5c55ab0ebb7
is encoded by: hsa:9091
type: Species
is: SBO:0000252
initial amount: NaN
name: PIGQ
constant: false
is: B2RAU6
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM bildglcur r
boundary condition: false
name: bis(beta-glucosyluronate)bilirubin
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58471

http://identifiers.org/biomodels.db/MODEL1310110040#_86cf671d_28a1_4978_8716_a5f3322eb0af
type: Species
initial concentration: NaN
initial amount: NaN
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d5ae7866_19b7_45d1_b1c1_5727a162764e
name: PFKL
is encoded by: hsa:5211
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P17858
is: SBO:0000252
initial concentration: NaN

metaM xoltetrol c
is: HMDB01231
type: Species
is: CHEBI:17278
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c05c3631_c900_4f9c_9d10_dd8ef7adb0bb
initial amount: NaN
is: P23786
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:1376
is: SBO:0000252
name: CPT2
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_b9246b83_700e_4574_876f_8aa87f93b13a
type: Species
is encoded by: hsa:6487
name: ST3GAL3
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaM itp e
boundary condition: false
is: HMDB00189
type: Species
initial concentration: 1.0
is: CHEBI:57614
is: SBO:0000247
initial amount: NaN
name: ITP(3-)
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false

metaR S6TASE1ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110040#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110040#

metaR RE3568C
is: SBO:0000176
name: RE3568
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#

metaR RE1519M
type: Reaction
modifier: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1519
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110040#

metaR MERCPLACCYSt
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular

metaR r2136
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
modifier: MODEL1310110040#
fast: false
reversible: false
kinetic law: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

metaM apoC c
initial concentration: 1.0
is: SBO:0000247
is: HMDB11111
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
boundary condition: false
constant: false
is: CHEBI:33190
name: Apocarboxlase (no lys residue)
has only substance units: false
type: Species

metaR ST8SIA52g
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176

metaM pdx5p c
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
has only substance units: false
is: HMDB01319
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58589
type: Species
is: C00627
constant: false
name: Pyridoxine 5'-phosphate
initial amount: NaN
boundary condition: false

metaM 3thexddcoa m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
name: 3-hydroxy trans7,10-hexadecadienoylcoa
initial amount: NaN
boundary condition: false
is: HMDB02014
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM tdchola e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:9407
is: SBO:0000247
is: HMDB00951
has only substance units: false
name: taurochenodeoxycholate
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_53ea77a9_e1a8_4cb1_9e22_374a96f13af4
type: Species
name: GLUL
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P15104
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2752

metaR LALDO2x
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
is described by: ECO:0000269
reactant: MODEL1310110040#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
reversible: false
fast: false
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#

metaM adrn e
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:53487
boundary condition: false
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
is: HMDB02226
has only substance units: false
name: adrenic acid

metaR DOLMANP Uter
product: MODEL1310110040#
is: SBO:0000185
reversible: false
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r2137
is described by: ECO:0000000
modifier: MODEL1310110040#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185

metaM HC02217 c
name: prostaglandin-g2
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
initial concentration: 1.0
is: CHEBI:27647

metaM dca r
boundary condition: false
initial concentration: 1.0
is: HMDB00791
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Decanoate (n-C10:0)
notes: FORMULA: C10H19O2 CHARGE: -1
is: C02838

metaM srtn c
initial amount: NaN
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
is: HMDB00259
boundary condition: false
type: Species
constant: false
name: serotonin(1+)
has only substance units: false
initial concentration: 1.0
is: CHEBI:350546

metaR DCYTt
is: SBO:0000185
reversible: true
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxycytidine transport via diffusion
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction

metaM CE0785 m
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
boundary condition: false
is: CHEBI:57795
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: cis,cis-myristo-5,8-dienoyl-CoA

metaM ksii core4 l
is: SBO:0000247
boundary condition: false
is: CHEBI:57614
initial concentration: 1.0
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
has only substance units: false
is: HMDB00189
type: Species
constant: false
initial amount: NaN
name: keratan sulfate II (core 4-linked)

http://identifiers.org/biomodels.db/MODEL1310110040#_e1c54648_8f9c_4c33_8ca5_4d83d1df936b
is: Q6I9V5
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC25A6
is encoded by: hsa:293
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM g6p c
is: SBO:0000247
name: D-Glucose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:61548
type: Species
is: C00092

metaR EX decdicrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaR MI1345PP
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110040#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
modifier: MODEL1310110040#

metaR PROt2r
name: L-proline reversible transport via proton symport
type: Reaction
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#

metaM C05965 e
constant: false
is: SBO:0000247
type: Species
name: 12(S)-HPETE(1-)
is: CHEBI:57444
is: HMDB04243
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
has only substance units: false
initial amount: NaN

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM ksi deg31 l
name: keratan sulfate I, degradation product 31
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01354
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110040#_7122d77f_e8e1_4279_a366_7a1444694661
is: SBO:0000252
initial concentration: NaN
name: CA13
constant: false
initial amount: NaN
is: Q8N1Q1
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:377677

metaR THFtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false

metaM gdpfuc c
has only substance units: false
type: Species
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: CHEBI:57984
is: SBO:0000247
name: GDP-L-fucose(2-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01095
constant: false

metaM r1p c
name: alpha-D-Ribose 1-phosphate
is: CHEBI:57720
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial amount: NaN
is: HMDB01489
constant: false
is: C00442

metaR 2DR1PP
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: false
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
is: SBO:0000176
type: Reaction
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_2f3e6a13_cc41_4191_821e_99d0e1cc8c28
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: _22305_1_c
is: SBO:0000252
is encoded by: hsa:22305
type: Species

metaR 5HOXINDACTO2OX
is described by: ECO:0000304
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
product: MODEL1310110040#
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.3.1

http://identifiers.org/biomodels.db/MODEL1310110040#_e253e64c_dc44_46b8_b9e2_812e9880d520
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AI934540_1_c
constant: false
is encoded by: hsa:AI934540
type: Species
boundary condition: true
initial amount: NaN

metaR DNDPt28m
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dGDP antiport
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110040#

metaM ppa m
constant: false
is: HMDB00237
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
name: propionate
type: Species
is: CHEBI:17272

http://identifiers.org/biomodels.db/MODEL1310110040#_263e8bde_cca3_47da_94e5_c2394969312e
is: Q8IUC8
has only substance units: false
initial concentration: NaN
name: GALNT13
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:114805

http://identifiers.org/biomodels.db/MODEL1310110040#_11b40ef8_6b09_4381_b34b_432a5121aa40
is encoded by: hsa:7084
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is: O00142
name: TK2

metaR CYTD
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: cytidine deaminase
type: Reaction
product: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_6460d6c2_15b6_4579_8bef_c5c5256f81f3
is: SBO:0000297
has only substance units: false
is encoded by: hsa:4967
name: DLD:DLST:OGDH:PDHX
constant: false
has part: Q02218
is encoded by: hsa:1738
has part: P36957
has part: O00330
has part: P09622
is encoded by: hsa:1743
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:8050
initial amount: NaN

metaR FAOXC162C162OHm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM srtn e
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: serotonin(1+)
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00259

http://identifiers.org/biomodels.db/MODEL1310110040#_b1be48c6_c7ab_4a26_82f4_8fd0c45cb111
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:5298
is: Q9UBF8
name: PI4KB

metaM xoltri25 e
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1
boundary condition: false
is: HMDB06280
has only substance units: false
is: CHEBI:37623
type: Species
name: 7alpha,25-dihydroxycholesterol

metaM 3sala c
is: CHEBI:61085
is: SBO:0000247
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
name: 3-Sulfino-L-alanine
type: Species
initial concentration: 1.0
constant: false
is: C00606
boundary condition: false
initial amount: NaN
has only substance units: false

metaM cs a deg2 l
has only substance units: false
type: Species
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00127
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
constant: false
is: SBO:0000247
is: CHEBI:15748

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00673
name: linoleate
is: CHEBI:30245
boundary condition: false
constant: false
is: SBO:0000247

metaR r2132
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true

metaR CYTK11n
is described by: ECO:0000269
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
fast: false
name: cytidylate kinase (dCMP,dGTP),nuclear
type: Reaction
kinetic law: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110040#

metaM cmp m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
name: CMP(2-)
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:60377

metaM co2 m
boundary condition: false
is: CHEBI:16526
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
name: CO2
constant: false
type: Species
is: HMDB01967
is: SBO:0000247
has only substance units: false

metaR Q10H2e
product: MODEL1310110040#
is described by: ECO:0000134
reversible: true
fast: false
type: Reaction
name: transport of ubiquinol into lymph
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_98d68293_0514_4c1e_bde6_431f170457a1
is: B3KVI7
constant: false
name: IVD
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3712
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b7295055_cb3e_4b5d_93c1_c99e958e3d15
constant: false
initial amount: NaN
name: PANK2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_4ba33225_2ba3_485a_a007_844a74a537a5
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q99685
is: SBO:0000252
name: MGLL
is encoded by: hsa:11343
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_28b9f3c8_530e_4836_87c3_7495eabfea8f
constant: false
is: SBO:0000252
is encoded by: hsa:56301
initial concentration: NaN
boundary condition: true
name: SLC7A10
has only substance units: false
is: Q9NS82
type: Species
initial amount: NaN

metaM alpro m
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
initial concentration: 1.0
type: Species
is: CHEBI:16882
name: S-Aminomethyldihydrolipoylprotein
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_54421e1b_89a7_4f86_9e87_aa67db754139
has only substance units: false
initial amount: NaN
is encoded by: hsa:6487
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: ST3GAL3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_eb8f865c_44b0_409e_8350_ca9155ab2321
has only substance units: false
is encoded by: hsa:3945
is: P07195
name: LDHB
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_a26f8e60_4430_4bf1_9df4_4ad154c9ddc0
is encoded by: hsa:30
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q96CA6
has only substance units: false
name: ACAA1
constant: false

metaM ala B m
constant: false
initial concentration: 1.0
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
is: HMDB00056
is: CHEBI:16958
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_1d9ff26c_ebb4_4045_b97e_21716c1b8467
is encoded by: hsa:26289
is: Q9Y6K8
has only substance units: false
type: Species
constant: false
initial concentration: NaN
name: AK5
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM cmp n
boundary condition: false
initial concentration: 1.0
name: CMP(2-)
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:60377
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095

http://identifiers.org/biomodels.db/MODEL1310110040#_6bf552e5_5676_4e6b_bfa1_bc4b9a5ff4c5
initial amount: NaN
boundary condition: true
type: Species
is: Q14032
is encoded by: hsa:570
initial concentration: NaN
constant: false
name: BAAT
is: SBO:0000252
has only substance units: false

metaM oxa m
boundary condition: false
type: Species
is: CHEBI:30623
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
constant: false
name: oxalate(2-)
is: SBO:0000247
is: HMDB02329
initial concentration: 1.0

metaM xoltri25 c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB06280
name: 7alpha,25-dihydroxycholesterol
is: CHEBI:37623
type: Species

metaM utp e
type: Species
initial concentration: 1.0
name: UTP(4-)
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: CHEBI:46398
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00285

metaR ACACT1rm
fast: false
modifier: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a44d50ce_4214_4600_88a5_af0ad9bb20d7
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC5A3
type: Species
initial amount: NaN
is encoded by: hsa:6526
constant: false
is: P53794
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_7c955a7d_6ecf_4994_a093_206c2cf0c89f
name: DPM1
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: O60762
has only substance units: false
is encoded by: hsa:8813
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_99ae0ef3_8498_4c60_a7b1_a12295e6c97b
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC5A2
is: P31639
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6524

metaR r2133
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM tsul c
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00257
is: CHEBI:16094
name: thiosulfate(2-)
has only substance units: false

metaR r0909
is: SBO:0000185
fast: false
name: Transport reaction
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#

metaR r1418
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_5d879d5b_9573_45b8_bd48_25a95a10c4c4
is: SBO:0000252
constant: false
name: ATP5L
is: O75964
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10632

metaR FAOXC16OHC16r
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM glcur c
type: Species
name: D-glucuronate
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b4264502_2fac_4b82_a1bf_cfbbcc8fb96d
name: SLC27A3
is: SBO:0000252
initial concentration: NaN
is: Q5K4L6
has only substance units: false
is encoded by: hsa:11000
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR SPHS1Pte
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is: SBO:0000185
name: sphingosine-1-phosphate transport
kinetic law: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction

metaM octdececoa c
initial amount: NaN
boundary condition: false
name: octadecenoylcoa
type: Species
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: HMDB06351
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d80fe661_23c9_422e_89ee_6ccc2259857d
constant: false
is: P04843
type: Species
name: RPN1
boundary condition: true
is encoded by: hsa:6184
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM ahcys m
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
is: HMDB00939
boundary condition: false
type: Species
is: C00021
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
is: CHEBI:16680
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7e47248e_58bb_4dd4_9513_ae8405b8669a
constant: false
type: Species
is: Q96KH8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6530
name: SLC6A2
has only substance units: false

metaR r2130
is described by: ECO:0000000
product: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110040#

metaR r0788
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110040#

metaM xoltri25 r
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1
type: Species
is: CHEBI:37623
is: SBO:0000247
is: HMDB06280
name: 7alpha,25-dihydroxycholesterol
initial concentration: 1.0
constant: false
boundary condition: false

metaR SERDGLNexR
type: Reaction
fast: false
name: D-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaM CE2435 m
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57795
has only substance units: false
boundary condition: false
name: trans,cis-deca-2,4-dienoyl-CoA
constant: false

metaM aps c
is: HMDB01003
is: CHEBI:58243
type: Species
name: 5'-adenylyl sulfate(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
has only substance units: false
constant: false

metaR CYTK7n
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_f3c93e0b_53b9_4570_afae_2bf9c84e9066
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1607
initial concentration: NaN
name: DGKB

http://identifiers.org/biomodels.db/MODEL1310110040#_d6c2cdb2_082c_4635_a76a_abdd0cd69715
name: SUCLA2
initial amount: NaN
is encoded by: hsa:8803
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: E5KS60
initial concentration: NaN

metaR PIter
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110040#
name: phosphate transport, endoplasmic reticulum
type: Reaction
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reactant: MODEL1310110040#
fast: false

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaM HC01403 m
name: (S)-Hydroxydecanoyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: CHEBI:28325
initial amount: NaN
type: Species

metaR ADRNt
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#

metaM od2coa c
name: trans-Octadec-2-enoyl-CoA
type: Species
is: C16218
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06529
is: CHEBI:50570
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_8a2250c7_5469_4f12_a133_e9114105bbe8
is: P15531
type: Species
name: NME1
initial concentration: NaN
constant: false
is encoded by: hsa:4830
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r2131
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110040#
fast: false

metaR r0789
modifier: MODEL1310110040#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_26435bc3_584a_4052_8f1d_febd48f0f3ec
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:522
has only substance units: false
name: ATP5J
initial concentration: NaN

metaR CYSATB0tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cysteine into the intestinal cells by ATB0 transporter
type: Reaction

metaM c226coa m
name: cervonyl coenzyme A
initial concentration: 1.0
boundary condition: false
is: C16169
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
type: Species
is: http://identifiers.org/pubchem.compound/47205479

http://identifiers.org/biomodels.db/MODEL1310110040#_60148ba7_eba5_4893_8274_2450f3c3b001
boundary condition: true
name: GGT7
type: Species
is: SBO:0000252
is encoded by: hsa:2686
initial amount: NaN
constant: false
has only substance units: false
is: A0PJJ9
initial concentration: NaN

metaM cala c
is: CHEBI:11892
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
boundary condition: false
initial amount: NaN
constant: false
name: N-carbamoyl-beta-alaninate
is: SBO:0000247
is: HMDB00026

metaM dlnlcgcrn c
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
has only substance units: false
is: HMDB01311
initial amount: NaN
name: dihomo-gamma-linolenyl carnitine
initial concentration: 1.0
is: CHEBI:16004
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c66aa330_1f65_4c2a_955c_a00159c27dbc
initial amount: NaN
has only substance units: false
is: Q9UHV8
constant: false
is: SBO:0000252
name: LGALS13
boundary condition: true
is encoded by: hsa:29124
type: Species
initial concentration: NaN

metaM 3spyr c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB04045
is: CHEBI:57940
boundary condition: false
name: 3-sulfonatopyruvate(2-)
constant: false
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
has only substance units: false

metaM CE4790 m
is: SBO:0000247
constant: false
type: Species
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial amount: NaN
is: CHEBI:15748
has only substance units: false
initial concentration: 1.0
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110040#_7911252c_645a_4c56_ad1c_1aff64947a30
is: SBO:0000252
name: SOD2
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: P04179
initial concentration: NaN
type: Species
is encoded by: hsa:6648

metaR ILELAT1tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR ADKd
reactant: MODEL1310110040#
is: SBO:0000176
name: adenylate kinase (d form)
product: MODEL1310110040#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
fast: false
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM ocdcea c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: octadecenoate (n-C18:1)
initial amount: NaN
is: CHEBI:0
is: C00712
initial concentration: 1.0
boundary condition: false
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1

metaM lnlncgcoa c
initial concentration: 1.0
is: CHEBI:57363
initial amount: NaN
has only substance units: false
type: Species
is: HMDB06368
is: SBO:0000247
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
name: gamma-linolenoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110040#_1e5a6617_ba31_487b_86ed_1ed816cf72b4
is encoded by: hsa:5332
type: Species
is: Q15147
has only substance units: false
initial amount: NaN
name: PLCB4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR r0787
reversible: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_78db3e11_80b9_4c74_8e6f_52aeb033175c
is: A8K0T6
is: SBO:0000252
initial amount: NaN
name: SMPD3
type: Species
has only substance units: false
is encoded by: hsa:55512
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_62b004a2_fceb_4356_bc7f_e89ab0b1bf7c
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: AADAT
type: Species
is: SBO:0000252
boundary condition: true
is: Q8N5Z0
is encoded by: hsa:51166

metaM gmp n
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
is: SBO:0000247
name: GMP(3-)
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:58115
initial concentration: 1.0
constant: false
type: Species

metaR RE2649C
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
name: RE2649
type: Reaction
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is described by: ECO:0000000

metaM mi1p D n
is: SBO:0000247
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
initial amount: NaN
boundary condition: false
is: CHEBI:58433
initial concentration: 1.0
type: Species
constant: false

metaM ksi pre34 g
is: HMDB00175
is: SBO:0000247
is: C00130
is: CHEBI:58053
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 34
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0f9c4af8_55bf_41dc_8f41_97c01ed2a3d6
constant: false
initial amount: NaN
is: Q9UBM7
name: DHCR7
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:1717

metaR CO2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 peroxisomal transport
reversible: true
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185

metaM itp c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
name: ITP(3-)
initial amount: NaN
is: SBO:0000247
is: HMDB00189
type: Species
boundary condition: false
is: CHEBI:57614

metaR r0784
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176

metaM co2 c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01967
is: CHEBI:3313
notes: FORMULA: CO2 CHARGE: 0
initial amount: NaN
boundary condition: false
name: CO2
is: C00011
is: SBO:0000247

metaM cmp c
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: CMP
is: C00055
boundary condition: false
initial amount: NaN
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_28cbf2cc_aaf2_4619_b708_e762d7443272
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8705
is: B3KQP5
constant: false
name: B3GALT4
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_a79fc7b8_6b80_46b2_bca3_123fdecd1dea
constant: false
initial amount: NaN
boundary condition: true
is: Q7GXZ1
type: Species
has only substance units: false
name: ND6
is encoded by: hsa:4541
initial concentration: NaN
is: SBO:0000252

metaR CSND
name: Cytosine deaminase
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM HC02217 e
is: CHEBI:27647
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
constant: false
name: prostaglandin-g2
is: SBO:0000247
initial concentration: 1.0

metaR C3DCe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_9c184382_aaa5_43c3_ad64_c6462aa32b11
constant: false
is encoded by: hsa:4725
is: SBO:0000252
name: NDUFS5
is: Q6IBA0
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM bildglcur e
constant: false
is: HMDB03325
is: CHEBI:58471
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_cf2e667c_08fc_4edf_8fc0_b54324c68775
type: Species
name: ARSB
initial concentration: NaN
is: P15848
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:411

metaR r1722
modifier: MODEL1310110040#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_5ae716e2_a29c_4c04_a54a_19613788e43a
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6390
is: P21912
name: SDHB
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2b09f89c_83b4_41dc_9616_7bd602fc3cdc
constant: false
type: Species
has only substance units: false
name: AKR1A1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10327

metaR RDH1a
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.300
reversible: true
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110040#
is: SBO:0000176
name: retinol dehydrogenase (all-trans,NADPH)
type: Reaction

metaR TYMSULT
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
reactant: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
modifier: MODEL1310110040#
name: Tyramine Sulfotransferase
fast: false
product: MODEL1310110040#
reversible: false

metaM glcur e
initial amount: NaN
name: D-glucuronate
is: CHEBI:15748
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: HMDB00127
type: Species
boundary condition: false
constant: false

metaR LAPCOAl
fast: false
reversible: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
modifier: MODEL1310110040#
name: lysosomal acid phosphorylase (CoA)

metaR CO2tm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
type: Reaction
is: SBO:0000185

metaM ala B e
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: beta-alanine
initial amount: NaN
is: HMDB00056
is: CHEBI:16958
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR LEUTA
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: leucine transaminase
reversible: true
fast: false
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is described by: ECO:0000269

metaM ctp m
boundary condition: false
is: CHEBI:37563
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
name: CTP(4-)
has only substance units: false
initial concentration: 1.0
is: HMDB00082

metaM utp n
type: Species
name: UTP(4-)
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: HMDB00285
is: CHEBI:46398
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM 3ohdcoa x
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
constant: false
type: Species
name: 3-oxopalmitoyl-CoA(4-)
initial amount: NaN
is: HMDB06402
is: CHEBI:57349

metaM gt1c hs g
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: GT1c
has only substance units: false
type: Species
is: CHEBI:28648
is: SBO:0000247
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3

metaM co2 e
constant: false
type: Species
is: HMDB01967
has only substance units: false
is: CHEBI:16526
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00011
is: SBO:0000247
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaM cmp e
name: CMP(2-)
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:60377
boundary condition: false
is: SBO:0000247
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM ctp n
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
has only substance units: false
is: CHEBI:37563
initial concentration: 1.0
type: Species
constant: false
name: CTP(4-)
is: HMDB00082

metaR ST8SIA12
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.99.8
reversible: false
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase

http://identifiers.org/biomodels.db/MODEL1310110040#_52685418_2d2e_4b7a_aff1_f59830fa0dc5
initial concentration: NaN
initial amount: NaN
is: O43252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:9061
is: SBO:0000252
name: PAPSS1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_91af9328_33dc_4d88_90e4_fa52ad568e9f
initial concentration: NaN
name: ACAT1
is: SBO:0000252
is encoded by: hsa:38
initial amount: NaN
type: Species
constant: false
is: P24752
boundary condition: true
has only substance units: false

metaR SGPL12r
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000304
fast: false
is: SBO:0000176
product: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
name: Sphingosine-1-phosphate lyase
reversible: false

metaR r0908
name: Postulated transport reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
is: SBO:0000185
type: Reaction

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r0783
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
type: Reaction
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_5b2caee4_f90a_4f1b_a139_6126ac5e6c0f
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:51251
name: NT5C3
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9H0P0
initial amount: NaN

metaR LINKDEG1ly
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false

metaR ICDHyrm
modifier: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
fast: false
is: SBO:0000176
name: Isocitrate dehydrogenase (NADP+)
type: Reaction
reactant: MODEL1310110040#

metaR S6T2g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_fceecc2f_8cd6_4b8d_a090_032c90a6b7f5
is: SBO:0000252
name: SLC35D2
is: Q76EJ3
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:11046

metaM mi1p D c
initial amount: NaN
is: CHEBI:58433
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
is: HMDB02985
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

http://identifiers.org/biomodels.db/MODEL1310110040#_9537e10a_730c_4a2b_8636_03c82278ff91
initial amount: NaN
type: Species
has only substance units: false
is: Q9BRB3
name: PIGQ
boundary condition: true
is encoded by: hsa:9091
initial concentration: NaN
is: SBO:0000252
constant: false

metaR AG13T6g
is described by: ECO:0000000
product: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaM ksii core2 pre10 g
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 10
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: CHEBI:28067

metaM co2 x
is: CHEBI:16526
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: carbon dioxide
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_1912083a_c50b_4a7e_818d_eaf0e3df192e
initial amount: NaN
has only substance units: false
is encoded by: hsa:4522
boundary condition: true
type: Species
initial concentration: NaN
is: P11586
name: MTHFD1
constant: false
is: SBO:0000252

metaM xu5p D c
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57737
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
has only substance units: false
name: D-xylulose 5-phosphate(2-)
initial concentration: 1.0
type: Species
is: HMDB00868

metaR VALTA
name: valine transaminase
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
product: MODEL1310110040#
fast: false

metaR r0758
type: Reaction
reactant: MODEL1310110040#
fast: false
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:
product: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000000

metaR MMEm
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: true
name: methylmalonyl-CoA epimerase/racemase
is version of: http://identifiers.org/ec-code/5.1.99.1
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false

metaR H2MTer L
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
name: H2 mannosyltransferase, endoplasmic reticulum
reversible: false
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM glcur l
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
has only substance units: false
is: HMDB00127
name: D-glucuronate

metaM ahcys e
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: C00021
constant: false
has only substance units: false
is: HMDB00939
type: Species
is: CHEBI:16680
initial amount: NaN
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR DNDPt55m
name: dCTP transport via ADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110040#

metaM dhcholestanate m
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b72b3ba3_1382_4091_aa26_2fa61fb54f08
is encoded by: hsa:23530
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: NNT
boundary condition: true
constant: false
is: Q13423
initial concentration: NaN

metaM od2coa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
constant: false
boundary condition: false
name: trans-Octadec-2-enoyl-CoA
is: SBO:0000247
has only substance units: false
is: CHEBI:50570
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB06529

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM tsul m
is: HMDB00257
boundary condition: false
name: thiosulfate(2-)
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16094
type: Species

metaR r0355
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
reactant: MODEL1310110040#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110040#
is described by: ECO:0000000
fast: false

metaR C161CRNt
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
name: C161 transport into the mitochondria
is: SBO:0000185
modifier: MODEL1310110040#
fast: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_3be72998_03b3_4d3c_8266_62e1c0cd0cdf
initial amount: NaN
type: Species
is encoded by: hsa:5279
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: PIGC
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_df8db157_593a_4cbd_a767_def33ef017e3
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:80025
is: Q9BZ23
name: PANK2
initial amount: NaN
type: Species
boundary condition: true

metaM HC02202 c
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: prostaglandin A1(1-)
type: Species
is: CHEBI:57398
constant: false

metaR DM gpi sig er
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_69495a50_dded_4c6d_9ac5_249b2bcd73a0
initial amount: NaN
name: DCK
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1633
is: SBO:0000252
initial concentration: NaN
is: P27707
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_44187e48_3ee4_48dc_9bec_bdc373accb29
type: Species
constant: false
is: Q9NPH0
is: SBO:0000252
is encoded by: hsa:51205
initial concentration: NaN
name: ACP6
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r0354
reactant: MODEL1310110040#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM cspg b l
boundary condition: false
type: Species
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
has only substance units: false
is: HMDB02183
is: SBO:0000247
initial concentration: 1.0

metaR AG13T17g
modifier: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110040#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#

metaM ksi deg20 l
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 20

metaM ivcoa c
name: Isovaleryl-CoA
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
is: HMDB01113
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_11211ef1_afd7_4b00_8b08_9b76fa903754
name: PSAT1
initial amount: NaN
has only substance units: false
is encoded by: hsa:29968
constant: false
is: Q9Y617
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR NDPK6n
product: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
fast: false

metaM ctp c
is: SBO:0000247
type: Species
is: HMDB00082
constant: false
initial amount: NaN
has only substance units: false
is: C00063
initial concentration: 1.0
name: CTP
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c644d536_a136_499f_9b74_3c21b99b9cf5
name: SDHD
initial amount: NaN
is encoded by: hsa:6392
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: O14521

metaR r0755
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110040#

metaR ACACT4p
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
modifier: MODEL1310110040#
reversible: false
fast: false
reactant: MODEL1310110040#
name: acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaM dutp m
name: dUTP
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:17625
boundary condition: false
type: Species

metaR CERT1gt
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110040#_a6aeeebb_b6c7_456a_beb6_a9a55fd4c45e
has only substance units: false
is: SBO:0000252
name: IMPA2
type: Species
is encoded by: hsa:3613
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: O14732

http://identifiers.org/biomodels.db/MODEL1310110040#_7b0d024e_1d2c_4fcb_9f46_e843514afee4
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: SLC7A9
initial concentration: NaN
is: SBO:0000252
is: P82251
has only substance units: false
is encoded by: hsa:11136

metaM ksi deg16 l
is: HMDB01354
type: Species
name: keratan sulfate I, degradation product 16
is: SBO:0000247
initial amount: NaN
is: CHEBI:57455
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM glu5sa m
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C01165
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
name: L-Glutamate 5-semialdehyde
is: HMDB02104
is: CHEBI:17232

metaM dutp n
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
constant: false
initial concentration: 1.0
name: dUTP
initial amount: NaN
is: SBO:0000247
is: CHEBI:17625
has only substance units: false

metaR PTCRTD
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
name: diffusion of putriscine into the endothelial cells
reversible: true
fast: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110040#_c5fa480e_9914_489e_8693_0480619792ef
initial amount: NaN
is: Q96QD8
initial concentration: NaN
constant: false
name: SLC38A2
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:54407

http://identifiers.org/biomodels.db/MODEL1310110040#_79cd15c9_6498_42ea_9f3a_450df0be87f9
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P04745
is encoded by: hsa:278
has only substance units: false
initial concentration: NaN
boundary condition: true
name: AMY1C

metaM HC02202 e
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_01959535_d1eb_45ba_b933_1238d37b4ffa
is encoded by: hsa:37
is: P49748
name: ACADVL
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaM ksii core4 pre3 g
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: C00130
is: CHEBI:58053
notes: FORMULA: C55H89N5O38X CHARGE: -1

metaM dlnlcgcrn m
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
boundary condition: false
is: SBO:0000247
is: HMDB01311
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16004
name: dihomo-gamma-linolenyl carnitine
constant: false

metaM ddece1crn e
name: dodecenoyl carnitine
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
constant: false
boundary condition: false
is: HMDB02250

metaR r0754
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110040#_753dbd31_905f_4755_b95a_b0e5d06a682c
name: _AI824319_1_r
is encoded by: hsa:AI824319
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3a14447f_73c1_4c32_ab07_a759ca5f0727
is: SBO:0000297
is encoded by: hsa:5211
initial concentration: NaN
constant: false
name: PFKL:PFKP
type: Species
has part: Q7L2M7
initial amount: NaN
has only substance units: false
boundary condition: true

metaM pail5p hs n
is: CHEBI:57795
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110040#_36f6962e_eaea_4c31_aa15_0fa8f2e1698b
initial amount: NaN
name: NDUFC2
is encoded by: hsa:4718
has only substance units: false
is: Q549M5
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_3ed9d60f_2ec6_4624_bacf_f1b100916552
initial concentration: NaN
is: Q9NVE7
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:55229
name: PANK4
has only substance units: false
is: SBO:0000252

metaM dca c
initial concentration: 1.0
is: C02838
is: HMDB00791
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Decanoate (n-C10:0)
constant: false
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1

metaR DCK2n
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: Deoxycytidine kinase, nuclear (UTP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR CITtam
reversible: true
type: Reaction
modifier: MODEL1310110040#
fast: false
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: citrate transport, mitochondrial

metaR PRO Dtde
fast: false
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110040#
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110040#
reactant: MODEL1310110040#

metaM ctp e
type: Species
is: HMDB00082
boundary condition: false
constant: false
initial amount: NaN
name: CTP(4-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:37563
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

http://identifiers.org/biomodels.db/MODEL1310110040#_7a24af4c_ce5d_4bdb_a0bd_ab43a3a2a6e0
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: DGKZ
has only substance units: false
is: B7Z6M3
initial concentration: NaN
type: Species
is encoded by: hsa:8525
constant: false

metaM ksi pre15 g
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 15
type: Species
is: CHEBI:58053
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: HMDB00175
has only substance units: false
initial amount: NaN
is: C00130
initial concentration: 1.0
boundary condition: false

metaR MDH
reactant: MODEL1310110040#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110040#
reversible: true
name: malate dehydrogenase
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
type: Reaction
product: MODEL1310110040#

metaR r0779
fast: false
kinetic law: MODEL1310110040#
reversible: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110040#_d36d9429_b6a3_4846_972d_61652f857e42
boundary condition: true
type: Species
is: O15269
initial concentration: NaN
name: SPTLC1
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10558

http://identifiers.org/biomodels.db/MODEL1310110040#_5ee3116b_457b_4597_ab7e_cf1e262ae66e
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:53905
constant: false
name: DUOX1
boundary condition: true
is: SBO:0000252

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR CYTK6n
type: Reaction
reversible: true
name: cytidylate kinase (CMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
modifier: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR NACDe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM ddece1crn c
boundary condition: false
initial concentration: 1.0
is: HMDB03712
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C19H35NO4 CHARGE: 0
type: Species
is: SBO:0000247
name: dodecenoyl carnitine

metaR FDH
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000304
reversible: false
type: Reaction
name: formate dehydrogenase
kinetic law: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.6
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (10840.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.2.1.2 Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR RE3242R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reversible: true
is described by: ECO:0000000
name: RE3242
is: SBO:0000176
type: Reaction
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_c35f4426_1aeb_416d_ad10_839ca13ab872
constant: false
name: IDUA
has only substance units: false
is: P35475
is encoded by: hsa:3425
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM ahcys c
initial amount: NaN
is: C00021
constant: false
is: HMDB00939
is: CHEBI:16680
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
has only substance units: false

metaR CYSO
name: cysteine oxidase
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT

metaM 34dhoxmand m
is: HMDB01866
is: CHEBI:27637
is: SBO:0000247
type: Species
name: 3,4-Dihydroxymandelate
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

metaR NDPK6m
is described by: ECO:0000254
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reversible: true
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM hs deg14 l
boundary condition: false
name: heparan sulfate, degradation product 14
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16126
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
constant: false

metaR RE1254C
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reversible: true
type: Reaction
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000176
name: RE1254

metaR THD1m
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
reversible: true
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.6.1.2
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110040#
name: NAD(P) transhydrogenase

metaM dca e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: Decanoate (n-C10:0)
type: Species
is: C02838
is: HMDB00791
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110040#_fff410ed_1672_41a8_b124_b317a8af93a9
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q01581
is encoded by: hsa:3157
constant: false
initial concentration: NaN
name: HMGCS1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_28722a2e_049f_4618_81d2_34603be97e9f
is encoded by: hsa:6713
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: SQLE
constant: false
is: Q5HYI4
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d1f1a218_4f15_49d7_9bb7_94feb7b51bd1
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
boundary condition: true
has only substance units: false
name: _HG2846_HT2983_1_m

http://identifiers.org/biomodels.db/MODEL1310110040#_2630af3f_d55b_40a1_b816_fb384d5f2f0e
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:2585
name: GALK2
initial concentration: NaN
initial amount: NaN
constant: false

metaR PRODt2r
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
is described by: ECO:0000304
name: D-proline reversible transport via proton symport
fast: false
reactant: MODEL1310110040#

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_940a70e7_1508_455e_93ee_533731a3ec21
name: SLC25A19
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q9HC21
constant: false
boundary condition: true
is encoded by: hsa:60386

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR NDPK2n
is described by: ECO:0000269
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
type: Reaction
fast: false
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110040#_bdc3f926_fc77_49c8_87a6_3b49d5260f76
name: ENPP3
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: Q308M7
initial amount: NaN
is encoded by: hsa:5169
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_f197da14_cc80_4c33_a62d_e410bc586336
is: P07954
is: SBO:0000252
has only substance units: false
name: FH
initial concentration: NaN
is encoded by: hsa:2271
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM CE5120 m
is: SBO:0000247
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: HMDB00127
initial amount: NaN
is: CHEBI:15748
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_a84df529_f2d6_448e_8d1d_ebb12650e54f
initial amount: NaN
has only substance units: false
is: O75891
initial concentration: NaN
is encoded by: hsa:10840
name: ALDH1L1
constant: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_4fe0b8fe_5b59_47c7_b6ce_cf1eae8a6e52
type: Species
is encoded by: hsa:F23536
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: _F23536_1_m
initial amount: NaN

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
constant: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
is: CHEBI:16987
has only substance units: false
boundary condition: false
is: HMDB12130
initial amount: NaN
type: Species

metaM 5HPET c
boundary condition: false
initial concentration: 1.0
is: HMDB01193
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
constant: false
name: 5(S)-HPETE(1-)
is: CHEBI:57450

metaR C50CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_f0f24a92_e746_4927_a604_139fe7d7999d
is: Q8N0W3
name: FUK
is encoded by: hsa:197258
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaR GLUVESSEC
is: SBO:0000185
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
name: L-glutamate secretion via secretory vesicle (ATP driven)
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (57084.1) or (246213.1) or (57030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11432869,PMID:12811560,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known stoichiometrically.

http://identifiers.org/biomodels.db/MODEL1310110040#_d4c72d7b_9d06_4616_8cd4_1d4d21599eec
name: NDUFB8
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: O95169
initial amount: NaN
is encoded by: hsa:4714
constant: false

metaM clpn hs c
is: SBO:0000247
has only substance units: false
is: CHEBI:28494
constant: false
name: cardiolipin
type: Species
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM apoC m
type: Species
is: HMDB00182
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: XH CHARGE: 0
constant: false
is: SBO:0000247
name: Apocarboxlase (no lys residue)
is: CHEBI:32551
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_4ebd5892_9d8a_456d_929d_7a16e52f3f19
is encoded by: hsa:4713
is: SBO:0000252
constant: false
has only substance units: false
is: P17568
initial concentration: NaN
boundary condition: true
name: NDUFB7
initial amount: NaN
type: Species

metaM ivcoa m
has only substance units: false
boundary condition: false
is: HMDB01113
name: Isovaleryl-CoA
constant: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: CHEBI:57345
type: Species
initial amount: NaN
is: SBO:0000247

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR ITPtn
name: ITP nuclear transport
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaM co2 r
constant: false
initial amount: NaN
name: CO2
type: Species
is: HMDB01967
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00011

metaM cspg b e
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00630
boundary condition: false
is: CHEBI:16040
has only substance units: false
initial amount: NaN
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6

metaR GLCNACASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
name: alpha-N-acetylglucosaminidase, lysosomal
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110040#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_fa2d3863_7033_417e_83e1_0a6b695039f0
has only substance units: false
initial amount: NaN
is encoded by: hsa:125
is: P00325
boundary condition: true
type: Species
is: SBO:0000252
name: ADH1B
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_06a02eae_3d49_427f_8963_18d4b8c7fd20
constant: false
type: Species
boundary condition: true
has only substance units: false
name: SCD5
is: Q86SK9
initial amount: NaN
is encoded by: hsa:79966
is: SBO:0000252
initial concentration: NaN

metaM itp n
type: Species
is: HMDB00189
is: CHEBI:57614
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
initial concentration: 1.0
name: ITP(3-)
has only substance units: false
constant: false

metaM xol7ah c
type: Species
initial amount: NaN
is: SBO:0000247
name: 7alpha-hydroxy-5beta-cholestan-3-one
has only substance units: false
is: CHEBI:2290
initial concentration: 1.0
is: HMDB06892
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
constant: false
boundary condition: false

metaM dutp c
is: C00460
name: dUTP
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17625

metaM hs l
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28815
is: SBO:0000247
initial amount: NaN
name: heparan sulfate, free chain

metaM nmn c
is: CHEBI:14649
boundary condition: false
name: NMN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
type: Species
is: C00455
initial amount: NaN
has only substance units: false
is: HMDB00229
constant: false

metaR BMTer L
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
name: B mannosyltransferase, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_947b937a_b3c7_4053_9541_95123daa03c0
constant: false
is encoded by: hsa:4707
initial amount: NaN
is: O75438
boundary condition: true
name: NDUFB1
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM 3hmp m
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805

metaM c101crn c
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
boundary condition: false
name: decenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110040#_ee041b96_341a_4aa1_b03a_fc2f183bad07
initial amount: NaN
constant: false
boundary condition: true
name: PIGP
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:51227

http://identifiers.org/biomodels.db/MODEL1310110040#_6c25917a_67da_4834_9b23_12ce53786ab5
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: FOLR1
is encoded by: hsa:2348
type: Species
is: SBO:0000252

metaR PROSTGH2t
is: SBO:0000185
reversible: true
is described by: ECO:0000269
fast: false
name: Prostaglandin H2 transport
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
kinetic law: MODEL1310110040#

metaR GLYt7 311 r
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
is described by: ECO:0000006
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)
type: Reaction
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110040#

metaM cs e deg5 l
constant: false
type: Species
is: HMDB00868
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57737
notes: FORMULA: C31H47NO35S3 CHARGE: -4
has only substance units: false

metaM dhcholestanate x
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00359
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
boundary condition: false
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaM glcur r
initial concentration: 1.0
type: Species
initial amount: NaN
name: D-glucuronate
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
constant: false
is: SBO:0000247
is: HMDB00127
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_cbd7e3c4_9037_404b_871d_9d87bfa7530a
boundary condition: true
is encoded by: hsa:1635
name: DCTD
has only substance units: false
is: P32321
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR RE2649M
product: MODEL1310110040#
modifier: MODEL1310110040#
name: RE2649
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
reversible: true

metaM 10fthf5glu e
type: Species
name: 10-formyltetrahydrofolate-[Glu](5)
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57454
initial amount: NaN
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0
is: HMDB00972
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e0caca36_cdc1_451c_a2ea_924500ac214c
is encoded by: hsa:3156
name: HMGCR
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: P04035
boundary condition: true

metaM ksi pre33 g
constant: false
initial concentration: 1.0
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: HMDB00175
has only substance units: false
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 33
is: CHEBI:58053
boundary condition: false
is: C00130
initial amount: NaN

metaR GALASE5ly
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
type: Reaction
product: MODEL1310110040#
fast: false
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM ksii core2 deg1 l
is: HMDB00868
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
type: Species
initial concentration: 1.0
is: CHEBI:57737
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 1

metaM ppa e
type: Species
is: SBO:0000247
constant: false
is: HMDB00237
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
has only substance units: false
is: CHEBI:17272
name: propionate
boundary condition: false

metaR CSPG Etly
product: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate E transport, extracellular to lysosome
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
type: Reaction

metaR KCCt
name: K+-Cl- cotransport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
modifier: MODEL1310110040#
product: MODEL1310110040#

metaM 3oddcoa x
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
is: CHEBI:27868
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: 3-Oxododecanoyl-CoA
is: SBO:0000247

metaM no c
initial concentration: 1.0
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial amount: NaN
name: Nitric oxide
has only substance units: false
type: Species
is: CHEBI:16480
is: SBO:0000247
is: HMDB03378
boundary condition: false
is: C00533

metaM strdnc e
is: SBO:0000247
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial concentration: 1.0
is: C16300
is: HMDB06547
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205608

metaR MALTSULtm
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000185
fast: false
name: Malate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_b3c65064_7ed5_4c3a_8889_c15fca3e8657
constant: false
name: NDUFB9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4715
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9Y6M9

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR HIStN1
product: MODEL1310110040#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
fast: false
name: Histidine transport (Na, H coupled)
kinetic law: MODEL1310110040#

metaM HC01403 x
constant: false
name: (S)-Hydroxydecanoyl-CoA
initial concentration: 1.0
is: CHEBI:28325
has only substance units: false
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM c101crn e
initial concentration: 1.0
constant: false
is: HMDB13205
boundary condition: false
name: decenoyl carnitine
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C17H31NO4 CHARGE: 0

metaM oxa e
is: HMDB02329
name: oxalate(2-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30623
boundary condition: false
type: Species

metaR SFGTH
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.2.12
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110040#
reversible: true
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: S-Formylglutathione hydralase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_cb841f3b_063a_4ee7_a6c4_47a661f839ba
is: SBO:0000252
has only substance units: false
name: _AA526438_1_m
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA526438
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a0776035_8065_46c2_932f_796b9959cc80
initial amount: NaN
is encoded by: hsa:79646
initial concentration: NaN
has only substance units: false
name: PANK3
type: Species
boundary condition: true
is: SBO:0000252
is: Q9H999
constant: false

metaM nadph c
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB00221
initial concentration: 1.0

metaM CE0849 m
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial concentration: 1.0
name: cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:57795
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaM vacc e
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
initial concentration: 1.0
is: CHEBI:30828
has only substance units: false
name: trans-vaccenate
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM no e
initial concentration: 1.0
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: CHEBI:16480
name: Nitric oxide
is: SBO:0000247
has only substance units: false
is: HMDB03378
boundary condition: false
is: C00533
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_e73b825f_ec31_4cc2_b006_e4da47b21dfe
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: P36957
name: DLST
is encoded by: hsa:1743
initial amount: NaN
is: SBO:0000252

metaR S6TASE15ly
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction

metaR r0604
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176

metaR FRDPtc
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110040#_670c1357_7fd0_4b99_87e4_4f4025dc5cdb
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PIGF
is: Q6IB04
boundary condition: true
initial amount: NaN
is encoded by: hsa:5281
constant: false

metaM strdnc c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
is: C16300
is: SBO:0000247
boundary condition: false
is: HMDB06547
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793

metaM m6mpdol L r
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37635
initial concentration: 1.0
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
has only substance units: false

metaR FUMSO3tm
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
reversible: true
name: Fumarate:sulfite antiport, mitochondrial
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110040#

metaM naglc2p L c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:18278
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
initial concentration: 1.0

metaR SIAT9g
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.9
kinetic law: MODEL1310110040#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
type: Reaction
reactant: MODEL1310110040#

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: L-aspartate(1-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:29991

metaM ppa c
name: propionate
type: Species
is: CHEBI:17272
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
is: HMDB00237
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_ebd7b8be_622f_4fc4_9bb2_1e4434e9c63f
constant: false
is: SBO:0000252
name: PIGV
has only substance units: false
is encoded by: hsa:55650
is: Q9NUD9
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r1167
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
name: EC:2.3.1.26

http://identifiers.org/biomodels.db/MODEL1310110040#_912cad69_c0f0_4bec_8f20_973e84e2ae07
is: SBO:0000252
is: Q6ZMR3
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:160287
name: LDHAL6A
boundary condition: true

metaM oxa c
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
boundary condition: false
initial concentration: 1.0
type: Species
name: oxalate(2-)
has only substance units: false
is: CHEBI:30623
initial amount: NaN
is: SBO:0000247
constant: false

metaR PRISTCOAtx
fast: false
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: true
name: pristcoa peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110040#_2db582f7_37dd_4a67_9ec9_21d0fd1882bf
is encoded by: hsa:6547
initial concentration: NaN
is: SBO:0000252
name: SLC8A3
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaM lnlccoa m
has only substance units: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial amount: NaN
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM CE2420 m
initial concentration: 1.0
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial amount: NaN
is: HMDB11123
constant: false
has only substance units: false
type: Species
is: CHEBI:28387
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

metaM hpdcacoa m
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB06497
name: heptadecanoyl coa

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
product: MODEL1310110040#
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is version of: http://identifiers.org/ec-code/2.3.1.12

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
is: SBO:0000247
name: L-2-aminoadipate(1-)
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:58672
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_51fc0007_95ee_40ea_b18d_0bdf4e9583d7
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: Q6PXP3
name: SLC2A7
has only substance units: false
type: Species
is encoded by: hsa:155184

http://identifiers.org/biomodels.db/MODEL1310110040#_b76738c4_0021_4941_b752_54d6faf91e38
is encoded by: hsa:4708
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: H7C5B8
name: NDUFB2

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM coa n
initial amount: NaN
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: coenzyme A(4-)
is: CHEBI:57287
initial concentration: 1.0

metaM xol7ah3 m
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB12455
is: CHEBI:28540
constant: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaM dmnoncoa x
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
name: 4,8 dimethylnonanoyl-CoA
constant: false
is: SBO:0000247
is: HMDB11604

metaR S6TASE14ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
type: Reaction
modifier: MODEL1310110040#

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM 3hodcoa c
constant: false
is: SBO:0000247
type: Species
name: (S)-3-Hydroxyoctadecanoyl-CoA
is: HMDB13336
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3ebfa213_c8d8_4fb7_84fc_859e84ea28e9
is: Q92604
initial concentration: NaN
type: Species
name: LPGAT1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:9926
constant: false

metaM na1 e
name: Sodium
type: Species
notes: FORMULA: Na CHARGE: 1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:4541
constant: false
is: HMDB00588
is: C01330
has only substance units: false

metaM ksi pre16 g
is: SBO:0000247
initial concentration: 1.0
is: C00130
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
constant: false
name: keratan sulfate I biosynthesis, precursor 16

metaM asp L e
is: CHEBI:29991
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00191
is: SBO:0000247
name: L-aspartate(1-)
type: Species
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055

http://identifiers.org/biomodels.db/MODEL1310110040#_89e8a92b_e60a_483d_9e6e_ba2700206f48
name: DCK
is encoded by: hsa:1633
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: P27707

metaR DCATDr
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the E.R. by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_9ff315ef_210e_4ea4_8ad7_4c0dec4dec98
is encoded by: hsa:3636
has only substance units: false
type: Species
boundary condition: true
is: O15357
name: INPPL1
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM crm hs r
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: N-acylsphingosine
type: Species
has only substance units: false
boundary condition: false

metaM hs deg5 l
name: heparan sulfate, degradation product 5
is: HMDB00158
type: Species
initial amount: NaN
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17895
is: SBO:0000247
initial concentration: 1.0

metaR XOLTRI25te
name: 25 trihydroxy cholesterol transport
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false

metaM glx m
initial concentration: 1.0
is: HMDB00119
boundary condition: false
type: Species
is: CHEBI:36655
is: SBO:0000247
constant: false
name: glyoxylate
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false

metaM 3octdeccrn e
initial amount: NaN
constant: false
boundary condition: false
name: 3-hydroxyoctadecanoyl carnitine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H49NO5 CHARGE: 0
is: HMDB13336
type: Species

metaM 7thf e
type: Species
constant: false
is: HMDB06559
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: heptaglutamyl folate (THF)
boundary condition: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
is: SBO:0000247

metaM xylt c
initial concentration: 1.0
is: HMDB02917
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: xylitol
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151

metaM coa m
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
type: Species
is: CHEBI:57287
is: SBO:0000247
is: C00010
constant: false
is: HMDB01423
boundary condition: false
name: Coenzyme A
initial amount: NaN
initial concentration: 1.0

metaM c6dc c
initial amount: NaN
name: adipoyl carnitine
has only substance units: false
type: Species
boundary condition: false
is: HMDB00705
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C13H22NO6 CHARGE: -1

metaR RE0958E
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
fast: false
name: RE0958
is: SBO:0000176
type: Reaction

metaR GALASE20ly
modifier: MODEL1310110040#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM stcoa c
constant: false
has only substance units: false
initial concentration: 1.0
name: Stearoyl-CoA (n-C18:0CoA)
boundary condition: false
is: SBO:0000247
type: Species
is: C00412
is: CHEBI:57394
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: HMDB01114
initial amount: NaN

metaR C3STDH1Pr
is described by: ECO:0000134
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reversible: false
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
type: Reaction

metaM CE2870 c
name: 3,3'-diiodo-L-thyronine 4'-O-sulfate
constant: false
notes: FORMULA: C15H12I2NO7S CHARGE: -1 INCHI: InChI=1/C15H13I2NO7S/c16-10-5-8(6-12(18)15(19)20)1-3-13(10)24-9-2-4-14(11(17)7-9)25-26(21,22)23/h1-5,7,12H,6,18H2,(H,19,20)(H,21,22,23)/p-1/t12-/m1/s1 EHMN_ABBREVIATION: CE2870
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15374
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02281

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_d3b658cb_71fd_4803_abd2_8a8dfca127c5
is: Q13613
is encoded by: hsa:8776
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: MTMR1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_dcfa582c_f93c_4f92_88f9_ef4f6d8f266c
name: PRDX3
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P30048
constant: false
is encoded by: hsa:10935
has only substance units: false

metaM lnlccrn c
has only substance units: false
is: HMDB06469
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110040#_070ed34c_e3c8_450c_9973_8279ce147d21
is: SBO:0000252
is encoded by: hsa:66035
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q8WXF9
name: SLC2A11

metaM q10 c
is: HMDB01072
is: CHEBI:46245
type: Species
initial amount: NaN
name: ubiquinone-10
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
is: SBO:0000247

metaM dgsn e
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB00085
initial amount: NaN
has only substance units: false
is: CHEBI:17172
is: SBO:0000247
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330

metaM coa l
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01423
is: SBO:0000247
boundary condition: false
name: coenzyme A(4-)
constant: false
initial concentration: 1.0
is: CHEBI:57287

metaM fuc L l
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: L-fucose
is: HMDB00174
is: CHEBI:18287
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_0f20ed72_41b3_4c33_a9b6_34b8adc2e7a7
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:514
type: Species
initial concentration: NaN
is encoded by: hsa:513
is: SBO:0000297
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM na1 c
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:4541
initial amount: NaN
has only substance units: false
constant: false
name: Sodium
is: C01330

http://identifiers.org/biomodels.db/MODEL1310110040#_cd6fdfd4_e18c_425d_8e15_bb7222a40586
initial amount: NaN
initial concentration: NaN
name: _AF080579_1_c
constant: false
type: Species
has only substance units: false
is encoded by: hsa:AF080579
is: SBO:0000252
boundary condition: true

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR LDH L
fast: false
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110040#
name: L-lactate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110040#_37ea0267_e989_4713_91b6_000c49e7b351
constant: false
name: PIGC
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:5279
is: Q92535

metaR r0641
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM strdnccrn c
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
is: HMDB06463
has only substance units: false
constant: false
name: stearidonyl carnitine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM asp L c
is: CHEBI:29991
initial concentration: 1.0
constant: false
name: L-aspartate(1-)
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d486c1a5_3dd7_44a3_8ba7_89a071141347
boundary condition: true
name: COX5B
is encoded by: hsa:1329
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q53YB7

metaR FERO
reactant: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
name: ferroxidase
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is described by: ECO:0000134
product: MODEL1310110040#

metaR ALAGLYexR
product: MODEL1310110040#
fast: false
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
name: L-alanine/glycine reversible exchange

metaM c6dc e
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB00705
name: adipoyl carnitine
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM 56dthm m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27468
constant: false
is: HMDB00079
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 5,6-dihydrothymine
type: Species
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906

metaR r0642
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3

metaM cholp g
has only substance units: false
name: choline phosphate(1-)
is: CHEBI:295975
boundary condition: false
constant: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00588

http://identifiers.org/biomodels.db/MODEL1310110040#_e9127bf1_8911_450d_bfa8_372b23f2ec4a
boundary condition: true
is: B3KUK6
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:93034
name: NT5C1B
type: Species

metaR CSNAT3x
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
name: carnitine O-aceyltransferase, peroxisomal
reactant: MODEL1310110040#

metaR r1444
is: SBO:0000176
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
name: EC:1.3.3.6
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#

metaM 3tetd7ecoacrn e
is: HMDB02014
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H39NO5 CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 3-hydroxy tetradecenoyl-7-carnitine

metaM dgsn c
is: SBO:0000247
name: Deoxyguanosine
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:17172
type: Species
is: HMDB00085
has only substance units: false
is: C00330

http://identifiers.org/biomodels.db/MODEL1310110040#_11c457b0_cd0b_4d8e_95e5_b6bbc5338f58
has part: O95497
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
has only substance units: false
is: SBO:0000297
is encoded by: hsa:8876
initial concentration: NaN
type: Species
has part: A8K7W0
is encoded by: hsa:55350
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_d329634e_a483_4600_a82b_35d980087560
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q16775
type: Species
name: HAGH
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3029

metaR NACHEX11ly
kinetic law: MODEL1310110040#
reversible: false
type: Reaction
modifier: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110040#
is described by: ECO:0000000

metaR PCHOLPm hs
reversible: false
is described by: ECO:0000269
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
name: choline phosphatase
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
type: Species

metaM q10 e
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: ubiquinone-10
is: CHEBI:46245
is: HMDB01072

metaR NACHEX26ly
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_f47ec004_740a_4cef_a506_eb33d1c26bb3
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4731
constant: false
name: NDUFV3
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_18e3ff2f_738a_4e1b_9deb_ea7b1e0a551b
is encoded by: hsa:54963
initial amount: NaN
is: Q53HM1
initial concentration: NaN
is: SBO:0000252
name: UCKL1
has only substance units: false
type: Species
constant: false
boundary condition: true

metaR r1443
kinetic law: MODEL1310110040#
fast: false
name: EC:1.3.3.6
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
product: MODEL1310110040#
is: SBO:0000176

metaM crm hs l
name: N-acylsphingosine
initial amount: NaN
is: CHEBI:52639
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
is: SBO:0000247

metaM man l
is: HMDB00169
name: D-mannose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16024
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_bc2f395b_e14c_44ff_88bf_e51d1e1145d7
is encoded by: hsa:2571
constant: false
is: Q99259
has only substance units: false
name: GAD1
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_5b284b7d_72e9_4937_9fcc_7a9d39f11a45
initial amount: NaN
constant: false
is encoded by: hsa:8801
has part: Q96I99
boundary condition: true
type: Species
is: SBO:0000297
name: SUCLG2:SUCLG1
is encoded by: hsa:8802
has only substance units: false
has part: P53597
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_f0fc7f30_fc61_4300_906e_bd93f319c0e4
is encoded by: hsa:9517
is: SBO:0000297
type: Species
has part: O15269
name: SPTLC1:SPTLC2
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10558
has part: O15270

metaR STRDNCCRNt
is described by: ECO:0000000
product: MODEL1310110040#
type: Reaction
name: transport into the mitochondria (carnitine)
is: SBO:0000185
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_f15abbec_e497_4c69_b3cb_8f0821036a48
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5141
name: PDE4A
is: P27815
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaM idour l
name: L-iduronate
initial concentration: 1.0
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
type: Species
is: HMDB02704
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM coa r
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
constant: false
boundary condition: false
is: SBO:0000247
name: Coenzyme A
is: CHEBI:57287
has only substance units: false
is: HMDB01423
type: Species
initial amount: NaN
initial concentration: 1.0

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r1446
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110040#
name: EC:1.3.3.6
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#

metaR ST8SIA51g
is described by: ECO:0000269
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_d289b107_6971_44b6_af71_f57ab6f4039f
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5297
is: SBO:0000252
boundary condition: true
constant: false
is: B4DYG5
initial amount: NaN
name: PI4KA

metaR NRPPHRt4 2 r
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: Norepinephrine reversible transport in via sodium symport (1:2)
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110040#

metaM 3tetd7ecoacrn c
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-carnitine
constant: false
type: Species
notes: FORMULA: C21H39NO5 CHARGE: 0
initial concentration: 1.0
is: HMDB02014
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR DOLPMT1 Ler
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reversible: false
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000

metaM nadh m
has only substance units: false
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
is: C00004
is: HMDB01487
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM ins e
name: Inosine
boundary condition: false
is: CHEBI:17596
initial concentration: 1.0
type: Species
is: C00294
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: HMDB00195

http://identifiers.org/biomodels.db/MODEL1310110040#_cfc01bc8_b3c6_45f5_9e2e_b4c3db57bcb8
constant: false
is encoded by: hsa:47
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: ACLY

metaR 3SALATAim
reactant: MODEL1310110040#
type: Reaction
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain

metaR FAOXC183803m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:3, n-3 -> c8:0 - 5 rounds of beta ox, lose 3 degrees of unsat - only 2 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaM glyc m
is: C00116
is: SBO:0000247
boundary condition: false
name: Glycerol
is: HMDB00131
has only substance units: false
type: Species
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_ee79ff9d_33fd_4f20_aff0_2c23d804c43b
type: Species
name: PPT1
constant: false
initial amount: NaN
is: Q6FGQ4
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5538
is: SBO:0000252

metaR XOLTRI25tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110040#
name: 25 trihydroxy cholesterol transport
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185
reversible: true

metaR r1445
reversible: false
product: MODEL1310110040#
is described by: ECO:0000000
name: EC:1.3.3.6
fast: false
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110040#

metaR DM T antigen g
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaM xylt e
is: CHEBI:17151
is: HMDB02917
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: xylitol
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaM pristcoa c
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:51341
is: SBO:0000247

metaR RE0830N
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
reversible: true
fast: false
name: RE0830
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96

metaM bilglcur c
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
is: CHEBI:57767
has only substance units: false
initial concentration: 1.0
constant: false

metaR HAtly
kinetic law: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110040#
name: hyaluronan transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false

metaR DDCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR EX pydx LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b0f0168a_271a_4133_adc1_17682ea2e008
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:H17063
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _H17063_1_c

metaR r1593
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110040#

metaR FAOXTC162TC142m
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_c4d279ae_8e48_4321_be91_b41b96d24eaa
initial amount: NaN
type: Species
is: Q15181
initial concentration: NaN
is: SBO:0000252
constant: false
name: PPA1
boundary condition: true
is encoded by: hsa:5464
has only substance units: false

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110040#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
modifier: MODEL1310110040#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
reversible: false

metaM nadph r
is: CHEBI:57783
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00005
type: Species
has only substance units: false

metaM em2emgacpail hs r
constant: false
type: Species
boundary condition: false
has only substance units: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
initial concentration: 1.0
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
is: SBO:0000247
initial amount: NaN

metaM HC01115 c
name: NeuNGc
initial concentration: 1.0
is: CHEBI:29025
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e9867b7c_c9ee_4493_8525_3e0f806b4936
is encoded by: hsa:5092
boundary condition: true
type: Species
is: P61457
name: PCBD1
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR RE1796M
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
name: RE1796
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000

metaM sbt D c
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17924
name: D-glucitol
type: Species
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial amount: NaN
initial concentration: 1.0
is: HMDB00247

http://identifiers.org/biomodels.db/MODEL1310110040#_99a6ed48_867d_4bdb_ba6d_d8ef18e67236
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _FLJ44968_1_m
constant: false
is encoded by: hsa:FLJ44968
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_20370296_95ee_4052_95bf_a50cca66948c
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: P15954
is encoded by: hsa:1350
name: COX7C

metaR LNLCCRNt
product: MODEL1310110040#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false

metaM ins c
is: SBO:0000247
name: Inosine
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: C00294
has only substance units: false
is: CHEBI:17596
is: HMDB00195
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

metaR GLUTCOAACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaM glysar e
type: Species
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/93131
name: Glycylsarcosine

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
has only substance units: false
is: CHEBI:30794
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
name: Malonate

metaM lnlccrn m
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06469
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
name: Linoleyl carnitine
type: Species

metaR r1592
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#

metaM HC01407 m
is: CHEBI:28276
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_f7648976_ff7c_4f00_9b2b_4e1ab10cca00
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: MYO5B
is: Q9H6Y6
is encoded by: hsa:4645
initial concentration: NaN

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR MCLACCYSR
name: 3-mercaptolactate:cysteine reductase
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is: SBO:0000176

metaR RE3524R
name: RE3524
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is: SBO:0000176

metaM didp c
constant: false
is: CHEBI:28823
is: HMDB03536
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: dIDP
is: SBO:0000247

metaM ipdp x
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
is: HMDB01347
name: isopentenyl diphosphate(3-)
is: CHEBI:128769
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM man g
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16024
is: HMDB00169
name: D-mannose

http://identifiers.org/biomodels.db/MODEL1310110040#_1b3f694e_5eb2_4518_a0f1_6476414b8f98
constant: false
name: SLC1A7
boundary condition: true
is encoded by: hsa:6512
initial concentration: NaN
is: O00341
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_32c631c2_5c9f_474c_a957_365b4b087631
is: O15245
initial amount: NaN
name: SLC22A1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6580
constant: false
boundary condition: true

metaM dcamp c
constant: false
is: SBO:0000247
is: HMDB00536
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: CHEBI:57567
initial amount: NaN
is: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP

metaM pydx5p c
is: C00018
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: CHEBI:597326
name: Pyridoxal 5'-phosphate
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01491

http://identifiers.org/biomodels.db/MODEL1310110040#_b1005e06_ad55_49a2_9e04_833148fe4fc6
initial concentration: NaN
has only substance units: false
is: Q9H936
is encoded by: hsa:79751
is: SBO:0000252
name: SLC25A22
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR PLA2 2e
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
name: phospholipase A2
is version of: http://identifiers.org/ec-code/3.1.1.4
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#

metaR LDH D
product: MODEL1310110040#
modifier: MODEL1310110040#
name: D-lactate dehydrogenase
fast: false
is version of: http://identifiers.org/ec-code/1.1.2.4
reversible: true
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000304

metaR RE1804M
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
name: RE1804
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110040#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM sbt D e
constant: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00247
boundary condition: false
is: SBO:0000247
name: D-glucitol
initial concentration: 1.0

metaM galgluside hs g
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
boundary condition: false
name: galactosyl glucosyl ceramide
constant: false
is: CHEBI:58223
is: SBO:0000247
is: C00015
is: HMDB00295

metaM fuc L c
name: L-fucose
has only substance units: false
boundary condition: false
is: HMDB00174
initial amount: NaN
is: CHEBI:18287
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2397ef17_b14f_41ef_a765_7a2cac5f6a9b
has only substance units: false
is: P00558
is: SBO:0000252
constant: false
name: PGK1
is encoded by: hsa:5230
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaR r1595
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR PSYTCHe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM 56dthm c
initial concentration: 1.0
has only substance units: false
name: 5,6-dihydrothymine
constant: false
is: HMDB00079
initial amount: NaN
type: Species
is: CHEBI:27468
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
boundary condition: false

metaM idour c
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB02704
name: L-iduronate
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
initial amount: NaN
is: CHEBI:21338
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_979ef2ae_2de3_4014_86ae_429e2e9a1826
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: P30837
is: SBO:0000252
is encoded by: hsa:219
name: ALDH1B1
initial amount: NaN
constant: false

metaR GLCAASE9ly
product: MODEL1310110040#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
name: beta-glucuronidase, lysosomal
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#

metaR NAGLCAly
fast: false
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
name: N-acetylglucosaminidase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#

metaR r1734
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_047159a4_74aa_4f7b_b899_3c6105595cb1
is encoded by: hsa:7083
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: TK1
is: P04183
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_90cc5350_5c6a_4fad_9496_4e50b0662ef7
constant: false
is: Q9NRZ5
is encoded by: hsa:56895
boundary condition: true
name: AGPAT4
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_69c3d5f8_c389_4654_a812_e574f9649b81
name: ST3GAL1
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6482

http://identifiers.org/biomodels.db/MODEL1310110040#_9a84e1e1_051d_47bc_8c97_06cf93ab84b6
name: FH
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: P07954
initial concentration: NaN
constant: false
is encoded by: hsa:2271
initial amount: NaN

metaR HDCAtr
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_27ea2a12_a76d_4c29_b07d_78c0dd0532e8
is: P43155
type: Species
name: CRAT
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1384
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_42f27f16_8193_40d2_bccb_dfee94e36d2a
is encoded by: hsa:AI480132
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI480132_1_c
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaM thyox L e
is: HMDB00248
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
has only substance units: false
type: Species
constant: false
is: CHEBI:18332
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR MG1er
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110040#_cd9d282b_7c4d_43f4_b2c7_cfd84ec4da68
is encoded by: hsa:93034
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: NT5C1B
initial concentration: NaN
is: Q96P26
initial amount: NaN

metaR C12OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM nadh r
initial concentration: 1.0
constant: false
is: CHEBI:57945
has only substance units: false
is: HMDB01487
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: NADH(2-)

metaM fuc L e
has only substance units: false
type: Species
name: L-fucose
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial concentration: 1.0
is: CHEBI:18287
constant: false
is: SBO:0000247
is: HMDB00174
boundary condition: false

metaM coa c
type: Species
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial concentration: 1.0
name: Coenzyme A
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:3312
is: C00010
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_bb647137_fa9e_4873_a2d9_8c30c32dcdb8
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:56623
initial concentration: NaN
is: Q9NRR6
is: SBO:0000252
name: INPP5E

metaR r1594
reactant: MODEL1310110040#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR CREATt4 2 r
type: Reaction
fast: false
is: SBO:0000185
name: Creatine transport (sodium symport) (2:1)
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM glx c
is: CHEBI:36655
has only substance units: false
is: SBO:0000247
name: glyoxylate
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
boundary condition: false
constant: false

metaR CYOR u10m
fast: false
name: ubiquinol-6 cytochrome c reductase, Complex III
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH

metaR ASPTA
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
type: Reaction
name: aspartate transaminase
is: SBO:0000176
modifier: MODEL1310110040#
reversible: true
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:

metaR r2140
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM 3oddcoa m
constant: false
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false
initial concentration: 1.0
is: HMDB03937
name: 3-Oxododecanoyl-CoA
is: CHEBI:27868
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_24ab9187_9312_4066_a2e3_82208e39b37f
boundary condition: true
is: Q99714
is encoded by: hsa:3028
name: HSD17B10
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a481ca72_4adc_4d2f_94f9_b86ea0ca0bfd
boundary condition: true
is encoded by: hsa:518
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: ATP5G3
initial concentration: NaN
is: SBO:0000252

metaR PPNCL3
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
product: MODEL1310110040#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphopantothenate-cysteine ligase
is described by: ECO:0000269
modifier: MODEL1310110040#

metaR r0752
is described by: ECO:0000000
type: Reaction
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110040#

metaR RE0830C
fast: false
name: RE0830
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_337f43c9_dc9b_4f06_b1ba_c7b46a05b432
initial amount: NaN
is: P48728
is encoded by: hsa:275
type: Species
constant: false
initial concentration: NaN
name: AMT
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b8f6ac69_40ad_4dda_8227_f59b0ad014eb
has only substance units: false
name: PDE2A
initial concentration: NaN
is encoded by: hsa:5138
constant: false
is: Q8IW54
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR RE3245C
type: Reaction
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
is described by: ECO:0000000
product: MODEL1310110040#
reversible: true
is: SBO:0000176
name: RE3245
kinetic law: MODEL1310110040#

metaM idour e
name: L-iduronate
is: CHEBI:21338
constant: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB02704

http://identifiers.org/biomodels.db/MODEL1310110040#_72d01c7c_7a3a_4ee1_b2ab_0ede07a4aaec
has only substance units: false
initial amount: NaN
name: SLC6A10P
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:386757
constant: false
type: Species

metaR EX psyltchol LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-taurocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b11e3be1_6f41_4e18_906d_d60744fd5811
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM hretn n
type: Species
initial amount: NaN
boundary condition: false
name: 4 hydroxy retinoic acid
is: HMDB06254
constant: false
initial concentration: 1.0
notes: FORMULA: C20H27O3 CHARGE: -1
is: SBO:0000247
has only substance units: false

metaM na1 r
is: CHEBI:29101
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00588
name: sodium(1+)
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_f85d6590_bbd9_44c9_a128_c6d391ca5c8f
constant: false
is encoded by: hsa:48
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P21399
boundary condition: true
name: ACO1
type: Species
is: SBO:0000252

metaR AG13T9g
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#

metaM man c
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
name: D-Mannose
initial concentration: 1.0
is: CHEBI:16024
is: C00159
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00169
constant: false

metaR r2141
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110040#

metaM nadh x
boundary condition: false
is: C00004
type: Species
is: CHEBI:57945
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
constant: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
has only substance units: false

metaR r0753
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_c25aeb48_5587_46f2_9582_73f7e946e094
initial concentration: NaN
name: _PRO1933_1_m
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:PRO1933
is: SBO:0000252
has only substance units: false

metaM glac c
initial amount: NaN
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
constant: false
is: HMDB06355
name: D-glucurono-6,3-lactone
boundary condition: false
type: Species
is: CHEBI:18268
is: SBO:0000247
has only substance units: false

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR ME1m
modifier: MODEL1310110040#
reversible: false
product: MODEL1310110040#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
name: malic enzyme (NAD), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110040#_f624bc1d_082d_4ada_a88a_69af636ea5b8
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:728441
name: GGT2
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_ea134bca_14ca_4416_9e55_ef0971a1cf8e
type: Species
is: B4DX62
initial amount: NaN
name: ST3GAL3
is encoded by: hsa:6487
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR GALGT1
is version of: http://identifiers.org/ec-code/2.4.1.92
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877,PMID:8702839 NOTES:NJ
product: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110040#
fast: false
type: Reaction
name: Beta-1,4 N-acetylgalactosaminyltransferase
reversible: false

metaR URIt
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: uridine facilated transport in cytosol
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
type: Reaction

metaR r0750
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176

metaR r2142
reactant: MODEL1310110040#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: true
product: MODEL1310110040#
is: SBO:0000185
fast: false
type: Reaction

metaR r1591
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
fast: false
reversible: true
product: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR Ser Thrtg
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000269
name: Ser/Thr transport (from golgi to lysosome)
type: Reaction

metaR EX 3hexdcrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaM 4mop m
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: SBO:0000247
type: Species
initial amount: NaN
name: 4-methyl-2-oxopentanoate
is: HMDB00695
is: CHEBI:17865
has only substance units: false
constant: false
initial concentration: 1.0

metaM glysar c
boundary condition: false
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
type: Species
name: Glycylsarcosine
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM decdicoa c
type: Species
name: decadienoylcoa
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01168
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e680bf8f_e259_4f66_8534_eea95db0b6cf
name: NME6
has only substance units: false
initial amount: NaN
type: Species
is: O75414
boundary condition: true
is encoded by: hsa:10201
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b648ebdb_adcc_4c26_9b30_a29c9e78313d
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: Q969I6
constant: false
is encoded by: hsa:55089
name: SLC38A4
has only substance units: false

metaR r0360
kinetic law: MODEL1310110040#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.16

metaM ksii core2 pre8 g
initial amount: NaN
is: HMDB00175
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
has only substance units: false
constant: false
is: C00130
boundary condition: false

metaM trdrd c
initial amount: NaN
boundary condition: false
is: C00342
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
constant: false
name: Reduced thioredoxin
initial concentration: 1.0
has only substance units: false
is: CHEBI:15967
is: SBO:0000247

metaM ncam c
notes: FORMULA: C6H6N2O CHARGE: 0
is: HMDB01406
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
name: Nicotinamide
is: C00153
is: CHEBI:0
has only substance units: false
initial concentration: 1.0
constant: false

metaR C4tcx
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM lac D c
is: HMDB01311
constant: false
name: (R)-lactate
initial concentration: 1.0
type: Species
is: CHEBI:16004
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN

metaM man e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
name: D-Mannose
is: CHEBI:16024
initial concentration: 1.0
is: C00159
initial amount: NaN
is: HMDB00169
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM stcoa m
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01114
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412
is: CHEBI:57394
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412

http://identifiers.org/biomodels.db/MODEL1310110040#_e4fc1bc9_9849_4cdb_becc_88a31b6045d5
initial amount: NaN
name: PLA2G2D
initial concentration: NaN
is: Q9UNK4
has only substance units: false
is encoded by: hsa:26279
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR r1590
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE4876 r
is: CHEBI:15748
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial concentration: 1.0
name: delta12-Prostaglandin J2
type: Species
is: HMDB00127
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaM nadph m
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
type: Species
is: CHEBI:57783
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00221
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: C00005

http://identifiers.org/biomodels.db/MODEL1310110040#_9d6b2666_b084_4aad_8a37_637520a0853d
name: ACADL
boundary condition: true
has only substance units: false
is encoded by: hsa:33
is: SBO:0000252
is: P28330
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaM pydx5p e
boundary condition: false
is: CHEBI:597326
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01491
name: pyridoxal 5'-phosphate(2-)
is: SBO:0000247
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018

metaM 3octdeccrn c
type: Species
constant: false
name: 3-hydroxyoctadecanoyl carnitine
notes: FORMULA: C25H49NO5 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB13336
has only substance units: false

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_79cbb7ed_96c9_4202_94eb_cbcb03ff41c0
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: ALG3
boundary condition: true
is encoded by: hsa:10195
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_eca813fb_b49e_4947_aeb9_5d4321b7cb36
constant: false
is: SBO:0000252
name: _LOC647190_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:LOC647190
boundary condition: true
type: Species

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR DCSPTN1t
name: fatty acid transport via diffusion
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110040#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction

metaM octd11ecoa c
name: 11-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: C08277
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00792
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7d4caab9_9d0a_4bb7_b13f_51f326ce5a31
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: MYO5B
is encoded by: hsa:4645
initial amount: NaN
is: Q9H6Y6
has only substance units: false

metaM HC01434 m
type: Species
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
initial amount: NaN
is: CHEBI:58931
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

metaM ps hs c
has only substance units: false
is: CHEBI:18303
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
constant: false
is: SBO:0000247
name: ps_hs[c]
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_474b3443_3b8a_4dcc_9fab_7d446bbc2ac5
boundary condition: true
is: O00746
name: NME4
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4833
constant: false

metaM 25aics c
is: HMDB00797
is: SBO:0000247
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
has only substance units: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: CHEBI:58443
is: C04823
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a956f748_f0ca_4b20_adbf_61fa7939e268
name: SLC25A1
is encoded by: hsa:6576
boundary condition: true
is: D9HTE9
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM ksi deg34 l
initial amount: NaN
name: keratan sulfate I, degradation product 34
is: HMDB01354
is: CHEBI:57455
has only substance units: false
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR DCATDc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Decanoate (n-C10:0) into the cell by diffusion
type: Reaction

metaM tcynt c
initial concentration: 1.0
type: Species
constant: false
name: thiocyanate
is: SBO:0000247
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01453

metaM ncam e
has only substance units: false
initial concentration: 1.0
is: HMDB01406
constant: false
notes: FORMULA: C6H6N2O CHARGE: 0
is: CHEBI:0
type: Species
initial amount: NaN
is: C00153
name: Nicotinamide
is: SBO:0000247
boundary condition: false

metaR PROSTGE2t
is: SBO:0000185
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: prostaglandin transport via bicarbonate countertransport
type: Reaction

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR EX 3octdece1crn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR DM ethamp r
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR RE0926E
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110040#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: RE0926
is: SBO:0000176

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR GALGT4
is described by: ECO:0000269
product: MODEL1310110040#
name: Beta-1,4 N-acetylgalactosaminyltransferase
kinetic law: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.92
modifier: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_8c70ba28_0782_4f5f_8f5f_3909b422167e
has only substance units: false
name: PRDX2
initial concentration: NaN
is encoded by: hsa:7001
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_f7b6ab86_8c6a_44c4_9f67_7d423f5f6406
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR r0055
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is version of: http://identifiers.org/ec-code/2.4.2.8
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is version of: http://identifiers.org/ec-code/2.4.2.7
reversible: true
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000

metaM h2o2 e
is: CHEBI:16240
initial concentration: 1.0
initial amount: NaN
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
type: Species
has only substance units: false
constant: false
name: hydrogen peroxide
is: SBO:0000247

metaR r0744
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
fast: false

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR q10tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110040#
type: Reaction
fast: false
name: transport of ubiquinone into mitochondria
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185

metaR NTD7
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
modifier: MODEL1310110040#
name: 5'-nucleotidase (AMP)
reversible: false
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_58684fbe_27c8_44d1_9dcd_3ba0c0dfb450
name: LDHC
initial concentration: NaN
constant: false
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

metaM ps hs e
has only substance units: false
is: CHEBI:18303
initial amount: NaN
name: phosphatidylserine
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_8c4c892a_e4f6_4144_b6ed_b97051a4149f
type: Species
is: Q3KQV9
is encoded by: hsa:91373
initial concentration: NaN
name: UAP1L1
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR GALGT3
reactant: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
name: Beta-1,4 N-acetylgalactosaminyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.92
product: MODEL1310110040#

metaR CYTK5n
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
fast: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

metaR GLCNACPT L
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (liver)
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.15
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000

metaM hxan c
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
is: CHEBI:17368
initial concentration: 1.0
boundary condition: false
name: Hypoxanthine
is: SBO:0000247
is: C00262
constant: false
type: Species
is: HMDB00157
initial amount: NaN

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM tcynt e
boundary condition: false
constant: false
name: thiocyanate
is: CHEBI:18022
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01453
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_e5f563f9_565e_4386_8b5b_52ac96f21606
type: Species
name: DUOX2
is: Q9NRD8
constant: false
is encoded by: hsa:50506
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR NACHEX1ly
kinetic law: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal

metaM gdp n
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58189
name: GDP(3-)
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaM 3hpp m
boundary condition: false
initial concentration: 1.0
is: HMDB00700
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
is: CHEBI:16510
type: Species
is: SBO:0000247
name: 3-hydroxypropionate
initial amount: NaN
constant: false

metaR ASNtN1
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
modifier: MODEL1310110040#

metaM hs deg19 l
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
type: Species
constant: false
boundary condition: false
name: heparan sulfate, degradation product 19
is: HMDB06254
has only substance units: false

metaM pristcoa x
is: SBO:0000247
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
is: CHEBI:51341
constant: false
name: pristanoyl coa
has only substance units: false
initial concentration: 1.0
type: Species

metaR r2393
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r0365
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000000
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
kinetic law: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false

metaM HC00319 c
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
name: Malonate
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR r0743
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reversible: false
modifier: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_37a53f52_c516_4119_8c11_d9e038a5fb00
has only substance units: false
name: GMPPA
initial amount: NaN
is encoded by: hsa:29926
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM glac r
type: Species
boundary condition: false
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: D-glucurono-6,3-lactone
is: CHEBI:18268
is: SBO:0000247

metaM gly m
constant: false
name: Glycine
has only substance units: false
type: Species
is: C00037
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: HMDB00123
is: SBO:0000247
boundary condition: false

metaR GALGT2
type: Reaction
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.92
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: Beta-1,4 N-acetylgalactosaminyltransferase
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false

metaM crm hs c
is: CHEBI:52639
initial amount: NaN
name: N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ae243062_40b6_4c9b_9008_5c09ccdb371b
boundary condition: true
initial amount: NaN
constant: false
is: B1AM93
is encoded by: hsa:4702
type: Species
name: NDUFA8
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM gdp m
constant: false
type: Species
name: GDP
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00035

metaM h2o2 c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
initial amount: NaN
is: HMDB03125
is: C00027
has only substance units: false
type: Species
name: Hydrogen peroxide
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_87dfb7a5_3458_4482_b4c5_ca57dd9e4b59
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56913
is: Q9NS00
name: C1GALT1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR EX 3ivcrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR r1596
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM homoval m
has only substance units: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:545959
constant: false
boundary condition: false
name: Homovanillate
is: HMDB00118

metaM hdd2coa m
is: HMDB03945
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
constant: false
initial amount: NaN
is: C05272
name: trans-Hexadec-2-enoyl-CoA
is: CHEBI:61526
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_acb0d778_1281_40e2_afdb_18ca6fb26579
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NSDHL
is: Q15738
is encoded by: hsa:50814
initial amount: NaN
initial concentration: NaN

metaR G14T16g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110040#
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR F6Tg
product: MODEL1310110040#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
name: glycoprotein 6-alpha-L-fucosyltransferase

metaM c6dc x
type: Species
initial amount: NaN
is: HMDB04047
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C14143
has only substance units: false
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1
name: adipoyl carnitine

metaM HC10852 r
name: palmitoleyl-CoA(4-)
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
is: CHEBI:61540
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species

metaR CHAT
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
name: Choline O-acetyltransferase
modifier: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_0ad69ef3_db66_4ca7_8ce4_630429e5144a
has only substance units: false
is encoded by: hsa:4704
is: Q16795
name: NDUFA9
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaR r1150
type: Reaction
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110040#
name: Facilitated diffusion
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_6f5ab78d_0e5b_4a2c_85d2_cadfb9b82756
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:55967
is: F8VQS7
boundary condition: true
has only substance units: false
is: SBO:0000252
name: NDUFA12

http://identifiers.org/biomodels.db/MODEL1310110040#_fffb273d_4bcd_46d5_97e4_37edc03b2901
is: A0S0A7
is encoded by: hsa:4846
initial concentration: NaN
name: NOS3
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM thyox L c
is: HMDB00248
name: L-thyroxine
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:18332
initial concentration: 1.0
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ec9e9d35_d8a6_47f7_8a5a_21dabb1441b9
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:171425
name: CLYBL
boundary condition: true
is: SBO:0000252
constant: false
is: Q8N0X4
type: Species

metaR NDPK9n
reversible: true
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269

metaR r1597
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR r2526
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM c226crn c
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/127055
name: cervonyl carnitine
type: Species
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB06510

metaM 4mop c
boundary condition: false
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
is: HMDB00695
constant: false
initial amount: NaN

metaR FAS100COA
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
name: fatty acyl-CoA synthase (n-C10:0CoA)

metaM gdp g
type: Species
is: HMDB01201
initial concentration: 1.0
initial amount: NaN
name: GDP(3-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
constant: false
is: CHEBI:58189

metaM hdcecrn c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: Hexadecenoyl carnitine
constant: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
boundary condition: false
is: HMDB00222

metaR r0051
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
kinetic law: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5

metaM strdnccrn m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
type: Species
constant: false
name: stearidonyl carnitine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06463

http://identifiers.org/biomodels.db/MODEL1310110040#_5ea754d3_e020_4e21_9f74_6c8243cebef6
name: _NOS2A_1_e
initial concentration: NaN
is encoded by: hsa:NOS2A
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_7f7884bf_c588_4b97_9ad9_0bdc449fac79
initial amount: NaN
is encoded by: hsa:51166
boundary condition: true
initial concentration: NaN
constant: false
is: Q4W5N8
has only substance units: false
is: SBO:0000252
name: AADAT
type: Species

metaR HEDCECRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR r1598
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR HDCAter
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
name: palmitate ER export

http://identifiers.org/biomodels.db/MODEL1310110040#_a95e4621_d0be_4a3c_b1d6_95d33d7b5c80
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27165
name: GLS2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_f3ff6c7c_e5fb_4470_bcde_d0a0eb561903
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:79053
name: ALG8
type: Species

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_3cbd82d7_a471_4319_8294_51f330d3ba84
constant: false
initial concentration: NaN
is: P35270
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: SPR
is encoded by: hsa:6697

http://identifiers.org/biomodels.db/MODEL1310110040#_ccf5e4ad_5ebf_40d3_9281_1b2b42d8cc46
is: O00483
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
name: NDUFA4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4697

http://identifiers.org/biomodels.db/MODEL1310110040#_a5976baa_dab8_4118_83d2_8c31bb0ccfdc
name: CTPS1
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: P17812
is encoded by: hsa:1503
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r0747
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110040#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is described by: ECO:0000000

metaR r1599
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM trdrd m
is: CHEBI:15967
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Reduced thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110040#_1bf3d144_6550_4c94_9d79_5386b86f2b6d
constant: false
name: CDIPT
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10423
initial concentration: NaN
type: Species
boundary condition: true
is: A8K3L7
has only substance units: false

metaM 4mop e
constant: false
has only substance units: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00695
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1

metaM sbcoa x
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB02014
name: suberylcoa
has only substance units: false
constant: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
type: Species
initial concentration: 1.0

metaM CE5160 r
initial concentration: 1.0
type: Species
is: HMDB00127
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15748
name: 3-oxo-cis-9-octadecenoyl-CoA
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160

metaM gq1b hs g
is: SBO:0000247
type: Species
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
boundary condition: false
initial amount: NaN
constant: false
is: C00249
is: HMDB00220
initial concentration: 1.0
is: CHEBI:7896
name: GQ1b
has only substance units: false

metaR LSTO1r
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.21.6
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is described by: ECO:0000269
name: Lathosterol oxidase

metaM m5masnC g
is: HMDB02985
constant: false
type: Species
initial amount: NaN
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
is: CHEBI:58433
is: SBO:0000247
notes: FORMULA: C52H87N2O40X CHARGE: 0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b0d0bb5a_2a08_42dc_862c_e2d36700b096
name: SLC6A12
initial concentration: NaN
is: P48065
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6539

metaR S6T5g
is: SBO:0000176
modifier: MODEL1310110040#
fast: false
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110040#

metaM ksi deg4 l
initial concentration: 1.0
is: HMDB00868
is: CHEBI:57737
name: keratan sulfate I, degradation product 4
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
has only substance units: false

metaM nadh c
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
initial concentration: 1.0
is: C00004
is: CHEBI:57945
boundary condition: false
type: Species
is: HMDB01487
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
constant: false

metaR ACACT7p
reactant: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110040#_67a8cd3c_f0b5_4027_b395_c4340fc384e9
type: Species
is encoded by: hsa:BE966236
name: _BE966236_1_m
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR GCCbim
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110040#
type: Reaction
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
modifier: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_dd06ea3b_7e14_4a82_8749_190b561613dc
constant: false
name: CLC
is encoded by: hsa:1178
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: C5HZ13

metaM hretn c
initial amount: NaN
notes: FORMULA: C20H27O3 CHARGE: -1
name: 4 hydroxy retinoic acid
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06254
constant: false
initial concentration: 1.0
has only substance units: false

metaM ksii core2 pre5 g
name: keratan sulfate II biosynthesis, precursor 5
initial concentration: 1.0
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: C00130
is: HMDB00175
type: Species

metaR r1154
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
name: EC:1.2.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110040#
reversible: true

metaR SPHINGStl
is described by: ECO:0000000
reversible: true
name: sphingosine intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaR NDPK5n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true

metaR r0639
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
fast: false
type: Reaction
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000

metaM prostgi2 c
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
name: prostaglandin I2(1-)
is: CHEBI:57403
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01335

metaR DCSPTN1CRNt
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
fast: false
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#

metaR r0475
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110040#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#

metaM gly x
initial amount: NaN
name: glycine
is: CHEBI:15428
is: SBO:0000247
type: Species
is: HMDB00123
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3bf286f0_7d55_4933_8629_cc29b95f1dc4
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: GUCY1A2
is: P33402
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2977

metaR RE1525M
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110040#
name: RE1525
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_a75cd177_65da_472a_830b_d9ef3867a867
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ATP5G2
is encoded by: hsa:517

metaR EX c81crn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaM psylchol e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0
name: psillium-glycocholic acid complex
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM pmtcrn x
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:17490
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
is: HMDB00222
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_dd295286_00de_47d4_831e_d615f4fe4707
is encoded by: hsa:3706
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: ITPKA
is: SBO:0000252
is: P23677
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b6b5706b_321d_45df_a955_f31da572560c
is: P30837
type: Species
boundary condition: true
name: ALDH1B1
constant: false
initial concentration: NaN
is encoded by: hsa:219
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM hdd2coa c
is: CHEBI:61526
has only substance units: false
boundary condition: false
name: trans-Hexadec-2-enoyl-CoA
type: Species
initial amount: NaN
is: HMDB03945
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM 5dhf e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
type: Species
constant: false
has only substance units: false
is: HMDB06487
boundary condition: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110040#_2f111fb5_08ab_42be_bef3_78e5142b0bf5
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7371
boundary condition: true
is: SBO:0000252
is: Q9BZX2
name: UCK2

metaR r0638
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110040#
is: SBO:0000176

metaR LNLNCGCRNt
fast: false
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110040#
product: MODEL1310110040#
name: transport into the mitochondria (carnitine)
reversible: false
modifier: MODEL1310110040#

metaR r2521
type: Reaction
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110040#
name: Utilized transport
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110040#
fast: false

metaR DPMVDx
name: diphosphomevalonate decarboxylase
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.1.1.33
fast: false
reversible: false
product: MODEL1310110040#
modifier: MODEL1310110040#

metaR GK1
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.8
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: guanylate kinase (GMP:ATP)
is: SBO:0000176
modifier: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_8495c57d_14ab_4252_a90b_307e85ed60e7
boundary condition: true
initial concentration: NaN
type: Species
is: E5KSL5
is encoded by: hsa:1716
initial amount: NaN
is: SBO:0000252
name: DGUOK
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_88826807_2de0_45ab_8f03_cdad8180b673
is: Q6PII5
constant: false
is encoded by: hsa:84264
is: SBO:0000252
type: Species
boundary condition: true
name: HAGHL
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_c2e8ff34_51eb_42f5_b5c7_6b2bf7e3d589
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:53905
is: SBO:0000252
name: DUOX1
is: Q9NRD9
type: Species
initial concentration: NaN
boundary condition: true

metaR r0202
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaM pail hs n
constant: false
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57880
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b3629249_b676_417c_a411_29b110c13292
is: O75881
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CYP7B1
initial concentration: NaN
is encoded by: hsa:9420
type: Species
initial amount: NaN

metaM octd11ecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: 11-octadecenoylcoa
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB06294
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_472919e9_c3da_4e4c_b842_b8a32ef87029
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:501
is: E7EPT3
has only substance units: false
boundary condition: true
name: ALDH7A1
is: SBO:0000252
initial amount: NaN

metaR r2520
kinetic law: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000

metaR MALTe
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.20
type: Reaction
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
reactant: MODEL1310110040#
fast: false
name: alpha-glucosidase, extracellular
kinetic law: MODEL1310110040#
reversible: false
product: MODEL1310110040#
is described by: ECO:0000269

metaM xol7ah3 c
is: CHEBI:28540
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB12455
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol

http://identifiers.org/biomodels.db/MODEL1310110040#_09fdad67_cf76_459f_8258_bdc8198809c5
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: DGKZ
boundary condition: true
is: B7Z2M9
initial concentration: NaN
is encoded by: hsa:8525
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2610269a_e764_48c5_8e5d_a7641b7bd7b6
constant: false
is: Q9BV79
name: MECR
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51102
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_d7dd6aa4_221c_47ca_ae34_aed32478853b
type: Species
boundary condition: true
is: O00757
is: SBO:0000252
is encoded by: hsa:8789
initial concentration: NaN
name: FBP2
constant: false
initial amount: NaN
has only substance units: false

metaR r0472
product: MODEL1310110040#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaR P45027A1m
product: MODEL1310110040#
fast: false
name: Cytochrome P450 27
modifier: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269

metaR MALtm
is described by: ECO:0000269
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000185
name: malate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF

metaM 5aizc c
is: SBO:0000247
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C04751
is: HMDB06273
is: CHEBI:58564
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: Species
constant: false

metaM hdcecrn m
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
type: Species
name: Hexadecenoyl carnitine
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: HMDB00222
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_3c80b77d_6840_46ce_86b7_da8fd3513a6a
is: Q53H96
initial concentration: NaN
is encoded by: hsa:65263
type: Species
constant: false
name: PYCRL
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR RE0915E
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
name: RE0915
fast: false
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_bfbcb950_27c3_498b_8445_457d7806ce18
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: B3GNT2
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10678

metaM glyc c
name: Glycerol
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
is: C00116
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00131
type: Species
is: CHEBI:17754

metaM lpro m
constant: false
boundary condition: false
name: Lipoylprotein
initial amount: NaN
has only substance units: false
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
initial concentration: 1.0
type: Species
is: CHEBI:15804
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_84ec9c0d_25c9_4695_b711_bb8671d21926
is encoded by: hsa:411
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: ARSB
is: A8K4A0
initial concentration: NaN

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM k e
initial concentration: 1.0
is: CHEBI:29103
constant: false
is: C00238
is: HMDB00586
name: potassium
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_9110f0c1_a9c3_4933_97c6_0b3615ad0bb9
boundary condition: true
is: Q99944
type: Species
is encoded by: hsa:80864
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: EGFL8
initial concentration: NaN

metaR IDOURte
is described by: ECO:0000134
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
name: L-iduronate transport, extracellular
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r0474
kinetic law: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110040#
is described by: ECO:0000000
reversible: true

metaR 4MOPt2im
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
product: MODEL1310110040#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR r0634
fast: false
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110040#
is: SBO:0000176

metaM CE5236 c
is: CHEBI:28002
boundary condition: false
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
initial concentration: 1.0
constant: false

metaR NTD6
reversible: false
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
name: 5'-nucleotidase (dAMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

http://identifiers.org/biomodels.db/MODEL1310110040#_49a5d66b_8277_42ab_82d4_53974b7ada15
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:26275
is: Q6NVY1
name: HIBCH

metaM glyc e
is: HMDB00131
has only substance units: false
is: C00116
boundary condition: false
type: Species
name: Glycerol
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
is: CHEBI:17754
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_faf7d708_ffef_4a57_9c38_0365a9b177ca
is: SBO:0000252
is: Q9Y666
constant: false
name: SLC12A7
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10723

http://identifiers.org/biomodels.db/MODEL1310110040#_31a87cb5_0684_4172_ae07_850cbc0469ff
boundary condition: true
name: _LOC728997_1_c
is encoded by: hsa:LOC728997
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_f29581d3_8c43_4710_80f5_f25b6fa389c9
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:AI656480
name: _AI656480_1_m
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r1156
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
reversible: true

metaM didp n
boundary condition: false
has only substance units: false
constant: false
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
initial concentration: 1.0
name: dIDP
is: SBO:0000247
is: CHEBI:28823
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b9279a7f_41cb_442a_9cac_17088c126d4c
constant: false
type: Species
name: SDHB
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P21912
has only substance units: false
is encoded by: hsa:6390

metaR CRNrtx
is described by: ECO:0000134
is: SBO:0000185
reversible: true
fast: false
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
type: Reaction

metaM k c
is: SBO:0000247
is: CHEBI:29103
constant: false
name: potassium
is: C00238
has only substance units: false
boundary condition: false
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN
type: Species
initial concentration: 1.0

metaR PI45P5P
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000

metaR r0633
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110040#
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_9d2985a4_89e7_4d23_83bb_59b56eb5ebec
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152
has only substance units: false
boundary condition: true
name: PDE9A
is: SBO:0000252
constant: false
type: Species

metaR ACCOAC
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM prostgi2 e
is: HMDB01335
has only substance units: false
initial concentration: 1.0
name: prostaglandin I2(1-)
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57403
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247

metaR FUM
name: fumarase
is: SBO:0000176
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.2

metaR HACD9m
fast: false
product: MODEL1310110040#
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000134
type: Reaction
reversible: true
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_0cecd50c_08e6_475a_bc5b_4c1bf1b7f335
constant: false
is: Q9NR34
name: MAN1C1
is encoded by: hsa:57134
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

metaM crm hs g
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:52639
initial concentration: 1.0
name: N-acylsphingosine
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

http://identifiers.org/biomodels.db/MODEL1310110040#_2c51fb92_af34_40d0_89ea_ca27f87bd1a7
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: P15291
is: SBO:0000252
name: B4GALT1
initial amount: NaN
is encoded by: hsa:2683
constant: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR SO4tl
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)
product: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110040#
fast: false

metaR LEUKTRD4t
name: leukotriene D4 transport
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269

metaR EX ebastine LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ebastine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_7dc66789_50c0_45d2_ac93_1e8a9ea29412
initial amount: NaN
is encoded by: hsa:9060
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: O95340
name: PAPSS2
boundary condition: true
type: Species

metaM Ser Gly Ala X Gly l
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
constant: false
is: CHEBI:36005
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial concentration: 1.0
has only substance units: false
is: HMDB02183
is: SBO:0000247

metaM gt1a hs c
constant: false
name: GT1a
initial concentration: 1.0
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:27691

metaM prostge2 c
constant: false
name: prostaglandin E2(1-)
is: CHEBI:606564
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01220
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaM thcholstoic c
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
is: CHEBI:18402
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

http://identifiers.org/biomodels.db/MODEL1310110040#_ee8dd4b6_2ccb_4598_9e5a_e7d5579c9648
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI761708
is: SBO:0000252
boundary condition: true
type: Species
name: _AI761708_1_m

metaR STRDNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110040#
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c41b13d8_7d08_489b_a55b_dfce7a831cee
is: SBO:0000252
type: Species
name: G6PC2
has only substance units: false
constant: false
is: E9PAX2
is encoded by: hsa:57818
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_c5b35f44_b83b_422d_b626_63e7fbf5ed31
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:765
is: Q5FC00
initial amount: NaN
type: Species
name: CA6
constant: false
has only substance units: false
boundary condition: true

metaM vacccrn m
constant: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Vaccenyl carnitine
is: HMDB06351
has only substance units: false

metaM retn e
type: Species
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01852
initial amount: NaN
initial concentration: 1.0
constant: false

metaR DOPASFt
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reversible: false
name: Dopamine 3-0-sulfate transport (diffusion)
is: SBO:0000185
is described by: ECO:0000000

metaR DESAT18 6
product: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reactant: MODEL1310110040#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ

metaR r0630
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reactant: MODEL1310110040#
is: SBO:0000176

metaM pi e
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
initial amount: NaN
is: C00009
name: hydrogenphosphate
has only substance units: false
constant: false
is: CHEBI:43474
type: Species
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110040#_a4b2dcbf_2bc0_4b3b_9550_b605d5603218
name: NANS
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9NR45
type: Species
is encoded by: hsa:54187
initial amount: NaN
constant: false
has only substance units: false

metaM 5dhf m
name: pentaglutamyl folate (DHF)
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
initial concentration: 1.0
initial amount: NaN

metaR DNDPt8m
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
name: dADP transport via dUDP antiport
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_665729cf_91c9_4eaa_92fb_dbdace6990e4
is: Q9HCQ5
is: SBO:0000252
is encoded by: hsa:50614
name: GALNT9
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM galside hs g
constant: false
name: D-galactosyl-N-acylsphingosine
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR FORtr
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
name: FOR transporter, endoplasmic reticulum
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_51aa8501_6368_49ac_855d_4af033a919fa
is: P24666
name: ACP1
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:52
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_336b95b8_52e4_45d8_b1c7_0e9d16b351f0
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: GPX1
initial concentration: NaN
is encoded by: hsa:2876
boundary condition: true

metaR C101CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_4ebf03b2_71f8_4fdb_be99_257b18c4fe3d
is: SBO:0000252
is: E5KSL6
type: Species
name: DGUOK
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:1716

metaM 5dhf l
initial amount: NaN
type: Species
name: pentaglutamyl folate (DHF)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: HMDB06487
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_1d6d663b_56d9_480f_8c7c_ebb4c7568588
type: Species
is: SBO:0000252
is: B2R6S5
name: CMPK1
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:51727
initial concentration: NaN
constant: false

metaM CE0693 m
is: HMDB11123
type: Species
has only substance units: false
initial concentration: 1.0
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial amount: NaN
is: SBO:0000247
constant: false

metaR HDECEACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1c3a81d9_049f_467b_bae8_dbab4328a6a2
name: ST3GAL3
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6487
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_196943b2_7206_4c79_931f_443a195e9375
has only substance units: false
name: ASAH1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:427
initial amount: NaN
is: Q13510

metaR CHATn
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.6
is described by: ECO:0000269
reversible: true
name: Choline O-acetyltransferase
modifier: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_b96ac395_5766_4a67_9f56_10f289119b8a
type: Species
name: PFAS
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5198
is: Q6P4B4
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r0480
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
type: Reaction

metaM camp c
is: CHEBI:58165
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 3',5'-cyclic AMP(1-)
type: Species
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
is: HMDB00058
has only substance units: false

metaM pi g
constant: false
is: HMDB00973
is: SBO:0000247
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:43474

metaR SGALSIDEtl
name: sgalside hs intracellular transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM retn c
type: Species
name: all-trans-retinoate
boundary condition: false
has only substance units: false
is: CHEBI:35291
is: SBO:0000247
initial concentration: 1.0
is: HMDB01852
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false

metaR DESAT18 4
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110040#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction

metaM pail hs c
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
initial amount: NaN
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57880
is: SBO:0000247

metaM arachd c
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:32395
type: Species
initial concentration: 1.0
is: HMDB01043
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110040#_80475eae_9fda_49b5_8c2b_9cc11b15e27d
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: PDE9A
initial concentration: NaN
constant: false
is encoded by: hsa:5152
has only substance units: false

metaR NDPK8
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110040#
type: Reaction
fast: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_400debdd_9ad0_4448_9185_659085c73506
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:211
constant: false
is: P13196
boundary condition: true
type: Species
has only substance units: false
name: ALAS1

metaR TYRTA
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110040#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
name: tyrosine transaminase
fast: false

metaR r1434
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110040#
is: SBO:0000185
fast: false
name: Transport reaction

metaR CSNAT2x
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.137
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
product: MODEL1310110040#
type: Reaction

metaM h2o2 x
initial concentration: 1.0
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
boundary condition: false
is: C00027
is: HMDB03125
has only substance units: false
initial amount: NaN
type: Species
name: Hydrogen peroxide
is: CHEBI:16240

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR CAt7r
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
type: Reaction
name: calcium / sodium antiporter (1:3), reversible
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
is: SBO:0000185

metaM mpdol L c
type: Species
is: SBO:0000247
has only substance units: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:18396
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110040#_1e62cc0a_6d6b_4e89_be8e_2e2f0de31d04
is encoded by: hsa:5321
type: Species
boundary condition: true
is: P47712
constant: false
name: PLA2G4A
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM q10h2 e
is: http://identifiers.org/pubchem.compound/6504740
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB13111
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR GALK
name: galactokinase
is described by: ECO:0000000
modifier: MODEL1310110040#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/2.7.1.157
reversible: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.6
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_eebc75d2_8cd8_4af2_9767_fcf0ba74e77c
boundary condition: true
type: Species
is: Q4F7X0
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:114
name: ADCY8
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a645a241_c086_40fb_83ff_ba2311fd919a
initial concentration: NaN
boundary condition: true
is: Q8TF71
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: SLC16A10
is: SBO:0000252
is encoded by: hsa:117247

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR r1433
reversible: false
product: MODEL1310110040#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110040#

metaM gt1a hs g
constant: false
is: CHEBI:27691
initial amount: NaN
boundary condition: false
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
has only substance units: false
name: GT1a
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR NDPK9
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:IDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
modifier: MODEL1310110040#

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
constant: false
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:58335
initial amount: NaN

metaM uri e
is: HMDB00296
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
has only substance units: false
constant: false
type: Species
is: C00299
is: SBO:0000247
name: Uridine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_4dd650f1_2950_4b73_9ad3_9bd39f4bef6d
name: _AI091231_1_c
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI091231
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_3c99808e_4951_4828_8b09_23661afbb33f
is encoded by: hsa:2582
initial amount: NaN
is: Q38G75
has only substance units: false
boundary condition: true
type: Species
constant: false
name: GALE
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_22c9b3d1_fd8b_4881_96aa_d4ed34fbf5aa
boundary condition: true
name: ADH1C
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: P00326
is encoded by: hsa:126
is: SBO:0000252

metaM cs a deg5 l
initial amount: NaN
constant: false
type: Species
is: CHEBI:15936
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM galside hs c
constant: false
is: CHEBI:12947
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR TTDCAtr
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
is described by: ECO:0000269
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
name: tetradecanoate (transport)

metaM HC01496 m
is: SBO:0000247
name: 2-Amino-3-oxoadipate
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false
is: CHEBI:28095
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_89c2da8d_d635_49dd_a418_0bab80110e98
is encoded by: hsa:9435
name: CHST2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q9Y4C5
boundary condition: true

metaM q10h2 c
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740
type: Species
boundary condition: false
name: Ubiquinol-10
initial concentration: 1.0
has only substance units: false
is: HMDB13111

metaR ACACt2m
is described by: ECO:0000269
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
is: SBO:0000185
fast: false
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
reversible: true
reactant: MODEL1310110040#
product: MODEL1310110040#

metaR SARDHm
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.5.99.1
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
type: Reaction
fast: false
name: Sarcosine dehydrogenase (m)
is: SBO:0000176
is described by: ECO:0000269
reversible: false

metaM retinal 11 cis c
name: 11-cis-retinal
is: CHEBI:16066
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
is: HMDB02152
is: SBO:0000247
type: Species
has only substance units: false
constant: false

metaR r1431
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_312387aa_9eec_4fb1_9d4f_f0a9997041d8
is encoded by: hsa:65985
initial concentration: NaN
name: AACS
is: Q86V21
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_f762ec4a_2b63_4374_a4ef_ee009d54302d
has only substance units: false
name: OCRL
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4952
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM gt1a hs e
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
initial amount: NaN
is: CHEBI:27691
has only substance units: false
name: GT1a
initial concentration: 1.0
type: Species

metaR G12MT1 L
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
type: Reaction
reversible: false
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_f29237f9_d299_4f35_901e_d73e8c3964f0
is: SBO:0000252
boundary condition: true
is: O95299
is encoded by: hsa:4705
constant: false
has only substance units: false
initial concentration: NaN
name: NDUFA10
initial amount: NaN
type: Species

metaM prostge2 e
name: prostaglandin E2(1-)
constant: false
boundary condition: false
is: HMDB01220
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564

metaM uri c
name: Uridine
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
constant: false
is: CHEBI:16704
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00299
is: HMDB00296

metaM pi c
notes: FORMULA: HO4P CHARGE: -2
constant: false
is: CHEBI:43474
initial concentration: 1.0
type: Species
name: hydrogenphosphate
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00009
is: HMDB00973
is: SBO:0000247

metaM gdp e
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
is: SBO:0000247
type: Species
is: CHEBI:58189
initial amount: NaN
is: HMDB01201
initial concentration: 1.0
has only substance units: false

metaM pi n
name: hydrogenphosphate
initial concentration: 1.0
type: Species
constant: false
is: HMDB00973
initial amount: NaN
is: CHEBI:43474
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaM c3dc e
constant: false
type: Species
notes: FORMULA: C10H16NO6 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02095
has only substance units: false
name: malonyl carnitine

metaR r1583
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#

metaM ksi deg33 l
constant: false
boundary condition: false
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate I, degradation product 33
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_43aaedd7_43e2_4e5a_a882_c4d99bb1740b
constant: false
is encoded by: hsa:219
initial amount: NaN
is: P30837
name: ALDH1B1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_3687e29f_add5_4cc7_b2b0_945eec7858f2
is encoded by: hsa:5169
initial amount: NaN
initial concentration: NaN
type: Species
is: Q308M7
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ENPP3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_630fbed0_bf17_424c_bd1c_108e817ebe16
has only substance units: false
constant: false
is: P43005
initial concentration: NaN
name: SLC1A1
type: Species
initial amount: NaN
is encoded by: hsa:6505
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_cc53e7aa_2c07_4379_9b8c_75cc85da4327
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: P20132
name: SDS
boundary condition: true
is encoded by: hsa:10993

metaM galside hs l
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:12947
initial amount: NaN

metaM pi m
initial concentration: 1.0
is: HMDB00973
is: SBO:0000247
initial amount: NaN
is: C00009
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
name: hydrogenphosphate
type: Species
constant: false
is: CHEBI:43474

metaR S6TASE13ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110040#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110040#
is described by: ECO:0000000

metaR PPA
reactant: MODEL1310110040#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase

metaR DMNONCOACRNCPT1
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
reversible: true
name: DMNONCOACRNCPT1

metaR RE0512M
type: Reaction
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
kinetic law: MODEL1310110040#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_3fa6ba17_7d08_450c_b58b_6256d2fc11dd
is: SBO:0000297
type: Species
name: NME1:NME2
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4830
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c37caaeb_c911_4fdc_a04b_3c27918945e6
initial concentration: NaN
boundary condition: true
name: SLC5A5
type: Species
initial amount: NaN
is: Q92911
is encoded by: hsa:6528
is: SBO:0000252
constant: false
has only substance units: false

metaM gdp c
boundary condition: false
is: C00035
constant: false
name: GDP
type: Species
is: CHEBI:58189
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01201

metaM h2o2 m
is: SBO:0000247
name: Hydrogen peroxide
type: Species
is: CHEBI:16240
is: HMDB03125
has only substance units: false
is: C00027
boundary condition: false
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
initial amount: NaN

metaM c3dc c
notes: FORMULA: C10H16NO6 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: malonyl carnitine
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB02095

http://identifiers.org/biomodels.db/MODEL1310110040#_764f8abd_ad9f_4bdc_839b_96235ee1e189
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: CHST6
is: Q9GZX3
initial amount: NaN
is encoded by: hsa:4166
initial concentration: NaN
constant: false

metaR r1581
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 2pg c
is: HMDB03391
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
is: C00631
has only substance units: false
initial concentration: 1.0
is: CHEBI:58289
is: http://identifiers.org/pubchem.compound/3904
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: D-Glycerate 2-phosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5cdc4381_3a9e_4da9_a603_879aedc718dc
name: _AI915649_1_c
constant: false
is: SBO:0000252
is encoded by: hsa:AI915649
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaM andrstandn r
initial concentration: 1.0
has only substance units: false
constant: false
name: 5alpha-androstane-3,17-dione
is: CHEBI:15994
is: HMDB00899
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674

metaR CDS
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
fast: false
reactant: MODEL1310110040#
name: phosphatidate cytidylyltransferase
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_cea9b431_dbdb_44dc_a559_99103f13fd91
name: ECH1
initial amount: NaN
is: Q13011
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1891
boundary condition: true
is: SBO:0000252
constant: false

metaR N4Tg
product: MODEL1310110040#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
type: Reaction
reversible: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR PROt4 2 r
reversible: true
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110040#
type: Reaction
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110040#
is described by: ECO:0000006

metaR r1580
reactant: MODEL1310110040#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110040#

metaM ebastineoh r
initial concentration: 1.0
is: HMDB01191
constant: false
notes: FORMULA: C32H39NO3 CHARGE: 0
is: CHEBI:17625
name: hydroxylated ebastine
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_1e0270c0_bf15_4d4f_9b24_6ce34697cb33
boundary condition: true
name: PDHX
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:8050
type: Species
initial concentration: NaN
initial amount: NaN
is: O00330

metaM fgam c
is: C04376
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01308
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
boundary condition: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: SBO:0000247
is: CHEBI:58426
constant: false
type: Species

metaR 4PYRDX
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: 4-Pyridoxal secretion
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)

http://identifiers.org/biomodels.db/MODEL1310110040#_40ff94d0_e396_4104_8895_2659376e6842
type: Species
is encoded by: hsa:AGPAT7
name: _AGPAT7_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR GALC
kinetic law: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
name: Galactocerebrosidase
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.46
is: SBO:0000176
type: Reaction

metaR SMPD4
is: SBO:0000176
name: sphingomyelinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_da565855_5628_4672_8eaa_42f218d9cc17
is: SBO:0000252
initial concentration: NaN
is: P35218
is encoded by: hsa:763
type: Species
constant: false
has only substance units: false
name: CA5A
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_1a12d62d_eefa_425a_b8a3_762cccf9645a
is encoded by: hsa:100287639
initial amount: NaN
initial concentration: NaN
name: _100287639_1_c
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM cdp c
name: CDP
has only substance units: false
is: C00112
type: Species
constant: false
initial amount: NaN
is: HMDB01546
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069

http://identifiers.org/biomodels.db/MODEL1310110040#_2247b313_612b_4700_8824_60b482bb7f32
initial concentration: NaN
has only substance units: false
name: GCDH
constant: false
is encoded by: hsa:2639
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_ffb585b5_154e_4c45_94b9_3de3c41c8531
has only substance units: false
initial concentration: NaN
is: P51648
type: Species
is encoded by: hsa:224
initial amount: NaN
is: SBO:0000252
name: ALDH3A2
constant: false
boundary condition: true

metaM leuktrD4 e
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: Leukotriene D4
constant: false
is: HMDB03080

metaM hdd2coa x
initial amount: NaN
is: CHEBI:61526
is: HMDB03945
boundary condition: false
name: (E)-hexadec-2-enoyl-CoA(4-)
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
type: Species

metaR LNLNCACRNt
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_94c9fbb3_7e77_47b3_8d12_5452de868945
initial concentration: NaN
type: Species
is: P38571
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3988
name: LIPA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_61764b87_2e32_46cc_ab30_48b5b598e4db
boundary condition: true
name: PDE6G
is: P18545
is encoded by: hsa:5148
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_446c5f8d_bd28_4cf3_8553_aec3903ea276
constant: false
name: SLC25A10
initial concentration: NaN
is encoded by: hsa:1468
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: Q9UBX3
has only substance units: false

metaR FAOXC142C142OHm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a8817f0e_7d4c_4594_91e1_d3f8bbf4e1ce
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q06203
type: Species
is encoded by: hsa:5471
name: PPAT

metaM gsn c
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
initial concentration: 1.0
boundary condition: false
type: Species
name: Guanosine
is: C00387
is: SBO:0000247
is: CHEBI:16750

http://identifiers.org/biomodels.db/MODEL1310110040#_e2ba4129_64fc_4164_a2ab_53d79dec4154
name: GAL3ST1
constant: false
is encoded by: hsa:9514
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q99999
initial concentration: NaN

metaM arachd e
is: CHEBI:32395
is: HMDB01043
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
initial concentration: 1.0

metaR IDPtn
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
fast: false
name: IDP nuclear transport

metaR BTNPL
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110040#
name: holocarboxylase synthestase (biotin protein ligase)
is: SBO:0000176
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
type: Reaction
fast: false

metaR PAIL HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
name: phosphatidylinositol nuclear transport (diffusion)

metaR 3HLYTCL
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is: SBO:0000176
fast: false
modifier: MODEL1310110040#
name: 3-Hydroxy-L-tyrosine carboxy-lyase
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_f1589762_6d0e_469a_8cdb_e13afcc6455d
constant: false
is encoded by: hsa:2618
type: Species
is: P22102
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GART
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_d0b114b0_d94c_4a72_a7de_b6218f22306f
type: Species
name: SULT1A3
is encoded by: hsa:6818
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q1ET61
initial amount: NaN
boundary condition: true

metaM Asn X Ser Thr r
name: protein-linked asparagine residue (N-glycosylation site)
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
notes: FORMULA: XH CHARGE: 0
constant: false
has only substance units: false
is: C01342
is: SBO:0000247
is: HMDB00051

http://identifiers.org/biomodels.db/MODEL1310110040#_6626f923_3bd2_40b7_bf99_c28560e3bc95
is: SBO:0000252
name: MSMO1
type: Species
is encoded by: hsa:6307
boundary condition: true
initial amount: NaN
is: A8MYF6
has only substance units: false
initial concentration: NaN
constant: false

metaM HC01842 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: Phosphodimethylethanolamine
is: CHEBI:31997
initial amount: NaN
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247

metaM pi l
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: SBO:0000247
initial amount: NaN
is: CHEBI:43474
has only substance units: false
initial concentration: 1.0
is: HMDB00973
type: Species
constant: false

metaR HISTAtu
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110040#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#
name: Histamine uniport
is described by: ECO:0000269
modifier: MODEL1310110040#
fast: false

metaM cdp e
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01546
name: CDP(3-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
initial concentration: 1.0

metaM HC00695 m
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
type: Species
constant: false
name: S-Succinyldihydrolipoamide
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17432

metaR FBP
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.11
fast: false
modifier: MODEL1310110040#
name: fructose-bisphosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
product: MODEL1310110040#
type: Reaction
reversible: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaM dmnoncoa c
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
type: Species
name: 4,8 dimethylnonanoyl-CoA
initial concentration: 1.0
is: HMDB11604
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_64dbf908_1471_4c01_9f79_372c95e2f941
boundary condition: true
has only substance units: false
type: Species
name: ALDH3B2
is: SBO:0000252
is: P48448
constant: false
initial concentration: NaN
is encoded by: hsa:222
initial amount: NaN

metaR CSBPASEly
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

metaR NACHEX25ly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110040#

metaR CSNAT2m
is: SBO:0000176
product: MODEL1310110040#
reversible: true
type: Reaction
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#

metaM 3hpcoa m
initial amount: NaN
name: 3-hydroxypropanoyl-CoA(4-)
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
type: Species
is: CHEBI:58528
is: HMDB06807

metaM ocdececrn c
type: Species
boundary condition: false
is: HMDB06351
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
initial concentration: 1.0
name: 11-octadecenoyl carnitine
has only substance units: false
is: SBO:0000247

metaR r0741
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
type: Reaction
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_2cc6938c_ab68_42f7_ad0f_0f77cc01e5a0
is encoded by: hsa:5144
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q08499
initial concentration: NaN
constant: false
name: PDE4D

metaM hxan e
constant: false
is: SBO:0000247
name: hypoxanthine
initial amount: NaN
boundary condition: false
is: HMDB00157
has only substance units: false
is: CHEBI:17368
initial concentration: 1.0
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262

metaM ksi deg14 l
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
type: Species
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
name: keratan sulfate I, degradation product 14

metaM dhcrm hs c
constant: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: dihydroceramide
is: CHEBI:31488

http://identifiers.org/biomodels.db/MODEL1310110040#_5c1a97ba_095b_41f7_af5b_c6623f9582de
is: SBO:0000252
name: GUCY2C
type: Species
has only substance units: false
is: P25092
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2984

metaR UGCG
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.80
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
reversible: false
name: Ceramide glucosyltransferase

metaR C10CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_67da2eef_ef57_4e9d_bcd6_95adde55fb80
is encoded by: hsa:23428
constant: false
name: SLC7A8:SLC3A2
initial concentration: NaN
boundary condition: true
has part: Q86U05
type: Species
is: SBO:0000297
has only substance units: false
initial amount: NaN

metaM 4hpro LT m
is: SBO:0000247
type: Species
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:18095
name: trans-4-hydroxy-L-proline

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaM hdcoa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)
boundary condition: false
is: SBO:0000247

metaR MAN6PI
reactant: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
modifier: MODEL1310110040#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.8

metaR G14T17g
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM arachd r
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32395
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
type: Species
name: arachidonate

metaR r0377
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
reversible: false
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
kinetic law: MODEL1310110040#

metaM ksi pre17 g
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 17
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaR AG13T8g
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110040#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_0527a3eb_4f70_4f83_8435_6355ff151bf8
constant: false
name: FASN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P49327
is encoded by: hsa:2194
type: Species
initial amount: NaN

metaR r0731
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_2d36114b_493f_4172_b5b6_a5e0aa443b3c
type: Species
name: GGH
is encoded by: hsa:8836
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: Q92820

metaR CITt4 2
fast: false
name: citrate transport via sodium symport
is described by: ECO:0000269
kinetic law: MODEL1310110040#
is: SBO:0000185
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction

metaR GLACter
is: SBO:0000185
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
reactant: MODEL1310110040#
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110040#
fast: false

metaR HXPRT
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)

http://identifiers.org/biomodels.db/MODEL1310110040#_4c45de3f_1425_4c3a_93a9_2f91ae5ea26e
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9HAB8
type: Species
boundary condition: true
constant: false
is encoded by: hsa:79717
name: PPCS

http://identifiers.org/biomodels.db/MODEL1310110040#_cd641e78_0978_4127_809f_fe5634cd81e7
is: Q9BY32
has only substance units: false
is: SBO:0000252
name: ITPA
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:3704

metaR HPDCAt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
fast: false

metaR HSAT3ly
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaM for e
is: HMDB00142
type: Species
name: formate
boundary condition: false
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
has only substance units: false
is: CHEBI:15740
initial amount: NaN
initial concentration: 1.0

metaM e4hglu m
initial amount: NaN
name: erythro-4-hydroxy-L-glutamate(1-)
is: HMDB02273
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: CHEBI:6331

metaM estradiol c
boundary condition: false
type: Species
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: estradiol
has only substance units: false
constant: false
is: HMDB00151
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110040#_a9fa3933_7e3d_4476_9f8c_931b77f8c34d
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:H77542
boundary condition: true
has only substance units: false
name: _H77542_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_d4584461_993e_4b73_9775_f2f8c75fffb9
initial concentration: NaN
name: NAGK
is: Q9UJ70
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:55577
constant: false
initial amount: NaN
boundary condition: true

metaM pydx e
type: Species
is: C00250
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01545
name: Pyridoxal
is: CHEBI:17310
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
boundary condition: false
initial amount: NaN

metaM HC01399 x
initial amount: NaN
is: CHEBI:27466
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
type: Species
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
constant: false

metaR r0730
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000

metaR r2380
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110040#

metaM hcys L c
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:17588
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial concentration: 1.0
name: L-homocysteine
is: HMDB00742

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM Asn X Ser Thr l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00051
is: SBO:0000247
is: C01342
constant: false
name: protein-linked asparagine residue (N-glycosylation site)
notes: FORMULA: XH CHARGE: 0
is: CHEBI:28938

metaR r1588
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_95d7b476_8ffb_449d_91a9_4311cc7a9a35
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:65263
initial amount: NaN
initial concentration: NaN
type: Species
name: PYCRL
is: Q53H96

metaR DGSNtm
type: Reaction
reversible: true
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
name: deoyguanosine transport in mitochondria
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_8a2a363b_4c9d_4fe2_8ff4_3fdbd99caa59
constant: false
has only substance units: false
name: SLC7A11
is: Q9UPY5
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23657

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_6fd7770f_9227_4e5e_a7cd_bf8b457c8800
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:57835
initial concentration: NaN
name: SLC4A5
is: Q9BY07

metaM prpp e
is: HMDB00280
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false

metaM 3mop c
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00491
constant: false
boundary condition: false
is: CHEBI:28654
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r0733
reversible: false
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaM bilglcur r
boundary condition: false
has only substance units: false
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_7bd3373e_22ea_4171_bd95_25209a2fb7bd
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: NMRK1
is encoded by: hsa:54981
constant: false
boundary condition: true
is: SBO:0000252
is: Q9NWW6

metaM estradiol e
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial concentration: 1.0
name: estradiol
constant: false
has only substance units: false
is: HMDB00151
is: CHEBI:16469

metaM biliverd c
initial amount: NaN
is: CHEBI:57991
boundary condition: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB01008
name: biliverdin(2-)
has only substance units: false

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: true

metaM ethamp r
is: HMDB00224
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: O-phosphonatoethanaminium(1-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:58190

metaM pi x
initial concentration: 1.0
initial amount: NaN
is: HMDB00973
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: SBO:0000247
type: Species
is: CHEBI:43474
name: hydrogenphosphate
boundary condition: false

metaM for c
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15740
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
name: Formate
type: Species
initial concentration: 1.0

metaM thcholstoic r
constant: false
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: HMDB03873
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species

metaM pydx c
type: Species
initial concentration: 1.0
is: C00250
has only substance units: false
is: SBO:0000247
constant: false
name: Pyridoxal
is: HMDB01545
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
boundary condition: false
is: CHEBI:17310
initial amount: NaN

metaR Htr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: true
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
type: Reaction

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM cspg e e
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
initial amount: NaN
is: CHEBI:16040
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
type: Species
is: HMDB00630

metaM 3ddcrn e
has only substance units: false
boundary condition: false
type: Species
constant: false
is: C02838
is: SBO:0000247
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN
notes: FORMULA: C19H37NO5 CHARGE: 0
is: HMDB00791
initial concentration: 1.0

metaR r0732
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110040#

metaM leuktrD4 c
name: Leukotriene D4
initial concentration: 1.0
is: CHEBI:28666
has only substance units: false
is: HMDB03080
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_5919be8f_92d9_4684_87d4_b45d683d594e
name: SLC35A2
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: P78381
is encoded by: hsa:7355
is: SBO:0000252
initial amount: NaN

metaR DM fol
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_3d857377_bed2_46d3_a447_2b28b3920006
constant: false
type: Species
is encoded by: hsa:4598
initial amount: NaN
name: MVK
has only substance units: false
boundary condition: true
is: B2RDU6
initial concentration: NaN
is: SBO:0000252

metaM 35cgmp c
is: HMDB01314
has only substance units: false
is: CHEBI:57746
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
initial concentration: 1.0
initial amount: NaN
name: 3',5'-cyclic GMP(1-)

metaR LEUTAm
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
name: leucine transaminase, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_67ea176d_3cd8_44ab_b602_76226758f15c
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI971036
has only substance units: false
constant: false
name: _AI971036_1_c
initial amount: NaN

metaR AKR1C41
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225

metaM paps c
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
type: Species
initial concentration: 1.0
constant: false
is: HMDB01134
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaR RAI1
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: retinal isomerase (11-cis)
is: SBO:0000176
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
fast: false

metaR r2537
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Utilized transport

metaM HC02204 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
type: Species
is: CHEBI:27624
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-b1
initial concentration: 1.0

metaM cspg e l
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: HMDB02183
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: CHEBI:36005
type: Species
is: SBO:0000247
constant: false

metaR r1586
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
is: SBO:0000185

metaR r0735
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110040#
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000

metaR NDPK8n
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: true
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

metaM arachdcoa c
is: HMDB06523
initial concentration: 1.0
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
name: arachidonoyl-CoA(4-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57368
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_14d49de9_1380_48a3_bdb1_8d579a06c55e
boundary condition: true
constant: false
is: Q96CD2
type: Species
is encoded by: hsa:60490
initial amount: NaN
initial concentration: NaN
name: PPCDC
has only substance units: false
is: SBO:0000252

metaR r2385
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_78658227_12b0_4050_bbc0_2bec3d4e9b24
has only substance units: false
is encoded by: hsa:9187
type: Species
is: SBO:0000252
constant: false
is: B4DUG1
name: SLC24A1
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM glx x
is: SBO:0000247
is: CHEBI:36655
name: glyoxylate
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_a9802d23_827a_4ec6_8cae_29e0de2e7e2d
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA664770
name: _AA664770_1_m
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species

metaM 3mop e
is: HMDB00491
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM prpp c
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: CHEBI:58017
is: HMDB00280
is: C00119
initial amount: NaN
type: Species
constant: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r1298
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
name: Vesicular transport
kinetic law: MODEL1310110040#

metaM C02528 c
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
type: Species
is: HMDB00518
has only substance units: false
is: CHEBI:36234

metaR r1587
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pi r
name: hydrogenphosphate
boundary condition: false
is: C00009
is: HMDB00973
has only substance units: false
is: CHEBI:43474
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_78d9c8f1_0935_4410_a88d_6bc028ed0353
has only substance units: false
boundary condition: true
is: Q9BY49
initial amount: NaN
constant: false
name: PECR
initial concentration: NaN
is encoded by: hsa:55825
is: SBO:0000252
type: Species

metaR EX 34hpp
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_4c5d9125_b7ed_4f03_9b1f_3cdde27df385
is encoded by: hsa:27306
has only substance units: false
initial concentration: NaN
constant: false
is: O60760
boundary condition: true
name: HPGDS
type: Species
is: SBO:0000252
initial amount: NaN

metaM ptdcacrn m
initial concentration: 1.0
name: pendtadenoyl carnitine
is: SBO:0000247
type: Species
constant: false
is: CHEBI:15811
has only substance units: false
initial amount: NaN
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
boundary condition: false
is: HMDB01721

metaR r0734
product: MODEL1310110040#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
fast: false
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110040#

metaR 3AIB Dtm
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110040#
name: transport of 3aib_D into mitochondria
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:

metaR r0629
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reactant: MODEL1310110040#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.22

metaR r2384
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110040#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110040#

metaM HC02204 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
name: prostaglandin-b1
type: Species
is: CHEBI:27624
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR CYTK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: cytidylate kinase (dCMP,GTP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110040#
reversible: true
fast: false
modifier: MODEL1310110040#

metaR BUTt2r
name: Butyrate transport via proton symport, reversible
reactant: MODEL1310110040#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#

metaR r1299
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
name: Vesicular transport
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110040#

metaR r1584
kinetic law: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
type: Reaction
reversible: true

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110040#
name: bilirubin transport via bicarbonate countertransport
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
fast: false
reversible: true
type: Reaction

metaR r2539
fast: false
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000185
reversible: true

metaM cdp n
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
initial amount: NaN
is: CHEBI:58069
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01546

metaR GLUt7l
fast: false
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
name: Glutamate transport, lysosomal
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#

metaM acgal1p c
initial concentration: 1.0
is: CHEBI:55404
boundary condition: false
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
name: N-Acetyl-D-galactosamine 1-phosphate
is: HMDB06480
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_35ee5d1c_97db_4ad7_b6a6_672eead57a4f
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q13057
name: COASY
type: Species
is encoded by: hsa:80347
boundary condition: true

metaM itaccoa m
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
name: itaconyl-CoA(5-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB03377
is: CHEBI:57381
type: Species
constant: false
is: SBO:0000247

metaM dcmp c
initial amount: NaN
initial concentration: 1.0
name: dCMP
constant: false
is: CHEBI:57566
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: SBO:0000247
is: C00239
boundary condition: false
is: HMDB01202
type: Species

metaM cdp m
initial amount: NaN
name: CDP(3-)
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
constant: false
is: CHEBI:58069
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaR THRGLYexR
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000304
reactant: MODEL1310110040#
reversible: true
is: SBO:0000185
name: L-threonine/glycine reversible exchange
fast: false

metaR KHK
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
reversible: false
name: ketohexokinase
is version of: http://identifiers.org/ec-code/2.7.1.3
fast: false
kinetic law: MODEL1310110040#

metaR r1585
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#

metaM hLkynr c
boundary condition: false
has only substance units: false
is: HMDB11631
constant: false
name: 3-hydroxy-L-kynurenine
is: CHEBI:17380
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
name: sialidase, lysosomal
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110040#
is: SBO:0000176

metaR r2538
is: SBO:0000185
name: Utilized transport
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR FAOXC16C16OHm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_46e1be6c_9bbb_4eeb_886d_b6b0c545d665
is encoded by: hsa:2531
boundary condition: true
is: Q06136
name: KDSR
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM paps g
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: HMDB01134
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: CHEBI:58339
type: Species

metaR LSTO2r
is described by: ECO:0000269
fast: false
product: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110040#
name: Lathosterol oxidase

metaR r2382
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR S6TASE12ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_01ba2da2_6a09_4d99_a283_c3333f92f006
is: Q92903
has only substance units: false
type: Species
is: SBO:0000252
name: CDS1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1040
constant: false

metaR PPCOACm
is: SBO:0000176
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.4.1.3
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reversible: false
name: Propionyl-CoA carboxylase, mitochondrial

metaR r1863
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM L2aadp c
boundary condition: false
is: HMDB00510
is: CHEBI:58672
type: Species
is: SBO:0000247
constant: false
name: L-2-aminoadipate(1-)
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
initial amount: NaN

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_fabba136_08bc_4215_a4ef_e4fabc61ea18
type: Species
constant: false
is: Q7L266
is: SBO:0000252
name: ASRGL1
initial concentration: NaN
is encoded by: hsa:80150
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r0739
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110040#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

metaR S6T4g
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110040#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110040#

metaR NDPK4n
type: Reaction
product: MODEL1310110040#
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110040#
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear

metaM ocdececrn m
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: 11-octadecenoyl carnitine
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
initial concentration: 1.0

metaM ebastineoh c
type: Species
is: CHEBI:17625
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01191
constant: false
initial concentration: 1.0
notes: FORMULA: C32H39NO3 CHARGE: 0
name: hydroxylated ebastine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9649c468_9de2_4ce9_9f35_a4ca6aec38d5
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:223
name: ALDH9A1
boundary condition: true
initial concentration: NaN
is: P49189
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_14d24ebd_f231_482d_a392_e9414a3a3c9a
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: _AI222095_1_m
boundary condition: true
is encoded by: hsa:AI222095

metaR r2389
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaR S3TASE2ly
fast: false
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR Htg
kinetic law: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
name: proton diffusion (Golgi)
reactant: MODEL1310110040#
fast: false

metaR RE1526M
modifier: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
name: RE1526
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaR SGALSIDEtg
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
name: sgalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110040#

metaR ACNMLr
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
fast: false
name: N-Acetylneuraminate lyase (reversible)
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110040#_8e05f4e7_f80f_431f_a455_52f35e042723
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:43
type: Species
is: SBO:0000252
name: ACHE
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_39369de7_68f4_4dc9_b763_766dc9246292
name: PDE9A
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5152

metaM hdcoa c
boundary condition: false
is: HMDB06532
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: SBO:0000247

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
has only substance units: false
is: HMDB00725
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaR CSNt
type: Reaction
name: cytosine transport via facilated diffusion
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

metaR NACHEX2ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110040#
type: Reaction

metaM dgsn m
name: Deoxyguanosine
is: HMDB00085
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
type: Species
is: C00330
is: SBO:0000247
is: CHEBI:17172
constant: false
initial concentration: 1.0

metaR DNDPt11m
reversible: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dGDP antiport

http://identifiers.org/biomodels.db/MODEL1310110040#_ff691d9b_8236_4fab_91e1_dd61482a44b8
type: Species
constant: false
boundary condition: true
is encoded by: hsa:AL048840
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AL048840_1_c

metaR GT1Atg
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: gt1a hs intracellular transport
product: MODEL1310110040#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_a8ab27a3_3742_4b3f_a09b_88cf19ec81f0
initial amount: NaN
is encoded by: hsa:89874
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: SLC25A21
constant: false
is: G3V4L5

metaM 3hodcoa m
name: (S)-3-Hydroxyoctadecanoyl-CoA
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
constant: false
is: HMDB06294
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR ARAB Lt
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110040#

metaR r2532
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
product: MODEL1310110040#
type: Reaction
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000

metaR r2388
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110040#_6bfef908_b5c8_4d9b_8c93_54af8b49837f
type: Species
constant: false
has only substance units: false
name: _AW277253_1_c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AW277253
is: SBO:0000252
boundary condition: true

metaR r0488
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:

metaR PMANM
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110040#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.8
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: phosphomannomutase
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_98de90f7_843e_4f2b_a509_0537712ea26e
is encoded by: hsa:4709
name: NDUFB3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: Q6IB80
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_9a202d3e_fa06_4184_840f_f60bdea006d3
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P16260
constant: false
initial amount: NaN
is encoded by: hsa:8034
type: Species
name: SLC25A16
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_2f01e090_fb86_49b3_aaf0_8525d98ffdfd
boundary condition: true
has only substance units: false
initial amount: NaN
name: TRNT1
is encoded by: hsa:51095
is: SBO:0000252
type: Species
is: Q96Q11
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ae204014_19ae_474f_8a36_4abda13a36df
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: P40394
name: ADH7
is encoded by: hsa:131

metaR GGH 6THFe
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6THF), extracellular
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
reactant: MODEL1310110040#
type: Reaction

metaR r2387
is: SBO:0000185
reversible: false
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction

metaR r2535
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110040#

metaM ksi deg36 l
is: HMDB00143
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
has only substance units: false
name: keratan sulfate I, degradation product 36
is: SBO:0000247
is: CHEBI:12936

metaM CE2431 m
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
has only substance units: false
boundary condition: false
is: SBO:0000247
name: cis-deca-4-enoyl-CoA
is: CHEBI:57795
initial concentration: 1.0
initial amount: NaN
type: Species

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR RE2660C
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: true
is: SBO:0000176
name: RE2660
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_5f652a36_69a4_49e7_b9d7_949d8c0e81e2
initial amount: NaN
is encoded by: hsa:2519
initial concentration: NaN
name: FUCA2
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q9BTY2

metaM C02528 r
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
boundary condition: false
is: CHEBI:36234
name: chenodeoxycholate

metaR r0627
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_296b12e2_3f4b_434b_8eb1_bb7862163c34
constant: false
is: Q96NR8
initial amount: NaN
is encoded by: hsa:145226
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: RDH12
type: Species
boundary condition: true

metaR ACNAMlt
modifier: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
product: MODEL1310110040#
type: Reaction
name: N-acetylneuraminate transport into lysososme

http://identifiers.org/biomodels.db/MODEL1310110040#_df0c7c1c_0bd5_416e_a360_f97a1837b7eb
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: ST3GAL3
is encoded by: hsa:6487
has only substance units: false

metaM HC01399 m
initial concentration: 1.0
name: (S)-3-Hydroxytetradecanoyl-CoA
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:27466
has only substance units: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
type: Species
boundary condition: false

metaM pser L c
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: CHEBI:15811
boundary condition: false
is: HMDB01721
name: O-Phospho-L-serine
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR r2534
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
reversible: true

metaR r2386
product: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaR ASPTAm
name: aspartate transaminase
fast: false
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110040#

metaR APOCF
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
name: Apocarboxylase formation
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_def4fbbe_4c79_4591_8f27_0b2c5d1e1f21
is encoded by: hsa:1718
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: Q15392
name: DHCR24
initial concentration: NaN
has only substance units: false

metaR r1143
fast: false
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
reversible: false

metaM fe3 c
name: Fe3+
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB12943
notes: FORMULA: Fe CHARGE: 3
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaR ACACT6p
name: acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_db0bb15c_bc6a_4ed6_b06d_ecab869f8d30
is encoded by: hsa:60490
is: Q96CD2
name: PPCDC
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM 3mop m
has only substance units: false
initial amount: NaN
is: CHEBI:28654
type: Species
initial concentration: 1.0
constant: false
is: HMDB00491
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
name: 3-methyl-2-oxopentanoate
is: SBO:0000247

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
initial concentration: 1.0
is: HMDB01202
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57566
is: SBO:0000247
constant: false

metaR ABTti
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion

metaM coa x
constant: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
is: CHEBI:57287
initial concentration: 1.0
is: C00010
boundary condition: false
is: SBO:0000247
name: Coenzyme A
initial amount: NaN
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110040#_635fe169_81cc_4d9b_adb5_8a5aedf87914
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: SULT1A1
is encoded by: hsa:6817

metaR r1144
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
kinetic law: MODEL1310110040#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_838d8431_144a_4470_962f_7a9f1a7bfe72
boundary condition: true
initial amount: NaN
constant: false
is: Q9Y6M9
type: Species
is encoded by: hsa:4715
name: NDUFB9
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM cholp c
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: choline phosphate(1-)
is: CHEBI:295975
is: SBO:0000247
constant: false

metaM dhbpt c
type: Species
is: CHEBI:20680
is: SBO:0000247
has only substance units: false
is: HMDB00038
name: 6,7-dihydrobiopterin
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
initial amount: NaN

metaR CORE6GTg
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
fast: false
reversible: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_076f01a5_5de9_4432_9a85_8d96729b618f
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AI926493
name: _AI926493_1_c
initial concentration: NaN
is: SBO:0000252

metaR CYSGLYexR
reactant: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
name: L-cysteine/glycine reversible exchanger
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction

metaR NDP10ex
name: nucleoside-diphosphatase (IDP), extracellular
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#

metaM ethamp c
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00224
boundary condition: false
is: CHEBI:58190
name: ethamp[c]
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8196356a_838c_48e9_b81f_f9f7da78e6a8
is: SBO:0000252
is encoded by: hsa:29085
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PHPT1
constant: false
is: Q9P019
type: Species
initial amount: NaN

metaR MALSO3tm
product: MODEL1310110040#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269

metaR ASAH1
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: N-acylsphingosine amidohydrolase
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.1.23

metaM 3ddcrn c
constant: false
type: Species
boundary condition: false
name: 3-hydroxydodecanoylcarnitine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C19H37NO5 CHARGE: 0
is: HMDB03712
is: SBO:0000247
has only substance units: false

metaR GLCNACASE4ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_9eeff95d_b2eb_4f1c_8476_ad935d9cda50
initial amount: NaN
constant: false
initial concentration: NaN
is: Q99519
boundary condition: true
is encoded by: hsa:4758
name: NEU1
has only substance units: false
type: Species
is: SBO:0000252

metaR RAHY
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reversible: false
name: retinoic acid hydroxylation (P450)
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_ce9b7b35_f9f7_4638_97db_cdb39c23c92e
initial concentration: NaN
type: Species
is encoded by: hsa:498
boundary condition: true
name: ATP5A1
has only substance units: false
initial amount: NaN
is: A8K092
is: SBO:0000252
constant: false

metaR FBA
type: Reaction
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reactant: MODEL1310110040#
name: fructose-bisphosphate aldolase

metaM 35cgmp n
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: 3',5'-cyclic GMP(1-)
boundary condition: false
type: Species
is: HMDB01314
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
constant: false
is: CHEBI:57746
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9b072260_2ce9_496e_b91a_38efdb7cdb5d
boundary condition: true
has only substance units: false
name: SDHA
initial amount: NaN
constant: false
is: P31040
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6389

http://identifiers.org/biomodels.db/MODEL1310110040#_106ba257_b89d_41d4_8824_47a90c33c197
initial amount: NaN
has only substance units: false
has part: P24539
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: O75947
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:518
is encoded by: hsa:515
has part: P18859
is encoded by: hsa:522
constant: false
is encoded by: hsa:10476
boundary condition: true

metaR 3SPYRSPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reactant: MODEL1310110040#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110040#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110040#

metaR C181OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaR r1291
is: SBO:0000185
fast: false
reversible: true
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_c7cefe08_eb04_43a5_a203_a3b3cda55ed9
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: _AI440329_1_r
is encoded by: hsa:AI440329
initial amount: NaN
has only substance units: false

metaM nm2masn g
notes: FORMULA: C42H70N3O30X CHARGE: 0
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
is: C05884
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false

metaM q10h2 m
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
boundary condition: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
is: HMDB13111

metaM ebastineoh e
initial concentration: 1.0
is: HMDB01191
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:17625
notes: FORMULA: C32H39NO3 CHARGE: 0
name: hydroxylated ebastine
has only substance units: false
initial amount: NaN

metaR RE3244R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
name: RE3244
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176

metaM thcholstoic m
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB03873
constant: false
is: CHEBI:18402

metaM arachd x
is: HMDB01043
initial amount: NaN
constant: false
name: arachidonate
boundary condition: false
is: SBO:0000247
is: CHEBI:32395
type: Species
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
initial concentration: 1.0

metaR FAOXC161C161OHm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR DUDPtn
name: dUDP nuclear transport
kinetic law: MODEL1310110040#
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reactant: MODEL1310110040#
fast: false
is: SBO:0000185

metaM q10 m
is: HMDB01072
type: Species
initial amount: NaN
name: ubiquinone-10
constant: false
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
is: CHEBI:46245
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d00ffe9a_d06c_4ba0_a2dc_eb4de7918b07
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:9058
has only substance units: false
initial amount: NaN
name: SLC13A2
initial concentration: NaN
is: E7ETH5

metaR DOLPMT L
fast: false
reversible: false
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
name: Dolichyl-phosphate D-mannosyltransferase (liver)
type: Reaction
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.83
modifier: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR r0483
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110040#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000

metaR DLNLCGCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
reversible: false
type: Reaction
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#

metaR r1292
reversible: true
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_bfcb735f_1031_4e0a_bc22_83ee5e1cbeb1
boundary condition: true
type: Species
constant: false
is: P00450
name: CP
is encoded by: hsa:1356
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r1147
kinetic law: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_9966005f_eb2b_4edf_b482_4763b074f3b8
constant: false
is: SBO:0000252
is: Q86YI5
initial amount: NaN
name: DLAT
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1737

metaR EX 3ddcrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR TRPt
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269
name: L-tryptophan transport

metaR GT1Ate
kinetic law: MODEL1310110040#
is: SBO:0000185
name: gt1a hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3a9ce7df_b95a_4fd0_b05a_e23f2222de8c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4695
is: O43678
name: NDUFA2
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaM ksi pre36 g
has only substance units: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 36
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_ed89a705_f03b_4650_bd8c_c2d5442d997b
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:34
is: SBO:0000252
name: ACADM
boundary condition: true
is: P11310
has only substance units: false
initial amount: NaN

metaM ksi pre14 g
name: keratan sulfate I biosynthesis, precursor 14
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial amount: NaN
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM 3uib c
boundary condition: false
constant: false
initial concentration: 1.0
name: 3-Ureidoisobutyrate
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
type: Species
is: CHEBI:1670
is: HMDB02031
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR GLYPROPRO1c
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Prolylglycine in the small intestine for cellular uptake
type: Reaction

metaM ksi e
has only substance units: false
initial amount: NaN
is: CHEBI:17268
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
is: HMDB00211
name: keratan sulfate I
constant: false

metaM 3ivcrn e
constant: false
name: 3-hydroxy-isovaleryl carnitine
boundary condition: false
is: SBO:0000247
is: HMDB13336
has only substance units: false
type: Species
notes: FORMULA: C12H23NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaR DGSNt
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoyguanosine transport via diffusion
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_30aea053_a830_4e8a_a865_9f626c86dcd5
is encoded by: hsa:47
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: ACLY
is: P53396
is: SBO:0000252
initial amount: NaN

metaM triodthy c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00265
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: CHEBI:18258
type: Species

metaR GLCAASE1ly
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110040#

metaM vacccoa c
name: vaccenyl coenzyme A
is: http://identifiers.org/pubchem.compound/9543677
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_1413a7fd_b946_40a0_8b2e_a4316ca12483
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false
constant: false
initial amount: NaN

metaR r0450
is: SBO:0000176
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39

metaR DNDPt41m
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reversible: false
name: dUTP transport via dCDP antiport
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_113cc5c1_5324_4768_bb42_c6a4b466ae4f
name: ENTPD1
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q86VV3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:953

metaR GUAPRT
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
name: guanine phosphoribosyltransferase
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
is: SBO:0000176
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_7b131c49_c200_472e_a666_0b1cf745802a
initial amount: NaN
constant: false
is: P49327
is: SBO:0000252
type: Species
is encoded by: hsa:2194
boundary condition: true
name: FASN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_0dff4b10_6851_48c5_b5b3_b6d5ff5bf856
is: P11310
initial concentration: NaN
has only substance units: false
is encoded by: hsa:34
name: ACADM
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaM mescoa m
is: CHEBI:27969
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
is: C06028
constant: false
initial amount: NaN
name: Mesaconyl-CoA
has only substance units: false

metaR CYTDK2m
name: cytidine kinase (ATP), mitochondrial
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000

metaM cholcoa r
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
name: choloyl-CoA(4-)
initial concentration: 1.0
constant: false
is: CHEBI:57373

metaM ksi g
is: HMDB00189
is: CHEBI:57614
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
initial amount: NaN

metaR ACHtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is described by: ECO:0000000
product: MODEL1310110040#
reversible: true
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
name: Acetylcholin transport, nuclear trhough pores
fast: false

metaM ksi deg27 l
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 27
is: SBO:0000247
boundary condition: false
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
type: Species

metaR ACALDt
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
name: acetaldehyde reversible transport
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000

metaM ebastine r
type: Species
name: ebastine
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
initial concentration: 1.0
is: CHEBI:211060
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_41862dcd_4a9a_44dd_b583_78aae25d9fca
constant: false
has only substance units: false
name: PPA1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5464
initial amount: NaN
is: Q15181
initial concentration: NaN
type: Species

metaM ksi deg9 l
is: SBO:0000247
boundary condition: false
name: keratan sulfate I, degradation product 9
initial concentration: 1.0
type: Species
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_71fcad13_eb5b_4f71_a3f6_66dbc260b2e1
initial concentration: NaN
name: GAD1
is encoded by: hsa:2571
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q8IVA8
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a772cc4c_78d3_4824_8614_131557ea84fa
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: _AI345944_1_m
is encoded by: hsa:AI345944
has only substance units: false
initial amount: NaN
type: Species

metaR r2379
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM cspg a l
initial amount: NaN
is: HMDB02183
type: Species
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
is: SBO:0000247
is: CHEBI:36005
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_cd8001cc_e9e3_4f3a_b4ce_725023260c29
is encoded by: hsa:57030
constant: false
boundary condition: true
initial concentration: NaN
is: Q9P2U7
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC17A7
has only substance units: false

metaM ptth m
boundary condition: false
is: HMDB03426
is: CHEBI:16753
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
type: Species
initial amount: NaN
name: pantetheine

metaR r0517
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false

metaM acac m
is: SBO:0000247
is: CHEBI:13705
type: Species
boundary condition: false
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
initial concentration: 1.0
name: acetoacetate
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9ad72071_978b_4710_bc5a_937b5078eef6
name: SLC35A1
initial concentration: NaN
is: P78382
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:10559
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_c2742f98_4bc5_4c89_b476_dda485778afb
boundary condition: true
is encoded by: hsa:10568
initial amount: NaN
is: O95436
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: SLC34A2
is: SBO:0000252

metaR RE3346M
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110040#
name: RE3346
reversible: true
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1bfa1702_1f4c_41eb_adb3_c17aa3701448
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is: P22413
boundary condition: true
is encoded by: hsa:5167
has only substance units: false
name: ENPP1
constant: false

metaR FAOXC18480m
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110040#
is described by: ECO:0000000
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110040#

metaR PTDCACRNt
reversible: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: pentadecanoate transport into the mitochondria
kinetic law: MODEL1310110040#
fast: false
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#

metaR r2376
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
product: MODEL1310110040#
reversible: true
type: Reaction
reactant: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_bdc7450c_67e8_4775_b115_ef5050fa6a60
is encoded by: hsa:1962
is: Q9NY65
type: Species
name: EHHADH
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM btamp m
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB04220
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
type: Species
is: CHEBI:3110
constant: false
name: Biotinyl-5'-AMP

http://identifiers.org/biomodels.db/MODEL1310110040#_4d462f86_efed_4744_94d2_7d964bfda77e
has only substance units: false
is: SBO:0000252
is: P48735
initial concentration: NaN
type: Species
name: IDH2
boundary condition: true
initial amount: NaN
is encoded by: hsa:3418
constant: false

metaM eicostet c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36033
name: eicosatetranoic acid
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
constant: false
is: HMDB02177

metaR r2377
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110040#_20b8304e_ac9c_4384_a2aa_1f2af503b193
is: Q4J699
initial amount: NaN
type: Species
constant: false
name: ATP2B2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:491

metaM ttdcrn c
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
name: tetradecanoyl carnitine
is: HMDB05066
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3413344
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaR CRNt
is: SBO:0000185
modifier: MODEL1310110040#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110040#
name: L-carnitine reversible transport
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0333c7f5_1187_45cd_a760_be42c82a94b1
initial concentration: NaN
is: P25705
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ATP5A1
is encoded by: hsa:498
constant: false
type: Species
boundary condition: true

metaR C100CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaM ocdca c
initial concentration: 1.0
has only substance units: false
is: CHEBI:25629
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00827
is: SBO:0000247
name: stearate
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_39cf68a5_f935_439b_98f0_16d3db6f106f
boundary condition: true
name: NME1
constant: false
is encoded by: hsa:4830
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: P15531

metaM glyb c
boundary condition: false
initial amount: NaN
name: glycine betaine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
is: HMDB00043
initial concentration: 1.0
constant: false
is: CHEBI:17750

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_2407cbdd_12de_404d_b23f_e80595e08330
initial amount: NaN
is: SBO:0000252
is: Q9H008
name: LHPP
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:64077
has only substance units: false
type: Species

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#

metaM L2aadp6sa m
constant: false
initial amount: NaN
is: CHEBI:17917
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
is: HMDB01263
boundary condition: false
name: L-allysine

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR r2374
reversible: true
product: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000

metaR r2375
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_0d5ee245_7442_43c3_8bd5_67b178906753
boundary condition: true
name: NDUFV2
is: SBO:0000252
initial amount: NaN
is: P19404
constant: false
initial concentration: NaN
is encoded by: hsa:4729
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_361ff4e8_8dd8_49fd_be16_e86163456dda
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFC1
initial concentration: NaN
constant: false
is: O43677
is encoded by: hsa:4717

metaM 3hddcoa m
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: HMDB02014
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_fd25a985_3366_4b7f_bb1f_d9a083a31478
constant: false
name: HEXB
initial amount: NaN
is: P07686
is encoded by: hsa:3074
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM c4crn m
type: Species
is: HMDB02013
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
constant: false
is: C02862

metaM xylu L c
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: L-xylulose
is: HMDB00751
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
is: CHEBI:17399
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_c8733a6e_37a4_4d94_a7ff_1c70813ed7c1
initial amount: NaN
name: MTMR6
constant: false
is: SBO:0000252
type: Species
is: Q9Y217
initial concentration: NaN
is encoded by: hsa:9107
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_af60176c_59b6_4c89_a9ae_fa508975d9e1
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: ATP5J
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:522

metaM ocdca e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:25629
has only substance units: false
constant: false
boundary condition: false
is: HMDB00827
is: SBO:0000247
name: octadecanoate (n-C18:0)
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
type: Species

metaR RE2541E
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
name: RE2541
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_96896440_fb20_4f2b_8809_c08bfb2c9260
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: CHKB
is: Q9Y259
is encoded by: hsa:1120

metaR C161CPT12
reactant: MODEL1310110040#
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
reversible: false

metaR r2372
is: SBO:0000185
kinetic law: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_038357fb_e7ba_4b16_93a7_4162318d1aca
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2530
initial amount: NaN
name: FUT8
is: A8K8P8
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM hs deg1 l
is: SBO:0000247
has only substance units: false
name: heparan sulfate, degradation product 1
initial concentration: 1.0
is: HMDB06254
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C79H115N5O99S11 CHARGE: -12

metaR LACZe
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.108
name: b-galactosidase, extracellular
reversible: false

metaM cholcoa x
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
is: HMDB01374
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57373
type: Species
name: choloyl-CoA(4-)

metaR DDPGAm
reversible: true
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is described by: ECO:0000000

metaM fe2 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Fe2+
is: CHEBI:29033
is: HMDB00692
type: Species
is: C00023
constant: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

metaR NADH2 u10m
name: NADH dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
reversible: false
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/1.6.99.3

metaM dttp c
initial amount: NaN
is: C00459
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP
is: HMDB01342
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:37568

http://identifiers.org/biomodels.db/MODEL1310110040#_921d17cb_31e0_4c9c_901b_11dcb0c2e407
is: Q9NP59
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC40A1
is encoded by: hsa:30061

metaR r1600
kinetic law: MODEL1310110040#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR S6T8g
modifier: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110040#
reversible: false
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM HC00342 m
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16383
name: cis-aconitate(3-)
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
boundary condition: false

metaM hxcoa x
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB00705
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Hexanoyl-CoA (n-C6:0CoA)

metaR TSTSTERONEtr
is: SBO:0000185
fast: false
reactant: MODEL1310110040#
reversible: true
name: testosterone intracellular transport
is described by: ECO:0000000
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM glyb e
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: glycine betaine
is: SBO:0000247
is: CHEBI:17750
is: HMDB00043
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9b058786_7303_4c45_898d_e5668c60606a
name: PDE6B
is: B7Z9T9
is encoded by: hsa:5158
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_77b47795_6845_4801_9c69_e8317dc21305
constant: false
initial amount: NaN
is: Q9NY65
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1962
name: EHHADH
has only substance units: false
type: Species
boundary condition: true

metaR EICOSTETt
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: fatty acid transport via diffusion

metaR r2373
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110040#
is: SBO:0000185
type: Reaction

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM ksi l
has only substance units: false
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
is: HMDB01354
is: SBO:0000247
boundary condition: false
name: keratan sulfate I
type: Species
is: C00445
initial concentration: 1.0
is: CHEBI:57455

metaR PYRt2m
is described by: ECO:0000000
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
name: pyruvate mitochondrial transport via proton symport
modifier: MODEL1310110040#
fast: false
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is: SBO:0000185

metaM pyam5p c
constant: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58451
type: Species
boundary condition: false
is: HMDB01555
name: Pyridoxamine 5'-phosphate
is: SBO:0000247
is: C00647
has only substance units: false

metaM 2mbcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
name: 2-methylbutanoyl-CoA(4-)
constant: false
is: SBO:0000247
is: CHEBI:57336
has only substance units: false
is: HMDB01041
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_54704340_e8f7_4cf0_85d2_ce3448b0b8eb
has only substance units: false
is encoded by: hsa:1798
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DPAGT1
constant: false

metaM ksi pre22 g
name: keratan sulfate I biosynthesis, precursor 22
is: CHEBI:58053
boundary condition: false
initial amount: NaN
is: HMDB00175
type: Species
initial concentration: 1.0
is: C00130
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C185H297N13O150S6X CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110040#_1b513c56_961f_42b2_aa7e_92662d20646b
has only substance units: false
is encoded by: hsa:115111
constant: false
is: SBO:0000252
type: Species
name: SLC26A7
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1ccde978_0e4d_4643_b799_31ffe7ac857c
is encoded by: hsa:2645
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q53Y25
is: SBO:0000252
constant: false
has only substance units: false
name: GCK
type: Species

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR GLCNACASE5ly
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_5c4c79d9_2555_46b5_a6e7_b98a223ad9ec
is encoded by: hsa:1349
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: COX7B
is: P24311
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM dttp e
has only substance units: false
is: HMDB01342
name: dTTP(4-)
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:37568
is: SBO:0000247

metaM cdpchol c
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01413
type: Species
name: CDPcholine
initial amount: NaN
is: CHEBI:16436
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_61192a26_424c_4d8f_8afb_36ecc95687a3
is encoded by: hsa:3658
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: IREB2
type: Species
initial amount: NaN
is: P48200
has only substance units: false

metaR r0669
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR CDIPTr
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.8.11
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110040#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: phosphatidylinositol synthase (Homo sapiens)

http://identifiers.org/biomodels.db/MODEL1310110040#_da2f00d9_2581_40f8_9cdf_b27071db477c
is encoded by: hsa:30
name: ACAA1
constant: false
is: SBO:0000252
type: Species
is: Q96CA6
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM dcacoa x
is: C05274
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
is: CHEBI:61430
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
is: HMDB06404

http://identifiers.org/biomodels.db/MODEL1310110040#_3fe3f0b1_bae1_48f9_b2cf_593b57f5c448
has only substance units: false
initial amount: NaN
boundary condition: true
is: P35790
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1119
constant: false
name: CHKA

metaR SERGLNexR
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#
type: Reaction
name: L-Serine/Glutamine reversible exchange
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_89e74680_55db_43f5_aae4_4fd607bd6f6b
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6547
name: SLC8A3
constant: false
boundary condition: true
has only substance units: false

metaM atp x
is: CHEBI:57299
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00538
is: C00002
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: ATP(4-)

metaR ALCD21 D
kinetic law: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
reactant: MODEL1310110040#
name: alcohol dehydrogenase (D-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction

metaM c101coa c
name: decenoylcoa
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
is: HMDB00651
is: SBO:0000247
has only substance units: false

metaM tym c
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
has only substance units: false
is: HMDB00306
boundary condition: false
is: CHEBI:327995
name: tyraminium
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR HTDCACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_2874bb5d_75fc_4a1b_afcf_89d3223c2cb2
name: SLC27A5
is: Q9Y2P5
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:10998
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r2371
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaR r0456
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110040#
type: Reaction
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113

metaM cs e deg4 l
initial amount: NaN
is: HMDB00127
is: SBO:0000247
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
constant: false
is: CHEBI:15748
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H46NO38S4 CHARGE: -5
has only substance units: false

metaM hpdca e
initial concentration: 1.0
is: CHEBI:32366
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
name: margarate
type: Species
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259

metaR DTDPtn
name: dTDP nuclear transport
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110040#
fast: false
reversible: true

metaR r0224
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false

metaM acac e
is: CHEBI:13705
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: acetoacetate
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060

metaM succ x
name: Succinate
initial amount: NaN
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
constant: false
is: HMDB00254
initial concentration: 1.0
boundary condition: false
is: C00042
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7feec10e_67a8_4c89_bc47_8a8d0cc22710
constant: false
is encoded by: hsa:3295
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: E9PB82
name: HSD17B4
initial amount: NaN

metaR r0119
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false
is: SBO:0000176
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction

metaR TYRt
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR PYRt2p
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000269
type: Reaction
name: pyruvate peroxisomal transport via proton symport
product: MODEL1310110040#

metaM aicar c
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: HMDB01517
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
boundary condition: false
is: CHEBI:58475
initial concentration: 1.0
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677

metaR LEUPHELAT2tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_4d34dcf8_f8fe_4f55_bc2e_4c126db96982
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4830
name: NME1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM HC01104 e
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
boundary condition: false
is: SBO:0000247
constant: false

metaR EX gt1a hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GT1a (homo sapiens) exchange
type: Reaction

metaM ksii core4 pre6 g
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: CHEBI:28067
type: Species
is: SBO:0000247

metaR GLNtm
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reactant: MODEL1310110040#
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#

metaR ALASm
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110040#
reversible: false
fast: false
name: 5-aminolevulinate synthase
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.37
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.29
product: MODEL1310110040#

metaM cspg a e
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
is: CHEBI:16040
has only substance units: false
initial concentration: 1.0
is: HMDB00630

metaR GLYt4
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
name: glycine transport via sodium symport
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
reversible: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#

metaM ddcacoa m
initial amount: NaN
is: CHEBI:57375
initial concentration: 1.0
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
is: HMDB03571
constant: false
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_c7ee8f9b_9eea_435e_ae4e_1697258fc78a
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5149
initial concentration: NaN
name: PDE6H
boundary condition: true
is: Q13956
constant: false
type: Species

metaR OCTDECCPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR S4TASE5ly
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false

metaM spc hs c
name: sphingosylphosphorylcholine
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5311445
type: Species
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR 3AIBtm
fast: false
kinetic law: MODEL1310110040#
name: 3-amino-isobutyrate transport, mitochondrial
reversible: false
product: MODEL1310110040#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_efc6878c_4b88_4a98_95bd_7b2d9c63eec7
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:514
type: Species
name: ATP5E
boundary condition: true
is: SBO:0000252

metaM 1pipdn2c x
has only substance units: false
initial amount: NaN
boundary condition: false
name: 1-piperideine-2-carboxylate
type: Species
is: HMDB01084
is: CHEBI:16187
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092

metaM hpdca c
has only substance units: false
name: margarate
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: SBO:0000247
is: CHEBI:32366
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB02259
boundary condition: false

metaR OCDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110040#
name: fatty acid transport via diffusion
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#

metaM hs deg12 l
has only substance units: false
is: HMDB06254
is: SBO:0000247
type: Species
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
name: heparan sulfate, degradation product 12

metaM fe2 e
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
is: CHEBI:29033
initial concentration: 1.0
is: C00023
is: HMDB00692
name: Fe2+
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
initial amount: NaN

metaR OCTDECCPT2
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM aicar e
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial amount: NaN
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
is: HMDB01517
boundary condition: false
is: C04677
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_1e9bfc09_0fa7_4524_b72a_8ec3a7e3a6c3
is encoded by: hsa:3295
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: E9PB82
boundary condition: true
name: HSD17B4
is: SBO:0000252

metaM ebastine e
is: CHEBI:211060
initial concentration: 1.0
type: Species
name: ebastine
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_1c97b45c_d194_4183_b067_f61e1504d2ea
name: _100128062_1_m
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:100128062
type: Species
boundary condition: true
has only substance units: false

metaR RE0452M
type: Reaction
product: MODEL1310110040#
reversible: true
is: SBO:0000176
name: RE0452
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:

metaR ILEt5m
fast: false
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
name: Isoleucine mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110040#_9833a4bd_ff1d_4194_85cf_f74638526607
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:22934
name: RPIA
is: SBO:0000252
is: P49247
boundary condition: true
has only substance units: false
initial amount: NaN

metaR FADH2ETC
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000134
reversible: false
product: MODEL1310110040#
fast: false
name: Complex II reaction for respiratory chain

metaM 2mop c
initial amount: NaN
has only substance units: false
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
constant: false
is: HMDB01172
initial concentration: 1.0
boundary condition: false
type: Species

metaM glyb m
boundary condition: false
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
constant: false
is: CHEBI:17750
initial concentration: 1.0
name: glycine betaine
is: HMDB00043
is: SBO:0000247
initial amount: NaN

metaR GULN3D
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110040#
name: L-gulonate 3-dehydrogenase
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction

metaR VACCCRNt
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
is: SBO:0000185

metaM ttdcrn m
has only substance units: false
initial amount: NaN
name: tetradecanoyl carnitine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3413344
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB05066

http://identifiers.org/biomodels.db/MODEL1310110040#_2410500a_3dcf_4493_a2e4_ecef1cfbb606
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:D87002
initial amount: NaN
name: _D87002_1_e
initial concentration: NaN

metaM spc hs e
is: http://identifiers.org/pubchem.compound/5311445
type: Species
name: sphingosylphosphorylcholine
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false

metaR RE1534M
is: SBO:0000176
name: RE1534
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM triodthy e
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
initial concentration: 1.0

metaR DHCHOLESTANATEtm
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000185
type: Reaction
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_1b1d8dd9_9b8f_4aaa_8f0a_7afd77acb95a
name: ALDOB
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: P05062
is encoded by: hsa:229
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR RIBt
product: MODEL1310110040#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
name: ribose transport via diffusion
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR ARACHDCOAtx
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reversible: true
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110040#_c477e4a3_9dfa_4744_8638_6e343e938bd5
initial amount: NaN
boundary condition: true
is: SBO:0000297
constant: false
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
initial concentration: NaN
has only substance units: false
type: Species

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
is: CHEBI:59458
has only substance units: false
constant: false
is: C04352
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01117
boundary condition: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

http://identifiers.org/biomodels.db/MODEL1310110040#_c6c5faff_a40a_44e1_bb84_6526148ccae3
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: LHPP
initial amount: NaN
is encoded by: hsa:64077
has only substance units: false
is: Q9H008

metaR HISt4
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000269
name: L-histidine transport in via sodium symport
reversible: false
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11254.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10930503 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110040#_aa289a1e_404c_45c7_bdf1_c1aefff611b0
name: PDE9A
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM gp1calpha hs e
name: GP1c alpha
initial concentration: 1.0
is: HMDB01397
is: CHEBI:58115
type: Species
constant: false
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM c4crn x
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: butyryl carnitine
is: SBO:0000247
is: C02862
is: HMDB02013
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM ksii core2 pre9 g
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 9
is: CHEBI:28067
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C75H120N6O59S2X CHARGE: -3

metaM cs a deg4 l
constant: false
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2
has only substance units: false
is: SBO:0000247
is: HMDB01354
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
boundary condition: false
is: CHEBI:57455
initial amount: NaN

metaM retinol cis 11 c
is: CHEBI:16302
initial amount: NaN
has only substance units: false
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
boundary condition: false
name: 11-cis-retinol
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR RE0453N
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
name: RE0453
reversible: true
reactant: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_1929a884_7dfd_46e7_a56e_e24cb9aee743
is: SBO:0000252
type: Species
name: HADHA
is encoded by: hsa:3030
has only substance units: false
is: E9KL44
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM HC01405 m
name: (S)-Hydroxyoctanoyl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:28632
constant: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
is: SBO:0000247

metaM atp m
is: SBO:0000247
has only substance units: false
type: Species
name: ATP(4-)
is: HMDB00538
constant: false
is: C00002
is: CHEBI:57299
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_275b9768_97f6_4b8b_9373_5609dd26b6e0
constant: false
type: Species
is: SBO:0000252
is: Q9BUM1
boundary condition: true
is encoded by: hsa:92579
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: G6PC3

metaR RETFAt
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: false
type: Reaction
fast: false
name: fatty acid retinol efflux

http://identifiers.org/biomodels.db/MODEL1310110040#_2d993e78_8f7c_4dc1_90a9_bf5aa33d1bc4
has only substance units: false
type: Species
boundary condition: true
is: B4DK61
name: ACOX1
is encoded by: hsa:51
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_dcdc4719_5085_4ec2_8266_bd7fba854521
initial amount: NaN
is encoded by: hsa:5140
boundary condition: true
type: Species
name: PDE3B
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q13370

http://identifiers.org/biomodels.db/MODEL1310110040#_94da0285_2fc0_4966_8c30_f44a83a26083
is: Q9UHI5
has only substance units: false
name: SLC7A8
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:23428

metaR NTD11
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
fast: false
name: 5'-nucleotidase (IMP)
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110040#

metaR 3SALACBOXL
modifier: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.29
type: Reaction
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
name: 3-Sulfino-L-alanine carboxy-lyase
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.1.1.15

metaR CLOXAtex2
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: chloride transport via oxalate countertransport (2:1)
type: Reaction
is described by: ECO:0000304

metaR GLNLASEer
product: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
kinetic law: MODEL1310110040#
is described by: ECO:0000000
name: gluconolactonase, endoplasmic reticulum
reactant: MODEL1310110040#
reversible: true
fast: false
type: Reaction

metaM ebastine c
is: CHEBI:211060
name: ebastine
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C32H39NO2 CHARGE: 0 INCHI: InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM m4mpdol L c
is: CHEBI:37633
has only substance units: false
type: Species
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_aa137388_e262_4612_98d8_dd58ebef24ab
boundary condition: true
is: Q9UHW9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9990
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: SLC12A6

metaR RE0453M
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
name: RE0453
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110040#

metaR RE1448N
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
fast: false
is described by: ECO:0000000
name: RE1448
is: SBO:0000176
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaM atp n
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: CHEBI:57299
has only substance units: false
type: Species
name: ATP(3-)
initial concentration: 1.0
is: HMDB00538
constant: false
boundary condition: false

metaM L2aadp6sa c
is: SBO:0000247
constant: false
is: HMDB01263
initial amount: NaN
is: CHEBI:17917
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
name: L-allysine
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaR UGT1A10r
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is described by: ECO:0000134
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_a3eb9807_e01b_40f4_bf58_eb4b8720e3d7
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:55907
name: CMAS
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q8NFW8

metaM HC01459 x
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:27458
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450

metaM ddeccrn e
is: SBO:0000247
constant: false
notes: FORMULA: C19H37NO4 CHARGE: 0
name: lauroyl carnitine
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB02250
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_3b6f3db2_8d49_4aaa_9e32_a749063d3cbd
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10195
is: SBO:0000252
name: ALG3
constant: false
is: Q92685
type: Species
initial concentration: NaN

metaM rbt c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15963
name: D-ribitol
constant: false
boundary condition: false
type: Species
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
is: SBO:0000247

metaM gp1calpha hs g
name: GP1c alpha
is: CHEBI:3513
initial concentration: 1.0
type: Species
constant: false
is: C00213
is: SBO:0000247
is: HMDB00271
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_10c4c7e8_0870_434d_938d_7716705e2f38
initial concentration: NaN
is encoded by: hsa:5152
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: PDE9A
is: SBO:0000252
type: Species

metaR CITt4 4
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
is described by: ECO:0000006
modifier: MODEL1310110040#
name: citrate transport via sodium symport
type: Reaction

metaR r0870
fast: false
kinetic law: MODEL1310110040#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.7.72
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.4

http://identifiers.org/biomodels.db/MODEL1310110040#_ca81256d_20ac_471a_994a_c47addf1a958
is encoded by: hsa:160851
has only substance units: false
boundary condition: true
name: DGKH
initial concentration: NaN
constant: false
type: Species
is: Q86XP1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b985b1ee_4404_4f74_a7e4_34d387ef7233
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
name: SLC26A6
boundary condition: true
is encoded by: hsa:65010
is: Q9NQU1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_6f8e69a9_f6a8_4657_abb4_cd76a75c7ff8
is encoded by: hsa:1109
is: SBO:0000252
type: Species
constant: false
name: AKR1C4
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P17516

metaR SARCStex
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
name: Sarcosine transport (extracellular to cytosol)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: false
fast: false
is described by: ECO:0000000

metaM HC00342 c
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
initial concentration: 1.0
is: CHEBI:16383
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: cis-aconitate(3-)

http://identifiers.org/biomodels.db/MODEL1310110040#_45baac34_6c6b_47d1_bbe9_3c311186379f
name: ACSL3
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: O95573
is encoded by: hsa:2181
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9eab37e0_cad7_4852_a648_4340acb9d1ed
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NQ66
initial concentration: NaN
is encoded by: hsa:23236
name: PLCB1
constant: false
boundary condition: true

metaM btamp c
is: CHEBI:3110
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Biotinyl-5'-AMP
type: Species

metaM c226crn m
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/127055
type: Species
name: cervonyl carnitine
is: HMDB06510
is: SBO:0000247

metaM ddeccrn c
boundary condition: false
is: HMDB02250
name: lauroyl carnitine
is: SBO:0000247
notes: FORMULA: C19H37NO4 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN

metaR NRPPHRtu
name: Norepinephrine uniport
fast: false
is described by: ECO:0000269
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
kinetic law: MODEL1310110040#
is: SBO:0000185

metaR PCm
name: pyruvate carboxylase
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/6.4.1.1
modifier: MODEL1310110040#
is: SBO:0000176

metaR CITL
name: Citrate lyase
fast: false
reactant: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_8e9c8335_f0d2_4a63_8e2f_3504f965b5a1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2879
boundary condition: true
type: Species
is: SBO:0000252
is: P36969
has only substance units: false
constant: false
name: GPX4

http://identifiers.org/biomodels.db/MODEL1310110040#_60e9b177_67fa_4709_a87f_4dd28e5f0060
is encoded by: hsa:1841
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: P23919
name: DTYMK
has only substance units: false
constant: false
initial amount: NaN

metaR CHSTEROLt1
name: cholesterol intracellular transport
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
product: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is described by: ECO:0000304
reactant: MODEL1310110040#

metaR GARFT
kinetic law: MODEL1310110040#
name: phosphoribosylglycinamide formyltransferase
fast: false
modifier: MODEL1310110040#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
type: Reaction
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_ae6f3293_a4fe_4817_bd1d_4d93077d90e3
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5151
is: O60658
boundary condition: true
initial amount: NaN
name: PDE8A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_7463d0d2_8cf0_403e_9bae_0d6eda588229
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: NNT
is: SBO:0000252
is encoded by: hsa:23530

metaM dcacoa m
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
constant: false
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06404
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_59aaa3e1_1615_4adb_91dd_6cb1a486a9a0
is: SBO:0000252
type: Species
is encoded by: hsa:84890
name: ADO
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: B3KXN9
boundary condition: true

metaR GLYOX
is: SBO:0000176
product: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.6
reversible: false
reactant: MODEL1310110040#
name: hydroxyacylglutathione hydrolase
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
kinetic law: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
is described by: ECO:0000269

metaR Htx
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: true
name: H transporter, peroxisome
type: Reaction

metaM omhpal r
initial amount: NaN
name: w-hydroxypalmiticacid
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false
initial concentration: 1.0
is: HMDB06294

http://identifiers.org/biomodels.db/MODEL1310110040#_ce5873c6_c502_445f_b1c1_eeff13be2912
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ALPL
is encoded by: hsa:249
is: SBO:0000252
is: B7Z4Y6
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7f47a905_d046_48e4_98a1_3ef1fc22540f
name: FLAD1
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:80308
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaM 3snpyr m
initial concentration: 1.0
has only substance units: false
is: HMDB02332
is: CHEBI:1665
name: 3-Sulfinopyruvate
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527

metaM succ c
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
name: Succinate
initial concentration: 1.0
boundary condition: false
type: Species
is: C00042
constant: false
has only substance units: false
is: HMDB00254
is: CHEBI:30031
is: SBO:0000247

metaR r0871
reversible: true
name: Diffusion
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110040#

metaR RE2625C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
name: RE2625
reactant: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR r0679
product: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110040#
is: SBO:0000176
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM atp r
is: HMDB00538
has only substance units: false
name: ATP(4-)
is: C00002
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57299
initial concentration: 1.0
constant: false

metaR RE2998M
name: RE2998
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#

metaR TMNDNCt
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true

metaR FAOXC183806m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reversible: false

metaM asn L m
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
is: SBO:0000247
constant: false
is: CHEBI:17196
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00168
boundary condition: false
initial concentration: 1.0

metaR C9BRxtc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaR RE1342C
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
name: RE1342

metaR PItg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000185

metaR CHSTEROLt3
fast: false
name: cholesterol intracellular transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_56f84b57_ab66_47aa_a530_56ba2a2951c3
is: SBO:0000252
type: Species
has only substance units: false
name: ACP2
initial amount: NaN
is encoded by: hsa:53
initial concentration: NaN
is: E9PCI1
constant: false
boundary condition: true

metaR r0002
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
name: Active transport
type: Reaction
reversible: true

metaM g3m8mpdol L r
type: Species
initial amount: NaN
is: C00459
is: HMDB01342
is: CHEBI:37568
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
boundary condition: false
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR GGH 7DHFl
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
product: MODEL1310110040#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR GTHDH
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reversible: false
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#

metaR r1811
is: SBO:0000185
type: Reaction
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Y+LAT2 Utilized transport
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM gp1calpha hs c
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:3513
is: C00213
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
name: GP1c alpha
initial amount: NaN
is: HMDB00271

http://identifiers.org/biomodels.db/MODEL1310110040#_e20e125c_895e_4ea9_b630_3b0f4cec0391
is encoded by: hsa:AI373818
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AI373818_1_m
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_8de1c71f_ffa8_4dcd_8e0a_62a713fb13bb
is encoded by: hsa:8760
type: Species
is: O95674
constant: false
initial amount: NaN
boundary condition: true
name: CDS2
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_8606f165_3bf2_4cfc_985a_eb3faf8530f7
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:112
name: ADCY6

metaR CHSTEROLt2
name: cholesterol intracellular transport
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110040#

metaM pap g
is: HMDB00061
type: Species
is: CHEBI:58343
is: SBO:0000247
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR GGH 7THFe
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_3d6992ab_f25a_4415_b196_9c51f3ba7885
initial amount: NaN
is: SBO:0000252
name: NDUFB6
has only substance units: false
type: Species
is encoded by: hsa:4712
is: Q5VYT2
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_fabc7a65_6d72_41e0_b849_d452ec028af7
name: _AI697028_1_e
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI697028
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR N3Tg
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.122
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
product: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#

metaM succ e
type: Species
constant: false
is: HMDB00254
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: succinate(2-)

metaR r0523
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110040#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
reversible: false

metaM Ssq23epx r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: (S)-2,3-epoxysqualene
is: CHEBI:15441
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: HMDB01188
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaR NACHEX12ly
fast: false
reactant: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110040#

metaR 3HCO3 NAt
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is: SBO:0000185
name: 3HCO3_NAt
reversible: true
kinetic law: MODEL1310110040#
is described by: ECO:0000134
reactant: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_32ce96d3_7eb4_4292_aad1_e00173527f1e
name: SLC25A5
type: Species
boundary condition: true
constant: false
is encoded by: hsa:292
initial concentration: NaN
is: Q6NVC0
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR G14T8g
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110040#
fast: false

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM 4ppcys m
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01117
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: CHEBI:59458
boundary condition: false

metaR r0522
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaM cholcoaone x
is: HMDB06891
has only substance units: false
initial amount: NaN
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial concentration: 1.0
is: CHEBI:58507
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_132bb39e_e8f8_4635_8e24_d1191de8cecb
has only substance units: false
boundary condition: true
is: Q05C14
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: FOLR3
is encoded by: hsa:2352

metaR CYSGLTH
product: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
fast: false
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM

metaM 13dpg c
constant: false
is: http://identifiers.org/pubchem.compound/3535
boundary condition: false
name: 3-Phospho-D-glyceroyl phosphate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57604
has only substance units: false
type: Species
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: C00236
is: HMDB01270
initial amount: NaN

metaR LYSOXp
name: L-lysine oxidase, peroxisomal
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_f9c6356c_95d6_41f6_a1dd_09561f922667
initial amount: NaN
is: Q02318
boundary condition: true
name: CYP27A1
has only substance units: false
is encoded by: hsa:1593
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM atp e
initial amount: NaN
type: Species
is: CHEBI:57299
initial concentration: 1.0
is: SBO:0000247
constant: false
name: ATP(4-)
is: C00002
has only substance units: false
boundary condition: false
is: HMDB00538

metaR BILDGLCURt
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110040#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
reversible: true

metaR GLCt1r
name: glucose transport (uniport)
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
modifier: MODEL1310110040#
product: MODEL1310110040#

metaR S6T10g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_ab6cf04a_4312_4590_9e7f_4f836fa51302
constant: false
name: PDE10A
is: Q9Y233
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10846
type: Species

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
reactant: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110040#
is described by: ECO:0000000
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5aeb5f5b_ad64_485b_9688_d1550727f0b2
is: SBO:0000252
constant: false
is: P43004
type: Species
is encoded by: hsa:6506
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC1A2

metaM pap c
type: Species
is: CHEBI:58343
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
is: HMDB00061
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
initial concentration: 1.0

metaR r1968
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction

metaR HYXNt
reactant: MODEL1310110040#
reversible: true
is: SBO:0000185
modifier: MODEL1310110040#
name: Hypoxanthine transport
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is described by: ECO:0000269
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#

metaR M8MASNterg
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
is described by: ECO:0000000
name: m8masn transport from ER to Golgi apparatus
product: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
fast: false

metaM HC01118 r
initial amount: NaN
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57310
name: presqualene diphosphate(3-)
type: Species
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaM eicostet e
notes: FORMULA: C20H31O2 CHARGE: -1
is: SBO:0000247
name: eicosatetranoic acid
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02177
type: Species
is: CHEBI:36033
has only substance units: false

metaR MANtg
name: mannose efflux from Golgi apparatus
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_22a633b9_36c5_4f39_bcc8_9c2be45b0a15
is: Q8NEM3
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: SLC16A7
constant: false
is encoded by: hsa:9194

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaR SPH1Pte
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: sph1p transport
reversible: true
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_a7652486_644c_49dc_ad06_edc1491397db
name: PFKP
is: Q5VSR7
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5214

metaR TALA
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
name: transaldolase
product: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b316e2fd_346a_4ef4_a6a2_2885269f8ec2
has only substance units: false
is: O00754
type: Species
name: MAN2B1
is encoded by: hsa:4125
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaM 4h2oglt m
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:17742
has only substance units: false
constant: false
name: 4-hydroxy-2-oxoglutarate(2-)
is: HMDB02070
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2

metaM asn L c
is: CHEBI:17196
name: L-asparagine
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00168
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
initial amount: NaN

metaM acmanap c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
constant: false
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
is: CHEBI:58557
type: Species
is: HMDB01121
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_2114b24a_6e92_43ad_9117_e3ff60e08ec0
has only substance units: false
name: SYNJ1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8867
initial concentration: NaN
type: Species
is: O43426
constant: false
initial amount: NaN

metaR RE0453C
product: MODEL1310110040#
is described by: ECO:0000000
name: RE0453
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_6800c270_bbe5_44cb_8b15_ef6382cbc541
is: SBO:0000252
is: Q01415
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2585
boundary condition: true
name: GALK2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_1009baab_78d9_48dc_88eb_b73be84baaf5
is: P50053
name: KHK
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:3795

metaM ddcacoa c
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
constant: false
is: HMDB03571
is: C01832
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b478ab3c_f168_4735_81a8_0a6667895e5b
type: Species
is: P30049
name: ATP5D
is encoded by: hsa:513
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_95520ca6_1e03_404e_92dc_b226f727ad35
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
initial concentration: NaN
has part: P56134
initial amount: NaN
constant: false
is encoded by: hsa:9551
type: Species
is: SBO:0000297
is encoded by: hsa:522
has only substance units: false

metaR r0672
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
fast: false

metaM rbt e
name: D-ribitol
constant: false
type: Species
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15963
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_2f59a1af_6daf_4d54_b12d_8d1b73c7d1f2
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
name: PNP
initial amount: NaN
is: P00491
has only substance units: false
type: Species
is encoded by: hsa:4860

metaM 3hddcoa c
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
is: HMDB03712
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR FACOAL205
name: fatty-acid--CoA ligase
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110040#
reversible: true

metaR CHLtm
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
product: MODEL1310110040#
is: SBO:0000185
name: choline transport via diffusion (cytosol to mitochondria)
reversible: true
fast: false
kinetic law: MODEL1310110040#

metaR ALR2
is: SBO:0000176
type: Reaction
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.21
name: aldose reductase (methylglyoxal)
reversible: false
is described by: ECO:0000269
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaR NACHEX15ly
reversible: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110040#

metaM ksii core4 pre10 g
has only substance units: false
constant: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
is: SBO:0000247
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
type: Species
is: CHEBI:28067
initial concentration: 1.0

metaM asn L e
initial concentration: 1.0
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:17196
name: L-asparagine
has only substance units: false

metaR G14T20g
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
type: Reaction
modifier: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110040#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176

metaR MTHFD2m
is described by: ECO:0000254
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
modifier: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a89451f2_76c0_433c_82cb_38e1c9de9def
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:217
has only substance units: false
constant: false
boundary condition: true
is: P05091
is: SBO:0000252
name: ALDH2

metaR FACOAL204
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is described by: ECO:0000269
reactant: MODEL1310110040#
name: fatty-acid--CoA ligase
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176

metaM fe3 e
is: HMDB12943
boundary condition: false
initial concentration: 1.0
is: CHEBI:29034
constant: false
initial amount: NaN
name: Fe3+
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847

http://identifiers.org/biomodels.db/MODEL1310110040#_290e1072_0f3a_41aa_b0b2_d8418e3da25b
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P31040
name: SDHA
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6389
initial amount: NaN

metaR r0670
reactant: MODEL1310110040#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false
type: Reaction
reversible: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_db1311fd_46f7_4632_bfab_ae7e14c0eeff
boundary condition: true
is encoded by: hsa:6005
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: RHAG
is: Q96E98
type: Species
has only substance units: false

metaM 3ivcrn c
type: Species
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
is: C05998
name: 3-hydroxy-isovaleryl carnitine
initial amount: NaN
is: HMDB06870
notes: FORMULA: C12H23NO5 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_0c8c0864_5949_4084_a886_ed9e3554b222
boundary condition: true
type: Species
is encoded by: hsa:3033
name: HADH
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q16836

metaM 3hmbcoa m
has only substance units: false
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
initial concentration: 1.0
is: HMDB01356
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaR CSAPASEly
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110040#
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
type: Reaction
is described by: ECO:0000000

metaR GALASE18ly
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
modifier: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR PGLYCt
kinetic law: MODEL1310110040#
product: MODEL1310110040#
name: phosphatidylglycerol transport
type: Reaction
reactant: MODEL1310110040#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_37ce4413_e880_42a2_a894_0c0606d08329
type: Species
is: Q96JQ3
initial concentration: NaN
constant: false
initial amount: NaN
name: CSAD
has only substance units: false
is encoded by: hsa:51380
boundary condition: true
is: SBO:0000252

metaR FACOAL203
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
name: fatty-acid--CoA ligase
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_eace087c_ab60_4376_8e2a_e9678c6b36de
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: PDE1B
type: Species
is encoded by: hsa:5153
is: Q7Z364
has only substance units: false
is: SBO:0000252

metaM gd1a hs g
constant: false
initial amount: NaN
is: CHEBI:58397
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: N-acetylneuraminosyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminosyl)-D-galactosyl-D-glucosylceramide dianion
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5c1a3b4b_7e40_449b_9d72_ed2a00087139
is encoded by: hsa:5091
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: PC
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR GGH 7DHFe
modifier: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7DHF), extracellular

metaR r0009
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110040#
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reversible: false

metaM dcacoa c
is: HMDB06404
has only substance units: false
initial concentration: 1.0
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
is: SBO:0000247
is: C05274
is: CHEBI:61430
constant: false
boundary condition: false

metaR FAOXMC10OHMC10r
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(MC10-->w-OHMC10)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_e5ecb109_b909_4eae_8829_520d2c878d1b
is encoded by: hsa:114799
name: ESCO1
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q5FWF5
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM succ m
is: C00042
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00254
type: Species
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate

http://identifiers.org/biomodels.db/MODEL1310110040#_203f18d8_3310_4d63_8efb_0f9f0f7ff906
name: DHCR24
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1718
initial amount: NaN
is: SBO:0000252
is: Q15392
type: Species
has only substance units: false
constant: false

metaR r2366
kinetic law: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185

metaM sphgn c
boundary condition: false
is: HMDB00269
initial concentration: 1.0
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57817
name: sphinganine(1+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_72012fd4_0bac_45b9_9606_7d7c8c3a931f
type: Species
is encoded by: hsa:347734
initial concentration: NaN
boundary condition: true
is: Q8TB61
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC35B2

http://identifiers.org/biomodels.db/MODEL1310110040#_3c340044_b360_425a_8e3a_3d8572741680
is encoded by: hsa:30833
boundary condition: true
type: Species
name: NT5C
initial concentration: NaN
constant: false
is: Q8TCD5
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM T antigen g
initial concentration: 1.0
notes: FORMULA: C14H24NO10X CHARGE: 0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:22783
name: T antigen (core 1)
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_f47d1bc1_d994_4913_8c75_b5ff8a751a63
is: Q5JPA4
name: SLCO1C1
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:53919
is: SBO:0000252

metaR FAOXC2251836m
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110040#
is: SBO:0000176
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5bb6184f_9b4b_4c84_89d2_f38cbbf25749
initial amount: NaN
has only substance units: false
is encoded by: hsa:2222
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P37268
boundary condition: true
name: FDFT1

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110040#
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM 3mox4hoxm c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
is: SBO:0000247
constant: false
is: HMDB00291
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:27622
name: 3-Methoxy-4-hydroxymandelate

metaM tststerone r
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17347
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
type: Species
name: testosterone
boundary condition: false
is: HMDB00234

metaR GLYOp
reactant: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
reversible: false
product: MODEL1310110040#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
name: glycine oxidase, perixosomal

metaM hspg l
is: SBO:0000247
is: HMDB01993
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
boundary condition: false
initial concentration: 1.0
is: CHEBI:17899
constant: false
has only substance units: false
type: Species
name: heparan sulfate proteoglycan
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_05f4189e_6258_490c_8e37_4a3d905a0c7d
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: DPYD
initial concentration: NaN
is: Q12882
is encoded by: hsa:1806
is: SBO:0000252
has only substance units: false

metaM tetdece1crn c
type: Species
is: HMDB02014
initial amount: NaN
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR FACOAL224
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
fast: false
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110040#_96bffb1d_2593_4ba4_bc07_4df45890b375
is: SBO:0000252
is encoded by: hsa:7166
initial amount: NaN
type: Species
name: TPH1
constant: false
has only substance units: false
boundary condition: true
is: P17752
initial concentration: NaN

metaM ttetddcoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
type: Species
is: HMDB02288
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: trans5,8tetradecadienoylcoa

metaR r2368
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110040#

metaR GGH 6DHFl
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110040#

metaM ksi pre21 g
boundary condition: false
type: Species
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 21
is: C00130

metaR SPHK21c
reversible: false
type: Reaction
kinetic law: MODEL1310110040#
name: sphingosine kinase 2
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.91
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is described by: ECO:0000269

metaM ksi deg28 l
is: SBO:0000247
name: keratan sulfate I, degradation product 28
is: HMDB01354
is: CHEBI:57455
initial amount: NaN
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_b600a0ca_2933_4c38_89e6_9353e1ef1e12
constant: false
has only substance units: false
name: ACP1
type: Species
is: SBO:0000252
is encoded by: hsa:52
boundary condition: true
is: Q59EH3
initial amount: NaN
initial concentration: NaN

metaM fad c
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
initial concentration: 1.0
has only substance units: false
is: HMDB01248
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaM dlnlcgcoa m
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979

metaM csn c
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
name: cytosine
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00630
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:16040

http://identifiers.org/biomodels.db/MODEL1310110040#_adcfd2db_93a4_471b_99d0_59905bc1d4d7
name: _X63359_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:X63359
type: Species
initial amount: NaN
initial concentration: NaN

metaR FOLt2le
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: folate transport via anion exchange
reactant: MODEL1310110040#
reversible: true
fast: false
product: MODEL1310110040#
is: SBO:0000185

metaR r2369
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction

metaM c6crn x
name: hexanoyl carnitine
initial amount: NaN
boundary condition: false
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

metaM 2dr5p c
is: CHEBI:57651
is: HMDB01031
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR HMGCOASim
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_d998b59a_128a_402a_82c9_0a231c55fb23
name: CA9
initial amount: NaN
has only substance units: false
is encoded by: hsa:768
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q16790

metaR INSTt2r
reactant: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110040#
name: inositol transport in via proton symport
reversible: true
fast: false
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110040#

metaR FACOAL226
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM xan c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00292
constant: false
type: Species
has only substance units: false
is: C00385
initial amount: NaN
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
boundary condition: false
is: CHEBI:17712
name: Xanthine

metaR S6TASE20ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110040#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is: SBO:0000176
reversible: true

metaR r0317
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
type: Reaction

metaM chol n
is: SBO:0000247
type: Species
name: choline
is: CHEBI:15354
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_2282091d_552d_45b0_9c78_4244e82cc9e9
constant: false
name: ACADM
type: Species
initial concentration: NaN
is: P11310
is: SBO:0000252
has only substance units: false
is encoded by: hsa:34
initial amount: NaN
boundary condition: true

metaM pre prot r
initial amount: NaN
is: CHEBI:16038
type: Species
name: glycophosphatidylinositol (GPI)-anchored protein precursor
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: XY CHARGE: 0
boundary condition: false
initial concentration: 1.0

metaR HIVCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaM dolp L c
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: dolichyl phosphate(2-)
initial concentration: 1.0
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
boundary condition: false
type: Species

metaR LTC4CP
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#

metaR r2362
is described by: ECO:0000000
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110040#
fast: false
type: Reaction
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_9961151d_8f53_4361_9430_e3fbcd8a198a
is: SBO:0000252
boundary condition: true
name: AK7
is encoded by: hsa:122481
initial amount: NaN
type: Species
is: Q96M32
initial concentration: NaN
constant: false
has only substance units: false

metaM hpdcacrn c
boundary condition: false
initial concentration: 1.0
name: heptadecanoyl carnitine
is: HMDB06210
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
constant: false

metaM ksi deg35 l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
has only substance units: false
type: Species
is: CHEBI:12936
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 35

metaR MAGt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
product: MODEL1310110040#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110040#
name: monoacylglycerol 2 transport
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185

metaR RE3218C
product: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2
name: RE3218
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_1f15ada3_ab66_4480_9d22_31109fa322f0
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: Q92521
boundary condition: true
name: PIGB
is encoded by: hsa:9488
type: Species

metaM dcholcoa c
has only substance units: false
name: chenodeoxycholoyl coenzyme a
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28701
is: HMDB06292
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaR RE2269E
product: MODEL1310110040#
is: SBO:0000176
type: Reaction
name: RE2269
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.21.39
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
fast: false
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true

metaM Lpipecol x
initial amount: NaN
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
is: SBO:0000247
name: L-pipecolic acid
is: CHEBI:30913
has only substance units: false
boundary condition: false
is: HMDB00716
constant: false
type: Species
initial concentration: 1.0

metaR THRPHELAT2tc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR BHBt
name: (R)-3-Hydroxybutanoate transport via H+ symport
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reversible: true

metaR G14T9g
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
reversible: false
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110040#
product: MODEL1310110040#

metaR LEUKTRA4t
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
name: leukotriene A4 transport

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
reversible: true
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110040#

metaR r0311
type: Reaction
modifier: MODEL1310110040#
fast: false
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
product: MODEL1310110040#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3

metaR r2363
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110040#_2a426785_b9c6_4099_9b92_ce6daf4218dd
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8869
name: ST3GAL5
constant: false
initial amount: NaN
is: Q9UNP4
type: Species

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_67023cf4_5a42_42d6_acf3_37ba201e3298
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5831
initial amount: NaN
initial concentration: NaN
name: PYCR1
type: Species
is: A6NFM2

metaR PPCDC
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
name: phosphopantothenoylcysteine decarboxylase
fast: false
reactant: MODEL1310110040#

metaM hs deg13 l
name: heparan sulfate, degradation product 13
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: SBO:0000247
is: HMDB06254

metaM dlnlcgcoa r
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: C03595
has only substance units: false
name: dihomo-gamma-linolenyl coenzyme A
type: Species
boundary condition: false
is: CHEBI:27979

metaR C180CPT1
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
modifier: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
name: production of stearoylcarnitine
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_f5164dff_db8b_456f_90b3_576cddca1088
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: _8781_1_c
initial concentration: NaN
is encoded by: hsa:8781
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_7cb1dfb0_8a60_4d52_9555_f93dd76e6b46
is: C9JT23
name: NDUFA11
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:126328

http://identifiers.org/biomodels.db/MODEL1310110040#_c5b2df8f_fbb8_40dd_86d9_354a7aee7a73
initial concentration: NaN
initial amount: NaN
is: P49448
has only substance units: false
is encoded by: hsa:2747
is: SBO:0000252
constant: false
name: GLUD2
type: Species
boundary condition: true

metaR GTHRDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_87dc95e5_8c60_48c5_b389_f5678ce04bbc
boundary condition: true
type: Species
is: Q5T4Y1
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110040#_50f7c645_fbd6_4349_80ff_69af95298e49
name: PPA2
initial amount: NaN
is encoded by: hsa:27068
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_8b15005a_27e1_4f63_8dbd_d119b544323d
constant: false
type: Species
is encoded by: hsa:7108
boundary condition: true
is: O76062
is: SBO:0000252
initial concentration: NaN
name: TM7SF2
has only substance units: false
initial amount: NaN

metaR r2364
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110040#
type: Reaction
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaR ORNTArm
is version of: http://identifiers.org/ec-code/2.6.1.13
reversible: true
product: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: ornithine transaminase reversible (m)
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
is: SBO:0000176

metaM f26bp c
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:58579
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
is: HMDB01047
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665

metaM malthx e
boundary condition: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
name: Maltohexaose
constant: false
is: SBO:0000247
has only substance units: false
is: C01936
initial concentration: 1.0
type: Species

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_73df578c_bad7_4cc1_a8f2_940c36258afe
is encoded by: hsa:26266
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9UKG4
initial concentration: NaN
has only substance units: false
name: SLC13A4
boundary condition: true

metaM chol m
is: CHEBI:15354
name: choline
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00097
initial amount: NaN

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR r2365
product: MODEL1310110040#
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110040#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_0f7c478f_d049_4559_83c3_7dbc5a155add
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:22978
is: P49902
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NT5C2

metaR GLCURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
type: Reaction
name: glucuronate transport into lysososme
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
reversible: true

metaR r0527
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
product: MODEL1310110040#

metaR C180CPT2
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
reversible: false
type: Reaction
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-stearoyl transferase

http://identifiers.org/biomodels.db/MODEL1310110040#_cb1658dd_625d_430c_b58d_2091ebd1d5b1
is encoded by: hsa:23236
type: Species
name: PLCB1
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9NQ66
boundary condition: true

metaM hspg e
name: heparan sulfate proteoglycan
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32366
is: SBO:0000247
constant: false
is: HMDB02259
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110040#_b360499a_ea48_44ab_a5af_00d3c3644483
is encoded by: hsa:AI684467
name: _AI684467_1_m
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR EHGLAT2m
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reversible: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reactant: MODEL1310110040#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110040#
is described by: ECO:0000304
modifier: MODEL1310110040#

metaR PAIL4P HStn
reactant: MODEL1310110040#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
is: SBO:0000185
product: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true

metaR DCSPTN1CPT2
name: carnitine transferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1e5e715e_e74a_4a91_b57f_880a39c16c9e
is: Q9NRA0
has only substance units: false
is encoded by: hsa:56848
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SPHK2
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_d9c8b636_6af0_483a_9fb0_4cbb5bad7789
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: CHKA
is encoded by: hsa:1119
is: SBO:0000252
has only substance units: false

metaR C161CPT22
fast: false
name: C161 transport into the mitochondria
modifier: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
reversible: false
product: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_44e2c3c9_afa8_4b4a_b320_fa8725fc868f
has part: O75964
is encoded by: hsa:515
has only substance units: false
has part: Q6IBB3
boundary condition: true
has part: P46459
is encoded by: hsa:10476
has part: A0PJH2
type: Species
is encoded by: hsa:522
has part: P56385
is encoded by: hsa:10632
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9551
is encoded by: hsa:516
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:521
is: SBO:0000297
has part: P05496
constant: false
has part: Q08ET0
is encoded by: hsa:4905

metaM tyr L e
constant: false
has only substance units: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
is: SBO:0000247
type: Species
boundary condition: false
name: L-tyrosine
initial concentration: 1.0
is: CHEBI:17895
initial amount: NaN

metaM HC02205 c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:28099
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
constant: false
name: prostaglandin-b2
type: Species

metaR B3GALT44g
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.62
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
name: Beta-1,3-galactosyltransferase 4
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_ed17b1c2_ec7b_474e_bd5b_a3e8fa1b1c16
is: Q9H3H5
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1798
name: DPAGT1
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_bf99a2f7_ca3d_4177_9a31_5f53942edb2d
constant: false
name: GAPDH
is: E7EUT4
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2597

metaM sql r
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15440
constant: false
is: HMDB00256
has only substance units: false
name: squalene

http://identifiers.org/biomodels.db/MODEL1310110040#_28e20b1e_5e4c_4fc6_b320_78dad9e19731
constant: false
name: B4GALT2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O60909
initial amount: NaN
is encoded by: hsa:8704
type: Species

metaM ksi deg13 l
is: HMDB01354
constant: false
boundary condition: false
is: CHEBI:57455
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 13
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
initial amount: NaN
type: Species

metaM ser D c
is: CHEBI:16523
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
name: D-serine
initial concentration: 1.0
is: HMDB03406
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_14383c89_045d_4a5c_bc1b_2663fcd93e48
boundary condition: true
has only substance units: false
constant: false
name: ZADH2
is: Q8N4Q0
type: Species
is: SBO:0000252
is encoded by: hsa:284273
initial amount: NaN
initial concentration: NaN

metaR P450SCC1m
is: SBO:0000176
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110040#
type: Reaction
reversible: true
is described by: ECO:0000134
name: cholesterol monooxygenase
kinetic law: MODEL1310110040#

metaR DCSPTN1CPT1
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is: SBO:0000176
name: carnitine O-palmitoyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM dem2emgacpail prot hs r
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
is: C00458
initial amount: NaN
is: SBO:0000247
is: CHEBI:16311
is: HMDB00998
constant: false
initial concentration: 1.0
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol

metaM c10crn c
initial amount: NaN
is: HMDB00651
type: Species
name: decanoyl carnitine
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C17H33NO4 CHARGE: 0

metaR KHte
fast: false
kinetic law: MODEL1310110040#
is: SBO:0000185
name: KHte
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_f4539070_b85e_414f_93e8_3e3c3a9409ba
name: FUT8
boundary condition: true
is encoded by: hsa:2530
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q9BYC5
type: Species
initial concentration: NaN

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_508fc463_5e1a_4cfc_b9bf_2adbe32f09df
is: Q16678
boundary condition: true
is encoded by: hsa:1545
name: CYP1B1
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_ab83a910_9ae1_441f_b3ea_e93b761f69d1
name: ACAA1
type: Species
is: Q96CA6
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:30

http://identifiers.org/biomodels.db/MODEL1310110040#_337c63bf_2776_4993_ad85_d7049dabfe56
boundary condition: true
is encoded by: hsa:65010
name: SLC26A6
is: Q548A7
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR MANt4
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: D-mannose transport via sodium cotransport
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

metaM 2mpdhl m
type: Species
constant: false
initial amount: NaN
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
is: SBO:0000247
has only substance units: false

metaM tyr L c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
name: L-tyrosine
boundary condition: false
initial concentration: 1.0
is: HMDB00158
type: Species
is: SBO:0000247
is: CHEBI:17895

metaR RE1520M
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1520
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
modifier: MODEL1310110040#
type: Reaction

metaR r2360
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport

metaR XOLDIOLONEt
reactant: MODEL1310110040#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
is: SBO:0000185
reversible: true
name: lipid, flip-flop intracellular transport

metaM thbpt c
constant: false
type: Species
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: CHEBI:15372
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
is: HMDB00027
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_54feef1f_e060_477a_81fb_86a89cc2dd15
has only substance units: false
name: _AI378339_1_m
constant: false
initial amount: NaN
is encoded by: hsa:AI378339
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM dcholcoa r
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28701
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaM ksi deg8 l
name: keratan sulfate I, degradation product 8
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
type: Species
constant: false

metaM HC02205 e
is: CHEBI:28099
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
type: Species
initial amount: NaN

metaR ALOX52
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.13.11.34
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
fast: false
name: Arachidonate 5-lipoxygenase
type: Reaction

metaM ser D e
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
has only substance units: false
is: CHEBI:16523
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: D-serine

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM gluside hs r
type: Species
name: D-glucosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
is: CHEBI:18368
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_71b85b76_2462_4410_a7ff_f480045a6b40
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: PDE9A
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152

metaR r2361
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#

metaR DOLPMT3 Ler
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
product: MODEL1310110040#

metaM 3dsphgn c
initial amount: NaN
is: CHEBI:58299
initial concentration: 1.0
is: HMDB01480
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
boundary condition: false
type: Species
constant: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR ACGPID
is described by: ECO:0000269
kinetic law: MODEL1310110040#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.89
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
type: Reaction
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false

metaM retinal c
boundary condition: false
is: CHEBI:15035
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB01358
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
name: retinal

http://identifiers.org/biomodels.db/MODEL1310110040#_aa0e94cb_7c91_479e_aca0_243eb9dfdeb7
has part: E5KS60
name: SUCLG1:SUCLA2
is encoded by: hsa:8803
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000297
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_fd216cf1_a3da_4976_9e9a_625534c7cb09
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: ELOVL5
is: F6SH78
has only substance units: false
is encoded by: hsa:60481
boundary condition: true
initial amount: NaN

metaM idp n
type: Species
name: IDP(3-)
initial concentration: 1.0
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
boundary condition: false
is: HMDB03335
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR SERGLYexR
fast: false
modifier: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110040#
is described by: ECO:0000304
type: Reaction
name: L-Serine/Glycine reversible exchange
reactant: MODEL1310110040#
reversible: true

metaM tymsf e
type: Species
is: HMDB06409
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
constant: false
initial amount: NaN
name: Tyramine O-sulfate

metaM csn e
is: CHEBI:16040
initial concentration: 1.0
constant: false
is: HMDB00630
is: SBO:0000247
type: Species
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
has only substance units: false
boundary condition: false
initial amount: NaN
name: cytosine

metaR CYTK7
type: Reaction
kinetic law: MODEL1310110040#
is: SBO:0000176
name: cytidylate kinase (CMP,UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR S6TASE16ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000176
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110040#

metaR CMPSASn
is version of: http://identifiers.org/ec-code/2.7.7.43
modifier: MODEL1310110040#
reversible: false
is described by: ECO:0000304
name: CMP sialic acid synthase, nuclear
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false

metaR BAAT1x
is described by: ECO:0000269
reversible: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reactant: MODEL1310110040#
name: bile acid Coenzyme A: amino acid N-acyltransferase
modifier: MODEL1310110040#
fast: false

metaR PDE4
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.35
is version of: http://identifiers.org/ec-code/3.1.4.17
modifier: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
reversible: false

metaM 9 cis retfa e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
constant: false
type: Species
is: HMDB06559
name: fatty acid 9-cis-retinol
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_38773221_87d4_4198_96a2_2ecd0ce8b0e7
name: FPGS
constant: false
is encoded by: hsa:2356
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q05932

http://identifiers.org/biomodels.db/MODEL1310110040#_7d27d0a0_9869_46e4_9e2a_989c879d16fd
name: PSPH
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P78330
initial concentration: NaN
constant: false
is encoded by: hsa:5723
has only substance units: false

metaM ksii core2 deg5 l
name: keratan sulfate II (core 2-linked), degradation product 5
notes: FORMULA: C50H82N4O38SX CHARGE: -1
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00143
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
constant: false

metaR CYTK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
name: cytidylate kinase (CMP,CTP)
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#

metaM akg c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
constant: false
name: 2-Oxoglutarate
has only substance units: false
initial amount: NaN
is: CHEBI:16810
is: HMDB00208

http://identifiers.org/biomodels.db/MODEL1310110040#_2783713e_557c_49fc_832b_36dfbcf7d4e9
initial concentration: NaN
constant: false
name: SGPP1
type: Species
is encoded by: hsa:81537
is: Q9BX95
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR ALA DASH DTDe
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: exit of D-alanine from the enterocytes
reversible: false
is: SBO:0000185
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed. NOTES:no specific transporter for exit of D-alanine could be found, so diffusion mechanism is assumed.
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_618b1555_3cb4_4380_af38_ca557b6de39e
has only substance units: false
constant: false
is: Q6IBB5
name: NDUFA1
type: Species
is encoded by: hsa:4694
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_a19318ff_7f8e_487a_9276_69cf1c47bd27
constant: false
name: ACAD8
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:27034
is: Q6ZWP6

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR CYTK9
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
name: cytidylate kinase (CMP,dCTP)

http://identifiers.org/biomodels.db/MODEL1310110040#_2a71ef1b_2fa8_4300_9532_795dd9a1e06c
is: E9KL44
name: HADHA
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:3030

metaR r0879
fast: false
reactant: MODEL1310110040#
reversible: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
product: MODEL1310110040#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110040#

metaM tymsf c
type: Species
boundary condition: false
has only substance units: false
is: HMDB06409
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
constant: false
name: Tyramine O-sulfate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_72024ea9_12dd_4534_abad_9004205bdb0c
is encoded by: hsa:8883
has only substance units: false
is: A8MU28
type: Species
name: NAE1
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR PDE1
type: Reaction
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.4.17
reactant: MODEL1310110040#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is version of: http://identifiers.org/ec-code/3.1.4.35
reversible: false
fast: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176

metaR RE2626M
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110040#
reversible: true
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
name: RE2626
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_678a6223_433b_4255_b3b0_95b6116111f9
type: Species
is: SBO:0000252
name: CA12
is: O43570
initial concentration: NaN
constant: false
is encoded by: hsa:771
initial amount: NaN
boundary condition: true
has only substance units: false

metaM hpdcacrn m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB06210
constant: false
has only substance units: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
name: heptadecanoyl carnitine
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_b4b5fca1_ed4b_414b_8d65_66f69120f826
initial amount: NaN
boundary condition: true
name: ATP5F1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:515
type: Species
has only substance units: false
constant: false

metaM pan4p m
initial concentration: 1.0
is: CHEBI:47942
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247
type: Species
boundary condition: false
name: pantetheine 4'-phosphate(2-)
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7511c249_290d_4693_bc41_cb4134ada68b
is encoded by: hsa:85365
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: ALG2
constant: false
boundary condition: true

metaR MG3er
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum

metaM c10crn e
notes: FORMULA: C17H33NO4 CHARGE: 0
constant: false
name: decanoyl carnitine
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00651
has only substance units: false

metaR CYTK8
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110040#
name: cytidylate kinase (CMP,dATP)
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_1883c0e2_18a7_4ba4_83b4_f8ca772828e8
name: ALPPL2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:251
initial amount: NaN
is: P10696
type: Species
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_ed9c68be_2e1a_4e23_8a1c_22b7d9992861
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM akg e
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 2-oxoglutarate(2-)
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00208
is: CHEBI:16810
constant: false

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM chol e
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00097
name: Choline
initial concentration: 1.0
is: C00114
is: CHEBI:15354
type: Species
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_36fa06b0_440a_4a6f_a000_9addf37e3cf7
is: P05091
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ALDH2
is encoded by: hsa:217
initial concentration: NaN
type: Species

metaR C6DCCACT
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR GALtly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: galactose efflux from lysosome
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: false
product: MODEL1310110040#
type: Reaction
fast: false

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR FAOXC150m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Beta oxidation of long chain fatty acid (odd chain)
fast: false
product: MODEL1310110040#
type: Reaction
reversible: false
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ

metaR GLYtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110040#

metaM chol c
type: Species
name: Choline
is: CHEBI:15354
is: HMDB00097
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_208fea5d_8d0a_48e5_b9d5_facc1228e6c0
is encoded by: hsa:27115
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9NP56
type: Species
name: PDE7B
boundary condition: true
initial concentration: NaN

metaM rib D c
is: SBO:0000247
type: Species
name: D-ribose
constant: false
initial amount: NaN
is: HMDB00283
has only substance units: false
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0
boundary condition: false

metaM HC01231 m
is: CHEBI:58480
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
has only substance units: false

metaR r0686
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110040#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false

metaR TDCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaM tetdec2coa c
is: HMDB02014
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: tetradecadienoylcoa
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e382cbe5_fb7f_4f35_8a98_a81b399c72ca
type: Species
name: SLC35D1
initial amount: NaN
is encoded by: hsa:23169
boundary condition: true
is: Q9NTN3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR R group phosphotase 2
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: R group phosphotase 2

metaM tststerone c
initial amount: NaN
constant: false
name: testosterone
is: SBO:0000247
boundary condition: false
is: HMDB00234
has only substance units: false
type: Species
is: CHEBI:17347
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535

metaR DIDPtn
name: dIDP nuclear transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_3eafc9e5_d74a_44c8_8f54_e1395fd3b02b
is: P20594
type: Species
is encoded by: hsa:4882
constant: false
initial concentration: NaN
boundary condition: true
name: NPR2
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR C142ACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR COAtr
is: SBO:0000185
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
product: MODEL1310110040#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
name: COA transporter, endoplasmic reticulum

metaM dttp m
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
is: SBO:0000247
is: C00459
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: dTTP
is: CHEBI:37568
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c26227c1_e6ba_4ffd_bf8c_b72bf9684fc3
is: Q9BRC7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84812
constant: false
type: Species
boundary condition: true
name: PLCD4
initial amount: NaN
has only substance units: false

metaR R group phosphotase 1
fast: false
product: MODEL1310110040#
type: Reaction
reversible: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_2741a426_1e34_4acd_855d_fb84d2aef377
is encoded by: hsa:J03866
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _J03866_1_m
has only substance units: false
is: SBO:0000252
type: Species

metaR r0688
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110040#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110040#

metaM arachdcoa m
boundary condition: false
is: CHEBI:57368
type: Species
name: arachidonoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
is: HMDB06523

metaM idp e
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB03335
is: CHEBI:58280
name: IDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110040#_de95e47c_e165_4c07_81e7_3966dc43400e
boundary condition: true
name: PDHB
initial concentration: NaN
type: Species
constant: false
is: P11177
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5162
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_34feced0_3fa9_4a8d_992b_c8a7b11e6565
is: SBO:0000252
is encoded by: hsa:5152
type: Species
name: PDE9A
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaM tststerone e
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: testosterone
constant: false
is: CHEBI:17347
is: SBO:0000247
initial concentration: 1.0
is: HMDB00234

http://identifiers.org/biomodels.db/MODEL1310110040#_c855ae86_06d9_461f_821a_3f73c4da6724
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:29920
initial amount: NaN
is: SBO:0000252
name: PYCR2
is: Q96C36

metaR DGK1
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
reactant: MODEL1310110040#
fast: false
type: Reaction
name: deoxyguanylate kinase (dGMP:ATP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_9b6f46c6_383f_4530_9d24_f4bb0a996b74
type: Species
is: P13929
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2027
name: ENO3
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_5215a4a0_a9f9_47f5_9d3f_c8d8f0b995ae
initial concentration: NaN
constant: false
name: NDUFS7
is encoded by: hsa:374291
type: Species
initial amount: NaN
has only substance units: false
is: O75251
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_2529e900_c4a8_483b_b3ce_2a0e53637910
has only substance units: false
constant: false
is encoded by: hsa:4967
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q02218
initial amount: NaN
name: OGDH
boundary condition: true

metaR RPE
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/5.1.3.1
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110040#
name: ribulose 5-phosphate 3-epimerase
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110040#_eacae9c4_5f34_48fd_9c30_d2f5388d322b
type: Species
is: SBO:0000252
is encoded by: hsa:23057
boundary condition: true
constant: false
initial concentration: NaN
name: NMNAT2
has only substance units: false
initial amount: NaN
is: Q9BZQ4

metaR SRTNt6 2 r
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)

metaR C81CRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_840c5e38_ed12_49b7_be5c_060ee9ad97a4
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: IK
is: Q13123
initial amount: NaN
is encoded by: hsa:3550
constant: false

metaM ala L e
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
is: HMDB00161
name: L-alanine
is: CHEBI:16977
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_dc02a032_7daf_4d1f_b197_3ddf7a1cd8cc
initial concentration: NaN
is: Q5JAM2
type: Species
name: ALAS1
is encoded by: hsa:211
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_4b4a54d4_859a_4573_85fb_69b45948bc06
name: ITPKB
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3707
initial amount: NaN
is: P27987
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_d8913495_45cd_4982_8222_55b15f3cf8ee
is encoded by: hsa:4881
type: Species
has only substance units: false
is: P16066
initial concentration: NaN
name: NPR1
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaM sebacid c
name: sebacicacid
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00792
initial amount: NaN
is: C08277
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
boundary condition: false

metaR S6T9g
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110040#

metaM CE2424 m
boundary condition: false
has only substance units: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: CHEBI:28387
is: HMDB11123
is: SBO:0000247
type: Species
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_51ed6886_5daa_4989_bc65_faffed742fc2
constant: false
is: SBO:0000252
name: NPR2
type: Species
has only substance units: false
is encoded by: hsa:4882
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_da426d28_1c2e_42d1_91a1_c446f0f6d2fe
boundary condition: true
has only substance units: false
name: LPL
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:4023
is: P06858
is: SBO:0000252
type: Species

metaM dlnlcgcoa c
initial amount: NaN
constant: false
name: dihomo-gamma-linolenyl coenzyme A
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979

metaM akg m
is: C00026
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
boundary condition: false
name: 2-Oxoglutarate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16810
is: HMDB00208
type: Species

metaM ddsmsterol r
constant: false
initial concentration: 1.0
type: Species
is: HMDB03896
boundary condition: false
name: 7-dehydrodesmosterol
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: CHEBI:27910
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_28df5110_c360_452d_af94_0f8ac2b7c5d5
has only substance units: false
is encoded by: hsa:57379
initial amount: NaN
name: AICDA
type: Species
is: Q546Y9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR FMNAT
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.7.2
reversible: false
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: FMN adenylyltransferase
type: Reaction
fast: false
is described by: ECO:0000134
is: SBO:0000176

metaM ddcacoa x
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57375
is: HMDB03571
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR RE2999M
reversible: true
is: SBO:0000176
name: RE2999
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaM ksi pre2 g
type: Species
is: HMDB00175
is: C00130
constant: false
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 2
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: CHEBI:58053
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b7e9252f_b57c_4a6c_b1b9_5c7a1eb9e137
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8310
name: ACOX3
type: Species
constant: false
boundary condition: true
is: O15254

metaR GLYtp
is described by: ECO:0000000
name: glycine passive transport to peroxisome
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
fast: false
type: Reaction

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR r0885
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_10edecaa_ce4e_45f9_811e_379ba4bd3677
type: Species
is: SBO:0000252
has only substance units: false
is: P14550
initial amount: NaN
constant: false
is encoded by: hsa:10327
initial concentration: NaN
boundary condition: true
name: AKR1A1

metaR r1800
is described by: ECO:0000000
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#
modifier: MODEL1310110040#

metaR GLNt4
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
reversible: false
type: Reaction
name: L-glutamine reversible transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_5863a376_9e2f_46e0_b99f_1770821a3f3f
constant: false
is: O95168
name: NDUFB4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4710
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR GLCAASE8ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
fast: false
reactant: MODEL1310110040#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110040#
is described by: ECO:0000269

metaM rib D e
name: D-ribose
is: HMDB00283
type: Species
has only substance units: false
is: CHEBI:16988
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaM methf m
type: Species
name: (6R)-5,10-methenyltetrahydrofolate
constant: false
is: SBO:0000247
is: HMDB01354
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_761d86ec_0dd8_4fad_a1a6_31247b2160bf
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:522
is: Q6NZ59
type: Species
initial amount: NaN
has only substance units: false
name: ATP5J

metaR Asn X Ser Thrtr
reactant: MODEL1310110040#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
reversible: true
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaR RETFA
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol acyltransferase
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_8f484bf8_7fd9_496a_8c10_b0ad641447d4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: ENTPD1
is: Q86VV3
type: Species
is encoded by: hsa:953
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_a02a863b_cbf6_463c_a318_77742447f472
type: Species
is encoded by: hsa:AI620219
name: _AI620219_1_c
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM HC01376 m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
type: Species
boundary condition: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
constant: false
initial amount: NaN
is: CHEBI:28692

metaR FAOXC16DCr
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM ala L c
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
is: HMDB00161
is: CHEBI:16977
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_b02ff621_c91f_4056_a45a_dd6149d634da
is encoded by: hsa:56922
type: Species
has part: Q96RQ3
is encoded by: hsa:64087
is: SBO:0000297
has part: Q9HCC0
initial amount: NaN
has only substance units: false
name: MCCC1:MCCC2
initial concentration: NaN
constant: false
boundary condition: true

metaR VALt5m
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
type: Reaction
reversible: true
kinetic law: MODEL1310110040#
name: Valine reversible mitochondrial transport

metaR PI34P5K
type: Reaction
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.68
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
kinetic law: MODEL1310110040#
reversible: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8b235a36_ee56_408c_841c_c9090dbca92c
is encoded by: hsa:AA788780
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AA788780_1_c
initial concentration: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7396f8f8_2a75_4f92_aefe_adeb3cd34a2b
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:4597
initial concentration: NaN
type: Species
name: MVD
is: P53602
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e5528767_7237_4188_8320_7526703eb100
is: Q8TD20
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:154091
name: SLC2A12

metaR DGNSKm
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: deoxyguanosine kinase
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a6d29e0a_0aeb_497b_af5b_03a4fda9ad10
is encoded by: hsa:509
is: SBO:0000252
type: Species
has only substance units: false
is: P36542
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ATP5C1

metaM lneldccoa m
name: linoelaidyl coenzyme A
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
constant: false
is: HMDB01064
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164

http://identifiers.org/biomodels.db/MODEL1310110040#_393c6e82_ef8c_4e0a_af08_5ca9957eac63
is: Q9BXI2
boundary condition: true
type: Species
is encoded by: hsa:83884
has only substance units: false
name: SLC25A2
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_95d91df1_541e_4ea0_bf8f_52b8e8602fa6
initial amount: NaN
name: ZADH2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:284273
boundary condition: true
initial concentration: NaN
is: Q4G1C4

http://identifiers.org/biomodels.db/MODEL1310110040#_af25224b_5a4c_4204_8f57_0400a84d6564
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: P49327
initial amount: NaN
is encoded by: hsa:2194
has only substance units: false
boundary condition: true
name: FASN

metaR F1Atg
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: F1alpha transport (from golgi to lysosome)
fast: false
reactant: MODEL1310110040#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

metaM dcsptn1crn c
has only substance units: false
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06321

metaR ACNAM9PL
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is version of: http://identifiers.org/ec-code/2.5.1.56
modifier: MODEL1310110040#
fast: false
reversible: false
product: MODEL1310110040#
reactant: MODEL1310110040#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
is described by: ECO:0000269
kinetic law: MODEL1310110040#

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_5d5bb1d3_d764_4dd9_bb45_53ad128af108
is: SBO:0000252
constant: false
is encoded by: hsa:4537
is: P03897
initial concentration: NaN
boundary condition: true
name: ND3
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_bc3d2d63_c7b8_41be_b203_1695570a64b8
name: XDH
is: P47989
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7498

http://identifiers.org/biomodels.db/MODEL1310110040#_a0fbf6e0_0d28_4359_a62a_8724e4bd2aa7
type: Species
is encoded by: hsa:9487
has only substance units: false
name: PIGL
initial amount: NaN
is: SBO:0000252
is: Q9Y2B2
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2804ef68_d7fc_4031_9141_5e52e611fae8
type: Species
initial concentration: NaN
name: ME2
constant: false
is encoded by: hsa:4200
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: P23368

http://identifiers.org/biomodels.db/MODEL1310110040#_59374dad_ca5f_4e72_86b8_6b070e79106d
is: SBO:0000252
name: MTHFD1L
initial amount: NaN
boundary condition: true
type: Species
is: B2RD24
is encoded by: hsa:25902
constant: false
initial concentration: NaN
has only substance units: false

metaM ksi deg32 l
is: CHEBI:12936
type: Species
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
initial amount: NaN
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 32
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ed91a2e3_7591_414d_bceb_47cdb9b02601
boundary condition: true
name: LEFTY1
is: O75610
is: SBO:0000252
type: Species
is encoded by: hsa:10637
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_6f4dec2b_fbac_41c4_bdb7_ad98cea797b1
boundary condition: true
is: P52824
constant: false
initial concentration: NaN
is: SBO:0000252
name: DGKQ
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1609

http://identifiers.org/biomodels.db/MODEL1310110040#_3ee6a3b4_d1fb_4167_9969_e7ec49e607b6
is: P42765
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10449
has only substance units: false
boundary condition: true
type: Species
constant: false
name: ACAA2
initial amount: NaN

metaR RE2626C
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
name: RE2626
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_29a47550_ec35_4171_a496_fc2ac0f857fd
is: O43678
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:4695
initial amount: NaN
is: SBO:0000252
name: NDUFA2
boundary condition: true

metaM 3m4hpga c
boundary condition: false
is: C05583
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: HMDB04061
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: http://identifiers.org/pubchem.compound/7909
type: Species
is: SBO:0000247

metaM gluside hs c
has only substance units: false
name: D-glucosyl-N-acylsphingosine
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:18368

metaM 5dpmev x
is: HMDB01090
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:15899
name: (R)-5-Diphosphomevalonate
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM datp c
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
name: dATP
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61404
is: C00131
is: HMDB01532
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR PIt7
is: SBO:0000185
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reversible: true
modifier: MODEL1310110040#
name: phosphate transport in/out via three Na+ symporter
type: Reaction
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
fast: false

metaM arachdcoa x
initial amount: NaN
name: arachidonoyl-CoA(4-)
boundary condition: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
is: CHEBI:57368
is: SBO:0000247
is: HMDB06523
initial concentration: 1.0
has only substance units: false

metaM CE5236 n
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
is: HMDB03952
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
has only substance units: false

metaR ADEt
type: Reaction
reversible: true
name: adenine reversible transport, cytosol
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#

metaR ECOAH12m
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is: SBO:0000176
reversible: true
type: Reaction

metaM hs deg17 l
constant: false
type: Species
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
has only substance units: false
is: CHEBI:21338
name: heparan sulfate, degradation product 17
is: HMDB02704
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r0680
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.137
type: Reaction
fast: false
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reversible: true
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_12bc31e7_9a1c_47be_818d_b75e79ec2aab
type: Species
has only substance units: false
initial concentration: NaN
name: DGKE
boundary condition: true
initial amount: NaN
is: A1L4Q0
constant: false
is: SBO:0000252
is encoded by: hsa:8526

metaR 5ADTSTSTERONESte
is: SBO:0000185
product: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
type: Reaction
is described by: ECO:0000000
name: sulfonated testosterone transport
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_1a92a4d2_1f7f_4097_921e_3acb40b76ec2
constant: false
is: Q16348
name: SLC15A2
initial amount: NaN
is encoded by: hsa:6565
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR PIt8
modifier: MODEL1310110040#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
product: MODEL1310110040#
reactant: MODEL1310110040#
name: phosphate transport in/out via Na+ symporter
is: SBO:0000185
kinetic law: MODEL1310110040#
is described by: ECO:0000006
type: Reaction

metaM acgam6p c
is: SBO:0000247
type: Species
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB01062
is: CHEBI:57513
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial concentration: 1.0

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaR r1806
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
is described by: ECO:0000000

metaM ha deg1 l
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: hyaluronan degradation product 1
initial amount: NaN
is: CHEBI:16336
boundary condition: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
initial concentration: 1.0

metaR GALASE12ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is described by: ECO:0000000
modifier: MODEL1310110040#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110040#_eb648ed0_919c_42e0_9ebb_ae7c3da0ffb3
boundary condition: true
is encoded by: hsa:54677
is: E7EQF2
name: CROT
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaR S6TASE2ly
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true

metaR UGLCNACtg
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000269
modifier: MODEL1310110040#
type: Reaction
name: UDP-GlcNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false

metaR COAtl
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
name: CoA transport in lysosome via diffusion
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM cs a deg3 l
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15748
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB00127
has only substance units: false
type: Species

metaR B MANNASEly
reversible: false
kinetic law: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.25
is: SBO:0000176
modifier: MODEL1310110040#
name: beta-mannosidase, lysosomal
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_47aa7563_9122_4e67_8495_130f28f4f0d8
initial concentration: NaN
constant: false
name: PANK4
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:55229
has only substance units: false
is: Q9NVE7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_5095aaf2_99a8_4be2_8c14_386e9431bc02
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: Q16795
boundary condition: true
is encoded by: hsa:4704
name: NDUFA9

metaR RE1447M
product: MODEL1310110040#
name: RE1447
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR GGH 6DHFe
type: Reaction
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6DHF), extracellular
kinetic law: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_c9c861eb_5ce1_48c0_94fa_2665232b357b
has only substance units: false
name: ALDH2
boundary condition: true
type: Species
is: SBO:0000252
is: P05091
constant: false
initial concentration: NaN
is encoded by: hsa:217
initial amount: NaN

metaR COAtm
product: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
fast: false
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
name: CoA transporter
type: Reaction
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_0f79e79b_119e_4fb0_a13d_a217948be296
type: Species
boundary condition: true
is encoded by: hsa:9962
initial amount: NaN
name: SLC23A2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2b8e3d6f_c152_4eea_b8f7_5de37cf16887
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: TMEM91
is encoded by: hsa:641649
type: Species
is: SBO:0000252
is: C9JZ62
initial amount: NaN

metaR RE1447N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110040#
reversible: true
name: RE1447

metaM ura c
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
name: Uracil
is: C00106
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00300
type: Species
is: CHEBI:17568

metaR r1809
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110040#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: false

metaR G5SADrm
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reversible: true

metaM idp c
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
name: IDP(3-)
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:58280
has only substance units: false

metaR DTTPtn
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_533bfca0_b885_43d0_b965_38f8dcf8a88e
name: _AI972237_1_c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:AI972237

http://identifiers.org/biomodels.db/MODEL1310110040#_5599455b_cb39_482b_aa04_4d61e3d1d27e
boundary condition: true
is encoded by: hsa:8818
has only substance units: false
name: DPM2
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: O94777
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_fc50f1c1_8d1d_4b66_a21a_5792cc7fcd9f
name: _W74642_1_c
constant: false
is encoded by: hsa:W74642
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_cb7b8777_fce9_46bb_8689_ab5bb8a260a6
is: Q5JWV8
name: ACSL4
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2182
boundary condition: true
constant: false

metaM lneldccoa c
type: Species
boundary condition: false
initial amount: NaN
name: linoelaidyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/9543677
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: HMDB06521
has only substance units: false

metaR COAtn
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: coenzyme A transport, nuclear
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM gluside hs g
constant: false
is: SBO:0000247
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
is: CHEBI:18368
boundary condition: false
has only substance units: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r0531
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
product: MODEL1310110040#
fast: false
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
type: Reaction
modifier: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_3fea656f_3050_4fac_98db_33b51bcd18a0
is: Q6IB80
constant: false
initial amount: NaN
is encoded by: hsa:4709
initial concentration: NaN
name: NDUFB3
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM dttp n
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
type: Species
is: C00459
is: SBO:0000247
is: HMDB01342
initial concentration: 1.0
has only substance units: false
name: dTTP
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_214cf7fa_be68_416c_94d8_de3dbacb6dca
is encoded by: hsa:55811
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: ADCY10
is: F5GWS5

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
initial amount: NaN
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
type: Species
is: CHEBI:58480
is: SBO:0000247
boundary condition: false

metaM tetdece1crn e
initial concentration: 1.0
name: tetradecenoyl carnitine
boundary condition: false
notes: FORMULA: C21H39NO4 CHARGE: 0
constant: false
has only substance units: false
is: HMDB02014
type: Species
is: SBO:0000247
initial amount: NaN

metaR HTDCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR PYNP2r
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
name: pyrimidine-nucleoside phosphorylase (uracil)
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.2.3
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110040#
reversible: true

metaR PNTEH
name: Hydrolase Class ( RXN R02973)
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reactant: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
product: MODEL1310110040#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_5f35ec5d_3638_4a4d_98a8_277cc1ef3379
has only substance units: false
is: Q9BY49
type: Species
initial concentration: NaN
is encoded by: hsa:55825
name: PECR
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM retfa e
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: SBO:0000247
type: Species
constant: false
name: fatty acid retinol
is: HMDB00508
has only substance units: false
initial amount: NaN
is: CHEBI:15963
initial concentration: 1.0
boundary condition: false

metaM methf c
is: C00445
boundary condition: false
has only substance units: false
constant: false
name: 5,10-Methenyltetrahydrofolate
initial concentration: 1.0
is: CHEBI:57455
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
is: HMDB01354

http://identifiers.org/biomodels.db/MODEL1310110040#_edd65252_9de2_415f_b3be_c4d408cb55f3
initial concentration: NaN
is encoded by: hsa:5283
initial amount: NaN
name: PIGH
is: SBO:0000252
is: Q14442
has only substance units: false
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_f1d16dac_7581_4721_8a8e_79b8818d0761
constant: false
has only substance units: false
is encoded by: hsa:T83654
type: Species
name: _T83654_1_c
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110040#
type: Reaction
fast: false
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
name: coenzyme A transport, peroxisomal

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_d3feeb2e_41a6_40f7_be6a_23a16c8a0d6c
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: P41222
initial concentration: NaN
is encoded by: hsa:5730
name: PTGDS
is: SBO:0000252
boundary condition: true

metaR r0308
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false
is described by: ECO:0000000
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reversible: false
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
reactant: MODEL1310110040#

metaR H6ET3er
fast: false
reversible: false
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.8.1
modifier: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_570280c0_bfb9_4236_a86a_403e9fe65f7f
constant: false
boundary condition: true
is: Q9Y2P5
is encoded by: hsa:10998
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: SLC27A5

metaM cholcoa c
name: choloyl-CoA(4-)
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01374
is: CHEBI:57373
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN
boundary condition: false
type: Species

metaR DESAT16 2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
modifier: MODEL1310110040#
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
reversible: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is version of: http://identifiers.org/ec-code/1.14.19.1

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_41f5f334_fd40_43a9_b845_6e9680a469f4
constant: false
is encoded by: hsa:80055
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q75T13
name: PGAP1
is: SBO:0000252
type: Species

metaR r2352
fast: false
type: Reaction
kinetic law: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_f3e61bc5_9f6f_4cf1_921c_7a00fbe8835e
name: GOT1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P17174
constant: false
type: Species
is encoded by: hsa:2805
has only substance units: false

metaR NADtn
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110040#
fast: false
name: NAD transport, nuclear through pores
is: SBO:0000185
kinetic law: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_51332421_205a_4802_971d_1b456d9d54c2
initial amount: NaN
initial concentration: NaN
is: Q9UNU6
name: CYP8B1
is encoded by: hsa:1582
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r2106
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR KYNATESYN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110040#
is described by: ECO:0000000
reversible: false
fast: false

metaR SR5ARr
fast: false
is described by: ECO:0000134
reactant: MODEL1310110040#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.5
is: SBO:0000176
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
type: Reaction
name: 3-oxo-5-alpha-steroid 4-dehydrogenase

metaR NCKt
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110040#
is: SBO:0000185
type: Reaction
name: Na+/Ca2+-K+ exchange
reversible: true
product: MODEL1310110040#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110040#
modifier: MODEL1310110040#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_0e233084_c5ac_44e5_a643_221be29d551e
is: Q8IWU9
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: TPH2
constant: false
is encoded by: hsa:121278
initial amount: NaN
is: SBO:0000252

metaR PYDXDH
is described by: ECO:0000269
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.2.3.1
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
name: pyridoxal dehydrogenase
kinetic law: MODEL1310110040#
is: SBO:0000176
modifier: MODEL1310110040#
reversible: false
product: MODEL1310110040#
type: Reaction

metaR C18OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR r0539
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
product: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
modifier: MODEL1310110040#

metaR NACHORCTL3le
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: NACHORCTL3le
type: Reaction

metaM fol c
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
name: Folate
has only substance units: false
type: Species
is: HMDB00121
initial concentration: 1.0
boundary condition: false
constant: false

metaR r2107
type: Reaction
modifier: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r2353
product: MODEL1310110040#
reversible: true
fast: false
reactant: MODEL1310110040#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_e1dad6ea_a703_4b8c_a3fd_b68f769a4f20
initial concentration: NaN
is encoded by: hsa:6515
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: SLC2A3
type: Species
initial amount: NaN
is: P11169

metaR G3PD1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: MODEL1310110040#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_0ebbee96_025d_40bf_890c_c6bcc56ea560
is encoded by: hsa:9551
name: ATP5J2
initial concentration: NaN
is: F8W7V3
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR NDP8ex
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
reactant: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular
type: Reaction
modifier: MODEL1310110040#

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r0998
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
type: Reaction
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110040#

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaR PSt3
product: MODEL1310110040#
name: phosphatidylserine transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM thym m
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: thymine
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00262
is: CHEBI:17821

metaR DAG HSter
kinetic law: MODEL1310110040#
name: diacylglycerol ER export
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110040#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1770c3bf_3139_409d_b9a7_075d50a77166
is: SBO:0000252
has only substance units: false
name: TUSC3
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7991

metaR r2104
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_3c4659c8_b669_4987_b327_e1395d38af5b
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6584
initial amount: NaN
name: SLC22A5
boundary condition: true
has only substance units: false
constant: false
is: O76082

http://identifiers.org/biomodels.db/MODEL1310110040#_29facb7d_b83b_4b09_84db_91af009c1d9f
is: SBO:0000252
boundary condition: true
name: SLC6A9
type: Species
is encoded by: hsa:6536
initial concentration: NaN
has only substance units: false
constant: false
is: B7Z3W8
initial amount: NaN

metaM glutcoa m
name: glutaryl-CoA(5-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
has only substance units: false
type: Species
is: CHEBI:57378
is: HMDB01339
constant: false
initial amount: NaN

metaR FAOXC141C141OHm
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR ASPDt6
name: D-aspartate transport via Na, H symport and K antiport
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
kinetic law: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction

metaR r0999
name: Facilitated diffusion
kinetic law: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
reversible: true
product: MODEL1310110040#

metaR NACHEX9ly
is: SBO:0000176
reversible: false
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110040#
product: MODEL1310110040#

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: true
modifier: MODEL1310110040#

metaR GGH 10FTHF5GLUe
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000

metaM cholate r
is: CHEBI:29747
initial concentration: 1.0
name: cholate
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
is: HMDB00619
is: SBO:0000247

metaR C161CPT2
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_21d56ed2_2f3f_4d2b_9f96_1413a0a72d86
is: SBO:0000252
has only substance units: false
is: B2RB13
boundary condition: true
initial concentration: NaN
name: ACSL6
initial amount: NaN
constant: false
is encoded by: hsa:23305
type: Species

metaR PGDI
is: SBO:0000176
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.5.1.18
product: MODEL1310110040#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/5.3.99.2
type: Reaction
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
modifier: MODEL1310110040#
name: Prostaglandin-H2 D-isomerase [Precursor]
fast: false

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR It
is described by: ECO:0000269
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110040#
name: Iodide uniport
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110040#

metaR DURAD2
name: dihydrothymin dehydrogenase (NADP)
modifier: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#
product: MODEL1310110040#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reactant: MODEL1310110040#

metaM 6dhf e
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial amount: NaN
name: hexaglutamyl folate (DHF)
boundary condition: false
constant: false
is: HMDB06563
is: SBO:0000247

metaR C161CPT1
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
is described by: ECO:0000000
name: production of palmitoleoylcarnitine
is: SBO:0000176
type: Reaction
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_dd714673_197d_4b18_8848_7c146c789b8f
boundary condition: true
is: B3KT86
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:109
name: ADCY3
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR BAAT2x
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#
fast: false
name: bile acid Coenzyme A: amino acid N-acyltransferase

metaR S23T4g
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
type: Reaction
reversible: false

metaR r2356
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_4399d1ee_4c9e_43eb_898c_d2869f3d2b09
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:U37519
is: SBO:0000252
type: Species
boundary condition: true
name: _U37519_1_m

metaM frdp c
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:175763
type: Species
initial amount: NaN
name: Farnesyl diphosphate
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
is: HMDB00961
is: C00448

metaM pyr x
constant: false
is: CHEBI:15361
name: pyruvate
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00243
is: C00022
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_e7309a4c_1e02_45d3_8366_1a707fcb4add
is: P08319
constant: false
name: ADH4
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:127
boundary condition: true
has only substance units: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM arachdcrn m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01322
boundary condition: false
constant: false
type: Species
is: CHEBI:57387
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine

http://identifiers.org/biomodels.db/MODEL1310110040#_51630f7b_c1d8_47d2_8cdd_5bc6bab34789
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000297
has part: Q6NZ59
constant: false
initial amount: NaN
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d842011a_797d_4a8a_9394_27e5491bbdd5
is: SBO:0000252
initial amount: NaN
name: NME2
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4831
initial concentration: NaN
has only substance units: false
is: P22392

metaR r2357
is: SBO:0000185
product: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110040#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_f0345400_705b_43b1_b7f1_41d19e1e3ff7
has only substance units: false
name: AMY2B
is: P19961
type: Species
boundary condition: true
constant: false
is encoded by: hsa:280
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM lnlncg r
is: HMDB03073
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
name: gamma-linolenate
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
initial amount: NaN

metaM ppcoa m
name: Propanoyl-CoA
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01275
type: Species
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247
is: C00100
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_4b842289_f872_4c1b_b85f_27615b106cc3
is: SBO:0000252
is encoded by: hsa:92483
is: Q9BYZ2
initial amount: NaN
type: Species
name: LDHAL6B
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_98ceab7a_f457_4524_aefb_406f39e05721
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10965
has only substance units: false
is: P49753
name: ACOT2
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR GLYCK2
is described by: ECO:0000000
reversible: false
name: glycerate kinase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
type: Reaction
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_de4741e7_1e05_4b1c_b9fe_b324e234ad6a
name: SLC17A5
is: SBO:0000252
is: Q9NRA2
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:26503
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_08c038b4_7825_4ec5_8837_34beddff45d6
boundary condition: true
name: _AI435857_1_x
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI435857
initial concentration: NaN
constant: false

metaR HEXDICOAACBP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaM gm3 hs g
initial concentration: 1.0
constant: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: CHEBI:60065
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730

metaR LPASE
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
name: lysophospholipase
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.5

metaR RE3000M
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: RE3000
type: Reaction
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110040#
reversible: true

metaR r2108
reactant: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110040#
reversible: true
fast: false
modifier: MODEL1310110040#

metaR INSt
kinetic law: MODEL1310110040#
is described by: ECO:0000269
product: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
reversible: true
modifier: MODEL1310110040#
is: SBO:0000185
name: Inosine transport (diffusion)
reactant: MODEL1310110040#
fast: false

metaM dcsptn1crn m
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
has only substance units: false

metaM acmana c
name: N-acetyl-D-mannosamine
is: HMDB01129
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17122
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false

metaR r2354
reactant: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
product: MODEL1310110040#

metaR IDOAASE3ly
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false

metaR TDCHOLAtx
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
fast: false
name: bile acid intracellular transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaM 5hoxindoa c
has only substance units: false
is: CHEBI:27823
initial concentration: 1.0
boundary condition: false
name: 5-Hydroxyindoleacetate
is: HMDB00763
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
type: Species

metaM ksii core4 pre2 g
is: HMDB00175
initial amount: NaN
has only substance units: false
is: C00130
constant: false
is: CHEBI:58053
name: keratan sulfate II boisynthesis, precursor 2
type: Species
notes: FORMULA: C47H76N4O33X CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM m1mpdol L c
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
has only substance units: false
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
constant: false
type: Species

metaM icit c
type: Species
is: CHEBI:16087
is: HMDB00193
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
is: SBO:0000247
boundary condition: false
name: Isocitrate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8f8cb291_bb16_46b1_8cb7_a2a6d31bc88e
name: MAN1A1
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P33908
boundary condition: true
is encoded by: hsa:4121
has only substance units: false
type: Species

metaR RE1532M
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
name: RE1532
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110040#

metaR CHOLATEt
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000269
name: cholate transport via bicarbonate countertransport

metaM dcdp c
is: C00705
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
name: dCDP
is: HMDB01245
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:58593
initial concentration: 1.0
is: SBO:0000247

metaR ACITL
modifier: MODEL1310110040#
fast: false
name: ATP-Citrate lyase
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.3.8
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is: SBO:0000176

metaR r2109
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110040#

metaR RE0577C
fast: false
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000000
name: RE0577
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_0e5686eb_7311_42cd_a538_9b2a642977b3
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: HK1
type: Species
is: P19367
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3098

metaR EX dca LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Decanoate (n-C10:0) exchange
type: Reaction

metaR THRGLNexR
reactant: MODEL1310110040#
name: L-threonine/glycine reversible exchange
fast: false
kinetic law: MODEL1310110040#
is described by: ECO:0000304
product: MODEL1310110040#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110040#

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
reversible: true
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110040#

metaM retfa c
is: CHEBI:50211
initial concentration: 1.0
initial amount: NaN
name: fatty acid retinol
type: Species
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: HMDB00305
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaR ACNAMPH
reactant: MODEL1310110040#
reversible: false
kinetic law: MODEL1310110040#
fast: false
is described by: ECO:0000000
type: Reaction
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110040#

metaR B3GALT43g
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 4
reversible: false
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.62
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_6c0fca4f_9f1c_4b23_827f_4a0e82a961cf
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P46459
has only substance units: false
constant: false
name: NSF
is encoded by: hsa:4905
type: Species
initial amount: NaN

metaR r1620
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR C141CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaM thym c
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:17821
is: C00178
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00262
name: Thymine

http://identifiers.org/biomodels.db/MODEL1310110040#_1ea36f6b_937f_4a2a_85b3_39ffa10ee309
initial amount: NaN
name: ENTPD8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:377841
is: Q5MY95
constant: false
has only substance units: false

metaR CGLYt3 2
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
product: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
name: Cys-Gly transport in via proton symport
is: SBO:0000185
type: Reaction
reversible: false

metaM cytd e
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
initial concentration: 1.0
boundary condition: false
is: CHEBI:17562
initial amount: NaN
name: Cytidine
is: HMDB00089
has only substance units: false

metaR ACGALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
name: N-acetyl-galactosamine lysosomal efflux
is: SBO:0000185
type: Reaction
reversible: false
fast: false

metaR r0437
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110040#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false

metaR MTHFC
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: MODEL1310110040#
name: methenyltetrahydrofolate cyclohydrolase
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_c7b7af17_c512_4405_8036_d69649b18a17
initial amount: NaN
type: Species
name: AMY1A
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: Q6NSB3
initial concentration: NaN
is encoded by: hsa:276

http://identifiers.org/biomodels.db/MODEL1310110040#_64d6ff28_42b2_4a2a_bca1_1d96bafd5e8a
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P07451
is encoded by: hsa:761
initial concentration: NaN
name: CA3

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
fast: false
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
product: MODEL1310110040#

metaM 7dhf e
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
name: heptaglutamyl folate (DHF)
type: Species
constant: false
is: HMDB06559
initial concentration: 1.0

metaM icit m
constant: false
is: HMDB00193
is: SBO:0000247
is: CHEBI:16087
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
type: Species
name: Isocitrate
is: C00311
has only substance units: false
initial concentration: 1.0

metaR UMPK2n
reactant: MODEL1310110040#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#
name: UMP kinase (CTP),nuclear

metaR C81CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR r0242
reversible: true
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.2.1.1

metaM cs e deg2 l
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
initial concentration: 1.0
type: Species
is: HMDB01354
is: CHEBI:57455

metaR P4501B1r
name: cytochrome P450 1B1
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.14.1
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_a23c4a97_b255_466d_9c4c_a64b3b20af47
is: P14672
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:6517
is: SBO:0000252
initial concentration: NaN
name: SLC2A4
type: Species
initial amount: NaN

metaM xoldiolone c
boundary condition: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB02197
is: CHEBI:28477
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_953a0823_b85e_4a93_9efb_cd4708fb5e07
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4540
is: P03915
name: ND5
constant: false

metaR S6TASE19ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
kinetic law: MODEL1310110040#
fast: false
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
modifier: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_c8d04e27_1def_4d59_851c_e3fd9e66eebd
type: Species
is: Q86U05
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:23428
initial concentration: NaN
constant: false
name: SLC7A8

metaR C226CRNt
type: Reaction
is described by: ECO:0000000
name: C226 transport into the mitochondria
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: false
reactant: MODEL1310110040#

metaM ptdcacoa c
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB06499
initial concentration: 1.0
type: Species
constant: false
name: pentadecanoyl Coenzyme A
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_1b3d62a1_fbac_4848_acbf_987ed0d156b9
initial concentration: NaN
name: SULT1A1
is: P50225
initial amount: NaN
type: Species
is encoded by: hsa:6817
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_9f87834a_c189_4058_be2b_eeecd025510c
is: SBO:0000252
initial concentration: NaN
name: ALG3
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:10195

metaM thym e
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17821
type: Species
initial amount: NaN
name: thymine
has only substance units: false
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262
constant: false

metaM cytd c
boundary condition: false
initial concentration: 1.0
name: Cytidine
is: HMDB00089
is: CHEBI:17562
has only substance units: false
is: C00475
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_e3a46b0d_1b89_41b7_98bf_c60f4a11a0ca
is encoded by: hsa:2027
initial concentration: NaN
name: ENO3
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: D3DTL2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5065205f_010e_47d7_b97a_436edeb15948
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P16885
is encoded by: hsa:5336
type: Species
name: PLCG2
initial amount: NaN

metaM f6p c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3385
name: D-Fructose 6-phosphate
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: C00085
has only substance units: false
is: CHEBI:57579
is: HMDB00124

metaR HEXDCRNe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR RE1521M
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1521
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110040#
type: Reaction
reversible: true
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176

metaM 7dhf c
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: HMDB06559
name: heptaglutamyl folate (DHF)
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM m2gacpail hs r
constant: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
is: SBO:0000247
boundary condition: false
is: CHEBI:16038
has only substance units: false
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_f2c7e4e8_67a5_4790_8a98_0444f485af44
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4594
name: MUT
constant: false
initial amount: NaN
is: P22033

metaR MTHFD
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is: SBO:0000176
modifier: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110040#
name: methylenetetrahydrofolate dehydrogenase (NADP)

metaM ala L m
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16977
is: HMDB00161
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM 6dhf l
boundary condition: false
has only substance units: false
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
constant: false
initial concentration: 1.0
is: HMDB06563
type: Species
is: SBO:0000247
initial amount: NaN

metaR P4508B11r
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.95
type: Reaction
is: SBO:0000176
name: sterol 12-alpha-hydroxylase
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
product: MODEL1310110040#
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false
reversible: false

metaM stcrn c
has only substance units: false
initial amount: NaN
is: HMDB00848
type: Species
constant: false
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
boundary condition: false
name: stearoylcarnitine
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_2823f89a_72d1_4399_a278_6b657a0c68e6
initial amount: NaN
type: Species
name: ABAT
is: SBO:0000252
constant: false
is encoded by: hsa:18
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR MM8Cg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
product: MODEL1310110040#
is: SBO:0000176

metaR r0245
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
type: Reaction
modifier: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reversible: true

metaR FRUt4
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
name: D-fructose transport via sodium cotransport
kinetic law: MODEL1310110040#
reversible: true
product: MODEL1310110040#
type: Reaction
modifier: MODEL1310110040#

metaM ppcoa x
type: Species
has only substance units: false
is: HMDB01275
initial concentration: 1.0
is: CHEBI:57392
is: C00100
name: Propanoyl-CoA
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN

metaR GLYCtm
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
name: glycerol transport
kinetic law: MODEL1310110040#
product: MODEL1310110040#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_a1fd36aa_a911_43a3_9da5_aca498ab2581
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GPX1
type: Species
is: P07203
is encoded by: hsa:2876
initial amount: NaN
constant: false

metaR r1624
kinetic law: MODEL1310110040#
reversible: true
modifier: MODEL1310110040#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM CE5786 e
type: Species
is: CHEBI:27485
boundary condition: false
has only substance units: false
is: HMDB02710
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: kinetensin

metaM glc D e
has only substance units: false
is: CHEBI:4167
type: Species
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
initial concentration: 1.0
is: HMDB00122
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_405a4482_68d0_44f8_8c09_7655ea516d4a
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
initial concentration: NaN
constant: false
name: _HG2846_HT2983_1_c
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR APOCFm
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
name: Apocarboxylase formation, mitochondrial
reactant: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism

metaM 6dhf m
boundary condition: false
initial amount: NaN
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06563
type: Species
name: hexaglutamyl folate (DHF)

metaR r0647
kinetic law: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reactant: MODEL1310110040#
product: MODEL1310110040#
is: SBO:0000176
name: Spontaneous reaction
is described by: ECO:0000000
type: Reaction
reversible: true

metaM zymstnl r
type: Species
initial concentration: 1.0
is: CHEBI:16608
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
constant: false
name: 5alpha-cholest-8-en-3beta-ol
has only substance units: false
is: HMDB06841
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR PTDCACRNCPT2
reversible: false
is: SBO:0000176
name: pentadecanoate transport into the mitochondria
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reversible: true
product: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#

metaR r0246
is described by: ECO:0000000
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3

http://identifiers.org/biomodels.db/MODEL1310110040#_7420d137_4e86_4d65_aae5_ed6005a1d2cd
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q6IBB5
constant: false
is encoded by: hsa:4694
name: NDUFA1
type: Species

metaR MMMm
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
is described by: ECO:0000269
name: methylmalonyl-CoA mutase
product: MODEL1310110040#
is: SBO:0000176
reactant: MODEL1310110040#

metaM Lcyst c
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
is: HMDB02757
is: SBO:0000247
name: L-cysteate(1-)
initial amount: NaN
type: Species
constant: false
is: CHEBI:58090
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_8d8133be_e442_4450_a5e6_f5e854c99a0c
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PANK1
has only substance units: false
type: Species
constant: false
is encoded by: hsa:53354

http://identifiers.org/biomodels.db/MODEL1310110040#_d082c9ef_d769_4792_a24b_906e9431e9a2
type: Species
has only substance units: false
initial concentration: NaN
is: B7Z792
constant: false
initial amount: NaN
name: NDUFS2
is: SBO:0000252
is encoded by: hsa:4720
boundary condition: true

metaM mi145p c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
has only substance units: false
is: HMDB01498
constant: false
type: Species
is: CHEBI:203600

metaR r0434
fast: false
product: MODEL1310110040#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_746a98a6_548d_4815_bb6c_d78fae928e88
has part: C9JPQ8
type: Species
has part: P05166
initial amount: NaN
has only substance units: false
is: SBO:0000297
constant: false
name: PCCA:PCCB
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5095
is encoded by: hsa:5096

http://identifiers.org/biomodels.db/MODEL1310110040#_6f9b66f1_3d99_4dc4_b12f_6a32d50ec5a2
name: B3GNT6
is: SBO:0000252
is: A8K9Q8
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:192134
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_fd96abe4_0bb2_429b_a7da_10b95d4e735b
initial amount: NaN
initial concentration: NaN
name: GALNT10
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:55568
type: Species

metaR r0321
type: Reaction
fast: false
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/6.3.5.2
reversible: false
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_1ba49222_68f9_4487_9d92_50df69f324fd
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC24A3
is encoded by: hsa:57419
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: Q9HC58

metaM hs deg2 l
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
has only substance units: false
name: heparan sulfate, degradation product 2
is: HMDB06254
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d7a460db_33d2_4405_897b_9c6d7f8feded
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: AGXT2L1
type: Species
is encoded by: hsa:64850
initial concentration: NaN
boundary condition: true
is: Q8TBG4

metaR PTDCACRNCPT1
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
product: MODEL1310110040#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110040#
name: carnitine fatty-acyl transferase
reversible: false
is described by: ECO:0000269
fast: false

metaR GGH 5THFe
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110040#
name: Gamma-glutamyl hydrolase (5THF), extracellular
reversible: false
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110040#

metaR r1622
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaR r0021
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110040#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110040#
product: MODEL1310110040#

metaM damp c
initial concentration: 1.0
constant: false
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: HMDB00905
is: SBO:0000247
initial amount: NaN
name: dAMP(2-)
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_af2729f1_16e7_4d3a_a17f_0c2a76c289be
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4047
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: E9PEI9
name: LSS

metaM glc D c
has only substance units: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
is: CHEBI:4167
type: Species
initial concentration: 1.0
is: HMDB00122
initial amount: NaN
is: SBO:0000247
constant: false

metaR CORE3GTg
fast: false
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110040#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000
type: Reaction

metaM g3p c
name: Glyceraldehyde 3-phosphate
is: SBO:0000247
is: HMDB01112
is: CHEBI:58027
is: C00661
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: http://identifiers.org/pubchem.compound/3930
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_8bc5b4d8_34c7_4868_9633_c0759abcdb02
constant: false
is encoded by: hsa:883
name: CCBL1
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: Q16773
initial concentration: NaN
is: SBO:0000252

metaR r1621
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
product: MODEL1310110040#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0022
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_00af545f_3a5f_4fd3_bfdc_ceeeb38358af
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: STS
is: P08842
is encoded by: hsa:412
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_21cbcde4_9fc9_4077_9063_f85a2c7ef609
boundary condition: true
initial amount: NaN
name: ACAA2
is encoded by: hsa:10449
is: SBO:0000252
constant: false
is: P42765
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_00285360_9d9c_4d7a_96a0_49066f2b1e13
is encoded by: hsa:55350
has only substance units: false
has part: O95498
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_538f5145_2839_4cd4_8875_3caa3aacf4bd
is: P09960
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4048
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: LTA4H

metaR PNTK
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110040#
modifier: MODEL1310110040#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110040#
name: pantothenate kinase
is described by: ECO:0000269
product: MODEL1310110040#
fast: false
type: Reaction

metaM arachdcrn c
is: CHEBI:57387
initial amount: NaN
initial concentration: 1.0
name: C20:4 carnitine
type: Species
constant: false
is: HMDB01322
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR GALASE4ly
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
type: Reaction
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
name: beta-galactosidase, lysosomal

metaR S6T6g
modifier: MODEL1310110040#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110040#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110040#_b9a1a0ef_34a9_4882_8a2b_1fb74cc326ce
is: Q92947
type: Species
is encoded by: hsa:2639
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GCDH

metaM hexdiac c
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00672
initial concentration: 1.0
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
is: SBO:0000247
type: Species
name: hexadecanediocacid
constant: false

metaR MALSO4tm
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
name: Malate:sulfate antiport, mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

metaR r0656
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
type: Reaction
fast: false
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_4133bf69_a12a_4915_bb53_2058146c536d
type: Species
constant: false
has only substance units: false
is encoded by: hsa:2588
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: GALNS
boundary condition: true
is: P34059

metaR RE1709C
reversible: true
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
name: RE1709
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_7f0ec8dd_aa46_47cd_b357_63ee9d9b88d1
type: Species
initial amount: NaN
is: P17568
is: SBO:0000252
is encoded by: hsa:4713
name: NDUFB7
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR MI1P Dtn
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
name: inositol 1-phosphate nuclear transport (diffusion)

metaM pan4p e
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: HMDB01416
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:47942
name: Pantetheine 4'-phosphate
is: C01134
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaR Coqe
fast: false
is: SBO:0000185
kinetic law: MODEL1310110040#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of q10
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#

metaR r1615
modifier: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_df082398_79c7_4722_8696_f9cbb07186f0
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6818
name: SULT1A3
is: SBO:0000252
type: Species
is: P50224
constant: false
boundary condition: true

metaR ACSm
is described by: ECO:0000304
product: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
name: acetyl-CoA synthetase
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
type: Reaction
fast: false
reversible: false

metaM inost e
boundary condition: false
is: HMDB00211
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17268
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
name: myo-inositol

http://identifiers.org/biomodels.db/MODEL1310110040#_77cfd146_7c92_49fd_92df_1be152cb5197
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:3423
has only substance units: false
is: P22304
initial amount: NaN
name: IDS
is: SBO:0000252

metaM amp m
constant: false
name: AMP(2-)
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
is: CHEBI:456215
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00045
has only substance units: false

metaR r1401
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/3.2.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.51
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.10.1
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Facilitated diffusion
product: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.1.3

metaM 7dhf m
initial amount: NaN
has only substance units: false
name: heptaglutamyl folate (DHF)
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: HMDB06559

http://identifiers.org/biomodels.db/MODEL1310110040#_c7bb1640_1a30_494d_8096_8db9e16dc753
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9NWU1
has only substance units: false
initial concentration: NaN
name: OXSM
constant: false
is encoded by: hsa:54995
type: Species

metaM m2mn l
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06537
type: Species
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine

metaM c6crn c
notes: FORMULA: C13H25NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: hexanoyl carnitine
constant: false
is: HMDB00705
has only substance units: false

metaM pyr m
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
name: pyruvate
is: CHEBI:15361
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
is: C00022
constant: false
has only substance units: false
is: HMDB00243
is: SBO:0000247
type: Species
boundary condition: false

metaR CYTK1
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP)
reversible: true
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#

metaR r0655
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
modifier: MODEL1310110040#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
type: Reaction
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_13b065e3_039e_4ef6_b136_6e79ba3e0bab
is: P49753
is encoded by: hsa:10965
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ACOT2
constant: false
type: Species

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM cholate c
initial amount: NaN
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: CHEBI:29747
initial concentration: 1.0
name: Cholate
has only substance units: false
constant: false
is: HMDB00619
boundary condition: false
type: Species
is: SBO:0000247

metaR S6T12g
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110040#

metaR r1616
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a05f243b_d8e8_4890_ac8a_d97db6c2a4d4
is encoded by: hsa:54995
initial amount: NaN
has only substance units: false
is: Q9NWU1
constant: false
type: Species
initial concentration: NaN
name: OXSM
is: SBO:0000252
boundary condition: true

metaR EX 3octdeccrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaR PYDXtr
is described by: ECO:0000000
fast: false
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
name: Pyridoxal transport
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
reversible: true

metaR LYStip
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false
name: L-lysine transport, peroxisomal (irreversible)

metaM lnlncg e
constant: false
boundary condition: false
type: Species
name: gamma-linolenate
is: HMDB03073
initial amount: NaN
is: CHEBI:32391
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247

metaM pan4p c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: C01134
boundary condition: false
is: HMDB01416
initial concentration: 1.0
name: Pantetheine 4'-phosphate
type: Species
is: CHEBI:47942
constant: false

metaR IPDDIx
name: isopentenyl-diphosphate D-isomerase
is: SBO:0000176
reversible: true
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/5.3.3.2
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false

metaM C02470 c
boundary condition: false
constant: false
is: HMDB00881
has only substance units: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5485
type: Species
is: C02470
initial concentration: 1.0
is: SBO:0000247
name: Xanthurenic acid

http://identifiers.org/biomodels.db/MODEL1310110040#_07c0cfe1_f173_43cb_a0e0_050bb77d9038
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:80201
type: Species
initial amount: NaN
is: SBO:0000252
is: B3KT70
name: HKDC1

metaM s2l2fn2m2masn e
boundary condition: false
type: Species
name: PA6
is: HMDB00244
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: CHEBI:3554
is: C00255
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaM inost c
boundary condition: false
constant: false
has only substance units: false
is: HMDB00211
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
type: Species
name: myo-inositol

metaR FUCASEe
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000000
product: MODEL1310110040#
fast: false
name: alpha-fucosidase, extracellular
kinetic law: MODEL1310110040#

metaR r1613
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_e8116b71_51eb_4588_b117_b734e1fac6af
is: B4DX94
boundary condition: true
initial amount: NaN
name: PGM3
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5238
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_2dc4626f_b7b7_4f26_b1ed_b0779377bc55
name: TXNRD1
has only substance units: false
type: Species
is: Q16881
is: SBO:0000252
is encoded by: hsa:7296
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaM CE4872 m
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00127
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: CHEBI:15748
initial concentration: 1.0

metaM c6crn e
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
name: hexanoyl carnitine
is: HMDB00705
boundary condition: false
type: Species

metaR GDPFUCtg
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
type: Reaction
product: MODEL1310110040#
fast: false
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
name: GDPFuc Golgi transport via CMP antiport
is described by: ECO:0000269

metaR CO2ter
product: MODEL1310110040#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: CO2 endoplasmic reticular transport via diffusion
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_95e3b090_3bd5_42c8_9a82_4a8dbbbc17b7
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:AI990637
initial concentration: NaN
name: _AI990637_1_x
constant: false
boundary condition: true

metaM fad m
is: HMDB01248
constant: false
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
is: CHEBI:16238
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR EICOSTETCPT2
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: carnitine transferase
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_dda50491_ad55_4659_aa31_530749d467c7
is encoded by: hsa:AI926493
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: _AI926493_1_m

http://identifiers.org/biomodels.db/MODEL1310110040#_6984d96a_e0d1_469a_941a_05885a3ff775
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4191
constant: false
is: P40926
is: SBO:0000252
name: MDH2
initial concentration: NaN

metaR r0653
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110040#
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110040#

metaR NP1
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
name: nucleotide phosphatase
reactant: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110040#
reversible: false
type: Reaction
is described by: ECO:0000304

metaM 3tetd7ecoa c
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: HMDB05066
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
boundary condition: false

metaM stcrn m
name: stearoylcarnitine
initial amount: NaN
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: HMDB00848
boundary condition: false

metaR r1614
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
fast: false

metaM lnlncg c
boundary condition: false
name: gamma-linolenate
is: SBO:0000247
type: Species
constant: false
is: HMDB03073
is: CHEBI:32391
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0

metaM 7dhf l
constant: false
name: heptaglutamyl folate (DHF)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
is: HMDB06559
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_08dc6e91_29b8_4ff5_b6a0_9a856914c6a2
name: DGKI
initial amount: NaN
is encoded by: hsa:9162
is: SBO:0000252
type: Species
boundary condition: true
is: O75912
has only substance units: false
initial concentration: NaN
constant: false

metaR r0652
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
product: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM ksii core2 g
has only substance units: false
name: keratan sulfate II (core 2-linked)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00189
constant: false
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57614
type: Species

metaR C162OHe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaR EICOSTETCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine O-palmitoyltransferase
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false

metaR CYTK4
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
type: Reaction
product: MODEL1310110040#
reversible: true
name: cytidylate kinase (dCMP)(GTP)
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is: SBO:0000176
fast: false

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110040#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
name: Glutamine transport (Na, H coupled)
product: MODEL1310110040#

metaR C141OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
type: Species
is: CHEBI:57917
constant: false
is: HMDB01232
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 4-nitrophenolate

metaM dolp L r
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: dolichyl phosphate(2-)
is: CHEBI:57683
initial amount: NaN

metaM 42A3HP24DB c
boundary condition: false
has only substance units: false
is: HMDB04083
type: Species
is: http://identifiers.org/pubchem.compound/7956
constant: false
is: SBO:0000247
is: C05645
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
initial concentration: 1.0
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial amount: NaN

metaR 3SALAASPm
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
reactant: MODEL1310110040#
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: cysteinesulfinate-aspartate mitochondrial shuttle
fast: false
modifier: MODEL1310110040#
reversible: true

metaR r1619
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110040#
reversible: true
reactant: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction

metaR CYTK5
type: Reaction
name: cytidylate kinase (dCMP)
fast: false
product: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110040#_59c6d1b0_f1a3_486d_9617_a3da6653666a
initial amount: NaN
initial concentration: NaN
is: Q96AS2
name: ASAH1
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:427
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_ba3431f2_eba4_4f40_a511_8c06ebb528a0
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:2542
is: A8K0S7
name: SLC37A4
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r0027
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
modifier: MODEL1310110040#
fast: false
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
is: SBO:0000176

metaR HSPGtly
is: SBO:0000185
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: heparan sulfate transport, extracellular to lysosome
product: MODEL1310110040#
reversible: false
fast: false
reactant: MODEL1310110040#

metaR C141OHe
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR TDCHOLAte
name: bile acid intracellular transport
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110040#

metaR URIt5le
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000134
fast: false
reversible: false
name: uridine transport in via sodium symport (1:2)
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaR C162OHc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR RE1517M
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
name: RE1517
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaR r0650
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
modifier: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM ksi pre28 g
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 28
is: C00130

metaM ksii core2 e
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
constant: false
initial concentration: 1.0
is: HMDB00211
name: keratan sulfate II (core 2-linked)
is: CHEBI:17268
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_80a55806_a860_4f98_9d24_e4d6b3219b16
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9BW60
boundary condition: true
has only substance units: false
name: ELOVL1
is encoded by: hsa:64834
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_bb2560e9_d679_441e_8529_bd447119a203
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5092
name: PCBD1
is: P61457
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5fd3779c_ff6e_44fe_9113_7837e69545b7
constant: false
boundary condition: true
is: P15289
has only substance units: false
type: Species
initial concentration: NaN
name: ARSA
initial amount: NaN
is encoded by: hsa:410
is: SBO:0000252

metaR CYTK2
name: cytidylate kinase (dCMP)
product: MODEL1310110040#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110040#_44cfab38_08f3_4f18_a655_26ef180cc421
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10797
type: Species
constant: false
is: P13995
has only substance units: false
is: SBO:0000252
name: MTHFD2

http://identifiers.org/biomodels.db/MODEL1310110040#_0d489db6_11a2_4196_94b4_6d4f33b2ba7a
type: Species
name: DLAT:DLD:PDHA2:PDHB:PDHX
is: SBO:0000297
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5162
has part: Q86YI5
boundary condition: true
has part: P29803
is encoded by: hsa:1737
constant: false
has part: P11177
is encoded by: hsa:5161

metaR r1617
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110040#
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#

metaM ksi pre9 g
name: keratan sulfate I biosynthesis, precursor 9
constant: false
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00175
boundary condition: false
is: C00130
has only substance units: false
notes: FORMULA: C121H196N8O93S2X CHARGE: -3

metaM frdp r
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
name: Farnesyl diphosphate
is: CHEBI:175763
initial amount: NaN
has only substance units: false
is: HMDB00961
is: C00448
type: Species

metaR GLUt2m
fast: false
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
product: MODEL1310110040#
is described by: ECO:0000269
name: L-glutamate reversible transport via proton symport, mitochondrial
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true

metaR CYTK3
reversible: true
name: cytidylate kinase (CMP)(GTP)
fast: false
type: Reaction
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110040#

metaR ASPte
is: SBO:0000185
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
is described by: ECO:0000134
reactant: MODEL1310110040#
name: diffusion of aspartate into blood
type: Reaction
kinetic law: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_83b18c9d_4e4f_41df_9fc5_56b2c517c87d
is: P37287
name: PIGA
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5277
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r1618
product: MODEL1310110040#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction

metaR G14T6g
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR ASCBt4
kinetic law: MODEL1310110040#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110040#
name: L-ascorbate transport via proton symport
modifier: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_8b089857_8a30_4dec_9778_5291ac396782
initial amount: NaN
is: O43772
boundary condition: true
has only substance units: false
name: SLC25A20
type: Species
is encoded by: hsa:788
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110040#_9a37ee47_a3ad_4d94_b4aa_ec2f4c392996
is: Q9HCR9
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:50940
name: PDE11A
is: SBO:0000252

metaM HC02121 c
is: CHEBI:58758
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: S-(hydroxymethyl)glutathione(1-)
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR CRNtim
product: MODEL1310110040#
modifier: MODEL1310110040#
name: L-carnitine transport out of mitochondria via diffusion
reversible: false
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110040#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110040#

metaM HC01408 m
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:27648
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
name: 3-Oxohexanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110040#_2adbc46a_42d1_4f96_abec_617ed2579301
constant: false
is: SBO:0000252
is: Q99707
initial concentration: NaN
name: MTR
initial amount: NaN
is encoded by: hsa:4548
has only substance units: false
type: Species
boundary condition: true

metaM C05279 m
boundary condition: false
is: HMDB11123
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
has only substance units: false
is: CHEBI:28387
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_958dfe6a_bcf2_4e51_b757_e3aa2e09e3d8
initial concentration: NaN
name: IDH2
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: P48735
is encoded by: hsa:3418
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_fdd7ff39_44cb_47a8_ad1e_59472c15d1d7
has part: P08195
is encoded by: hsa:56301
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:6520
has part: Q9NS82
has only substance units: false
is: SBO:0000297
boundary condition: true
initial amount: NaN
name: SLC7A10:SLC3A2

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_2116a2d3_f44a_4c31_a9b4_306e5868455b
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:375056
name: MIA3
has only substance units: false
initial concentration: NaN
is: Q5JRA6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_cdb28a53_5081_4c53_b203_aef38d0f17d7
is: P10619
is: SBO:0000252
is encoded by: hsa:5476
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: CTSA
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_8a59535d_6672_4327_846d_4bb77a44c49e
initial concentration: NaN
is: B4DFS7
name: FUT8
constant: false
initial amount: NaN
is encoded by: hsa:2530
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM frdp x
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00961
name: farnesyl pyrophosphate(3-)
constant: false
initial concentration: 1.0
type: Species

metaM CE4872 c
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: HMDB00127
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_4d06af5d_6118_4ed1_b772_9a1403a7340a
is: Q71UM8
name: ADCY2
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:108
initial concentration: NaN

metaR OCT11EFATP
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_10dcd040_926b_4b1c_b9cb_bfd2def128ee
type: Species
initial concentration: NaN
is: SBO:0000252
name: ND2
has only substance units: false
is: Q7GXY9
is encoded by: hsa:4536
boundary condition: true
constant: false
initial amount: NaN

metaM C04849 e
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110040#_acd0fbd3_0c3b_4617_84c2_e7e9b40f6298
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:U52111
type: Species
has only substance units: false
name: _U52111_1_c
initial amount: NaN

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_c139efea_168d_4a72_b9b9_0d665c150187
has only substance units: false
is encoded by: hsa:AA576959
type: Species
name: _AA576959_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_f34040eb_436d_491f_84ff_4f68a6dfb14d
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: A0N0X8
initial concentration: NaN
is encoded by: hsa:1543
type: Species
name: CYP1A1
initial amount: NaN

metaR EX 4pyrdx LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Pyridoxate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1a7ec89f_249e_4141_86ea_3cb5d3e6c52d
boundary condition: true
initial amount: NaN
constant: false
is: Q1EHB4
is encoded by: hsa:159963
initial concentration: NaN
name: SLC5A12
is: SBO:0000252
has only substance units: false
type: Species

metaM lnlncg l
is: SBO:0000247
is: CHEBI:32391
type: Species
name: gamma-linolenate
initial concentration: 1.0
boundary condition: false
is: HMDB03073
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426

metaR r2359
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110040#
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_135ac686_3975_4f25_bd87_c54a845eeab4
is encoded by: hsa:2878
has only substance units: false
boundary condition: true
name: GPX3
is: P22352
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_a1c1430e_f15e_46be_8ce6_56e78ce1f8e7
is: SBO:0000252
constant: false
is: Q99714
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3028
has only substance units: false
name: HSD17B10
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110040#_b16ba96c_4283_4cfe_b307_fd313f13c221
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: PLCB1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23236

http://identifiers.org/biomodels.db/MODEL1310110040#_c39ef4cb_04f0_4b41_a32c_b6b30d6b2fa0
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: FDPS
type: Species
constant: false
has only substance units: false
is: P14324
is encoded by: hsa:2224
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_b280f277_f623_40aa_8f57_7717606e4e88
constant: false
initial amount: NaN
type: Species
name: ACHE
is: P22303
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:43
boundary condition: true

metaR NACHEX23ly
kinetic law: MODEL1310110040#
reversible: false
is: SBO:0000176
reactant: MODEL1310110040#
is described by: ECO:0000000
modifier: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM 4nph c
is: CHEBI:57917
boundary condition: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
is: HMDB01232
initial concentration: 1.0
is: SBO:0000247
name: 4-nitrophenolate
has only substance units: false
type: Species
constant: false

metaR r0541
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
fast: false
reactant: MODEL1310110040#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR UDPGALtg
fast: false
is described by: ECO:0000269
modifier: MODEL1310110040#
product: MODEL1310110040#
type: Reaction
name: UDP-Gal Golgi transport via CMP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_2355bd35_8662_453e_a5fe_8f38dd11945d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: ALDOB
is: P05062
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:229

metaM 3tetd7ecoa m
name: 3-hydroxy tetradecenoyl-7-coa
type: Species
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB05066
boundary condition: false
constant: false

metaR NADtx
kinetic law: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: transport of NAD into peroxisome
type: Reaction
reversible: true
reactant: MODEL1310110040#
fast: false

metaR r2358
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
kinetic law: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
type: Reaction

metaM fad e
is: SBO:0000247
is: HMDB01248
is: C00016
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: CHEBI:16238
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_28d165d9_151a_4ece_bca9_4b104aea5c6f
initial amount: NaN
type: Species
is encoded by: hsa:5332
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: E2QRH8
has only substance units: false
name: PLCB4

http://identifiers.org/biomodels.db/MODEL1310110040#_b5d03afc_e777_4cd2_8000_4b02858dc0a8
initial concentration: NaN
is: Q96QG2
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC8A3
is encoded by: hsa:6547
boundary condition: true

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaM mi134p c
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01143
has only substance units: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false
is: CHEBI:58414

metaR 4HPRO LTte
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110040#
name: Transport of trans-4-hydroxy-L-proline
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_97508323_dd81_4392_92da_ac1564240ed3
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:498
has part: B4DY56
type: Species
is: SBO:0000297
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaM amp x
is: C00020
constant: false
name: AMP
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00045
is: CHEBI:456215
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110040#_c1aaff72_b326_4142_aa7a_f730232a899c
name: SLC27A1
type: Species
is encoded by: hsa:376497
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r2103
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110040#
product: MODEL1310110040#
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_d8557fd5_e77c_42a8_967d_d1ddf6e84e6c
is: Q6LEN5
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: CHAT

metaM ksii core4 pre9 g
name: keratan sulfate II biosynthesis, precursor 9
initial concentration: 1.0
has only substance units: false
is: CHEBI:28067
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR THYOXt2
modifier: MODEL1310110040#
type: Reaction
is described by: ECO:0000269
name: T4 transport via facilitated diffusion
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
reversible: true
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

metaR HPDCACRNt
name: heptadecanoate transport into the mitochondria
kinetic law: MODEL1310110040#
fast: false
product: MODEL1310110040#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
is described by: ECO:0000269
is: SBO:0000185

metaM dcdp m
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:58593
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
name: dCDP(3-)
is: HMDB01245
has only substance units: false

metaR HSPASEly
reactant: MODEL1310110040#
reversible: false
fast: false
name: heparan sulfate proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110040#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_d222c253_0f6b_4965_a96b_6f70b23ef69d
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2653
is: P23434
name: GCSH

metaR DOLMANP Lter
product: MODEL1310110040#
is: SBO:0000185
kinetic law: MODEL1310110040#
name: dolichol-phosphate mannose flippase (liver)
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110040#
is described by: ECO:0000000
fast: false

metaR r0547
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
product: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_0f950cdf_e2bb_4b03_af67_5e3ab3290e4c
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5052
name: PRDX1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3539cac4_a8d5_40cb_9543_b46cf7e4cea1
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PEMT
type: Species
boundary condition: true
is encoded by: hsa:10400
constant: false

http://identifiers.org/biomodels.db/MODEL1310110040#_cb72cd60_7273_47d2_9bd7_beee64758b38
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5052
boundary condition: true
name: PRDX1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_39fa05f8_81f7_42af_a894_96e323682514
is: SBO:0000252
is encoded by: hsa:51733
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: UPB1
is: B3KNC1
constant: false
initial concentration: NaN

metaR r2102
modifier: MODEL1310110040#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110040#
is: SBO:0000185
product: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR FACOAL2251
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110040#
type: Reaction
fast: false
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110040#
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_88162f7a_5c0f_40ff_959d_3a030b9e38c4
boundary condition: true
initial amount: NaN
is encoded by: hsa:5372
is: SBO:0000252
initial concentration: NaN
name: PMM1
is: A8K003
constant: false
has only substance units: false
type: Species

metaR S2TASE3ly
kinetic law: MODEL1310110040#
product: MODEL1310110040#
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
name: iduronate-2-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.13
reversible: false
reactant: MODEL1310110040#

metaM hexdiac r
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: hexadecanediocacid
initial amount: NaN
notes: FORMULA: C16H28O4 CHARGE: -2
is: C08260
has only substance units: false
boundary condition: false
is: HMDB00672

metaR NMNtn
reversible: true
name: NMN transport, nuclear trhough pore
is described by: ECO:0000000
product: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM dcdp n
boundary condition: false
name: dCDP(3-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58593
is: HMDB01245
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM amp r
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
boundary condition: false
name: AMP
type: Species
is: C00020
initial concentration: 1.0
has only substance units: false
is: HMDB00045
initial amount: NaN
is: CHEBI:456215

metaR ALADGLNexR
is: SBO:0000185
reactant: MODEL1310110040#
is described by: ECO:0000304
modifier: MODEL1310110040#
reversible: true
name: L-alanine/glutamine reversible exchange
fast: false
type: Reaction
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110040#

metaM pram c
is: SBO:0000247
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
type: Species
is: HMDB01128
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:58681
has only substance units: false
name: 5-Phospho-beta-D-ribosylamine
is: C03090

metaR FAOXC5C5DCc
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR r2101
reversible: true
fast: false
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110040#_14dac033_65e4_4037_a69c_5303ebceac1b
has only substance units: false
is: O43820
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: HYAL3
is: SBO:0000252
is encoded by: hsa:8372

metaR ILETA
fast: false
reactant: MODEL1310110040#
is: SBO:0000176
reversible: true
product: MODEL1310110040#
name: isoleucine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
modifier: MODEL1310110040#
is described by: ECO:0000269
kinetic law: MODEL1310110040#

metaR r0545
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
modifier: MODEL1310110040#
reversible: true
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
product: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR PRFGS
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110040#
fast: false
name: phosphoribosylformylglycinamidine synthase
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.3
is described by: ECO:0000269
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110040#_ab8a600d_c033_46bf_b271_2258b5488c79
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PYCR2
initial concentration: NaN
type: Species
is encoded by: hsa:29920
is: Q96C36
constant: false

metaR PI345P5P
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
fast: false
reactant: MODEL1310110040#
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_93abf367_65aa_4205_acc8_3105d08a0d02
boundary condition: true
is: Q8TEQ8
is: SBO:0000252
is encoded by: hsa:84720
name: PIGO
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaM cholate e
has only substance units: false
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
is: HMDB00619
initial amount: NaN
name: Cholate
is: SBO:0000247
boundary condition: false
is: CHEBI:29747
initial concentration: 1.0

metaR r2100
modifier: MODEL1310110040#
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110040#
is: SBO:0000185
fast: false

metaM 25hvitd2 m
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C28H44O2 CHARGE: 0 INCHI: InChI=1/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25?,26+,28-/m1/s1
is: HMDB01438
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 25-Hydroxyvitamin D2

metaR DUTPDPn
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
type: Reaction
kinetic law: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.6.1.23
name: dUTP diphosphatase, nuclear
is described by: ECO:0000269
reactant: MODEL1310110040#
reversible: false
product: MODEL1310110040#
fast: false
modifier: MODEL1310110040#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110040#_6feee14e_8fb4_4437_91a0_d5cae3a628dd
initial amount: NaN
type: Species
is encoded by: hsa:10599
is: Q9Y6L6
constant: false
has only substance units: false
boundary condition: true
name: SLCO1B1
is: SBO:0000252
initial concentration: NaN

metaM ksii core2 l
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: keratan sulfate II (core 2-linked)
is: HMDB00189
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
constant: false
is: CHEBI:57614

metaR RE1709N
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
name: RE1709
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110040#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_192956fe_c0fe_42bf_9f28_d04948c99177
is encoded by: hsa:5860
boundary condition: true
initial amount: NaN
is: P09417
name: QDPR
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM elaidcrn m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB06464
name: Elaidic carnitine

http://identifiers.org/biomodels.db/MODEL1310110040#_61a0e3ca_c3d5_4303_8e81_25883d7825db
is: O95498
is: SBO:0000252
type: Species
is encoded by: hsa:8875
name: VNN2
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR DAGKn hs
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110040#
name: Diacylglycerol phosphate kinase (homo sapiens)
fast: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110040#
kinetic law: MODEL1310110040#
is described by: ECO:0000269

metaR GLCt4
product: MODEL1310110040#
name: glucose transport via sodium symport
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
reversible: true

metaM cyan e
has only substance units: false
initial amount: NaN
type: Species
is: HMDB02084
boundary condition: false
constant: false
name: hydrogen cyanide
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407

http://identifiers.org/biomodels.db/MODEL1310110040#_6476b419_aaab_4430_936a_60c56210a0fe
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: BAAT
is: Q14032
initial concentration: NaN
constant: false
is encoded by: hsa:570

metaR C120CPT1
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR DGULND
type: Reaction
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110040#
name: dehydro-L-gulonate decarboxylase
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110040#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110040#_7b5d0e4b_a24f_4bb9_bfdc_2ef7a037dbc8
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P20020
has only substance units: false
name: ATP2B1
is encoded by: hsa:490

metaM 5fthf m
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57457
is: HMDB01562
has only substance units: false
type: Species
name: 5-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479

metaR r2116
fast: false
product: MODEL1310110040#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110040#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110040#
reversible: true

metaM dcsptn1 e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB13123
has only substance units: false
type: Species
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: docosa-4,7,10,13,16-pentaenoic acid

metaR 3SALAOX
name: cysteinesulfinic acid oxidase
reversible: false
product: MODEL1310110040#
type: Reaction
kinetic law: MODEL1310110040#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
reactant: MODEL1310110040#

metaR DOLPGT2 Ler
product: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
modifier: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.265
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
reversible: false
kinetic law: MODEL1310110040#
is: SBO:0000176
is described by: ECO:0000000

metaM dhap e
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: glycerone phosphate(2-)
constant: false
initial amount: NaN
is: HMDB01473
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: CHEBI:57642

metaR r0549
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
product: MODEL1310110040#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
modifier: MODEL1310110040#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction

metaM udp r
is: SBO:0000247
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
initial amount: NaN
name: UDP
has only substance units: false
is: HMDB00295
is: C00015
boundary condition: false
is: CHEBI:58223
initial concentration: 1.0

metaR EX ivcrn
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_b8756d8c_9717_4702_a0b7_5c2259f5245e
initial concentration: NaN
is: Q9NUB1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:84532
has only substance units: false
type: Species
constant: false
name: ACSS1

metaR GLCNACASE3ly
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110040#
modifier: MODEL1310110040#
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50

metaM m4mpdol L r
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:37633
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
type: Species
boundary condition: false

metaR r2117
kinetic law: MODEL1310110040#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110040#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110040#
fast: false

metaR ST6GALNAC27
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.7
product: MODEL1310110040#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110040#
modifier: MODEL1310110040#
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
reactant: MODEL1310110040#

metaR FAOXC181C161m
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reactant: MODEL1310110040#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR FAOXC170m
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
reversible: false
product: MODEL1310110040#
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110040#
name: Beta oxidation of long chain fatty acid (odd chain)
modifier: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_a98d7db3_91aa_4095_9eee_0595fe984ce7
constant: false
type: Species
boundary condition: true
name: LDHC
initial concentration: NaN
is encoded by: hsa:3948
has only substance units: false
initial amount: NaN
is: P07864
is: SBO:0000252

metaM cyan c
constant: false
name: hydrogen cyanide
initial amount: NaN
is: HMDB02084
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
type: Species
is: CHEBI:18407

metaR RE3001M
modifier: MODEL1310110040#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
reversible: true
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
reactant: MODEL1310110040#
fast: false
type: Reaction
name: RE3001
kinetic law: MODEL1310110040#
product: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_ae729275_5a91_4f4d_8393_dfc80267a644
constant: false
is: SBO:0000252
initial concentration: NaN
is: B7Z6Q4
boundary condition: true
type: Species
is encoded by: hsa:3612
initial amount: NaN
has only substance units: false
name: IMPA1

metaR r2118
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
modifier: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110040#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110040#_462ec11e_ac13_433a_ba46_9709c854eabe
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:11332
name: ACOT7
is: SBO:0000252
is: O00154
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_3f75d854_4b0d_42c6_b4d4_435cc71aa91e
has part: Q9BRB3
initial concentration: NaN
is encoded by: hsa:5279
type: Species
is encoded by: hsa:8818
initial amount: NaN
has only substance units: false
is encoded by: hsa:5283
has part: Q92535
is encoded by: hsa:9091
is encoded by: hsa:51227
boundary condition: true
is: SBO:0000297
has part: B3KUV7
has part: Q14442
constant: false
has part: O94777
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5277

metaM glu L e
has only substance units: false
is: CHEBI:29985
is: HMDB00148
initial concentration: 1.0
boundary condition: false
type: Species
name: L-glutamate(1-)
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
is: SBO:0000247

metaR r2341
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110040#
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110040#

metaR PSSA1 hs
modifier: MODEL1310110040#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is: SBO:0000176
name: Phosphatidylserine synthase homo sapiens
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110040#
product: MODEL1310110040#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29
reactant: MODEL1310110040#

metaM dhap c
is: http://identifiers.org/pubchem.compound/3411
constant: false
is: HMDB01473
initial concentration: 1.0
is: C00111
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57642
has only substance units: false
name: Dihydroxyacetone phosphate

metaM ksi deg21 l
constant: false
name: keratan sulfate I, degradation product 21
initial amount: NaN
has only substance units: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
type: Species
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
is: HMDB00143
initial concentration: 1.0

metaR r2119
is: SBO:0000185
reactant: MODEL1310110040#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110040#
product: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true

metaR PNTOte
product: MODEL1310110040#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of (R)-Pantothenate
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
reversible: true

metaR DM hretn n
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4 hydroxy retinoic acid demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_1376534f_d9c0_483d_8b00_c27fda4a64eb
initial amount: NaN
constant: false
is encoded by: hsa:2584
initial concentration: NaN
has only substance units: false
is: P51570
type: Species
name: GALK1
boundary condition: true
is: SBO:0000252

metaM 3mob m
boundary condition: false
is: SBO:0000247
is: HMDB00019
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851

metaM tmndnccrn m
is: HMDB12130
constant: false
initial concentration: 1.0
is: CHEBI:16987
name: Timnodonyl carnitine
initial amount: NaN
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110040#_3d0c99ee_269a_4fbb_8791_e2f4830e721a
type: Species
is: SBO:0000252
name: PDE8A
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5151
is: H0YMZ7

metaM 25hvitd2 e
initial amount: NaN
name: 25-Hydroxyvitamin D2
has only substance units: false
boundary condition: false
constant: false
is: HMDB01438
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C28H44O2 CHARGE: 0 INCHI: InChI=1/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25?,26+,28-/m1/s1

metaR EX gd1c hs LPAREN e RPAREN
kinetic law: MODEL1310110040#
reactant: MODEL1310110040#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GD1c (homo sapiens) exchange
type: Reaction

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.22
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110040#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110040#
is described by: ECO:0000000
reactant: MODEL1310110040#
is version of: http://identifiers.org/ec-code/3.1.2.2
modifier: MODEL1310110040#

metaR PGCD
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
name: phosphoglycerate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.95
kinetic law: MODEL1310110040#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
type: Reaction
reactant: MODEL1310110040#
fast: false
is: SBO:0000176

metaM glu L c
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: L-glutamate(1-)
is: HMDB00148
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110040#_8f787866_a7bc_4c8f_9246_186f8fbd91dc
has only substance units: false
boundary condition: true
is encoded by: hsa:56901
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFA4L2
constant: false
is: Q9NRX3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_680ae25d_c378_44b3_901c_3294209bd72e
constant: false
name: HADHA
is: E9KL44
is encoded by: hsa:3030
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species

metaM e4p c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00279
is: CHEBI:16897
is: HMDB01321
has only substance units: false
boundary condition: false
type: Species
constant: false
name: D-Erythrose 4-phosphate
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279

metaM malttr e
boundary condition: false
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: SBO:0000247
is: CHEBI:27931
initial concentration: 1.0
type: Species
is: HMDB01262
constant: false
is: C01835
initial amount: NaN
name: maltotriose

metaR THYOXt
type: Reaction
name: T4 transport via bicarbonate countertransport
modifier: MODEL1310110040#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
product: MODEL1310110040#
is: SBO:0000185
reactant: MODEL1310110040#
kinetic law: MODEL1310110040#
reversible: true

metaM h2o e
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
initial amount: NaN
name: H2O
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB02111
boundary condition: false

metaR RETI1
name: retinol isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110040#
reversible: true
type: Reaction
product: MODEL1310110040#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110040#

http://identifiers.org/biomodels.db/MODEL1310110040#_2f35be29_61c5_4a17_9b52_84f34eef716e
initial concentration: NaN
constant: false
name: ACP2
is: SBO:0000252
type: Species
initial amount: NaN
is: E9PCI1
is encoded by: hsa:53
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110040#_5a546711_695b_4cd3_8b75_3a34e292328c
is encoded by: hsa:LOC374569
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _LOC374569_1_e

http://identifiers.org/biomodels.db/MODEL1310110040#_9b1f93b8_011b_4ee9_9196_cd2a321fa2b3
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: EHHADH
is encoded by: hsa:1962
is: Q9NY65
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_88302743_685f_4e80_8375_be56b193ed8c
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56953
name: NT5M
constant: false
is: Q9NPB1
boundary condition: true

metaM phytcoa c
is: HMDB01359
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: phytanoyl-CoA(4-)
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_42251666_cfca_4b64_b95c_ed01d870de6d
type: Species
name: GALNT8
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: Q9NY28
initial amount: NaN
is encoded by: hsa:26290

http://identifiers.org/biomodels.db/MODEL1310110040#_633d00d2_bdc9_4e40_8348_a5723d565c22
has only substance units: false
initial concentration: NaN
name: DGUOK
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:1716
type: Species
is: Q16854
initial amount: NaN

metaR C204CRNt
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
product: MODEL1310110040#
kinetic law: MODEL1310110040#
type: Reaction
reactant: MODEL1310110040#
is: SBO:0000185
name: arachidonic acid transport into the mitochondria
reversible: false

metaM dcyt n
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
constant: false
name: 2'-deoxycytidine
is: HMDB00014
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15698
initial concentration: 1.0

metaM prostgd2 c
name: prostaglandin D2(1-)
is: CHEBI:57406
is: SBO:0000247
constant: false
is: HMDB01403
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110040#_217cb508_6a2b_41e5_ad07_5d915332743f
type: Species
name: ACAT1
is: SBO:0000252
initial amount: NaN
constant: false
is: P24752
boundary condition: true
initial concentration: NaN
is encoded by: hsa:38
has only substance units: false

metaR r2344
reversible: true
product: MODEL1310110040#
reactant: MODEL1310110040#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110040#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaM CE4792 m
is: CHEBI:15748
constant: false
initial amount: NaN
name: 3-oxo-cis-8-tetradecenoyl-CoA
boundary condition: false
is: HMDB00127
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species

metaM 25hvitd2 c
name: 25-Hydroxyvitamin D2
initial amount: NaN
constant: false
notes: FORMULA: C28H44O2 CHARGE: 0 INCHI: InChI=1/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25?,26+,28-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01438
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110040#_d81b47df_24aa_4f52_999f_4e55b0a91d68
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: UPP2
has only substance units: false
is encoded by: hsa:151531
is: O95045
type: Species

http://identifiers.org/biomodels.db/MODEL1310110040#_2976b338_d476_49d1_b846_2c16ea544815
boundary condition: true
constant: false
is encoded by: hsa:3158
type: Species
is: SBO:0000252
is: P54868
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: HMGCS2

metaR ST8SIA55g
reactant: MODEL1310110040#
name: Beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176
kinetic law: MODEL1310110040#
type: Reaction
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110040#
product: MODEL1310110040#
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110040#_7dbd9b98_0758_4971_8666_4831ee71b112
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR NACHEX3ly
type: Reaction
product: MODEL1310110040#
reactant: MODEL1310110040#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110040#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110040#
reversible: false