metaR HSAT3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110039#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000

metaR RE3627M
type: Reaction
fast: false
is described by: ECO:0000000
name: RE3627
reactant: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_9858c5ed_2deb_4c97_8a39_a0530ed43737
is: A0PJH2
constant: false
name: ATP5H
initial concentration: NaN
is encoded by: hsa:10476
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_3aea46e2_4722_43f3_bbce_99d2fb3b8023
has part: P55084
initial amount: NaN
is encoded by: hsa:3030
name: HADHA:HADHB
is encoded by: hsa:3032
constant: false
is: SBO:0000297
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
has part: E9KL44

metaR RE1807M
modifier: MODEL1310110039#
fast: false
name: RE1807
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR BDMT U
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.142
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
product: MODEL1310110039#
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
type: Species
boundary condition: false
name: adrenyl coenzyme A
initial concentration: 1.0
has only substance units: false

metaM ksi deg41 l
initial amount: NaN
is: HMDB00143
notes: FORMULA: C34H58N2O26 CHARGE: 0
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 41
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
has only substance units: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR r2080
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#

metaR F1PGT
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.30
kinetic law: MODEL1310110039#
name: fucose-1-phosphate guanylyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true

metaM xoldioloneh c
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:2288
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: SBO:0000247
constant: false
is: HMDB06887
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_aad44fda_c9d7_4773_b3af_a37c87d9cfd3
is: A7E2E0
initial amount: NaN
name: PIK3CD
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5293
constant: false
initial concentration: NaN
has only substance units: false

metaM dhcholestanate x
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16577
is: SBO:0000247
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_4212c4fd_115d_4164_8247_70420a5fc646
initial concentration: NaN
constant: false
is encoded by: hsa:6647
type: Species
boundary condition: true
initial amount: NaN
is: P00441
is: SBO:0000252
has only substance units: false
name: SOD1

metaM imp c
is: C00130
is: SBO:0000247
name: IMP
constant: false
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaM HC00250 c
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
type: Species
name: hydrosulfide
boundary condition: false
constant: false
is: CHEBI:29919
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR DNDPt35m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110039#
type: Reaction
reversible: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
name: dGDP transport via dADP antiport
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_33b6276d_c5d0_4740_be23_e4250374875f
has only substance units: false
type: Species
boundary condition: true
is: P11166
initial amount: NaN
is encoded by: hsa:6513
name: SLC2A1
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_7979fd76_9613_4df6_9d2d_c4c781c5dc4e
type: Species
initial amount: NaN
boundary condition: true
is: B7Z763
name: AMPD3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:272

metaR RPEc
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110039#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#

metaR CORE2GTg
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
reversible: false
modifier: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.102

metaM lnlnca e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
is: HMDB01388
boundary condition: false
initial concentration: 1.0
name: alpha-linolenate
has only substance units: false
is: CHEBI:32387
is: SBO:0000247
constant: false
initial amount: NaN

metaM val L e
constant: false
initial amount: NaN
name: L-valine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16414
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883

metaR r0940
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110039#_27ffac3a_dca9_4e6d_b3bb_8d7d3cf840b9
is: Q96DU7
initial amount: NaN
name: ITPKC
is encoded by: hsa:80271
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species

metaM ksi pre32 g
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
constant: false
name: keratan sulfate I biosynthesis, precursor 32
is: CHEBI:28067
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_cae6da59_106a_40a4_97d7_dc0ce5170282
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:100287639
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _100287639_1_c

metaR ANTHte
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000134
reversible: true
fast: false
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_83385634_89ed_492b_b34c_7036ff6a609b
is: SBO:0000252
type: Species
is encoded by: hsa:6532
name: SLC6A4
constant: false
boundary condition: true
initial amount: NaN
is: P31645
has only substance units: false
initial concentration: NaN

metaM 5forthf c
initial amount: NaN
is: SBO:0000247
is: HMDB01534
name: 5-Formiminotetrahydrofolate
constant: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: CHEBI:57456
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00664
type: Species

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR NACHEX11ly
type: Reaction
reactant: MODEL1310110039#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#

metaR ASNtN1
reversible: true
type: Reaction
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
kinetic law: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#

metaM r5p c
has only substance units: false
is: C00117
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial amount: NaN
is: CHEBI:18189
boundary condition: false
is: HMDB00618
constant: false
name: alpha-D-Ribose 5-phosphate

metaR r2083
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM 3mlda e
is: SBO:0000247
constant: false
name: 3-Methylimidazoleacetic acid
type: Species
initial concentration: 1.0
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: C05828
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB02820
is: http://identifiers.org/pubchem.compound/8122

metaR r2082
product: MODEL1310110039#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110039#

metaM ksi deg11 l
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB00143
has only substance units: false
is: CHEBI:12936
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
name: keratan sulfate I, degradation product 11

metaR IDOAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.76
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: alpha-L-iduronidase, lysosomal
reversible: false
product: MODEL1310110039#
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_6bf5c357_cd5c_481d_ad45_71b69cb61f15
name: RHBG
initial amount: NaN
is encoded by: hsa:57127
initial concentration: NaN
is: Q9H310
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_9522e1e7_f43a_4c53_9c3e_4489e36a835f
is encoded by: hsa:79369
is: SBO:0000252
name: B3GNT4
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q9C0J1
constant: false
has only substance units: false

metaM xol7ah2al c
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR FAOXC165C164x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM HC00250 e
name: hydrosulfide
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
type: Species
is: CHEBI:29919
has only substance units: false
initial concentration: 1.0

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR AICARte
is described by: ECO:0000134
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM oaa c
constant: false
is: CHEBI:3338
is: SBO:0000247
initial concentration: 1.0
name: Oxaloacetate
boundary condition: false
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2
has only substance units: false
is: C00036
is: HMDB00223
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_76bbc10d_bef3_49ef_a680_689cb0ae619e
is: O00757
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: FBP2
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:8789

http://identifiers.org/biomodels.db/MODEL1310110039#_392fea46_de9a_4012_9de1_032c82c083aa
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFC2
is encoded by: hsa:4718
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q549M5

metaM glyald c
name: D-Glyceraldehyde
is: SBO:0000247
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01051
type: Species
initial amount: NaN
is: C00577
is: CHEBI:17378

http://identifiers.org/biomodels.db/MODEL1310110039#_1ad372d3_d29c_4db1_834f_b1a1b708a069
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54539
initial amount: NaN
is: Q9NX14
name: NDUFB11
has only substance units: false

metaM uacgam r
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
is: SBO:0000247
is: CHEBI:57705
initial concentration: 1.0

metaR r2081
is: SBO:0000185
fast: false
product: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true

metaM hs deg14 l
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
initial amount: NaN
is: SBO:0000247
name: heparan sulfate, degradation product 14
has only substance units: false
is: HMDB00127
is: CHEBI:15748
initial concentration: 1.0
type: Species
boundary condition: false

metaM dctp n
initial concentration: 1.0
is: C00458
is: SBO:0000247
boundary condition: false
is: HMDB00998
type: Species
is: CHEBI:16311
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
name: dCTP
constant: false

metaM 2decdicoa m
name: 2,7-decadienoylcoa
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaM lnlnca c
initial amount: NaN
type: Species
name: alpha-linolenate
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01388
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_6da57f80_6059_40a2_9ba5_551c8763dd5f
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3295
is: E9PB82
is: SBO:0000252
constant: false
name: HSD17B4
type: Species

metaR L LACt4r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
name: L-lactate reversible transport via sodium symport
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_84c6643a_de8f_4b22_a21a_824376b30a45
is: Q9Y617
name: PSAT1
initial amount: NaN
is encoded by: hsa:29968
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM 44mzym r
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: SBO:0000247
is: HMDB01286
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18364
name: 14-demethyllanosterol
has only substance units: false
boundary condition: false
type: Species

metaM nh4 e
has only substance units: false
name: ammonium
is: HMDB00051
type: Species
is: CHEBI:28938
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR FAOXC164m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_5202d0df_c180_4ca6_a6f9_ee31828d6c3e
boundary condition: true
is: Q96AT9
initial concentration: NaN
name: RPE
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6120

http://identifiers.org/biomodels.db/MODEL1310110039#_712dc824_0c84_40fd_a19a_3a6645f70275
initial amount: NaN
is encoded by: hsa:3948
has only substance units: false
type: Species
is: SBO:0000252
is: P07864
initial concentration: NaN
name: LDHC
boundary condition: true
constant: false

metaR FAOXC201C181x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR GALASE16ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110039#
reversible: false
product: MODEL1310110039#
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM HC01672 c
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
has only substance units: false
name: Acetyl adenylate
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:37666
type: Species
is: SBO:0000247
initial amount: NaN

metaM ura e
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00300
initial amount: NaN
name: uracil
constant: false
is: CHEBI:17568
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false

metaM cs e l
initial concentration: 1.0
is: HMDB02183
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
constant: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
type: Species
is: CHEBI:36005
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM ptdcacrn m
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
constant: false
is: HMDB01721
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15811
initial concentration: 1.0
name: pendtadenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110039#_9d733c33_1d9d_486e_83fe_632519d50d34
initial amount: NaN
is: P50336
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5498
initial concentration: NaN
type: Species
name: PPOX

metaR HYXNt
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000269
name: Hypoxanthine transport
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
fast: false

metaR D3AIBTm
is described by: ECO:0000000
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_e2e446dd_b591_4cc4_b53a_70c1f6b2ed37
is: P35475
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:3425
constant: false
initial amount: NaN
name: IDUA
is: SBO:0000252

metaR BILDGLCURt
modifier: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
type: Reaction
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
fast: false

metaR ACt2m
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
kinetic law: MODEL1310110039#
fast: false
name: acetate mitochondrial transport via proton symport
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_cf95e3d4_ad23_46e6_b7f1_72ee4c650f18
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:10400
has only substance units: false
name: PEMT
type: Species
is: SBO:0000252

metaM nh4 c
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
constant: false
is: C01342
has only substance units: false
is: SBO:0000247
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
name: Ammonium
type: Species

metaR FAOXC164GC163m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_01e4c1b8_23fe_4891_8a17_f634e88acfe4
name: INPP1
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:3628
type: Species
is: SBO:0000252
is: P49441

http://identifiers.org/biomodels.db/MODEL1310110039#_2cbfbd66_ef01_4871_b2e1_afbe1997670c
has only substance units: false
name: ACO1
is: P21399
constant: false
is encoded by: hsa:48
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR SEBCOACROT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaM pro D e
boundary condition: false
is: CHEBI:16313
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB03411

http://identifiers.org/biomodels.db/MODEL1310110039#_c42a00d2_2a85_41fd_a316_042d218ab8a7
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:10587
name: TXNRD2
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9NNW7
constant: false

metaR THRALANaEx
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is described by: ECO:0000269
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)

http://identifiers.org/biomodels.db/MODEL1310110039#_2245730d_08f2_4026_ba2a_f3d31350fe38
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:R14373
name: _R14373_1_x
constant: false

metaR DOLASNT Uer
fast: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.119
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110039#
reversible: false
type: Reaction
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110039#_07e3b762_11e5_40a7_90ab_a65c973e98f5
has only substance units: false
is encoded by: hsa:65010
is: SBO:0000252
name: SLC26A6
initial concentration: NaN
constant: false
is: Q548A7
type: Species
initial amount: NaN
boundary condition: true

metaM m2mpdol U c
boundary condition: false
has only substance units: false
is: CHEBI:28049
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
constant: false

metaM ura c
initial concentration: 1.0
name: Uracil
boundary condition: false
type: Species
is: C00106
is: HMDB00300
is: CHEBI:17568
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: SBO:0000247

metaR S4TASE1ly
kinetic law: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_67e3766c_4eeb_4ce9_9d48_bf1c8699aad5
boundary condition: true
is encoded by: hsa:64834
is: Q9BW60
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: ELOVL1

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM c4crn m
is: SBO:0000247
is: HMDB02013
initial amount: NaN
has only substance units: false
boundary condition: false
is: C02862
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
constant: false

metaR SIAASE3ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
type: Reaction
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
fast: false

metaM ksi deg17 l
constant: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 17
boundary condition: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
has only substance units: false
type: Species

metaM hs deg6 l
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01352
is: CHEBI:17180
initial concentration: 1.0
name: heparan sulfate, degradation product 6
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_550d5e04_7b0d_4fcb_a58f_1ee43a216a9c
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q6LEN5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
boundary condition: true

metaM tetpent3 e
is: HMDB06323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
name: tetracosapentaenoic acid, n-3
initial amount: NaN

metaM thr L e
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
name: L-threonine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00167
type: Species
has only substance units: false
constant: false
is: CHEBI:16857

http://identifiers.org/biomodels.db/MODEL1310110039#_2d938ac6_2f5d_4cb0_8fa3_d1ffc8acd049
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:125206
is: A0PJK1
name: SLC5A10
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaR r1629
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM tettet6coa x
constant: false
is: C16171
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: tetracosatetraenoyl coenzyme A
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205481
is: HMDB06516
type: Species

metaR IDPtn
reversible: true
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: IDP nuclear transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_cb3a6d75_3034_49a3_846b_26df0b8630d7
is encoded by: hsa:34
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P11310
name: ACADM
type: Species
initial amount: NaN
constant: false

metaM asp L e
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: L-aspartate(1-)
is: CHEBI:29991

metaR ORNDC
reversible: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
name: Ornithine Decarboxylase
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.1.1.17

metaR UDPACGALtl
type: Reaction
fast: false
is described by: ECO:0000000
name: udpacgal intracellular transport
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_61e97922_b67a_4ad4_b7d4_abfd3ecf616b
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: F5H6D0
is encoded by: hsa:7841
is: SBO:0000252
boundary condition: true
constant: false
name: MOGS

metaR ECOAH1m
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110039#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e895200f_b801_4a3a_98ec_ead7bf0f5e34
is: F8WAB8
is encoded by: hsa:115286
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC25A26
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a7308034_6aac_4823_bee0_4c7e4982058e
is: Q6IB80
type: Species
has only substance units: false
is: SBO:0000252
name: NDUFB3
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4709
initial amount: NaN

metaR RE1807C
name: RE1807
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR ACACT10m
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_9d50cf1a_3330_4bf9_8945_6068afa6200d
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:498
type: Species
initial concentration: NaN
is: P25705
constant: false
initial amount: NaN
name: ATP5A1

metaR GHMT2r
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.1
type: Reaction
kinetic law: MODEL1310110039#
name: glycine hydroxymethyltransferase, reversible
is: SBO:0000176
reactant: MODEL1310110039#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
product: MODEL1310110039#
modifier: MODEL1310110039#

metaR r1628
reversible: true
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
fast: false

metaR CO2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
name: CO2 transport (diffusion), mitochondrial
is described by: ECO:0000000
type: Reaction

metaM thcholoylcoa x
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
constant: false
is: CHEBI:27403
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB12456
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_85dfca39_bd54_43d1_b03f_e7e3c95c8833
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: ND4L
is encoded by: hsa:4539
is: Q7GXZ4
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR HDD2COAtx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
name: hdd2coa intracellular transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_38945910_8169_42ca_8885_c3c99595f5b5
is encoded by: hsa:341947
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q7Z4L0
initial amount: NaN
name: COX8C
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_fefc0635_d2a1_4ce9_8fd0_0ce855f317f9
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: NDUFA4
is: O00483
is encoded by: hsa:4697
initial concentration: NaN
boundary condition: true

metaM gam6p c
is: CHEBI:12962
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01254
name: D-Glucosamine 6-phosphate
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352

metaM fadh2 x
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58307
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB01197
boundary condition: false
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaR RETI2
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol isomerase (9-cis)
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true
fast: false

metaR r1627
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_20afde10_3b13_44fc_b987_14e2a0e8bb5f
is: SBO:0000252
has only substance units: false
is: Q70HW3
initial concentration: NaN
is encoded by: hsa:115286
initial amount: NaN
type: Species
constant: false
name: SLC25A26
boundary condition: true

metaM HC02023 r
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: CHEBI:46898
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: Cholesterol-ester-ol

metaM tetpent3 c
is: HMDB06323
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: tetracosapentaenoic acid, n-3
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false
has only substance units: false
type: Species
constant: false

metaM CE1935 e
is: HMDB02329
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
initial amount: NaN
is: CHEBI:30623
name: spermine monoaldehyde
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_90b3d9ee_5527_4582_8d98_b0fe30896d41
has only substance units: false
type: Species
name: _AL048840_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AL048840
constant: false

metaM HC01377 m
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
is: SBO:0000247
has only substance units: false
is: CHEBI:27462
constant: false
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide

metaM asp L c
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: L-aspartate(1-)
is: HMDB00191
is: SBO:0000247
is: CHEBI:29991
constant: false

metaM ksi deg25 l
is: SBO:0000247
name: keratan sulfate I, degradation product 25
initial concentration: 1.0
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: HMDB01354
constant: false
type: Species
initial amount: NaN
is: CHEBI:57455
boundary condition: false
has only substance units: false

metaM thr L c
name: L-threonine
boundary condition: false
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
is: CHEBI:16857
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_75039211_471c_4261_9587_6e5aed57de3a
constant: false
is: SBO:0000252
initial amount: NaN
name: GGCT
initial concentration: NaN
is: B8ZZR8
has only substance units: false
is encoded by: hsa:79017
boundary condition: true
type: Species

metaM Rtotal2coa c
initial amount: NaN
is: HMDB01564
constant: false
is: SBO:0000247
is: CHEBI:57876
name: R total 2 coenzyme A
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110039#_b9196c24_434b_4c81_ad58_062f2a9566ec
name: ZADH2
is: SBO:0000252
constant: false
has only substance units: false
is: Q8N4Q0
type: Species
initial amount: NaN
is encoded by: hsa:284273
initial concentration: NaN
boundary condition: true

metaR HPDCACRNt
reversible: false
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
name: heptadecanoate transport into the mitochondria
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_669368e4_242c_430b_99a9_ec546a78c10d
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PLCB4
is encoded by: hsa:5332
has only substance units: false
type: Species
initial concentration: NaN
is: E2QRH8

metaR r0946
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
fast: false
reversible: true

metaM adrncoa m
is: C16170
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
name: adrenyl coenzyme A
constant: false

metaR TYRt
reactant: MODEL1310110039#
name: L-tyrosine transport
reversible: true
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
modifier: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
type: Reaction
fast: false

metaR r1626
modifier: MODEL1310110039#
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
fast: false
type: Reaction
reversible: true

metaR ACt2r
name: acetate reversible transport via proton symport
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_12484934_12b5_47cb_a4f2_72e9f11b6332
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI539321
boundary condition: true
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110039#_a66eba22_442f_49d2_99c8_ff6f84928a80
name: PAPSS1
has only substance units: false
initial amount: NaN
is: O43252
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:9061
initial concentration: NaN
boundary condition: true

metaR r1625
is: SBO:0000185
reactant: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110039#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM so4 m
boundary condition: false
name: sulfate
constant: false
type: Species
has only substance units: false
is: HMDB01448
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: CHEBI:16189
initial amount: NaN

metaR CYTK1
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
name: cytidylate kinase (CMP)
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 3mlda c
is: C05828
initial concentration: 1.0
is: HMDB02820
is: http://identifiers.org/pubchem.compound/8122
constant: false
name: 3-Methylimidazoleacetic acid
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
has only substance units: false
is: SBO:0000247

metaM CE2839 e
has only substance units: false
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
is: C01936
type: Species
boundary condition: false
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
initial concentration: 1.0

metaM nh4 m
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Ammonium
constant: false
initial amount: NaN
is: CHEBI:28938
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: C01342

metaM psylchol e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/94244
type: Species
name: psillium-glycocholic acid complex
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_3f751fe2_b763_4ce2_82bf_bbdb4f8a20e4
is encoded by: hsa:5333
constant: false
is: SBO:0000252
has only substance units: false
is: P51178
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: PLCD1

metaM 3php c
type: Species
is: HMDB01024
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: CHEBI:18110
constant: false
name: 3-phosphonatooxypyruvate(3-)

metaM 3ddcrn c
is: HMDB00623
initial concentration: 1.0
notes: FORMULA: C19H37NO5 CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: 3-hydroxydodecanoylcarnitine

metaR CO2tp
name: CO2 peroxisomal transport
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true

metaR GLCAASE1ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
kinetic law: MODEL1310110039#
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110039#
reversible: false
type: Reaction
is: SBO:0000176

metaM r5p r
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
name: alpha-D-Ribose 5-phosphate
type: Species
initial concentration: 1.0
is: HMDB00618
has only substance units: false
is: CHEBI:18189
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_2e3c24ed_c085_40b0_b607_7da8aeca7c44
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:522
boundary condition: true
type: Species
constant: false
is: P18859
initial concentration: NaN
name: ATP5J
has only substance units: false

metaM 3ddcrn e
initial concentration: 1.0
is: C02838
type: Species
is: HMDB00791
boundary condition: false
initial amount: NaN
has only substance units: false
name: 3-hydroxydodecanoylcarnitine
is: SBO:0000247
constant: false
notes: FORMULA: C19H37NO5 CHARGE: 0

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110039#
modifier: MODEL1310110039#

metaR OCDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110039#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
is described by: ECO:0000000

metaM so4 l
has only substance units: false
constant: false
is: CHEBI:16189
type: Species
boundary condition: false
is: HMDB01448
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
initial concentration: 1.0
name: sulfate

metaM HC01444 e
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: CHEBI:15754
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: Galactosylglycerol

http://identifiers.org/biomodels.db/MODEL1310110039#_1159f1d9_9dc4_4ab7_8d57_6ccf6d355146
has only substance units: false
is encoded by: hsa:1806
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: DPYD
constant: false
is: Q12882

metaR FATP1t
reversible: true
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: fatty acid electroneutral transport
product: MODEL1310110039#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
name: ammonium
initial amount: NaN
boundary condition: false
is: CHEBI:28938
is: HMDB00051
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_73ca2023_966b_465d_91ea_a3a73d5ac91f
constant: false
has only substance units: false
name: _W87865_1_c
is encoded by: hsa:W87865
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaR ITPtn
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
kinetic law: MODEL1310110039#
name: ITP nuclear transport

metaR r0944
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
name: Active transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reversible: true
fast: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r1623
type: Reaction
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110039#_c5214cda_b84b_4502_8cd6_effc96655f9a
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: MTMR3
initial amount: NaN
boundary condition: true
is encoded by: hsa:8897
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_7a82009d_1a54_4ca0_a154_b6c2168809a9
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: ATP5G2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:517

metaR S2TASE2ly
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110039#
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176

metaR r0660
reactant: MODEL1310110039#
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f9c1e0bb_af94_42be_8270_149c16584ce0
boundary condition: true
type: Species
name: NDUFB8
initial concentration: NaN
is: O95169
is encoded by: hsa:4714
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_28bbb9a7_d3e7_4aff_b4f3_d8926e22628a
name: NDUFV3
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4731
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P56181

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR r0399
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
kinetic law: MODEL1310110039#

metaM mhista c
is: HMDB00898
initial amount: NaN
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
constant: false
is: CHEBI:58600
is: SBO:0000247
boundary condition: false
name: N(tele)-methylhistaminium
initial concentration: 1.0
type: Species
has only substance units: false

metaM m8mpdol U r
has only substance units: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
is: CHEBI:59093
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_82a20a63_26ef_4cbb_b4a1_6727d0939395
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:112
has only substance units: false
is: SBO:0000252
name: ADCY6
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d9c8515e_88f5_420b_aa20_bed95915ce8a
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:57835
is: SBO:0000252
initial amount: NaN
name: SLC4A5
has only substance units: false
boundary condition: true

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_65461f81_59f5_4e1c_a5cc_5928a65d2814
constant: false
has only substance units: false
is: Q06055
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ATP5G2
initial amount: NaN
is encoded by: hsa:517
type: Species

metaM val L c
name: L-valine
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00883
type: Species
constant: false
initial amount: NaN
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0

metaR r1622
type: Reaction
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0661
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
product: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#

metaR r0942
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
fast: false
kinetic law: MODEL1310110039#
reversible: true
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM 4mzym int2 r
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
name: 4-Methylzymosterol intermediate 2
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB06838

http://identifiers.org/biomodels.db/MODEL1310110039#_0a6654f8_b327_492e_b1bd_27a48b63447c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: A8K460
is encoded by: hsa:8398
constant: false
name: PLA2G6
initial concentration: NaN
is: SBO:0000252

metaR CYOR u10m
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000134
name: ubiquinol-6 cytochrome c reductase, Complex III
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/3.5.1.92
type: Reaction
reversible: false

metaM acetol c
is: CHEBI:27957
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial concentration: 1.0
is: HMDB06961
name: hydroxyacetone
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR FAOXC165C164m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
name: N-acetylgalactosamine-6-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_5cf41056_bb1f_44e9_b2dc_f2f6dabfe5d0
is: O75489
has only substance units: false
name: NDUFS3
is encoded by: hsa:4722
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_cf98208a_70be_4527_b824_0d108c6d8a28
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:84129
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q709F0
name: ACAD11
type: Species

metaM dgdp m
constant: false
is: HMDB00960
boundary condition: false
name: dGDP(2-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_bd832c57_f150_4d57_ac50_505a1239463f
has only substance units: false
type: Species
name: A4GNT
is: Q9UNA3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51146
constant: false
is: SBO:0000252
boundary condition: true

metaR CHAT
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110039#
reversible: true
name: Choline O-acetyltransferase

metaR MG2er
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#

metaM fadh2 m
type: Species
name: Flavin adenine dinucleotide reduced
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58307
constant: false
is: C01352

http://identifiers.org/biomodels.db/MODEL1310110039#_50399adb_12cd_4d74_8fe1_b4cfdcbfc04a
name: SLC25A19
initial amount: NaN
boundary condition: true
is encoded by: hsa:60386
is: Q9HC21
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR CYTK4
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
name: cytidylate kinase (dCMP)(GTP)
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is described by: ECO:0000269
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
fast: false

metaR UAG4E
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
reversible: true
fast: false
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/5.1.3.2
name: UDP-N-acetylglucosamine 4-epimerase
is: SBO:0000176

metaR S6TASE22ly
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#

metaR r1620
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000185
modifier: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
reversible: true

metaM 3hmp m
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoate
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
is: SBO:0000247
has only substance units: false
is: HMDB00023
constant: false
boundary condition: false
initial amount: NaN

metaM dgdp n
is: CHEBI:58595
is: HMDB00960
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
name: dGDP(2-)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a1b7cd24_4f2b_422f_b0a7_cb0bda3443e6
is: Q5SPY7
name: ENTPD2
type: Species
has only substance units: false
is encoded by: hsa:954
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b2ecdcf3_55d2_45d8_8818_d316fa76265a
initial amount: NaN
has only substance units: false
is: P22352
constant: false
type: Species
is encoded by: hsa:2878
name: GPX3
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR CYTK5
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
name: cytidylate kinase (dCMP)
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110039#

metaR HS3ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
product: MODEL1310110039#

metaR DMNONCRNt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
is: SBO:0000185
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaR r1621
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110039#

metaM udpg e
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
is: HMDB00286
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: CHEBI:58367
boundary condition: false

metaR It
reversible: true
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110039#
is described by: ECO:0000269
name: Iodide uniport
fast: false

metaR GALASE12ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110039#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000000
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110039#

metaR ETOHt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
name: ethanol reversible transport
kinetic law: MODEL1310110039#
fast: false
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM 6a2ohxnt x
initial amount: NaN
initial concentration: 1.0
is: HMDB12151
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: CHEBI:17534
type: Species
name: 6-amino-2-oxohexanoic acid

metaR FAOXC160
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
modifier: MODEL1310110039#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid

metaR CYTK2
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
name: cytidylate kinase (dCMP)
type: Reaction

metaR RE2659R
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: RE2659
product: MODEL1310110039#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false
reactant: MODEL1310110039#
type: Reaction

metaM hs deg25 l
type: Species
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H37O21 CHARGE: -1
is: CHEBI:15748
boundary condition: false
initial amount: NaN
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110039#_279dd02f_4b83_4ae5_b2f7_c20418bbd002
initial concentration: NaN
is: P12074
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1337
name: COX6A1

metaR CYTK3
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
fast: false
name: cytidylate kinase (CMP)(GTP)

http://identifiers.org/biomodels.db/MODEL1310110039#_617e36aa_9dd1_4d3d_aeeb_a6693a84c9a3
name: NDUFB9
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:4715
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q9Y6M9

http://identifiers.org/biomodels.db/MODEL1310110039#_0cceda49_474b_42dc_b484_9678f8f9d7af
has only substance units: false
constant: false
type: Species
name: UROD
initial amount: NaN
is encoded by: hsa:7389
is: SBO:0000252
initial concentration: NaN
is: P06132
boundary condition: true

metaM 3docopencoa m
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 3,7,10,13,16-docosapentenoylcoa
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaM udpg c
type: Species
is: C00029
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00286
name: UDPglucose
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
is: CHEBI:58367
initial amount: NaN

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
name: inorganic diphosphatase
reversible: false
is described by: ECO:0000269
fast: false

metaM tststerone c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: HMDB00234
constant: false
name: testosterone
is: CHEBI:17347
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR CYTK9
fast: false
name: cytidylate kinase (CMP,dCTP)
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR SUCCtp
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
name: succinate transporter, peroxisome
product: MODEL1310110039#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110039#
fast: false

metaM 2decdicoa x
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: 2,7-decadienoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaR SUCD1m
name: succinate dehydrogenase
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
modifier: MODEL1310110039#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1

metaM 9 cis retfa c
initial concentration: 1.0
is: SBO:0000247
name: fatty acid 9-cis-retinol
is: HMDB06217
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:17336
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_90edf8b2_465c_4ff8_a208_224ca090791a
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:9107
initial concentration: NaN
constant: false
initial amount: NaN
name: MTMR6
is: Q9Y217
has only substance units: false

metaR ADPCOACROT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR r0502
is version of: http://identifiers.org/ec-code/2.7.1.113
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaR RDH3
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: retinol dehydrogenase (11-cis,NADH)
type: Reaction
is: SBO:0000176
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
fast: false

metaR GMPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
kinetic law: MODEL1310110039#
name: GMP transport (Golgi)
product: MODEL1310110039#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110039#
reversible: true
fast: false

metaM ksii core2 deg4 l
constant: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1
boundary condition: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 4
is: CHEBI:57455
is: HMDB01354
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r0249
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.7.12
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is: SBO:0000176
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_87966ec9_c778_42df_a13d_e7de703feaea
constant: false
initial amount: NaN
is encoded by: hsa:AI990637
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI990637_1_x

metaR PETHCT
fast: false
name: phosphoethanolamine cytidyltransferase
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.14
modifier: MODEL1310110039#

metaM fadh2 r
constant: false
type: Species
is: CHEBI:58307
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01197
is: SBO:0000247
name: FADH2(2-)

metaR S4TASE4ly
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
type: Reaction

metaM so4 e
name: sulfate
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16189
initial amount: NaN

metaM doco13ecoa c
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
name: 13-docosenoylcoa
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_34bec922_d333_4390_bcaa_1768d5326677
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:9551
is: SBO:0000252
is: F8W7V3
type: Species
boundary condition: true
initial concentration: NaN
name: ATP5J2

metaR r0666
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
reversible: true
fast: false
modifier: MODEL1310110039#

metaM lanost r
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: HMDB01251
boundary condition: false
initial concentration: 1.0
is: CHEBI:16521
name: lanosterol
has only substance units: false
initial amount: NaN

metaR RDH2
reactant: MODEL1310110039#
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110039#
name: retinol dehydrogenase (9-cis,NADH)
is version of: http://identifiers.org/ec-code/1.1.1.315
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110039#_40c36eb1_7862_416e_a33a_44e07f8f51e2
has only substance units: false
constant: false
is encoded by: hsa:4023
initial amount: NaN
initial concentration: NaN
is: P06858
is: SBO:0000252
boundary condition: true
type: Species
name: LPL

http://identifiers.org/biomodels.db/MODEL1310110039#_98a02e78_53ad_495a_8022_61c9b558aa8b
type: Species
initial concentration: NaN
name: ATP2B1
constant: false
boundary condition: true
is encoded by: hsa:490
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P20020

http://identifiers.org/biomodels.db/MODEL1310110039#_873ebba6_cff2_4701_9e0f_f6e1ce04001f
is encoded by: hsa:T83654
initial concentration: NaN
type: Species
name: _T83654_1_m
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_22284f43_b068_4a75_8791_7d8c4336695a
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: Q308M7
is: SBO:0000252
name: ENPP3
is encoded by: hsa:5169
initial concentration: NaN
boundary condition: true

metaM dectricoa m
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
name: 2,4,7-decatrienoylcoa
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

metaR MAL Ltx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is: SBO:0000185
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
name: Transport reaction for malate
is described by: ECO:0000134

metaR ALAR
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: alanine racemase
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is described by: ECO:0000212
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110039#

metaM 3deccrn e
notes: FORMULA: C17H33NO5 CHARGE: 0
is: HMDB02250
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: 3-hydroxydecanoylcarnitine

metaR FACOAL1822
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR r0504
kinetic law: MODEL1310110039#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
type: Reaction
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reversible: true
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000000

metaR RE1691M
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.8.1.1
name: RE1691
product: MODEL1310110039#
reactant: MODEL1310110039#

metaM tststerone e
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
initial amount: NaN
name: testosterone
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00234

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
is: C04352
is: HMDB01117
initial concentration: 1.0
type: Species
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
boundary condition: false
is: CHEBI:59458
constant: false
is: SBO:0000247

metaR FAOXC101C102m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_60609407_f519_4f6d_9cec_e04eaec118b2
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _22305_1_c
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:22305

metaR r0669
reversible: false
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_d23f5578_dc40_47c3_a530_360d2de0ad50
constant: false
has only substance units: false
is encoded by: hsa:6548
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: SLC9A1
is: P19634

metaR FAOXC163x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_906b26a4_08c9_4600_8210_732ab57c9e07
initial concentration: NaN
is encoded by: hsa:6520
has only substance units: false
is: P08195
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC3A2
type: Species
boundary condition: true

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM cs a deg5 l
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H36O24S CHARGE: -2
is: CHEBI:15936
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_273d1753_b325_41a7_b66f_4ba92136be0a
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:50
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q99798
name: ACO2

metaR CYTK6
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaR RDH1
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
fast: false
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110039#
modifier: MODEL1310110039#
name: retinol dehydrogenase (all-trans)
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110039#

metaR CYTK8
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
name: cytidylate kinase (CMP,dATP)
modifier: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110039#
fast: false
type: Reaction

metaR G14T8g
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110039#
type: Reaction

metaR MG1er
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.106
fast: false
reactant: MODEL1310110039#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110039#
product: MODEL1310110039#

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01448
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: sulfate
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110039#_cfeb0996_94d7_4cb2_a318_6e861504cafd
boundary condition: true
type: Species
constant: false
is encoded by: hsa:137872
name: ADHFE1
initial amount: NaN
has only substance units: false
is: Q8IWW8
initial concentration: NaN
is: SBO:0000252

metaR r0668
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
kinetic law: MODEL1310110039#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110039#

metaR CYTK7
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,UTP)
reversible: true

metaR r0246
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: false
fast: false

metaM 4aphdob c
is: HMDB00978
is: CHEBI:58147
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: SBO:0000247
constant: false

metaR GLYCTDle
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000134
name: difussion of glycerol accross the brush border membrane
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110039#

metaR r0245
modifier: MODEL1310110039#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_dc25ef3c_f22b_40ce_8c7a_f10550668c56
boundary condition: true
type: Species
name: ACSS1
is: Q9NUB1
is encoded by: hsa:84532
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM val L m
is: SBO:0000247
is: CHEBI:16414
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
is: HMDB00883
name: L-valine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaM ocdca c
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629
initial amount: NaN
name: stearate

metaR FAOXC101C102x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaM vitd3 e
is: HMDB00876
is: CHEBI:28940
name: calciol
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e35425d2_55bc_432e_8d96_e8e7a367e56c
constant: false
is encoded by: hsa:5294
boundary condition: true
has only substance units: false
has part: P48736
is: SBO:0000297
initial amount: NaN
name: HCST:PIK3CG
initial concentration: NaN
is encoded by: hsa:10870
has part: Q9UBK5
type: Species

metaM 34hpp c
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
initial concentration: 1.0
is: CHEBI:36242
initial amount: NaN
boundary condition: false
name: 3-(4-hydroxyphenyl)pyruvate

metaR r2088
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_b509d536_c9f4_4750_b209_610ae0d2a71b
has only substance units: false
type: Species
is encoded by: hsa:4706
boundary condition: true
name: NDUFAB1
is: SBO:0000252
constant: false
initial amount: NaN
is: O14561
initial concentration: NaN

metaM utp n
initial amount: NaN
name: UTP(4-)
type: Species
constant: false
is: HMDB00285
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
boundary condition: false

metaR CREATt4 2 r
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is: SBO:0000185
name: Creatine transport (sodium symport) (2:1)
product: MODEL1310110039#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110039#_e9b02dde_0211_4c25_8e0a_70058b6e4c9e
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFA1
boundary condition: true
is: Q6IBB5
initial amount: NaN
is encoded by: hsa:4694
constant: false
is: SBO:0000252

metaM pro D c
is: HMDB03411
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0
constant: false
name: D-proline
boundary condition: false
is: SBO:0000247
is: CHEBI:16313
initial amount: NaN
type: Species

metaM xol7ah2al m
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: HMDB06894
boundary condition: false
is: CHEBI:27428

metaR r2089
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR FACOAL1821
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176

metaR CSPG Btly
reversible: false
name: chondroitin sulfate B transport, extracellular to lysosome
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110039#

metaR AACOAT
fast: false
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is version of: http://identifiers.org/ec-code/6.2.1.16
reversible: true
kinetic law: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
name: Acetoacetyl-CoA:acetate CoA-transferase
is: SBO:0000176
product: MODEL1310110039#

metaM ocdca e
has only substance units: false
is: C01530
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)
is: SBO:0000247
constant: false
is: CHEBI:25629
initial amount: NaN
type: Species
is: HMDB00827
boundary condition: false

metaR HDECEACBP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.61
reactant: MODEL1310110039#
product: MODEL1310110039#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reversible: false
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000304
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB

metaM tststerone r
initial amount: NaN
name: testosterone
boundary condition: false
is: CHEBI:17347
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
type: Species
is: HMDB00234
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_2655226d_f07c_4f02_8292_dbb3d8cc6f23
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:51557
name: LGSN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q5TDP6

metaM 34hpp e
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
is: SBO:0000247
is: HMDB00707
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1

http://identifiers.org/biomodels.db/MODEL1310110039#_b530b559_d006_4586_b2f2_8b11d31feb48
is: Q86U05
is encoded by: hsa:23428
constant: false
boundary condition: true
has only substance units: false
name: SLC7A8
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_b8f8fbc3_a666_4096_9edd_7a6944b86ffe
constant: false
type: Species
is: E7EX19
initial concentration: NaN
has only substance units: false
name: PIK3R1
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5295

metaM vitd3 c
name: calciol
is: HMDB00876
is: CHEBI:28940
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false

metaR BUTt2r
type: Reaction
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
is: SBO:0000185
modifier: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
name: Butyrate transport via proton symport, reversible
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110039#_7f8e51b2_070c_4ad1_b0e6_1bdc299f203b
is: SBO:0000252
constant: false
boundary condition: true
is: P04746
is encoded by: hsa:279
initial concentration: NaN
name: AMY2A
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_eaba3343_860c_4628_9a55_95e1ef97fa71
constant: false
initial concentration: NaN
type: Species
name: NDUFS3
is encoded by: hsa:4722
is: O75489
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR EX ddecrn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_3868cc57_6b39_4ca4_a5cf_78c2496c70b7
has only substance units: false
initial amount: NaN
is: O95045
is encoded by: hsa:151531
constant: false
name: UPP2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_3e725aee_122b_4bad_a0d9_c602c670dc2c
initial concentration: NaN
initial amount: NaN
is: P56181
is encoded by: hsa:4731
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: NDUFV3

metaM glyald m
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01051
name: D-glyceraldehyde
is: CHEBI:17378
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247

metaR r0242
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is version of: http://identifiers.org/ec-code/6.2.1.1
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_9220a799_aa02_4ae8_8bc5_0f7394bf58b7
is encoded by: hsa:83697
has only substance units: false
name: SLC4A9
type: Species
initial concentration: NaN
initial amount: NaN
is: E9PDK1
constant: false
boundary condition: true
is: SBO:0000252

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_bba0d6e8_780e_48f7_a6b0_11623307adfb
name: CHST1
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:8534
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: O43916

http://identifiers.org/biomodels.db/MODEL1310110039#_17f3ddb1_f44a_4a3c_b66a_b8fdae157d66
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: _AI697028_1_m
is encoded by: hsa:AI697028
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM fe3 c
notes: FORMULA: Fe CHARGE: 3
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Fe3+
has only substance units: false
type: Species
is: HMDB12943
boundary condition: false
initial amount: NaN

metaM ksi pre8 g
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 8
constant: false

metaM cs e deg5 l
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57737
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: HMDB00868

http://identifiers.org/biomodels.db/MODEL1310110039#_2e146f55_2268_4e16_80e3_1e1c873a08b7
is: SBO:0000252
initial concentration: NaN
name: ATP5H
boundary condition: true
is: O75947
has only substance units: false
type: Species
is encoded by: hsa:10476
initial amount: NaN
constant: false

metaM xylu L c
is: HMDB00751
boundary condition: false
type: Species
name: L-xylulose
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:17399
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
constant: false
initial concentration: 1.0

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16126

metaR FACOAL180i
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
name: C180 fatty acid activation
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110039#

metaM c4crn x
has only substance units: false
initial concentration: 1.0
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
initial amount: NaN
type: Species
is: HMDB02013
boundary condition: false
is: SBO:0000247
constant: false
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144

metaR r2084
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110039#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#

metaM ddcacoa m
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
name: Dodecanoyl-CoA (n-C12:0CoA)
has only substance units: false
constant: false
is: C01832
is: SBO:0000247
is: HMDB03571
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57375

metaM ksii core4 deg4 l
is: HMDB01354
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57455
name: keratan sulfate II (core 4-linked), degradation product 4
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C66H108N6O48SX CHARGE: -1

metaR G14T20g
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110039#_8c9e2fc0_1245_41a2_9878_800fda9fe042
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4831
name: NME2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P22392

metaM pydam c
name: Pyridoxamine
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00534
is: HMDB01431
type: Species
boundary condition: false
is: CHEBI:57761

metaM ksi pre29 g
is: CHEBI:28067
constant: false
boundary condition: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN

metaR r0033
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
type: Reaction
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_f1ad38ce_4c5d_497e_8c0f_6a2186fe9da3
is encoded by: hsa:27068
initial concentration: NaN
boundary condition: true
name: PPA2
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaM tym c
is: HMDB00306
is: SBO:0000247
initial amount: NaN
is: CHEBI:327995
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: tyraminium
constant: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483

http://identifiers.org/biomodels.db/MODEL1310110039#_c8edd3b6_f9e0_4609_8887_698fb329a44f
is encoded by: hsa:27068
boundary condition: true
is: F8WDN9
is: SBO:0000252
name: PPA2
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR CITtam
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reactant: MODEL1310110039#
modifier: MODEL1310110039#

metaR FAOXC6C4x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaM tettet6coa c
is: HMDB06516
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
has only substance units: false
is: C16171
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481

metaR DDPGAm
product: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_cd286e0d_ebc1_45b7_aa9e_018d28a9a893
is: P09972
boundary condition: true
initial concentration: NaN
name: ALDOC
is encoded by: hsa:230
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaR r0509
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000000
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_486f4719_a901_464b_96dd_6b4ae2483af8
name: SLC24A3
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:57419
boundary condition: true
initial amount: NaN
is: Q9HC58
initial concentration: NaN
type: Species

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
fast: false
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaR r2085
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
type: Reaction
reactant: MODEL1310110039#

metaM ksi pre11 g
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
type: Species
name: keratan sulfate I biosynthesis, precursor 11
boundary condition: false
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_bfbdb838_0580_40f5_99dc_b72eff9aee3a
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4129
type: Species
is: SBO:0000252
boundary condition: true
name: MAOB
is: P27338

metaR FAOXC200180m
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: false

metaR NACHEXA22ly
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false

metaR ADNt5le
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
name: adenosine transport (1:2 Na/Adn cotransport)
fast: false
reactant: MODEL1310110039#
reversible: false

metaM fe3 e
initial concentration: 1.0
name: Fe3+
type: Species
is: HMDB12943
has only substance units: false
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial amount: NaN
boundary condition: false
is: CHEBI:29034
constant: false
is: SBO:0000247

metaM nadph c
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
initial concentration: 1.0
type: Species
is: HMDB00221
boundary condition: false
is: C00005
constant: false

MODEL1310110039
reaction: metaR r0068
reaction: metaR RE3269C
reaction: metaR ASPDxt
reaction: metaR RTOTALt
reaction: metaR FAS160COA
reaction: metaR ACHtn
reaction: metaR r2332
species: metaM 3pg m
reaction: metaR ADCim
species: metaM acgam6p c
reaction: metaR GLCMter
reaction: metaR FACOAL170
species: metaM uppg3 c
reaction: metaR r0552
species: metaM met L c
reaction: metaR C80CPT1
reaction: metaR ACACT10m
species: metaM lpchol hs e
reaction: metaR RE1526M
time units: time
reaction: metaR NDPK1
species: metaM sebcoa c
reaction: metaR EX dhap LPAREN e RPAREN
reaction: metaR sink tetdec2coa LPAREN c RPAREN
reaction: metaR r0797
reaction: metaR r0149
reaction: metaR r2387
reaction: metaR SUCCtp
species: metaM 3octdece1crn e
species: metaM ksi deg10 l
species: metaM xol7ah2al m
species: metaM HC00342 c
species: metaM ppi n
reaction: metaR FACOAL1822
reaction: metaR VALt5m
species: metaM tettet6 e
species: metaM dcyt e
reaction: metaR EX ctp LPAREN e RPAREN
reaction: metaR PItn
reaction: metaR r0722
reaction: metaR EX dha LPAREN e RPAREN
volume units: volume
reaction: metaR XOLDIOLONEt
reaction: metaR GTHOm
species: metaM sphgn c
reaction: metaR r0514
reaction: metaR EX tag hs LPAREN e RPAREN
reaction: metaR DOLPMT2 Uer
reaction: metaR HPDCACRNCPT1
species: metaM dcmp c
reaction: metaR C180CPT2
species: metaM tag hs c
species: metaM ksii core2 l
reaction: metaR FE2t
species: metaM pyr m
reaction: metaR METyLATthc
species: metaM ksi pre27 g
reaction: metaR MANt1r
reaction: metaR ARACHCPT2
reaction: metaR r0655
species: metaM HC01401 x
reaction: metaR ACHEe
reaction: metaR EX strch2 LPAREN e RPAREN
species: metaM sphmyln hs c
species: metaM hs deg6 l
reaction: metaR BILDGLCURtr
species: metaM c3dc c
species: metaM 3hdeccoa m
species: metaM dadp c
reaction: metaR r1575
reaction: metaR FACOAL245 1
species: metaM dgmp e
species: metaM f6p c
species: metaM core4 g
species: metaM HC00900 c
reaction: metaR OAGT3te
reaction: metaR ELAIDCRNt
reaction: metaR GLYt2r
reaction: metaR GLCAASE5ly
species: metaM 3hibutcoa m

metaM grdp x
type: Species
initial concentration: 1.0
is: CHEBI:58057
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01285
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
has only substance units: false
name: geranyl diphosphate(3-)

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR r2086
modifier: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
reactant: MODEL1310110039#

metaR PPM
modifier: MODEL1310110039#
name: phosphopentomutase
kinetic law: MODEL1310110039#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.2
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#

metaM dectricoa x
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
constant: false
boundary condition: false
name: 2,4,7-decatrienoylcoa
initial concentration: 1.0
notes: FORMULA: C31H44N7O17P3S CHARGE: -4

metaM dgdp c
is: CHEBI:58595
name: dGDP
is: C00361
is: SBO:0000247
constant: false
is: HMDB00960
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361

metaR ATP2ter
is: SBO:0000185
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#

metaM sphs1p r
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
initial amount: NaN
is: CHEBI:60119
is: HMDB00277
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

metaR r2087
modifier: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_c8d7d0fb_57a2_4115_a1f4_332df30fa1f2
boundary condition: true
name: _AA526438_1_c
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AA526438
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_0b2cd4f4_4502_4f00_ab74_9b92330ed155
is: Q53HE2
is encoded by: hsa:7167
name: TPI1
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r2095
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false

metaM coa n
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB01423
is: CHEBI:57287
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM chsterol c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
constant: false
type: Species
is: CHEBI:16113
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e1b16407_992f_48d3_b6d9_4af58ea09419
initial concentration: NaN
constant: false
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252
has only substance units: false
name: _HG2846_HT2983_1_m
initial amount: NaN
type: Species
boundary condition: true

metaR 2HBO
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: true
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

metaM gdp g
is: CHEBI:58189
type: Species
name: GDP(3-)
boundary condition: false
is: HMDB01201
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

http://identifiers.org/biomodels.db/MODEL1310110039#_ab016a2e_7a82_4bc8_a865_a911a518c63c
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: ACAA2
initial amount: NaN
is: P42765
is encoded by: hsa:10449
constant: false

metaR ACACt2m
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: true
name: Acetoacetate mitochondrial transport via H+ symport
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
fast: false
product: MODEL1310110039#

metaR r1720
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110039#
reversible: false

metaR r0055
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.7
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110039#
fast: false

metaM acgam6p c
type: Species
is: HMDB01062
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: CHEBI:57513
boundary condition: false
constant: false
initial amount: NaN
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_962ef1e6_4cee_47e5_9db7_a6c6a6c2cbb7
boundary condition: true
is: Q9BYZ2
name: LDHAL6B
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:92483
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_34bed12c_e082_430c_97dd_f6b3d18478d7
boundary condition: true
is encoded by: hsa:LOC727762
has only substance units: false
type: Species
name: _LOC727762_1_m
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_a2ec234a_a4f4_4640_8802_215ffe0ade34
is: SBO:0000252
is encoded by: hsa:276
boundary condition: true
is: P04745
has only substance units: false
name: AMY1A
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_2f2ed796_ef9b_48e9_841e_e5a8f4fdfaad
is encoded by: hsa:11001
name: SLC27A2
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: O14975
boundary condition: true
is: SBO:0000252

metaR CYSGLUexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
name: L-cysteine/L-glutamine reversible exchanger
modifier: MODEL1310110039#
fast: false
is described by: ECO:0000304
is: SBO:0000185

metaM drib e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
initial concentration: 1.0
is: CHEBI:28816
is: HMDB03224
initial amount: NaN
has only substance units: false
name: 2-deoxy-D-ribose
type: Species

metaR C4x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaM stcrn m
constant: false
initial amount: NaN
name: stearoylcarnitine
is: HMDB00848
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR r2094
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110039#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#

metaM bilirub e
name: bilirubin(2-)
is: SBO:0000247
constant: false
is: CHEBI:57977
initial concentration: 1.0
type: Species
is: HMDB00054
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

http://identifiers.org/biomodels.db/MODEL1310110039#_f031fabd_d63c_4802_89c5_1e6ed15d0d65
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _D29675_1_c
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:D29675
type: Species

metaM 1p3h5c m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:6151
constant: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: HMDB01369

metaM ksi deg32 l
is: HMDB00143
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 32
type: Species
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
is: CHEBI:12936
initial concentration: 1.0
is: SBO:0000247

metaM dopa e
constant: false
is: HMDB00073
name: dopaminium(1+)
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:59905
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR BAMPPALDOX
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110039#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
reactant: MODEL1310110039#
modifier: MODEL1310110039#

metaM cl e
type: Species
is: HMDB00492
name: Chloride
constant: false
is: C00115
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
boundary condition: false
has only substance units: false
is: CHEBI:3966
initial concentration: 1.0
initial amount: NaN

metaM ddcacoa c
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: C01832
is: HMDB03571
is: CHEBI:57375
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial amount: NaN

metaR P45027A1m
fast: false
kinetic law: MODEL1310110039#
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110039#
name: Cytochrome P450 27
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_eaa200a7_c3e4_4fd4_8940_f0c8e3c6d305
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:64902
type: Species
is: SBO:0000252
is: Q9BYV1
initial amount: NaN
initial concentration: NaN
name: AGXT2

metaM 3hdececrn c
type: Species
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: 3-hydroxyhexadecenoylcarnitine
is: HMDB02014
initial amount: NaN

metaR ATPtx
fast: false
is: SBO:0000185
name: ATP transporter, peroxisomal
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

metaR r2093
fast: false
reactant: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110039#
reversible: true
is: SBO:0000185

metaR ENGASEly
product: MODEL1310110039#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110039#

metaM tethex3 e
type: Species
is: HMDB02007
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: tetracosahexaenoic acid, n-3
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial concentration: 1.0
is: SBO:0000247

metaM nadph x
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
boundary condition: false
is: CHEBI:57783
constant: false
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005

http://identifiers.org/biomodels.db/MODEL1310110039#_b9900a92_d7c9_40da_928b_2742e5b10633
constant: false
is: SBO:0000252
name: NDUFS7
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:374291
initial concentration: NaN
initial amount: NaN
is: O75251

http://identifiers.org/biomodels.db/MODEL1310110039#_0a2bf2d1_7027_47a7_904b_3acd62126ab6
boundary condition: true
type: Species
constant: false
name: NDUFB2
initial concentration: NaN
is encoded by: hsa:4708
is: SBO:0000252
initial amount: NaN
is: H7C5B8
has only substance units: false

metaR S6TASE14ly
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
product: MODEL1310110039#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110039#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: Core 6
type: Species
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
is: SBO:0000247

metaM T antigen g
constant: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
has only substance units: false
is: CHEBI:22783
boundary condition: false
type: Species
name: T antigen (core 1)
initial concentration: 1.0
initial amount: NaN

metaR ACGPID
product: MODEL1310110039#
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
reversible: false
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.89
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
kinetic law: MODEL1310110039#
is described by: ECO:0000269

metaM coa l
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:57287
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
type: Species

metaM dece3coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 3-decenoylcoa
constant: false
type: Species

metaM kynate c
is: SBO:0000247
is: CHEBI:58454
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: kynurenate
is: HMDB00715
constant: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717

metaM chsterol e
name: cholesterol
has only substance units: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00067
constant: false
initial amount: NaN
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110039#_91664293_5763_40fc_bc5f_9b9dcc582521
is encoded by: hsa:3418
initial concentration: NaN
type: Species
name: IDH2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is: P48735
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_83c8aa27_a3a6_471d_a10c_afbf22392c87
type: Species
has only substance units: false
initial concentration: NaN
name: _AI469183_1_x
is encoded by: hsa:AI469183
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2092
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000000

metaR DM ethamp r
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_7ad39f25_0221_4d0f_beaf_81abbb6f44c0
has only substance units: false
type: Species
is: Q6LEN6
constant: false
boundary condition: true
name: CHAT
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1103
initial concentration: NaN

metaM drib c
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28816
has only substance units: false
is: HMDB03224
initial amount: NaN
name: 2-deoxy-D-ribose
boundary condition: false

metaM tethex3 c
is: HMDB02007
boundary condition: false
constant: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: tetracosahexaenoic acid, n-3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ca8ccaa1_1583_4622_9170_f0727c3828f0
initial concentration: NaN
name: PPA2
is: Q9H2U2
is encoded by: hsa:27068
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM pristcoa c
is: SBO:0000247
is: CHEBI:51341
initial amount: NaN
boundary condition: false
name: pristanoyl coa
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2

http://identifiers.org/biomodels.db/MODEL1310110039#_65c0eecb_01b2_4d93_92bf_454c1885c47e
is: P14060
constant: false
is encoded by: hsa:3283
name: HSD3B1
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM coa m
initial amount: NaN
is: SBO:0000247
name: Coenzyme A
initial concentration: 1.0
is: CHEBI:57287
boundary condition: false
type: Species
is: C00010
has only substance units: false
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110039#_3e98e8d4_d705_42dc_9915_0cea32d6e030
constant: false
initial amount: NaN
is: SBO:0000252
name: SGPL1
initial concentration: NaN
type: Species
has only substance units: false
is: O95470
boundary condition: true
is encoded by: hsa:8879

http://identifiers.org/biomodels.db/MODEL1310110039#_3d6321d7_e905_4d83_8464_aef87cbcbc7f
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110039#_9e04ba44_6b4e_43e5_b10f_8eac5821b385
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8875
name: VNN2
constant: false
is: A8K7W0

http://identifiers.org/biomodels.db/MODEL1310110039#_c8aa2cea_c49f_468c_833a_daa842a457c8
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:AL050025
name: _AL050025_1_c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaM dcyt c
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
initial concentration: 1.0
is: HMDB00014
is: SBO:0000247
initial amount: NaN
type: Species
name: Deoxycytidine
boundary condition: false
has only substance units: false
is: CHEBI:15698

metaR HDCAtr
product: MODEL1310110039#
reversible: true
is: SBO:0000185
type: Reaction
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR r1007
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110039#
name: Facilitated diffusion
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110039#

metaM ksi deg18 l
type: Species
name: keratan sulfate I, degradation product 18
constant: false
has only substance units: false
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
is: SBO:0000247

metaR r2091
fast: false
is: SBO:0000185
reactant: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM bilirub c
constant: false
initial concentration: 1.0
type: Species
is: HMDB00054
has only substance units: false
name: bilirubin(2-)
boundary condition: false
is: CHEBI:57977
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247

metaM arachcrn m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: arachidyl carnitine
is: HMDB06460
constant: false
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaM retfa c
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:50211
is: SBO:0000247
name: fatty acid retinol
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00305
type: Species
constant: false
initial concentration: 1.0

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r1619
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
is: SBO:0000185

metaR CMPSASn
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110039#
name: CMP sialic acid synthase, nuclear
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

metaR UMPK4
kinetic law: MODEL1310110039#
fast: false
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: true
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_cc243a81_24d6_4fe2_8631_c603a202ac3c
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM ametam c
is: HMDB00988
initial amount: NaN
initial concentration: 1.0
constant: false
is: C01137
is: SBO:0000247
name: S-Adenosylmethioninamine
is: CHEBI:57443
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
boundary condition: false
type: Species
has only substance units: false

metaR RE3626M
product: MODEL1310110039#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000176
name: RE3626
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction

metaM 4hglusa m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false
name: L-4-hydroxyglutamic semialdehyde
type: Species
is: HMDB06556
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:27809

metaR r2090
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r0051
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is: SBO:0000176
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_213018e4_9a98_4a59_adbc_22e3ac8ef85a
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: _AI924226_1_m
is encoded by: hsa:AI924226

metaR r0801
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_e535c484_8327_4283_9456_2709fc87e786
initial concentration: NaN
initial amount: NaN
has part: A3KLL5
has only substance units: false
constant: false
is encoded by: hsa:481
is: SBO:0000297
type: Species
boundary condition: true
name: ATP1A3:ATP1B1
has part: B7Z2T0
is encoded by: hsa:478

metaR HMGCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_337d2097_4863_44f8_9709_9b929fda2eed
type: Species
initial amount: NaN
name: _2544_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2544
initial concentration: NaN
has only substance units: false
constant: false

metaR r1618
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR UMPK3
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP)
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110039#

metaM octd11ecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 11-octadecenoylcoa
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB00792
is: C08277

metaM dhbpt c
is: HMDB00038
initial amount: NaN
name: 6,7-dihydrobiopterin
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:20680
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_f734276f_f271_4f82_bef1_c7e6a2f94f60
is encoded by: hsa:53
name: ACP2
has only substance units: false
is: E9PCI1
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaM orot c
is: C00295
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00226
constant: false
name: Orotate
has only substance units: false
is: CHEBI:30839
type: Species
initial concentration: 1.0
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

http://identifiers.org/biomodels.db/MODEL1310110039#_ef265a3b_0fd1_4153_bc6a_603d0a71ef4a
has only substance units: false
name: HYAL3
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: O43820
boundary condition: true
type: Species
is encoded by: hsa:8372

metaM m5mpdol U r
boundary condition: false
type: Species
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:37634
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110039#_84300c5e_1948_4468_bdd6_d9bd1941cd6e
is: Q86SK9
name: SCD5
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:79966
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM pail5p hs n
has only substance units: false
is: SBO:0000247
is: CHEBI:57795
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0

metaR SIAASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
reactant: MODEL1310110039#
name: sialidase, lysosomal

metaR DNDPt36m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
type: Reaction
name: dGDP transport via dCDP antiport
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_412dc686_f72f_46d6_b954_0ff73166411e
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: NT5C3
has only substance units: false
is encoded by: hsa:51251
is: Q9H0P0

http://identifiers.org/biomodels.db/MODEL1310110039#_061f4640_cf5e_4c1f_9d70_ed214f95f10b
is encoded by: hsa:29968
initial amount: NaN
boundary condition: true
name: PSAT1
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaM citr L e
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
name: citr_L[e]

metaR XYLTt
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
name: Xylitol transport via passive diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM fadh2 c
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01197
constant: false
is: SBO:0000247
is: CHEBI:58307
initial amount: NaN
name: FADH2(2-)
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species

metaM CE5868 e
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:27485
boundary condition: false
initial amount: NaN
name: N-acetyl-seryl-aspartate
initial concentration: 1.0
is: HMDB02710
notes: FORMULA: C9H12N2O7 CHARGE: -2 INCHI: InChI=1/C9H14N2O7/c1-4(13)10-6(3-12)8(16)11-5(9(17)18)2-7(14)15/h5-6,12H,2-3H2,1H3,(H,10,13)(H,11,16)(H,14,15)(H,17,18)/p-2/t5-,6+/m1/s1 EHMN_ABBREVIATION: CE5868
type: Species

metaM hs deg5 l
type: Species
is: SBO:0000247
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
name: heparan sulfate, degradation product 5
is: CHEBI:17895
initial amount: NaN
is: HMDB00158
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1726
type: Reaction
reversible: false
product: MODEL1310110039#
is: SBO:0000185
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Y+LAT2 Utilized transport

metaR UMPK2
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: UMP kinase (CTP)
reversible: true
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000269
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_9186a31f_16f6_4649_b2e1_6390309e3d54
is: F5H8B1
is: SBO:0000252
constant: false
name: PCYT2
is encoded by: hsa:5833
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_26c8f6bf_9343_4302_b1e4_30294a368de3
boundary condition: true
has only substance units: false
is: B4DK61
initial concentration: NaN
name: ACOX1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51
type: Species
constant: false

metaM retfa e
is: HMDB00508
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
name: fatty acid retinol
boundary condition: false
has only substance units: false
is: CHEBI:15963
type: Species
constant: false
initial concentration: 1.0

metaM udpg r
is: CHEBI:58367
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00286
initial amount: NaN
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d103533a_6d79_4afc_a7cb_fcdaf734c46e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55
initial concentration: NaN
has only substance units: false
is: P15309
initial amount: NaN
name: ACPP
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_958dfe3d_2da4_4714_8e82_dee5689a624e
has only substance units: false
boundary condition: true
is encoded by: hsa:4842
is: B4DG68
type: Species
is: SBO:0000252
initial amount: NaN
name: NOS1
initial concentration: NaN
constant: false

metaR GLNS
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction
reversible: false
modifier: MODEL1310110039#
product: MODEL1310110039#
name: glutamine synthetase
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000254

metaM ksii core2 deg5 l
constant: false
is: SBO:0000247
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 5
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: CHEBI:12936
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3c438bb0_6dc3_4117_8b7b_04ceca09c6e0
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: UCK1
is encoded by: hsa:83549
is: SBO:0000252
initial concentration: NaN
is: Q5JT09

metaM orn m
initial amount: NaN
name: Ornithine
is: SBO:0000247
is: HMDB00214
initial concentration: 1.0
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:46912
boundary condition: false
constant: false
has only substance units: false
is: C01602

metaR XYLUR
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is described by: ECO:0000269
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.10
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: xylulose reductase
reactant: MODEL1310110039#
fast: false

metaM 3mb2coa m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: CHEBI:57344
boundary condition: false
type: Species
has only substance units: false
constant: false
is: HMDB01493

metaR C6DCCACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM orot e
initial amount: NaN
name: orotate
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00226
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
is: CHEBI:30839
boundary condition: false
initial concentration: 1.0

metaR RETHe
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reversible: false
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
name: retinyl ester hydrolase, extracellular

metaR URIt
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
name: uridine facilated transport in cytosol
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#

metaR FAOXC102C103m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR ALAGLNexR
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000304
type: Reaction
reversible: true
name: L-alanine/glutamine reversible exchange
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM glyb c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00043
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17750
name: glycine betaine
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaM 3hdececrn e
notes: FORMULA: C23H43NO5 CHARGE: 0
constant: false
boundary condition: false
is: HMDB12930
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: 3-hydroxyhexadecenoylcarnitine

http://identifiers.org/biomodels.db/MODEL1310110039#_ceb45499_9d7f_43cb_8261_2bc001a6f729
initial concentration: NaN
name: LPGAT1
type: Species
boundary condition: true
is encoded by: hsa:9926
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q92604

http://identifiers.org/biomodels.db/MODEL1310110039#_65c2cbd6_258c_47d6_88dd_fa71faae5e30
is: SBO:0000252
name: SRD5A1
is: P18405
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6715
boundary condition: true

metaR EX c8crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR FAOXC163Gm
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM cl c
initial amount: NaN
name: Chloride
initial concentration: 1.0
boundary condition: false
is: C00115
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
is: CHEBI:3966
has only substance units: false
constant: false
type: Species
is: HMDB00492

metaM ksi deg26 l
name: keratan sulfate I, degradation product 26
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:58343
boundary condition: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: HMDB00061
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_ed65cc81_9a8c_4acd_b3d6_8958e8f51ce7
constant: false
name: SGPP1
initial amount: NaN
is: Q9BX95
type: Species
is encoded by: hsa:81537
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e867af37_9d02_4190_898f_d82c579b9987
is: SBO:0000252
name: SLC27A1
initial amount: NaN
is encoded by: hsa:376497
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN

metaR r0383
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.1 Confidence Level: 0 AUTHORS: PMID:18032470,PMID:2323578,PMID:2748588 NOTES:
product: MODEL1310110039#
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
name: pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1

http://identifiers.org/biomodels.db/MODEL1310110039#_d0afa193_f75a_4154_ac9f_09e617ab7d45
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PDE7A
boundary condition: true
type: Species
constant: false
is encoded by: hsa:5150
is: Q13946
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_96053aa2_774f_40e8_80cc_4f3252a10d96
is encoded by: hsa:8034
has only substance units: false
is: P16260
initial concentration: NaN
name: SLC25A16
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR r0652
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b51ba9aa_f12d_4b17_9760_8659f493f963
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: ADO
constant: false
initial amount: NaN
is encoded by: hsa:84890
boundary condition: true
is: B3KXN9

metaR AMETtd
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: diffusion of S-Adenosyl-L-methionine
type: Reaction
fast: false
product: MODEL1310110039#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_b7c75971_8d0a_4690_be3b_7ca541a7c15b
is: E5KSL6
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: DGUOK
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1716

metaR PI4PP
is: SBO:0000176
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
name: phosphatidylinositol-4-phosphate 4-phosphatase
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
type: Reaction

metaR C161CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110039#
reversible: false
fast: false
name: production of palmitoleoylcarnitine
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
type: Reaction
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110039#

metaR CRNCAR3tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:copied from NCD's CRNCARtp NJ
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
name: carnitine-propcarnitine carrier, peroxisomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_625f6ac9_4a05_47ae_a2fc_718333d76933
constant: false
initial concentration: NaN
has only substance units: false
name: INPP5J
boundary condition: true
is: SBO:0000252
is: Q15735
type: Species
initial amount: NaN
is encoded by: hsa:27124

metaR AHEXASE2ly
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
name: beta-N-acetylhexosaminidase, lysosomal

metaR r1615
is described by: ECO:0000000
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
reversible: true
is: SBO:0000185

metaR EX CE4722 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin (1-6) exchange
type: Reaction

metaR r0384
kinetic law: MODEL1310110039#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reversible: false
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:

metaR r1614
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110039#

metaM chlstol r
initial amount: NaN
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: HMDB06842
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16290
boundary condition: false
type: Species
has only substance units: false

metaR MM6bg
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaM coa g
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57287
name: coenzyme A(4-)
initial amount: NaN

metaR IDOAASE3ly
product: MODEL1310110039#
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_d153b659_2da5_4a2d_a4f2_2d3685405f78
is encoded by: hsa:11001
type: Species
name: SLC27A2
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O14975
initial concentration: NaN
boundary condition: true
constant: false

metaR r0653
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#

metaM core6 g
name: Core 6
is: CHEBI:16478
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaR FAS140COA
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C14:0CoA)
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR TETTET6COAtx
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110039#
name: fatty acid intracellular transport
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction

metaR FAOXC225C204x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaM dece3coa x
is: SBO:0000247
type: Species
initial amount: NaN
name: 3-decenoylcoa
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false

metaR C161CPT2
modifier: MODEL1310110039#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110039#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reactant: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#

metaM dolp L r
name: dolichyl phosphate(2-)
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57683
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_9b1bf8c7_3953_4805_9eb3_a65aed93cbcd
is: SBO:0000252
initial concentration: NaN
is: Q8IZH9
constant: false
type: Species
name: GCH1
is encoded by: hsa:2643
initial amount: NaN
boundary condition: true
has only substance units: false

metaM gdp n
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01201
name: GDP(3-)
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_4d29ed20_b33f_4cc2_a85f_73d2e27e4ed7
initial concentration: NaN
is: Q86SR1
name: GALNT10
type: Species
is encoded by: hsa:55568
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR GLNASNNaEx
kinetic law: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
fast: false
reactant: MODEL1310110039#
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110039#

metaM CE2431 m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
name: cis-deca-4-enoyl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57795
constant: false

metaR CLFORtex
name: chloride transport via formate countertransport
type: Reaction
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#

metaR r0650
product: MODEL1310110039#
type: Reaction
reversible: true
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110039#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176

metaM malcoa r
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB01175
has only substance units: false
name: malonyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
is: SBO:0000247

metaR r0385
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110039#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_b9d4b3c7_1673_450b_a553_034946548995
name: ACP2
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:53
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: E9PCI1

http://identifiers.org/biomodels.db/MODEL1310110039#_f5decfa8_d2a4_4d65_8f55_55738b3858d8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4668
is: P17050
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
name: NAGA

metaM chsterol m
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
is: HMDB00067
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16113
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR TCYNTt
name: Thiocyanate transport via diffusion (cytosol to extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000

metaM pail5p hs c
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

metaR r1617
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM gdp m
is: C00035
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
boundary condition: false
constant: false
is: HMDB01201
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58189

metaM nadph m
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
boundary condition: false
has only substance units: false
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110039#_f9084796_bc91_4be1_88ce_e2bbc1f2b9a4
is: Q6NZ59
constant: false
name: ATP5J
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:522
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM octd11ecoa m
initial amount: NaN
is: HMDB06294
boundary condition: false
initial concentration: 1.0
name: 11-octadecenoylcoa
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
type: Reaction
reversible: true
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

metaR MTHFDm
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR r0386
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
product: MODEL1310110039#

metaM citr L c
name: L-citrulline
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:16349
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM 3deccrn c
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00651
initial concentration: 1.0
boundary condition: false
name: 3-hydroxydecanoylcarnitine
notes: FORMULA: C17H33NO5 CHARGE: 0
is: SBO:0000247

metaM chsterol l
is: CHEBI:16113
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
boundary condition: false
has only substance units: false
name: cholesterol

metaR FAOXC121x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR FAOXC143C123x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR r1616
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLNTHRNaEx
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
product: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f5547535_5824_499d_a625_1802755b8c96
name: BPNT1
type: Species
is: O95861
is encoded by: hsa:10380
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaM HC00342 c
constant: false
is: CHEBI:16383
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
boundary condition: false
name: cis-aconitate(3-)

metaM tmndnccrn m
has only substance units: false
boundary condition: false
constant: false
is: HMDB12130
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
initial concentration: 1.0
initial amount: NaN
name: Timnodonyl carnitine
is: SBO:0000247
type: Species
is: CHEBI:16987

metaR SR5AR2r
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6715.1) or (6716.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ
is: SBO:0000176
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
fast: false
reversible: false
reactant: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.5

metaR r1611
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
product: MODEL1310110039#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_bedc0f9e_1643_41c9_b03f_1c4bf55559f8
initial concentration: NaN
is encoded by: hsa:AI480132
is: SBO:0000252
name: _AI480132_1_c
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_98ccea94_4e27_4f0a_8b34_cd99204844b1
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:270
has only substance units: false
boundary condition: true
is: P23109
name: AMPD1
initial amount: NaN
constant: false

metaR GALASE19ly
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR O2St
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
product: MODEL1310110039#
name: superoxide anion transport via diffusion (extracellular)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaM retinol e
type: Species
name: retinol
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:50211
is: SBO:0000247
is: HMDB00305

http://identifiers.org/biomodels.db/MODEL1310110039#_11a96f7d_d920_4147_8a91_3207384d133a
name: MAN2A2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4122
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9P1E4

metaR r0388
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reversible: true
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false

metaM 4nph c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 4-nitrophenolate
type: Species
is: CHEBI:57917
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
constant: false
initial amount: NaN
has only substance units: false

metaM dcyt e
is: SBO:0000247
is: HMDB00014
initial concentration: 1.0
constant: false
is: C00881
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
is: CHEBI:15698
initial amount: NaN
name: Deoxycytidine
has only substance units: false

metaR r1610
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
type: Reaction

metaM pre prot r
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB03125
notes: FORMULA: XY CHARGE: 0
initial amount: NaN
is: CHEBI:16240
name: glycophosphatidylinositol (GPI)-anchored protein precursor
type: Species

metaM coa c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial amount: NaN
type: Species
is: CHEBI:3312
constant: false
is: HMDB01423
name: Coenzyme A
is: SBO:0000247
is: C00010
has only substance units: false

metaR r0954
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
fast: false
kinetic law: MODEL1310110039#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
name: MCT 1 Transport reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_26f1309d_6b4f_47e2_9647_1d4551a9a31c
initial amount: NaN
has only substance units: false
is: Q56NI9
constant: false
type: Species
is: SBO:0000252
name: ESCO2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:157570

metaM utp e
is: CHEBI:46398
has only substance units: false
is: SBO:0000247
name: UTP(4-)
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00285
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075

metaR 3AIBTm
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
name: L-3-aminoisobutyrate transaminase, mitochondrial
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR HDCEAtr
name: fatty acid transport via diffusion
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000

metaM acald c
initial amount: NaN
is: SBO:0000247
name: acetaldehyde
initial concentration: 1.0
is: CHEBI:15343
boundary condition: false
is: HMDB00990
constant: false
type: Species
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaR r0389
reversible: true
is: SBO:0000176
type: Reaction
fast: false
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:

metaR r1613
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
fast: false
type: Reaction

metaM arach c
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
is: HMDB02212
is: SBO:0000247
type: Species
initial concentration: 1.0
name: arachidate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_94b118e9_3115_4dc1_a800_e39975e9eeea
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:131669
is: SBO:0000252
type: Species
is: Q68CJ7
has only substance units: false
boundary condition: true
name: UROC1

metaM ksi deg10 l
initial concentration: 1.0
is: CHEBI:57455
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 10
is: HMDB01354
is: SBO:0000247
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
constant: false

metaM 4nph e
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 4-nitrophenolate
is: CHEBI:57917
is: HMDB01232
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_51cc073a_9277_450a_9449_a4b9e892f90d
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8528
constant: false
is: Q99489
name: DDO
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_513554b4_5e84_497c_85df_880a7a74d08e
has only substance units: false
is encoded by: hsa:AI090874
constant: false
type: Species
name: _AI090874_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_68c56776_a3cd_4176_8ddd_a33311298d38
is: A6NFM2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PYCR1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5831
boundary condition: true

metaR r1612
kinetic law: MODEL1310110039#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM 3docopencoa x
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_89cf79d9_e904_4d4b_91bc_6fa40dba8ba0
initial amount: NaN
constant: false
is: P14618
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5315
name: PKM2

metaM utp c
has only substance units: false
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00285
is: C00075
name: UTP

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM acald e
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
boundary condition: false
type: Species
name: acetaldehyde
is: CHEBI:15343
is: SBO:0000247
is: HMDB00990
has only substance units: false
initial amount: NaN
constant: false

metaM nadph r
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
type: Species
is: C00005

metaR HSAT4ly
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110039#
type: Reaction
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110039#

metaM cgly c
initial concentration: 1.0
has only substance units: false
is: CHEBI:4047
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
is: SBO:0000247
is: HMDB00078
name: L-cysteinylglycine
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_ac4d4139_6fa9_4905_8210_8f99de5c0c5a
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:53947
name: A4GALT
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9NPC4
is: SBO:0000252

metaM HC02202 e
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:57398
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
boundary condition: false
constant: false
name: prostaglandin A1(1-)

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
type: Species
is: SBO:0000247
is: HMDB00067
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16113

metaR r0239
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 0 AUTHORS: PMID:4140137,PMID:4190298 NOTES:
name: N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9
reversible: true
product: MODEL1310110039#
modifier: MODEL1310110039#

metaR ADPCOAPTE
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaM strdnccrn m
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB06463
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
name: stearidonyl carnitine
is: SBO:0000247
initial amount: NaN

metaR BTNt4i
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
name: Biotin uptake (antiport)
reversible: false
is described by: ECO:0000269
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185

metaR HPYRDC
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
kinetic law: MODEL1310110039#
name: hydroxypyruvate decarboxylase
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
reversible: false
type: Reaction
product: MODEL1310110039#
is: SBO:0000176

metaR r0512
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110039#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_2843a0a9_29b9_4c09_9fe0_820a7d881c2f
is: Q8NCL4
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:11226
name: GALNT6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM ksii core2 deg9 l
is: CHEBI:12936
constant: false
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 9
notes: FORMULA: C30H50N3O20X CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM CE4790 m
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: CHEBI:57923
initial concentration: 1.0
constant: false
type: Species

metaR GALASE11ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
fast: false
product: MODEL1310110039#

metaR SRTNtu
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Serotonin uniport
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110039#_b362e8d7_e06f_41cd_8bb9_3e6bd2ce9e28
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:80864
name: EGFL8
is: Q99944
constant: false

metaR P45011A1m
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: Cytochrome P450 11A1, mitochondrial [Precursor]
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
is version of: http://identifiers.org/ec-code/1.14.15.6
fast: false
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#

metaR ELAIDt
reversible: true
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

metaR DLNLCGCRNt
kinetic law: MODEL1310110039#
reversible: false
name: transport into the mitochondria (carnitine)
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110039#

metaM 2mpdhl m
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
constant: false
boundary condition: false
has only substance units: false
name: S-(2-Methylpropanoyl)-dihydrolipoamide
is: CHEBI:17577
initial concentration: 1.0

metaR C204CRNt
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
type: Reaction
name: arachidonic acid transport into the mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport

http://identifiers.org/biomodels.db/MODEL1310110039#_f521d7be_947f_4a10_b574_b9c9ab16bdc8
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ATP5G3
has only substance units: false
is encoded by: hsa:518
constant: false
is: SBO:0000252
type: Species
is: P48201

metaR r0390
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_0e1a41a6_ed69_4918_8f0e_f5b9fb742174
boundary condition: true
name: NDUFV3
is encoded by: hsa:4731
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
reactant: MODEL1310110039#
name: nicotinamide-nucleotide adenylyltransferase
modifier: MODEL1310110039#
is described by: ECO:0000269
reversible: true

metaM ksi deg34 l
is: SBO:0000247
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
constant: false
is: CHEBI:57455
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 34

metaM acglcgalgluside hs g
constant: false
is: CHEBI:17103
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
has only substance units: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_d0c47dcd_774b_43a0_b780_8e2342a34317
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: P21912
type: Species
name: SDHB
initial concentration: NaN
is encoded by: hsa:6390
initial amount: NaN

metaM 3ohdcoa m
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
is: HMDB06402

metaM asp L m
has only substance units: false
is: CHEBI:29991
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00191

metaM nh4 x
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
name: Ammonium
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB00051
is: CHEBI:28938
is: C01342
initial amount: NaN
is: SBO:0000247

metaM tmndnccrn c
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: Timnodonyl carnitine
is: SBO:0000247
is: CHEBI:16987
initial concentration: 1.0
is: HMDB12130
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
has only substance units: false

metaM retinol c
name: retinol
boundary condition: false
is: CHEBI:50211
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB00305
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
initial concentration: 1.0

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
name: bilirubin(2-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB00054
is: CHEBI:57977
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_353ac7ed_3a76_44a0_9fa2_7d0ceb233394
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1635
is: P32321
constant: false
type: Species
has only substance units: false
name: DCTD

http://identifiers.org/biomodels.db/MODEL1310110039#_b08e416d_a107_4a92_8da2_af1df25bc543
boundary condition: true
is encoded by: hsa:291
initial concentration: NaN
type: Species
name: SLC25A4
is: SBO:0000252
has only substance units: false
is: P12235
constant: false
initial amount: NaN

metaM tetdec2crn e
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB05066
initial concentration: 1.0
constant: false
notes: FORMULA: C21H37NO4 CHARGE: 0
name: tetradecadienoyl carnitine
initial amount: NaN
type: Species

metaM c4crn e
initial concentration: 1.0
name: butyryl carnitine
constant: false
type: Species
boundary condition: false
is: C02862
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
notes: FORMULA: C11H21NO4 CHARGE: 0
is: SBO:0000247

metaR ALAt2r
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
name: L-alanine reversible transport via proton symport
is: SBO:0000185
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000304

metaM ksi pre31 g
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 31
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00175
is: C00130

metaR HMGCOASim
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
product: MODEL1310110039#
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
fast: false
is: SBO:0000176
reversible: false

metaM gpi sig r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: Y CHARGE: 0
is: SBO:0000247
constant: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
type: Species
initial amount: NaN
is: HMDB00224
boundary condition: false
is: CHEBI:58190

http://identifiers.org/biomodels.db/MODEL1310110039#_4603502a_528b_4f83_871f_609fffd4ff15
is: SBO:0000252
initial concentration: NaN
type: Species
is: P35754
boundary condition: true
name: GLRX
constant: false
is encoded by: hsa:2745
initial amount: NaN
has only substance units: false

metaM 6pgl r
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: SBO:0000247
is: HMDB01127
is: CHEBI:57955
constant: false
initial amount: NaN
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR Q10H2e
name: transport of ubiquinol into lymph
reversible: true
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
type: Reaction
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR NDPK10
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM hs deg22 l
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: CHEBI:21338
notes: FORMULA: C37H56NO35S CHARGE: -3
is: HMDB02704

metaR CRNCARtp
is: SBO:0000185
reversible: false
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: carnitine-acetylcarnitine carrier, peroxisomal
kinetic law: MODEL1310110039#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b355dfe1_4269_4608_a881_3424d90f485b
initial concentration: NaN
name: ENTPD1
type: Species
is: Q86VV3
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:953
is: SBO:0000252

metaR FAOXC122x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b51c6001_501a_4c56_9008_d448c7b817a3
is encoded by: hsa:2585
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: GALK2
is: Q01415
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM acmana e
name: N-acetyl-D-mannosamine
is: SBO:0000247
is: CHEBI:17122
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01129
type: Species
boundary condition: false

metaM hs l
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
has only substance units: false
constant: false
is: CHEBI:28815
type: Species
name: heparan sulfate, free chain

metaR C4tmc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

metaR r0392
reversible: true
kinetic law: MODEL1310110039#
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_f82f291a_16fe_4b25_bdc6_6f6212558311
boundary condition: true
name: PKM2
initial amount: NaN
is: SBO:0000252
is: B4DNK4
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5315
constant: false

metaR ARAB Lt
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
name: L-arabinoase extracellular transport
product: MODEL1310110039#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_f627be7b_d227_4963_a8f4_f057eb9fa7e7
name: FTCD
is: O95954
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:10841
initial amount: NaN
constant: false
is: SBO:0000252

metaR EX c16dc
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_77dfe158_0301_466b_83d9_d828491d5156
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: B4E0V8
constant: false
is encoded by: hsa:3034
name: HAL
has only substance units: false

metaR DGK1
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
reactant: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110039#

metaR DHPM1
is described by: ECO:0000269
modifier: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
fast: false
reactant: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.2
name: dihydropyrimidinase (5,6-dihydrouracil)
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#

metaM dhcholestanate m
constant: false
initial concentration: 1.0
is: HMDB00359
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
is: CHEBI:16577
initial amount: NaN
is: SBO:0000247

metaM fmn c
constant: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: HMDB01520
name: FMN
is: C00061
is: CHEBI:58210
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b8bbe3a1_7073_4074_8f91_4b460742cf8b
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q5FWF5
name: ESCO1
is encoded by: hsa:114799

metaR KSItly
name: keratan sulfate I transport, extracellular to lysosome
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_50a931e8_e9a5_430a_89c6_1877e7931caa
constant: false
type: Species
is: Q14642
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: INPP5A
has only substance units: false
is encoded by: hsa:3632

metaR HS1ly
fast: false
name: heparan-N-sulfatase, lysosomal
product: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD

metaM c4crn c
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false
name: butyryl carnitine
is: SBO:0000247
initial amount: NaN
is: C02862
initial concentration: 1.0
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
is: HMDB02013

metaM cs e deg4 l
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15748
is: HMDB00127
notes: FORMULA: C31H46NO38S4 CHARGE: -5
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR ACGALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-galactosamine lysosomal efflux
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: false
product: MODEL1310110039#
is described by: ECO:0000000
fast: false

metaR r0656
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000176
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110039#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_f79ef19b_151e_4ba6_b1a8_a9e25a8fd04c
is encoded by: hsa:3939
is encoded by: hsa:3945
boundary condition: true
has part: P07195
is: SBO:0000297
name: LDHA:LDHB
has part: P00338
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaM pristcoa x
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:51341

metaM cgly e
is: SBO:0000247
is: HMDB00078
boundary condition: false
initial concentration: 1.0
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: CHEBI:4047
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR FACOAL1812
modifier: MODEL1310110039#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110039#
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110039#

metaR r0514
fast: false
kinetic law: MODEL1310110039#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reversible: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
is described by: ECO:0000000

metaR PRODt2r
name: D-proline reversible transport via proton symport
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is: SBO:0000185
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
fast: false
product: MODEL1310110039#
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_41981159_fd2a_4c5d_8daa_b4372ae57741
is encoded by: hsa:2271
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: P07954
initial concentration: NaN
constant: false
initial amount: NaN
name: FH

metaR r0394
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110039#
reversible: true
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110039#

metaR r0655
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
reversible: true
is: SBO:0000176
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction

metaM adrncoa c
name: adrenyl coenzyme A
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
is: C16170
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_b4bee436_7623_4971_8034_c6c4cb212846
constant: false
type: Species
boundary condition: true
name: SPTLC1
initial amount: NaN
is: O15269
is: SBO:0000252
is encoded by: hsa:10558
has only substance units: false
initial concentration: NaN

metaM ksii core4 deg2 l
constant: false
name: keratan sulfate II (core 4-linked), degradation product 2
boundary condition: false
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: CHEBI:12936

metaM coa x
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: Coenzyme A
is: C00010
is: CHEBI:57287
is: SBO:0000247
constant: false
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false

metaM dag hs r
initial amount: NaN
name: diglyceride
has only substance units: false
is: CHEBI:18035
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
constant: false

metaM HC01403 m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: CHEBI:28325
type: Species
constant: false
name: (S)-Hydroxydecanoyl-CoA

metaR FACOAL1813
type: Reaction
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR DAGt
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
name: diacylglycerol transport
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_55dcda8d_9311_4faf_9ee7_b57fa574ce11
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q9NS82
initial amount: NaN
type: Species
name: SLC7A10
is encoded by: hsa:56301
constant: false
has only substance units: false

metaR r0236
reversible: true
product: MODEL1310110039#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110039#
type: Reaction

metaM dhcholoylcoa x
has only substance units: false
is: HMDB06895
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
constant: false
boundary condition: false
is: CHEBI:27393
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0393
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR STS1
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: false
name: Steryl-sulfatase
is described by: ECO:0000269
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_9a1da291_a949_4081_9aed_13445aba013a
has only substance units: false
is: P47895
type: Species
constant: false
initial concentration: NaN
name: ALDH1A3
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:220

metaR FAOXC102C103x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR C4STMO2r
reversible: false
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is version of: http://identifiers.org/ec-code/1.14.13.72
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
name: C-4 methyl sterol oxidase

http://identifiers.org/biomodels.db/MODEL1310110039#_64dd19bd_c80c_4344_a261_f2233a88b73e
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:210
is: P13716
initial amount: NaN
type: Species
name: ALAD

http://identifiers.org/biomodels.db/MODEL1310110039#_457626b1_407e_4c77_8b89_2908dcec7f6c
boundary condition: true
is encoded by: hsa:223
constant: false
type: Species
is: P49189
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ALDH9A1
initial concentration: NaN

metaR biomass reaction
type: Reaction
kinetic law: MODEL1310110039#
name: biomass_reaction
reactant: MODEL1310110039#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110039#

metaR UMPK7
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110039#
name: UMP kinase (dGTP)
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
fast: false

metaR LPS3e
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
name: lipase, extracellular
reversible: false
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_72e0567f_3378_460d_b59a_1783fcfd2a06
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q8IYH3
is encoded by: hsa:3036
name: HAS1
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_4e97dd7f_75d5_460e_91d4_1f8d5e203e7e
is encoded by: hsa:10317
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: B3GALT5
constant: false

metaM ksi deg1 l
has only substance units: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
is: CHEBI:18287
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00174
type: Species

metaM c5dc e
is: HMDB13130
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C12H21NO6 CHARGE: 0
name: glutaryl carnitine
type: Species
boundary condition: false

metaR RE1796M
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
name: RE1796
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_c8d7e6ea_7581_4462_bd6a_7096c165ffa6
initial amount: NaN
name: PANK1
is encoded by: hsa:53354
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM 3mldz c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: 1-methylimidazole-4-acetaldehyde
is: SBO:0000247
boundary condition: false
is: CHEBI:28104
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
is: HMDB04181
has only substance units: false

metaR EX CE2916 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: neocasomorphin exchange
type: Reaction

metaR CYTK8n
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
name: cytidylate kinase (CMP,dATP),nuclear
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_19ee5425_3abd_40a0_b573_feac7ffc1e36
is encoded by: hsa:2747
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: GLUD2
has only substance units: false
constant: false
is: P49448
initial concentration: NaN

metaM retinal cis 13 r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 13-cis-retinal
initial concentration: 1.0
is: CHEBI:45487
is: HMDB06220
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8e9d858e_5e63_4210_847d_498833a8d2e1
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10317
has only substance units: false
is: SBO:0000252
name: B3GALT5
constant: false
initial concentration: NaN

metaR FAOXC122m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_f392bad5_6e9a_4165_83d1_b22f8cf64e6b
has only substance units: false
boundary condition: true
constant: false
name: SMS
type: Species
is: P52788
is encoded by: hsa:6611
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR FAOXC5C5OHm
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_4dcba13e_6d5e_40cb_af4e_4ba0793ab5fb
constant: false
initial amount: NaN
is encoded by: hsa:124935
type: Species
boundary condition: true
name: SLC43A2
is: SBO:0000252
is: Q8N370
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8ebfcee1_3b91_4758_8282_81a69cf0e43e
is: Q9H0P0
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51251
name: NT5C3

metaM acmana c
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
type: Species
is: CHEBI:17122
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: N-acetyl-D-mannosamine
is: HMDB01129
constant: false

metaM Lpipecol x
type: Species
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
constant: false
is: CHEBI:30913
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: L-pipecolic acid
initial concentration: 1.0
is: HMDB00716
boundary condition: false

metaR KCC2t
is: SBO:0000185
name: K+-Cl- cotransporter (NH4+)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
product: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_ad79edb5_5a6d_415a_b9fc_bf53c94122e5
is encoded by: hsa:7359
has only substance units: false
constant: false
type: Species
name: _7359_1_c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM stcrn c
initial concentration: 1.0
has only substance units: false
is: HMDB00848
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: stearoylcarnitine
constant: false

metaR UMPK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110039#
type: Reaction
fast: false
product: MODEL1310110039#
reversible: true
name: UMP kinase (dATP)
is described by: ECO:0000269
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110039#
is: SBO:0000176

metaR MM8Cg
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
fast: false

metaR r1010
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110039#
type: Reaction
fast: false
product: MODEL1310110039#

metaR ADK3
product: MODEL1310110039#
name: adentylate kinase (GTP)
type: Reaction
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_43ae294b_cc4c_4439_b244_5f10200a9dc5
is: SBO:0000252
is: P17752
type: Species
boundary condition: true
name: TPH1
is encoded by: hsa:7166
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM c5dc c
is: HMDB13130
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
name: glutaryl carnitine
initial concentration: 1.0
notes: FORMULA: C12H21NO6 CHARGE: 0

metaM arachcrn c
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB06460
initial concentration: 1.0
name: arachidyl carnitine
constant: false

metaM prostgi2 e
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: prostaglandin I2(1-)
constant: false
boundary condition: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
is: CHEBI:57403

metaM pacald c
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: HMDB06236
is: SBO:0000247
constant: false
is: CHEBI:16424
has only substance units: false
boundary condition: false
name: phenylacetaldehyde

metaR UMPK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
reactant: MODEL1310110039#
name: UMP kinase (dCTP)
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#

metaR r0517
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

metaR HXPRT
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM ksi pre6 g
is: C00130
type: Species
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 6
notes: FORMULA: C107H174N7O80SX CHARGE: -2
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58053

metaM ptdcacrn c
name: pendtadenoyl carnitine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01721
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: CHEBI:15811
type: Species
constant: false

metaR CHSTEROLt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110039#
name: cholesterol intracellular transport
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
fast: false
type: Reaction
is: SBO:0000185

metaR r1433
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: false
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
kinetic law: MODEL1310110039#

metaR FAOXC163C164Gm
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM tetdec2crn c
has only substance units: false
boundary condition: false
is: HMDB02014
initial amount: NaN
constant: false
name: tetradecadienoyl carnitine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species

metaR NCNt
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110039#
name: Na+/Ca2+-NH4+ exchange
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
fast: false

metaM CE2705 c
has only substance units: false
is: CHEBI:36781
initial concentration: 1.0
constant: false
name: quinonoid dihydrobiopterin
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_5dc638d5_2688_4840_bb15_b9d12fd7bd18
is: SBO:0000252
constant: false
has only substance units: false
name: COX4I2
is encoded by: hsa:84701
initial concentration: NaN
type: Species
is: Q96KJ9
boundary condition: true
initial amount: NaN

metaR r2098
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110039#
product: MODEL1310110039#

metaM gdp c
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial concentration: 1.0
type: Species
is: C00035
initial amount: NaN
is: CHEBI:58189
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_eca1b754_2375_4d6d_ae63_dfe1f1752709
is: Q9UJ70
constant: false
name: NAGK
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:55577
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR G14T21g
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110039#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_3a31af62_daf2_4019_a07f_9fd7cb3a0be1
boundary condition: true
has only substance units: false
is encoded by: hsa:9469
type: Species
name: CHST3
is: Q7LGC8
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_c84cd532_3060_46a5_a5ab_349c7e647f68
initial amount: NaN
is: Q8NB10
name: PDE1C
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5137
has only substance units: false

metaR ADK1
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
name: adenylate kinase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_69a9c054_4cb9_46e5_96b9_cebd360e1967
is encoded by: hsa:4720
has only substance units: false
is: B7Z792
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: NDUFS2

metaM mescoa m
initial concentration: 1.0
is: C06028
has only substance units: false
is: CHEBI:27969
boundary condition: false
initial amount: NaN
type: Species
name: Mesaconyl-CoA
is: SBO:0000247
constant: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110039#_233165c2_b113_44ec_bbbd_a7c232b688d2
name: _AA532636_1_m
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA532636
initial concentration: NaN
constant: false
boundary condition: true

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM coa r
type: Species
constant: false
is: CHEBI:57287
name: Coenzyme A
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
has only substance units: false
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110039#_fd819af7_ddaf_4619_b05a_121bbde1af44
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5631
name: PRPS1
is: P60891
type: Species
has only substance units: false

metaR r2099
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM prostgi2 c
initial concentration: 1.0
has only substance units: false
is: CHEBI:57403
name: prostaglandin I2(1-)
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
is: SBO:0000247

metaR LNLCCPT2
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110039#
fast: false
name: carnitine transferase
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR RBK
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.15
is described by: ECO:0000304
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: ribokinase

metaM dhcholestanate c
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
is: HMDB00359
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
is: CHEBI:16577
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_2c26e0f8_6161_4dc0_939a_8f01fe9e164e
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: Q9NY65

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR KSIt
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: keratan sulfate I transport, golgi to extracellular
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
fast: false
is: SBO:0000185

metaM HC02202 c
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
initial amount: NaN
name: prostaglandin A1(1-)
has only substance units: false
type: Species
is: CHEBI:57398

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_622fcf56_8e38_4f8a_89d3_ff8658c113fe
is encoded by: hsa:2683
initial amount: NaN
name: B4GALT1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
is: P15291

metaM HC01162 c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: CHEBI:58376
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial amount: NaN
type: Species

metaR r2096
reversible: true
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110039#
name: carnitine O-palmitoyltransferase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_7e0efb0a_e7cb_4a72_9907_73a0d03efb5b
is: E9PB82
is: SBO:0000252
boundary condition: true
type: Species
name: HSD17B4
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:3295
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_cc81ca83_5bfa_4c10_b9db_ebb631d29918
initial amount: NaN
name: OXSM
constant: false
initial concentration: NaN
is: Q9NWU1
is encoded by: hsa:54995
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR FACOAL80i
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (octanoate)
kinetic law: MODEL1310110039#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3

metaR CHSTEROLt2
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol intracellular transport
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#

metaR r1434
name: Transport reaction
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_f48574bd_f98d_400a_81ee_e56648b66f9b
is: P46926
is: SBO:0000252
is encoded by: hsa:10007
boundary condition: true
name: GNPDA1
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR FAOXC143C123m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_3ca5a925_06d5_4656_8365_fa621ffa2115
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:513
type: Species
has only substance units: false
name: ATP5D

metaM pglyc hs c
type: Species
is: SBO:0000247
is: CHEBI:21338
name: pglyc_hs[c]
initial amount: NaN
notes: FORMULA: CHARGE: 0
constant: false
is: HMDB02704
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r2097
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
type: Reaction

metaR RE3567C
type: Reaction
product: MODEL1310110039#
is: SBO:0000176
reversible: true
name: RE3567
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_773f9a37_1af4_4720_9d4e_13ee811e44b4
is: B3KWF4
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: GALNT11
is encoded by: hsa:63917

http://identifiers.org/biomodels.db/MODEL1310110039#_f2fa7266_2df0_4075_9aa7_64fe63df8ebe
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q5SYN6
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC22A3
is encoded by: hsa:6581
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_b930d81f_d356_4064_aca1_dc0ea7cacd55
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _AI222095_1_m
is encoded by: hsa:AI222095

metaR MANtly
fast: false
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
is: SBO:0000185
name: mannose efflux from lysosome

metaM dump c
type: Species
is: HMDB01409
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: C00365
is: SBO:0000247
is: CHEBI:246422
name: dUMP
has only substance units: false
boundary condition: false

metaM accoa r
type: Species
is: HMDB01206
has only substance units: false
is: CHEBI:57288
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
name: acetyl-CoA(4-)
initial amount: NaN

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR r1609
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
type: Reaction
fast: false
reversible: true

metaM dgsn c
boundary condition: false
is: C00330
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
is: HMDB00085
is: SBO:0000247
initial amount: NaN
is: CHEBI:17172
type: Species
name: Deoxyguanosine
initial concentration: 1.0

metaR r0796
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_7b586c74_8fc8_4e7f_93d2_516eb7ddb940
boundary condition: true
constant: false
name: EGFR
initial concentration: NaN
is: P00533
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1956
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_c1c519ee_c07f_43e0_802a_977605a994f9
initial concentration: NaN
is: Q9NUB1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:84532
name: ACSS1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_786c8e8e_baaa_4836_b570_c3dfef8beffa
boundary condition: true
initial concentration: NaN
type: Species
is: P14555
constant: false
is encoded by: hsa:5320
name: PLA2G2A
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM dhdascb e
is: CHEBI:58070
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01264
is: SBO:0000247
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false
name: dehydroascorbide(1-)

metaR NOt
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is described by: ECO:0000000
fast: false
type: Reaction
name: NO transport (diffusion)
reactant: MODEL1310110039#

metaM gd3 hs g
has only substance units: false
name: GD3
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
is: CHEBI:28424
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR r1608
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_74a7876d_626b_4849_9461_f777ebd90250
type: Species
boundary condition: true
initial concentration: NaN
name: _LOC728997_1_c
is encoded by: hsa:LOC728997
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

metaR C5DCe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM dag hs c
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: diglyceride
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r0797
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
name: glycine N-choloyltransferase EC:2.3.1.65
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:

metaM dmnoncrn c
type: Species
is: HMDB06202
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110039#_0b97012d_cae4_449c_95bc_be04619f7334
has only substance units: false
is: Q96KH8
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC6A2
is encoded by: hsa:6530
boundary condition: true

metaR ILEtec
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
reversible: true
name: L-isoleucine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false

metaR PIter
kinetic law: MODEL1310110039#
name: phosphate transport, endoplasmic reticulum
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000212
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110039#

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM asn L c
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:17196
is: HMDB00168
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine

metaR KYNAKGAT
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
fast: false
is described by: ECO:0000269
name: L-Kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaM 6hoxmelatn c
is: http://identifiers.org/pubchem.compound/7954
has only substance units: false
is: C05643
boundary condition: false
is: HMDB04081
initial amount: NaN
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 6-Hydroxymelatonin
type: Species

metaR PCRNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
name: transport into the mitochondria from cytosol (carnitine)
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_64c1dcf0_b07d_4054_ac8f_af5135444564
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9UEF7
constant: false
is encoded by: hsa:9365
name: KL

metaR RETFA
name: retinol acyltransferase
reactant: MODEL1310110039#
fast: false
is: SBO:0000176
product: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
type: Reaction

metaR HISD
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: histidase
reversible: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.1.3
fast: false
is: SBO:0000176

metaR r0812
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
kinetic law: MODEL1310110039#
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110039#

metaR r1607
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r1428
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
name: Free diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000

metaM atp r
boundary condition: false
is: CHEBI:57299
constant: false
initial amount: NaN
is: HMDB00538
initial concentration: 1.0
name: ATP(4-)
is: SBO:0000247
is: C00002
type: Species
has only substance units: false

metaM pyr m
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: C00022
name: pyruvate
is: CHEBI:15361
boundary condition: false
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_702c38c4_51e3_412f_8d0d_f44cbe07c4ba
is: Q53H96
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: PYCRL
is encoded by: hsa:65263

metaM mpdol U c
is: CHEBI:18396
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20

metaM m4mpdol U r
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37633

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_938be307_820a_42b3_b798_0ededf08966d
is: B2RDU6
name: MVK
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4598
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaR NaKt
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.9
type: Reaction
reversible: false
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000269
fast: false
name: Na+/K+ exchanging ATPase
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
reactant: MODEL1310110039#

metaR MDHx
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
fast: false
name: malate dehydrogenase, peroxisomal
is described by: ECO:0000134

metaR r0813
kinetic law: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
is: SBO:0000185

metaR FMNAT
is: SBO:0000176
reversible: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.7.2
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
name: FMN adenylyltransferase
product: MODEL1310110039#

metaR 3DSPHR
name: 3-Dehydrosphinganine reductase
reversible: false
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.102
fast: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#

metaR r1429
name: Free diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
reversible: true
fast: false

metaR r1606
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_b301a7a9_a479_465e_94f7_1380c182f1b2
has only substance units: false
type: Species
is: SBO:0000252
is: Q9P109
name: GCNT4
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51301

metaM c3dc c
type: Species
is: SBO:0000247
is: HMDB02095
name: malonyl carnitine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C10H16NO6 CHARGE: -1

metaM asn L e
name: L-asparagine
is: CHEBI:17196
initial concentration: 1.0
is: HMDB00168
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR r0791
kinetic law: MODEL1310110039#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000

metaM Lcystin c
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00192
constant: false
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
has only substance units: false
initial amount: NaN
boundary condition: false

metaR FAOXC184C164x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR L LACt2r
reactant: MODEL1310110039#
name: L-lactate reversible transport via proton symport
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR B MANNASEly
reactant: MODEL1310110039#
name: beta-mannosidase, lysosomal
modifier: MODEL1310110039#
type: Reaction
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.25

metaR BILIRUBtr
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110039#
is: SBO:0000185

metaM atp x
has only substance units: false
boundary condition: false
is: C00002
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
name: ATP(4-)
is: HMDB00538

metaR CEPTE
reversible: false
name: ethanolamine phosphotransferase
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110039#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.2
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110039#_907e205e_7d69_4093_9e4a_2ff9948e3f6d
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: O75874
initial concentration: NaN
name: IDH1
is encoded by: hsa:3417

metaR LALDO2x
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
fast: false

metaM odecoa c
is: CHEBI:3793
is: HMDB01322
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
initial amount: NaN

metaR r0792
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
type: Reaction
is described by: ECO:0000000
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR RE2799C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is: SBO:0000176
name: RE2799
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_aeaeeaef_7c68_40ec_8ca9_a53d361fd842
constant: false
initial concentration: NaN
is encoded by: hsa:4830
is encoded by: hsa:4831
type: Species
has only substance units: false
is: SBO:0000297
boundary condition: true
has part: P22392
name: NME1:NME2
initial amount: NaN
has part: P15531

metaR PROSTGF2t
reversible: true
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
name: prostaglandin uniport
fast: false
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000269

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaM h2o2 m
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: CHEBI:16240
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: Hydrogen peroxide
has only substance units: false
is: HMDB03125

metaR GALASE10ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
product: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110039#_538ee8bf_1620_4d24_934b_ddb56b688c0f
is: SBO:0000252
boundary condition: true
is: O95168
type: Species
is encoded by: hsa:4710
has only substance units: false
constant: false
name: NDUFB4
initial concentration: NaN
initial amount: NaN

metaM thcrm hs g
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:24636
type: Species
initial amount: NaN
is: SBO:0000247
name: trihexosyl ceramide

http://identifiers.org/biomodels.db/MODEL1310110039#_98571352_58e1_4ce7_9174_09e2fa2b0b58
is encoded by: hsa:3157
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: HMGCS1
has only substance units: false
initial amount: NaN

metaR r0680
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110039#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_466ebfb2_6ef4_4b1c_a6ee_a46ef552c7be
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: B3KNC1
is: SBO:0000252
is encoded by: hsa:51733
type: Species
constant: false
name: UPB1

http://identifiers.org/biomodels.db/MODEL1310110039#_5a3d205d_7b46_4f6b_b8b8_ce7f4cd34327
constant: false
initial amount: NaN
boundary condition: true
is: Q7Z4W1
initial concentration: NaN
type: Species
is encoded by: hsa:51181
is: SBO:0000252
has only substance units: false
name: DCXR

metaM glx c
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00119
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_ba11c331_9845_49fc_9506_095660d996ee
is encoded by: hsa:4846
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: A0S0A7
name: NOS3
has only substance units: false
is: SBO:0000252

metaM accoa x
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: C00024
name: Acetyl-CoA
initial concentration: 1.0
has only substance units: false
is: HMDB01206
boundary condition: false

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r1756
product: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_77ba6dba_e445_4e32_a736_1dbef679de58
name: PKLR
constant: false
is encoded by: hsa:5313
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM Lcystin e
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00192
is: CHEBI:16283
initial amount: NaN
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
boundary condition: false

metaM 6pgl c
initial amount: NaN
constant: false
is: C01236
is: CHEBI:57955
notes: FORMULA: C6H9O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01127
name: 6-phospho-D-glucono-1,5-lactone
initial concentration: 1.0
boundary condition: false

metaM 5tedtricoa x
is: HMDB02288
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
name: 5,8,11-tetradecatrienoylcoa
has only substance units: false

metaM h2o2 n
boundary condition: false
name: hydrogen peroxide
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16240
is: HMDB03125
initial amount: NaN
constant: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaR NACHEX26ly
is: SBO:0000176
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
type: Reaction
kinetic law: MODEL1310110039#
name: beta-N-acetylhexosaminidase, lysosomal

metaM itaccoa m
name: itaconyl-CoA(5-)
is: HMDB03377
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57381

metaM dhdascb c
is: HMDB01264
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
type: Species
is: SBO:0000247
name: dehydroascorbide(1-)
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58070

metaR PHEACGLNt
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
name: PHEACGLN extracellular transport via diffusion

metaR ADRNt
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_606211d9_18ca_4e88_b532_b03c1261b353
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: Q96BD0
boundary condition: true
is: SBO:0000252
is encoded by: hsa:28231
name: SLCO4A1
has only substance units: false

metaR NACHEXA13ly
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#

metaM aacoa c
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
is: HMDB01484
initial concentration: 1.0
name: Acetoacetyl-CoA
constant: false
is: CHEBI:57286
is: C00332
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_71d61774_249d_4147_aa0b_e166389838b3
constant: false
name: ALG3
initial amount: NaN
is encoded by: hsa:10195
is: SBO:0000252
is: Q92685
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM acgal l
constant: false
name: N-acetyl-D-galactosamine
is: HMDB00212
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28037

metaR FAOXC16080m
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_1fe77dd9_52d8_4169_ad06_360e535e2540
initial concentration: NaN
boundary condition: true
name: ALG5
is: Q9Y673
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:29880
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_51f79cd4_a571_445e_91ee_f51723744f36
initial amount: NaN
has only substance units: false
is: Q9UIG8
constant: false
type: Species
is encoded by: hsa:28232
name: SLCO3A1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_c45f7e52_7a14_404a_8d7a_b3dd5a555541
name: SLC34A2
type: Species
is encoded by: hsa:10568
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: O95436
has only substance units: false
initial amount: NaN
constant: false

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR GLNALANaEx
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
reversible: false
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)
reactant: MODEL1310110039#
is described by: ECO:0000269

metaM pchol hs m
has only substance units: false
constant: false
initial concentration: 1.0
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
is: CHEBI:16110
type: Species
initial amount: NaN
boundary condition: false

metaR H2O2t
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: hydrogen peroxide transport via diffusion
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_d328a481_a77a_4c5c_a42b_a4ab02866566
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6521
is: P02730
name: SLC4A1
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR RE2349C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
name: RE2349
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM gm3 hs g
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:60065
is: SBO:0000247
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
constant: false
initial amount: NaN
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730

http://identifiers.org/biomodels.db/MODEL1310110039#_98381834_d9ec_4f14_a0f5_8347b946a332
boundary condition: true
initial amount: NaN
is encoded by: hsa:D87002
name: _D87002_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_cffebdbc_5e09_485a_aba7_545dd66f4b92
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: SLC2A14
has only substance units: false
is: Q8TDB8
initial amount: NaN
is encoded by: hsa:144195
boundary condition: true

metaM Rtotal e
is: C00255
is: CHEBI:3554
initial amount: NaN
name: R total
constant: false
is: HMDB00244
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0045a317_ce1d_4908_8184_0d71c698a17c
is encoded by: hsa:93010
has only substance units: false
name: B3GNT7
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: Q8NFL0

http://identifiers.org/biomodels.db/MODEL1310110039#_288144af_f47f_4a70_bbe4_aa45b5d7d257
is encoded by: hsa:18
name: ABAT
constant: false
initial amount: NaN
has only substance units: false
is: P80404
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM dmnoncoa c
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
initial amount: NaN
is: HMDB11604
constant: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaM Rtotal2 c
is: HMDB01564
name: R total 2 position
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57876

metaM hmbil c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
is: C01024
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57845
name: Hydroxymethylbilane
initial concentration: 1.0
constant: false
is: HMDB01137

http://identifiers.org/biomodels.db/MODEL1310110039#_df7720f9_d5dd_4c9b_bef7_98582581ff74
boundary condition: true
is encoded by: hsa:51179
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: HAO2

metaM gacpail hs c
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
is: C01236
is: CHEBI:57955
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: HMDB01127
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_50137537_4847_4e06_9dea_6818367a286f
constant: false
is: SBO:0000252
has only substance units: false
name: NDUFB2
is: H7C5B8
initial concentration: NaN
is encoded by: hsa:4708
initial amount: NaN
boundary condition: true
type: Species

metaR PI3P3Pn
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:EC 3.1.3.- NCD
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
reversible: false
name: phosphatidylinositol-3-phosphate 3-phosphatase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110039#_24a15f4c_7da5_4e3d_96da_e4869ff582e0
is: O76082
is: SBO:0000252
name: SLC22A5
has only substance units: false
constant: false
type: Species
is encoded by: hsa:6584
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR OMPDC
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
modifier: MODEL1310110039#
is described by: ECO:0000269
fast: false
reversible: false
name: orotidine-5'-phosphate decarboxylase
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
type: Reaction

metaR r0683
is described by: ECO:0000000
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reactant: MODEL1310110039#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e648a26c_8f5b_4718_95de_aa17e0e6a925
boundary condition: true
initial concentration: NaN
name: PYCR1
initial amount: NaN
is encoded by: hsa:5831
constant: false
type: Species
has only substance units: false
is: P32322
is: SBO:0000252

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: hydrogen cyanide
is: CHEBI:18407
is: SBO:0000247
is: HMDB02084
has only substance units: false

metaR r1600
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GALASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaM odecoa m
has only substance units: false
is: CHEBI:57387
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: HMDB01322
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
type: Species

metaR SPODMx
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110039#
fast: false
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
name: superoxide dismutase, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110039#_c44d8398_f73d_45df_b1ab_57dfa5000468
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NS18
name: GLRX2
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51022
initial amount: NaN

metaM dump m
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:246422
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01409
name: dUMP(2-)

metaM pail34p hs c
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
is: CHEBI:57658
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR OCTDECCACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR ACONT
kinetic law: MODEL1310110039#
name: aconitase
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110039#
reversible: true
is described by: ECO:0000134

metaR FAOXC4C2m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C4-->C2)m
type: Reaction

metaR S6T18g
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110039#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
fast: false
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_60e91dae_edfe_41db_9481_b17bef06b039
boundary condition: true
initial amount: NaN
is encoded by: hsa:1808
constant: false
is: SBO:0000252
initial concentration: NaN
name: DPYSL2
type: Species
is: B4DR31
has only substance units: false

metaM elaidcrn c
constant: false
type: Species
name: Elaidic carnitine
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB06464
boundary condition: false

metaM dolp U c
name: dolichyl phosphate(2-)
initial amount: NaN
constant: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM CE5162 r
boundary condition: false
name: trans,cis-2,9-octadecadienoyl-CoA
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57923
type: Species

metaR Htr
reactant: MODEL1310110039#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
name: H transporter, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM dump n
name: dUMP(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409
constant: false
type: Species
boundary condition: false
is: CHEBI:246422

http://identifiers.org/biomodels.db/MODEL1310110039#_a8ff3a84_b8f9_4f5a_8d32_4339cabc750d
has only substance units: false
name: SLC19A3
boundary condition: true
is: Q9BZV2
initial concentration: NaN
is encoded by: hsa:80704
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaR FADH2tru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
name: FADH2 transporter, endoplasmic reticulum
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: false
product: MODEL1310110039#
is: SBO:0000185
fast: false

metaM nm2masn g
initial amount: NaN
is: C05884
is: SBO:0000247
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
boundary condition: false
constant: false
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
has only substance units: false
initial concentration: 1.0

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaM pyr e
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
is: SBO:0000247
initial amount: NaN
is: CHEBI:15361
constant: false

metaM cyan e
constant: false
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
boundary condition: false
is: CHEBI:18407
initial concentration: 1.0
is: HMDB02084
name: hydrogen cyanide
has only substance units: false
initial amount: NaN

metaR FAOXC180
is: SBO:0000176
modifier: MODEL1310110039#
reversible: false
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
fast: false
is described by: ECO:0000269

metaM CE2424 m
initial amount: NaN
is: CHEBI:28387
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
boundary condition: false
has only substance units: false
is: HMDB11123
is: SBO:0000247
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
type: Species
initial concentration: 1.0

metaM 2hexdtetcoa m
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

metaM dgsn m
name: Deoxyguanosine
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17172
is: C00330
constant: false
is: HMDB00085
initial amount: NaN

metaM l2n2m2mn l
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
is: CHEBI:12936
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
type: Species
initial amount: NaN
is: HMDB00143
initial concentration: 1.0

metaR r1605
reversible: true
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_c6c99f6d_4aaf_42d8_841e_1d7a7f0dec78
has only substance units: false
type: Species
is: Q9Y259
is encoded by: hsa:1120
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: CHKB
initial concentration: NaN

metaR LPCOXp
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.5.3.1
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
type: Reaction
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
name: L-pipecolate oxidase, peroxisomal

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6d23e651_036a_48e3_9237_bb96b8e4db90
constant: false
has part: O95498
is encoded by: hsa:55350
boundary condition: true
is encoded by: hsa:8875
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000297
type: Species
name: VNN3:VNN2:VNN1

metaR LPCHOLt
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
name: lysophosphatidylcholine transport
is described by: ECO:0000000
fast: false
product: MODEL1310110039#
is: SBO:0000185

metaM leuktrE4 e
initial amount: NaN
is: HMDB02200
type: Species
name: leukotriene E4(1-)
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1b289045_3363_4de8_963e_9c0f47fb3f39
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: B3GALNT1
type: Species
initial concentration: NaN
is: Q49AT3
is encoded by: hsa:8706

metaR HACD9m
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
type: Reaction
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR HEXDICOAACBP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR PSFLIPm
modifier: MODEL1310110039#
reversible: false
name: phosphatidylserine flippase
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.6.3.1
is: SBO:0000185
type: Reaction

metaM dodecanac c
type: Species
constant: false
initial concentration: 1.0
is: HMDB00623
name: Dodecanedioic acid
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H20O4 CHARGE: -2

metaM accoa n
initial concentration: 1.0
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
has only substance units: false
type: Species
is: SBO:0000247
name: acetyl-CoA(4-)
initial amount: NaN
is: CHEBI:57288
boundary condition: false

metaR CYTDK2m
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
type: Reaction
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
name: cytidine kinase (ATP), mitochondrial
product: MODEL1310110039#

metaM h2o2 c
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: HMDB03125
boundary condition: false
is: C00027
initial amount: NaN
type: Species

metaM tetdecdicoa x
boundary condition: false
is: HMDB02288
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false
constant: false
name: 5,8-tetradecadienoylcoa
initial concentration: 1.0

metaR r0686
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction

metaM ksi deg8 l
type: Species
is: CHEBI:12936
name: keratan sulfate I, degradation product 8
is: HMDB00143
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
has only substance units: false
initial concentration: 1.0

metaM ksi pre14 g
boundary condition: false
is: CHEBI:28067
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 14
constant: false

metaR CHOLATEt
name: cholate transport via bicarbonate countertransport
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110039#
fast: false

metaM dag hs e
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:18035
has only substance units: false
is: SBO:0000247
name: diglyceride
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaR LINKDEG3ly
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110039#
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal

metaR 5AOPtm
fast: false
name: 5-Aminolevulinate mitochondrial transport
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
reversible: true
is described by: ECO:0000134

metaR DNDPt9m
product: MODEL1310110039#
reversible: false
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000185
name: dADP transport via dTDP antiport
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110039#_869f6f7d_a804_45e5_8d79_7516420dbfa5
name: SLC26A4
boundary condition: true
constant: false
is: O43511
is: SBO:0000252
is encoded by: hsa:5172
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaR r1604
is: SBO:0000185
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR GGLUCT
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
type: Reaction
is: SBO:0000185
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.2.4
kinetic law: MODEL1310110039#
name: gamma-glutamylcyclotransferase
modifier: MODEL1310110039#

metaR CHOLK
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.32
name: Choline kinase
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000269
fast: false
reversible: false

metaM h2o2 e
boundary condition: false
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: hydrogen peroxide
is: HMDB03125
initial amount: NaN
constant: false
type: Species
is: CHEBI:16240
is: SBO:0000247
initial concentration: 1.0

metaM asn L m
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17196
boundary condition: false
is: HMDB00168
has only substance units: false
constant: false

metaR ADKd
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: adenylate kinase (d form)
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
product: MODEL1310110039#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f00df982_8eab_40b7_9a1d_671f557ba3cb
is: P78356
initial concentration: NaN
name: PIP4K2B
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:8396
constant: false

metaM 7dhchsterol r
boundary condition: false
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
constant: false
type: Species
is: CHEBI:17759
initial amount: NaN
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
initial concentration: 1.0

metaM glu L e
initial concentration: 1.0
is: CHEBI:29985
is: HMDB00148
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
type: Species
name: L-glutamate(1-)
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3437a436_d60c_4742_a5b3_3acb09a0df3c
is: Q86YU0
constant: false
has only substance units: false
name: CA7
is encoded by: hsa:766
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM accoa m
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01206
is: CHEBI:57288
name: Acetyl-CoA
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024

metaM pchol hs c
initial amount: NaN
is: SBO:0000247
name: Phosphatidylcholine
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
type: Species
is: CHEBI:16110

metaR OROTGLUt
reactant: MODEL1310110039#
is described by: ECO:0000134
fast: false
type: Reaction
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110039#
is: SBO:0000185
name: OROTGLUt

metaM anth e
initial amount: NaN
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
type: Species
is: SBO:0000247
has only substance units: false
name: anthranilate
constant: false
is: HMDB01123
is: CHEBI:16567
boundary condition: false
initial concentration: 1.0

metaM ksii core4 pre8 g
boundary condition: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
constant: false
type: Species
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: CHEBI:58053
is: C00130

metaR SIAASE2ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110039#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110039#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c7827ed0_f3a9_4196_b230_17e2677a2801
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: _AA629629_1_m
is encoded by: hsa:AA629629

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false
reversible: false
name: Sphingosine-1-phosphate lyase
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
is described by: ECO:0000304
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

metaM nrvnccoa c
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
name: nervonyl coenzyme A
is: SBO:0000247
has only substance units: false
is: C16532
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM dmpp x
is: HMDB01120
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57623
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
type: Species
boundary condition: false
name: prenyl diphosphate(3-)
constant: false

metaM dgmp c
constant: false
is: C00362
initial concentration: 1.0
is: CHEBI:57673
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01044
name: dGMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
initial amount: NaN

metaM leuktrE4 c
boundary condition: false
name: leukotriene E4(1-)
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_cfd10e5b_5706_40d4_a846_4f89939759a7
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:9374
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9UMR5
name: PPT2

metaM Rtotal c
is: HMDB01448
initial amount: NaN
boundary condition: false
name: R total
constant: false
initial concentration: 1.0
is: CHEBI:16189
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
type: Species
has only substance units: false

metaM acgal c
is: SBO:0000247
boundary condition: false
type: Species
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: CHEBI:28037
has only substance units: false
is: HMDB00212
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r0688
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
fast: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reactant: MODEL1310110039#

metaR Htx
type: Reaction
product: MODEL1310110039#
name: H transporter, peroxisome
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000

metaR r1603
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_e4fe9ba4_6ce2_4df5_8f5d_5e9ae9a01e52
is: Q96C36
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29920
name: PYCR2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_a0c58b46_1194_4976_9b3c_688a40f696f7
boundary condition: true
constant: false
is: O00476
is: SBO:0000252
name: SLC17A3
has only substance units: false
is encoded by: hsa:10786
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_a8b0015f_2889_4281_aeb8_f64e77379640
is encoded by: hsa:AA854479
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AA854479_1_m

metaM glu L c
initial concentration: 1.0
is: CHEBI:29985
is: HMDB00148
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM Rtotal2 e
name: R total 2 position
boundary condition: false
is: CHEBI:3554
is: C00255
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00244
type: Species
notes: FORMULA: CO2FULLR2 CHARGE: -1

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaM pchol hs e
is: CHEBI:16110
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: Phosphatidylcholine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaM C04849 e
initial amount: NaN
is: CHEBI:57449
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
type: Species

metaM pdx5p c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
is: HMDB01319
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:58589
constant: false
initial concentration: 1.0
name: Pyridoxine 5'-phosphate
is: C00627

metaR r1602
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
fast: false

metaM acmana r
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17122
has only substance units: false
constant: false
is: HMDB01129

metaM anth c
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: anthranilate
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: HMDB01123
has only substance units: false
type: Species
initial concentration: 1.0

metaR FACOAL205
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR NAHCO3 HCLt
reversible: true
product: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
name: bicarbonate transport (HCl/NaHCO3 exchange)
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110039#

metaM oagt3 hs c
is: HMDB01514
has only substance units: false
name: 9-O-Acetylated GT3
constant: false
type: Species
is: C00329
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
initial amount: NaN
is: SBO:0000247
is: CHEBI:17315
initial concentration: 1.0
boundary condition: false

metaR THRD L
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
is described by: ECO:0000269
name: L-threonine deaminase
is version of: http://identifiers.org/ec-code/4.3.1.17
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false
reactant: MODEL1310110039#
type: Reaction

metaR PI45PLC
is: SBO:0000176
reactant: MODEL1310110039#
reversible: false
type: Reaction
kinetic law: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110039#

metaM idour e
initial amount: NaN
name: L-iduronate
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
has only substance units: false
is: HMDB02704
constant: false
is: CHEBI:21338
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_c79d5001_26e6_49ce_b66d_0e0e6bb213b2
is encoded by: hsa:204
is: P54819
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: AK2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_6bdd2b57_1ae6_46b7_b113_d7c9b328f415
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:218
initial amount: NaN
name: ALDH3A1
is: P30838
is: SBO:0000252
type: Species
initial concentration: NaN

metaM biliverd c
constant: false
initial amount: NaN
type: Species
is: CHEBI:57991
boundary condition: false
is: HMDB01008
is: SBO:0000247
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial concentration: 1.0
has only substance units: false
name: biliverdin(2-)

metaR SUCCACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_c32dee47_4278_42e1_97f1_e9ef3d358a19
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:7360
initial amount: NaN
is: SBO:0000252
name: UGP2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_4c1d78e0_4fd2_43ab_9d59_7577020e70fa
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AI818585
initial concentration: NaN
initial amount: NaN
name: _AI818585_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e2486d77_0bd3_425e_9d5f_f5f67bd97db9
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:10846
initial amount: NaN
is: Q9Y233
name: PDE10A
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3045e662_e0b5_476e_ba0b_c590f3b7cbe0
is: SBO:0000252
initial amount: NaN
is: Q8TE04
initial concentration: NaN
constant: false
has only substance units: false
name: PANK1
is encoded by: hsa:53354
type: Species
boundary condition: true

metaM aacoa m
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
name: acetoacetyl-CoA(4-)
is: HMDB01484
initial amount: NaN
constant: false
is: CHEBI:57286
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM tetdecdicoa m
boundary condition: false
name: 5,8-tetradecadienoylcoa
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false

metaR FAOXC184C164m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR r1318
reversible: true
type: Reaction
product: MODEL1310110039#
fast: false
name: Transport reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR PI5P3K
name: phosphatidylinositol-5-phosphate 3-kinase
is: SBO:0000176
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
modifier: MODEL1310110039#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.153
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD

metaR r0224
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: false
type: Reaction
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
product: MODEL1310110039#
modifier: MODEL1310110039#

metaM dgmp e
is: HMDB01044
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
name: dGMP(2-)
is: CHEBI:57673

http://identifiers.org/biomodels.db/MODEL1310110039#_d6dae0f6_acb9_4480_ac04_c252cde7932c
is encoded by: hsa:23600
name: AMACR
is: SBO:0000252
is: Q3KT79
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_5c2990a3_985b_48e6_898b_885bf9ecf93d
is: P15531
initial amount: NaN
name: NME1
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4830
initial concentration: NaN
has only substance units: false

metaR C9BRxtc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaR C4CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaM m4mpdol U c
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
is: CHEBI:37633
is: SBO:0000247

metaM glx m
is: HMDB00119
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:36655
has only substance units: false
initial amount: NaN
name: glyoxylate
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false

metaM dcyt n
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
name: 2'-deoxycytidine
is: CHEBI:15698
is: HMDB00014
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r0915
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
fast: false
reactant: MODEL1310110039#

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6e59e1d1_91d8_448d_91cb_8dab6bf9f7d9
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: B4GALT2
is encoded by: hsa:8704
initial amount: NaN

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR ACACT1rm
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial

metaM sbt D c
constant: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
is: HMDB00247
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17924
name: D-glucitol

metaR FACOAL203
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: true
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM elaidcrn m
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: Elaidic carnitine
is: HMDB06464
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
has only substance units: false
initial amount: NaN

metaM man c
is: SBO:0000247
name: D-Mannose
is: CHEBI:16024
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
boundary condition: false
is: C00159
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaM arg L m
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
is: SBO:0000247
is: HMDB00517
constant: false
is: CHEBI:32682
type: Species
initial amount: NaN
has only substance units: false
name: L-argininium(1+)
initial concentration: 1.0

metaM ksi pre17 g
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
is: CHEBI:28067
type: Species
notes: FORMULA: C157H252N11O127S5X CHARGE: -6

metaR FACOAL204
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
name: fatty-acid--CoA ligase
product: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_d83de889_eb9b_4826_b21a_9e4f163057ec
initial concentration: NaN
is: P48736
is encoded by: hsa:5294
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: PIK3CG
is: SBO:0000252

metaR BILIRED
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.1.24
is described by: ECO:0000000
type: Reaction
reversible: false
name: Nad(p)h biliverdin reductase
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaR PMTCOAtx
name: fatty acid intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM xoltetrol c
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
constant: false
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01231
initial amount: NaN
boundary condition: false
is: CHEBI:17278
initial concentration: 1.0

metaM pail345p hs c
is: SBO:0000247
has only substance units: false
is: CHEBI:57836
type: Species
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
constant: false
initial amount: NaN
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_2f388e5a_a4e8_4aa3_a806_4ba36abf2e0a
initial concentration: NaN
is encoded by: hsa:8140
constant: false
has only substance units: false
is: SBO:0000252
name: SLC7A5
initial amount: NaN
is: Q8IV97
type: Species
boundary condition: true

metaM HC02205 e
name: prostaglandin-b2
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:28099
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b5981d56_d406_4702_85d5_699d9d100bf5
constant: false
boundary condition: true
is: SBO:0000252
name: HK1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098
type: Species
is: B3KXY9
has only substance units: false

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
constant: false
is: CHEBI:57880
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_4e585e08_3f78_40ee_b49f_4e4c3ac75cab
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:23556
name: PIGN
is: SBO:0000252
constant: false
type: Species

metaM sgalside hs g
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00061
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58343
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
name: sulfatide galactocerebroside
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_b57dc78d_673a_4393_9032_3ea38d47748d
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: CH25H
is encoded by: hsa:9023
is: O95992
has only substance units: false

metaM sbt D e
type: Species
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00247
name: D-glucitol

metaR r0913
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM man e
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00169
has only substance units: false
is: C00159
is: SBO:0000247
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
name: D-Mannose
is: CHEBI:16024

metaR RE3241R
name: RE3241
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
reversible: false
product: MODEL1310110039#

metaM oagt3 hs g
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
is: HMDB01514
initial amount: NaN
is: C00329
constant: false
type: Species
boundary condition: false
name: 9-O-Acetylated GT3
is: CHEBI:17315
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_2edce929_c43e_4f09_981e_d58eafe20ba9
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q8NFF2
name: SLC24A4
is encoded by: hsa:123041
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_214e8c50_de0f_4dbd_a24f_bbe8b18e1b50
type: Species
constant: false
boundary condition: true
is encoded by: hsa:215
name: ABCD1
is: P33897
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_368cf6c6_3c06_4f91_918f_e02f3b559cb6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:2180
is: P33121
initial amount: NaN
name: ACSL1

metaM pyr c
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
initial concentration: 1.0
is: CHEBI:15361
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1
boundary condition: false
name: pyruvate
is: C00022
is: HMDB00243

http://identifiers.org/biomodels.db/MODEL1310110039#_d6e00e3e_a50d_4992_b70c_72d987689f0e
name: PIGP
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:51227
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: P57054

metaM glu L m
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:29985
is: SBO:0000247
is: HMDB00148
boundary condition: false

metaM dudp n
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)
has only substance units: false
initial amount: NaN
is: CHEBI:60471
is: SBO:0000247
constant: false
is: HMDB01000
initial concentration: 1.0
boundary condition: false

metaM vacccrn c
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
boundary condition: false
is: HMDB06351
is: SBO:0000247
constant: false
name: Vaccenyl carnitine
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR INSt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110039#
name: Inosine transport (diffusion)
fast: false

metaM xol7ah2 m
boundary condition: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: HMDB06893
is: CHEBI:28047
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_e4111f94_1d36_407a_aeb0_649030f48367
type: Species
name: GCK
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2645
initial concentration: NaN
is: Q53Y25
boundary condition: true

metaR UPPN
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110039#
reversible: false
product: MODEL1310110039#
name: b-ureidopropionase
is: SBO:0000176

metaM arg L e
is: CHEBI:32682
initial amount: NaN
is: SBO:0000247
name: L-argininium(1+)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
is: HMDB00517
type: Species
constant: false

metaM glyc3p x
has only substance units: false
is: CHEBI:57597
is: HMDB00126
is: SBO:0000247
initial concentration: 1.0
is: C00093
name: Glycerol 3-phosphate
boundary condition: false
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
initial amount: NaN

metaM dmnoncrn m
is: HMDB06202
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 4,8 dimethylnonanoyl carnitine
initial amount: NaN

metaM dudp m
type: Species
boundary condition: false
is: HMDB01000
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)
has only substance units: false
initial concentration: 1.0

metaR CYTK5n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
product: MODEL1310110039#
name: cytidylate kinase (CMP),nuclear
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_e1b9447c_6543_4a7d_b35d_6f9e130ed837
has only substance units: false
name: NDUFB10
is encoded by: hsa:4716
initial concentration: NaN
type: Species
is: A8K761
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_6067e2c9_721f_44fd_bdda_fe30b7549740
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4729
constant: false
boundary condition: true
name: NDUFV2
initial amount: NaN
has only substance units: false
is: P19404

metaR HEX10
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
is: SBO:0000176
name: hexokinase (D-glucosamine:ATP)
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction

metaM man g
is: HMDB00169
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
name: D-mannose
type: Species

metaM idour c
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
boundary condition: false
is: HMDB02704
is: SBO:0000247
name: L-iduronate
is: CHEBI:21338
constant: false
initial concentration: 1.0

metaM oagt3 hs e
constant: false
type: Species
name: 9-O-Acetylated GT3
is: CHEBI:18421
has only substance units: false
initial amount: NaN
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
is: SBO:0000247
is: HMDB02168
initial concentration: 1.0
boundary condition: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM odecoa r
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: oleoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57387
type: Species
boundary condition: false
initial amount: NaN

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
is: CHEBI:57312
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial concentration: 1.0
is: SBO:0000247
is: HMDB01356
initial amount: NaN

metaR S6T5g
reactant: MODEL1310110039#
modifier: MODEL1310110039#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000

metaR TTDCAFATPc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR TYMSULT
type: Reaction
is described by: ECO:0000269
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
fast: false
modifier: MODEL1310110039#
name: Tyramine Sulfotransferase
is: SBO:0000176
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.8.2.1

metaM fucgalacglcgalgluside hs g
constant: false
initial concentration: 1.0
has only substance units: false
name: Type IH glycolipid
type: Species
initial amount: NaN
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
is: CHEBI:17158
is: HMDB01167
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_70c8c9b6_5ead_4b40_9308_4e89fefb94c4
initial amount: NaN
boundary condition: true
is encoded by: hsa:158
is: SBO:0000252
constant: false
name: ADSL
has only substance units: false
type: Species
initial concentration: NaN

metaR FACOAL200
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: fatty-acid--CoA ligase
modifier: MODEL1310110039#
is described by: ECO:0000269

metaM 5adtststerone c
initial amount: NaN
is: HMDB02961
boundary condition: false
is: CHEBI:16330
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

http://identifiers.org/biomodels.db/MODEL1310110039#_97b56543_1dc6_4e9c_afad_62d6bb90bbdb
name: FUT1
is encoded by: hsa:2523
is: Q6IZA2
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8b4ac81c_fa0b_410e_9190_296678e30800
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110039#_e005b11d_4bf2_4bac_9675_500393b17245
type: Species
constant: false
is: P56556
name: NDUFA6
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4700

http://identifiers.org/biomodels.db/MODEL1310110039#_d0c574fa_4b57_43d3_aa63_e40497de1ec6
boundary condition: true
is: A8K4A0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ARSB
is encoded by: hsa:411
initial amount: NaN
constant: false
type: Species

metaR r0917
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110039#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_02d952b7_b01d_43e4_8afc_365730106fe3
type: Species
is encoded by: hsa:1119
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P35790
name: CHKA

http://identifiers.org/biomodels.db/MODEL1310110039#_8104a977_8383_4c4e_b2b8_6685e633b755
constant: false
is: SBO:0000252
is encoded by: hsa:285973
initial concentration: NaN
name: ATG9B
has only substance units: false
is: Q674R7
boundary condition: true
initial amount: NaN
type: Species

metaM dgmp m
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: C00362
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
name: dGMP
has only substance units: false
is: CHEBI:57673
is: HMDB01044
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_f20b9153_d90d_47f2_add1_f8e34f813aff
name: PIK3R5
is: SBO:0000252
is encoded by: hsa:23533
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: Q8WYR1
has only substance units: false
boundary condition: true

metaM adrn e
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: adrenic acid
is: SBO:0000247
is: HMDB02226
boundary condition: false
has only substance units: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:53487

http://identifiers.org/biomodels.db/MODEL1310110039#_dc244536_d1e3_479b_816d_128c394f311a
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:728226
constant: false
name: _728226_1_e
boundary condition: true
type: Species

metaM CE1943 e
is: HMDB02329
is: CHEBI:30623
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: spermidine dialdehyde

metaM hs deg4 l
name: heparan sulfate, degradation product 4
is: SBO:0000247
is: HMDB00127
has only substance units: false
initial amount: NaN
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
constant: false
type: Species
boundary condition: false

metaM retinal 11 cis c
boundary condition: false
name: 11-cis-retinal
is: CHEBI:16066
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB02152

metaM dopa c
boundary condition: false
has only substance units: false
name: dopaminium(1+)
is: CHEBI:59905
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species
is: HMDB00073
constant: false
initial concentration: 1.0

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM hpdca c
initial amount: NaN
has only substance units: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: CHEBI:32366
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: margarate
initial concentration: 1.0
is: HMDB02259

http://identifiers.org/biomodels.db/MODEL1310110039#_5aed3057_6d23_4953_94a5_4e1b56001d3b
is: SBO:0000252
constant: false
boundary condition: true
name: PDE1B
has only substance units: false
is: Q7Z364
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:5153

http://identifiers.org/biomodels.db/MODEL1310110039#_7a6994a9_bd83_4379_b642_57502314c91c
initial amount: NaN
boundary condition: true
type: Species
constant: false
name: PLCZ1
is: Q86YW0
initial concentration: NaN
is encoded by: hsa:89869
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ce61b851_6e77_4f15_866a_183d96a7620a
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2806
boundary condition: true
is: P00505
constant: false
name: GOT2
type: Species

metaM sgalside hs l
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00904
name: sulfatide galactocerebroside
is: CHEBI:16349
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR PPItr
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false
name: Diphosphate transporter, endoplasmic reticulum
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110039#

metaM 5adtststerone e
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
has only substance units: false
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
initial amount: NaN
is: CHEBI:16330
is: SBO:0000247
is: HMDB02961
initial concentration: 1.0

metaR r0119
reactant: MODEL1310110039#
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/5.1.3.14
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#
fast: false
reversible: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:

metaR FUM
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction
fast: false
name: fumarase
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110039#
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_28ab3dc2_2354_411c_b9cd_6f6232b24ecf
constant: false
has only substance units: false
is: Q8WXF9
boundary condition: true
is encoded by: hsa:66035
initial concentration: NaN
type: Species
name: SLC2A11
is: SBO:0000252
initial amount: NaN

metaM hexdiac r
initial concentration: 1.0
is: HMDB00672
has only substance units: false
notes: FORMULA: C16H28O4 CHARGE: -2
name: hexadecanediocacid
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: C08260
boundary condition: false

metaM ptdca c
is: SBO:0000247
is: HMDB00826
constant: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: pentadecanoate
is: http://identifiers.org/pubchem.compound/22169126

metaR CORE3GTg
fast: false
modifier: MODEL1310110039#
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR NACHEX15ly
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR r1754
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is described by: ECO:0000000
fast: false
type: Reaction
name: glycerol transport
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_2bcbcb9a_4f92_4023_b2c9_b312fd88bf60
name: DPM2
initial concentration: NaN
constant: false
type: Species
is: O94777
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8818
has only substance units: false

metaM no c
has only substance units: false
is: HMDB03378
is: CHEBI:16480
is: C00533
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: Nitric oxide
type: Species

metaR r0809
type: Reaction
name: Facilitated diffusion
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR SPHS1Pte
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
type: Reaction
name: sphingosine-1-phosphate transport
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is: SBO:0000185

metaM adrn c
is: CHEBI:53487
type: Species
initial concentration: 1.0
name: adrenic acid
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-

metaM citr L m
is: CHEBI:16349
has only substance units: false
name: L-citrulline
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904

metaM gacpail hs r
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:57955
initial amount: NaN
boundary condition: false
type: Species
is: C01236
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01127

metaM vacccrn m
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
has only substance units: false
is: HMDB06351
boundary condition: false
is: SBO:0000247
name: Vaccenyl carnitine
constant: false
type: Species
initial concentration: 1.0

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM HC01459 x
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:27458
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_985742d9_f42e_4e55_8b8b_731b3d656270
is: SBO:0000252
type: Species
is: Q14032
name: BAAT
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:570

metaR GNDer
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#
name: phosphogluconate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
reversible: false

metaM aacoa x
initial amount: NaN
name: acetoacetyl-CoA(4-)
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01484
constant: false
boundary condition: false
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false

metaR PIK3
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol 3-kinase
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.154
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD

metaM prpncoa m
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
boundary condition: false
is: CHEBI:57367
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB02307
name: acryloyl-CoA(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_73700a97_4266_485e_b84d_23987160bda1
name: ADCY3
is: SBO:0000252
type: Species
is encoded by: hsa:109
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: B3KT86

metaR LEUPHELAT2tc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR DITPtn
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#
name: dITP nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false

metaM c3dc e
has only substance units: false
notes: FORMULA: C10H16NO6 CHARGE: -1
constant: false
name: malonyl carnitine
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02095
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_eefd9db5_ec4a_4e25_bd38_a4dade6914ff
is encoded by: hsa:4719
initial amount: NaN
constant: false
type: Species
name: NDUFS1
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P28331
initial concentration: NaN

metaM arg L c
is: CHEBI:32682
has only substance units: false
name: L-argininium(1+)
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaM 2kmb c
constant: false
initial amount: NaN
name: 2-keto-4-methylthiobutyrate
type: Species
is: HMDB01553
has only substance units: false
notes: FORMULA: C5H7O3S CHARGE: -1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16723

http://identifiers.org/biomodels.db/MODEL1310110039#_d384ede6_d971_4592_af74_05685ce64c78
name: GGT1
is: P19440
is encoded by: hsa:2678
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_eb85e405_03d8_4c9d_84d0_e59013345561
has only substance units: false
is: P42765
name: ACAA2
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:10449
initial concentration: NaN
initial amount: NaN
type: Species

metaM sprm c
initial amount: NaN
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
type: Species
constant: false
is: CHEBI:45725
has only substance units: false
is: HMDB01256
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: spermine(4+)

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

metaM triodthy e
constant: false
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
is: SBO:0000247
has only substance units: false
is: HMDB00265
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

metaM xol7ah2 c
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha-diol
is: CHEBI:28047
is: SBO:0000247
initial amount: NaN
is: HMDB06893
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species

metaM glx x
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
is: HMDB00119
has only substance units: false
type: Species
is: CHEBI:36655
initial concentration: 1.0
name: glyoxylate

metaM dolglcp U r
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15812
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
boundary condition: false
is: SBO:0000247

metaR SERGLNexR
is described by: ECO:0000304
kinetic law: MODEL1310110039#
reversible: true
type: Reaction
product: MODEL1310110039#
fast: false
name: L-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaM xol7ah3 m
has only substance units: false
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28540
is: HMDB12455
is: SBO:0000247
boundary condition: false
constant: false

metaM ksi pre15 g
is: SBO:0000247
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 15
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: C00130
type: Species
constant: false
is: CHEBI:58053

metaR SUBEACTD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR URIDK2m
kinetic law: MODEL1310110039#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
name: uridylate kinase (dUMP), mitochondrial
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110039#_ffe07781_c035_420e_954a_4a26ff21276a
initial concentration: NaN
is: P21217
is encoded by: hsa:2525
is: SBO:0000252
type: Species
initial amount: NaN
name: FUT3
constant: false
has only substance units: false
boundary condition: true

metaM uppg3 c
has only substance units: false
constant: false
boundary condition: false
is: C01051
type: Species
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
initial concentration: 1.0
is: SBO:0000247
name: Uroporphyrinogen III
is: CHEBI:57308
is: HMDB01086

http://identifiers.org/biomodels.db/MODEL1310110039#_5c29c124_7415_4a22_b29c_ead16aaa6bb9
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q53Y41
is: SBO:0000252
name: DDC
type: Species
initial concentration: NaN
is encoded by: hsa:1644
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ed56c798_4f30_434f_8f31_5cff41953d69
initial amount: NaN
has only substance units: false
name: EHHADH
constant: false
is: SBO:0000252
is: Q9NY65
type: Species
is encoded by: hsa:1962
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_0da2f10c_db5f_4639_829f_2a6f8c8f7116
constant: false
is encoded by: hsa:4729
name: NDUFV2
is: P19404
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR G5SDym
reversible: false
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
product: MODEL1310110039#
is described by: ECO:0000254
reactant: MODEL1310110039#
fast: false
name: glutamate-5-semialdehyde dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.2.1.41
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaM HC00342 m
constant: false
name: cis-aconitate(3-)
initial concentration: 1.0
is: CHEBI:16383
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaR PYAM5POr
kinetic law: MODEL1310110039#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110039#
name: pyridoxamine 5'-phosphate oxidase
is: SBO:0000176
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
reactant: MODEL1310110039#
type: Reaction
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaM man l
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16024
name: D-mannose
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169

metaR TRDRm
is: SBO:0000176
fast: false
type: Reaction
name: thioredoxin reductase (NADPH)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
modifier: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
reactant: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_0aba3b27_defe_444c_a60c_b1aee800513e
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: DPM2
is encoded by: hsa:8818
is: SBO:0000252
constant: false

metaR A MANASEly
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
reversible: false
kinetic law: MODEL1310110039#
fast: false
name: alpha-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.24
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176

metaR OCCOAtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
name: fatty acid intracellular transport
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true

metaM hpdca e
initial concentration: 1.0
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: HMDB02259
type: Species
constant: false
has only substance units: false
name: margarate
is: SBO:0000247
is: CHEBI:32366
initial amount: NaN
boundary condition: false

metaM sprm e
initial amount: NaN
name: spermine(4+)
boundary condition: false
has only substance units: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
is: HMDB01256
type: Species
constant: false
is: CHEBI:45725
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_386474d4_305f_4f57_b2d7_c36c48949df8
initial amount: NaN
type: Species
initial concentration: NaN
is: P33261
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1557
name: CYP2C19

metaM triodthy c
initial amount: NaN
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:18258

metaR PPItx
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
name: Diphosphate transporter, peroxisome
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6699d810_89dc_450c_a67d_3477401a7d18
name: NDUFA7
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:4701
type: Species
is: SBO:0000252
is: Q6FG42
initial concentration: NaN

metaM pail hs n
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
type: Species
is: CHEBI:57880
is: SBO:0000247
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaM 7dhchsterol c
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17759
is: HMDB00032

metaR G6Pter
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaM ptdca e
name: pentadecanoate
has only substance units: false
is: HMDB00826
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/22169126
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_22f7cfa6_d107_459c_9db2_eceebdd1e8d4
name: RPIA
constant: false
boundary condition: true
is encoded by: hsa:22934
has only substance units: false
is: P49247
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaR G14T6g
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110039#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR RE1804M
product: MODEL1310110039#
reactant: MODEL1310110039#
name: RE1804
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
modifier: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_4df1d3c4_ffe3_45e2_a41b_34b823fa122a
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: OCRL
is encoded by: hsa:4952
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR NAGLCAly
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
name: N-acetylglucosaminidase, lysosomal

metaR CLPNDCOAtx
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185

metaR r0113
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
fast: false

metaM dmnoncrn x
constant: false
boundary condition: false
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06202
type: Species
initial concentration: 1.0

metaM dolp L c
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57683
has only substance units: false
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR EX 3deccrn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_db94ce8d_b28f_404b_b120_4957738c44ea
boundary condition: true
has only substance units: false
is: Q9NY65
name: EHHADH
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:1962
constant: false
initial amount: NaN

metaM idour l
is: HMDB02704
name: L-iduronate
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:21338
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN

metaM ksi deg31 l
is: CHEBI:57455
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
name: keratan sulfate I, degradation product 31
has only substance units: false
is: HMDB01354
type: Species

metaM ksii core2 deg3 l
is: HMDB00143
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
constant: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false

metaM srtn e
name: serotonin(1+)
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00259
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
is: CHEBI:350546
type: Species

metaM c8dc x
constant: false
initial amount: NaN
is: HMDB00893
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1

metaR C140CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM ttdca c
name: myristate
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
constant: false
has only substance units: false
is: HMDB00806
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_bd100a1f_d9fe_4bb8_a874_839bed774e0d
constant: false
is encoded by: hsa:5150
name: PDE7A
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR DURAD2
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
type: Reaction
name: dihydrothymin dehydrogenase (NADP)
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

http://identifiers.org/biomodels.db/MODEL1310110039#_2b83dc6b_9d88_4043_8eb7_c785dea57e3e
boundary condition: true
is: Q15147
is: SBO:0000252
has only substance units: false
name: PLCB4
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5332
constant: false

metaR 5ADTSTSTERONEtr
type: Reaction
fast: false
reactant: MODEL1310110039#
name: 5 alpha dihydrotesterone intracellular transport
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM mal L c
initial amount: NaN
is: SBO:0000247
name: (S)-malate(2-)
initial concentration: 1.0
constant: false
is: CHEBI:15589
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
has only substance units: false
is: HMDB00156

metaR OAGT3te
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
product: MODEL1310110039#
name: oagt3 hs transport
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110039#

metaR RAI2
type: Reaction
name: retinal isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110039#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_5bc0822e_3268_4745_80e7_938b8c9f2c3d
initial amount: NaN
name: PTS
is: Q03393
has only substance units: false
boundary condition: true
is encoded by: hsa:5805
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM 3hexdtetcoa m
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: HMDB02288
boundary condition: false

metaM dhap c
is: CHEBI:57642
is: C00111
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
is: HMDB01473

metaR r0074
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000

metaR PROSTGD2t
name: prostaglandin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
type: Reaction
modifier: MODEL1310110039#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#

metaM gam c
type: Species
is: HMDB01514
is: C00329
has only substance units: false
boundary condition: false
name: D-Glucosamine
is: CHEBI:17315
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329

http://identifiers.org/biomodels.db/MODEL1310110039#_416db7f8_9185_4d52_b106_f61fb66c67cd
boundary condition: true
initial concentration: NaN
name: ACSS1
has only substance units: false
is: Q9NUB1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:84532
constant: false
type: Species

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_dc017fd6_f685_4538_aae6_267444a20184
constant: false
type: Species
initial amount: NaN
is: Q16836
is encoded by: hsa:3033
name: HADH
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM pd3 c
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: Previtamin D3
is: HMDB06500
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial concentration: 1.0

metaR HSAT2ly
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_37a68c90_fef2_44a6_a119_71fb5cb97e92
initial amount: NaN
name: DTYMK
is encoded by: hsa:1841
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P23919

metaM HC01842 c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:31997
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
constant: false

metaM o2s x
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
name: superoxide
type: Species
constant: false
is: HMDB02168
is: SBO:0000247
is: CHEBI:18421
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM dodecanac x
is: SBO:0000247
name: Dodecanedioic acid
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00623
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H20O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110039#_204f0afd_94b2_40b8_acd3_d75095a46609
type: Species
boundary condition: true
is encoded by: hsa:219
initial concentration: NaN
is: SBO:0000252
constant: false
is: P30837
initial amount: NaN
has only substance units: false
name: ALDH1B1

metaR r0783
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
modifier: MODEL1310110039#
fast: false
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_f6054463_d5af_46a8_8ae1_0b9b04d929dd
initial amount: NaN
constant: false
name: PYCR2
has only substance units: false
is encoded by: hsa:29920
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q96C36
type: Species

metaR r1418
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is: SBO:0000176

metaR ACETONEt2m
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110039#
is: SBO:0000185
name: acetone mitochondrial transport via proton symport
fast: false
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#

metaR LCADi
modifier: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
kinetic law: MODEL1310110039#
is: SBO:0000176
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reactant: MODEL1310110039#

metaM udpacgal g
is: CHEBI:57847
initial amount: NaN
type: Species
is: HMDB00304
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_c6d41f6e_e557_47dc_994b_720a2ec760a7
boundary condition: true
initial concentration: NaN
type: Species
is: P49753
initial amount: NaN
is: SBO:0000252
name: ACOT2
has only substance units: false
is encoded by: hsa:10965
constant: false

metaM mal L e
initial concentration: 1.0
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
name: (S)-malate(2-)
is: CHEBI:15589
boundary condition: false
type: Species
is: HMDB00156
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR OAGT3tg
is described by: ECO:0000000
name: oagt3 hs intracellular transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#

metaR r0784
fast: false
product: MODEL1310110039#
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_d9813294_0334_4121_8b16_eb8247fa9707
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: GPD1
is encoded by: hsa:2819
is: F8W1L5
is: SBO:0000252

metaR DTDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: true
product: MODEL1310110039#
name: dTDP nuclear transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR FAOXC225C226x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_ff9a35d1_9bfb_4b9b_9e4d_1dc68b107ed8
initial amount: NaN
is encoded by: hsa:5295
boundary condition: true
has part: B4DER4
is encoded by: hsa:5291
type: Species
initial concentration: NaN
name: PIK3CB:PIK3R1
constant: false
has only substance units: false
has part: B3KT19
is: SBO:0000297

metaM HC00361 c
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: SBO:0000247
is: CHEBI:58335
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: sedoheptulose 1,7-bisphosphate(4-)
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_3e2c6079_4ee3_4a38_9b73_0ba765017c4b
is encoded by: hsa:100128062
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _100128062_1_m
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_9fda2c02_8e2e_4109_972a_1818e0ac5b06
has part: P56381
has part: A8K092
is encoded by: hsa:514
is encoded by: hsa:513
has part: P36542
is: SBO:0000297
boundary condition: true
is encoded by: hsa:509
is encoded by: hsa:498
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial amount: NaN
has part: P30049
type: Species
initial concentration: NaN
has part: P06576
constant: false
is encoded by: hsa:506
has only substance units: false

metaM leu L c
has only substance units: false
is: SBO:0000247
is: HMDB00687
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
initial concentration: 1.0
name: L-leucine
constant: false
type: Species
boundary condition: false

metaR FAOXC81C61m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_e0881ce2_f09a_400a_9456_17130e907c7e
has part: Q6FGA0
has part: Q6YFQ2
has part: H0UI06
is: SBO:0000297
is encoded by: hsa:1350
boundary condition: true
is encoded by: hsa:1347
is encoded by: hsa:1345
has part: P12074
has part: P00414
initial concentration: NaN
is encoded by: hsa:4514
is encoded by: hsa:4512
has part: Q53XN1
is encoded by: hsa:1329
is encoded by: hsa:341947
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q7GXZ8
is encoded by: hsa:1351
has only substance units: false
constant: false
type: Species
is encoded by: hsa:9167
has part: P24311
is encoded by: hsa:1346
is encoded by: hsa:1327
has part: P15954
has part: Q53YB7
is encoded by: hsa:1339
is encoded by: hsa:1337
has part: Q7Z4L0
is encoded by: hsa:1340
initial amount: NaN
is encoded by: hsa:84701
is encoded by: hsa:125965
has part: P09669
has part: Q02221
is encoded by: hsa:1349
has part: Q96KJ9
is encoded by: hsa:9377
has part: P14854
is encoded by: hsa:4513
has part: Q7GXY8
has part: P20674
has part: Q8TF08
has part: P24310
is encoded by: hsa:170712
has part: P13073

metaR FAOXC184C163x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_2ca6cab7_5b07_45b6_97af_b67b6e9e57e2
type: Species
name: HK1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3098
constant: false
has only substance units: false
initial amount: NaN
is: P78542

metaM zym int2 r
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
has only substance units: false
is: CHEBI:52386
constant: false
name: zymosterol intermediate 2
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR B3GALT3g
modifier: MODEL1310110039#
fast: false
name: Beta-1,3-galactosyltransferase 3
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79
product: MODEL1310110039#
reversible: false

metaR r0781
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM no e
initial amount: NaN
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
type: Species
constant: false
is: SBO:0000247
is: C00533
is: CHEBI:16480
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB03378

metaM tyr L c
is: HMDB00158
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
initial concentration: 1.0
name: L-tyrosine
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b3f2b843_f516_4eb5_94a0_7f0a86b10084
is: Q6P1K9
constant: false
has only substance units: false
is encoded by: hsa:80025
type: Species
name: PANK2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR DOPAt4 2 r
name: Dopamine reversible transport in via sodium symport (1:2)
is: SBO:0000185
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is described by: ECO:0000269
product: MODEL1310110039#
type: Reaction
reversible: true
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_6e6b3182_0f8e_4054_82f8_b0ea35ff6fe9
is: P45954
is encoded by: hsa:36
type: Species
has only substance units: false
initial amount: NaN
name: ACADSB
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR F1Atg
reversible: true
reactant: MODEL1310110039#
type: Reaction
name: F1alpha transport (from golgi to lysosome)
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000

metaR PAIL45P HStn
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaM xol7ah3 c
initial concentration: 1.0
is: CHEBI:28540
boundary condition: false
has only substance units: false
is: HMDB12455
constant: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444

metaR RE3628M
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
type: Reaction
name: RE3628
reactant: MODEL1310110039#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_93989901_73e6_495d_9494_a857d4f3905c
initial concentration: NaN
constant: false
name: LIPC
is: SBO:0000252
type: Species
is encoded by: hsa:3990
initial amount: NaN
is: A6H8L5
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_0cf6fab3_7ab1_4d8d_8cbe_f6ec6b5fe357
constant: false
is: SBO:0000252
is encoded by: hsa:6901
type: Species
name: TAZ
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q16635
initial concentration: NaN

metaR r0821
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110039#
is: SBO:0000185
modifier: MODEL1310110039#

metaM adpac c
constant: false
boundary condition: false
type: Species
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00448
name: adipic acid

metaM sphs1p e
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
initial amount: NaN
is: HMDB00277
boundary condition: false
type: Species
name: sphingosine 1-phosphate(1-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:60119

http://identifiers.org/biomodels.db/MODEL1310110039#_94229ae2_471d_4c67_b307_3f43541991e8
type: Species
initial concentration: NaN
name: ALDOA
has only substance units: false
is: P04075
initial amount: NaN
is encoded by: hsa:226
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_a58daab0_281c_4e26_8204_79a4aac856a4
name: UCK2
boundary condition: true
is encoded by: hsa:7371
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q9BZX2

http://identifiers.org/biomodels.db/MODEL1310110039#_96d1f89e_3db6_4691_937a_cf9923c6b7eb
initial concentration: NaN
type: Species
is encoded by: hsa:1636
has only substance units: false
is: B4DKH4
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: ACE

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
modifier: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110039#
name: sialidase, lysosomal
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110039#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false

metaR r0822
reversible: true
product: MODEL1310110039#
modifier: MODEL1310110039#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110039#

metaM msa m
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
initial concentration: 1.0
is: SBO:0000247
name: 3-oxopropanoate
initial amount: NaN
constant: false
is: HMDB11111
is: CHEBI:33190
has only substance units: false
boundary condition: false
type: Species

metaM ac e
is: SBO:0000247
initial amount: NaN
is: CHEBI:30089
boundary condition: false
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00042
type: Species

metaM lpchol hs e
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial amount: NaN
is: CHEBI:60479
constant: false
initial concentration: 1.0
name: lysophosphatidylcholine
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

metaM srtn c
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:350546
has only substance units: false
name: serotonin(1+)
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00259

http://identifiers.org/biomodels.db/MODEL1310110039#_190332f7_198b_4fd7_a53a_f65498d91e71
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:196883
boundary condition: true
type: Species
is: Q8NFM4
name: ADCY4
initial concentration: NaN
constant: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR EX 3ivcrn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_73d6f048_4822_450e_bffc_4c3f27c36d9f
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PLCG2
constant: false
is: SBO:0000252
is encoded by: hsa:5336
is: P16885
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e617a6c2_d728_4df0_85d1_bd622f11e860
initial concentration: NaN
is: B1AK53
is: SBO:0000252
type: Species
name: ESPN
constant: false
initial amount: NaN
is encoded by: hsa:83715
boundary condition: true
has only substance units: false

metaM ddeccrn e
is: SBO:0000247
type: Species
name: lauroyl carnitine
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02250
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110039#_7c535352_7c28_433f_b87a_a29707433965
is: P16219
is: SBO:0000252
initial concentration: NaN
name: ACADS
type: Species
boundary condition: true
is encoded by: hsa:35
has only substance units: false
constant: false
initial amount: NaN

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR 2HCO3 NAt
fast: false
product: MODEL1310110039#
reversible: true
is described by: ECO:0000269
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#

metaM g3m8mpdol U r
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: C05873
type: Species
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_5856a12c_39aa_44da_8e43_79c9aa3c7315
is: B4DK61
constant: false
is encoded by: hsa:51
name: ACOX1
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM dhap e
type: Species
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: glycerone phosphate(2-)
initial amount: NaN
is: SBO:0000247
is: HMDB01473
is: CHEBI:57642

metaM gam e
constant: false
is: C00329
is: CHEBI:17315
name: D-Glucosamine
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: HMDB01514
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1123bbf1_5b75_46bc_ac51_c1e60cc9c7d4
is: Q6P1K9
boundary condition: true
initial amount: NaN
name: PANK2
initial concentration: NaN
is encoded by: hsa:80025
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR r0780
reversible: true
reactant: MODEL1310110039#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110039#
is: SBO:0000176

metaR FUMSO3tm
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
fast: false
reversible: true
type: Reaction
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_0f43ae77_3214_4a00_b195_db9a3e193fec
has part: E7EX19
is encoded by: hsa:5295
constant: false
initial amount: NaN
name: PIK3CD:PIK3R1
initial concentration: NaN
is: SBO:0000297
type: Species
has only substance units: false
boundary condition: true

metaR FAOXC102C101m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_5c036496_f465_4d82_8272_0c1431b2baa5
constant: false
is: Q16850
type: Species
name: CYP51A1
is encoded by: hsa:1595
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_90c3be05_a3eb_45e6_b290_bf1d0d1f9469
initial concentration: NaN
is: P52789
initial amount: NaN
is: SBO:0000252
name: HK2
boundary condition: true
constant: false
is encoded by: hsa:3099
has only substance units: false
type: Species

metaM 3octdece1coa m
name: 3-hydroxyoctadecenoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
constant: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_76dd72d4_715e_493c_aa15_4c7b8bdc58e9
is encoded by: hsa:2530
is: Q9BYC5
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: FUT8
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM udpacgal l
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57847
has only substance units: false
is: HMDB00304
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false

metaR PPItm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
product: MODEL1310110039#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110039#
name: diphopshate transporter, mitochondrial
fast: false

metaM cala c
is: SBO:0000247
constant: false
name: N-carbamoyl-beta-alaninate
initial amount: NaN
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00026
type: Species
is: CHEBI:11892

metaR DTTPtn
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: dTTP diffusion in nucleus
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000

metaM HC02216 c
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
constant: false
is: CHEBI:28922
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_e60fffe4_153a_4edc_945c_c8b371407c38
name: SULT1A2
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6799
has only substance units: false
constant: false

metaR UMPKn
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110039#
name: UMP kinase, nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

metaM ddeccrn c
name: lauroyl carnitine
boundary condition: false
is: HMDB02250
constant: false
notes: FORMULA: C19H37NO4 CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_700a8db1_5f8a_46d4_9952_52b54321acf4
type: Species
initial concentration: NaN
is encoded by: hsa:1892
has only substance units: false
name: ECHS1
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P30084

metaM o2s n
boundary condition: false
is: SBO:0000247
is: HMDB02168
name: superoxide
type: Species
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_2ca134ce_be5d_4d4a_8249_719dfba97d61
initial amount: NaN
type: Species
is encoded by: hsa:AI620219
boundary condition: true
name: _AI620219_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_0334e849_d29c_4823_9f03_a46cd30981f8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23464
boundary condition: true
name: GCAT
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: E2QC23

http://identifiers.org/biomodels.db/MODEL1310110039#_849e5a4d_50ed_4bf7_8015_43e995b98a37
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10195
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ALG3

metaM lpchol hs c
constant: false
initial concentration: 1.0
is: CHEBI:60479
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
name: lysophosphatidylcholine

metaR RE2426C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
fast: false
reversible: true
product: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: RE2426
type: Reaction

metaM hexdiac c
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: C08260
is: HMDB00672
has only substance units: false
name: hexadecanediocacid
constant: false
initial concentration: 1.0
notes: FORMULA: C16H28O4 CHARGE: -2

metaR PFK26
is version of: http://identifiers.org/ec-code/2.7.1.105
fast: false
name: 6-phosphofructo-2-kinase
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF

metaR r0672
is: SBO:0000176
modifier: MODEL1310110039#
fast: false
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
product: MODEL1310110039#
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is described by: ECO:0000000

metaR ACCOAtn
name: acetyl-CoA transport, nuclear
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

metaR C6CRNtcx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaR C12DCACOT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaM o2s m
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: C00704
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:18421
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02168
has only substance units: false
name: Superoxide anion

http://identifiers.org/biomodels.db/MODEL1310110039#_c43cf8d7_1dce_4f7a_8cff_4efacc51192e
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: NADSYN1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55191
is: Q6IA69
is: SBO:0000252

metaR M1316Mg
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.114
is: SBO:0000176
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
type: Reaction
product: MODEL1310110039#
fast: false

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR FAOXC10C10OHm
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM bhb c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: (R)-3-hydroxybutyrate
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
has only substance units: false
is: HMDB00011

metaR ANDRSTRNtr
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110039#
name: androsterone intracellular transport
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_deb10d75_dc79_4eab_988f_ff9222be370f
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q13057
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:80347
name: COASY

http://identifiers.org/biomodels.db/MODEL1310110039#_f9758e41_ccb7_48b1_a2b8_f4f91c8824f6
is encoded by: hsa:570
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is: Q14032
initial concentration: NaN
name: BAAT
type: Species
has only substance units: false

metaM tyr L e
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17895
constant: false
name: L-tyrosine
is: HMDB00158
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

http://identifiers.org/biomodels.db/MODEL1310110039#_9365c195_5d72_46fd_ac19_43169849cbc5
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P55084
is encoded by: hsa:3032
name: HADHB
boundary condition: true

metaR ALACYSNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
product: MODEL1310110039#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
type: Reaction
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)

metaR r0670
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reactant: MODEL1310110039#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
type: Reaction
is described by: ECO:0000000

metaM leu L m
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: CHEBI:15603
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00687
name: L-leucine
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR r0931
product: MODEL1310110039#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110039#

metaM tdcrn c
boundary condition: false
notes: FORMULA: C21H41NO4 CHARGE: 0
constant: false
name: myristoyl carnitine
initial concentration: 1.0
type: Species
is: HMDB05066
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_2a273b40_2136_402f_b74a_ecff9b14f793
has only substance units: false
is encoded by: hsa:211
is: Q5JAM2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ALAS1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_ba055d95_ea3b_4025_ab16_cba92c505c88
name: CA12
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:771
is: SBO:0000252
is: O43570

metaR 3HKYNAKGAT
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is described by: ECO:0000304
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.7

metaM CE1940 e
name: spermidine monoaldehyde 2
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
constant: false
initial amount: NaN
is: HMDB02329
is: CHEBI:30623
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_fd914ca5_57c3_4440_9857_ccd12c3a5116
name: ME3
initial amount: NaN
boundary condition: true
is encoded by: hsa:10873
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q6TCH8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_76baae76_f1fe_46b7_9214_9eb47e2344ae
boundary condition: true
initial concentration: NaN
is: Q38G75
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:2582
has only substance units: false
name: GALE

http://identifiers.org/biomodels.db/MODEL1310110039#_d6507fbf_93b8_46be_a71c_58b23bb3ea24
type: Species
is encoded by: hsa:275
initial concentration: NaN
has only substance units: false
name: AMT
is: SBO:0000252
boundary condition: true
is: P48728
constant: false
initial amount: NaN

metaM sphs1p c
constant: false
initial amount: NaN
is: HMDB00277
is: CHEBI:60119
type: Species
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: sphingosine 1-phosphate(1-)

metaM bhb e
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:10983
is: HMDB00011
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaR r0932
reversible: true
kinetic law: MODEL1310110039#
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#

metaR CGLYt3 2
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000304
name: Cys-Gly transport in via proton symport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_c17ef405_533a_4841_8e74_a972b343886b
boundary condition: true
is: Q9H845
is: SBO:0000252
has only substance units: false
type: Species
name: ACAD9
is encoded by: hsa:28976
constant: false
initial concentration: NaN
initial amount: NaN

metaM sgalside hs c
type: Species
is: HMDB03406
is: CHEBI:16523
has only substance units: false
constant: false
name: sulfatide galactocerebroside
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_2a8c674c_b21f_4b43_ac10_a84495a68660
has only substance units: false
boundary condition: true
name: GALT
is: SBO:0000252
initial concentration: NaN
type: Species
is: B4E097
constant: false
is encoded by: hsa:2592
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_8c2a4dff_4978_4875_9130_6381e4b5a244
type: Species
is: O43175
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26227
constant: false
initial amount: NaN
name: PHGDH
has only substance units: false

metaM dudp c
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C01346
is: CHEBI:60471
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01000
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP

metaM tdcrn e
notes: FORMULA: C21H41NO4 CHARGE: 0
has only substance units: false
name: myristoyl carnitine
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB05066
boundary condition: false

metaR ACCOAtr
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
name: acetyl-coa transport
type: Reaction
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD

metaM cpppg3 c
initial amount: NaN
has only substance units: false
is: HMDB01261
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
type: Species
is: C03263
is: CHEBI:57309
name: Coproporphyrinogen III

metaM gthox c
is: CHEBI:58297
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: Oxidized glutathione
is: C00127
boundary condition: false
is: HMDB03337
initial amount: NaN

metaM leu L e
is: HMDB00687
type: Species
name: L-leucine
has only substance units: false
initial amount: NaN
is: CHEBI:15603
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_14e012f2_57d4_4a27_94d0_6cb11ea93b9a
boundary condition: true
is encoded by: hsa:BE966236
name: _BE966236_1_m
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_8f4de95a_e6e8_4dcb_a6ac_46fdb0048296
name: SLC1A4
initial amount: NaN
type: Species
initial concentration: NaN
is: P43007
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:6509

metaR RETH1
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase (9-cis)
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_66eaee39_cbb9_4592_967e_e5a649db9730
name: ALAD
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: Q6ZMU0
boundary condition: true
is encoded by: hsa:210

metaM peamn c
boundary condition: false
is: CHEBI:225237
name: 2-phenylethanaminium
initial amount: NaN
is: HMDB12275
has only substance units: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_45bfae52_7085_4934_af43_5df23d5d38e0
is encoded by: hsa:5476
is: SBO:0000252
name: CTSA
initial concentration: NaN
boundary condition: true
constant: false
is: P10619
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_a4b13886_1946_47ce_8098_d2c3b4cda869
boundary condition: true
type: Species
name: RPN1
initial amount: NaN
initial concentration: NaN
constant: false
is: P04843
has only substance units: false
is encoded by: hsa:6184
is: SBO:0000252

metaM dolglcp U c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
is: CHEBI:15812
constant: false

metaM ksi deg7 l
boundary condition: false
initial amount: NaN
name: keratan sulfate I, degradation product 7
type: Species
is: HMDB01354
is: SBO:0000247
has only substance units: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
is: CHEBI:57455
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_9d35b099_a3b3_4015_8bbf_131e7150d1db
boundary condition: true
is encoded by: hsa:514
is: SBO:0000252
initial amount: NaN
name: ATP5E
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: P56381

metaM doco13ecoa x
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
boundary condition: false
name: 13-docosenoylcoa
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
initial amount: NaN

metaM HC02205 c
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: CHEBI:28099
constant: false
name: prostaglandin-b2
initial concentration: 1.0
type: Species

metaM tetdece1coa c
type: Species
boundary condition: false
is: HMDB05066
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: tetradecenoylcoa
notes: FORMULA: C35H56N7O17P3S CHARGE: -4

metaR CHSTEROLtrc
reactant: MODEL1310110039#
is: SBO:0000185
name: transport of cholesterol into the cytosol
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
product: MODEL1310110039#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110039#_978927d7_91f7_4d9d_b3a1_91d9032d2833
initial amount: NaN
constant: false
name: _AI697028_1_e
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI697028
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_6b676928_6bcd_46e7_96f6_9ae0932b6024
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O14495
constant: false
initial amount: NaN
name: PPAP2B
has only substance units: false
is encoded by: hsa:8613
type: Species

metaM cs b l
is: CHEBI:36005
is: HMDB02183
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR CO2ter
is described by: ECO:0000000
name: CO2 endoplasmic reticular transport via diffusion
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true

metaR RE3520E
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
product: MODEL1310110039#
name: RE3520
is version of: http://identifiers.org/ec-code/1.11.1.9

http://identifiers.org/biomodels.db/MODEL1310110039#_aaa623fb_322d_4d45_a925_dc5aa134b172
has only substance units: false
is: P28331
initial concentration: NaN
is encoded by: hsa:4719
name: NDUFS1
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR PROSTGH2t
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
name: Prostaglandin H2 transport
reversible: true
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaM ac m
name: acetate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00042
constant: false
type: Species
is: CHEBI:30089
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN

metaM CE5788 e
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: CHEBI:27485
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB02710
name: kinetensin 1-7

http://identifiers.org/biomodels.db/MODEL1310110039#_d5679986_1ce4_4217_ba24_b21fb7955515
constant: false
is encoded by: hsa:4697
initial concentration: NaN
name: NDUFA4
has only substance units: false
initial amount: NaN
is: O00483
boundary condition: true
type: Species
is: SBO:0000252

metaM HC01401 x
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0c4f94e7_cc3a_4fac_91c0_849d85444e45
is encoded by: hsa:5288
boundary condition: true
is: O75747
name: PIK3C2G
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_954b05d8_c457_48dd_964d_827f82a999ad
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: SGPP2
is: Q8IWX5
type: Species
is encoded by: hsa:130367
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_25d485c3_a07b_4ba1_afaa_eccf202efaa3
name: NDUFS5
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: Q6IBA0
constant: false
is encoded by: hsa:4725
is: SBO:0000252

metaM tchola x
name: taurocholate
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: CHEBI:36257
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00036
initial amount: NaN
boundary condition: false
constant: false

metaR DM gpi sig er
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_851099bb_e75c_4140_9ab8_316392bf39b8
name: HSD3B2
has only substance units: false
boundary condition: true
is encoded by: hsa:3284
initial concentration: NaN
is: SBO:0000252
is: P26439
type: Species
constant: false
initial amount: NaN

metaM acgam c
is: SBO:0000247
is: HMDB00215
is: CHEBI:17411
name: N-acetyl-D-glucosamine
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

metaM cyan m
initial concentration: 1.0
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
has only substance units: false
is: HMDB02084
is: CHEBI:18407
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaM ksi pre30 g
is: C00130
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
is: CHEBI:58053
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 30
is: SBO:0000247
type: Species
constant: false

metaM ddece1crn c
type: Species
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
is: HMDB03712
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: dodecenoyl carnitine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1b1a9145_793f_47b3_a5c3_719c74b9db10
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: Q8N3T1
name: GALNTL2
is encoded by: hsa:117248
type: Species
boundary condition: true
has only substance units: false

metaM leuktrB4 c
boundary condition: false
is: CHEBI:57461
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
name: leukotriene B4(1-)
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110039#_4b8961dc_4a03_4964_a865_b4fbddd57eda
initial concentration: NaN
is: O00462
type: Species
is encoded by: hsa:4126
boundary condition: true
name: MANBA
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR FAOXC164C165x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR PPAm
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110039#
is: SBO:0000176
reversible: false
modifier: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110039#
name: inorganic diphosphatase

metaR FAOXC102C101x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR r1304
reactant: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
type: Reaction
name: Vesicular transport
product: MODEL1310110039#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_e36ac11a_162d_4dc9_9572_4ccbade84616
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:197257
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: LDHD

metaR FAOXC184C163m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR r0926
product: MODEL1310110039#
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:

metaM o2s e
is: HMDB02168
is: SBO:0000247
has only substance units: false
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:18421
initial amount: NaN

metaM accoa c
initial amount: NaN
constant: false
is: HMDB01206
boundary condition: false
name: Acetyl-CoA
is: C00024
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: CHEBI:57288
is: SBO:0000247
initial concentration: 1.0

metaM HC02213 c
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:28031
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
constant: false
name: prostaglandin-e3

http://identifiers.org/biomodels.db/MODEL1310110039#_cf6c1085_77c0_46fd_abce_8faa88b0ca4d
boundary condition: true
is: SBO:0000252
name: AICDA
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: Q546Y9
is encoded by: hsa:57379

metaM cholcoar r
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false
is: CHEBI:58677
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02178
is: SBO:0000247
initial concentration: 1.0
type: Species
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaM co e
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01361
name: carbon monoxide
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: CHEBI:17245
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR FAOXC8C6m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaM HC02210 e
initial amount: NaN
boundary condition: false
name: prostaglandin-d3
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: CHEBI:34939
constant: false

metaR HSD17B42x
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110039#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
type: Reaction
modifier: MODEL1310110039#
name: hydroxysteroid (17-beta) dehydrogenase 4

http://identifiers.org/biomodels.db/MODEL1310110039#_f2d17b19_0854_4e11_af68_536bdb556f39
boundary condition: true
is encoded by: hsa:23236
constant: false
is: Q9NQ66
name: PLCB1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_bbaf2186_826d_49e4_9e53_502552993a28
initial amount: NaN
is: P51688
constant: false
is: SBO:0000252
is encoded by: hsa:6448
has only substance units: false
name: SGSH
initial concentration: NaN
boundary condition: true
type: Species

metaM gmp g
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
initial concentration: 1.0
is: HMDB01397
has only substance units: false
is: SBO:0000247
is: CHEBI:58115
name: GMP(3-)
boundary condition: false

metaM man6p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: CHEBI:17369
initial concentration: 1.0
has only substance units: false
is: HMDB01078
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: D-Mannose 6-phosphate
constant: false

metaR r1303
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
reversible: false

metaR HSD17B4x
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
name: hydroxysteroid (17-beta) dehydrogenase 4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false

metaM tetpent6 c
type: Species
boundary condition: false
constant: false
name: tetracosapentaenoic acid, n-6
is: SBO:0000247
is: HMDB06322
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN

metaM 3hdcoa m
initial concentration: 1.0
name: (S)-3-Hydroxydecanoyl-CoA
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_7645afeb_b809_4c05_8dfd_88b88e913a70
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3939
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P00338
name: LDHA
constant: false
type: Species

metaR S6TASE8ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reversible: true
is: SBO:0000176
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR DOLMANP Uter
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
name: dolichol-phosphate mannose flippase (uterus)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction

metaR AICART
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176

metaM leuktrB4 e
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
initial amount: NaN
name: leukotriene B4(1-)
initial concentration: 1.0
is: HMDB01085
is: CHEBI:57461

metaM malttr e
is: CHEBI:27931
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
type: Species
initial amount: NaN
name: maltotriose
is: C01835
is: SBO:0000247
constant: false
is: HMDB01262
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM ddece1crn e
initial amount: NaN
type: Species
notes: FORMULA: C19H35NO4 CHARGE: 0
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB02250
name: dodecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110039#_4d0f9338_e06a_4a0b_94c8_2ce7e8d77d6f
name: SLC25A2
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:83884
constant: false
is: Q9BXI2
initial concentration: NaN
is: SBO:0000252

metaM ksi deg30 l
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
boundary condition: false
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate I, degradation product 30
constant: false

metaR r0679
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false
modifier: MODEL1310110039#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_c91d0e1b_051a_4d11_990f_69f0971c65ea
constant: false
initial amount: NaN
is encoded by: hsa:257068
boundary condition: true
is: Q0VAA5
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: PLCXD2

metaM HC02213 e
name: prostaglandin-e3
constant: false
initial amount: NaN
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM oaa m
constant: false
is: HMDB00223
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00036
is: CHEBI:16452
type: Species
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
name: Oxaloacetate

metaM gmp c
is: SBO:0000247
is: HMDB01397
type: Species
initial concentration: 1.0
is: CHEBI:58115
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: C00144
constant: false
name: GMP

http://identifiers.org/biomodels.db/MODEL1310110039#_702f9059_01db_4ba0_bdce_49951403d012
initial concentration: NaN
is: P07741
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: APRT
boundary condition: true
type: Species
is encoded by: hsa:353

http://identifiers.org/biomodels.db/MODEL1310110039#_511f339c_eb69_4e69_9488_b708bc968153
name: HMGCL
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3155
is: Q6IBC0

metaM HC02210 c
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:34939

http://identifiers.org/biomodels.db/MODEL1310110039#_7376e65f_8296_49e1_8a20_2f1f2b0e9c10
initial amount: NaN
is: Q53H96
name: PYCRL
has only substance units: false
type: Species
is encoded by: hsa:65263
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM ksii core4 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
notes: FORMULA: C36H60N3O25X CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:28067
is: SBO:0000247

metaM tetpent6 e
name: tetracosapentaenoic acid, n-6
has only substance units: false
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB06322
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_b2a0a19e_2a64_4f4f_abbe_7d3aebac2edc
name: SLC40A1
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NP59
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:30061
initial concentration: NaN

metaR VACCt
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110039#_0f5bab22_0f73_4795_8e9a_dd87c235b821
is: SBO:0000252
type: Species
has only substance units: false
is: Q4W5N8
initial concentration: NaN
constant: false
name: AADAT
boundary condition: true
is encoded by: hsa:51166
initial amount: NaN

metaR AKR1D2
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
modifier: MODEL1310110039#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.1.3
fast: false
is described by: ECO:0000269
reactant: MODEL1310110039#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

metaM 2hexdtetcoa x
boundary condition: false
name: 2,7,10,13-hexadecatetraenoylcoa
has only substance units: false
initial concentration: 1.0
is: HMDB02288
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247

metaM CE4872 c
boundary condition: false
is: CHEBI:15748
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00127
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_a3e4af50_a7f1_4a21_b317_f1e48b98461b
name: MYO5B
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: Q9H6Y6
constant: false
is encoded by: hsa:4645
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_1a35db09_01a6_46b7_9811_dc04cccacd3e
constant: false
initial concentration: NaN
is: SBO:0000252
name: COX6C
type: Species
is encoded by: hsa:1345
has only substance units: false
is: P09669
initial amount: NaN
boundary condition: true

metaR RE3242R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
name: RE3242
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110039#

metaR THRGLYexR
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: L-threonine/glycine reversible exchange
fast: false
is described by: ECO:0000304
is: SBO:0000185

metaM accoa g
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: CHEBI:57288
type: Species
name: acetyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110039#_63b5c302_2298_4394_b398_f18709eed800
is: P48775
is encoded by: hsa:6999
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: TDO2
initial amount: NaN
is: SBO:0000252

metaR FACOAL2252
kinetic law: MODEL1310110039#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
name: fatty-acid--CoA ligase
reversible: true
product: MODEL1310110039#
modifier: MODEL1310110039#

metaM ctp e
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00082
type: Species
constant: false
name: CTP(4-)
has only substance units: false
initial concentration: 1.0

metaR 5ADTSTSTERONEte
type: Reaction
is: SBO:0000185
reversible: true
fast: false
name: 5 alpha dihydrotesterone transport
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000

metaR SADT
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: sulfate adenylyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.25
product: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#

metaM c8dc c
name: suberyl carnitine
is: HMDB00791
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H26NO6 CHARGE: -1
constant: false
is: C02838
has only substance units: false
is: SBO:0000247
type: Species

metaR DASPO1p
fast: false
name: D-aspartate oxidase, peroxisomal
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
reactant: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.1
is: SBO:0000176
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#

metaR RE1254C
is described by: ECO:0000000
product: MODEL1310110039#
name: RE1254
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
reactant: MODEL1310110039#

metaR FUMTSULtm
reversible: true
is described by: ECO:0000269
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#

metaM acgam l
initial concentration: 1.0
is: CHEBI:17411
name: N-acetyl-D-glucosamine
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: HMDB00215
has only substance units: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

metaM mal L x
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
initial concentration: 1.0
is: SBO:0000247
name: (S)-malate(2-)
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM ksi pre33 g
has only substance units: false
is: CHEBI:58053
constant: false
is: HMDB00175
type: Species
is: C00130
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 33
initial amount: NaN
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
boundary condition: false
is: SBO:0000247

metaR RE0344C
reversible: true
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
name: RE0344
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR UPP3S
fast: false
reactant: MODEL1310110039#
name: uroporphyrinogen-III synthase
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.75
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is described by: ECO:0000000
product: MODEL1310110039#
reversible: false
type: Reaction
is: SBO:0000176

metaM ala D c
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
name: D-alanine
constant: false
initial concentration: 1.0

metaR AGTim
is described by: ECO:0000269
fast: false
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.6.1.44
type: Reaction
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false

metaM paps g
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: CHEBI:58339
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
constant: false
is: HMDB01134
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaM 3hexdtetcoa x
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 3,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB02288
has only substance units: false

metaR FACOAL2251
reversible: true
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110039#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_3b59307a_5e28_4875_a93e_2521cc2ce8a7
is: P54750
is encoded by: hsa:5136
has only substance units: false
name: PDE1A
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_c4f84a9c_b531_434c_97da_74836515304a
has only substance units: false
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial amount: NaN
constant: false
boundary condition: true
has part: P48201
is encoded by: hsa:518
initial concentration: NaN

metaM HC01401 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:27668
type: Species
initial amount: NaN
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false
constant: false

metaM n2m2nm l
has only substance units: false
initial concentration: 1.0
is: CHEBI:30825
type: Species
notes: FORMULA: C58H97N5O41 CHARGE: 0
constant: false
initial amount: NaN
is: HMDB00573
is: SBO:0000247
name: n2m2nmasn (w/o peptide linkage)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b180f9f7_7141_4591_a0cc_3c2a52adfe6f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:26
constant: false
name: ABP1
is: P19801
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_b075ae2d_8d91_4151_bac8_29e4233b3dee
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:218
name: ALDH3A1
is: P30838
initial concentration: NaN

metaR MAN6PI
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
fast: false
reversible: true
product: MODEL1310110039#
is described by: ECO:0000304
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/5.3.1.8
is: SBO:0000176
modifier: MODEL1310110039#
type: Reaction

metaR R group phosphotase 1
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: R group phosphotase 1
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_c0de38bd_4988_4233_ba69_6b05de335007
initial amount: NaN
is: Q15392
initial concentration: NaN
is encoded by: hsa:1718
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: DHCR24
boundary condition: true

metaM ctp c
boundary condition: false
is: C00063
name: CTP
is: CHEBI:37563
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: HMDB00082
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

http://identifiers.org/biomodels.db/MODEL1310110039#_94c641d1_3713_4c78_8b5a_b24d87c01a21
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: GMPR
is: P36959
has only substance units: false
is encoded by: hsa:2766

metaR S6T4g
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR PCHOLPr hs
reversible: false
kinetic law: MODEL1310110039#
name: choline phosphatase
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is described by: ECO:0000269

metaR GACPAILter
name: glucosaminyl-acylphosphatidylinositol ER flippase
is: SBO:0000185
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000

metaR CITL
is: SBO:0000176
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reversible: false
type: Reaction
name: Citrate lyase
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
modifier: MODEL1310110039#

metaR CERT1gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reactant: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000304
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
fast: false
kinetic law: MODEL1310110039#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_a41a8167_03f8_4410_87e4_24d63d63566e
is: Q59EA4
has only substance units: false
boundary condition: true
initial amount: NaN
name: PLD1
is: SBO:0000252
is encoded by: hsa:5337
type: Species
constant: false
initial concentration: NaN

metaM co c
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB01361
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
has only substance units: false
name: carbon monoxide
is: SBO:0000247
is: CHEBI:17245
initial amount: NaN

metaR ASNNm
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
product: MODEL1310110039#
name: L-asparaginase (mitochondrial)
reversible: false
is described by: ECO:0000254
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.1.1
reactant: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0b4e1b05_cfe1_4e23_b12f_319a81767224
boundary condition: true
constant: false
type: Species
is: B2RD24
is: SBO:0000252
name: MTHFD1L
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:25902

metaM ala D e
is: CHEBI:15570
name: D-alanine
is: HMDB01310
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_de61cf78_560c_4f41_a18d_7442e544682b
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
has only substance units: false
initial concentration: NaN
type: Species
is: P15328
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_55b545d8_15eb_4db2_8f03_85b3b31a1224
initial amount: NaN
is encoded by: hsa:522
initial concentration: NaN
type: Species
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
constant: false
is: SBO:0000297
has part: Q6NZ59
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_328003a7_e27c_44c5_97f9_b532a8a77dc4
initial concentration: NaN
is: SBO:0000252
is: Q16222
initial amount: NaN
boundary condition: true
name: UAP1
type: Species
is encoded by: hsa:6675
has only substance units: false
constant: false

metaR IDOURte
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110039#
name: L-iduronate transport, extracellular
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR FACOAL181i
reversible: false
reactant: MODEL1310110039#
name: C181 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110039#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#

metaM mal L m
is: CHEBI:15589
name: (S)-malate(2-)
is: HMDB00156
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR SUBERCACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaR r2193
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#

metaR HIVCRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR BILGLCURtr
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
name: glucuronidated compound transport

http://identifiers.org/biomodels.db/MODEL1310110039#_11fc9f8a_d6d2_459d_b43e_6ba376b2c70c
is: Q8TDY1
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:8706
name: B3GALNT1
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ksi pre13 g
boundary condition: false
is: C00130
is: HMDB00175
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: CHEBI:58053
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 13
constant: false

metaM pchol hs r
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: CHEBI:16110
name: Phosphatidylcholine
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

metaM paps c
is: HMDB01134
initial amount: NaN
has only substance units: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
boundary condition: false
is: CHEBI:58339
type: Species
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR C181OHc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaR PPAt
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
name: Propionate transport, diffusion
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV

metaR N4Tg
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000000
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction
product: MODEL1310110039#

metaM ac c
name: acetate
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
boundary condition: false
is: SBO:0000247
is: CHEBI:30089
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_1692f935_2b3f_45d3_9d19_e9eb9a62b384
initial concentration: NaN
is: SBO:0000252
is: P32019
type: Species
boundary condition: true
has only substance units: false
name: INPP5B
is encoded by: hsa:3633
constant: false
initial amount: NaN

metaM oaa x
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
is: CHEBI:16452
initial concentration: 1.0
constant: false
is: HMDB00223
is: C00036
initial amount: NaN
has only substance units: false
name: Oxaloacetate
type: Species

metaM tchola c
boundary condition: false
is: CHEBI:36257
name: taurocholic acid
initial amount: NaN
type: Species
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: HMDB00036
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_df67deea_ce23_411b_bbbb_b3576ef546bb
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1798
name: DPAGT1
initial amount: NaN
is: SBO:0000252
is: Q9H3H5
constant: false

metaM cholcoar x
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: HMDB02178
boundary condition: false
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8ee2c4ce_0bbe_4964_91fd_74317157fb36
has only substance units: false
is encoded by: hsa:FLJ44968
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _FLJ44968_1_m
initial amount: NaN
type: Species

metaR UGALNACtg
kinetic law: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110039#
name: UDP-GalNAc Golgi transport via CMP antiport
is described by: ECO:0000269
fast: false
product: MODEL1310110039#
type: Reaction
reversible: true

metaR r0068
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.2.1
type: Reaction
reactant: MODEL1310110039#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_df3da0e2_8c55_40ef_87a8_8741adb918e0
is: SBO:0000297
is encoded by: hsa:23439
initial concentration: NaN
initial amount: NaN
has only substance units: false
has part: P50993
type: Species
has part: Q9UN42
constant: false
name: ATP1B4:ATP1A2
is encoded by: hsa:477
boundary condition: true

metaR NDPK1m
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110039#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r2195
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185

metaR PI45P5P
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110039#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110039#

metaR DHCHOLESTANATEtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: lipid, flip-flop intracellular transport
type: Reaction
fast: false
product: MODEL1310110039#

metaR AIRCr
kinetic law: MODEL1310110039#
name: phosphoribosylaminoimidazole carboxylase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.3.2.6
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110039#_dc684d01_8ebd_47ab_9cd9_280995129f11
initial amount: NaN
boundary condition: true
is: Q14117
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: DPYS
type: Species
constant: false
is encoded by: hsa:1807

http://identifiers.org/biomodels.db/MODEL1310110039#_9b88fe43_e25f_450a_a0af_61a3f3e9b89e
type: Species
initial concentration: NaN
is encoded by: hsa:5313
constant: false
has only substance units: false
boundary condition: true
is: P30613
initial amount: NaN
is: SBO:0000252
name: PKLR

metaM dhap x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
type: Species
initial amount: NaN
is: C00111
is: HMDB01473
constant: false
has only substance units: false
name: Dihydroxyacetone phosphate
boundary condition: false
initial concentration: 1.0
is: CHEBI:57642

metaM glyc3p c
is: SBO:0000247
initial amount: NaN
is: CHEBI:57597
is: C00093
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00126
constant: false
boundary condition: false
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_65111caa_6839_4ace_8dda_618c5874d37c
is: P30837
is: SBO:0000252
name: ALDH1B1
initial amount: NaN
is encoded by: hsa:219
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_0feedd7a_1087_4567_a6b3_37d5042c8d37
type: Species
is encoded by: hsa:8527
name: DGKD
is: Q16760
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1ce72b84_92d3_4cad_b4fe_559f77434bd1
name: _BF195998_1_x
is encoded by: hsa:BF195998
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaR NDPK1n
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000134
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110039#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear

metaR SBT Dtde
fast: false
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110039#
name: D-sorbitol transport, extracellular
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110039#
type: Reaction

metaM h2o2 x
is: CHEBI:16240
boundary condition: false
initial amount: NaN
is: C00027
type: Species
is: HMDB03125
constant: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
is: SBO:0000247
name: Hydrogen peroxide

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM digalside hs c
name: Digalactosylceramide
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/8383
has only substance units: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
is: C06126
is: SBO:0000247

metaR r2196
modifier: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_b3903eb0_4120_483c_b6e6_c41861fb99cc
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:BE042354
initial concentration: NaN
constant: false
initial amount: NaN
name: _BE042354_1_m

metaR r0817
product: MODEL1310110039#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false

metaM tchola e
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: taurocholic acid
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_433f8300_76a9_4ad0_ae81_c60536a53827
constant: false
initial amount: NaN
type: Species
name: B4GALT3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8703
boundary condition: true
is: A8K5Z0
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_4459f7a1_be9e_48de_a514_cf921ca5a574
constant: false
type: Species
initial amount: NaN
name: TKT
is encoded by: hsa:7086
is: E7EPA7
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR OCD11COACPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR r2197
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaR SIAT4Bg
modifier: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.99.4

metaM 3octdece1coa c
is: SBO:0000247
constant: false
has only substance units: false
name: 3-hydroxyoctadecenoylcoa
initial amount: NaN
is: HMDB00712
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_869672a3_3c79_425a_a837_0cd8adc82c71
initial concentration: NaN
is encoded by: hsa:55229
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
name: PANK4
is: SBO:0000252
is: Q9NVE7

http://identifiers.org/biomodels.db/MODEL1310110039#_52f2ab66_3f85_4f0a_ad68_4f74a934574c
is encoded by: hsa:3712
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: IVD
is: SBO:0000252
is: B3KVI7

metaR FACOAL1831
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110039#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110039#

metaM HC02187 c
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
name: reverse-triiodthyronine
initial concentration: 1.0
boundary condition: false
is: CHEBI:28774
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

metaR MDHm
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
name: malate dehydrogenase, mitochondrial
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.37
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110039#_a9973f16_1bf3_4479_bd82_5241cbea77c3
type: Species
is: P20933
name: AGA
boundary condition: true
is encoded by: hsa:175
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false

metaR r2198
is: SBO:0000185
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
reactant: MODEL1310110039#
fast: false

metaR RE1519M
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110039#
name: RE1519
reactant: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
reversible: true

metaR r0789
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110039#
product: MODEL1310110039#

metaM eicostetcrn m
type: Species
is: HMDB01356
name: Eicosatetranoyl carnitine
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57312
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
initial amount: NaN
has only substance units: false

metaR ANDRSTRNte
reactant: MODEL1310110039#
name: androsterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR ACACt2
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110039#
reversible: true
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: acetoacetate transport via proton symport
is: SBO:0000185
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_4ce1753e_635e_47b6_b1c3_33e1f831757f
is encoded by: hsa:8818
has part: Q14442
is encoded by: hsa:9091
is: SBO:0000297
is encoded by: hsa:5283
type: Species
boundary condition: true
has part: B3KUV7
is encoded by: hsa:5277
initial amount: NaN
has only substance units: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
has part: Q92535
has part: Q9BRB3
is encoded by: hsa:5279
has part: O94777
initial concentration: NaN
is encoded by: hsa:51227

metaR FACOAL1832
kinetic law: MODEL1310110039#
fast: false
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
reversible: true
modifier: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
is: SBO:0000176

metaR NDP7er
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110039#

metaM o2s c
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
initial concentration: 1.0
name: superoxide
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:18421
initial amount: NaN
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110039#_5841f993_474a_4e12_b25f_24a0c04cf83a
is encoded by: hsa:6487
initial concentration: NaN
type: Species
name: ST3GAL3
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_e3aecefb_d22a_4cbb_bf9e_2b12212435ab
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: B4GALT5
type: Species
constant: false
initial concentration: NaN
is: O43286
is encoded by: hsa:9334
has only substance units: false

metaR r0819
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaR r0788
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR r2199
modifier: MODEL1310110039#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110039#
reversible: true

metaM 3hdcoa c
initial amount: NaN
has only substance units: false
name: (S)-3-Hydroxydecanoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
type: Species
is: HMDB00651
is: SBO:0000247
constant: false

metaR FAOXC164x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM m7mpdol U r
boundary condition: false
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
type: Species
is: SBO:0000247
constant: false
is: CHEBI:37636
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_4d61474a_2a90_40c8_8612_ae7ab85e470f
constant: false
is: Q06203
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5471
name: PPAT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_b8aec02e_c337_445c_b1ec_1e0c4bc081b8
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:4720
is: B7Z792
name: NDUFS2
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_d3c699b2_000b_4ddd_9dee_6ad06ecb13e3
initial amount: NaN
is: Q99999
is: SBO:0000252
constant: false
has only substance units: false
name: GAL3ST1
type: Species
is encoded by: hsa:9514
initial concentration: NaN
boundary condition: true

metaR RE3565C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
type: Reaction
name: RE3565
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176

metaM udpacgal c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
initial concentration: 1.0
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57847

metaR G14T7g
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110039#

metaR FAOXC81C61x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_e2624771_ef7b_4a21_84a9_89474a142913
constant: false
initial amount: NaN
type: Species
is: Q9NR34
initial concentration: NaN
name: MAN1C1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57134
boundary condition: true

metaM acgam r
initial concentration: 1.0
is: HMDB00215
constant: false
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
is: CHEBI:17411
name: N-acetyl-D-glucosamine
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM HC02187 e
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
name: reverse-triiodthyronine
boundary condition: false

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaR r0818
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:

metaR r0787
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110039#
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
modifier: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
fast: false
reversible: false
product: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_b26b5195_bd44_401e_87ab_2d6262913e98
constant: false
type: Species
is: SBO:0000252
name: SLC9A4
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:389015
boundary condition: true
is: Q6AI14
has only substance units: false

metaM digalside hs g
is: C06126
is: SBO:0000247
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/8383
initial amount: NaN
name: Digalactosylceramide

metaR DOLMANP Lter
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: false
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol-phosphate mannose flippase (liver)

metaM ttdca e
initial amount: NaN
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
type: Species
has only substance units: false
constant: false
name: tetradecanoate (n-C14:0)
is: CHEBI:30807
is: HMDB00806
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C06424

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR HEX7
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
name: hexokinase (D-fructose:ATP)
is described by: ECO:0000304
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
reactant: MODEL1310110039#

metaR r1495
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
reactant: MODEL1310110039#
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110039#

metaR RE1342C
product: MODEL1310110039#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
name: RE1342
fast: false
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_36aa8112_69b7_43f7_bab2_92aef7dd7986
is encoded by: hsa:480
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: ATP1A4
type: Species
is: Q13733

http://identifiers.org/biomodels.db/MODEL1310110039#_de06e81b_b449_4313_96e6_4cdeac201161
is encoded by: hsa:1374
type: Species
constant: false
initial amount: NaN
name: CPT1A
is: Q8WZ48
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR S6TASE24ly
reactant: MODEL1310110039#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110039#
modifier: MODEL1310110039#

metaR SGALSIDEtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: sgalside hs intracellular transport
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_cac671c0_ac80_4c08_8c0e_6ec1548464ae
is: Q16795
is encoded by: hsa:4704
boundary condition: true
type: Species
name: NDUFA9
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM CE5586 c
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58732
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
type: Species
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_d3453d7d_2bf5_4513_8db5_0343c7e0639b
boundary condition: true
name: HSD17B4
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: E9PB82
is encoded by: hsa:3295
has only substance units: false

metaM 3dsphgn c
is: HMDB01480
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58299

http://identifiers.org/biomodels.db/MODEL1310110039#_a8c32c41_ca5a_4840_a583_ad2a6ed2010f
has only substance units: false
name: BCAT2
is encoded by: hsa:587
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: O15382

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_f54a1a27_6f91_4c64_ac13_19cfffa9bf06
initial amount: NaN
is encoded by: hsa:79695
is: SBO:0000252
is: Q8IXK2
constant: false
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: GALNT12

metaR RE0830N
reactant: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
name: RE0830
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.96

http://identifiers.org/biomodels.db/MODEL1310110039#_063df003_e147_4f8f_ade2_b59d75b845f1
initial amount: NaN
type: Species
name: DGKD
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8527
boundary condition: true
constant: false

metaM retinol 9 cis c
is: CHEBI:17336
type: Species
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: SBO:0000247
constant: false
is: HMDB06217
initial amount: NaN
boundary condition: false
name: 9-cis-retinol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_29adcaef_4874_4178_adc6_e3334a6953e8
is encoded by: hsa:284273
initial amount: NaN
boundary condition: true
name: ZADH2
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q4G1C4

metaR r0081
type: Reaction
is described by: ECO:0000000
fast: false
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
modifier: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_93637c34_310d_44fe_ae9a_fa9771eba603
boundary condition: true
initial amount: NaN
constant: false
name: AMY1C
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P04745
type: Species
is encoded by: hsa:278

metaM abt e
type: Species
is: HMDB01851
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:18403
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
constant: false

metaR TCHOLAtx
kinetic law: MODEL1310110039#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
is: HMDB00071
boundary condition: false
name: Deoxyinosine
initial concentration: 1.0
constant: false
is: C05512
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28997

metaR THRGLNexR
is: SBO:0000185
product: MODEL1310110039#
is described by: ECO:0000304
kinetic law: MODEL1310110039#
fast: false
name: L-threonine/glycine reversible exchange
type: Reaction
reversible: true
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_875dbe67_2abd_4048_b44c_8f584a5f1290
is: P00558
is encoded by: hsa:5230
name: PGK1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR IVCOAACBP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR r1493
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
name: Utilized transport
reversible: false
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaM asp D x
initial concentration: 1.0
name: D-aspartate(1-)
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial amount: NaN
is: CHEBI:29990
is: SBO:0000247
type: Species
is: HMDB06483
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_709b491e_c0b4_4954_89df_32395c8f20c4
name: ALDH1A2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8854
initial amount: NaN
is: O94788
boundary condition: true
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_351f6e4f_8790_4ce1_90b9_a4122538d148
type: Species
initial concentration: NaN
is encoded by: hsa:53354
is: SBO:0000252
constant: false
boundary condition: true
name: PANK1
has only substance units: false
initial amount: NaN

metaM ctp m
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00082
name: CTP(4-)
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaM succ x
is: SBO:0000247
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
is: CHEBI:30031
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00254
constant: false
type: Species
is: C00042

http://identifiers.org/biomodels.db/MODEL1310110039#_8ac03ada_8b70_445e_8e53_9992eea7fd1c
is encoded by: hsa:J03866
boundary condition: true
is: SBO:0000252
constant: false
name: _J03866_1_m
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM 5oxpro c
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: HMDB00267
is: CHEBI:57606
is: SBO:0000247
initial amount: NaN
name: 5-oxoprolinate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_7aa178dd_c2ce_41e9_951a_cb2fbbab5d81
initial amount: NaN
has only substance units: false
is: B2RAU6
boundary condition: true
name: PIGQ
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9091

metaM strdnccoa m
type: Species
is: HMDB06519
initial amount: NaN
name: stearidonyl coenzyme A
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
constant: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205473
is: C16163

metaR S6T16g
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is described by: ECO:0000000

metaM docoscoa x
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB12930
initial amount: NaN
name: docosanoylcoa
has only substance units: false
constant: false
notes: FORMULA: C43H74N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110039#_dbc4886c_8d6b_4337_8be9_48a78abb554a
constant: false
has only substance units: false
name: DGKZ
boundary condition: true
is: G3V0F6
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8525
initial amount: NaN

metaR r1492
fast: false
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110039#
is: SBO:0000185
name: Utilized transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#

metaR r0083
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: true
kinetic law: MODEL1310110039#

metaR FAOXC2252053m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR NAt3 1
type: Reaction
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000269
name: sodium proton antiporter (H:NA is 1:1)
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reversible: true
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#

metaM C02528 c
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
is: HMDB00518
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:36234
has only substance units: false

metaM Lfmkynr c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01200
is: CHEBI:30249
name: N-formyl-L-kynurenine
type: Species
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8660fce8_ac3a_4908_a2f3_2b8716d9ac02
boundary condition: true
is encoded by: hsa:271
initial concentration: NaN
constant: false
initial amount: NaN
is: E9PNG0
is: SBO:0000252
type: Species
name: AMPD2
has only substance units: false

metaM ctp n
is: SBO:0000247
type: Species
is: CHEBI:37563
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
boundary condition: false
name: CTP(4-)
initial concentration: 1.0

metaR TSTSTERONEtr
name: testosterone intracellular transport
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#

metaM glyc c
is: SBO:0000247
is: CHEBI:17754
constant: false
type: Species
initial amount: NaN
is: HMDB00131
boundary condition: false
name: Glycerol
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
initial concentration: 1.0

metaM HC10852 r
name: palmitoleyl-CoA(4-)
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:61540

metaR EX digalsgalside hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Digalactosylceramidesulfate exchange
type: Reaction

metaM abt c
name: L-arabinitol
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB01851
is: CHEBI:18403
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_11e37327_1cdc_4ce8_b604_c7a8e81277c8
has only substance units: false
name: FUK
initial concentration: NaN
is encoded by: hsa:197258
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is: Q8N0W3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_ad6822b3_6c18_411e_b57d_217dbad968a6
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4698
has only substance units: false
name: NDUFA5
is: Q16718

metaR LNLCCRNt
reversible: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#

metaM galgluside hs g
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: galactosyl glucosyl ceramide
initial amount: NaN
is: C00015
boundary condition: false
has only substance units: false
is: HMDB00295
is: CHEBI:58223
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162

http://identifiers.org/biomodels.db/MODEL1310110039#_5cbfd241_a6b0_4e9e_913e_2d44d7e0db4f
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: P48200
boundary condition: true
type: Species
is encoded by: hsa:3658
initial amount: NaN
name: IREB2

metaR CYANtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
type: Reaction
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
name: Cyanide transport via diffusion (mitochondrial)
reversible: true
is: SBO:0000185
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR r0354
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110039#
is described by: ECO:0000000

metaR PTPATe
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
name: PTPATe
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_23f8597b_d0e8_4827_9b36_565b2ba9971f
is encoded by: hsa:377677
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q8N1Q1
constant: false
initial concentration: NaN
name: CA13
is: SBO:0000252
type: Species

metaR r2139
fast: false
kinetic law: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110039#
is: SBO:0000185

metaR S6TASE5ly
is described by: ECO:0000000
modifier: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: N-acetylgalactosamine-6-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM 5oxpro e
initial concentration: 1.0
constant: false
is: HMDB00267
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57606
type: Species
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
name: 5-oxoprolinate

metaR C204CPT2
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
kinetic law: MODEL1310110039#
name: arachidonic acid transport into the mitochondria
reversible: false
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction

metaR SGALSIDEtl
name: sgalside hs intracellular transport
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: true
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
product: MODEL1310110039#
fast: false
is described by: ECO:0000000

metaR NACHEX1ly
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110039#

metaM C02528 e
has only substance units: false
is: HMDB00518
is: SBO:0000247
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
initial amount: NaN
constant: false
name: chenodeoxycholate
is: CHEBI:36234
type: Species
initial concentration: 1.0

metaM cs b deg2 l
notes: FORMULA: C37H54NO41S3 CHARGE: -5
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57455
is: HMDB01354

metaM tsul e
has only substance units: false
boundary condition: false
is: CHEBI:16094
initial concentration: 1.0
initial amount: NaN
name: thiosulfate(2-)
type: Species
is: HMDB00257
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false
is: SBO:0000247

metaM c6dc x
has only substance units: false
is: SBO:0000247
name: adipoyl carnitine
is: C14143
is: HMDB04047
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1

metaR HEX4
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
name: hexokinase (D-mannose:ATP)
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaM CE4876 r
initial amount: NaN
name: delta12-Prostaglandin J2
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

metaR CYTK10n
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
name: cytidylate kinase (CMP,dGTP),nuclear
kinetic law: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_281c19db_631b_43d7_92b2_58dca00020ab
type: Species
initial concentration: NaN
is encoded by: hsa:80724
boundary condition: true
is: G3XAJ0
name: ACAD10
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR RTOTALt
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110039#
is described by: ECO:0000000
reversible: true
name: RTOTAL transport

metaM dtmp c
is: HMDB01227
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: dTMP
type: Species
is: CHEBI:26999
has only substance units: false

metaR DDECCRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR TMNDNCCPT1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
modifier: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
name: carnitine O-palmitoyltransferase

metaR CMPSAS
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
name: CMP sialic acid synthase
reactant: MODEL1310110039#
reversible: false
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.7.43
is described by: ECO:0000304
modifier: MODEL1310110039#

metaR NACHEX8ly
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#

metaR r2137
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_3b246550_3094_4a45_9357_e9adb8566ff0
name: MTHFR
constant: false
is: SBO:0000252
is encoded by: hsa:4524
is: Q59GJ6
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR r1880
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaR DHAAt1r
name: dehydroascorbate transport (uniport)
type: Reaction
reversible: true
modifier: MODEL1310110039#
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110039#

metaR SPRMS
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.22
name: spermine synthase
reversible: false

metaM sucsal m
is: HMDB01259
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
has only substance units: false
boundary condition: false
is: CHEBI:57706
name: Succinic semialdehyde
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaM g1m8mpdol U r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
boundary condition: false
is: CHEBI:59093
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20

metaM pyam5p c
initial concentration: 1.0
is: CHEBI:58451
is: C00647
initial amount: NaN
type: Species
is: HMDB01555
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
name: Pyridoxamine 5'-phosphate

http://identifiers.org/biomodels.db/MODEL1310110039#_afb95934_2f62_45f6_813f_4097682732f1
name: PDE8B
type: Species
is: SBO:0000252
is: O95263
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8622
boundary condition: true
initial amount: NaN
constant: false

metaM acnamp c
name: N-Acetylneuraminate 9-phosphate
boundary condition: false
initial concentration: 1.0
is: HMDB06268
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:27438
is: SBO:0000247
type: Species
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241

metaR TMNDNCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
name: carnitine transferase
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_b8462660_4a99_45d0_8ca4_9c8c30d0c667
has only substance units: false
is encoded by: hsa:2023
initial amount: NaN
name: ENO1
initial concentration: NaN
boundary condition: true
is: E2DRY6
constant: false
type: Species
is: SBO:0000252

metaR r1881
is described by: ECO:0000000
modifier: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110039#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110039#

metaM hdca r
boundary condition: false
is: HMDB00220
type: Species
has only substance units: false
name: Hexadecanoate (n-C16:0)
is: CHEBI:7896
initial concentration: 1.0
is: C00249
constant: false
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247

metaR HEX1
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
name: hexokinase (D-glucose:ATP)
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR D LACt2
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction
is: SBO:0000185
name: D-lactate transport via proton symport
is described by: ECO:0000269
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110039#
reversible: true
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
product: MODEL1310110039#

metaM CE2433 m
has only substance units: false
constant: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
type: Species
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR SCP21cx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_d632362f_8115_4881_a0b3_41844b737e51
name: SLC15A2
constant: false
has only substance units: false
initial amount: NaN
is: Q16348
type: Species
is encoded by: hsa:6565
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_400a090d_0a08_41c6_858a_511b5c75f445
type: Species
boundary condition: true
is: Q16853
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8639
is: SBO:0000252
constant: false
name: AOC3

metaM dcsptn1coa c
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false
is: SBO:0000247
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
initial concentration: 1.0

metaR NDPK5
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_59fd79ae_d77c_4323_b66e_d1d91dd5ab5d
is: Q8TCD5
is encoded by: hsa:30833
type: Species
name: NT5C
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR ADK1m
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
name: adenylate kinase, mitochondrial
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD

metaR ACSm
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
name: acetyl-CoA synthetase
reversible: false
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false

metaM ksi pre21 g
is: SBO:0000247
is: CHEBI:58053
is: C00130
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
name: keratan sulfate I biosynthesis, precursor 21
initial concentration: 1.0
constant: false
type: Species
is: HMDB00175
has only substance units: false
boundary condition: false
initial amount: NaN

metaM sphings c
constant: false
is: SBO:0000247
is: CHEBI:57756
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: HMDB00252
name: sphingosine(1+)
boundary condition: false
type: Species
initial amount: NaN

metaR DIGALSGALSIDEtg
name: digalsgalside hs intracellular transport
reversible: true
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110039#
fast: false

metaR HS2ly
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.10.1.1

metaM phytcoa x
has only substance units: false
is: HMDB01359
is: SBO:0000247
name: phytanoyl-CoA(4-)
type: Species
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaR EX oagt3 hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GT3 (homo sapiens) exchange
type: Reaction

metaR NDPK4
is described by: ECO:0000269
product: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM bilglcur c
is: CHEBI:57767
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR PTDCAt
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
type: Reaction
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110039#_132bc0b1_546a_447d_8866_fb73a1dcf7b5
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI694761_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI694761

http://identifiers.org/biomodels.db/MODEL1310110039#_52956765_5401_46c0_8434_5039c44720b9
initial concentration: NaN
type: Species
is encoded by: hsa:6713
boundary condition: true
constant: false
name: SQLE
is: Q5HYI4
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR GLCNACPT U
is described by: ECO:0000000
reversible: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
is version of: http://identifiers.org/ec-code/2.7.8.15
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM ascb L c
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00044
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
name: L-ascorbate
initial amount: NaN
boundary condition: false

metaM but c
is: CHEBI:17968
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
name: butyrate
constant: false

metaR NACHEX18ly
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
reversible: false
modifier: MODEL1310110039#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR RE3218C
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
name: RE3218
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.2
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton

metaM g3p c
constant: false
is: CHEBI:58027
is: C00661
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
name: Glyceraldehyde 3-phosphate
is: http://identifiers.org/pubchem.compound/3930
boundary condition: false
has only substance units: false
is: HMDB01112

metaR SUCCt2m
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: succinate transport, mitochondrial
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110039#
is described by: ECO:0000269
kinetic law: MODEL1310110039#

metaM ptrc c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial amount: NaN
is: HMDB01414
boundary condition: false
type: Species
is: C00134
name: Putrescine
constant: false
is: CHEBI:326268
initial concentration: 1.0

metaM eicostetcrn c
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: HMDB01356
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57312
constant: false
name: Eicosatetranoyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a71c9934_6c5e_48bd_ad7c_06940b5b352f
is: Q9H477
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:64080
name: RBKS

metaR FAOXC12DCTc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR DTMPK
modifier: MODEL1310110039#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.9
product: MODEL1310110039#
name: dTMP kinase
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaR NDPK7
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dCDP)
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110039#
is: SBO:0000176

metaM ksii core4 deg1 l
constant: false
is: CHEBI:57737
initial concentration: 1.0
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 4-linked), degradation product 1
is: HMDB00868
initial amount: NaN
has only substance units: false
type: Species

metaM ksii core2 deg8 l
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 8
is: HMDB00143
constant: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
boundary condition: false

metaM cytd m
name: cytidine
type: Species
constant: false
is: HMDB00089
is: CHEBI:17562
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
has only substance units: false
initial concentration: 1.0

metaR GCCbim
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110039#
product: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110039#_106a3432_f6bc_421e_a2e8_2f9b7ddaeba3
initial concentration: NaN
constant: false
is encoded by: hsa:5277
is encoded by: hsa:8818
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
is: SBO:0000297
boundary condition: true
type: Species
has part: P37287

http://identifiers.org/biomodels.db/MODEL1310110039#_8f0f4b7b_b53e_42c2_9a2a_c576bbaf7255
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AI620219
initial amount: NaN
name: _AI620219_1_c
constant: false

metaR RE0915E
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: RE0915
fast: false
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110039#_12ec1b75_2ed8_4888_9194_e67d72bf71b3
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2597
is: E7EUT4
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GAPDH

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM hxcoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB06522
is: SBO:0000247
has only substance units: false
constant: false
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
type: Species

metaR DIGALSGALSIDEte
fast: false
is: SBO:0000185
reactant: MODEL1310110039#
name: digalsgalside hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR r1779
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185

metaR PSYGCHe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_3c176b8c_dcec_47fc_84ee_8a6e57744e20
name: NDUFA1
constant: false
is: Q6IBB5
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4694
is: SBO:0000252

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM dcacoa x
is: SBO:0000247
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
initial amount: NaN
constant: false
is: CHEBI:61430
has only substance units: false

metaR PPDOx
reactant: MODEL1310110039#
reversible: false
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
product: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_4ef5b674_cdc6_4554_abd6_743873b1902c
is: SBO:0000252
initial concentration: NaN
name: DLAT
type: Species
is: Q86YI5
initial amount: NaN
is encoded by: hsa:1737
constant: false
has only substance units: false
boundary condition: true

metaR FAOXC164C165m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM acrn x
is: CHEBI:57589
constant: false
name: O-acetylcarnitine
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00201
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

http://identifiers.org/biomodels.db/MODEL1310110039#_9ac79bd3_5e57_487d_8094_e18ff5e2ffc8
name: PTDSS1
has only substance units: false
is encoded by: hsa:9791
constant: false
is: P48651
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR NDPK6
product: MODEL1310110039#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is: SBO:0000176
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8ffdce6a_81c6_4975_bb51_1aebd3587534
initial amount: NaN
is: Q9BRB3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9091
name: PIGQ
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_221e54e7_0fab_4917_81ec_83e4f00ca142
boundary condition: true
has only substance units: false
name: CHST2
constant: false
is encoded by: hsa:9435
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9Y4C5

http://identifiers.org/biomodels.db/MODEL1310110039#_928ccee3_7872_4f00_a154_0876348eb73f
is: SBO:0000297
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:9517
is encoded by: hsa:10558
name: SPTLC1:SPTLC2
initial concentration: NaN
type: Species
has part: O15270
initial amount: NaN
has part: O15269

http://identifiers.org/biomodels.db/MODEL1310110039#_67966baa_e50d_4cba_97f1_9e1ec47a637b
initial concentration: NaN
name: ALG1
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is: Q9BT22
type: Species
is encoded by: hsa:56052
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e88a0f0a_302b_4bbe_bc33_19ecdfacbaf3
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: Q08ET0
is encoded by: hsa:515
type: Species
name: ATP5F1

http://identifiers.org/biomodels.db/MODEL1310110039#_517af864_cee3_4e95_91fe_c09d33c2056b
type: Species
is encoded by: hsa:84720
constant: false
initial amount: NaN
boundary condition: true
name: PIGO
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR 10FTHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
fast: false
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true
type: Reaction

metaM ptrc e
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01414
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:326268
name: Putrescine
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
has only substance units: false

metaR r0355
fast: false
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaR PPDOy
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.21
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is described by: ECO:0000269
reactant: MODEL1310110039#
modifier: MODEL1310110039#

metaM hedepecoa m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
type: Species
constant: false
boundary condition: false
is: HMDB02288
name: 2,4,7,10,13-hexadecapentenoylcoa

metaM tymsf c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: Tyramine O-sulfate
initial amount: NaN
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: HMDB06409
boundary condition: false

metaR NDPK9
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP)
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110039#
reversible: true
is: SBO:0000176

metaR ALDD2x
is described by: ECO:0000000
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110039#
fast: false
reversible: false
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#

metaM c51crn e
initial amount: NaN
notes: FORMULA: C12H21NO4 CHARGE: 0
constant: false
name: tiglyl carnitine
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB02366

metaR RE0830C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
reversible: true
name: RE0830
is described by: ECO:0000000
product: MODEL1310110039#
fast: false

metaR r0084
is described by: ECO:0000000
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110039#
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110039#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b1bf12f8_5418_41d6_abe9_c64a0593769d
is encoded by: hsa:10201
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: O75414
name: NME6
is: SBO:0000252
boundary condition: true

metaR FAOXC204
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000269

metaM tsul m
is: SBO:0000247
is: HMDB00257
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
has only substance units: false

metaR NDPK8
type: Reaction
is described by: ECO:0000269
product: MODEL1310110039#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
name: Nucleoside-diphosphate kinase (ATP:dADP)
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110039#_a0f655a2_5b45_41da_a0db_eda94214a77b
is: Q9BZX2
has only substance units: false
is encoded by: hsa:7371
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
name: UCK2

metaR r0085
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR G12MT1 U
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110039#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000000
fast: false

metaR IZPN
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: Imidazolonepropionase
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM strdnccoa c
has only substance units: false
name: stearidonyl coenzyme A
is: HMDB06519
is: C16163
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205473

http://identifiers.org/biomodels.db/MODEL1310110039#_e82b72f8_2e34_474e_8477_fb09d222f992
has only substance units: false
is encoded by: hsa:788
is: SBO:0000252
name: SLC25A20
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: O43772

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR C3STDH1r
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.170
is: SBO:0000176
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)

metaR THRGLNNaEx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: L-threonine/L-glutamine Na-dependent exchange (Thr-L in)

metaM CE2434 m
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial concentration: 1.0
is: CHEBI:57795
has only substance units: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_1757845e_69f3_406a_8963_a6215aeef4f3
is encoded by: hsa:AL038231
boundary condition: true
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AL038231_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_44fb4364_430d_4c33_9523_b4ed794d26ef
constant: false
has part: Q07326
boundary condition: true
type: Species
has part: Q8TEQ8
name: PIGF:PIGO
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:5281
is encoded by: hsa:84720
has only substance units: false

metaM c51crn c
constant: false
notes: FORMULA: C12H21NO4 CHARGE: 0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02366
name: tiglyl carnitine
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_877bbb0f_1c56_452a_80eb_3b6d56307459
name: _C7orf24_1_m
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:C7orf24
has only substance units: false
constant: false

metaM acrn r
type: Species
name: O-acetylcarnitine
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57589
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f36888c8_2038_48e2_a3a2_46e8702c12a0
constant: false
name: ALPP
is: P05187
type: Species
is encoded by: hsa:250
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r0086
modifier: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110039#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#

metaM tymsf e
is: HMDB06409
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: Tyramine O-sulfate
type: Species
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)

http://identifiers.org/biomodels.db/MODEL1310110039#_a41b1de6_4475_474d_bd35_1f8ede62e870
initial amount: NaN
is encoded by: hsa:79611
name: ACSS3
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: Q9H6R3

metaM ascb L e
constant: false
boundary condition: false
has only substance units: false
is: HMDB00044
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
is: CHEBI:38290
initial amount: NaN
name: L-ascorbate
is: SBO:0000247
type: Species

metaR BILIRUBt2
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110039#

metaM din c
name: Deoxyinosine
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:28997
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C05512
is: HMDB00071

http://identifiers.org/biomodels.db/MODEL1310110039#_c839f055_3df5_4fec_a692_7d7870773722
is encoded by: hsa:3612
initial amount: NaN
is: B7Z6Q4
constant: false
has only substance units: false
name: IMPA1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
initial concentration: 1.0
is: CHEBI:57767

metaR r1994
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000

metaM sbcoa c
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00791
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: C02838
name: suberylcoa

http://identifiers.org/biomodels.db/MODEL1310110039#_ed2fcda3_7610_4104_9f08_874b7ec88b23
name: GALNT7
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51809
is: Q86SF2
type: Species

metaR HISTAtu
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
name: Histamine uniport
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
fast: false
type: Reaction
modifier: MODEL1310110039#

metaM cs c deg4 l
is: CHEBI:57455
is: HMDB01354
boundary condition: false
has only substance units: false
notes: FORMULA: C31H49NO29S CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 4
constant: false
initial amount: NaN
type: Species

metaR r1661
kinetic law: MODEL1310110039#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_d7134c44_8671_43a6_a2a8_3c8b525633ee
is: P51648
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ALDH3A2
is encoded by: hsa:224
initial amount: NaN

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
reactant: MODEL1310110039#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
reversible: true

metaR DURAD
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110039#
name: dihydrouracil dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaR UDPDOLPT L
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.117
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
modifier: MODEL1310110039#
reversible: false
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

metaR SCP2x
modifier: MODEL1310110039#
name: peroxisomal thiolase 2
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110039#

metaR r1774
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110039#

metaR r2140
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_1a438643_0fc3_4778_9ac9_f63f8957313c
is: Q92820
name: GGH
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:8836
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_7d8cc6dc_cdc9_4984_ad6e_27a3dcf0a923
is encoded by: hsa:23475
is: Q15274
initial concentration: NaN
initial amount: NaN
constant: false
name: QPRT
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM hexdicoa c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB02014
constant: false
initial amount: NaN
name: hexadecanedioylcoa
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species

metaR r1660
is described by: ECO:0000000
fast: false
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#

metaR BMTer L
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
fast: false
name: B mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
reversible: false
product: MODEL1310110039#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM lac L x
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16651
is: HMDB00190
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: (S)-lactate

metaR FAOXC61x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaM hdca e
has only substance units: false
initial amount: NaN
type: Species
is: C00249
is: SBO:0000247
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
is: HMDB00220
is: CHEBI:0
boundary condition: false
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false

metaR EX 3hdececrn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaR FUT34g
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.65
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
reversible: false
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
modifier: MODEL1310110039#
fast: false

metaR MI4PP
is version of: http://identifiers.org/ec-code/3.1.3.25
product: MODEL1310110039#
name: myo-inositol 4-phosphatase
is: SBO:0000176
reactant: MODEL1310110039#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
kinetic law: MODEL1310110039#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110039#

metaM CE5786 e
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: kinetensin
is: SBO:0000247
is: HMDB02710
type: Species
initial amount: NaN
is: CHEBI:27485
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786

metaR TYMSFt
reversible: false
name: Tyramine O-sulfate transport (diffusion)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_dc11c4bb_e6f1_4ed4_b161_74c1158d0024
boundary condition: true
constant: false
is: O94778
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:343
initial concentration: NaN
name: AQP8
type: Species

metaM cs a deg2 l
is: CHEBI:15748
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM cspg a l
is: CHEBI:36005
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
is: HMDB02183
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
type: Species
has only substance units: false

metaM HC01412 m
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
constant: false
name: trans-tetradec-2-enoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_fc1f98a8_3ab0_46e1_887b_74838ca1f2c1
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q02218
is encoded by: hsa:4967
name: OGDH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_342e3e23_b64b_41b2_b4f8_3ef214bb9aa6
is encoded by: hsa:AI373818
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: _AI373818_1_m
constant: false
initial concentration: NaN
has only substance units: false

metaM dtmp m
is: SBO:0000247
is: HMDB01227
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
name: dTMP
is: C00364
type: Species
has only substance units: false
is: CHEBI:26999

metaM ppi r
boundary condition: false
name: Diphosphate
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species
is: CHEBI:33019
constant: false
has only substance units: false
is: C00013
initial amount: NaN
initial concentration: 1.0

metaM hxcoa c
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB13130

metaM s2l2n2m2masn l
initial amount: NaN
name: de-Fuc form of PA6
constant: false
is: SBO:0000247
is: HMDB00174
boundary condition: false
is: CHEBI:18287
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C84H135N6O61X CHARGE: -2

metaR TTDCAtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
name: tetradecanoate (transport)
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
type: Reaction

metaM malt c
is: C00208
is: SBO:0000247
is: HMDB00163
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
name: Maltose
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:17306

metaR FAOXC225C226m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b23532e5_eae9_4eb1_a225_2592df31e2a4
name: SLC3A2
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:6520
is: P08195
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_1d9ce1b4_16db_4950_b2f4_3f19fcd59ddb
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80308
name: FLAD1
has only substance units: false
boundary condition: true

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_7764c15e_d5ef_4aa1_8407_68e00d2373f5
name: VNN3
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:55350
boundary condition: true
constant: false

metaR RE3367E
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: RE3367
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_738839cc_c615_4f7d_870e_86e286eacf17
name: _H45672_1_m
constant: false
is encoded by: hsa:H45672
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_3abb1229_5f1a_4d42_9553_4bb4d4f5b383
boundary condition: true
has only substance units: false
is: Q9NTN3
name: SLC35D1
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:23169
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_a95b1b80_798b_450e_8f15_8c5d5617f696
boundary condition: true
name: ND5
initial amount: NaN
constant: false
type: Species
is: P03915
is encoded by: hsa:4540
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM ksi deg24 l
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
name: keratan sulfate I, degradation product 24
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
constant: false
type: Species

metaR C181CPT1
is described by: ECO:0000269
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
product: MODEL1310110039#
fast: false

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
name: cholesterol precursor intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
product: MODEL1310110039#
is: SBO:0000185

metaR RE1709N
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
name: RE1709
reactant: MODEL1310110039#

metaR FAOXC164C143m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM leuktrF4 c
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB06465
type: Species
is: CHEBI:27491
initial concentration: 1.0
initial amount: NaN
name: leukotriene F4

metaR HISCAT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_cccf0865_6ba8_42ac_9d9e_f319f8683d65
is: Q9Y227
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: ENTPD4
constant: false
is encoded by: hsa:9583
has only substance units: false
is: SBO:0000252

metaM succ m
name: Succinate
is: C00042
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
is: HMDB00254
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:30031
has only substance units: false
constant: false

metaR C181CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false

metaR NDPK1
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
is described by: ECO:0000134
reactant: MODEL1310110039#
name: nucleoside-diphosphate kinase (ATP:GDP)
type: Reaction
modifier: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_68f0683b_9b48_43c7_a75a_48c40ae947bf
is: Q7Z3X3
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:2799
has only substance units: false
name: GNS
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR C120CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_82c509a0_15f2_4cbb_bdf0_5b10742de14e
is: F5H123
has only substance units: false
name: DYLX2
constant: false
is encoded by: hsa:9856
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM malt e
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: CHEBI:17306
has only substance units: false
initial amount: NaN
name: Maltose
is: SBO:0000247
constant: false
is: HMDB00163
boundary condition: false
type: Species
initial concentration: 1.0
is: C00208

metaM ppi m
has only substance units: false
boundary condition: false
name: Diphosphate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
type: Species
is: C00013
initial concentration: 1.0
is: CHEBI:33019
constant: false

metaM gdpmann c
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: GDP-alpha-D-mannose(2-)
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: HMDB01163

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_d7712a9f_2513_4584_91d2_a0602e0bbaf2
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: Q16698
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1666
name: DECR1

http://identifiers.org/biomodels.db/MODEL1310110039#_6110a0f3_7317_4727_9310_8af4fec10abd
is: Q9UG56
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: PISD
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23761

http://identifiers.org/biomodels.db/MODEL1310110039#_f3b70582_dd91_47ae_a8d3_8a76841f7586
is: P17707
type: Species
has only substance units: false
is encoded by: hsa:262
is: SBO:0000252
initial amount: NaN
constant: false
name: AMD1
initial concentration: NaN
boundary condition: true

metaR ACALDt
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110039#_f23d1e6d_cfc8_411c_8f20_1a7a9d398009
name: _AI824319_1_r
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:AI824319
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR NDPK2
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
type: Reaction

metaM ppi n
is: CHEBI:33019
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00250
name: diphosphate(3-)
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_2d517d3d_8f8c_4dca_9d54_7e796ad26751
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q9UI40
type: Species
name: SLC24A2
initial concentration: NaN
constant: false
is encoded by: hsa:25769

http://identifiers.org/biomodels.db/MODEL1310110039#_f6e9ebe2_1ff8_4d6f_907b_36d7279e5792
initial concentration: NaN
is: SBO:0000252
name: UGP2
has only substance units: false
initial amount: NaN
is encoded by: hsa:7360
is: Q16851
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_27037dd2_d373_4c20_ad6c_e2f015128f37
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ATP5C1
initial concentration: NaN
is: Q6I9V2
is encoded by: hsa:509
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_5fc8b549_814e_41f6_88cc_49188cdea9d2
is: P34896
has only substance units: false
initial concentration: NaN
name: SHMT1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6470

http://identifiers.org/biomodels.db/MODEL1310110039#_18d906d0_aa94_4551_8aff_8a9f3338a3b0
boundary condition: true
constant: false
initial amount: NaN
name: NT5C1B
is encoded by: hsa:93034
is: B3KUK6
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR HOXG
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
name: Heme oxygenase 1
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
reversible: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.14.99.3
kinetic law: MODEL1310110039#
is: SBO:0000176

metaR EHGLAT2m
reversible: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
is: SBO:0000176
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction

metaM leuktrF4 e
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
is: SBO:0000247
is: HMDB06465
type: Species
is: CHEBI:27491
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: leukotriene F4
constant: false

metaM HC02175 e
constant: false
initial amount: NaN
boundary condition: false
name: caprate
is: SBO:0000247
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
initial concentration: 1.0
is: CHEBI:27689
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_0caa409e_88c1_4135_89f1_7ec1de230a8e
is encoded by: hsa:2588
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P34059
name: GALNS
constant: false
initial amount: NaN
has only substance units: false

metaR r0287
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_53d16b10_3194_405e_8fc5_68751a3bc904
name: COX7A2L
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q6FGA0
constant: false
is encoded by: hsa:9167
boundary condition: true
initial amount: NaN
type: Species

metaM strdnccoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: SBO:0000247
name: stearidonyl coenzyme A
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06519
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205473
is: C16163
has only substance units: false
constant: false

metaR NDPK3
is described by: ECO:0000269
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP)
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false

metaR SCP22x
reversible: true
name: Sterol carrier protein 2
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185

metaM hdca c
initial concentration: 1.0
is: CHEBI:7896
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00220
name: palmitate
type: Species
has only substance units: false
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaR NDP7g
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus
kinetic law: MODEL1310110039#

metaR LNLNCACPT2
modifier: MODEL1310110039#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
product: MODEL1310110039#
is: SBO:0000176
name: carnitine transferase
reactant: MODEL1310110039#

metaR EX CE4724 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: apelin (1-12) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_22db0c31_fe09_4dce_96c3_115a1099ce3e
constant: false
is: P08842
is encoded by: hsa:412
name: STS
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR HSPASEly
name: heparan sulfate proteoglycan protease, lysosome (endosome)
is: SBO:0000176
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110039#

metaM ppi x
constant: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
is: SBO:0000247
has only substance units: false
is: CHEBI:33019
boundary condition: false
initial concentration: 1.0
type: Species
name: Diphosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_49d2b844_923d_4adb_934a_dd393f0f5bd4
is encoded by: hsa:8503
boundary condition: true
type: Species
initial amount: NaN
name: PIK3CD:PIK3R3
initial concentration: NaN
has part: Q92569
is encoded by: hsa:5293
has only substance units: false
has part: A7E2E0
is: SBO:0000297
constant: false

metaR r1669
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true

metaR FACOAL226
is: SBO:0000176
reversible: true
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is described by: ECO:0000000
type: Reaction
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_dff787d2_17fc_4be4_b0ad_75c5f674c0c7
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6309
initial amount: NaN
name: SC5DL
constant: false
has only substance units: false
is: Q6GTM5

metaM leuktrA4 c
initial concentration: 1.0
name: leukotriene A4(1-)
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
type: Species
is: CHEBI:57463
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR ABUTt2r
is: SBO:0000185
product: MODEL1310110039#
reactant: MODEL1310110039#
name: 4-aminobutyrate reversible transport in via proton symport
kinetic law: MODEL1310110039#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110039#_0d4b86dc_2bb1_444e_aec8_d4baf94e2cdf
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O15466
name: ST8SIA5
constant: false
type: Species
is encoded by: hsa:29906
initial amount: NaN
boundary condition: true

metaR LNLNCACPT1
type: Reaction
modifier: MODEL1310110039#
name: carnitine O-palmitoyltransferase
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110039#
is described by: ECO:0000269
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_795aa8f0_a06d_474b_bcd5_75d945bfc950
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: COX8A
is: Q53XN1
initial concentration: NaN
constant: false
is encoded by: hsa:1351
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_8e9c18e3_8360_46d0_8fb6_48c36d379352
is: SBO:0000252
initial amount: NaN
name: XDH
initial concentration: NaN
type: Species
is encoded by: hsa:7498
boundary condition: true
is: P47989
constant: false
has only substance units: false

metaR C180CRNt
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
name: C180 transport into the mitochondria
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV

metaM dad 2 c
boundary condition: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
is: CHEBI:17256
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00101
name: 2-deoxyadenosine
is: SBO:0000247

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_ebe2b07f_03f5_4271_ab5e_ee2d21f29739
initial concentration: NaN
is encoded by: hsa:7378
is: Q16831
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: UPP1
constant: false
type: Species

metaR FAOXC164C143x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6a3e0e32_19a7_4ce9_a772_503a539de7be
initial amount: NaN
name: _AI971036_1_c
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI971036
constant: false
initial concentration: NaN
boundary condition: true

metaM co2 c
boundary condition: false
is: HMDB01967
type: Species
notes: FORMULA: CO2 CHARGE: 0
is: C00011
has only substance units: false
is: CHEBI:3313
initial concentration: 1.0
name: CO2
constant: false
is: SBO:0000247
initial amount: NaN

metaM cmp c
boundary condition: false
is: CHEBI:60377
type: Species
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
initial concentration: 1.0
name: CMP
is: C00055
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_2ceaf984_4324_4ec1_affc_dc3066a2ef9e
is encoded by: hsa:5331
is: G5E960
type: Species
name: PLCB3
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM dcamp c
is: CHEBI:57567
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
has only substance units: false
initial amount: NaN
constant: false
name: N6-(1,2-Dicarboxyethyl)-AMP
is: C03794
is: HMDB00536

metaR r1668
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GTHPm
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
product: MODEL1310110039#
name: glutathione peroxidase, mitochondria
is: SBO:0000176
is described by: ECO:0000269

metaM 3ivcrn e
constant: false
name: 3-hydroxy-isovaleryl carnitine
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H23NO5 CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB12930
initial concentration: 1.0

metaM dtmp e
boundary condition: false
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:26999
name: dTMP(2-)
initial concentration: 1.0
is: SBO:0000247
is: HMDB01227

metaR CH25H
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110039#
name: cholesterol 25-hydroxylase
reactant: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.14.99.38

metaR C3DCe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR r2419
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
type: Reaction

metaR HSD3A2r
reactant: MODEL1310110039#
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.225
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR RE1709C
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
name: RE1709
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reactant: MODEL1310110039#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM ksi deg20 l
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
name: keratan sulfate I, degradation product 20
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0708e2a6_adab_4987_a153_8284bd271704
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:5151
has only substance units: false
initial concentration: NaN
is: H0YMZ7
initial amount: NaN
boundary condition: true
name: PDE8A

metaR FACOAL224
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false

metaM ksi pre36 g
is: SBO:0000247
constant: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 36
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28067
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_f746cb66_2867_4da9_abf6_8470b0bcb4d1
is: E9PCP2
name: CPT1B
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1375
type: Species
is: SBO:0000252
initial amount: NaN

metaR r1667
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110039#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
reversible: true

metaR ICDHyrm
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110039#
is: SBO:0000176

metaM leuktrA4 e
constant: false
is: SBO:0000247
is: HMDB01337
is: CHEBI:57463
initial concentration: 1.0
name: leukotriene A4(1-)
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
type: Species

metaR AMETt2m
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
name: S-Adenosyl-L-methionine reversible transport, mitochondrial

metaR RE0688E
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
name: RE0688
is described by: ECO:0000000

metaM s2l2n2m2masn e
constant: false
initial amount: NaN
name: de-Fuc form of PA6
is: C00255
is: HMDB00244
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: CHEBI:3554
has only substance units: false
is: SBO:0000247
type: Species

metaR FAOXC61m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_871c1138_2061_44e7_93f1_2ebb8775b3d6
name: _M68895_1_c
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:M68895
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_d54c985d_3f8d_48de_a48b_2eb80e644f84
initial concentration: NaN
initial amount: NaN
constant: false
is: E5KS60
is encoded by: hsa:8803
boundary condition: true
name: SUCLA2
has only substance units: false
type: Species
is: SBO:0000252

metaR PRO Dtde
reactant: MODEL1310110039#
name: D-proline transport, extracellular
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_6222e7fd_acfd_4c60_9a25_1e797c0c789a
name: SLC38A4
is encoded by: hsa:55089
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q969I6

http://identifiers.org/biomodels.db/MODEL1310110039#_1ab45f29_7285_4492_97d3_ca56dcfd6866
initial concentration: NaN
has only substance units: false
type: Species
is: P31040
initial amount: NaN
name: SDHA
is: SBO:0000252
constant: false
is encoded by: hsa:6389
boundary condition: true

metaR ILEPHELAT2tc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM dhlpro m
initial amount: NaN
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16194
type: Species
initial concentration: 1.0
name: Dihydrolipolprotein
is: SBO:0000247

metaM dad 2 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: 2-deoxyadenosine
type: Species
has only substance units: false
is: HMDB00101
constant: false
is: CHEBI:17256
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM cmp e
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00095
is: CHEBI:60377
name: CMP(2-)
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaM co2 e
is: CHEBI:16526
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: C00011
name: CO2
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0130
modifier: MODEL1310110039#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

metaM 3ivcrn c
has only substance units: false
notes: FORMULA: C12H23NO5 CHARGE: 0
constant: false
initial amount: NaN
is: HMDB06870
boundary condition: false
type: Species
is: C05998
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
name: 3-hydroxy-isovaleryl carnitine

http://identifiers.org/biomodels.db/MODEL1310110039#_ee3b87a9_24ca_44a5_887a_9120fae32f1f
initial amount: NaN
initial concentration: NaN
name: NAE1
is encoded by: hsa:8883
type: Species
is: A8MU28
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r1666
reversible: true
is: SBO:0000185
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_3872863c_3f3e_4ebf_b60d_cd31ba4af719
type: Species
is: A3KLL5
is encoded by: hsa:481
name: ATP1B1
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_1a693b74_f3d0_4e2f_8d93_c76851826539
type: Species
has only substance units: false
name: PLA2G5
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: P39877
is encoded by: hsa:5322
boundary condition: true

metaR FUMm
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase, mitochondrial
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction

metaR ELAIDCPT2
modifier: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110039#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_15dd525f_8ffe_4d40_8bf7_da92f7cc8a9d
is: Q96GD0
has only substance units: false
is encoded by: hsa:57026
initial amount: NaN
initial concentration: NaN
type: Species
name: PDXP
constant: false
boundary condition: true
is: SBO:0000252

metaM CE5867 e
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: N-acetyl-seryl-aspartyl-lysyl-proline
initial concentration: 1.0
boundary condition: false
is: CHEBI:27485
constant: false
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
type: Species
is: HMDB02710

metaR r1665
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
type: Reaction
reversible: true
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110039#

metaR TTDCRNt
product: MODEL1310110039#
reactant: MODEL1310110039#
name: transport into the mitochondria (carnitine)
fast: false
reversible: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR RE1518M
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
is described by: ECO:0000000
name: RE1518
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_a4b36fb6_a554_49d5_bbc2_3c486b7dd0ff
type: Species
boundary condition: true
name: HSD17B10
is: Q99714
is encoded by: hsa:3028
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

metaM cytd c
name: Cytidine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
is: HMDB00089
type: Species
is: C00475
constant: false
is: CHEBI:17562

http://identifiers.org/biomodels.db/MODEL1310110039#_f4e83d60_0f3b_47d9_bb52_c1835bc08dd1
is: SBO:0000297
name: ACAA1:HSD17B4:ACOX1
is encoded by: hsa:3295
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
has part: E9PB82

http://identifiers.org/biomodels.db/MODEL1310110039#_608457a3_31a8_4e7b_9ca0_46eb0ea09d86
is encoded by: hsa:498
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: ATP5A1
is: A8K092
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ad29d4a4_c217_410c_8fea_ff14a0bf6664
is: Q02252
constant: false
has only substance units: false
is: SBO:0000252
name: ALDH6A1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4329

metaM c81crn c
is: SBO:0000247
name: octenoyl carnitine
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB13324
has only substance units: false
notes: FORMULA: C15H27NO4 CHARGE: 0

metaM paf hs e
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:36707
initial concentration: 1.0
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN
boundary condition: false

metaM asp D e
type: Species
name: D-aspartate(1-)
is: HMDB06483
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:29990
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
initial concentration: 1.0
has only substance units: false

metaR PHCHGSm
reversible: true
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
is described by: ECO:0000000

metaM 5htrp c
initial concentration: 1.0
boundary condition: false
name: 5-hydroxy-L-tryptophan
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: HMDB00472
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:17780
constant: false
has only substance units: false

metaR ELAIDCPT1
reactant: MODEL1310110039#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110039#
is described by: ECO:0000269

metaR r1487
kinetic law: MODEL1310110039#
fast: false
type: Reaction
name: EC:6.2.1.3
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR r1664
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR FK
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
name: Fucokinase
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.52

metaM cmp g
is: CHEBI:60377
is: SBO:0000247
type: Species
is: HMDB00095
has only substance units: false
initial amount: NaN
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
boundary condition: false
constant: false

metaR ALASERNaEx
name: L-alanine/L-serine Na-dependent exchange (Ala-L in)
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false

metaR DHCRD1
product: MODEL1310110039#
name: dihydroceramide desaturase
fast: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176

metaM adpac x
name: adipic acid
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H8O4 CHARGE: -2
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB00448

metaM cs e deg2 l
is: HMDB01354
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57455
boundary condition: false
constant: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial concentration: 1.0
is: SBO:0000247

metaR SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
name: SPMTDe
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110039#_da5fb8c0_9016_4d8a_acc6_37931b241a47
boundary condition: true
has only substance units: false
constant: false
type: Species
name: DHFR
is: SBO:0000252
is encoded by: hsa:1719
initial amount: NaN
initial concentration: NaN
is: P00374

http://identifiers.org/biomodels.db/MODEL1310110039#_5b9dbaa5_3c22_49be_a482_592e48e566c8
boundary condition: true
name: ALG2
is: Q9H553
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:85365
constant: false
is: SBO:0000252

metaM CE5119 m
is: CHEBI:57923
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119

metaR r2142
type: Reaction
product: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_abcf92b2_de7d_40eb_8df8_f728adfb597c
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9UHK6
constant: false
name: AMACR
has only substance units: false
is encoded by: hsa:23600
initial amount: NaN
boundary condition: true

metaM asp D c
is: CHEBI:29990
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB06483
initial concentration: 1.0
name: D-aspartate(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b5bb3259_7a6a_492e_a810_801ebb4956b9
initial amount: NaN
name: LSS
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: E9PEI9
type: Species
initial concentration: NaN
is encoded by: hsa:4047

metaR UMPK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110039#
type: Reaction
name: UMP kinase (CTP),nuclear
modifier: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_7814efd0_e92f_4f41_b0ab_2ab2e1d70029
is encoded by: hsa:124454
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q5JPH6
boundary condition: true
name: EARS2
initial amount: NaN
constant: false

metaM c12dc c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00623
boundary condition: false
notes: FORMULA: C19H34NO6 CHARGE: -1
initial amount: NaN
name: dodecanedioyl carnitine
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_edc64c47_eafe_4c42_9468_ed135446946d
is: Q9UBM7
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DHCR7
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1717
constant: false

metaR EX c4crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_54faab70_8c89_469f_b9ab_bc3228ac4b61
name: ENO3
boundary condition: true
is encoded by: hsa:2027
type: Species
initial concentration: NaN
is: SBO:0000252
is: D3DTL2
initial amount: NaN
constant: false
has only substance units: false

metaM c81crn e
notes: FORMULA: C15H27NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
constant: false
name: octenoyl carnitine
initial concentration: 1.0
boundary condition: false
is: HMDB13324
type: Species
is: SBO:0000247

metaR r1662
modifier: MODEL1310110039#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR G3PD1
fast: false
is: SBO:0000176
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: glycerol-3-phosphate dehydrogenase (NAD)
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.8
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
type: Reaction

metaR r2141
reactant: MODEL1310110039#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_a9710440_2ac4_4a0b_89ac_6f755f5993d9
initial amount: NaN
has only substance units: false
is encoded by: hsa:1582
boundary condition: true
name: CYP8B1
is: Q9UNU6
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR S6TASE11ly
reversible: true
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_bf9af31f_d63c_4193_b09e_a9072476dcee
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: LTA4H
is encoded by: hsa:4048
is: SBO:0000252
initial amount: NaN
is: P09960
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_c2cb201c_a6b5_47a0_a36d_f1a2b2d86e50
is encoded by: hsa:5092
initial concentration: NaN
constant: false
name: PCBD1
initial amount: NaN
is: P61457
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR RNDR4
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000254
product: MODEL1310110039#
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (UDP)
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM cs a deg1 l
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
is: CHEBI:57455
boundary condition: false
type: Species
is: HMDB01354
initial concentration: 1.0

metaM m5masnC g
is: SBO:0000247
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: HMDB01313
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:58469
initial concentration: 1.0
notes: FORMULA: C52H87N2O40X CHARGE: 0

metaR C80CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR PI4P3K
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.153
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
fast: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.154

metaR DMATTx
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
product: MODEL1310110039#
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.1
name: dimethylallyltranstransferase

metaR DOLP Uter
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: dolichol phosphate flippase (uterus)

metaR RE0577C
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
name: RE0577
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: true
kinetic law: MODEL1310110039#

metaM spc hs e
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a26fa99f_29e5_4aa4_9074_83faa2117308
has only substance units: false
is encoded by: hsa:514
is encoded by: hsa:513
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
boundary condition: false
name: (R)-carnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00062
type: Species

metaR EICOSTETt
type: Reaction
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110039#
name: fatty acid transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_19a53328_51d9_4183_bf1a_15a78ecd1997
name: GPX5
boundary condition: true
type: Species
initial concentration: NaN
is: O75715
has only substance units: false
is encoded by: hsa:2880
constant: false
is: SBO:0000252
initial amount: NaN

metaR BHBt
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
kinetic law: MODEL1310110039#
name: (R)-3-Hydroxybutanoate transport via H+ symport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_e2616830_1cc7_4916_9688_7e05c7975c87
type: Species
has only substance units: false
is encoded by: hsa:92745
is: Q8WUX1
name: SLC38A5
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM cmp n
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:60377
is: HMDB00095
name: CMP(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f2e232c5_c31a_48e3_9fd9_7a4b18701a89
name: TRNT1
is encoded by: hsa:51095
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q96Q11

metaM dpcoa c
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57328
name: Dephospho-CoA
is: C00882
is: HMDB01373
type: Species

metaR RNDR3
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (CDP)
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176

metaR SPHS1Ptr
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ

metaR RNDR2
reversible: false
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000254
kinetic law: MODEL1310110039#
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (GDP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM hs deg9 l
initial amount: NaN
name: heparan sulfate, degradation product 9
initial concentration: 1.0
is: CHEBI:27491
is: HMDB06465
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
constant: false

metaM spc hs c
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: sphingosylphosphorylcholine
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5311445
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

metaR DOPASULT
fast: false
reactant: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110039#
name: Dopamine Sulfotransferase
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000269

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaM f26bp c
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58579
initial amount: NaN
is: HMDB01047
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
type: Species
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
initial concentration: 1.0
is: SBO:0000247

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_7dcb80bd_9043_42f9_8656_c73b055a3b61
boundary condition: true
is encoded by: hsa:81031
name: SLC2A10
is: O95528
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM dttp n
type: Species
initial concentration: 1.0
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
constant: false
is: CHEBI:37568
boundary condition: false
is: C00459
is: HMDB01342
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_b579573b_0a28_432e_8f3b_00a718d4ee30
has only substance units: false
is: Q13825
type: Species
is encoded by: hsa:549
boundary condition: true
name: AUH
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaM dc2coa m
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
has only substance units: false
is: CHEBI:61406
type: Species

metaR CAATPS
reversible: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
name: Ca ATPase
is described by: ECO:0000269
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
is version of: http://identifiers.org/ec-code/3.6.3.8
type: Reaction
modifier: MODEL1310110039#

metaM Tn antigen g
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: Tn antigen
type: Species
initial concentration: 1.0
constant: false
is: C04383

metaR r0698
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reactant: MODEL1310110039#
type: Reaction
reversible: true
modifier: MODEL1310110039#
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.2.27
kinetic law: MODEL1310110039#

metaR r0093
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.3
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176

metaR EX andrstrn LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Androsterone exchange
type: Reaction

metaR S6T17g
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR PPBNGS
is version of: http://identifiers.org/ec-code/4.2.1.24
kinetic law: MODEL1310110039#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110039#
name: porphobilinogen synthase
product: MODEL1310110039#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_4aa7855c_6c68_4df3_83da_8110a3efc9ef
initial amount: NaN
has only substance units: false
name: DPM2
is encoded by: hsa:8818
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: O94777

metaM psyl e
is: http://identifiers.org/pubchem.compound/94244
has only substance units: false
boundary condition: false
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: psyllium
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_500fc5c2_c7b4_4cde_aad4_1cdaaaad4fb9
has only substance units: false
type: Species
initial concentration: NaN
is: A6NED0
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2954
boundary condition: true
name: GSTZ1

metaM cmp m
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
name: CMP(2-)
is: CHEBI:60377
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00095

metaM co2 m
initial concentration: 1.0
name: CO2
is: HMDB01967
constant: false
has only substance units: false
is: C00011
type: Species
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:16526

metaM methf m
has only substance units: false
is: HMDB01354
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: (6R)-5,10-methenyltetrahydrofolate
initial amount: NaN
is: SBO:0000247

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r0911
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reactant: MODEL1310110039#
type: Reaction

metaM ksi deg40 l
is: CHEBI:12936
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 40
boundary condition: false

metaR C12DCTD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaR r2125
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaR THRCYSNaEx
reversible: false
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
fast: false
product: MODEL1310110039#
name: L-cysteine/L-threonine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269

metaR r0340
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
product: MODEL1310110039#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
fast: false

metaR F6Tg
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.68
name: glycoprotein 6-alpha-L-fucosyltransferase
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
reactant: MODEL1310110039#
product: MODEL1310110039#

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110039#
type: Reaction

metaM ksii core4 e
has only substance units: false
initial amount: NaN
boundary condition: false
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
is: HMDB00211
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
is: CHEBI:17268
type: Species
constant: false

metaR 4ABUTtm
name: 4-aminobutanoate mitochondrial transport via diffusion
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#

metaR RE2649M
is described by: ECO:0000000
reversible: true
name: RE2649
is: SBO:0000176
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
fast: false

metaM pmtcoa x
is: CHEBI:57379
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
is: SBO:0000247

metaR 3MOPte
fast: false
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxopentanoate
product: MODEL1310110039#

metaM crn m
type: Species
is: CHEBI:16347
is: SBO:0000247
is: C00318
initial concentration: 1.0
name: L-Carnitine
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00062
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110039#_abf8480d_c9bf_4b3c_b33a_90600e709517
is encoded by: hsa:2687
constant: false
is: SBO:0000252
name: GGT5
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: P36269
initial concentration: NaN

metaM co2 r
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
constant: false
is: HMDB01967
type: Species
initial concentration: 1.0
is: CHEBI:16526
name: CO2
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0b7a78eb_78fa_4d77_bd13_6f672df50d32
is encoded by: hsa:51102
has only substance units: false
is: Q9BV79
type: Species
boundary condition: true
is: SBO:0000252
name: MECR
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_a5af582a_d389_49b5_8f3f_0ff3c9ce3ba5
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:126
is: SBO:0000297
has part: P00326
initial amount: NaN
type: Species
name: ADH1B:ADH1C
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8066e6be_4d30_4e68_869c_b551d3df06f1
is: Q1ET61
type: Species
name: SULT1A3
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6818
initial concentration: NaN
initial amount: NaN

metaR r2126
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110039#
product: MODEL1310110039#

metaM nformanth c
initial amount: NaN
is: HMDB04089
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C8H6NO3 CHARGE: -1 INCHI: InChI=1S/C8H7NO3/c10-5-9-7-4-2-1-3-6(7)8(11)12/h1-5H,(H,9,10)(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC01553 EHMN_ABBREVIATION: C05653
name: N-formylanthranilate
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:18410

metaM c101coa c
name: decenoylcoa
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: HMDB00651

http://identifiers.org/biomodels.db/MODEL1310110039#_9d41038c_1514_4687_bc02_e4ee0c6f48eb
has only substance units: false
constant: false
boundary condition: true
name: RDH11
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51109
is: B4DDW0

metaR r1659
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_25925a42_59e8_4733_ae8b_96bb06c6ce42
is: Q9NY28
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:26290
is: SBO:0000252
name: GALNT8

http://identifiers.org/biomodels.db/MODEL1310110039#_6992012e_9604_44b7_a1b7_94061fac3ca4
boundary condition: true
is encoded by: hsa:57282
name: SLC4A10
constant: false
initial concentration: NaN
is: B7Z1R0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM Sfglutth c
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
has only substance units: false
boundary condition: false
name: S-formylglutathionate(1-)
is: HMDB01550
type: Species
is: CHEBI:57688

metaR r2127
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_75e84953_1d9e_41a5_bec4_336242b3077d
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:6487
initial amount: NaN
boundary condition: true
is: Q5T4Y1
name: ST3GAL3
type: Species

metaR ADEt
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
modifier: MODEL1310110039#
name: adenine reversible transport, cytosol
is described by: ECO:0000269
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
type: Reaction

metaM cs c deg5 l
is: CHEBI:15936
type: Species
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C23H36O24S CHARGE: -2
is: SBO:0000247

metaR DM Ser Thr ly
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaM 2mop m
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: SBO:0000247
is: CHEBI:57700
constant: false
is: HMDB01172
boundary condition: false
name: 2-methyl-3-oxopropanoate
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_4fbaa2b8_9e34_4a08_b5ae_b43f33e2f689
boundary condition: true
is encoded by: hsa:8566
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PDXK
type: Species
is: O00764
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_75a2851b_cc73_438f_ab0b_9d30a488c880
name: SLC25A21
is encoded by: hsa:89874
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: G3V4L5
boundary condition: true
type: Species
has only substance units: false

metaM fdp c
name: D-Fructose 1,6-bisphosphate
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: HMDB01058
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3647
is: CHEBI:16905
initial concentration: 1.0
is: SBO:0000247
is: C00354

metaM dhf c
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
is: C00415
is: HMDB01056
type: Species
name: 7,8-Dihydrofolate
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM adrncrn m
initial amount: NaN
notes: FORMULA: C29H49NO4 CHARGE: 0
has only substance units: false
is: HMDB00062
constant: false
initial concentration: 1.0
is: CHEBI:16347
boundary condition: false
is: SBO:0000247
name: Adrenyl carnitine
type: Species
is: C00318

metaM HC01115 c
is: CHEBI:29025
name: NeuNGc
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial concentration: 1.0

metaM thp2c x
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB12130
name: 1-piperideine-6-carboxylate

metaR AG13T4g
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110039#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
fast: false

metaM 56dura c
has only substance units: false
type: Species
constant: false
is: HMDB00076
is: SBO:0000247
name: 5,6-dihydrouracil
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:15901

http://identifiers.org/biomodels.db/MODEL1310110039#_5471c3f2_96d6_4df4_9f08_6fa1e9c40a5c
boundary condition: true
is: E7EQF2
is encoded by: hsa:54677
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: CROT
constant: false
initial concentration: NaN

metaM dgcholcoa x
is: C05461
type: Species
name: Chenodeoxyglycocholoyl-CoA
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
is: SBO:0000247
is: HMDB06897
initial amount: NaN

metaR r2128
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true

metaR AMACR2p
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
is version of: http://identifiers.org/ec-code/5.1.99.4
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000304
name: alpha-methylacyl-CoA racemase (reductase)
product: MODEL1310110039#
fast: false
reversible: false
is: SBO:0000176

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
is: CHEBI:57328
is: SBO:0000247
has only substance units: false
constant: false
is: C00882
is: HMDB01373
initial concentration: 1.0
type: Species
boundary condition: false
name: Dephospho-CoA

metaR CSNAT3x
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
name: carnitine O-aceyltransferase, peroxisomal
reversible: true
type: Reaction

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM Tn antigen l
initial amount: NaN
is: SBO:0000247
type: Species
is: C04383
has only substance units: false
name: Tn antigen
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false

metaR 5MTHFt
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
fast: false
kinetic law: MODEL1310110039#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_e31e32df_a26a_462c_b92b_31ab389fd656
is: SBO:0000297
initial concentration: NaN
name: SLC7A9:SLC3A1
has part: Q07837
initial amount: NaN
is encoded by: hsa:11136
has only substance units: false
has part: P82251
constant: false
is encoded by: hsa:6519
boundary condition: true
type: Species

metaM zymst r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
initial concentration: 1.0
is: HMDB06271
is: CHEBI:18252
initial amount: NaN
is: SBO:0000247
constant: false
name: zymosterol
type: Species
boundary condition: false
has only substance units: false

metaM octdececrn c
has only substance units: false
is: HMDB06351
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
initial amount: NaN
constant: false

metaM oh1 c
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C01328
name: hydroxide ion
initial amount: NaN
is: HMDB01039
has only substance units: false
notes: FORMULA: HO CHARGE: -1

metaR PPNCL3
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110039#
name: phosphopantothenate-cysteine ligase
fast: false
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269

metaR RE3326M
reactant: MODEL1310110039#
fast: false
type: Reaction
name: RE3326
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110039#
reversible: true

metaM mthgxl c
is: HMDB01167
is: SBO:0000247
name: methylglyoxal
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
has only substance units: false
is: CHEBI:17158

http://identifiers.org/biomodels.db/MODEL1310110039#_9aafa184_2f18_4094_afdc_f8d44c65e177
initial concentration: NaN
has only substance units: false
name: SLC25A1
constant: false
initial amount: NaN
is: D9HTE9
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6576

metaM occoa c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
constant: false
is: C01944
initial amount: NaN
is: HMDB01070
has only substance units: false
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)

metaM dpcoa m
initial amount: NaN
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
has only substance units: false
constant: false
name: 3'-dephospho-CoA(2-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01373
type: Species

metaM 5adtststerone r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
type: Species
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
is: SBO:0000247

metaM gly c
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:3339
name: Glycine
is: HMDB00123
initial concentration: 1.0
initial amount: NaN
is: C00037
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c1591f11_92b7_4731_a197_0ef4f79ecc2a
boundary condition: true
type: Species
name: NME1:NME2
has part: P22392
has only substance units: false
initial concentration: NaN
has part: P15531
is: SBO:0000297
is encoded by: hsa:4831
constant: false
initial amount: NaN
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110039#_92d70f07_78eb_41a1_b849_f88678baeb00
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: ST3GAL3
type: Species
is: Q5T4W8
has only substance units: false
boundary condition: true
is encoded by: hsa:6487

metaM dttp c
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
constant: false
name: dTTP
is: CHEBI:37568
is: HMDB01342
is: C00459
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaM c12dc x
type: Species
is: C05279
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C19H34NO6 CHARGE: -1
name: dodecanedioyl carnitine
initial amount: NaN
is: HMDB11123
is: SBO:0000247
boundary condition: false

metaR r0497
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e5adede4_aca1_475d_b869_9fc9f99479c1
boundary condition: true
is encoded by: hsa:477
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P50993
type: Species
has only substance units: false
constant: false
name: ATP1A2

metaR FERO
kinetic law: MODEL1310110039#
is described by: ECO:0000134
type: Reaction
reversible: false
name: ferroxidase
is: SBO:0000176
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
modifier: MODEL1310110039#

metaM hs deg13 l
initial concentration: 1.0
name: heparan sulfate, degradation product 13
is: HMDB01352
constant: false
is: CHEBI:17180
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM dttp e
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:37568
is: HMDB01342
is: SBO:0000247
constant: false
name: dTTP(4-)
has only substance units: false

metaM hs deg1 l
constant: false
initial concentration: 1.0
is: HMDB01352
type: Species
is: CHEBI:17180
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
name: heparan sulfate, degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110039#_63109192_3e9d_4ec0_b295_89a57088ffd9
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: P35218
name: CA5A
boundary condition: true
is encoded by: hsa:763
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b3005bc9_513a_4489_a22f_396ba0d65099
is: Q9NPB1
has only substance units: false
name: NT5M
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:56953
type: Species

metaM dpcoa l
is: SBO:0000247
name: 3'-dephospho-CoA(2-)
is: HMDB01373
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57328
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
has only substance units: false

metaM dlnlcgcoa c
initial concentration: 1.0
is: CHEBI:27979
initial amount: NaN
type: Species
boundary condition: false
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_e2c48ba7_482f_4ad1_9599_ce2423499b66
boundary condition: true
is encoded by: hsa:23563
constant: false
name: CHST5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM dhf m
constant: false
is: HMDB01056
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
name: dihydrofolate(2-)
is: CHEBI:57451
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_12eae045_370d_40d4_a884_76c9901abc8d
initial concentration: NaN
is: B1AM93
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:4702
has only substance units: false
name: NDUFA8
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_bf7adcd0_39f4_4324_9d08_7438152a0245
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:80339
type: Species
boundary condition: true
is: Q9NST1
initial amount: NaN
constant: false
name: PNPLA3

http://identifiers.org/biomodels.db/MODEL1310110039#_1bfd0882_4b7f_41ac_bad8_20134efe1cfa
name: SLC12A7
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10723
type: Species
initial concentration: NaN
constant: false
is: Q9Y666

metaM methf c
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
is: CHEBI:57455
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 5,10-Methenyltetrahydrofolate
is: HMDB01354

metaR SUCCTD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM tcynt c
name: thiocyanate
boundary condition: false
initial amount: NaN
is: CHEBI:18022
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaM oh1 e
boundary condition: false
notes: FORMULA: HO CHARGE: -1
is: C01328
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01039
name: hydroxide ion
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d0deab22_a0b2_4583_89af_849068690280
is encoded by: hsa:3177
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q14542
constant: false
name: SLC29A2
type: Species
has only substance units: false

metaM s2l2n2m2m l
has only substance units: false
name: de-Fuc form of PA6 (w/o peptide linkage)
notes: FORMULA: C84H136N6O62 CHARGE: -2
type: Species
initial concentration: 1.0
is: HMDB00573
is: CHEBI:30825
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM k e
constant: false
is: CHEBI:29103
has only substance units: false
initial concentration: 1.0
is: C00238
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
initial amount: NaN
type: Species
is: HMDB00586
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_6cc5206b_d6fc_4adc_9bb3_8bc3b8df8c60
has only substance units: false
boundary condition: true
name: SLC16A10
initial concentration: NaN
is encoded by: hsa:117247
constant: false
is: Q8TF71
is: SBO:0000252
type: Species
initial amount: NaN

metaM mthgxl e
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
has only substance units: false
is: HMDB01167
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: methylglyoxal
boundary condition: false
type: Species
is: CHEBI:17158

http://identifiers.org/biomodels.db/MODEL1310110039#_4276bc3d_2c57_4884_ac93_19702c5ec921
initial concentration: NaN
name: PLA2G7
is: Q13093
type: Species
is encoded by: hsa:7941
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaM glygn4 e
is: CHEBI:4167
initial amount: NaN
boundary condition: false
is: HMDB00122
initial concentration: 1.0
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C18H31O16X CHARGE: 0

metaM pac c
is: HMDB00209
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
has only substance units: false
name: phenylacetate
boundary condition: false
is: CHEBI:18401

http://identifiers.org/biomodels.db/MODEL1310110039#_aed07d01_3e8e_4b45_aeb3_9855a3784d56
has only substance units: false
is encoded by: hsa:7296
boundary condition: true
name: TXNRD1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_25c92168_e1b3_48f7_82a0_29264c3c2e6a
is encoded by: hsa:374291
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: NDUFS7
is: SBO:0000252
is: O75251

metaR UDPDOLPT U
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
reversible: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
product: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.117
reactant: MODEL1310110039#

metaR APAT2rm
reactant: MODEL1310110039#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: true
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110039#
fast: false
is: SBO:0000176
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_fa12ca0c_eb6e_49a4_bb09_ee52cd5cd052
name: GGT5
is encoded by: hsa:2687
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P36269
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: SBO:0000247
is: CHEBI:57795
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c6a1f246_d623_4d57_9b7f_bb768acdf7d0
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: Q9P0Z9
type: Species
name: PIPOX
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51268

metaR RE0452M
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
name: RE0452
kinetic law: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:

metaM k c
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
is: CHEBI:29103
is: SBO:0000247
has only substance units: false
is: C00238
initial concentration: 1.0
constant: false
boundary condition: false
name: potassium
is: HMDB00586
initial amount: NaN

metaR NACHEXA12ly
is: SBO:0000176
reactant: MODEL1310110039#
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#

metaR r0345
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#

metaR r1980
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110039#

metaM tcynt e
is: CHEBI:18022
name: thiocyanate
is: HMDB01453
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_455ca67a_8f15_447b_8b84_c3a8af7bcf67
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PTGDS
is: P41222
initial amount: NaN
is encoded by: hsa:5730
constant: false
type: Species

metaR S6TASE10ly
is: SBO:0000176
type: Reaction
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_6ba303fd_04c3_4f0d_83ef_1a507a24dcd8
type: Species
is encoded by: hsa:3283
initial amount: NaN
is: P14060
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: HSD3B1
has only substance units: false

metaM crn e
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00318
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
type: Species
is: CHEBI:16347
initial concentration: 1.0
is: HMDB00062

metaM adrncrn c
boundary condition: false
notes: FORMULA: C29H49NO4 CHARGE: 0
type: Species
name: Adrenyl carnitine
initial amount: NaN
has only substance units: false
is: HMDB00062
is: SBO:0000247
constant: false
is: CHEBI:16347
initial concentration: 1.0
is: C00318

metaR ASNTHRNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110039#
reversible: false
type: Reaction
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
name: L-threonine/L-asparagine Na-dependent exchange (Asn-L in)
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110039#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR C10DCCACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR OCDCAtr
is described by: ECO:0000000
name: fatty acid transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is: SBO:0000185
product: MODEL1310110039#

metaR INSTt2r
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110039#
name: inositol transport in via proton symport
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_c12107ed_5c7f_4301_98b1_18bbf29d3e83
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ACP1
is: Q59EH3
is encoded by: hsa:52
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_38c84dde_d844_43ce_b033_d5f5e0750b71
type: Species
name: NME3
is: Q13232
is encoded by: hsa:4832
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaM succ c
is: C00042
constant: false
boundary condition: false
is: HMDB00254
type: Species
is: SBO:0000247
name: Succinate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
is: CHEBI:30031

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM g6p r
type: Species
is: C00092
boundary condition: false
initial concentration: 1.0
name: D-Glucose 6-phosphate
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
is: HMDB01401
is: SBO:0000247
is: CHEBI:61548

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is described by: ECO:0000304
reversible: true
is: SBO:0000176
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
fast: false
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_1d2ad165_1f26_42a7_9a13_680f7f8def54
initial concentration: NaN
is: Q7GXZ8
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4513
name: COX2
boundary condition: true
has only substance units: false
type: Species

metaM nmn c
is: C00455
is: HMDB00229
has only substance units: false
initial concentration: 1.0
is: CHEBI:14649
initial amount: NaN
name: NMN
is: SBO:0000247
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_be439bc1_deda_49df_a575_7ac4ea954640
name: GSTZ1
initial amount: NaN
boundary condition: true
is encoded by: hsa:2954
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaR PGMT
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
fast: false
name: phosphoglucomutase
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_92dcccb9_d57c_4bc2_ad0c_36d9178a722a
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI926493
initial amount: NaN
type: Species
name: _AI926493_1_c
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_9adbeaaf_0cf7_4f11_8efc_c7fb92394ce8
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10841
name: FTCD
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_d4352159_94d9_4586_92d7_c01a4757bb38
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: OGDHL
is encoded by: hsa:55753
is: Q9ULD0
is: SBO:0000252
initial amount: NaN

metaR S6TASE25ly
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110039#

metaM xan c
constant: false
type: Species
boundary condition: false
name: Xanthine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: CHEBI:17712
is: HMDB00292
is: C00385
has only substance units: false

metaM ksii core2 deg1 l
is: HMDB00868
is: CHEBI:57737
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 1
boundary condition: false
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_5bf102d0_8572_4286_ac12_db6757184488
name: SLC4A5
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57835
boundary condition: true
constant: false
initial concentration: NaN
is: Q9BY07
type: Species

metaM ppi e
is: CHEBI:33019
is: C00013
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial concentration: 1.0
name: Diphosphate
constant: false
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_946a6e9c_5ae5_4046_a7bc_d10ba10c07dc
initial amount: NaN
is: O60503
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:115
has only substance units: false
name: ADCY9

metaM co2 x
initial amount: NaN
name: carbon dioxide
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
is: CHEBI:16526
boundary condition: false
constant: false
is: HMDB01967
type: Species
is: SBO:0000247

metaR LEUt5m
reversible: true
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false

metaR CSPG Atly
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
name: chondroitin sulfate A transport, extracellular to lysosome

metaR FAOXC163C164x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR ASNCYSNaEx
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110039#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
product: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_c90ed2ce_9768_4cf6_8ce5_407fc7ebd832
name: SYNJ1
type: Species
is encoded by: hsa:8867
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: C9JFZ1

metaM gly e
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
is: CHEBI:3339
type: Species
initial amount: NaN
is: C00037
is: HMDB00123
name: Glycine
constant: false
initial concentration: 1.0

metaM gdpfuc c
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01095
initial amount: NaN
constant: false
has only substance units: false
name: GDP-L-fucose(2-)
type: Species

metaR r0281
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110039#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:

metaR BILDGLCURtr
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
kinetic law: MODEL1310110039#
name: glucuronidated compound transport
is described by: ECO:0000000

metaR CITt4 4
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000006
reactant: MODEL1310110039#
name: citrate transport via sodium symport

metaM CE5161 r
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
is: CHEBI:57923
type: Species
boundary condition: false
has only substance units: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR DOLPMT3 Ler
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.260

metaR PALFATPtc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_e8982c50_66e4_43ad_acad_e5bbe8fa1001
boundary condition: true
name: GSTZ1
is: O43708
is encoded by: hsa:2954
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_e093192e_eae6_4722_8516_7f101162bdbb
is encoded by: hsa:6489
name: ST8SIA1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q92185
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR r0097
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
reactant: MODEL1310110039#
reversible: false
fast: false
kinetic law: MODEL1310110039#
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
product: MODEL1310110039#
is: SBO:0000176

metaM ppi c
is: SBO:0000247
is: C00013
initial amount: NaN
initial concentration: 1.0
is: HMDB00250
name: Diphosphate
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3
is: CHEBI:0
boundary condition: false
type: Species
constant: false

metaR r0494
reactant: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110039#
reversible: true

metaR ALDD2y
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110039#
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000

metaR RE1530C
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
fast: false
name: RE1530
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000

metaR RE3001M
reversible: true
name: RE3001
is described by: ECO:0000000
modifier: MODEL1310110039#
fast: false
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.1.34
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_d353c636_7000_4d22_bee1_ca8fac710e8e
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2678
is: P19440
boundary condition: true
name: GGT1
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR KSII CORE4tly
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110039#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
fast: false
reversible: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_5491e832_6c47_4227_bbac_9ff97834cec1
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: NOS3
is encoded by: hsa:4846
initial concentration: NaN
is: A0S0A7

metaM sql r
initial concentration: 1.0
boundary condition: false
is: CHEBI:15440
name: squalene
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00256
initial amount: NaN
constant: false

metaR Htg
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
reversible: true
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: proton diffusion (Golgi)

metaR r1985
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
modifier: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM stcoa c
boundary condition: false
is: HMDB01114
type: Species
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57394
is: C00412
constant: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR EX c51crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaM 2mop c
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: 2-methyl-3-oxopropanoate
type: Species
is: HMDB01172
initial concentration: 1.0
has only substance units: false
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

http://identifiers.org/biomodels.db/MODEL1310110039#_233f368d_deff_43b0_b830_96a488628644
is encoded by: hsa:8790
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: FPGT
type: Species
boundary condition: true
is: O14772
constant: false
is: SBO:0000252

metaM pmtcoa c
is: CHEBI:3454
is: SBO:0000247
is: HMDB01338
type: Species
has only substance units: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_79d60585_493e_40b2_8c2c_026f8567b0f2
is: Q8N695
constant: false
has only substance units: false
type: Species
name: SLC5A8
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:160728
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_bbd9c18b_f1f7_4774_b5ee_af308689b9a5
initial concentration: NaN
is encoded by: hsa:5281
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
name: PIGF:PIGO
type: Species
has part: Q6IB04
is encoded by: hsa:84720

metaM C02528 r
is: CHEBI:36234
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
has only substance units: false
name: chenodeoxycholate
type: Species
is: SBO:0000247

metaR VACCCRNt
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
fast: false
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_3e6366c2_2f82_4f9e_9b31_35b5933b6323
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:5279
name: PIGC
boundary condition: true

metaR RDH3a
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (11-cis,NADPH)
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110039#
reversible: true

metaM tcynt m
constant: false
is: HMDB01453
is: CHEBI:18022
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
initial amount: NaN
name: thiocyanate

metaR DADA
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.4
is: SBO:0000176
reversible: false
name: Deoxyadenosine deaminase
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_08db993b_ae31_482d_bd19_151a2b44c43c
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: Q99808
type: Species
is: SBO:0000252
name: SLC29A1
is encoded by: hsa:2030
initial amount: NaN

metaR EX tdcrn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaR RE2649C
name: RE2649
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
modifier: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110039#
type: Reaction

metaR NRVNCt
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaM octdececrn m
is: HMDB06351
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)

metaM sebacid c
notes: FORMULA: C10H16O4 CHARGE: -2
is: HMDB00792
constant: false
boundary condition: false
has only substance units: false
is: C08277
initial concentration: 1.0
is: SBO:0000247
name: sebacicacid
type: Species
initial amount: NaN

metaR r1987
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110039#

metaR r2420
reactant: MODEL1310110039#
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
fast: false

metaR XOL7AONEtr
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110039#
reversible: true

metaM guln c
type: Species
is: CHEBI:13115
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: L-gulonate
boundary condition: false
is: HMDB03290
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaR PTCRTD
name: diffusion of putriscine into the endothelial cells
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110039#_7533f9a7_e196_480a_ba2b_e32a843a4da6
initial concentration: NaN
name: TXNRD2
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10587
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_62ea4171_a9f2_4a62_aff3_fe9bd69483fa
is encoded by: hsa:AF080579
constant: false
name: _AF080579_1_c
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM bamppald c
is: HMDB01106
name: beta-Aminopropion aldehyde
boundary condition: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: C05665
is: http://identifiers.org/pubchem.compound/7975
initial amount: NaN
is: SBO:0000247

metaR r0129
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176

metaR r1764
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
reversible: false

metaR CTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: CTP diffusion in nucleus
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
fast: false
type: Reaction

metaR PI45P3K
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR r1052
is: SBO:0000185
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reversible: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7ef69333_fb92_4a0a_9d95_43b97a1d5b30
is: SBO:0000252
name: AK4
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:205
has only substance units: false
initial amount: NaN

metaR MDRPD
fast: false
is: SBO:0000176
reversible: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- Based on reaction given for B. subtilis (Sekowska A and A. Danchin paper(2002) )
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_43999097_71bc_4a90_b8e0_08ced11ecd09
constant: false
name: SRM
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P19623
boundary condition: true
is encoded by: hsa:6723
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_cade3290_603a_4c82_91ce_b399c6c2e01f
is: Q8N5Z0
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:51166
boundary condition: true
initial amount: NaN
name: AADAT
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3b4c2a0f_0669_4614_ba70_5b0e5dd71ccb
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: HADHA
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3030
is: E9KL44
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_fa37a5a3_7861_4f3c_9d0d_f3247dd3516f
constant: false
is: SBO:0000252
type: Species
is: B2RAT6
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: GALT
is encoded by: hsa:2592

metaR r0909
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
type: Reaction
name: Transport reaction
fast: false
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:

metaM nrvnccoa x
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: nervonyl coenzyme A
is: C16532
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_5b2fde3c_bd14_45b7_88c8_f955c7d77d47
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: ACOX1
constant: false
is: B4DK61
initial concentration: NaN
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110039#_8f462b56_1342_41da_a6ee_9f1848b219c6
type: Species
name: _R51273_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:R51273

metaM dc2coa x
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
is: HMDB01168
name: trans-Dec-2-enoyl-CoA

metaM Rtotal3coa c
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: R total 3 Coenzyme A
is: SBO:0000247
is: HMDB01448
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
constant: false
initial amount: NaN
is: CHEBI:16189

metaR ALAASNNaEx
is: SBO:0000185
reversible: false
product: MODEL1310110039#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
name: L-alanine/L-asparagine Na-dependent exchange (Ala-L in)

metaR r1989
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110039#
fast: false

metaR FACOAL2042
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
modifier: MODEL1310110039#
name: fatty-acid--CoA ligase
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_f061e6d3_eeb9_4a29_bbb1_c80755e538ff
has only substance units: false
is encoded by: hsa:10005
name: ACOT8
boundary condition: true
is: O14734
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaR SMPD4
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
name: sphingomyelinase
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000

metaR r0276
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
type: Reaction
fast: false
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110039#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
reversible: true
kinetic law: MODEL1310110039#

metaR VITD3t2
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
product: MODEL1310110039#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
kinetic law: MODEL1310110039#
name: Vitamin D3 uptake
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_05ad88a7_140f_47a4_a012_b10e3d58c134
has only substance units: false
initial concentration: NaN
name: ALG3
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:10195

metaM 3dhguln c
constant: false
initial amount: NaN
name: 3-dehydro-L-gulonate
is: HMDB06334
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: CHEBI:57655
boundary condition: false
has only substance units: false
type: Species

metaM glyc m
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
initial amount: NaN
constant: false
has only substance units: false
is: C00116
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Glycerol
is: CHEBI:17754

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaM mi134p c
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
has only substance units: false
is: HMDB01143
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial concentration: 1.0
is: CHEBI:58414

metaR NAGA2ly
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
product: MODEL1310110039#
name: N-acetylgalactosaminidase, alpha-
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.49

metaM pyr x
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
is: CHEBI:15361
is: HMDB00243
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: C00022
is: SBO:0000247
boundary condition: false
name: pyruvate

http://identifiers.org/biomodels.db/MODEL1310110039#_a756e4a5_a1e3_4e3f_9d5c_cbf74dc64b10
initial concentration: NaN
constant: false
boundary condition: true
is: P53794
name: SLC5A3
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:6526
is: SBO:0000252

metaM ksi pre28 g
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 28
has only substance units: false
is: HMDB00175
type: Species
is: SBO:0000247
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: CHEBI:58053

metaM prgstrn e
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:17026
initial amount: NaN
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
is: HMDB01830
is: SBO:0000247
boundary condition: false
constant: false
name: progesterone

http://identifiers.org/biomodels.db/MODEL1310110039#_8a07bb23_3d55_4b41_afb2_e158311f7159
boundary condition: true
has only substance units: false
constant: false
is: P48448
initial amount: NaN
type: Species
initial concentration: NaN
name: ALDH3B2
is encoded by: hsa:222
is: SBO:0000252

metaM dolp U r
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57683
name: dolichyl phosphate(2-)
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaR NACHEXA3ly
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaR GGT6
product: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_c46a875a_fe60_42c8_9f76_10603edb46a1
boundary condition: true
type: Species
name: _H77542_1_r
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:H77542

metaM gly m
has only substance units: false
boundary condition: false
name: Glycine
is: CHEBI:15428
type: Species
constant: false
is: SBO:0000247
is: C00037
is: HMDB00123
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_cea4017c_3059_42ad_bc5e_38af75aa4606
is: O95573
type: Species
boundary condition: true
constant: false
name: ACSL3
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2181

metaR ARACHCRNt
reactant: MODEL1310110039#
type: Reaction
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: false
is: SBO:0000185
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaR SCP21x
name: Sterol carrier protein 2
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.176

metaM CE5160 r
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
initial amount: NaN
constant: false
is: CHEBI:57923
type: Species
name: 3-oxo-cis-9-octadecenoyl-CoA
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_a44a10c7_c6c1_4cfc_85e8_0b393e8d6e4c
name: HNMT
has only substance units: false
constant: false
is: P50135
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3176
initial concentration: NaN

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
name: Ferricytochrome c
constant: false
is: CHEBI:15991
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8b9ef482_1141_4965_8e34_511b560530f2
is: A8K0I1
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: DGKH
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:160851

metaR H2MTer U
is: SBO:0000176
name: H2 mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110039#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction

metaR HIVCACBP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_0b1c56dd_8a1a_4204_beff_598c9f7ceca8
has only substance units: false
name: PI4KB
is: Q9UBF8
is encoded by: hsa:5298
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR PAPtg
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
type: Reaction
name: adenosine 3',5'-bisphosphate Golgi transport

metaM decdicrn e
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H29NO4 CHARGE: 0
has only substance units: false
is: HMDB13325
name: decadienoyl carnitine
constant: false

metaR PI34P5K
fast: false
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.68
is: SBO:0000176
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
reactant: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110039#

metaM tsul c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
constant: false
is: HMDB00257
boundary condition: false
type: Species
name: thiosulfate(2-)
is: CHEBI:16094
has only substance units: false

metaR r1655
product: MODEL1310110039#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_52a56bc2_2813_41df_8ed8_3fabca41dd0c
type: Species
has only substance units: false
is: SBO:0000252
name: NME1
is encoded by: hsa:4830
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_01514b65_dc66_41fc_a2ba_573ae7a28541
is encoded by: hsa:80150
boundary condition: true
is: SBO:0000252
is: Q7L266
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ASRGL1
type: Species
constant: false

metaM hs deg2 l
constant: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
name: heparan sulfate, degradation product 2
is: CHEBI:17180
is: HMDB01352
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_39e6a645_4d46_4d01_87c1_d2feec3d2093
boundary condition: true
initial concentration: NaN
type: Species
name: NME4
has only substance units: false
is: O00746
is encoded by: hsa:4833
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1654
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true

metaM gua e
initial concentration: 1.0
constant: false
is: HMDB00132
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:16235
name: guanine
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_3af236be_1a35_41b2_bf07_12032986b83a
is: O75355
boundary condition: true
has only substance units: false
name: ENTPD3
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:956
type: Species

metaR r2133
reversible: true
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110039#

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR FAOXC164C163x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM prgstrn c
initial concentration: 1.0
constant: false
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial amount: NaN
boundary condition: false
type: Species
is: HMDB01830
has only substance units: false
is: SBO:0000247
name: progesterone
is: CHEBI:17026

metaM dlnlcgcoa r
initial amount: NaN
constant: false
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
is: C03595
type: Species
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: CHEBI:27979
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_37a8dc0f_b935_4a88_995d_97c9da0219b7
has only substance units: false
is encoded by: hsa:3033
constant: false
name: HADH
boundary condition: true
initial amount: NaN
type: Species
is: Q16836
initial concentration: NaN
is: SBO:0000252

metaM acngalgbside hs g
name: sialyl galactosylgloboside
initial concentration: 1.0
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: HMDB03406
is: CHEBI:16523
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaM decdicrn c
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB13325
notes: FORMULA: C17H29NO4 CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
name: decadienoyl carnitine

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
type: Reaction

metaR r1050
fast: false
type: Reaction
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110039#
name: Vesicular transport
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110039#

metaR r2136
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
modifier: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110039#
is: SBO:0000185

metaR GLYCK2
name: glycerate kinase
reversible: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR

metaR r0908
is described by: ECO:0000000
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_bb87d41c_4d56_4e95_b997_2015a02c8243
name: NDUFB1
boundary condition: true
constant: false
is: O75438
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4707

metaM pmtcoa m
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN
is: CHEBI:57379
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_111bfd86_34eb_4d96_ae9e_9a828be6d2ab
type: Species
name: SLC6A5
is encoded by: hsa:9152
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: Q9Y345
initial amount: NaN

metaR r1656
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_c0ed187a_607f_497f_a8a7_7bb4eb50a0d7
type: Species
is: P05091
constant: false
is encoded by: hsa:217
name: ALDH2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r1051
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185
product: MODEL1310110039#
reversible: true
name: Vesicular transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#

metaM lthstrl r
is: HMDB01170
constant: false
has only substance units: false
is: CHEBI:17168
initial concentration: 1.0
boundary condition: false
name: 5alpha-cholest-7-en-3beta-ol
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
type: Species

metaM ksii core4 g
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
is: CHEBI:57255
is: HMDB01014
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_5a66ee20_0492_4ac8_94ec_271e823c6848
is: F8W682
name: SLC4A2
is encoded by: hsa:6522
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR PACCOAL
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
name: phenylacetate-CoA ligase
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_df7b15e9_3fc9_4e05_93d0_c903419093d2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4723
is: E5KNH5
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: NDUFV1

http://identifiers.org/biomodels.db/MODEL1310110039#_28eca485_27e3_4140_8e10_e9c665a4c01f
is: SBO:0000252
is: Q9P0J0
name: NDUFA13
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:51079
initial amount: NaN

metaM gly x
type: Species
has only substance units: false
constant: false
is: HMDB00123
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
is: SBO:0000247
is: CHEBI:15428
initial amount: NaN
initial concentration: 1.0

metaR C160CPT2
reversible: false
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
name: C160 transport into the mitochondria
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_6bff04ce_444e_4942_bfd7_4c2dc59050cd
is: SBO:0000252
is: P14324
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: FDPS
is encoded by: hsa:2224
boundary condition: true
constant: false

metaR r2130
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM CE5869 e
is: CHEBI:27485
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
type: Species
name: lysyl-proline
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02710
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r1651
reversible: true
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110039#

metaR RE1517M
modifier: MODEL1310110039#
product: MODEL1310110039#
name: RE1517
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176

metaM ksi pre7 g
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 7
is: C00130
type: Species
boundary condition: false
notes: FORMULA: C115H187N8O85SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110039#_ed52cebc_c8f3_4707_9116_6fe0b633cb46
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:LOC647190
type: Species
name: _LOC647190_1_c
initial amount: NaN
initial concentration: NaN

metaM hxcoa x
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00705

http://identifiers.org/biomodels.db/MODEL1310110039#_d976399c_f446_4f7d_a099_1b8f995c4dc1
is: Q96M32
is encoded by: hsa:122481
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: AK7
initial concentration: NaN

metaR ASNtm
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
name: L-asparagine transport, mitochondrial
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_63a8ffc6_d740_4a5e_9201_82990b4704d5
is encoded by: hsa:509
initial concentration: NaN
constant: false
is: P36542
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: ATP5C1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f8bc6847_01e6_4f8e_8cd7_6287c9952c66
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:10476
type: Species
has part: P24539
has part: P18859
initial amount: NaN
is encoded by: hsa:518
initial concentration: NaN
is: SBO:0000297
constant: false
boundary condition: true
is encoded by: hsa:515
has only substance units: false
has part: O75947
is encoded by: hsa:522

metaR XYLtly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
product: MODEL1310110039#
is described by: ECO:0000000
name: Xylose efflux from lysosome
reactant: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
fast: false

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaR r1650
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
reversible: true
is: SBO:0000185
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ADCim
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
reversible: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial

metaR GTMLTe
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110039#
is: SBO:0000185
name: g-glutamyltransferase (e)
reversible: false
fast: false
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_f87e0f42_2f8c_450f_a9e6_0bf72479d70a
initial amount: NaN
is: F8WDN9
type: Species
name: PPA2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27068
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b908cda6_faf7_4773_b918_e1e7ef1c79e1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:8050
constant: false
is: O00330
name: PDHX

metaR PAIL HStn
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaM pmtcoa r
is: CHEBI:3454
is: SBO:0000247
boundary condition: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: HMDB01338
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR GALASE15ly
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
name: beta-galactosidase, lysosomal
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false

metaM glyc e
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
boundary condition: false
type: Species
is: C00116
is: SBO:0000247
name: Glycerol
constant: false
initial amount: NaN
is: CHEBI:17754
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_959257fe_ccd4_43c5_8805_c8f3e1e77166
boundary condition: true
initial amount: NaN
has only substance units: false
is: P07203
initial concentration: NaN
type: Species
name: GPX1
constant: false
is encoded by: hsa:2876
is: SBO:0000252

metaR GGH 10FTHF7GLUe
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false

metaR ESTRADIOLtr
fast: false
type: Reaction
is: SBO:0000185
name: estradiol intracellular transport
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is described by: ECO:0000000

metaM ksii core4 l
is: CHEBI:57255
type: Species
is: SBO:0000247
is: HMDB01014
has only substance units: false
initial concentration: 1.0
constant: false
name: keratan sulfate II (core 4-linked)
initial amount: NaN
boundary condition: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110039#_04ba7a6f_ddbd_4d95_91b9_9f7155b7013d
boundary condition: true
name: UAP1L1
has only substance units: false
constant: false
initial concentration: NaN
is: Q3KQV9
type: Species
is: SBO:0000252
is encoded by: hsa:91373
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR LNLNCAt
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#
reversible: true

metaR r2132
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaR r1653
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SPODMm
name: superoxide dismutase
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#

metaR S4TASE2ly
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110039#
name: N-acetylgalactosamine-4-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110039#_96a06f38_5215_4e88_8dec_327dc769b088
name: _AI348006_1_c
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI348006

metaM stcoa m
is: HMDB01114
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
type: Species
is: SBO:0000247
is: CHEBI:57394
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
initial concentration: 1.0

metaR INSTt4 2
fast: false
type: Reaction
name: inositol transport via sodium symport
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_8def8ac8_a84f_4d3b_af35_01adc48129af
name: PLA2G12A
has only substance units: false
boundary condition: true
is encoded by: hsa:81579
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q542Y6
type: Species

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR C160CPT1
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: production of Palmitoylcarnitine
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110039#
fast: false

metaM dlnlcgcoa m
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

metaM g6p c
initial concentration: 1.0
name: D-Glucose 6-phosphate
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01401
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
type: Species
is: C00092
is: CHEBI:61548

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_83f47bcb_7919_4ff6_918c_885a24a2b944
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: DDO
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8528

metaR GLCURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
name: glucuronate transport into lysososme

metaR RTOTAL3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: RTOTAL3 transport
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
type: Reaction

metaM 1pipdn2c x
name: 1-piperideine-2-carboxylate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084
is: CHEBI:16187
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR SPODMn
modifier: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: false
name: superoxide dismutase, nuclear
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR

metaR r2131
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR C102CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM 3hddcoa m
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
is: SBO:0000247
is: C05279
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
type: Species
boundary condition: false
is: HMDB11123
initial concentration: 1.0
initial amount: NaN

metaR r1652
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_d88b2b71_75fa_49c2_baba_b00b6e8f344a
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q9UBY0
constant: false
is encoded by: hsa:6549
name: SLC9A2
has only substance units: false

metaM crn x
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: L-Carnitine
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: C00318
has only substance units: false
is: CHEBI:16347
is: HMDB00062

metaR CHATn
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176
name: Choline O-acetyltransferase
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6

metaR r1648
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000185
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ADK3m
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269
name: adentylate kinase (GTP)
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction

metaR 2MB2COAc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM lneldccoa m
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
constant: false
name: linoelaidyl coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: HMDB01064
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaM docohexcoa x
initial amount: NaN
is: SBO:0000247
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
constant: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaR THP2Ctp
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110039#_9380e43d_745b_4233_b9fb_37c10218e1c7
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9NZK7
is encoded by: hsa:30814
boundary condition: true
name: PLA2G2E

http://identifiers.org/biomodels.db/MODEL1310110039#_1ea86755_75dd_4509_9d34_ec320eca28a7
initial concentration: NaN
initial amount: NaN
name: PANK4
has only substance units: false
boundary condition: true
is encoded by: hsa:55229
type: Species
is: Q9NVE7
constant: false
is: SBO:0000252

metaR FRDPtc
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
reversible: true
product: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_86cf17ab_1a3c_4918_b468_3d271d9bd064
name: TMEM91
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:641649
has only substance units: false
is: C9JZ62
type: Species
boundary condition: true

metaM gua c
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: Guanine
is: HMDB00132
boundary condition: false
is: CHEBI:16235

metaR FAOXC225m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_1101925c_ffd6_4d76_8c43_9ac86fc067ae
name: _AI620219_1_e
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AI620219
initial amount: NaN

metaM ocdcea r
constant: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
type: Species
is: CHEBI:0
initial amount: NaN
name: octadecenoate (n-C18:1)
is: SBO:0000247
boundary condition: false
is: HMDB00207
is: C00712
initial concentration: 1.0

metaM ivcoa m
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57345
is: HMDB01113
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false
type: Species
name: Isovaleryl-CoA

http://identifiers.org/biomodels.db/MODEL1310110039#_6dc7c81f_bb82_422f_8848_e1fdf26ab531
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55811
name: ADCY10
constant: false
boundary condition: true
is: F5GWS5
type: Species

metaM sebacid x
has only substance units: false
is: HMDB00792
name: sebacicacid
is: C08277
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_256273fa_cbe4_4fec_adfc_d3cd3b31a008
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC17A4
is: SBO:0000252
is: Q9Y2C5
constant: false
has only substance units: false
is encoded by: hsa:10050
boundary condition: true

metaR r1649
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_a8ebb4cc_2944_43a2_99d2_6748cd40191f
is encoded by: hsa:23007
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: PLCH1
is: Q4KWH8
type: Species

metaM cspg c l
boundary condition: false
is: HMDB02183
is: CHEBI:36005
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110039#_26d5cd5e_046b_45ba_8f3a_412b7af4e47f
is: Q8IXW6
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: DPYSL3
constant: false
boundary condition: true
is encoded by: hsa:1809
is: SBO:0000252

metaM fol c
is: HMDB00121
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: Folate
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1

metaR PRGNLONEtm
is: SBO:0000185
fast: false
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
name: pregnenolone intracellular transport
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_79b91c15_8353_4711_80b3_1372d0971fb7
is: SBO:0000252
constant: false
initial amount: NaN
is: Q6IBB3
type: Species
is encoded by: hsa:9551
name: ATP5J2
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR RE0453C
reversible: true
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110039#
name: RE0453
is: SBO:0000176
fast: false
reactant: MODEL1310110039#

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR r0377
type: Reaction
product: MODEL1310110039#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
modifier: MODEL1310110039#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110039#_5da426fe_fb4d_452b_ae53_199a9b7ad755
type: Species
is: SBO:0000252
name: ND3
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4537
is: P03897

http://identifiers.org/biomodels.db/MODEL1310110039#_698d9a13_d3c7_4160_8e11_676d91300b29
is: P04745
boundary condition: true
constant: false
is encoded by: hsa:277
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: AMY1B
has only substance units: false

metaR AG13T5g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#

metaR H2Oter
name: H2O endoplasmic reticulum transport
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_dca33fe4_a9ae_4b93_9124_208e5a0fd77e
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:55825
initial concentration: NaN
is: SBO:0000252
is: Q9BY49
name: PECR

metaM c81coa c
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: C05276
initial concentration: 1.0
has only substance units: false
type: Species
name: octenoylcoa
initial amount: NaN
boundary condition: false
is: HMDB03949
constant: false

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR DINt
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
name: deoxyinosine transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR r1646
product: MODEL1310110039#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM vacc e
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
initial concentration: 1.0
is: CHEBI:30828
boundary condition: false
name: trans-vaccenate
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM occoa x
constant: false
is: SBO:0000247
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
type: Species
is: HMDB01070
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial concentration: 1.0
is: CHEBI:57386
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0f6de653_da7c_4221_9627_b64ff94f30a5
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _AGPAT7_1_c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AGPAT7
type: Species
constant: false

metaR GLCter
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
name: glucose transport, endoplasmic reticulum
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM pcrn c
boundary condition: false
initial concentration: 1.0
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
is: HMDB00824
has only substance units: false
initial amount: NaN

metaM 3hddcoa c
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
has only substance units: false
boundary condition: false
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
initial concentration: 1.0
is: HMDB00623
is: SBO:0000247
constant: false

metaM dec47dicoa m
name: 4,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR PAPStg
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
reversible: true
is described by: ECO:0000269
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

metaM prostge1 c
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: prostaglandin E1(1-)
is: HMDB01442
constant: false
is: CHEBI:57397
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaM xol27oh r
is: CHEBI:17703
name: 26-hydroxycholesterol
initial amount: NaN
is: SBO:0000247
is: HMDB02103
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false

metaR C161CRN2t
type: Reaction
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110039#
reversible: false
is described by: ECO:0000269
product: MODEL1310110039#
reactant: MODEL1310110039#
name: C161 transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110039#_a9646fe6_25be_4ee3_9be9_a36b8f6e909b
is: SBO:0000252
initial concentration: NaN
is: P05496
is encoded by: hsa:516
name: ATP5G1
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR r1647
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CSNAT2x
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.137
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
reversible: true
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_885638ba_48bb_4617_ac0f_29dc8e5ccf4e
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ADH6
boundary condition: true
initial amount: NaN
is encoded by: hsa:130
is: P28332
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_06660941_b9e9_4a03_b18f_594a0f7938d6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:224
is: P51648
constant: false
type: Species
name: ALDH3A2

metaR r0488
is described by: ECO:0000000
reversible: true
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
fast: false

metaR G14T18g
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
is described by: ECO:0000000

metaM CE1939 e
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
initial amount: NaN
constant: false
name: spermidine monoaldehyde 1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36781

http://identifiers.org/biomodels.db/MODEL1310110039#_d57f9a69_75f6_475a_847c_b1d73785bfa0
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: Q7GXY9
name: ND2
is encoded by: hsa:4536
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_9edb9dcf_82b6_4ada_9382_c7cd07647640
has only substance units: false
is: Q8NFF5
boundary condition: true
is encoded by: hsa:80308
is: SBO:0000252
type: Species
initial concentration: NaN
name: FLAD1
constant: false
initial amount: NaN

metaM xol27oh m
is: HMDB02103
name: 26-hydroxycholesterol
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17703
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM 3octdectecoa m
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_8b9f7ae7_adef_41c8_8d66_601a5efa730a
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: CRAT
constant: false
is: SBO:0000252
is encoded by: hsa:1384
has only substance units: false

metaR RE1845C
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
reversible: true
name: RE1845
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110039#
is described by: ECO:0000000
type: Reaction

metaR r0160
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110039#

metaM HC01410 m
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: (2E)-Hexenoyl-CoA
has only substance units: false
is: CHEBI:28706
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271

metaR OCT11EFATP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM mi1p D c
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58433
is: HMDB02985
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
is: SBO:0000247
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)

metaR UAGALDP
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
name: UDP-N-acetylgalactosamine diphosphorylase
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176
type: Reaction

metaM 25aics c
initial amount: NaN
is: HMDB00797
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58443
type: Species
is: C04823
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
has only substance units: false

metaR CYTK12n
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110039#
name: cytidylate kinase (dCMP,dCTP),nuclear
product: MODEL1310110039#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_55254352_e7bc_434c_a608_3574406ffba1
name: ADH1C
boundary condition: true
is: P00326
type: Species
initial concentration: NaN
is encoded by: hsa:126
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR HSAT1ly
reversible: false
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: heparan-glucosaminide N-acetyltransferase, lysosomal

metaR PROSTGE2t
reactant: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110039#
reversible: true
type: Reaction
modifier: MODEL1310110039#
fast: false
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_cc82ed03_3134_4b66_be02_1f47694dc76c
has only substance units: false
boundary condition: true
name: SLC13A4
is: SBO:0000252
is: Q9UKG4
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:26266
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_82c7141c_30c0_4395_824e_851c65b15c45
initial concentration: NaN
is encoded by: hsa:3101
type: Species
boundary condition: true
has only substance units: false
constant: false
is: P52790
initial amount: NaN
name: HK3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_881bb460_2e35_4c33_ab35_562947f022b0
boundary condition: true
initial amount: NaN
type: Species
name: COX6B1
constant: false
is: SBO:0000252
is encoded by: hsa:1340
initial concentration: NaN
is: P14854
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_50503130_e489_4a37_9f72_5dd18ef01fa0
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P42765
constant: false
name: ACAA2
type: Species
is: SBO:0000252
is encoded by: hsa:10449

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM andrstandn r
is: CHEBI:15994
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
name: 5alpha-androstane-3,17-dione
boundary condition: false
is: HMDB00899

metaM 10fthf7glu e
is: HMDB00108
initial amount: NaN
is: CHEBI:16236
constant: false
type: Species
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C50H57N13O25 CHARGE: -8

metaR FAOXC150m
fast: false
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid (odd chain)
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ

http://identifiers.org/biomodels.db/MODEL1310110039#_0891b38e_da91_48e4_95ef_d1b6fcb6ed3f
boundary condition: true
name: ALAS2
constant: false
initial amount: NaN
is encoded by: hsa:212
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q5JZF5

http://identifiers.org/biomodels.db/MODEL1310110039#_6c39f3e1_74b4_48bb_8b45_7ff67fbf834f
name: ST3GAL1
initial amount: NaN
constant: false
is encoded by: hsa:6482
is: SBO:0000252
has only substance units: false
is: Q11201
boundary condition: true
initial concentration: NaN
type: Species

metaM dece4coa m
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
is: HMDB02145
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 4-decenoylcoa
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_cf332793_401a_45a1_89b4_eedfb47a2d25
initial amount: NaN
boundary condition: true
is encoded by: hsa:8659
is: SBO:0000252
is: P30038
constant: false
initial concentration: NaN
name: ALDH4A1
has only substance units: false
type: Species

metaM 5aop m
initial amount: NaN
is: CHEBI:17549
is: C00430
name: 5-Amino-4-oxopentanoate
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
has only substance units: false

metaM trdox c
initial concentration: 1.0
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
initial amount: NaN
is: CHEBI:18191
type: Species
is: C00343
boundary condition: false
constant: false
is: SBO:0000247

metaR C81CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_595b33cc_cfec_4990_95df_f4d3e4cfd224
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P07195
name: LDHB
is encoded by: hsa:3945
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM fol e
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
type: Species
name: Folate
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM lpam m
name: lipoamide
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
is: HMDB00962
is: CHEBI:17460

metaR LINKDEG1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#

metaM eicostetcoa m
type: Species
has only substance units: false
is: SBO:0000247
is: C16164
constant: false
name: eicosatetranoyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial amount: NaN
boundary condition: false

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM duri c
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: Deoxyuridine
is: HMDB00012
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
has only substance units: false
is: C00526
is: SBO:0000247

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM eicostet c
is: CHEBI:36033
constant: false
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
name: eicosatetranoic acid
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR HSPGtly
kinetic law: MODEL1310110039#
fast: false
name: heparan sulfate transport, extracellular to lysosome
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR LPS
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: lipase
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.1.34

metaR ILETA
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: isoleucine transaminase
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: true

metaR r0483
reactant: MODEL1310110039#
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_f101a0a4_2bfa_41c8_a14a_32fe42b78d7d
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:223
name: ALDH9A1
is: P49189
has only substance units: false
boundary condition: true
initial amount: NaN

metaR MI145PP
reversible: false
product: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.86
is: SBO:0000176

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
reversible: false
fast: false
modifier: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_0d8fd827_9c39_45d6_874f_cb5f35204899
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:4705
type: Species
name: NDUFA10
is: O95299
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM mescon m
has only substance units: false
constant: false
name: Mesaconate
is: HMDB00749
initial concentration: 1.0
is: CHEBI:36986
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: SBO:0000247
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_44a0ea31_0837_4b5d_8f11_a25744dd8608
boundary condition: true
is encoded by: hsa:79087
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9BV10
name: ALG12
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_18b8018e_06b1_4e62_8125_a25dd787263d
is: SBO:0000252
is encoded by: hsa:54187
has only substance units: false
name: NANS
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q9NR45
type: Species

metaR FAOXC161802m
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110039#
modifier: MODEL1310110039#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110039#_12e77551_347d_4e42_9215_83ab9829db0d
constant: false
is: SBO:0000252
is encoded by: hsa:9498
has only substance units: false
type: Species
name: SLC4A8
boundary condition: true
is: E7EML0
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_efd7d55b_3ccb_4365_892b_a5872f15c423
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: SLC22A2
boundary condition: true
is encoded by: hsa:6582
initial amount: NaN
type: Species

metaR OCTDECCPT2
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM subeac c
type: Species
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2
is: HMDB00893
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: suberic acid
boundary condition: false

metaR PDX5PO
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
name: pyridoxine 5'-phosphate oxidase
modifier: MODEL1310110039#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.5

metaM ribflv e
has only substance units: false
is: HMDB00244
initial amount: NaN
name: Riboflavin
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
is: C00255
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110039#_ceaf8719_3d1e_4f12_9e7b_d44f7abdb65d
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _BG035985_1_c
is encoded by: hsa:BG035985
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_be1ab419_9bea_4296_85d2_385bc337f4a4
has only substance units: false
is: Q14442
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: PIGH
boundary condition: true
is encoded by: hsa:5283

metaR r1014
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reactant: MODEL1310110039#
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
type: Reaction
fast: false

metaR C226CPT2
name: C226 transport into the mitochondria
type: Reaction
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_243891de_dad3_4ada_8646_57ef1419bd92
is: SBO:0000252
is encoded by: hsa:1716
constant: false
type: Species
name: DGUOK
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM g3pc c
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: CHEBI:16870
initial amount: NaN
type: Species
name: sn-Glycero-3-phosphocholine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00086

metaM eicostetcoa c
name: eicosatetranoyl coenzyme A
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: C16164
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1

metaM CE5117 m
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial amount: NaN
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
type: Species
is: SBO:0000247

metaR OCTDECCPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR GCALDD
reversible: false
kinetic law: MODEL1310110039#
name: Glycolaldehyde dehydrogenase
is described by: ECO:0000304
fast: false
product: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM eicostet e
is: SBO:0000247
boundary condition: false
name: eicosatetranoic acid
constant: false
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1
is: CHEBI:36033
is: HMDB02177
initial concentration: 1.0
has only substance units: false
type: Species

metaM duri e
initial concentration: 1.0
is: C00526
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
initial amount: NaN
name: Deoxyuridine
has only substance units: false
boundary condition: false
is: CHEBI:16450
type: Species
is: HMDB00012

metaR r1013
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
name: Transport reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR C226CPT1
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
name: carnitine C22:6 transferase
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000

metaR MTHFCm
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110039#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial

metaM ivcoa c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
constant: false
name: Isovaleryl-CoA
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01113

http://identifiers.org/biomodels.db/MODEL1310110039#_073042d2_4577_4a2f_81ad_3af1ebadda86
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _BC005314_1_x
constant: false
type: Species
boundary condition: true
is encoded by: hsa:BC005314

metaR RE3346C
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE3346
kinetic law: MODEL1310110039#

metaR C142CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaM hs deg10 l
initial amount: NaN
initial concentration: 1.0
is: HMDB00127
type: Species
constant: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
is: CHEBI:15748
boundary condition: false
is: SBO:0000247
has only substance units: false
name: heparan sulfate, degradation product 10

metaM ribflv c
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
is: HMDB00244
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Riboflavin
is: C00255
constant: false

metaR r0480
fast: false
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_9b2adb75_3544_444d_8127_db0ecb5d229d
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9UHV8
name: LGALS13
has only substance units: false
is encoded by: hsa:29124

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM strch2 e
notes: FORMULA: C18H32O16 CHARGE: 0
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB00122
is: CHEBI:4167
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})

metaR S6T14g
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110039#_783488dc_b263_4d5b_ad14_fdbba1cd6dda
name: MBOAT2
initial amount: NaN
is encoded by: hsa:129642
has only substance units: false
boundary condition: true
is: Q6ZWT7
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_775424cb_33cd_4ac5_a74c_dede62c4f7b9
is: Q9HAB8
constant: false
is encoded by: hsa:79717
has only substance units: false
name: PPCS
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_3a0aeab9_277e_4197_bfd7_ee7e70ee71b7
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:762
initial concentration: NaN
initial amount: NaN
is: Q6FHI7
name: CA4
has only substance units: false

metaR PSt3
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000185
name: phosphatidylserine transport

metaM acmanap c
is: SBO:0000247
initial amount: NaN
constant: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
type: Species
boundary condition: false
is: CHEBI:58557
is: HMDB01121
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
has only substance units: false
initial concentration: 1.0

metaR r1019
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
type: Reaction
name: Postulated transport reaction
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR LTD4DP
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
is: SBO:0000176
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
reversible: true
type: Reaction
name: Leukotriene D4 dipeptidase

metaM ocdececrn c
name: 11-octadecenoyl carnitine
is: SBO:0000247
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_51f1da87_1314_49a5_aa46_fc2a17f0a8b6
boundary condition: true
type: Species
is encoded by: hsa:5297
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: PI4KA
is: SBO:0000252
is: B4DYG5

http://identifiers.org/biomodels.db/MODEL1310110039#_15e9b741_5cc9_479f_ba86_3d2600c64648
initial amount: NaN
has only substance units: false
constant: false
name: CPT1B
initial concentration: NaN
is: Q53FV7
type: Species
is: SBO:0000252
is encoded by: hsa:1375
boundary condition: true

metaR BALAtmr
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110039#
name: Beta-alanine reversible mitochondrial transport (diffusion)

metaR RE0453N
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110039#
name: RE0453
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_1a334303_01a3_4d6f_a4b6_cdfcf7068f77
name: ALG8
is encoded by: hsa:79053
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaM vacc c
is: CHEBI:30828
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
constant: false
initial amount: NaN
name: trans-vaccenate
boundary condition: false
type: Species
is: C08367
initial concentration: 1.0
has only substance units: false

metaM phe L e
is: SBO:0000247
name: L-phenylalanine
boundary condition: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
initial amount: NaN
is: HMDB00159
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR LEULEULAPc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR AHEXASEly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110039#

metaM pail35p hs c
is: CHEBI:57923
initial concentration: 1.0
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
is: SBO:0000247
boundary condition: false

metaR SERASNNaEx
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
fast: false
kinetic law: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR DOLGPP Ler
reactant: MODEL1310110039#
product: MODEL1310110039#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110039#
type: Reaction

metaR r1018
fast: false
reactant: MODEL1310110039#
reversible: true
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000

metaR OCTDECE1CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_5526745d_d959_4d1d_99b4_bec1d058c71b
is encoded by: hsa:5296
boundary condition: true
has part: P42336
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
has only substance units: false
name: PIK3CA:PIK3R2
has part: O00459
constant: false
is encoded by: hsa:5290

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR MI13PP
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000176
name: inositol-1,3-bisphosphate 3-phosphatase

metaM tdcoa m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57385
constant: false
boundary condition: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: C02593
is: HMDB01521

metaR ACOX22x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.17.99.3
modifier: MODEL1310110039#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
reactant: MODEL1310110039#
fast: false
type: Reaction
name: acyl-Coenzyme A oxidase 2, branched chain

metaR PA HSter
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
is: SBO:0000185
reversible: true
name: phosphatidate scramblase
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_65ae8728_aacc_40b4_9c52_f0d7ce9fb5bd
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6553
is: Q9NSW9
name: SLC9A5
type: Species
initial concentration: NaN
is: SBO:0000252

metaR EX c3dc
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaM docohexcoa m
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa
is: SBO:0000247
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM for e
is: SBO:0000247
is: HMDB00142
boundary condition: false
is: CHEBI:15740
has only substance units: false
initial concentration: 1.0
constant: false
name: formate
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species

metaR r1017
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
kinetic law: MODEL1310110039#
fast: false
type: Reaction
product: MODEL1310110039#

metaR RETH2e
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase (11-cis), extracellular
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM gpail hs c
boundary condition: false
is: CHEBI:17049
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
initial concentration: 1.0
constant: false

metaM 5aop c
constant: false
is: HMDB01149
type: Species
name: 5-Amino-4-oxopentanoate
has only substance units: false
is: C00430
initial amount: NaN
is: CHEBI:17549
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial concentration: 1.0

metaM phe L c
has only substance units: false
name: L-phenylalanine
is: HMDB00159
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17295
constant: false
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ba5075e8_a435_4565_aee6_cf78072bf1ea
is encoded by: hsa:122622
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ADSSL1
constant: false
is: Q8N142
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_ff0a5b9a_bdb4_406f_9cdc_1bd2bdebdd6d
constant: false
is: P54819
name: AK2
initial amount: NaN
has only substance units: false
is encoded by: hsa:204
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM fol m
boundary condition: false
initial concentration: 1.0
is: CHEBI:27470
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00121
has only substance units: false
name: Folate

metaR ALCD21 L
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110039#
name: alcohol dehydrogenase (L-1,2-propanediol)
reversible: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.99.24
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_ededbf44_39e6_440d_b344_15c361508f30
name: ACAD9
is encoded by: hsa:28976
boundary condition: true
initial concentration: NaN
is: Q9H845
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_4b22c218_90bd_44c3_bcf4_87b16c191bf4
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: P46459
is encoded by: hsa:4905
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NSF

http://identifiers.org/biomodels.db/MODEL1310110039#_ac678fe9_fbdc_4440_ac14_382fc66ca022
is: Q13907
is encoded by: hsa:3422
initial concentration: NaN
is: SBO:0000252
name: IDI1
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM cspg c e
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
has only substance units: false
boundary condition: false
is: C00106
is: HMDB00300
constant: false
initial concentration: 1.0
is: CHEBI:17568
is: SBO:0000247
initial amount: NaN
type: Species

metaR UNK3
reversible: false
product: MODEL1310110039#
name: 2-keto-4-methylthiobutyrate transamination
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:
is: SBO:0000176
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction

metaM n2m2masn g
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C11530
initial amount: NaN
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
notes: FORMULA: C50H83N4O35X CHARGE: 0
constant: false
is: SBO:0000247
type: Species

metaM for c
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
is: SBO:0000247
is: HMDB00142
boundary condition: false
has only substance units: false
name: Formate
is: CHEBI:15740
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_3c30b956_df7d_4d83_b3b1_28732b39bd41
is encoded by: hsa:R06874
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: _R06874_1_r

metaM dolglcp L r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:15812
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
has only substance units: false
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog

metaM trdox m
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
is: CHEBI:18191
boundary condition: false
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
initial concentration: 1.0

metaM ocdcea c
is: SBO:0000247
is: CHEBI:0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
type: Species
name: octadecenoate (n-C18:1)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00207
is: C00712

metaR MM5ag
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110039#_7fc7f955_b975_45d1_95db_19a813decb56
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: P20132
is encoded by: hsa:10993
initial concentration: NaN
initial amount: NaN
name: SDS

metaM 4nphsf e
is: CHEBI:35422
initial concentration: 1.0
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
has only substance units: false
is: HMDB06492
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 4-Nitrophenyl sulfate

http://identifiers.org/biomodels.db/MODEL1310110039#_109ad0e4_a5ee_47ee_af61_5ebcc8521dbc
is: SBO:0000252
name: MTMR3
has only substance units: false
is encoded by: hsa:8897
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM HC02204 e
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:27624
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959

metaR HIStN1
is: SBO:0000185
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
name: Histidine transport (Na, H coupled)
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110039#_fb538af0_b58a_4867_9a67_565a66f67a70
is: Q02318
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:1593
is: SBO:0000252
initial amount: NaN
name: CYP27A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1b2b6e0d_66f1_4a87_ab42_2a2e7e031aa5
initial amount: NaN
name: SLC27A3
boundary condition: true
initial concentration: NaN
is: Q5K4L6
is encoded by: hsa:11000
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaR FUCFUCGALACGLCGALGLUSIDEtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
name: blood group intracellular transport
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR HMGCOAtm
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1e8612f2_ac87_4483_bf3e_f5817943459b
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: PIGM
has only substance units: false
is: Q9H3S5
is encoded by: hsa:93183
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8da944b3_3f34_46bf_b137_e2807c5dea8c
type: Species
name: SUOX
initial concentration: NaN
constant: false
is: P51687
is: SBO:0000252
is encoded by: hsa:6821
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_c24b3f93_c2b2_42d6_a8dd_0dd1ade9b1e4
constant: false
initial concentration: NaN
has only substance units: false
name: SLC23A2
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9962

http://identifiers.org/biomodels.db/MODEL1310110039#_f5012920_8a1f_42ab_88f8_9cdcb799950c
has only substance units: false
constant: false
name: B3GALNT1
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:8706
is: B3KTQ4
initial amount: NaN
is: SBO:0000252

metaR CYSGLYexR
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110039#

metaM pram c
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN
initial concentration: 1.0
is: HMDB01128
is: SBO:0000247
name: 5-Phospho-beta-D-ribosylamine
boundary condition: false
has only substance units: false
is: C03090
type: Species
constant: false
is: CHEBI:58681

metaM ocdcea e
is: CHEBI:0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial amount: NaN
type: Species
is: HMDB00207
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: C00712
is: SBO:0000247

metaR NADPtxu
name: NADP transporter, peroxisome
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
is: SBO:0000185

metaR FOAXC122C101x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaM 20ahchsterol m
initial concentration: 1.0
boundary condition: false
name: 20-hydroxycholesterol
type: Species
is: SBO:0000247
is: HMDB06283
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
initial amount: NaN
is: CHEBI:1296
constant: false
has only substance units: false

metaM 4nphsf c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:35422
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
type: Species
is: SBO:0000247
name: 4-Nitrophenyl sulfate
has only substance units: false
boundary condition: false
is: HMDB06492

metaM prostge2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false
constant: false
is: HMDB01220
type: Species
boundary condition: false
name: prostaglandin E2(1-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:606564

metaM ksi deg35 l
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
boundary condition: false
constant: false
type: Species
name: keratan sulfate I, degradation product 35
initial amount: NaN
initial concentration: 1.0
is: HMDB00143
is: SBO:0000247
has only substance units: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110039#_28c1cd61_5575_4397_b1cb_99335c6ff957
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: TSTA3
is: Q13630
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:7264

http://identifiers.org/biomodels.db/MODEL1310110039#_9720aa89_fe36_40ee_980d_08bb94b8a6e2
name: VNN3:VNN2:VNN1
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:55350
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaM malcoa c
name: Malonyl-CoA
is: HMDB01175
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57384
is: SBO:0000247
is: C00083

metaM HC02204 c
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: prostaglandin-b1
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false

metaR ADSL1
name: adenylosuccinate lyase
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false
is described by: ECO:0000269

metaR RE0958E
reactant: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110039#
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true

metaR FUCtly
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
fast: false
type: Reaction
product: MODEL1310110039#
name: L-fucose efflux from lysosome

http://identifiers.org/biomodels.db/MODEL1310110039#_32979874_b168_421e_aeb3_6fb92aed6672
is encoded by: hsa:4842
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: B4DG68
name: NOS1
boundary condition: true
type: Species

metaM duri n
name: 2'-deoxyuridine
initial amount: NaN
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00012
boundary condition: false
is: CHEBI:16450

metaM clpn hs c
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
name: clpn_hs[c]
type: Species
is: HMDB02704
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:21338

metaR FUCFUCGALACGLCGALGLUSIDEte
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000185

metaM dem2emgacpail prot hs r
is: CHEBI:53486
notes: FORMULA: C37H70N3O34P3FULLRCO2FULLR2CO2X CHARGE: 0
constant: false
initial amount: NaN
name: deacylated-(phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
has only substance units: false
is: HMDB02925
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR GK1
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
reversible: true
name: guanylate kinase (GMP:ATP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d67af15b_5de9_4e1d_980b_e991f95a29b0
constant: false
is encoded by: hsa:1103
type: Species
boundary condition: true
initial amount: NaN
is: P28329
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: CHAT

metaR SERGLNNaEx
is described by: ECO:0000269
reversible: false
is: SBO:0000185
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#

metaR EX CE2915 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-casomorphin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_0f5e9e22_eaf5_4e17_9b5d_5c65c1694f52
constant: false
is encoded by: hsa:4645
initial concentration: NaN
name: MYO5B
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9H6Y6
has only substance units: false
boundary condition: true

metaR ADSL2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
name: adenylosuccinate lyase
is: SBO:0000176
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
reactant: MODEL1310110039#
reversible: false

metaR CYTK9n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110039#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110039#
name: cytidylate kinase (CMP,dCTP),nuclear
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_c71c212f_3eb6_417f_b6a7_4e3c847593ca
has part: P14415
initial amount: NaN
has only substance units: false
is encoded by: hsa:482
name: ATP1A3:ATP1B2
is: SBO:0000297
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0bf1ce14_4ea0_4c7a_8e13_9d9cc708513b
boundary condition: true
name: ABAT
constant: false
type: Species
initial concentration: NaN
is: P80404
initial amount: NaN
is encoded by: hsa:18
has only substance units: false
is: SBO:0000252

metaR S6TASE2ly
product: MODEL1310110039#
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110039#
is: SBO:0000176

metaM pan4p c
initial concentration: 1.0
initial amount: NaN
is: C01134
boundary condition: false
is: HMDB01416
constant: false
is: SBO:0000247
is: CHEBI:47942
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
has only substance units: false

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.1
is version of: http://identifiers.org/ec-code/3.1.3.2
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
product: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR RE3000M
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110039#
name: RE3000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110039#
fast: false
is: SBO:0000176
reactant: MODEL1310110039#

metaM prostge2 e
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
initial amount: NaN
boundary condition: false
is: CHEBI:606564
is: SBO:0000247
name: prostaglandin E2(1-)

http://identifiers.org/biomodels.db/MODEL1310110039#_bcb1a8ad_163e_429a_92fa_d642c4319c08
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: GPX6
initial concentration: NaN
is encoded by: hsa:257202
is: P59796
type: Species
boundary condition: true

metaR C161OHc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_742eeeb2_e682_4d02_aa62_5407d829c780
name: B3GALT5
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10317

metaR MI145PK
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000269
fast: false
name: inositol-1,4,5-trisphosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.127
modifier: MODEL1310110039#
reversible: false

metaM hdd2crn m
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB06317
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
initial amount: NaN
constant: false
boundary condition: false
name: trans-Hexadec-2-enoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110039#_cabe5980_ca98_42b9_aaa6_4793cc15401a
boundary condition: true
name: ND1
is encoded by: hsa:4535
is: Q85KV6
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: SBO:0000247
initial amount: NaN
name: (3S)-3-hydroxylinoleoyl-CoA
boundary condition: false
type: Species
constant: false
is: CHEBI:30623
has only substance units: false
initial concentration: 1.0
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110039#_3fc48947_dde3_46cc_97ff_9aa953a13df1
initial amount: NaN
has only substance units: false
constant: false
name: NDUFA4L2
initial concentration: NaN
boundary condition: true
is: Q9NRX3
is encoded by: hsa:56901
is: SBO:0000252
type: Species

metaM aicar e
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
is: HMDB01517
is: CHEBI:58475
is: C04677

http://identifiers.org/biomodels.db/MODEL1310110039#_96797b52_0ab0_4fed_b6d7_9769ebd0b3d5
initial amount: NaN
constant: false
type: Species
name: ALDH7A1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: E7EPT3
is encoded by: hsa:501

metaM crn c
is: HMDB00062
is: CHEBI:16347
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00318
type: Species
name: L-Carnitine
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM occoa m
is: CHEBI:57386
initial concentration: 1.0
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247
is: HMDB01070
type: Species
has only substance units: false
is: C01944
boundary condition: false
constant: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaR FACOAL241
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0526d425_3541_4c1b_99b2_1753944d0fc2
has only substance units: false
type: Species
name: CHST4
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q8NCG5
is encoded by: hsa:10164

metaM gdpfuc g
is: HMDB01095
is: CHEBI:57984
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: GDP-L-fucose(2-)
initial concentration: 1.0
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaM dec47dicoa x
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
name: 4,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_58218882_f662_4186_a4d6_d644d6465904
is: Q02221
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1339
name: COX6A2

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaR FRDPtr
is described by: ECO:0000000
reactant: MODEL1310110039#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM pan4p e
name: Pantetheine 4'-phosphate
is: C01134
initial concentration: 1.0
has only substance units: false
is: HMDB01416
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
type: Species
initial amount: NaN

metaR ALCD21 D
reversible: false
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.99.24
is: SBO:0000176
name: alcohol dehydrogenase (D-1,2-propanediol)
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
type: Reaction
fast: false

metaM c6crn x
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
is: SBO:0000247
name: hexanoyl carnitine
initial concentration: 1.0
is: HMDB00705
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR FACOAL240
modifier: MODEL1310110039#
reversible: true
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110039#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110039#
product: MODEL1310110039#
name: fatty-acid--CoA ligase

metaR r1796
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
name: Y+LAT2 Utilized transport
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r1020
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Postulated transport reaction
fast: false
product: MODEL1310110039#

metaR FAOXC161C141x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaR NAIt
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
fast: false
name: Na+ / iodide cotransport
type: Reaction
modifier: MODEL1310110039#
is: SBO:0000185

metaM aicar c
is: C04677
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58475

metaR DCYTDn
name: deoxycytidine deaminase, nuclear
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
reactant: MODEL1310110039#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT

metaM dec24dicoa m
constant: false
boundary condition: false
is: SBO:0000247
name: 2,4-decadienoylcoa
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: HMDB01168
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_3abf436b_7227_4c65_9a92_de1a5969457c
has only substance units: false
is: P11168
name: SLC2A2
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:6514

metaM C05280 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: cis,cis-3,6-Dodecadienoyl-CoA
initial concentration: 1.0
is: CHEBI:28002
is: HMDB03952
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_72c3fa95_4fa8_4fd9_a1d2_01155fc0bbf5
initial amount: NaN
is encoded by: hsa:217
is: SBO:0000252
type: Species
boundary condition: true
name: ALDH2
initial concentration: NaN
is: P05091
has only substance units: false
constant: false

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction
modifier: MODEL1310110039#
fast: false
product: MODEL1310110039#
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.1.9
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is described by: ECO:0000000

metaM for r
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00142
type: Species
boundary condition: false
name: Formate
is: CHEBI:15740
has only substance units: false
initial amount: NaN
is: C00058

metaR TETPENT6COAtx
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: fatty acid intracellular transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaR r1641
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM 3octdectecoa x
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: 3,6,9,12-octadecatetraenoylcoa
initial amount: NaN
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355

metaR TCYNTtm
reversible: false
name: Thiocyanate transport via diffusion (mitochondrial)
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#

metaM pap c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58343
has only substance units: false
is: HMDB00061
type: Species
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)
is: SBO:0000247
boundary condition: false

metaR SEBCOAPET
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR UDPGLCAter
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
is described by: ECO:0000269
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_921a8003_b5de_4e1c_8a6c_60cb7b9f25d0
initial concentration: NaN
name: _PRO1933_1_m
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:PRO1933
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR PLA2 2e
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.1.4
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
product: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
name: phospholipase A2

metaR TETDECE1CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR r1866
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r1640
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110039#
modifier: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
fast: false
product: MODEL1310110039#

metaM n2m2nmn l
is: SBO:0000247
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
initial concentration: 1.0
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
constant: false
is: CHEBI:15361
initial amount: NaN
is: C00022
is: HMDB00243
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_c062460d_bd04_411c_b580_748d52fb96a0
name: ADCY7
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: P51828
has only substance units: false
initial concentration: NaN
is encoded by: hsa:113
initial amount: NaN

metaR NTD9
name: 5'-nucleotidase (GMP)
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR Ser Thrtg
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
name: Ser/Thr transport (from golgi to lysosome)
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_c347f26f_710a_4f39_b872_1a2b44b0d3fc
is encoded by: hsa:1583
is: SBO:0000252
constant: false
initial amount: NaN
name: CYP11A1
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: G3XAD7

metaM ser D c
name: D-serine
has only substance units: false
is: CHEBI:16523
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB03406
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_be2adcfc_be8d_4525_83f8_f9f8eb5de98d
is: O14556
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: GAPDHS
is: SBO:0000252
has only substance units: false
is encoded by: hsa:26330

metaR PROSTGE1t
fast: false
product: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
name: prostaglandin transport via bicarbonate countertransport

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b78883c1_b620_4b91_93c4_c23ce8af4a40
type: Species
is encoded by: hsa:8309
has only substance units: false
is: Q99424
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACOX2
initial amount: NaN

metaM dec24dicoa x
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 2,4-decadienoylcoa
boundary condition: false
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110039#_464a95e9_4e1b_48a6_89b6_21b66e3abf81
initial amount: NaN
boundary condition: true
type: Species
name: ACSL6
has only substance units: false
is: B2RB13
is encoded by: hsa:23305
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0157
modifier: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.2
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reversible: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110039#
is: SBO:0000176

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_957c0946_b621_4197_b964_63725b698375
type: Species
is encoded by: hsa:23517
boundary condition: true
name: SKIV2L2
is: SBO:0000252
is: Q3MHC9
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaR ALCD2yf
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000134
reversible: false
fast: false
reactant: MODEL1310110039#
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_f41cc95c_371f_44c7_900c_b27b8d1abe48
is encoded by: hsa:4128
has only substance units: false
constant: false
is: Q53YE7
initial amount: NaN
name: MAOA
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM HC01405 m
is: SBO:0000247
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
initial concentration: 1.0
constant: false
is: CHEBI:28632
boundary condition: false
has only substance units: false
initial amount: NaN
name: (S)-Hydroxyoctanoyl-CoA

metaM datp n
name: dATP
is: HMDB01532
is: SBO:0000247
has only substance units: false
constant: false
is: C00131
initial concentration: 1.0
type: Species
is: CHEBI:61404
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
boundary condition: false

metaR PPCOAOm
reactant: MODEL1310110039#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
modifier: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction

metaR S6TASE26ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_e748c61d_d61e_4bad_897f_b95aa89fcbbc
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PRDX3
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:10935
type: Species
is: P30048

http://identifiers.org/biomodels.db/MODEL1310110039#_c1f411a0_044c_4f22_9935_cc56ff8faa7b
has part: P04843
has only substance units: false
has part: P04844
is encoded by: hsa:6185
boundary condition: true
has part: Q53G02
is encoded by: hsa:1603
is: SBO:0000297
is encoded by: hsa:6184
initial concentration: NaN
constant: false
is encoded by: hsa:1650
has part: P39656
name: DAD1:DDOST:RPN1:RPN2
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_aa068a3d_00e3_4c4f_9192_c8fc26bc2d07
is encoded by: hsa:6550
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: P48764
name: SLC9A3
type: Species

metaM ser D e
is: SBO:0000247
is: CHEBI:16523
name: D-serine
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
is: HMDB03406
initial concentration: 1.0
type: Species
boundary condition: false

metaM 3hibutcoa m
is: HMDB01052
name: (S)-3-Hydroxyisobutyryl-CoA
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: CHEBI:28259

metaR RE2445E
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.15.1
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.4.17.23
reversible: true
name: RE2445
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110039#_801096ee_2d52_4048_911e_7fa8f7a9374c
constant: false
has only substance units: false
is encoded by: hsa:498
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:509
has part: P25705
initial concentration: NaN
is: SBO:0000297
has part: Q6I9V2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_d26044b2_009c_409b_a674_298915fe8b76
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR r1645
modifier: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#

metaR RE1516M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
modifier: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR r1466
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is: SBO:0000176
name: EC:2.3.1.86
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction

metaM lneldc c
name: linoelaidic acid (all trans C18:2)
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06270

metaM pap g
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:58343
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaR FADtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reversible: false
fast: false
name: FAD transporter, endoplasmic reticulum
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction

metaR C4DCCACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR FAOXC225x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM ptdcacoa m
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB06499
constant: false
initial concentration: 1.0
name: pentadecanoyl Coenzyme A
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7d3f7fc1_9373_4055_a474_598453b51f7c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA177072
type: Species
initial concentration: NaN
has only substance units: false
name: _AA177072_1_c
boundary condition: true
constant: false

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110039#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_5b21d9dc_dd12_45dc_9065_62bea9164190
is encoded by: hsa:5860
name: QDPR
initial concentration: NaN
initial amount: NaN
is: P09417
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM didp c
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:28823

metaR DNDPt16m
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
type: Reaction
reversible: false
product: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
is: SBO:0000185
name: dUDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r1644
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000185

metaR EX decdicrn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

metaM ksi pre4 g
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C101H165N7O72X CHARGE: -1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 4
constant: false
initial concentration: 1.0
boundary condition: false
is: C00130

metaM glyc R c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16659
is: HMDB00139
constant: false
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
name: D-glycerate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_2b656da3_c616_426c_a729_42f1f3d4f6ac
is encoded by: hsa:5207
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P16118
initial amount: NaN
name: PFKFB1

http://identifiers.org/biomodels.db/MODEL1310110039#_a7152eff_ddcf_4108_9de7_159c1de21566
initial concentration: NaN
is: P21399
initial amount: NaN
boundary condition: true
type: Species
name: ACO1
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:48

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b01a002e_22b2_4ad2_b711_d093c4a93b24
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: ACSS2
is: SBO:0000252
is encoded by: hsa:55902
type: Species
is: Q5QPH3
boundary condition: true

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR NTD4
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
reversible: false
is described by: ECO:0000254
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (51251.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110039#
name: 5'-nucleotidase (CMP)

metaR DIGALSIDEtg
kinetic law: MODEL1310110039#
is: SBO:0000185
name: digalside hs intracellular transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
fast: false

metaR GMPR
is: SBO:0000176
type: Reaction
name: GMP reductase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.7.1.7
kinetic law: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
product: MODEL1310110039#
reversible: false

metaR RE1531M
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: RE1531
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
fast: false
product: MODEL1310110039#

metaR r1643
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#

metaR r0153
reversible: false
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110039#
fast: false
is: SBO:0000176

metaR r1464
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
name: Active transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110039#

metaM CE5854 e
constant: false
is: HMDB02710
is: SBO:0000247
boundary condition: false
has only substance units: false
name: gama-CEHC-glucuronide
is: CHEBI:27485
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_647881f2_d815_4347_b9f9_664614649aff
has only substance units: false
is encoded by: hsa:55276
boundary condition: true
initial concentration: NaN
is: Q96G03
is: SBO:0000252
type: Species
constant: false
name: PGM2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_0591a17a_1cda_4d85_a2df_182131f6c774
constant: false
initial concentration: NaN
type: Species
name: AMPD2
is encoded by: hsa:271
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q01433
is: SBO:0000252

metaR ARACHDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110039#

metaM frdp c
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial concentration: 1.0
is: CHEBI:175763
initial amount: NaN
type: Species
constant: false
is: HMDB00961
boundary condition: false
name: Farnesyl diphosphate
is: SBO:0000247
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110039#_5f81ac90_715c_4e7e_b0c1_d6c3f4a84430
initial amount: NaN
is encoded by: hsa:2181
constant: false
is: B3KMA6
is: SBO:0000252
name: ACSL3
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR NTD7
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000176
name: 5'-nucleotidase (AMP)
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_35fdb0d4_6843_419b_b860_be9f262016b2
is encoded by: hsa:271
name: AMPD2
boundary condition: true
is: B2RB47
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaR RTOTAL2t
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
name: RTOTAL2 transport

metaR r1642
product: MODEL1310110039#
is: SBO:0000185
reversible: true
reactant: MODEL1310110039#
modifier: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM acgpail hs c
boundary condition: false
is: CHEBI:57265
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
constant: false
is: SBO:0000247
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR C2tcx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_2d050ea3_ca5e_4f8e_8755_01086c14314f
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: _AI972237_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI972237
initial concentration: NaN

metaM CE5118 m
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial concentration: 1.0
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110039#_2f3970b6_2553_4464_878a_6dca77f4b999
is: Q11203
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6487
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: ST3GAL3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7f9240be_7840_4b95_8e65_5d7121d68fa6
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:51227
initial concentration: NaN

metaR GRTTx
modifier: MODEL1310110039#
name: geranyltranstransferase
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is described by: ECO:0000134

metaR RE2814R
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: RE2814
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
fast: false

metaR UGT1A10r
reactant: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reversible: true
product: MODEL1310110039#
is described by: ECO:0000134

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_287ed5d7_5741_4e33_89c2_f73750fdd72b
initial concentration: NaN
is encoded by: hsa:81539
initial amount: NaN
name: SLC38A1
boundary condition: true
has only substance units: false
is: Q9H2H9
type: Species
constant: false
is: SBO:0000252

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
fast: false

metaM acnam c
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
boundary condition: false
is: CHEBI:35418
initial concentration: 1.0
initial amount: NaN
is: HMDB00230
name: N-acetylneuraminate
constant: false
has only substance units: false
is: SBO:0000247

metaR ADRNCRNt
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
is: SBO:0000185
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)

metaR GLUPRT
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.14
reversible: false
type: Reaction
name: glutamine phosphoribosyldiphosphate amidotransferase
is: SBO:0000176

metaM cspg e e
is: SBO:0000247
is: HMDB00300
has only substance units: false
type: Species
is: C00106
is: CHEBI:17568
initial amount: NaN
initial concentration: 1.0
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
boundary condition: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110039#_c49c7d90_a28f_43d4_bc8b_1dd499295437
name: PIP5K1B
constant: false
is encoded by: hsa:8395
boundary condition: true
is: O14986
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaM lneldc e
is: HMDB06270
name: linoelaidic acid (all trans C18:2)
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
type: Species

metaR CYTK11n
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP),nuclear
is described by: ECO:0000269
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_eae69a26_4d78_4af2_9fc0_c17cd15c0754
initial amount: NaN
type: Species
name: COX7C
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1350
is: P15954
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9907ee59_cbfc_4629_9072_a40490e24dbc
name: PI4KB
is: Q9UBF8
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:5298
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_285aae04_5386_4d53_9822_a3bddfd56212
has only substance units: false
constant: false
name: PCBD1
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5092
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_f481543d_bd24_485c_bd1d_0af94283b36f
type: Species
is encoded by: hsa:8525
initial concentration: NaN
constant: false
boundary condition: true
name: DGKZ
has only substance units: false
initial amount: NaN
is: B7Z2M9
is: SBO:0000252

metaR SERCYSNaEx
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
modifier: MODEL1310110039#
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
reversible: false

metaM leuktrC4 c
constant: false
is: CHEBI:57973
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247
initial concentration: 1.0
is: HMDB01198
has only substance units: false
name: leukotriene C4(2-)
initial amount: NaN
type: Species

metaR B3GNT51g
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
product: MODEL1310110039#
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false

metaR r1635
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dolglcp L c
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false
is: CHEBI:15812
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_71f012bf_3dc1_4b37_b420_794ec8fdb53a
boundary condition: true
type: Species
is encoded by: hsa:11227
constant: false
initial amount: NaN
has only substance units: false
is: A5PKZ1
initial concentration: NaN
name: GALNT5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_7e5df296_875d_4804_9985_3a4b0ca5a76b
is: SBO:0000252
is encoded by: hsa:5019
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: P55809
name: OXCT1

http://identifiers.org/biomodels.db/MODEL1310110039#_9c7db3ae_b357_41b1_aafb_f1c2c324439d
is: P20674
boundary condition: true
initial concentration: NaN
name: COX5A
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:9377

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_927437dc_c0b8_4077_83d6_20c853f8bee6
initial concentration: NaN
is encoded by: hsa:AA419122
has only substance units: false
constant: false
name: _AA419122_1_c
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM xtsn c
name: xanthosine
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:18107
is: HMDB00299
is: SBO:0000247
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762

metaM core2 g
constant: false
boundary condition: false
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial amount: NaN
type: Species
is: CHEBI:15876
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c9c04d8c_fc2d_4e79_8770_1a456c5c0d13
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:93034
initial amount: NaN
is: Q96P26
boundary condition: true
has only substance units: false
name: NT5C1B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_16bd9e7c_4941_4acf_9c8d_3f2404c473e4
constant: false
initial amount: NaN
is encoded by: hsa:4514
has only substance units: false
name: COX3
is: P00414
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
name: DMNONCOACRNCPT1
fast: false

metaR r1636
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false

metaR r1637
type: Reaction
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true

metaR FE3MTP1
kinetic law: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000134
fast: false
type: Reaction
name: transport of ferrous iron into blood
modifier: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_82efd8e9_49ba_4993_9ecb_08cbbe0835bf
initial amount: NaN
boundary condition: true
name: LDHB
constant: false
type: Species
has only substance units: false
is: P07195
is encoded by: hsa:3945
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_bcee4814_4f13_4656_84c5_e1c9352bd3f0
name: PIGV
is encoded by: hsa:55650
has only substance units: false
initial amount: NaN
is: Q9NUD9
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM pheacgln e
has only substance units: false
constant: false
type: Species
is: HMDB06344
initial concentration: 1.0
is: CHEBI:58310
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110039#_cf2d3850_2c20_426f_86c4_011fa0a2c096
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN
type: Species
is encoded by: hsa:9057
has only substance units: false
has part: Q92536
name: SLC3A2:SLC7A6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_78c478ee_3953_4a5a_8236_7b6ce147c0cd
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _AA576959_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:AA576959
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_9d944645_bfe9_4e7d_b342_a0e620e97439
initial amount: NaN
is encoded by: hsa:6574
has only substance units: false
boundary condition: true
name: SLC20A1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: Q8WUM9

metaR r0365
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM leuktrC4 e
is: CHEBI:57973
is: SBO:0000247
boundary condition: false
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: leukotriene C4(2-)

metaR DM T antigen g
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR LEUKTRB4t
type: Reaction
name: leukotriene B4 transport
reversible: true
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR C161CRNt
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false
is described by: ECO:0000000
modifier: MODEL1310110039#
name: C161 transport into the mitochondria
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
reactant: MODEL1310110039#

metaR NACHEX12ly
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
is: SBO:0000176
reversible: false
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR ST8SIA11
kinetic law: MODEL1310110039#
name: Beta-galactoside alpha-2,3-sialyltransferase
type: Reaction
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
reversible: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
fast: false

metaM thym c
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
name: Thymine
constant: false
is: CHEBI:17821
is: C00178
is: HMDB00262

metaM ptdcacoa c
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06499
name: pentadecanoyl Coenzyme A
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7ba22894_e78d_4de6_aecf_167e929fb61a
is: P50225
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6817
name: SULT1A1
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_bb946aa0_d7af_4011_9704_2b43add6ae56
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5296
is: O00459
name: PIK3R2

metaR DESAT18 4
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
kinetic law: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR G14T17g
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110039#

metaR FAOXC10C8x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_bb5f7013_fe38_4428_b998_b6ac9d9995ed
initial concentration: NaN
type: Species
initial amount: NaN
name: FBP1
boundary condition: true
constant: false
is encoded by: hsa:2203
is: SBO:0000252
has only substance units: false
is: Q2TU34

metaR r1638
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
fast: false
product: MODEL1310110039#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE5132 n
has only substance units: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: CHEBI:57923
initial amount: NaN

metaR r0360
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is version of: http://identifiers.org/ec-code/6.2.1.16
reversible: false
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110039#
type: Reaction

metaR ARSA
is version of: http://identifiers.org/ec-code/3.1.6.8
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
fast: false
name: Arylsulfatase A
modifier: MODEL1310110039#
is: SBO:0000176

metaR DPMVDx
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
type: Reaction
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase
reversible: false
modifier: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.33

metaM gsn c
is: C00387
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00133
constant: false
name: Guanosine
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: CHEBI:16750
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_c0522f1a_42ff_45e8_b9ff_73e0da1f4706
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: Q9NQR4
name: NIT2
is: SBO:0000252
constant: false
is encoded by: hsa:56954

metaR CORE6GTg
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110039#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
fast: false
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
type: Reaction
is described by: ECO:0000000

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR UGCG
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.80
is described by: ECO:0000000
name: Ceramide glucosyltransferase
modifier: MODEL1310110039#
type: Reaction

metaR ST8SIA12
type: Reaction
reversible: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.99.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
name: Beta-galactoside alpha-2,3-sialyltransferase

metaR C16DCe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR GALASE17ly
reversible: false
product: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR r1639
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: true

metaM CE4724 e
boundary condition: false
notes: FORMULA: C60H105N22O15S CHARGE: 3 INCHI: InChI=1/C60H102N22O15S/c1-33(2)27-40(77-50(88)37(12-6-21-69-59(64)65)74-55(93)44-15-9-24-81(44)56(94)38(13-7-22-70-60(66)67)75-48(86)35(62)17-18-46(63)84)51(89)79-42(31-83)53(91)78-41(28-34-29-68-32-72-34)52(90)73-36(11-4-5-20-61)49(87)71-30-47(85)80-23-8-14-43(80)54(92)76-39(19-26-98-3)57(95)82-25-10-16-45(82)58(96)97/h29,32-33,35-45,83H,4-28,30-31,61-62H2,1-3H3,(H2,63,84)(H,68,72)(H,71,87)(H,73,90)(H,74,93)(H,75,86)(H,76,92)(H,77,88)(H,78,91)(H,79,89)(H,96,97)(H4,64,65,69)(H4,66,67,70)/p+3/t35-,36-,37-,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1 EHMN_ABBREVIATION: CE4724
name: apelin (1-12)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: C01936
constant: false

metaM didp n
type: Species
has only substance units: false
is: SBO:0000247
name: dIDP
initial concentration: 1.0
is: CHEBI:28823
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536

http://identifiers.org/biomodels.db/MODEL1310110039#_241b63eb_bb8a_4054_a7bb_f278752307d4
name: MTHFD2L
is: Q9H903
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:441024
has only substance units: false
boundary condition: true

metaM ipdp x
name: isopentenyl diphosphate(3-)
is: CHEBI:128769
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
boundary condition: false
is: HMDB01347
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM 2dr5p c
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: HMDB01031
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)
constant: false
initial concentration: 1.0
is: CHEBI:57651
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC102C81m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_2a963a20_a605_4457_a399_a1c721f8c2fd
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2618
is: Q59HH3
name: GART

metaM 4hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 4,7,10-hexadecatrienoylcoa
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB02288
initial concentration: 1.0

metaM succoa x
is: HMDB01022
has only substance units: false
type: Species
name: Succinyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaR AG13T6g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM lald D c
has only substance units: false
boundary condition: false
name: (R)-lactaldehyde
is: HMDB06458
type: Species
is: CHEBI:17167
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: SBO:0000247

metaR GTHRDt
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110039#
reversible: true
name: Glutathione transport into mitochondria

metaR DKMPPD
fast: false
name: 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction
reversible: false
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2543672 NOTES:JLR- based on B. subtilis and K. pneumoniae reactions (not sure about the h2o and h)
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_3b315a01_9867_4656_829d_ac4485c9084f
type: Species
name: ALDOB
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P05062
is encoded by: hsa:229
boundary condition: true
constant: false
initial amount: NaN

metaM thbpt4acam c
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02281
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
type: Species
constant: false
initial amount: NaN

metaM cspg b e
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: C00106
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: CHEBI:17568
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
type: Species
is: HMDB00300

http://identifiers.org/biomodels.db/MODEL1310110039#_d532ab2d_32c9_47ab_9757_5069f2ba1c78
is: Q10472
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: GALNT1
initial amount: NaN
boundary condition: true
is encoded by: hsa:2589

metaR SEBACACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_a80678a0_275d_4b6c_9f57_ce41a6bc6a17
is: SBO:0000252
name: GALNT3
initial concentration: NaN
constant: false
is: Q14435
is encoded by: hsa:2591
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_25e97e6a_3fb7_4887_bc6a_d38bf8435ba1
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:728226
name: _728226_1_m
type: Species
initial amount: NaN

metaM dcacoa c
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
is: SBO:0000247
initial concentration: 1.0
is: HMDB06404
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaM Ser Thr l
initial amount: NaN
has only substance units: false
is: CHEBI:58190
type: Species
is: HMDB00224
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0

metaM ksii core4 pre9 g
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28067
initial amount: NaN
type: Species
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
boundary condition: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 9

http://identifiers.org/biomodels.db/MODEL1310110039#_6def8175_e667_4445_9259_9de57b8254a9
initial concentration: NaN
boundary condition: true
has part: B7Z3U6
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:483
is: SBO:0000297
is encoded by: hsa:476
name: ATP1A1:ATP1B3
has only substance units: false
has part: P54709

http://identifiers.org/biomodels.db/MODEL1310110039#_358710fd_6534_42f7_93e0_41b5cc900d1f
has only substance units: false
initial amount: NaN
name: DLD
is: SBO:0000252
type: Species
is encoded by: hsa:1738
boundary condition: true
constant: false
is: P09622
initial concentration: NaN

metaR FAOXC12C12OHm
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_16e6ce48_57a2_4dd5_ba28_1472c628188f
is: P51648
initial concentration: NaN
name: ALDH3A2
boundary condition: true
is encoded by: hsa:224
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_25e5c2ec_543b_4a4b_864a_1b23725be248
constant: false
is: SBO:0000252
is: Q6LEN5
is encoded by: hsa:1103
has only substance units: false
initial amount: NaN
name: CHAT
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_c456f4fa_6781_46ff_9386_e1476ec948b4
is: SBO:0000252
name: PDE4C
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5143
is: Q7KYS4
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_a9ccd2a7_c53e_4225_a488_6c2212c6128f
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: Q6YFQ2
is encoded by: hsa:125965
name: COX6B2
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_94e159ed_d060_48dc_9f60_8e8ce5474d7d
is encoded by: hsa:5209
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q16875
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: PFKFB3

metaM xyl D l
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:15936
boundary condition: false
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
initial amount: NaN
name: aldehydo-D-xylose

metaM creat c
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
has only substance units: false
name: creatine
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16919
is: SBO:0000247
initial amount: NaN

metaM CE2838 e
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: SBO:0000247
is: C01936
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/5041
name: maltononaose
initial amount: NaN

metaR DECDICRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_11c98052_fa1f_4144_9098_4b92a9da7cf4
type: Species
is: SBO:0000252
initial amount: NaN
is: A8K3J4
name: CA14
initial concentration: NaN
is encoded by: hsa:23632
constant: false
has only substance units: false
boundary condition: true

MODEL1310110039#
species: metaM cs a l
species: metaM xyl D c
species: metaM ksi pre23 g
species: metaM mescon m
name: ATP1A1:ATP1B1
species: metaM o2 x
species: metaM HC02121 c
species: metaM ttdca e
species: metaM hxcoa m
species: metaM HC02217 c
species: metaM gsn c
species: metaM HC01412 m
species: metaM adn m
species: metaM hpdca e
species: metaM pail34p hs c
species: metaM q10h2 e
species: metaM CE2431 m
species: metaM occoa m
species: metaM hs deg10 l
name: PIK3CB:PIK3R1
species: metaM vacc e
initial concentration: NaN
species: metaM dha e
species: metaM 10fthf6glu e
species: metaM vacccrn m
species: metaM octd11ecoa m
species: metaM so4 e
species: metaM pi r
species: metaM xol7ah2 c
species: metaM pyr c
species: metaM sgalside hs l
species: metaM dsmsterol r
species: metaM ksii core4 deg4 l
species: metaM cmp c
species: metaM co2 c
species: metaM arg L c
species: metaM accoa m
species: metaM orn e
species: metaM c4crn m
species: metaM mal L m
species: metaM anth c
stoichiometry: 14.0
species: metaM 56dthm c
species: metaM nmn c
stoichiometry: 0.005829
species: metaM HC02179 e
species: metaM idp n
species: metaM HC02203 c
species: metaM uacgam r
species: metaM 3hpcoa m
species: metaM 4h2oglt m
species: metaM prostgi2 e
species: metaM hmgcoa x
species: metaM eicostet c
species: metaM 1pyr5c m
species: metaM amp x
species: metaM h2o2 n
species: metaM acmana e
species: metaM acgam c
species: metaM dhap e
species: metaM lys L x
species: metaM chol e
stoichiometry: 6.0
species: metaM eicostetcoa m
species: metaM itp e
species: metaM hs deg7 l
species: metaM m8mpdol U r
species: metaM n2m2nmn l
species: metaM dolmanp L c
species: metaM dcyt e
species: metaM 4fumacac c
species: metaM fe3 e
species: metaM arachdcoa r
species: metaM prostgd2 r
species: metaM gm3 hs g
species: metaM pheacgln c
species: metaM gncore2 g
species: metaM pmtcrn m
species: metaM cdpdag hs m
species: metaM dcacoa m

metaM glyc R m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16659
type: Species
boundary condition: false
is: HMDB00139
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate

metaR ACGAMtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-glucosamine lysosomal efflux
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#

metaM lac L e
boundary condition: false
constant: false
is: CHEBI:16651
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00190
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species

metaM cs e deg1 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00868
has only substance units: false
is: CHEBI:57737
notes: FORMULA: C45H65N2O52S5 CHARGE: -7

metaR MHISOR
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.4.3.21
is described by: ECO:0000269
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)

http://identifiers.org/biomodels.db/MODEL1310110039#_5e6dfe9d_bcb7_4521_8eda_d8bf61322f00
name: ALG3
is encoded by: hsa:10195
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM 4mzym int1 r
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: HMDB06927
constant: false
name: 4-Methylzymosterol intermediate 1
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_60e77664_9514_4840_b1bd_161f97f3e5d9
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: P51857
initial amount: NaN
is encoded by: hsa:6718
constant: false
name: AKR1D1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_9b553ca0_19cf_492e_81a1_59cfad7c5c48
boundary condition: true
is: O95427
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:23556
type: Species
name: PIGN
constant: false
is: SBO:0000252

metaR FBP
modifier: MODEL1310110039#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
name: fructose-bisphosphatase
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.11
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP

metaM CE2916 e
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
type: Species
constant: false
name: neocasomorphin
initial concentration: 1.0
has only substance units: false
is: C01936
notes: FORMULA: C35H51N6O10 CHARGE: -1 INCHI: InChI=1/C35H52N6O10/c1-5-20(4)29(35(50)51)39-31(46)26-9-7-17-41(26)34(49)24(14-15-27(43)44)37-32(47)28(19(2)3)38-30(45)25-8-6-16-40(25)33(48)23(36)18-21-10-12-22(42)13-11-21/h10-13,19-20,23-26,28-29,42H,5-9,14-18,36H2,1-4H3,(H,37,47)(H,38,45)(H,39,46)(H,43,44)(H,50,51)/p-1/t20-,23+,24+,25+,26+,28-,29-/m0/s1 EHMN_ABBREVIATION: CE2916
is: SBO:0000247
boundary condition: false

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaR DCSPTN1CRNt
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110039#

metaM ca2 e
is: CHEBI:29108
initial concentration: 1.0
is: HMDB00464
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: calcium(2+)
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
boundary condition: false

metaR CSCPASEly
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
product: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_e5e0b7e9_d90a_44d6_9883_be2169aab145
initial amount: NaN
has only substance units: false
is encoded by: hsa:7296
is: SBO:0000252
name: TXNRD1
type: Species
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_28378cef_40db_4725_b307_ea7ffa460eba
name: B3GALT5
initial concentration: NaN
type: Species
is: Q9Y2C3
is: SBO:0000252
is encoded by: hsa:10317
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaM creat e
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
has only substance units: false
name: creatine
boundary condition: false
initial concentration: 1.0
is: CHEBI:16919
is: SBO:0000247
initial amount: NaN
type: Species

metaR DOLPGT2 Uer
modifier: MODEL1310110039#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)

metaM lac L c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
is: CHEBI:16651
type: Species
has only substance units: false
boundary condition: false
name: (S)-lactate
initial concentration: 1.0
is: HMDB00190
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9a2e01da_73a7_4193_8864_03ecbe5e4e0a
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:8310
initial amount: NaN
is: O15254
name: ACOX3

http://identifiers.org/biomodels.db/MODEL1310110039#_aa9589de_2d42_484e_8adb_d433d41f8a92
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: SLC38A3
is: Q99624
initial amount: NaN
is encoded by: hsa:10991
has only substance units: false

metaM sTn antigen g
is: HMDB01256
boundary condition: false
name: sialyl-Tn antigen
notes: FORMULA: C19H30N2O13X CHARGE: -1
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:45725

metaR ECOAH12m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_837fa07e_7ad5_44cf_941b_d82b290327fb
is: Q969K7
type: Species
name: TMEM54
is encoded by: hsa:113452
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR DM fol
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_daef8252_56cb_42d8_a1af_5cba1311f0bb
is: SBO:0000252
name: SULT1A3
type: Species
has only substance units: false
is encoded by: hsa:6818
initial amount: NaN
is: P50224
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_5f1c828f_440f_4a39_82ed_3be9ca5cc223
has only substance units: false
type: Species
is: P23677
is encoded by: hsa:3706
is: SBO:0000252
initial amount: NaN
name: ITPKA
boundary condition: true
constant: false
initial concentration: NaN

metaM Ser Thr g
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
type: Species
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58336
boundary condition: false
is: HMDB00645

metaR S6T15g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
product: MODEL1310110039#
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_e0ca0c51_e93f_44ff_b922_8178b40cd778
boundary condition: true
is encoded by: hsa:1103
constant: false
initial amount: NaN
name: CHAT
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: D3DX95

metaM CE1936 e
is: SBO:0000247
boundary condition: false
is: CHEBI:36781
name: spermine dialdehyde
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_006de5f6_7795_4d61_99bf_7b5dd17e5d27
initial amount: NaN
type: Species
name: GALK2
is encoded by: hsa:2585
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_26e36d6f_bbba_4ba7_9c25_d63c45dd4b50
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9P0J0
is encoded by: hsa:51079
name: NDUFA13

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM 5mthf e
is: C00440
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:3729
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
is: HMDB01396
boundary condition: false
constant: false
initial concentration: 1.0

metaM ksii core4 pre10 g
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:28067
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10

http://identifiers.org/biomodels.db/MODEL1310110039#_2a6b5ced_00b5_4cc5_81da_8780017ba510
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:64064
boundary condition: true
name: OXCT2
is: Q9BYC2
type: Species
is: SBO:0000252
constant: false
has only substance units: false

metaR NRPPHRSULT
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.8.2.1
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: Norepinephrine Sulfotransferase
kinetic law: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_47482d76_971f_418a_a0f6_899a8768129a
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: P26572
initial concentration: NaN
name: MGAT1
is encoded by: hsa:4245
initial amount: NaN
type: Species

metaM CE5132 c
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57923
has only substance units: false
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

metaM 13 cis retn r
is: HMDB06219
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
name: 13-cis-retinoate

http://identifiers.org/biomodels.db/MODEL1310110039#_a9528368_6aa9_482e_80ab_8bc466398726
is: SBO:0000252
name: MTMR2
is: A6NN98
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8898
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR B3GALTg
fast: false
name: Beta galactosyltransferase
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ
kinetic law: MODEL1310110039#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_9c51fdba_0410_49c7_9316_5cd109cbac27
is: B4DY56
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:498
constant: false
name: ATP5A1
initial amount: NaN
initial concentration: NaN

metaR DLNLCGt
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110039#
reversible: true
fast: false

metaM cdpdag hs m
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
is: SBO:0000247
name: CDP-diacylglycerol(2-)

metaR LINKDEG2ly
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
reversible: false
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110039#_300fc3f1_d912_4637_9269_394563ecf4a2
is encoded by: hsa:AI971023
constant: false
name: _AI971023_1_c
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_0270fe5c_ba69_42f0_ae4e_d10d2e5a224b
is encoded by: hsa:2679
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
name: GGT3P
has only substance units: false
is: SBO:0000252

metaM cspg b l
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB02183
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: CHEBI:36005
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
has only substance units: false
type: Species

metaR TRIODTHYt2
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110039#
fast: false
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
reversible: true
name: T3 transport via facilitated diffusion
is: SBO:0000185

metaR CDPDAGtm
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport
product: MODEL1310110039#
reactant: MODEL1310110039#

metaR r0472
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM CE5121 m
is: SBO:0000247
boundary condition: false
is: CHEBI:57449
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
name: trans-3-decenoyl-CoA
type: Species
has only substance units: false
constant: false

metaM glyclt x
is: HMDB00115
initial concentration: 1.0
has only substance units: false
name: glycolate
is: CHEBI:29805
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_edc8800f_cb2c_49d5_88b6_7207897b2805
has only substance units: false
is encoded by: hsa:4717
name: NDUFC1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: O43677
boundary condition: true

metaM em2emgacpail prot hs r
boundary condition: false
is: SBO:0000247
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2X CHARGE: 0
is: HMDB00086
is: CHEBI:16870

http://identifiers.org/biomodels.db/MODEL1310110039#_1eed5c9f_0a5a_4f8e_839e_09602b612236
name: SLC7A8
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q9UHI5
is: SBO:0000252
is encoded by: hsa:23428

metaM pan4p m
initial concentration: 1.0
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
type: Species
is: CHEBI:47942
boundary condition: false
is: HMDB01416
is: SBO:0000247
has only substance units: false
name: pantetheine 4'-phosphate(2-)
initial amount: NaN

metaR VALt5m
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110039#
name: Valine reversible mitochondrial transport
is: SBO:0000185

metaR S23T4g
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
type: Reaction
reactant: MODEL1310110039#
name: beta-galactoside alpha-2,3-sialyltransferase

http://identifiers.org/biomodels.db/MODEL1310110039#_ba09b46f_a40c_4f35_a3a0_8e950b19cbf7
constant: false
name: FOLR3
initial amount: NaN
is: Q05C14
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2352
has only substance units: false

metaM pheacgln c
is: SBO:0000247
type: Species
initial concentration: 1.0
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
is: HMDB06344
constant: false
is: CHEBI:58310
has only substance units: false
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110039#_c3c9737e_0703_4da4_9fa9_ec7fb52de6a0
name: NDUFA3
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4696
is: O95167
has only substance units: false
initial concentration: NaN

metaM hdd2crn c
initial amount: NaN
is: HMDB06317
initial concentration: 1.0
name: trans-Hexadec-2-enoyl carnitine
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
type: Species

metaM 5mthf c
type: Species
boundary condition: false
name: 5-Methyltetrahydrofolate
is: HMDB01396
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
constant: false
is: SBO:0000247
is: CHEBI:3729

http://identifiers.org/biomodels.db/MODEL1310110039#_da9b2635_183e_4401_91ce_e3fd658668fd
initial concentration: NaN
is encoded by: hsa:2182
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: O60488
type: Species
initial amount: NaN
name: ACSL4

http://identifiers.org/biomodels.db/MODEL1310110039#_2a73c07a_734b_49da_a53c_b9796e35f28d
constant: false
is: P48735
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3418
name: IDH2
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_643997c9_5808_49da_b317_9cea3277dcbc
is encoded by: hsa:8879
type: Species
has only substance units: false
is: O95470
initial amount: NaN
name: SGPL1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR r0475
product: MODEL1310110039#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_d78b6c58_a89a_47e7_bb66_0ff8d8460b23
is: SBO:0000252
constant: false
has only substance units: false
name: SLC7A9
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P82251
is encoded by: hsa:11136
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_872899eb_0211_43ac_8195_40d4d5aac557
is: SBO:0000252
type: Species
is encoded by: hsa:4967
constant: false
is: Q02218
has only substance units: false
initial amount: NaN
name: OGDH
initial concentration: NaN
boundary condition: true

metaR PI345P3P
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD

metaR RE3347C
kinetic law: MODEL1310110039#
fast: false
name: RE3347
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000

metaM hs deg12 l
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
has only substance units: false
is: HMDB01352
is: CHEBI:17180
name: heparan sulfate, degradation product 12
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b086c817_202f_4aaf_ae06_e8c51f55dafa
constant: false
type: Species
name: SLC22A2
initial concentration: NaN
is: O15244
is encoded by: hsa:6582
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM cspg a e
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:17568
is: C00106
type: Species
has only substance units: false
constant: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial concentration: 1.0
is: HMDB00300
boundary condition: false
initial amount: NaN

metaR r0474
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110039#_99c5e6a6_127d_4c5c_b70b_6547bb6632e5
type: Species
initial amount: NaN
constant: false
name: PRDX1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5052

metaR CYANt
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (extracellular to cytosol)
is: SBO:0000185
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_acfd743f_9903_49ad_8477_5920ce68ef65
type: Species
is: SBO:0000252
name: PANK1
is encoded by: hsa:53354
is: Q8TE04
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#

metaR FAOXC3DC
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaR MG3er
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
fast: false
is: SBO:0000176
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR A4GNT2g
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
type: Reaction

metaM thcholstoic c
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
is: CHEBI:18402
has only substance units: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM fuc1p L c
has only substance units: false
constant: false
is: CHEBI:28319
is: SBO:0000247
is: HMDB01265
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: L-Fucose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110039#_7fe8f45f_d240_495c_97fd_204702ebe114
name: ATP1A1
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:476
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B7Z3U6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_6145518a_3d91_47e3_901d_959d4c1a7ff6
is encoded by: hsa:203
constant: false
initial concentration: NaN
is: P00568
initial amount: NaN
boundary condition: true
has only substance units: false
name: AK1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_bc116ffb_97bf_4a7d_9acd_e279b7751593
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: SLC5A12
boundary condition: true
initial amount: NaN
is encoded by: hsa:159963
is: Q1EHB4
constant: false

metaR A4GALTg
reactant: MODEL1310110039#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.228
name: Lactosylceramide 4-alpha-galactosyltransferase
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false

metaR GLYCLTtp
product: MODEL1310110039#
name: glycolate transport into peroxisome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
fast: false

metaM ksi pre25 g
type: Species
is: C00130
is: HMDB00175
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 25
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58053
notes: FORMULA: C199H319N14O163S7X CHARGE: -8

metaM tmndnc e
is: HMDB01999
has only substance units: false
constant: false
is: SBO:0000247
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/446284
initial amount: NaN
type: Species
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
boundary condition: false

metaR CYSGLTH
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
fast: false
reversible: true
name: Glutathione:cystine oxidoreductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reactant: MODEL1310110039#

metaM 4hexdtricoa m
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02288
name: 4,7,10-hexadecatrienoylcoa
constant: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaR GALt1r
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
modifier: MODEL1310110039#
reversible: true
fast: false
product: MODEL1310110039#
name: galactose transport (uniport)
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

metaM HC00319 m
type: Species
is: CHEBI:30794
initial amount: NaN
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM n2m2nmasn e
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false
is: C04946
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false

metaR GluForTx
modifier: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.5
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
product: MODEL1310110039#
name: Glutamate formimidoyltransferase
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
type: Reaction
reactant: MODEL1310110039#

metaR PRGSTRNt
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#
name: Progesterone transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: true
is described by: ECO:0000000

metaR TCHOLAte
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: bile acid intracellular transport
type: Reaction
fast: false

metaR ENO
kinetic law: MODEL1310110039#
is described by: ECO:0000134
reversible: true
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.11
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
name: enolase
fast: false
is: SBO:0000176

metaR SUCOASm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
fast: false
is: SBO:0000176
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110039#
reversible: true
type: Reaction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_ef04f66e_0ce3_4ce3_b644_556beddf2100
is: O00624
type: Species
name: SLC17A2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10246
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaM HC02206 e
is: CHEBI:57399
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
constant: false

metaR G6PDH1rer
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000269
kinetic law: MODEL1310110039#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum

metaM cs c deg3 l
is: HMDB00127
initial concentration: 1.0
is: CHEBI:15748
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
is: SBO:0000247
type: Species
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_bb5ea07e_1c2c_4fe2_9019_48b5adb18bb3
name: HEXA
initial concentration: NaN
constant: false
is: P06865
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3073
initial amount: NaN

metaM succoa m
is: HMDB01022
is: CHEBI:57292
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Succinyl-CoA
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR AKGDm
reactant: MODEL1310110039#
is described by: ECO:0000134
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-oxoglutarate dehydrogenase
is version of: http://identifiers.org/ec-code/2.3.1.61
reversible: false
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR CSPG Etly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
name: chondroitin sulfate E transport, extracellular to lysosome
product: MODEL1310110039#
reversible: false
is: SBO:0000185

metaR SPHK21c
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.91
name: sphingosine kinase 2
fast: false
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_620c9fce_1f10_4cfb_a212_a2d5c9855252
is encoded by: hsa:7498
constant: false
is: P47989
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: XDH
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_d3d9983d_c5ac_43b0_8c4e_45135e35602e
initial concentration: NaN
is encoded by: hsa:2584
constant: false
is: P51570
name: GALK1
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM cs a deg4 l
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
is: CHEBI:57455
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01354

metaM itacon m
is: SBO:0000247
constant: false
is: HMDB02092
is: CHEBI:17240
has only substance units: false
name: itaconate(2-)
boundary condition: false
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial concentration: 1.0
initial amount: NaN

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM 3ivcoa c
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/11966188
constant: false
is: SBO:0000247
name: 3-hydroxyisovalerylcoa
initial amount: NaN
initial concentration: 1.0
is: C05998
boundary condition: false
is: HMDB06870

http://identifiers.org/biomodels.db/MODEL1310110039#_dcd26cfd_5acf_40ba_a5ac_ddb0522dc62f
has only substance units: false
initial amount: NaN
is: Q96SL4
constant: false
is encoded by: hsa:2882
type: Species
boundary condition: true
name: GPX7
is: SBO:0000252
initial concentration: NaN

metaR r1459
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true
product: MODEL1310110039#
type: Reaction
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_b6c32681_b624_4f99_8ca7_ec3e626abe67
is: O75521
is encoded by: hsa:10455
initial amount: NaN
name: ECI2
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_188289bc_3d69_4f55_8aaa_6765193dc0f2
type: Species
is: SBO:0000252
is: O15056
has only substance units: false
boundary condition: true
constant: false
name: SYNJ2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8871

http://identifiers.org/biomodels.db/MODEL1310110039#_e1365c9c_4bf6_49f6_bd2b_40eed82d448c
constant: false
has only substance units: false
initial amount: NaN
is: B4DZR2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8854
name: ALDH1A2
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_e1d6b2f8_5d99_4c1d_b16a_d84a9e62c88f
name: PLCH2
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9651
is: O75038
has only substance units: false
constant: false

metaM c10crn c
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C17H33NO4 CHARGE: 0
initial amount: NaN
name: decanoyl carnitine
is: HMDB00651
is: SBO:0000247
type: Species

metaM CE5101 m
constant: false
type: Species
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial amount: NaN

metaR ACETONEt2
reversible: true
name: acetone transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110039#
fast: false
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#

metaR r0149
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110039#
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39

http://identifiers.org/biomodels.db/MODEL1310110039#_57d1698d_09e8_4336_8511_ff52f924de2f
has only substance units: false
name: _AU149534_1_m
type: Species
is encoded by: hsa:AU149534
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
has only substance units: false
is: HMDB00222
name: L-palmitoylcarnitine
type: Species
constant: false
is: CHEBI:17490
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM tdcoa c
is: C02593
type: Species
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57385
has only substance units: false
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM lys L c
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
name: L-lysinium(1+)
is: CHEBI:32551
initial amount: NaN
is: HMDB00182

metaM ak2lgchol hs e
has only substance units: false
is: C04317
type: Species
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
constant: false
is: SBO:0000247
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
boundary condition: false
is: http://identifiers.org/pubchem.compound/6975
initial concentration: 1.0
initial amount: NaN

metaM CE4723 e
is: http://identifiers.org/pubchem.compound/5041
constant: false
notes: FORMULA: C29H40N5O9 CHARGE: -1 INCHI: InChI=1/C29H41N5O9/c1-16(2)24(26(39)31-20(11-12-23(36)37)28(41)34-14-4-6-22(34)29(42)43)32-25(38)21-5-3-13-33(21)27(40)19(30)15-17-7-9-18(35)10-8-17/h7-10,16,19-22,24,35H,3-6,11-15,30H2,1-2H3,(H,31,39)(H,32,38)(H,36,37)(H,42,43)/p-1/t19-,20-,21-,22-,24+/m1/s1 EHMN_ABBREVIATION: CE4723
type: Species
has only substance units: false
is: C01936
initial amount: NaN
name: neocasomorphin (1-5)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_851ef4a7_d574_4375_9a05_955159b06e25
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA203143
initial concentration: NaN
name: _AA203143_1_c
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR CSNAT2m
reactant: MODEL1310110039#
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: MODEL1310110039#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR Coqe
fast: false
name: Transport of q10
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_8addd23c_e882_4d7c_9247_6c0663a838f3
has only substance units: false
initial concentration: NaN
has part: Q6IB54
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:522

metaR ACCOALm
modifier: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110039#
name: acetate-CoA ligase (AMP-forming)
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
reversible: false
reactant: MODEL1310110039#
fast: false
is: SBO:0000176

metaM ocdececrn m
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06351
name: 11-octadecenoyl carnitine
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
type: Species
initial concentration: 1.0

metaM ca2 c
is: SBO:0000247
boundary condition: false
is: CHEBI:29108
initial concentration: 1.0
name: calcium(2+)
initial amount: NaN
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
type: Species
has only substance units: false
is: HMDB00464

metaM acrn m
boundary condition: false
name: O-acetylcarnitine
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
initial concentration: 1.0
is: CHEBI:57589
is: SBO:0000247
has only substance units: false

metaM tmndnc c
is: HMDB01999
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: timnodonic acid C20:5, n-3
has only substance units: false
is: http://identifiers.org/pubchem.compound/446284
type: Species
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7831d8c6_3e17_4a32_8d9a_21e23e436a85
initial concentration: NaN
type: Species
name: _AI291895_1_c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI291895
boundary condition: true
constant: false
initial amount: NaN

metaR r1786
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110039#
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#
name: Y+LAT2 Utilized transport
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_e18ef160_97b4_4007_9113_ac3a675e3d57
name: NT5C2
is: P49902
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:22978
has only substance units: false
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9303a8e3_25e4_4040_953a_ae2895b344d5
type: Species
name: CHST5
is encoded by: hsa:23563
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9GZS9

metaM glyclt c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29805
has only substance units: false
name: glycolate
is: HMDB00115
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaM elaid c
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
type: Species
name: elaidate
is: CHEBI:30825
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00573
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_11497432_82d2_472b_8605_1829f31fb493
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: Q92959
has only substance units: false
name: SLCO2A1
is encoded by: hsa:6578

http://identifiers.org/biomodels.db/MODEL1310110039#_6cf93777_ac0d_455c_a658_1c0c29dcb1a3
constant: false
is: A6NFM2
boundary condition: true
name: PYCR1
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5831

metaM lys L e
boundary condition: false
name: L-lysinium(1+)
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
is: SBO:0000247
is: CHEBI:32551
constant: false
has only substance units: false
type: Species

metaM HC02206 c
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
has only substance units: false
initial amount: NaN
name: prostaglandin C1(1-)
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_afa678ac_f31d_4655_bc28_6d633fa9bed2
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4701
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q6FG42
name: NDUFA7

http://identifiers.org/biomodels.db/MODEL1310110039#_740f9eb5_6221_4fb5_a666_b798e2a0b6a7
is: Q13011
constant: false
is encoded by: hsa:1891
type: Species
name: ECH1
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_e6ffdc35_014d_4adb_b492_28707e45b55e
is: SBO:0000252
is encoded by: hsa:84812
name: PLCD4
has only substance units: false
type: Species
initial amount: NaN
is: Q9BRC7
constant: false
boundary condition: true
initial concentration: NaN

metaM lnlccrn c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
constant: false
type: Species
name: Linoleyl carnitine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3bcbe529_9aa8_449d_8b15_ac9461cfb428
is encoded by: hsa:AV727634
constant: false
name: _AV727634_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaM cdpdag hs c
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
is: SBO:0000247
is: CHEBI:58332
initial concentration: 1.0
name: CDP-diacylglycerol(2-)
constant: false
initial amount: NaN
has only substance units: false

metaM ksi l
is: HMDB01354
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
type: Species
is: C00445
is: CHEBI:57455
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: keratan sulfate I
initial concentration: 1.0
has only substance units: false

metaM succoa c
initial amount: NaN
has only substance units: false
name: Succinyl-CoA
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247
is: HMDB01022
constant: false

metaR NACHEXA16ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false

metaR r0145
product: MODEL1310110039#
reversible: true
fast: false
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.8.3.1
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
type: Reaction
is described by: ECO:0000000

metaM acrn c
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
name: O-acetylcarnitine
has only substance units: false
is: CHEBI:57589
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR H3ETer
is: SBO:0000176
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD

metaR RETFAt
reversible: false
reactant: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: fatty acid retinol efflux
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false

metaR 5MTHFt2le
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: 5-methyltetrahydrofolate transport via anion exchange
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110039#

metaM dctp c
is: C00458
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: dCTP
is: HMDB00998
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311

http://identifiers.org/biomodels.db/MODEL1310110039#_6b1f9296_e9df_4b3c_9dc5_931250e98b47
name: DOLPP1
is encoded by: hsa:57171
is: Q86YN1
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_f5200162_eab6_41fb_b8f8_78076a6973f3
is: SBO:0000252
is: Q9BVK2
type: Species
is encoded by: hsa:79053
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: ALG8
constant: false

metaM acnam l
constant: false
is: HMDB00230
initial amount: NaN
has only substance units: false
is: CHEBI:35418
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

metaM dcacoa m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
boundary condition: false
is: SBO:0000247
is: HMDB06404
initial amount: NaN
is: C05274
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
type: Species

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM ksi pre16 g
initial amount: NaN
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 16
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58053
is: C00130
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR GTHOm
fast: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110039#
is described by: ECO:0000254
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
type: Reaction
name: glutathione oxidoreductase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_16b6073c_c2de_497f_a54c_ff68f4369914
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:57468
name: SLC12A5
is: Q9H2X9
initial concentration: NaN
boundary condition: true
constant: false

metaR NACHEX14ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1d5b6c63_e3be_4d43_ae34_cbc6df44b54a
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:50484
is: SBO:0000252
is: Q7LG56
initial amount: NaN
name: RRM2B
initial concentration: NaN

metaM dcsptn1 c
is: http://identifiers.org/pubchem.compound/5282848
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
has only substance units: false
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB13123

metaM n2m2nmasn l
is: C04946
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: SBO:0000247
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c26f57da_768f_42c4_a03a_6dfcaabd5a7b
type: Species
has only substance units: false
is: P17516
is: SBO:0000252
is encoded by: hsa:1109
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: AKR1C4
constant: false

metaM lneldccoa c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/9543677
constant: false
name: linoelaidyl coenzyme A
is: HMDB06521

http://identifiers.org/biomodels.db/MODEL1310110039#_420073df_b08a_4014_b65d_3a08a3af243b
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2678
name: GGT1
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM elaid e
initial concentration: 1.0
has only substance units: false
type: Species
name: elaidate
is: HMDB00573
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: CHEBI:30825

metaR RE1532M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
name: RE1532
is described by: ECO:0000000
type: Reaction

metaR r1450
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110039#
type: Reaction
name: EC:1.3.3.6
reversible: false
reactant: MODEL1310110039#

metaR PLA2 2
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110039#
name: phospholipase A2
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.4
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_7eb9f2f9_0627_429e_820e_1eb3d471b2b4
initial concentration: NaN
is: H0UI06
is encoded by: hsa:1347
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: COX7A2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_f35a7f63_1bb8_4281_b739_706963c012c3
name: ABP1
is: P19801
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26

metaM c10crn e
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: decanoyl carnitine
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: HMDB00651
notes: FORMULA: C17H33NO4 CHARGE: 0

metaM acnam n
initial amount: NaN
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: SBO:0000247
is: CHEBI:35418
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB00230

metaR NTD7e
type: Reaction
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000269
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110039#
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
name: 5'-nucleotidase (AMP), extracellular

metaR C16DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_41a232d5_47cf_4b0b_9b35_88a3cbef4739
constant: false
has only substance units: false
boundary condition: true
is: Q8TDQ7
initial concentration: NaN
is encoded by: hsa:132789
initial amount: NaN
is: SBO:0000252
name: GNPDA2
type: Species

metaM mn l
initial amount: NaN
has only substance units: false
type: Species
is: HMDB06535
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR r1451
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
product: MODEL1310110039#
name: EC:1.3.3.6
reactant: MODEL1310110039#

metaM m4masn g
boundary condition: false
constant: false
is: C05881
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0

metaR KCCt
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
name: K+-Cl- cotransport
is described by: ECO:0000269
modifier: MODEL1310110039#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

metaR RPI
reversible: true
kinetic law: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
name: ribose-5-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176

metaM dece4coa x
is: HMDB02145
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
boundary condition: false
name: 4-decenoylcoa
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR SIAT9g
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.9
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
modifier: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false

metaM cspg e l
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB02183
is: CHEBI:36005
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false

metaM prpp e
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:58017

metaR r1631
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true

metaR RE0944E
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#
fast: false
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0944
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM ksi g
is: HMDB01014
boundary condition: false
name: keratan sulfate I
is: SBO:0000247
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57255

metaR q10h2tc
is described by: ECO:0000134
kinetic law: MODEL1310110039#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110039#
reversible: true
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110039#

metaR RE2677G
kinetic law: MODEL1310110039#
name: RE2677
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
type: Reaction
is: SBO:0000176

metaR EX doco13ac
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR r1630
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
is: SBO:0000185

metaR r1453
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110039#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
fast: false
type: Reaction

metaR r0142
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
modifier: MODEL1310110039#

metaR DNDPt15m
reversible: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110039#
fast: false
name: dUDP transport via dGDP antiport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269

metaR TAURCHAe
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
reversible: false
type: Reaction
product: MODEL1310110039#
fast: false
name: exit of taurine from the enterocytes
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.

metaR FAOXC241C221x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaM xyl D c
has only substance units: false
is: SBO:0000247
name: aldehydo-D-xylose
is: CHEBI:15936
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
boundary condition: false

metaR C14STRr
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reversible: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
name: C-14 sterol reductase
type: Reaction
is described by: ECO:0000134
is: SBO:0000176

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_154f34d8_578a_4f99_b77d_21761bdf9428
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P03905
type: Species
name: ND4
is encoded by: hsa:4538

http://identifiers.org/biomodels.db/MODEL1310110039#_508903bc_5a82_458c_9bbb_53c32475b70a
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:1962
is: Q9NY65
name: EHHADH
initial amount: NaN
has only substance units: false

metaM prpp c
initial amount: NaN
is: CHEBI:58017
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
is: HMDB00280
has only substance units: false
initial concentration: 1.0
is: C00119
type: Species
name: 5-Phospho-alpha-D-ribose 1-diphosphate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1cecb0b5_cd9d_477c_8d8b_c9527703e8f7
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ACP1
is encoded by: hsa:52
is: B5MCC7

metaM ksi pre10 g
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 10
is: CHEBI:58053
initial concentration: 1.0
type: Species
is: C00130
initial amount: NaN
constant: false
is: HMDB00175
has only substance units: false
is: SBO:0000247
notes: FORMULA: C129H209N9O98S2X CHARGE: -3

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_39601ae4_0c9b_4c26_937c_b10aa3c1a107
has only substance units: false
is encoded by: hsa:AV713053
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AV713053_1_m
boundary condition: true

metaR ASNALANaEx
fast: false
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-asparagine Na-dependent exchange (Asn-L in)

metaR r1633
reactant: MODEL1310110039#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR RPE
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
name: ribulose 5-phosphate 3-epimerase
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110039#_08ef7824_bdc9_4e65_8a27_d402205b077e
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: SCD
has only substance units: false
is encoded by: hsa:6319
is: O00767

metaM ksi e
is: SBO:0000247
type: Species
name: keratan sulfate I
is: HMDB00211
constant: false
initial concentration: 1.0
is: CHEBI:17268
boundary condition: false
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false

metaR PHYCBOXL
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
modifier: MODEL1310110039#
name: L-Phenylalanine carboxy-lyase
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000212
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
is: SBO:0000176

metaM subeac x
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C8H12O4 CHARGE: -2
has only substance units: false
initial concentration: 1.0
name: suberic acid
constant: false
is: SBO:0000247
is: HMDB00893

metaM lnlccrn m
is: SBO:0000247
type: Species
name: Linoleyl carnitine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: HMDB06469
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_65f4bd13_2519_41a9_865b_1ebc9586b1b5
initial concentration: NaN
is: P52824
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1609
name: DGKQ
boundary condition: true
is: SBO:0000252
type: Species

metaR FUCASE2ly
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: alpha-fucosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110039#
type: Reaction
fast: false

metaR RE2677E
type: Reaction
is: SBO:0000176
name: RE2677
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
reversible: false

metaR GLYCTO1p
fast: false
kinetic law: MODEL1310110039#
reversible: false
product: MODEL1310110039#
is described by: ECO:0000269
name: Glycolate oxidase, peroxisome
is version of: http://identifiers.org/ec-code/1.1.3.15
type: Reaction
is: SBO:0000176
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD

metaM CE2420 m
initial concentration: 1.0
is: HMDB11123
constant: false
type: Species
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28387

metaM hs deg11 l
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57737
is: HMDB00868
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 11
notes: FORMULA: C55H81N3O67S7 CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110039#_83acb1f6_5a71_4427_ae3c_ab97e1f657b3
has only substance units: false
is: O00754
is encoded by: hsa:4125
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: MAN2B1
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d4f25527_f6ce_4387_b687_bac43d8130ae
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SDHC
is: Q99643
is encoded by: hsa:6391
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_5121a80d_26be_4e29_b093_5700f002d285
name: CHKB
is: A0PJM6
boundary condition: true
is encoded by: hsa:1120
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM xyl D e
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15936
has only substance units: false
initial concentration: 1.0
constant: false
name: aldehydo-D-xylose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_8e2983f7_dd42_437e_8641_f94e313d7164
is: SBO:0000252
boundary condition: true
is: Q02318
type: Species
initial concentration: NaN
name: CYP27A1
is encoded by: hsa:1593
has only substance units: false
initial amount: NaN
constant: false

metaR UDPGALtg
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000269
name: UDP-Gal Golgi transport via CMP antiport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaM dcsptn1 e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
is: HMDB13123
is: http://identifiers.org/pubchem.compound/5282848
has only substance units: false

metaR r1632
modifier: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
reversible: true

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

metaM thcholstoic r
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB03873
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

http://identifiers.org/biomodels.db/MODEL1310110039#_06b9ce38_e716_4848_9bff_484e0bec9850
initial amount: NaN
name: GLS2
type: Species
is: Q9UI32
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:27165
boundary condition: true
constant: false
has only substance units: false

metaR r2404
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
modifier: MODEL1310110039#

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_aad4f0ab_c734_4f5a_ab84_b68fab5e260b
is: SBO:0000297
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
has part: Q06055
is encoded by: hsa:517
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_f0227032_fd8f_49e4_90e9_4c3b1ad52b13
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3032
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: HADHB
constant: false
is: P55084

metaR SUBERICACT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaM c6crn c
has only substance units: false
constant: false
type: Species
is: HMDB00705
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H25NO4 CHARGE: 0
boundary condition: false
name: hexanoyl carnitine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_8f48b0c2_75fe_4456_8c25_f48d3d6f2f72
boundary condition: true
name: _AI684467_1_m
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI684467
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_b6954c74_8155_46ae_9e77_edc8719a8cb9
name: LHPP
is: Q9H008
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:64077
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_172f84cf_4d95_4996_8b18_391aca5608b9
has only substance units: false
is encoded by: hsa:8706
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is: O75752
name: B3GALNT1
boundary condition: true

metaR SPRMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
fast: false
is: SBO:0000185
name: absorption for spermine across the basolateral side
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000134

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: xylitol
boundary condition: false
is: CHEBI:17151
is: HMDB02917
initial concentration: 1.0
type: Species

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR r0178
product: MODEL1310110039#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reactant: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110039#

metaM spmd c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01257
name: Spermidine
is: SBO:0000247
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: C00315
is: CHEBI:57834

metaR GAMt1r
kinetic law: MODEL1310110039#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
name: glucosamine transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110039#_8c8534bd_992a_4282_989f_480b3bd7282a
is: A7E2E5
name: PDE3B
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5140
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaR r2535
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaR r1567
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
reactant: MODEL1310110039#

metaR H2Otp
is: SBO:0000185
fast: false
name: H2O transport, peroxisomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_f9674889_7231_4a6c_ac73_97e0097a912f
type: Species
boundary condition: true
is encoded by: hsa:5052
name: PRDX1
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR ASNSERNaEx
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
kinetic law: MODEL1310110039#

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR G5SADrm
reversible: true
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_d488a1fc_044b_482b_b586_8b4f427872c4
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P49748
name: ACADVL
initial concentration: NaN
is encoded by: hsa:37

http://identifiers.org/biomodels.db/MODEL1310110039#_acd870fd_0a41_41a5_9708_57d9651912fb
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NDUFA10
constant: false
is: O95299
is encoded by: hsa:4705

http://identifiers.org/biomodels.db/MODEL1310110039#_3b61f1c5_eeff_4604_8f61_0d10ebd8b8db
initial amount: NaN
is: O14732
constant: false
name: IMPA2
is encoded by: hsa:3613
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaR ACGAMPM
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/5.4.2.3
name: phosphoacetylglucosamine mutase
is described by: ECO:0000269
fast: false

metaR UPPDC1
product: MODEL1310110039#
is: SBO:0000176
fast: false
modifier: MODEL1310110039#
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
reversible: false

metaM o2 n
name: dioxygen
is: HMDB01377
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
initial amount: NaN
is: CHEBI:15379
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_90f326ef_626b_4367_a67e_2093facbfaf9
type: Species
has only substance units: false
boundary condition: true
name: VNN3
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55350
constant: false
is: SBO:0000252

metaM o2 m
is: C00007
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
name: O2
is: CHEBI:15379
is: SBO:0000247
is: HMDB01377

metaM HC02121 c
initial amount: NaN
type: Species
name: S-(hydroxymethyl)glutathione(1-)
has only substance units: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
boundary condition: false
is: CHEBI:58758
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_41a8d7ea_d016_4131_a9a2_17556bffc440
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: CA6
type: Species
constant: false
is encoded by: hsa:765
is: Q5FC00

http://identifiers.org/biomodels.db/MODEL1310110039#_0f6cbd99_439c_4ae5_ac4b_4b9beb358252
initial amount: NaN
initial concentration: NaN
constant: false
name: BCAT1
has only substance units: false
is encoded by: hsa:586
is: P54687
type: Species
is: SBO:0000252
boundary condition: true

metaR ARTCOAL3
type: Reaction
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
name: R group coenzyme a ligase
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
is described by: ECO:0000000
reversible: false

metaR S6TASE23ly
product: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
reversible: true
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR ADPACTD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6aef557e_d4ef_4103_ade7_cc70e9e9485d
has part: P21912
has only substance units: false
constant: false
name: SDHA:SDHB:SDHC:SDHD
initial amount: NaN
is encoded by: hsa:6389
is: SBO:0000297
boundary condition: true
is encoded by: hsa:6390
has part: P31040
type: Species
is encoded by: hsa:6391
is encoded by: hsa:6392
initial concentration: NaN
has part: Q99643
has part: O14521

metaR r1568
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaM vacccoa c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06521
constant: false
name: vaccenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110039#_e5bfff0f_f044_489d_b54a_c9f1c2d9f7c5
is: SBO:0000252
constant: false
initial amount: NaN
name: ADH1A
is encoded by: hsa:124
has only substance units: false
boundary condition: true
is: P07327
initial concentration: NaN
type: Species

metaM xylt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:17151
has only substance units: false
type: Species
name: xylitol
is: HMDB02917
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_923c1806_4674_4fe7_9b04_0628a2e4fb0a
is encoded by: hsa:30
is: SBO:0000252
is: Q96CA6
type: Species
name: ACAA1
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaR r1670
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR RE1521M
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1521
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
product: MODEL1310110039#
reactant: MODEL1310110039#

metaR LEUKTRE4t
reversible: true
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
name: leukotriene E4 transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110039#
is: SBO:0000185

metaR r1565
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#

metaR MACACI
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
name: maleylacetoacetate isomerase
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
product: MODEL1310110039#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9a5bbd62_18bf_4128_915c_92e6d92e3780
name: PPCDC
is: Q96CD2
initial amount: NaN
is encoded by: hsa:60490
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR FAOXC12DCx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR r0735
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176

metaM ksi pre24 g
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 24
constant: false
has only substance units: false
boundary condition: false
is: C00130
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
type: Species
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
initial amount: NaN

metaM dgchol x
is: HMDB00637
name: glycochenodeoxycholate
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
is: CHEBI:36252
boundary condition: false
has only substance units: false
constant: false

metaR r1671
type: Reaction
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#
reversible: true

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
fast: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16

http://identifiers.org/biomodels.db/MODEL1310110039#_91570ca2_d687_47dd_98a5_df39821545ee
is: SBO:0000252
is encoded by: hsa:51205
initial concentration: NaN
boundary condition: true
is: Q9NPH0
type: Species
initial amount: NaN
has only substance units: false
name: ACP6
constant: false

metaM gal e
name: D-Galactose
initial concentration: 1.0
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
is: CHEBI:0
initial amount: NaN
is: C00124
boundary condition: false
has only substance units: false
constant: false

metaR PItg
type: Reaction
kinetic law: MODEL1310110039#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: phosphate transport, Golgi apparatus
product: MODEL1310110039#

metaR r2534
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_51088801_1579_41e4_9f55_a5e6555c6a97
is: P30837
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:219
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: ALDH1B1

metaM fpram c
type: Species
constant: false
is: CHEBI:58478
is: SBO:0000247
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: HMDB06211
boundary condition: false
is: C04640
initial concentration: 1.0
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial amount: NaN
has only substance units: false

metaR r1566
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_9a3c5531_90dc_4aca_ae3e_4b5feccf214f
initial concentration: NaN
name: MTAP
boundary condition: true
is encoded by: hsa:4507
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is: Q13126
initial amount: NaN

metaR C10CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaM hspg e
type: Species
is: SBO:0000247
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:32366
constant: false
name: heparan sulfate proteoglycan
boundary condition: false
initial concentration: 1.0
is: HMDB02259
initial amount: NaN
has only substance units: false

metaM lnlncacoa m
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB06290
initial amount: NaN
is: SBO:0000247
name: alpha-Linolenoyl-CoA
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: CHEBI:51985

metaR 4MOPte
kinetic law: MODEL1310110039#
name: Transport of 4-methyl-2-oxopentanoate
fast: false
reactant: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110039#

metaM HC01399 m
initial concentration: 1.0
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:27466

metaM c16dc e
is: HMDB00712
name: Hexadecanedioic acid mono-L-carnitine ester
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H42NO6 CHARGE: -1
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR LGNCCOAtx
type: Reaction
name: fatty acid intracellular transport
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_f9d52a32_1d3c_4706_98fd_27130f61b853
constant: false
is encoded by: hsa:2530
name: FUT8
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q546E0
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_25eccd0f_7969_4dfd_995e_1cf775a5dc73
has only substance units: false
type: Species
name: AGXT2L1
boundary condition: true
is encoded by: hsa:64850
initial concentration: NaN
is: Q8TBG4
constant: false
initial amount: NaN
is: SBO:0000252

metaM o2 r
is: CHEBI:15379
is: C00007
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
boundary condition: false
has only substance units: false
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110039#_8d7eea99_f993_40aa_986f_f8aba521b68c
has only substance units: false
name: SDHB
is encoded by: hsa:6390
is: P21912
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM ach e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00895
has only substance units: false
name: acetylcholine
is: CHEBI:15355
initial amount: NaN
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false

metaR HSD3B12r
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus

metaR FAOXC184m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_15454722_3d27_4650_8c2f_682cad08dbf2
initial amount: NaN
is: Q9HBF5
constant: false
has only substance units: false
is encoded by: hsa:400410
boundary condition: true
type: Species
name: ST20
is: SBO:0000252
initial concentration: NaN

metaR r1841
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
reversible: false
type: Reaction
kinetic law: MODEL1310110039#

metaM andrstrn c
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species
initial amount: NaN
is: HMDB00031
name: androsterone
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16032
initial concentration: 1.0

metaR EX ddece1crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR PRISTCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
name: pristcoa peroxisomal transport
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR M4MPDOL Uter
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110039#
name: m4mpdol flippase
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM m8masn g
is: C05876
initial concentration: 1.0
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
is: SBO:0000247

metaR r1569
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
is: SBO:0000185
fast: false

metaR RE2666C
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
name: RE2666
fast: false

metaR r2537
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
name: Utilized transport
type: Reaction

metaM glygn2 e
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
has only substance units: false
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: HMDB00122
initial concentration: 1.0
is: CHEBI:4167

metaR 3HCO3 NAt
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: 3HCO3_NAt

metaM c16dc c
notes: FORMULA: C23H42NO6 CHARGE: -1
is: HMDB00712
name: Hexadecanedioic acid mono-L-carnitine ester
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR CITRtm
kinetic law: MODEL1310110039#
is described by: ECO:0000269
name: citrulline mitochondrial transport via proton antiport
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR SO4CLtex2
kinetic law: MODEL1310110039#
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
is described by: ECO:0000304
name: sulfate transport via chloride countertransport (2:1)
modifier: MODEL1310110039#

metaR GLCt4
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
name: glucose transport via sodium symport
is: SBO:0000185

metaR DCTPtn
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
name: dCTP diffusion in nucleus

metaR r0739
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
modifier: MODEL1310110039#
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

http://identifiers.org/biomodels.db/MODEL1310110039#_b489cab8_1710_474c_9500_8e81fd96a0bb
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: ELOVL2
is encoded by: hsa:54898
type: Species
boundary condition: true
has only substance units: false
is: Q9NXB9

metaR S6TASE12ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is: SBO:0000176
type: Reaction

metaR MALTt1r
is described by: ECO:0000269
name: maltose transport (uniport)
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
product: MODEL1310110039#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaR FAOXC102C81x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaM ksi pre3 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 3
is: C00130
type: Species
is: CHEBI:58053
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00175
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: SBO:0000247
constant: false

metaR r2538
fast: false
name: Utilized transport
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

metaR r1843
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110039#
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_906b02db_4d9b_44e6_9cde_e23cd4d71f52
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6342
is: C9JC79
name: SCP2
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM tmndnccoa c
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
name: timnodonyl coenzyme A
is: HMDB06514
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9170586c_4ce1_4362_ae1c_ca8d43ffdd7a
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q9ULC5
is encoded by: hsa:51703
name: ACSL5

metaM andrstrn e
initial concentration: 1.0
initial amount: NaN
name: androsterone
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: HMDB00031
boundary condition: false
type: Species
is: CHEBI:16032
is: SBO:0000247
constant: false

metaR DOLDPP Uer
kinetic law: MODEL1310110039#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.6.1.43
reactant: MODEL1310110039#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is: SBO:0000176
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR FAOXC184x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_65c18c13_c463_441d_87fa_9f47a3f73f7b
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: PIK3R1
initial concentration: NaN
is: SBO:0000252
is: B3KT19
is encoded by: hsa:5295
boundary condition: true

metaR PItn
type: Reaction
is: SBO:0000185
name: phosphate transport, nuclear
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110039#
fast: false
reversible: true
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_b44528ad_e6db_4785_8bfd_157759cd19e9
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6120
is: Q53TV9
has only substance units: false
initial amount: NaN
constant: false
name: RPE
type: Species

metaM hLkynr c
type: Species
name: 3-hydroxy-L-kynurenine
is: HMDB11631
has only substance units: false
initial concentration: 1.0
is: CHEBI:17380
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227

metaR r0730
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
modifier: MODEL1310110039#
reversible: false
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaM 3hpcoa m
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06807
initial amount: NaN
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: CHEBI:58528
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-hydroxypropanoyl-CoA(4-)

metaM HC01118 r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57310
name: presqualene diphosphate(3-)
initial amount: NaN
type: Species
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
has only substance units: false

metaR ALATHRNaEx
type: Reaction
name: L-alanine/L-threonine Na-dependent exchange (Ala-L in)
is: SBO:0000185
fast: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
reversible: false
product: MODEL1310110039#

metaR C141CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_1d556ad8_5622_4c73_96cf_fce2f909aa70
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q15392
is encoded by: hsa:1718
type: Species
name: DHCR24
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_cac07a07_4fbf_4e02_a316_cba811e5400b
has only substance units: false
is encoded by: hsa:10327
is: P14550
boundary condition: true
initial amount: NaN
constant: false
name: AKR1A1
initial concentration: NaN
type: Species
is: SBO:0000252

metaR CDIPTr
is: SBO:0000176
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.8.11
modifier: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
name: phosphatidylinositol synthase (Homo sapiens)
fast: false

metaM andrstndn r
is: HMDB00053
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
name: androst-4-ene-3,17-dione
has only substance units: false
is: CHEBI:16422
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_fee0df9d_0a54_48f2_8c5a_89bbfe14bfdb
has only substance units: false
name: RPN2
is: SBO:0000252
boundary condition: true
is: P04844
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6185
constant: false

metaR r1560
type: Reaction
kinetic law: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_2f07c630_420b_4aea_9502_fe6d22bd4854
name: GLRX2
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:51022
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_2cfd7d38_b6a6_4178_9d2f_426c3d72c935
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: ITPKB
constant: false
is: P27987
is encoded by: hsa:3707

http://identifiers.org/biomodels.db/MODEL1310110039#_dcb9ba7e_8d38_4774_9562_515795812102
name: SLC6A10P
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:386757
initial concentration: NaN

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM arachdcoa x
initial concentration: 1.0
is: HMDB06523
initial amount: NaN
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
is: CHEBI:57368
constant: false
name: arachidonoyl-CoA(4-)
has only substance units: false
type: Species

metaR SERGLYexR
product: MODEL1310110039#
is: SBO:0000185
reversible: true
type: Reaction
name: L-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000304
modifier: MODEL1310110039#

metaR r1950
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction

metaM 13dpg c
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
name: 3-Phospho-D-glyceroyl phosphate
is: SBO:0000247
is: HMDB01270
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3535
is: C00236
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57604

http://identifiers.org/biomodels.db/MODEL1310110039#_25de3a07_c5ee_445a_800a_93f78d7a2403
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6569
is: SBO:0000252
constant: false
name: SLC34A1
boundary condition: true
type: Species
is: Q7Z725

metaM HC01434 x
is: SBO:0000247
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
name: oxalatosuccinate(3-)
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58931

metaR GCCam
is: SBO:0000176
reversible: true
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoylprotein), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_ca61acc8_02b1_4b71_b308_96a92e9e3da3
constant: false
is: SBO:0000252
is encoded by: hsa:1607
initial amount: NaN
type: Species
boundary condition: true
is: Q9Y6T7
has only substance units: false
initial concentration: NaN
name: DGKB

metaR NADS2
is version of: http://identifiers.org/ec-code/6.3.5.1
kinetic law: MODEL1310110039#
name: NAD synthase (glutamine-hydrolysing)
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110039#
fast: false
reversible: false

metaM gal l
constant: false
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial amount: NaN
name: D-galactose
is: HMDB00143
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_89c8d16a_6326_470e_bf0f_2f68fb3f6118
initial concentration: NaN
is: Q9Y2Q0
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10396
is: SBO:0000252
type: Species
boundary condition: true
name: ATP8A1

metaR ECOAH9m
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_7eb32d91_a916_4ab8_b8b7_3883fa80a099
is encoded by: hsa:AI653169
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: _AI653169_1_c
initial amount: NaN

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
product: MODEL1310110039#
reversible: true
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_e582dcf5_bc9f_4dfd_8da2_db4596b7acc2
constant: false
name: PFKFB2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: O60825
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:5208

metaM fn2m2masn g
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:32984
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110039#_1a6f4982_2296_49da_ba57_c59d5686ac14
is: Q9H0N5
constant: false
initial amount: NaN
is: SBO:0000252
name: PCBD2
is encoded by: hsa:84105
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR GLNtN1
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110039#
name: Glutamine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110039#_4e8dd228_09ef_46ea_940f_e0907a8a2467
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: IDH2
initial concentration: NaN
is: P48735
is encoded by: hsa:3418
initial amount: NaN

metaR r1377
product: MODEL1310110039#
reactant: MODEL1310110039#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:

metaR r1952
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9aabc9ec_3f36_4fdc_bffa_438e6bef4295
is: Q9Y619
is: SBO:0000252
is encoded by: hsa:10166
has only substance units: false
initial concentration: NaN
name: SLC25A15
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM o2 x
type: Species
initial amount: NaN
is: C00007
boundary condition: false
is: CHEBI:15379
is: HMDB01377
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
is: SBO:0000247
initial concentration: 1.0
name: O2

metaR C10OHc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM 2pg c
has only substance units: false
is: HMDB03391
is: SBO:0000247
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
is: http://identifiers.org/pubchem.compound/3904
boundary condition: false
is: C00631
name: D-Glycerate 2-phosphate
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58289

metaM m8masn r
boundary condition: false
is: C05876
initial concentration: 1.0
notes: FORMULA: C70H117N2O55X CHARGE: 0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR r1563
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM dnad c
boundary condition: false
type: Species
name: Deamino-NAD+
is: HMDB01179
is: SBO:0000247
is: CHEBI:18304
initial amount: NaN
constant: false
is: C00857
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857

metaR r0734
is described by: ECO:0000000
product: MODEL1310110039#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_6951255c_c50e_4ee6_a1f2_00e8496bf288
initial concentration: NaN
is: G3V5N0
initial amount: NaN
name: FUT8
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2530
constant: false

metaR r2309
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110039#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110039#
fast: false

metaR UMPK6n
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
name: UMP kinase (dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110039#
type: Reaction
reversible: true
modifier: MODEL1310110039#
is described by: ECO:0000269

metaM CE2915 e
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C44H60N7O11 CHARGE: -1 INCHI: InChI=1/C44H61N7O11/c1-5-26(4)37(44(61)62)49-40(57)34-14-10-22-51(34)43(60)31(19-20-35(53)54)46-41(58)36(25(2)3)48-38(55)32(24-27-11-7-6-8-12-27)47-39(56)33-13-9-21-50(33)42(59)30(45)23-28-15-17-29(52)18-16-28/h6-8,11-12,15-18,25-26,30-34,36-37,52H,5,9-10,13-14,19-24,45H2,1-4H3,(H,46,58)(H,47,56)(H,48,55)(H,49,57)(H,53,54)(H,61,62)/p-1/t26-,30-,31+,32+,33-,34+,36-,37-/m1/s1 EHMN_ABBREVIATION: CE2915
is: http://identifiers.org/pubchem.compound/5041
name: beta-casomorphin
is: C01936
boundary condition: false
type: Species

metaR r1564
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
fast: false

metaM ach n
initial concentration: 1.0
is: HMDB00895
is: CHEBI:15355
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_7b6b3900_50d0_4b6e_89da_e2488217fb56
is encoded by: hsa:H17063
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: _H17063_1_c
boundary condition: true

metaR r0733
reactant: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_8e47c884_d5af_4a13_9d89_6af3e059c50d
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _206_1_c
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:206
boundary condition: true

metaR r2532
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR NRPPHRtu
reversible: true
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
name: Norepinephrine uniport

metaM 2obut c
initial amount: NaN
has only substance units: false
name: 2-Oxobutanoate
is: HMDB00005
is: CHEBI:16763
initial concentration: 1.0
is: C00109
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109

metaM tmndnccoa m
type: Species
is: HMDB06514
is: SBO:0000247
boundary condition: false
name: timnodonyl coenzyme A
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110039#_497bbbaa_41f9_4f07_a33b_4fed8471341c
constant: false
name: _U37519_1_e
is encoded by: hsa:U37519
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR AMPDA
reactant: MODEL1310110039#
name: Adenosine monophosphate deaminase
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.6

http://identifiers.org/biomodels.db/MODEL1310110039#_9cca902f_494b_4980_bbc7_56b5515e827c
is encoded by: hsa:5288
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: PIK3C2G
initial concentration: NaN
is: O75747
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b24c6afc_fa89_46e3_86d1_644962f32922
boundary condition: true
is encoded by: hsa:4724
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: O43181
initial concentration: NaN
name: NDUFS4
is: SBO:0000252

metaR RE2541E
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
product: MODEL1310110039#
name: RE2541
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
reversible: true
is: SBO:0000176

metaR URCN
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.49
kinetic law: MODEL1310110039#
is: SBO:0000176
name: URCN
reversible: false
product: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaM cholate e
constant: false
is: SBO:0000247
name: Cholate
initial amount: NaN
is: CHEBI:29747
is: HMDB00619
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
has only substance units: false

metaR r0732
fast: false
reversible: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction
is: SBO:0000176
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaM ksi deg36 l
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
name: keratan sulfate I, degradation product 36
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143

metaR S6TASE1ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
type: Reaction
reversible: true
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110039#

metaR r0437
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_fe45dc12_c4c0_451e_86f5_3fb8598705d2
is: SBO:0000252
has only substance units: false
name: ALDH1A3
boundary condition: true
initial amount: NaN
is encoded by: hsa:220
is: P47895
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_cc9de1d2_e8fc_4100_9168_88e2804ef759
has only substance units: false
name: _AI440329_1_r
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI440329
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaM hmgcoa c
name: Hydroxymethylglutaryl-CoA
boundary condition: false
has only substance units: false
is: HMDB01375
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
is: CHEBI:15467
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_60d6ccf2_1c87_45aa_abf8_0932a8f48813
boundary condition: true
has only substance units: false
constant: false
is: P24310
type: Species
name: COX7A1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1346

http://identifiers.org/biomodels.db/MODEL1310110039#_2a7cf752_7a7d_42dd_8fbc_b60f04ca5a34
name: ELOVL5
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:60481
is: F6SH78
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR r1167
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reversible: false
reactant: MODEL1310110039#
fast: false
name: EC:2.3.1.26

metaR r0731
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110039#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_d6f6c88c_fad8_4b3b_a732_d0b577ee3bbc
constant: false
initial concentration: NaN
is encoded by: hsa:1545
is: Q16678
has only substance units: false
name: CYP1B1
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM arachdcoa r
is: HMDB06523
boundary condition: false
is: SBO:0000247
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaR r1562
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110039#

metaM thbpt4acam n
initial concentration: 1.0
boundary condition: false
is: CHEBI:15374
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 4a-hydroxytetrahydrobiopterin
type: Species
constant: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281

metaR AG13T15g
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110039#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_cab2411f_88fe_4c5a_81e2_9778f550b075
is: Q9GZX3
name: CHST6
is encoded by: hsa:4166
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_6313b77b_7e27_4eef_958f_7baf01cf6365
is encoded by: hsa:AA664770
boundary condition: true
is: SBO:0000252
name: _AA664770_1_m
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaR r2308
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
fast: false

metaR EX fucfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leb glycolipid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6859475d_aa03_49fc_bddb_a511d5d8202d
name: SUCLG1:SUCLA2
has part: E5KS60
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:8803
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110039#_180c63a2_2b77_43b8_8531_8a63d21f80e2
is: SBO:0000252
type: Species
name: UMPS
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: A8K5J1
is encoded by: hsa:7372

metaM prgnlone m
is: CHEBI:16581
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
type: Species
is: HMDB00253
name: pregnenolone
initial concentration: 1.0
boundary condition: false

metaR RE2625C
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
name: RE2625
is described by: ECO:0000000
kinetic law: MODEL1310110039#

metaM cholate c
name: Cholate
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29747
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial amount: NaN
is: HMDB00619
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_15c09ce7_b368_4c73_892e_dfab090eb460
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ADH7
is: P40394
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:131

metaM 2hexdtricoa x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 2,7,10-hexadecatrienoylcoa
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02288
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d5e0cc26_5fde_42b1_aa7d_611b1f064b8a
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: GLS2
has only substance units: false
is encoded by: hsa:27165
initial concentration: NaN

metaR FAOXC18480m
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
name: Beta oxidation of fatty acid
fast: false
product: MODEL1310110039#

metaM prgnlone c
is: HMDB00253
is: SBO:0000247
type: Species
is: CHEBI:16581
boundary condition: false
constant: false
has only substance units: false
name: pregnenolone
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953

http://identifiers.org/biomodels.db/MODEL1310110039#_26345c19_4c4a_4e31_810a_5eadd5de1cb0
name: CA8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:767
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P35219
has only substance units: false

metaR LNELDCCPT1
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110039#
reversible: false
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

metaR C4STMO2Pr
reactant: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
name: C-4 methyl sterol oxidase
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
product: MODEL1310110039#

metaR r0434
reactant: MODEL1310110039#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110039#
product: MODEL1310110039#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false

metaR NH4t3r
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000269
name: ammonia transport via proton antiport
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false
type: Reaction

metaR FACOAL245 1
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
name: fatty-acid--CoA ligase
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d517511b_24f1_474c_8350_d90d81e27c04
initial amount: NaN
is: Q08828
is: SBO:0000252
constant: false
is encoded by: hsa:107
has only substance units: false
boundary condition: true
type: Species
name: ADCY1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_bb818c0b_04b6_4446_9d7f_d01a80fde702
is encoded by: hsa:AI915649
initial concentration: NaN
has only substance units: false
name: _AI915649_1_c
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM mi13p c
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
name: 1D-myo-Inositol 1,3-bisphosphate
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:18225
is: HMDB06234

metaR LNLNCGCRNt
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: false

metaM lnlc r
type: Species
name: linoleate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673
has only substance units: false
boundary condition: false
is: CHEBI:30245
constant: false
initial concentration: 1.0

metaR FAOXC226C225x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_3f6067a5_ca4e_4a59_8422_75166d6967be
is encoded by: hsa:55350
initial amount: NaN
has only substance units: false
name: VNN3
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaR r1380
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR LNELDCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110039#
reversible: false
fast: false
name: carnitine transferase
reactant: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110039#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_2efd5050_3659_4f58_8935_cfd068c556a9
is encoded by: hsa:56474
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: Q9NRF8
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: CTPS2

metaR r0580
modifier: MODEL1310110039#
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.7

metaM gcald c
name: glycolaldehyde
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17071
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB03344

metaM HC02179 c
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaR C161CPT22
is: SBO:0000176
name: C161 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
reversible: false

metaR FACOAL245 2
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
name: fatty-acid--CoA ligase
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false

metaM nad x
is: CHEBI:57540
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00003
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: HMDB00902
type: Species
name: Nicotinamide adenine dinucleotide
boundary condition: false

metaR AG13T17g
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_96a5d8ba_9b28_4dfb_b47b_dae20feef7c9
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: O95864
is encoded by: hsa:9415
type: Species
name: FADS2
boundary condition: true
constant: false

metaR 3MOBt2im
product: MODEL1310110039#
reversible: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
type: Reaction
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110039#

metaR PItx
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
name: Phosphate transporter, peroxisome
fast: false

metaM ei11ecoa x
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 11-eicosenoylcoa
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H68N7O17P3S CHARGE: -4

metaM e4p c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01321
name: D-Erythrose 4-phosphate
type: Species
is: CHEBI:16897
initial amount: NaN
constant: false
is: C00279
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279

metaR ADNtm
product: MODEL1310110039#
name: adenosine facilated transport in mitochondria
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaM dcsptn1crn m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
constant: false
is: HMDB06321
type: Species
has only substance units: false

metaR DASCBR
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.4.1
fast: false
kinetic law: MODEL1310110039#
name: dehydroascorbate reductase
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110039#_a87f7c1d_07b8_4ca1_b35e_d91c4d11139c
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ATP2B3
is encoded by: hsa:492
constant: false
is: Q16720
initial amount: NaN

metaR r1381
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5

metaR RE0383C
reversible: true
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
name: RE0383
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000000
modifier: MODEL1310110039#
is: SBO:0000176

metaR NDPK7n
modifier: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction

metaR ACOAD10m
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110039#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
modifier: MODEL1310110039#
type: Reaction

metaR CSNATm
modifier: MODEL1310110039#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110039#
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
is: SBO:0000176

metaR UMPK7n
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: UMP kinase (dGTP),nuclear
product: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false

metaM fuc L l
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18287
constant: false
type: Species
is: HMDB00174
initial concentration: 1.0
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
name: L-fucose

metaM prostgf2 e
initial concentration: 1.0
is: CHEBI:57404
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
is: HMDB01139
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: prostaglandin F2alpha(1-)
constant: false
has only substance units: false

metaR B3GNT39g
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
reversible: false
is described by: ECO:0000000
product: MODEL1310110039#
fast: false

metaM akg x
type: Species
is: CHEBI:16810
constant: false
initial concentration: 1.0
is: HMDB00208
name: 2-oxoglutarate(2-)
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247

metaR DRBK
reactant: MODEL1310110039#
is described by: ECO:0000304
fast: false
name: Deoxyribokinase
kinetic law: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.15
modifier: MODEL1310110039#
is: SBO:0000176
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaR 3MLDAt
is: SBO:0000185
name: 3MLDA extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
reactant: MODEL1310110039#

metaM tetpent6coa c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
name: tetracosapentaenoyl coenzyme A, n-6
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: C16172
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_bfce66c7_71ca_4072_b861_79417c450298
has only substance units: false
is: P07205
name: PGK2
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5232
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR C6DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_d4bdb915_5a81_4444_b5f4_340cf1b6d101
is: SBO:0000252
is encoded by: hsa:2877
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: GPX2
boundary condition: true
initial concentration: NaN
is: P18283

metaR RE0690E
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
name: RE0690
kinetic law: MODEL1310110039#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_88a647f0_c613_4cbb_9004_61bf87ed60f6
boundary condition: true
type: Species
is encoded by: hsa:3417
constant: false
is: O75874
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: IDH1
initial amount: NaN

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_7ec3495b_9909_4c10_8ef9_2a3e03bda377
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: O43426
is encoded by: hsa:8867
has only substance units: false
name: SYNJ1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8fa8aa3e_6f57_4450_873e_88077551feaa
initial amount: NaN
has only substance units: false
constant: false
is: P28330
is encoded by: hsa:33
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ACADL

http://identifiers.org/biomodels.db/MODEL1310110039#_6ed3600d_809b_43a2_ba95_bb458796b806
constant: false
name: DCK
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P27707
type: Species
is encoded by: hsa:1633
boundary condition: true
is: SBO:0000252

metaM CE2435 m
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
is: SBO:0000247

metaM lys L x
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
name: L-lysinium(1+)
type: Species
is: HMDB00182
is: SBO:0000247
has only substance units: false
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaR GALT
is version of: http://identifiers.org/ec-code/2.7.7.12
type: Reaction
modifier: MODEL1310110039#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
name: galactose-1-phosphate uridylyltransferase
is described by: ECO:0000000
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_0d379a7f_2083_497d_9316_36f7e5519b16
initial amount: NaN
name: HMOX1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:3162
is: SBO:0000252
is: Q6FH11

metaR G14Tg
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaR S6T13g
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110039#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8ec021ff_4c14_4242_b9f1_722e2fe945e8
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: GLS
is: O94925
is encoded by: hsa:2744
has only substance units: false
constant: false
boundary condition: true

metaM hdcoa c
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06532
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
has only substance units: false

metaM andrstrn r
is: CHEBI:16032
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
name: androsterone
type: Species
has only substance units: false
is: HMDB00031
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaR FUMtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is described by: ECO:0000269
fast: false
name: fumarate transport, mitochondrial
type: Reaction
reversible: true
is: SBO:0000185
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#

metaM hmgcoa m
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
constant: false
type: Species
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
initial amount: NaN
boundary condition: false
is: CHEBI:15467
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_1f7def4c_2fb5_439d_9959_2b378bbe4478
name: PSPH
initial concentration: NaN
is encoded by: hsa:5723
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: P78330
boundary condition: true

metaR GALU
product: MODEL1310110039#
is described by: ECO:0000134
modifier: MODEL1310110039#
name: UTP-glucose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
type: Reaction
reversible: true
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.9

metaR DIDPtn
is: SBO:0000185
reversible: true
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110039#
kinetic law: MODEL1310110039#
name: dIDP nuclear transport

metaR r1384
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
is described by: ECO:0000000
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#

metaR SBTR
reactant: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110039#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
name: D-sorbitol reductase
is: SBO:0000176

metaR r0584
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110039#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#

metaR FAOXC12DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaM dadp m
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57667
has only substance units: false
boundary condition: false
type: Species
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
is: HMDB01508

http://identifiers.org/biomodels.db/MODEL1310110039#_42084e57_223c_4bd9_aad8_629fe8702ad2
name: DGKZ
boundary condition: true
has only substance units: false
is: B7Z6M3
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8525
is: SBO:0000252

metaR ARACHCPT1
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
name: carnitine transferase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110039#

metaR FAS80COA L
is: SBO:0000176
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
product: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110039#
reversible: false
type: Reaction
reactant: MODEL1310110039#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaM o2 c
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
name: O2
initial concentration: 1.0
has only substance units: false
is: C00007
is: CHEBI:15379
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110039#_fa202b7a_8de4_4867_a030_88f1b593c9e0
initial amount: NaN
is encoded by: hsa:AI761708
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: _AI761708_1_m

metaR GASNASE3ly
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
kinetic law: MODEL1310110039#
name: glycosylasparaginase, lysosomal
type: Reaction

metaR THBPT4ACAMDASE
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110039#
is described by: ECO:0000269
reactant: MODEL1310110039#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395

metaM HC01434 m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false
name: oxalatosuccinate(3-)
is: CHEBI:58931
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_153a44f6_092b_4897_9099_a5ab5cee431d
type: Species
is: SBO:0000252
is encoded by: hsa:T83654
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: _T83654_1_c

metaM HC00319 c
is: CHEBI:30794
name: Malonate
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
initial amount: NaN

metaR ARACHCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110039#
name: carnitine transferase
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
reversible: false
is: SBO:0000176

metaM dadp n
initial concentration: 1.0
initial amount: NaN
is: HMDB01508
constant: false
is: SBO:0000247
is: CHEBI:57667
boundary condition: false
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
has only substance units: false

metaR 4MPTNLtm
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110039#
name: 4-methylpentanal transport (mitochondria)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_53d053a3_b48e_41c3_b741_c4275040a3dd
initial concentration: NaN
name: ST3GAL2
initial amount: NaN
is encoded by: hsa:6483
has only substance units: false
is: Q16842
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM 3mob m
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00019
has only substance units: false
is: CHEBI:11851
type: Species
boundary condition: false

metaR UGLT
name: UDPglucose--hexose-1-phosphate uridylyltransferase
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.7.12
fast: false
reversible: true
modifier: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction

metaM lnlc l
is: HMDB00673
is: CHEBI:30245
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_b295be37_a4f8_4b30_a134_259927ad63fe
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5140
is: SBO:0000252
initial concentration: NaN
type: Species
name: PDE3B
initial amount: NaN
is: Q13370

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_10bf438a_1f97_445f_8695_69b67cbd48b2
initial concentration: NaN
type: Species
name: SCD
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6319
boundary condition: true
is: O00767

metaR CYSTHRNaEx
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
name: L-cysteine/L-threonine Na-dependent exchange (Cys-L in)
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
fast: false

metaM HC02179 e
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
name: 20-hydroxy-arachidonate
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_d9452c0e_6513_46bc_9e0b_caf2ff761137
is: P36969
is: SBO:0000252
is encoded by: hsa:2879
initial concentration: NaN
type: Species
name: GPX4
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM nad r
is: CHEBI:57540
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
name: NAD(1-)
constant: false
is: HMDB00902
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c7d0d8f8_dede_4fef_8ec1_e94a4f62e8e4
name: PANK2
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:80025
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM adp r
is: SBO:0000247
has only substance units: false
is: HMDB01341
constant: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
boundary condition: false
is: CHEBI:456216
name: ADP(3-)
initial amount: NaN

metaR r0587
reactant: MODEL1310110039#
reversible: true
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is described by: ECO:0000000
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
modifier: MODEL1310110039#
is: SBO:0000176

metaM tettet6 c
initial amount: NaN
boundary condition: false
name: tetracosatetraenoic acid n-6
type: Species
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB06246
initial concentration: 1.0

metaR r0181
product: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR XOLDIOLONEt
product: MODEL1310110039#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
reactant: MODEL1310110039#
fast: false

metaM o2 e
is: HMDB01377
boundary condition: false
constant: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: SBO:0000247
initial amount: NaN
is: C00007
has only substance units: false
initial concentration: 1.0
is: CHEBI:15379

metaR NACHEX17ly
fast: false
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176

metaR CLHCO3tex2
name: chloride transport via bicarbonate countertransport (2:1)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000304
fast: false
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_9d6cf29b_f714_4137_b3e1_950e6ac66788
constant: false
boundary condition: true
type: Species
name: ACAA1
initial concentration: NaN
is encoded by: hsa:30
is: Q96CA6
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM ksii core2 deg7 l
type: Species
constant: false
name: keratan sulfate II (core 2-linked), degradation product 7
initial amount: NaN
boundary condition: false
notes: FORMULA: C44H73N4O30X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57455
has only substance units: false
is: HMDB01354

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_f12ff498_c738_4cae_86c0_6515930fda53
initial amount: NaN
is: Q14032
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:570
has only substance units: false
name: BAAT
initial concentration: NaN

metaM 3decdicoa x
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
name: 3,7-decadienoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966

metaM HC00695 m
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17432
initial amount: NaN
name: S-Succinyldihydrolipoamide
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
initial concentration: 1.0
constant: false
has only substance units: false

metaR DDECE1CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM 3ivcoa m
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/11966188
name: 3-hydroxyisovalerylcoa
is: C05998
initial concentration: 1.0
is: SBO:0000247
is: HMDB06870
initial amount: NaN
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false
type: Species

metaR CSNATr
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
is: SBO:0000176
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
name: carnitine O-acetyltransferase
type: Reaction
kinetic law: MODEL1310110039#

metaR HEXCOAACBP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false

metaM leuktrD4 e
is: HMDB03080
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
type: Species
name: Leukotriene D4
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM akg m
is: C00026
boundary condition: false
type: Species
is: CHEBI:16810
is: HMDB00208
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
name: 2-Oxoglutarate

http://identifiers.org/biomodels.db/MODEL1310110039#_071ef9d1_7ecd_4e3e_bcf3_49aeefefeeb0
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: SLC35A2
is: SBO:0000252
is: P78381
is encoded by: hsa:7355

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_40aec34e_f9da_4fe2_b929_33c410fc9099
is encoded by: hsa:AI345944
initial concentration: NaN
initial amount: NaN
name: _AI345944_1_m
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaM 12ppd S c
is: HMDB06213
initial amount: NaN
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
has only substance units: false
name: (S)-propane-1,2-diol
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:29002

metaM dcholcoa x
boundary condition: false
is: HMDB06292
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
type: Species
is: CHEBI:28701
constant: false
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a

http://identifiers.org/biomodels.db/MODEL1310110039#_9f21ab7e_f92b_45ff_8083_a8af7bbd0d64
name: _NM_001929_1_c
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:NM 001929
has only substance units: false

metaR DHCR71r
product: MODEL1310110039#
name: 7-dehydrocholesterol reductase
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#

metaR AG13T7g
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR GLCNACASE4ly
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110039#
modifier: MODEL1310110039#
name: alpha-N-acetylglucosaminidase, lysosomal

metaM vacccoa m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/9543677
name: vaccenyl coenzyme A
is: HMDB06521
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaR FRUt4
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
name: D-fructose transport via sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110039#_8d530ba0_9ded_4f71_bbd9_60301dc8f110
type: Species
constant: false
is: P28330
initial amount: NaN
boundary condition: true
name: ACADL
is encoded by: hsa:33
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM ksi pre19 g
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
is: C00130
name: keratan sulfate I biosynthesis, precursor 19
constant: false
type: Species
is: SBO:0000247
is: HMDB00175
has only substance units: false
boundary condition: false

metaM tettet6 e
has only substance units: false
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
type: Species
boundary condition: false
name: tetracosatetraenoic acid n-6
is: HMDB06246
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8ec22c36_af33_4dca_8146_12406ec4ba65
constant: false
initial amount: NaN
name: _AW277253_1_c
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AW277253

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: CHEBI:28067
initial concentration: 1.0

metaR MTHGXLt
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
kinetic law: MODEL1310110039#
type: Reaction
name: Methylglyoxal transport (cytosol to extracellular)

http://identifiers.org/biomodels.db/MODEL1310110039#_f79fb59b_d5c1_4832_b8af_0197d51753d1
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NME2
is: P22392
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4831
initial concentration: NaN

metaM nad m
name: Nicotinamide adenine dinucleotide
is: C00003
is: HMDB00902
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57540
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false

metaR LCADi D
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: lactaldehyde dehydrogenase
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
reversible: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_fc6f7df6_c3c9_4961_9607_cc64a49883dd
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9NYW8
has only substance units: false
is encoded by: hsa:57786
name: RBAK
initial amount: NaN
boundary condition: true

metaR RE2999M
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
name: RE2999
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
modifier: MODEL1310110039#

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaM ksi deg9 l
has only substance units: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
constant: false
boundary condition: false
type: Species
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate I, degradation product 9
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR G14T13g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
type: Reaction
modifier: MODEL1310110039#
fast: false
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90

metaM 4h2oglt m
type: Species
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
is: HMDB02070
initial amount: NaN
constant: false
is: CHEBI:17742

metaM leuktrD4 c
is: CHEBI:28666
name: Leukotriene D4
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
is: HMDB03080
initial amount: NaN
type: Species

metaM 2obut m
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
name: 2-oxobutanoate
has only substance units: false
is: CHEBI:16763

metaR PGI
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
fast: false
name: glucose-6-phosphate isomerase
kinetic law: MODEL1310110039#
reversible: true
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/5.3.1.9
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110039#

metaM 2hexdtricoa m
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
type: Species
constant: false

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaM gal c
constant: false
is: CHEBI:0
name: D-Galactose
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
has only substance units: false
is: HMDB00143
is: C00124
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR GLCNACASE3ly
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
is: SBO:0000176
modifier: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD

metaR RE0926E
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110039#
name: RE0926

http://identifiers.org/biomodels.db/MODEL1310110039#_d9eccdc2_80d3_4a38_a02a_69d7c88808e6
has only substance units: false
type: Species
is: P23378
name: GLDC
boundary condition: true
is encoded by: hsa:2731
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR HOCTDACBP
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM hs deg18 l
is: CHEBI:17180
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: heparan sulfate, degradation product 18
initial amount: NaN
is: HMDB01352

metaR LGNCt
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110039#
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110039#
reversible: true
is: SBO:0000185
fast: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM fuc L c
has only substance units: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: CHEBI:18287
constant: false
is: HMDB00174
is: SBO:0000247
type: Species
name: L-fucose
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_4efa5bf8_f9d7_4fc4_ac0f_d9c083f0fdfb
has only substance units: false
is: SBO:0000252
is encoded by: hsa:108
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: ADCY2
type: Species
is: Q71UM8

http://identifiers.org/biomodels.db/MODEL1310110039#_054fd214_2775_40ec_a3ed_184cad793c43
is: B4DKS0
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6566
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC16A1

http://identifiers.org/biomodels.db/MODEL1310110039#_25f5c011_26d4_4b97_8366_5e35dcb9a4a7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4712
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
constant: false
is: SBO:0000297
has part: Q5VYT2
is encoded by: hsa:4731
boundary condition: true
type: Species
has only substance units: false

metaR FAS180COA
name: fatty-acyl-CoA synthase (n-C18:0CoA)
reversible: false
type: Reaction
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR ACACT5p
reactant: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
type: Reaction
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110039#

metaR r0186
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reversible: false
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#

metaM dolmanp L r
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
constant: false
is: CHEBI:15809
initial concentration: 1.0

metaM dadp c
is: HMDB01508
type: Species
is: CHEBI:57667
initial amount: NaN
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
name: dADP
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: C00206

http://identifiers.org/biomodels.db/MODEL1310110039#_0eef09bb_779d_4829_b363_8065e5b22eef
initial amount: NaN
is: SBO:0000252
is: Q96QD8
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54407
boundary condition: true
name: SLC38A2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_40819dab_ea4b_4df0_8df7_fe7f3762cda4
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7001
type: Species
initial amount: NaN
has only substance units: false
name: PRDX2
initial concentration: NaN

metaR PGK
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: true
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.2.3
is described by: ECO:0000134
name: phosphoglycerate kinase
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_39850228_c92b_4b2c_8227_6104a16b7aee
constant: false
name: SLC37A4
initial amount: NaN
is encoded by: hsa:2542
initial concentration: NaN
is: A8K0S7
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR FAOXC1811602m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
name: Beta oxidation fatty acid
is: SBO:0000176
product: MODEL1310110039#
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR r1090
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110039#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR AMPtp
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
name: AMP transporter, peroxisome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#

metaR CYSSERNaEx
product: MODEL1310110039#
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reversible: false
reactant: MODEL1310110039#

metaM lnlc e
is: CHEBI:30245
type: Species
is: HMDB00673
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false
name: linoleate
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c6ad876d_31ac_4f14_8f70_fe2736cec272
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: PPCDC
type: Species
is encoded by: hsa:60490
is: SBO:0000252
is: Q96CD2
initial amount: NaN

metaM 3mob c
has only substance units: false
is: HMDB00019
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
constant: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0

metaR FAOXC2242046m
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
reversible: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false

metaR GLYOp
reactant: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: false
product: MODEL1310110039#
fast: false
is: SBO:0000176
name: glycine oxidase, perixosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:

metaM adp x
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01341
constant: false
initial amount: NaN
type: Species
name: ADP(3-)
boundary condition: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR FACOAL161
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
type: Reaction
product: MODEL1310110039#
name: fatty-acid--CoA ligase (hexadecenoate)
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR ESTRADIOLt
fast: false
name: estradiol transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185

metaR DM anth
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM hspg l
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
has only substance units: false
name: heparan sulfate proteoglycan
boundary condition: false
is: HMDB01993
is: CHEBI:17899
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_9519a03f_c399_4d05_bf7b_7c30180db10b
type: Species
has only substance units: false
name: UCK1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:83549
is: Q5JT09
initial concentration: NaN

metaR CYTK13n
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP),nuclear
type: Reaction
product: MODEL1310110039#
is described by: ECO:0000269
reversible: true

metaR RE3006M
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
name: RE3006
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110039#_494c012a_b602_4b48_9920_cfb1c9c44f7c
is: SBO:0000252
name: SLC5A7
is encoded by: hsa:60482
initial amount: NaN
has only substance units: false
is: Q9GZV3
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR GLUDxm
name: glutamate dehydrogenase (NAD) (mitochondrial)
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110039#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176
modifier: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
reversible: true

metaR r0885
is: SBO:0000185
kinetic law: MODEL1310110039#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
fast: false
reactant: MODEL1310110039#

metaR GALK
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is: SBO:0000176
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000000
name: galactokinase
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.157
type: Reaction
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.6

http://identifiers.org/biomodels.db/MODEL1310110039#_4e3db241_da9d_4480_8cb5_cc1968a75318
is encoded by: hsa:1178
name: CLC
is: SBO:0000252
initial concentration: NaN
is: C5HZ13
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true

metaM hdcoa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB06532
has only substance units: false
type: Species
initial concentration: 1.0
name: Hexadecenoyl-CoA (n-C16:1CoA)

metaR CSNATp
is described by: ECO:0000304
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
modifier: MODEL1310110039#
reversible: true
product: MODEL1310110039#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110039#
type: Reaction

metaR ASPDTDe
name: D-aspartate transport, extracellular
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_ae601194_8e2b_43ce_82e9_39020c792f7c
is: SBO:0000252
is encoded by: hsa:4702
type: Species
has only substance units: false
name: NDUFA8
is: B1AM93
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR PAIL4P HStn
type: Reaction
product: MODEL1310110039#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false

metaM lnlncacoa c
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: SBO:0000247
is: CHEBI:51985
name: alpha-Linolenoyl-CoA
boundary condition: false
constant: false
is: HMDB06290
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_629b4d32_bc8d_4ea6_9c82_0f70479e54ea
has only substance units: false
name: AKR1A1
is encoded by: hsa:10327
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR 4MPTNLte
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
name: 4-methylpentanal transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110039#

metaM 3mob e
is: SBO:0000247
has only substance units: false
type: Species
name: 3-methyl-2-oxobutanoate
constant: false
is: CHEBI:11851
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1

metaM ksi deg39 l
initial concentration: 1.0
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
name: keratan sulfate I, degradation product 39
constant: false
has only substance units: false
is: HMDB00143
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_0d53bc22_7e50_4d23_869d_fd4b760018e1
is: O75912
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:9162
name: DGKI
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR PUNP5
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: purine-nucleoside phosphorylase (Inosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110039#
fast: false
is described by: ECO:0000269
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reversible: true
type: Reaction

metaM dolmanp L c
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
is: CHEBI:15809
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Dolichyl phosphate D-mannose, human liver homolog

metaM hpdcacoa m
is: SBO:0000247
has only substance units: false
name: heptadecanoyl coa
is: HMDB06497
boundary condition: false
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_80f0ab69_8d89_4c4b_a508_ab663f0dfb2a
has only substance units: false
initial amount: NaN
is encoded by: hsa:5305
constant: false
is: SBO:0000252
name: PIP4K2A
boundary condition: true
initial concentration: NaN
is: P48426
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_87d69b5c_986b_445c_b1c3_1368c3ea07ec
is encoded by: hsa:2194
is: P49327
boundary condition: true
type: Species
name: FASN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaM prostge1 e
initial amount: NaN
is: CHEBI:57397
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB01442
initial concentration: 1.0
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaR r2521
reversible: true
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: Utilized transport

metaM nadp r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00006
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
is: SBO:0000247
is: HMDB00217
constant: false
name: Nicotinamide adenine dinucleotide phosphate

http://identifiers.org/biomodels.db/MODEL1310110039#_168c22b5_d5b2_47b2_a44c_5cd6647f2b2c
initial concentration: NaN
initial amount: NaN
name: GPX1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2876
has only substance units: false
type: Species
constant: false

metaR PUNP4
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#

metaR FAOXC122C101m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_04c63c32_1990_4c41_9e73_b6dd61a1df13
is: P31939
boundary condition: true
has only substance units: false
constant: false
name: ATIC
is: SBO:0000252
is encoded by: hsa:471
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_984c1b9f_978c_46fe_b052_872a31c58b4d
is encoded by: hsa:AA502753
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AA502753_1_m
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaR FAOXC183806m
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110039#
name: Beta oxidation of fatty acid
type: Reaction
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110039#

metaM 3decdicoa m
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
name: 3,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r1578
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR r0723
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110039#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR r1683
fast: false
type: Reaction
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_91ab1c2e_5afa_4fd7_a821_43d8fa064b66
is: Q99884
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC6A7
is: SBO:0000252
is encoded by: hsa:6534
type: Species
boundary condition: true

metaM ethamp r
has only substance units: false
is: CHEBI:58190
is: HMDB00224
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial concentration: 1.0
boundary condition: false
name: O-phosphonatoethanaminium(1-)
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_eb807f8a_f398_4d61_8dc6_cbfcf79b6111
type: Species
is: Q9NRR6
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:56623
name: INPP5E
is: SBO:0000252
initial concentration: NaN
constant: false

metaM m1mpdol U c
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial amount: NaN
is: CHEBI:28067
type: Species
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_d6092ae7_98dd_44c0_a2b7_965420a4af32
constant: false
type: Species
name: ATP10A
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O60312
is encoded by: hsa:57194
initial amount: NaN
has only substance units: false

metaR PUNP3
modifier: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Guanosine)
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: true
is: SBO:0000176

metaR r0726
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#

metaM 1pyr5c m
boundary condition: false
has only substance units: false
is: HMDB01301
is: CHEBI:15893
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
initial amount: NaN
is: C03912

http://identifiers.org/biomodels.db/MODEL1310110039#_cc29030f_647d_44a0_aef7_cf34297266e3
initial amount: NaN
name: _AW299740_1_m
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:AW299740

http://identifiers.org/biomodels.db/MODEL1310110039#_18061d06_a544_4530_87bd_17eef90d8a11
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:D29675
initial amount: NaN
initial concentration: NaN
name: _D29675_1_e
has only substance units: false
type: Species

metaM eitetcoa x
boundary condition: false
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
constant: false
has only substance units: false

metaR r1579
is: SBO:0000185
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#

metaM akg e
is: HMDB00208
initial amount: NaN
is: CHEBI:16810
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: 2-oxoglutarate(2-)
has only substance units: false
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

http://identifiers.org/biomodels.db/MODEL1310110039#_5a74bdfa_db55_4198_869b_c75629777ffb
constant: false
type: Species
is encoded by: hsa:513
is: P30049
initial amount: NaN
boundary condition: true
has only substance units: false
name: ATP5D
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_002af1c1_da00_4f76_8a52_32c6760bfd8d
is encoded by: hsa:54963
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: Q53HM1
boundary condition: true
name: UCKL1

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110039#
name: RE1520

metaR PUNP2
reactant: MODEL1310110039#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyadenosine)
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110039#

metaR r2310
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true
type: Reaction
is: SBO:0000185

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: linoleate
is: CHEBI:30245
is: HMDB00673

metaR r0870
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.7.72
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.1.3.4
name: Facilitated diffusion
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_f91a6f9c_844a_4a7d_b60b_2720fe246ac3
boundary condition: true
has only substance units: false
name: GALNT4
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q8N4A0
is encoded by: hsa:8693

metaR GLNSERNaEx
kinetic law: MODEL1310110039#
is: SBO:0000185
name: L-serine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
type: Reaction
reactant: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#

metaR PUNP1
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Adenosine)
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110039#

metaM dcholcoa r
has only substance units: false
type: Species
is: CHEBI:28701
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
initial amount: NaN
boundary condition: false
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0

metaR r0728
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
fast: false

metaR URAt
name: uracil transport via facilated diffusion
fast: false
reversible: true
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

metaM nadp m
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
has only substance units: false
is: C00006
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
type: Species
constant: false

metaR AG13T8g
modifier: MODEL1310110039#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110039#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
reactant: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110039#

metaM tetpent6coa x
boundary condition: false
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: C16172

metaR PSSA1 hs
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.29
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: Phosphatidylserine synthase homo sapiens
reversible: true
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ

metaR NACHEX19ly
reactant: MODEL1310110039#
reversible: false
is: SBO:0000176
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM xoltriol c
is: HMDB01457
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16496
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
has only substance units: false
type: Species

metaR r2311
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM akg c
type: Species
is: CHEBI:16810
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00026
name: 2-Oxoglutarate
initial concentration: 1.0
is: HMDB00208
constant: false

metaR r2525
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR UAG2EMAi
is version of: http://identifiers.org/ec-code/5.1.3.14
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
fast: false
reversible: false

metaM HC00718 c
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
constant: false
has only substance units: false

metaM HC02203 e
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
type: Species
constant: false
name: prostaglandin-a2
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d11a779f_05ac_47aa_9650_0c52a98124e3
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6648
constant: false
name: SOD2
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P04179

metaR r2312
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
initial amount: NaN
is: CHEBI:16236
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00108
constant: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110039#_6940d29c_cd4f_46ae_934e_07c64b93ffcf
is encoded by: hsa:5297
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: B4DYG5
name: PI4KA
initial concentration: NaN

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_b5398f9b_bdcd_4f0f_92fd_cacae13de5c1
initial amount: NaN
is: P40926
initial concentration: NaN
is encoded by: hsa:4191
name: MDH2
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3e88afd3_905d_4f27_b022_02270668e784
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: PNPO
is: Q9NVS9
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:55163

http://identifiers.org/biomodels.db/MODEL1310110039#_0ce284d1_ab32_4c64_8629_7f90644b3169
is encoded by: hsa:10020
is: B7Z428
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GNE
boundary condition: true
has only substance units: false

metaM 3aib D m
type: Species
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
boundary condition: false
name: D-3-Amino-isobutanoate
initial concentration: 1.0
has only substance units: false
constant: false
is: C03265
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_06ebee26_c92e_46f2_b943_e9a199278c69
is encoded by: hsa:18
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ABAT
type: Species
boundary condition: true

metaR r2526
reversible: true
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#

metaR MTHFR3
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.5.1.20
type: Reaction
modifier: MODEL1310110039#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
kinetic law: MODEL1310110039#
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_fac3bc42_e446_426d_bf2a_e0d896521dcc
constant: false
has only substance units: false
name: SULT1A1
initial amount: NaN
is encoded by: hsa:6817
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaR GLYt2r
type: Reaction
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000304
reversible: true
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110039#
product: MODEL1310110039#
name: glycine reversible transport via proton symport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_5982b703_194d_4724_9530_039408969d28
initial concentration: NaN
is encoded by: hsa:9551
constant: false
name: ATP5J2
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: P56134
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7cd58bca_4af8_41cf_be03_1ecff8f7386d
initial concentration: NaN
is encoded by: hsa:56301
constant: false
has part: Q9NS82
initial amount: NaN
name: SLC7A10:SLC3A2
boundary condition: true
is: SBO:0000297
has only substance units: false
is encoded by: hsa:6520
has part: P08195
type: Species

metaR r2313
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true

metaM hs deg16 l
is: SBO:0000247
name: heparan sulfate, degradation product 16
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:21338
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB02704
notes: FORMULA: C49H72N2O54S4 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110039#_dc391ea5_afb1_4ed7_8253_05b2fb7b880f
constant: false
is: SBO:0000252
initial amount: NaN
name: ADSSL1
has only substance units: false
is: B3KTV4
boundary condition: true
is encoded by: hsa:122622
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_93427e46_8944_4886_8d76_9c8639ceb20a
initial concentration: NaN
is: Q9NYQ3
type: Species
name: HAO2
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:51179
has only substance units: false
boundary condition: true

metaR BAAT1x
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
type: Reaction
modifier: MODEL1310110039#
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_bd1d6496_3820_41e3_b113_57e982376d4c
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:8560
has only substance units: false
constant: false
is: O15121
initial concentration: NaN
name: DEGS1

metaR DOLGLCP Uter
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#

metaM xol7aone c
has only substance units: false
is: CHEBI:17899
type: Species
boundary condition: false
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
is: SBO:0000247

metaM nad c
is: HMDB00902
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
is: CHEBI:57540
is: C00003
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_349a2d39_0283_4a27_b72a_7e6545d5a876
is: O43272
name: PRODH
has only substance units: false
is encoded by: hsa:5625
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR DURIPP
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: deoxyuridine phosphorylase
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
kinetic law: MODEL1310110039#
is: SBO:0000176

metaM HC02203 c
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
has only substance units: false
name: prostaglandin-a2
initial concentration: 1.0
type: Species
is: CHEBI:27820
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9b1877f9_37e6_4de8_a929_ea0ae1740b53
is: SBO:0000252
name: CMPK1
has only substance units: false
is: B2R6S5
initial amount: NaN
is encoded by: hsa:51727
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaM gln L m
constant: false
has only substance units: false
name: L-glutamine
initial concentration: 1.0
type: Species
is: HMDB00641
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaR PSP L
type: Reaction
name: phosphoserine phosphatase (L-serine)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.3.3
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:

metaR r2314
kinetic law: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_6fce9274_97fe_484a_b6d8_4b9ed3f0c761
type: Species
initial concentration: NaN
initial amount: NaN
name: GCK
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2645
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_cdb142e4_cc2c_4482_880e_6abdf07f65b9
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3081
name: HGD
type: Species
has only substance units: false
is: Q93099
is: SBO:0000252

metaR r2100
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_fe8862d1_b64d_450e_a24a_81253747d82b
constant: false
is: SBO:0000252
is: P36551
initial amount: NaN
type: Species
is encoded by: hsa:1371
has only substance units: false
initial concentration: NaN
name: CPOX
boundary condition: true

metaR r2315
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaM cs e deg3 l
has only substance units: false
is: HMDB00127
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748

metaR NACHEX10ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_735185cc_0aec_402d_9844_6af56ecdf5f6
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2539
name: G6PD
has only substance units: false
constant: false
boundary condition: true
is: P11413
type: Species

metaM mev R c
name: (R)-mevalonate
boundary condition: false
is: SBO:0000247
is: HMDB00227
initial amount: NaN
is: CHEBI:36464
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
has only substance units: false
type: Species

metaR r1088
is: SBO:0000185
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Active transport
reversible: true
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000

metaM 5pmev x
name: (R)-5-phosphonatomevalonate(3-)
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:58146
has only substance units: false
is: HMDB01343
constant: false
initial concentration: 1.0
type: Species

metaR r1570
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110039#

metaR r2316
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR GARFT
fast: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.1.2.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110039#
name: phosphoribosylglycinamide formyltransferase

metaM ocde9ecoa x
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: SBO:0000247
name: 9-octadecenoylcoa
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110039#_23a7c543_0205_49a2_9b7d_db14bceb6edb
is: SBO:0000252
name: ACAD8
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27034
constant: false
is: Q6ZWP6
type: Species

metaM Ssq23epx r
name: (S)-2,3-epoxysqualene
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB01188
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15441
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054

http://identifiers.org/biomodels.db/MODEL1310110039#_1f62eef6_7a76_444a_bd7c_b321238d3c1f
boundary condition: true
initial amount: NaN
name: B3GNT3
constant: false
is: Q9Y2A9
is: SBO:0000252
is encoded by: hsa:10331
has only substance units: false
type: Species
initial concentration: NaN

metaR PEt
kinetic law: MODEL1310110039#
fast: false
name: phosphatidylethanolamine transport
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_ea709d5a_e0e3_4270_b58f_a6459d45f33f
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:54965
type: Species
is encoded by: hsa:93183
has part: Q9H3S5
is: SBO:0000297
name: PIGX:PIGM
has only substance units: false
boundary condition: true
has part: Q8TBF5

metaM nadp x
is: C00006
type: Species
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
constant: false
is: CHEBI:58349
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: HMDB00217
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_0ec10e06_46f9_43c0_9843_47456bceb7f3
initial concentration: NaN
is encoded by: hsa:4724
is: O43181
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: NDUFS4
type: Species

metaR r2317
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_05b69feb_a992_4180_af6c_27cdbcb1d949
initial concentration: NaN
initial amount: NaN
name: RRM2B
is encoded by: hsa:50484
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is: Q7LG56
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_429aefcb_40ae_4810_b224_2a668f3156a2
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AA021081_1_r
is encoded by: hsa:AA021081
has only substance units: false
initial amount: NaN

metaR r1571
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r1150
type: Reaction
fast: false
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_2f9e92a5_e6ea_420e_8951_f7bdabb0770e
is encoded by: hsa:6508
is: SBO:0000252
initial amount: NaN
is: P48751
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: SLC4A3

metaM mgacpail hs r
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
type: Species
is: CHEBI:7896
is: HMDB00220
is: SBO:0000247
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00249

http://identifiers.org/biomodels.db/MODEL1310110039#_cbf7b0fc_adb4_4f38_9f61_0a119172ddb4
constant: false
is encoded by: hsa:5728
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: PTEN
initial amount: NaN
is: F6KD01
is: SBO:0000252

metaR KHte
is: SBO:0000185
type: Reaction
product: MODEL1310110039#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: KHte
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#

metaM ttdcrn c
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
boundary condition: false
name: tetradecanoyl carnitine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB05066
is: http://identifiers.org/pubchem.compound/3413344
constant: false

metaR RE1810M
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1810
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_771bba5f_c2b6_43be_8a55_9e3dc0c69283
constant: false
is encoded by: hsa:222
is: P48448
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ALDH3B2
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_3b1ea87e_7113_4aad_8130_cb060799ca63
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ALDH3A1
is encoded by: hsa:218
constant: false
is: P30838
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_49076d47_9d3f_48e5_a24c_8e4e489b95b6
is: Q9H999
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:79646
is: SBO:0000252
name: PANK3
boundary condition: true
type: Species
initial amount: NaN

metaR S6T11g
is: SBO:0000176
reactant: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
reversible: false
product: MODEL1310110039#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r2318
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110039#
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR ALAtN1
is: SBO:0000185
kinetic law: MODEL1310110039#
name: Alanine transport (Na, H coupled)
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR LEUKTRD4t
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is described by: ECO:0000269
reversible: true
product: MODEL1310110039#
fast: false
name: leukotriene D4 transport
is: SBO:0000185
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_d1d5ab0a_d650_4fbd_887a_972dbe9a171a
initial concentration: NaN
type: Species
is encoded by: hsa:8560
name: DEGS1
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_07769a4d_ff83_4766_a737_7987cc0897c0
has only substance units: false
name: DGKE
is: A1L4Q0
is encoded by: hsa:8526
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_1ecacf2f_9ae1_40d7_ba04_deff772de66d
name: IK
is encoded by: hsa:3550
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q13123

metaR ADA
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269
name: Adenosine deaminase
type: Reaction
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_29315f72_dc65_4744_a451_9646d97201e0
initial concentration: NaN
has only substance units: false
is: P17568
is encoded by: hsa:4713
is: SBO:0000252
name: NDUFB7
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM ksi deg21 l
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 21
has only substance units: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110039#_9ef6db77_e11e_4c6e_b308_45ccc7b95bba
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
name: _AI971036_1_m
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR DHCR243r
modifier: MODEL1310110039#
reactant: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
fast: false
is: SBO:0000176
name: 24-dehydrocholesterol reductase [Precursor]
kinetic law: MODEL1310110039#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
product: MODEL1310110039#

metaR r1573
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000000
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0720
product: MODEL1310110039#
reactant: MODEL1310110039#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8dda6d09_0097_4bb5_bff7_6de9f9682129
is encoded by: hsa:506
boundary condition: true
name: ATP5B
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P06576
constant: false

metaR 13DAMPPOX
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
type: Reaction
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is: SBO:0000176
is described by: ECO:0000212
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR UMPK5n
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: UMP kinase (dATP),nuclear
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_1f8508a9_cacf_4692_9f2a_3f7a5213fc30
is encoded by: hsa:1892
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ECHS1
is: SBO:0000252
is: P30084
type: Species

metaR DCK1n
is: SBO:0000176
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
name: Deoxycytidine kinase, nuclear (ATP)
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.74

metaR r2319
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_eb9594af_3bc7_4138_8b2f_3c58d085d206
type: Species
constant: false
is encoded by: hsa:5139
is: Q14432
name: PDE3A
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM 6pgc r
has only substance units: false
constant: false
is: CHEBI:58759
is: HMDB01316
is: SBO:0000247
name: 6-phosphonatooxy-D-gluconate
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaR r1155
is: SBO:0000185
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reactant: MODEL1310110039#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false
is described by: ECO:0000000

metaM g2m8mpdol U r
has only substance units: false
initial amount: NaN
is: CHEBI:59093
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110039#_88fa688e_a36f_46de_9be6_703bd17fb1fe
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54576
initial amount: NaN
boundary condition: true
name: UGT1A8
type: Species
is: Q5DSZ6

http://identifiers.org/biomodels.db/MODEL1310110039#_c2c65234_32f2_40e7_9b8a_7dc5cbfccfdc
is encoded by: hsa:5321
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P47712
name: PLA2G4A
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_b5eaba4a_50d1_484e_b004_23e3cb2d0772
initial concentration: NaN
constant: false
is: A8MYF6
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: MSMO1
initial amount: NaN
is encoded by: hsa:6307

metaR r1574
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM mi14p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282
initial concentration: 1.0
is: SBO:0000247
type: Species
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
is: HMDB00968
has only substance units: false
constant: false
initial amount: NaN

metaR r1154
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110039#
name: EC:1.2.7.2
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#

metaR GLCNACASE2ly
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110039#
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110039#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR r1575
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_f23b8bfb_7f85_450f_8ff7_43a5fff2ed7f
name: PDE2A
is: Q8IW54
is encoded by: hsa:5138
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_265af37f_08d1_4c94_a04f_f00eaadde334
initial amount: NaN
type: Species
is: P27144
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:205
name: AK4
constant: false
has only substance units: false

metaM gbside hs g
is: SBO:0000247
is: CHEBI:18259
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: globoside
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
constant: false

metaR r0722
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.3.12
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
type: Reaction
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#

metaM adn e
name: Adenosine
is: C00212
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16335
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00050

metaR PIPLC
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reversible: false
kinetic law: MODEL1310110039#
name: phosphatidylinositol phospholipase C
fast: false
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction

metaR PUNP7
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
name: purine-nucleoside phosphorylase (Xanthosine)
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaR KAS8
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
name: b-ketoacyl synthetase (palmitate, n-C16:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_0b57e3aa_5ebd_4a73_a4a6_ce7c2e03e05f
initial amount: NaN
constant: false
is: Q15067
has only substance units: false
name: ACOX1
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51
is: SBO:0000252

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01139
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: prostaglandin F2alpha(1-)
is: CHEBI:57404

http://identifiers.org/biomodels.db/MODEL1310110039#_c1dc8b7a_eafb_4d3c_8a00_c1a9bcb08f6f
is encoded by: hsa:728441
has only substance units: false
name: GGT2
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_5df80852_923a_49e3_8e22_98334f2d6fa1
is encoded by: hsa:AI024818
initial amount: NaN
name: _AI024818_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR RE1233C
product: MODEL1310110039#
name: RE1233
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000000
modifier: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side

http://identifiers.org/biomodels.db/MODEL1310110039#_7ccf0ee3_895b_47d2_a89a_310fd221ed95
type: Species
constant: false
initial amount: NaN
name: GGT2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:728441

metaR CERT1rt
product: MODEL1310110039#
reversible: true
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000304
reactant: MODEL1310110039#

metaR FAOXC163GC142m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r1576
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM adn c
is: HMDB00050
is: CHEBI:16335
is: C00212
has only substance units: false
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d376931c_fe16_4cac_8836_e691a4a9afcf
is: P43155
boundary condition: true
has only substance units: false
is encoded by: hsa:1384
name: CRAT
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaM CE4722 e
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
constant: false
notes: FORMULA: C38H49N6O10 CHARGE: -1 INCHI: InChI=1/C38H50N6O10/c1-22(2)32(35(50)40-27(16-17-31(46)47)37(52)44-19-7-11-30(44)38(53)54)42-33(48)28(21-23-8-4-3-5-9-23)41-34(49)29-10-6-18-43(29)36(51)26(39)20-24-12-14-25(45)15-13-24/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,49)(H,42,48)(H,46,47)(H,53,54)/p-1/t26-,27+,28+,29-,30+,32-/m1/s1 EHMN_ABBREVIATION: CE4722
name: beta-casomorphin (1-6)
boundary condition: false
is: C01936
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species

metaR r2520
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_6a0f8680_9970_49d0_895f_8febd88f862a
initial concentration: NaN
boundary condition: true
is encoded by: hsa:29922
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: NME7

metaR FAS120COA
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
product: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C12:0CoA)

metaR FAOXC161C161OHm
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR PUNP6
product: MODEL1310110039#
modifier: MODEL1310110039#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
fast: false
name: purine-nucleoside phosphorylase (Deoxyinosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110039#_8eea58c9_41f7_48af_9ac7_25e29c4fdf7a
name: MYO5B
is encoded by: hsa:4645
is: Q9H6Y6
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_89f6942e_8140_45d5_acee_5ade16107772
has only substance units: false
type: Species
is: P11169
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6515
boundary condition: true
name: SLC2A3
initial amount: NaN

metaM gln L c
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
name: L-glutamine
type: Species
initial concentration: 1.0
is: HMDB00641
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_70f6128c_b150_4514_a992_2f6cd21e9cfc
initial concentration: NaN
is: Q96N66
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:79143
boundary condition: true
constant: false
name: MBOAT7
has only substance units: false

metaM ksi deg19 l
constant: false
is: SBO:0000247
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
name: keratan sulfate I, degradation product 19
boundary condition: false
initial amount: NaN
is: HMDB01354
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57455

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR ADPACDAc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_4d260eec_ff7f_453a_a565_500f228b2a81
initial concentration: NaN
is: Q67FW5
initial amount: NaN
is encoded by: hsa:146712
boundary condition: true
name: B3GNTL1
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaR r1147
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000

metaM ump n
has only substance units: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
constant: false
is: HMDB00288
initial amount: NaN
name: UMP(2-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM lac D c
is: SBO:0000247
is: HMDB01311
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
name: (R)-lactate
is: CHEBI:16004
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_25030667_4643_4ebc_9b8b_b76706e82ed8
has only substance units: false
name: RDH5
constant: false
is: Q92781
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5959
initial concentration: NaN
boundary condition: true

metaM octa e
constant: false
has only substance units: false
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
is: C06423
is: SBO:0000247
initial concentration: 1.0
is: HMDB00482
boundary condition: false
initial amount: NaN
name: octanoate (n-C8:0)

metaR NADH2 u10m
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.6.5.3
is: SBO:0000185
name: NADH dehydrogenase, mitochondrial
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is described by: ECO:0000134

metaR FE2t
name: iron (II) transport
kinetic law: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_91201a8a_42c2_4a21_b9ac_5e5e5abc8fdc
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:114
type: Species
is: SBO:0000252
initial amount: NaN
is: Q4F7X0
initial concentration: NaN
name: ADCY8

metaM ksi pre18 g
constant: false
name: keratan sulfate I biosynthesis, precursor 18
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58053
initial amount: NaN
has only substance units: false
is: C00130
boundary condition: false
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
is: HMDB00175

metaR r0590
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: false
kinetic law: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#
is described by: ECO:0000000
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
product: MODEL1310110039#
fast: false
modifier: MODEL1310110039#

metaR r1148
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Active transport
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110039#

metaM HC02208 c
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: prostaglandin-d1
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_794b2bf2_e6cc_4d93_b5c0_5f2e110b592b
name: CPT1B
initial amount: NaN
is encoded by: hsa:1375
is: B7Z5T8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR CYTK14n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110039#
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_cb9290b6_c3df_4f78_9c29_84d445d9205f
has only substance units: false
is encoded by: hsa:4695
initial amount: NaN
constant: false
is: O43678
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFA2

http://identifiers.org/biomodels.db/MODEL1310110039#_25793478_dcfb_4430_be85_4d40558bce13
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: Q1LZ56
is encoded by: hsa:206358
name: SLC36A1
has only substance units: false

metaR RE3005M
is: SBO:0000176
reactant: MODEL1310110039#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110039#
name: RE3005
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaM 4mop m
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: HMDB00695
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
boundary condition: false
has only substance units: false
is: CHEBI:17865
initial concentration: 1.0
initial amount: NaN
constant: false

metaM pmtcrn m
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00222
is: CHEBI:17490
name: L-palmitoylcarnitine
initial concentration: 1.0

metaR r0591
fast: false
reactant: MODEL1310110039#
product: MODEL1310110039#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true
modifier: MODEL1310110039#
is described by: ECO:0000000

metaM lac D e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16004
constant: false
name: (R)-lactate
type: Species
initial concentration: 1.0
is: HMDB01311
has only substance units: false

metaR NDPK8n
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR FOLt2le
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110039#
fast: false
type: Reaction
reactant: MODEL1310110039#
name: folate transport via anion exchange
is: SBO:0000185
kinetic law: MODEL1310110039#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_b82508a1_5d23_4086_b027_e65a09253e89
initial concentration: NaN
constant: false
name: SLC6A8
is: SBO:0000252
initial amount: NaN
is: B4DIA3
is encoded by: hsa:6535
has only substance units: false
boundary condition: true
type: Species

metaR CORE4GTg
product: MODEL1310110039#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#

metaM octa c
boundary condition: false
is: CHEBI:25646
is: C06423
notes: FORMULA: C8H15O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: octanoate (n-C8:0)
is: HMDB00482
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_9e690038_4023_487f_ab4c_ca0b752b6a3e
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
type: Species
boundary condition: true
is encoded by: hsa:7991
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110039#_2b48ded2_ff01_45c6_9fe2_f88e8e3afe27
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:314
boundary condition: true
is: SBO:0000252
name: AOC2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_5e0f1ab1_07f6_47fb_8401_16ed1a315422
has only substance units: false
initial amount: NaN
is: Q8N9L9
name: ACOT4
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:122970

metaR SPC HSt
product: MODEL1310110039#
reversible: true
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185
type: Reaction
name: sphingosylphosphorylcholine transport (diffusion)
kinetic law: MODEL1310110039#

metaR RE3421R
kinetic law: MODEL1310110039#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000176
name: RE3421
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
type: Reaction
product: MODEL1310110039#

metaR 4NPHte
name: xenobiotic transport
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110039#
kinetic law: MODEL1310110039#

metaM datp c
is: SBO:0000247
name: dATP
is: CHEBI:61404
type: Species
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
initial amount: NaN
is: HMDB01532
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR NACHEX21ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#

metaR EX c10crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8336ec30_995d_4994_976f_26fc0ea6ebc5
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: SLCO1A2
initial concentration: NaN
is encoded by: hsa:6579
is: P46721
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_d3a00bd0_440b_4852_beeb_3b2253d8fce1
name: AKR1B1
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P15121
boundary condition: true
initial concentration: NaN
is encoded by: hsa:231

metaM HC02208 e
is: CHEBI:27696
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR AG13T16g
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110039#
is: SBO:0000176
product: MODEL1310110039#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110039#_141529d9_28cc_4bbe_8e7f_5a44671898f2
is: P47895
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:220
name: ALDH1A3
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_da84ff41_9aec_4a5b_b2e8_7e8bd78dbcab
type: Species
name: _U52111_1_c
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:U52111
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_2ae241fc_79e1_4ddb_90be_5094fe6d5e00
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: PIP5K1A
is: Q99755
is encoded by: hsa:8394

metaR S6T12g
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110039#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110039#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110039#
reversible: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM 3hdeccoa c
type: Species
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 3-hydroxyhexadecenoylcoa
constant: false
is: HMDB02014
initial amount: NaN
has only substance units: false

metaR GTHP
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110039#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
reactant: MODEL1310110039#
is described by: ECO:0000134

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR ADAe
type: Reaction
modifier: MODEL1310110039#
name: Adenosine deaminase, extracellular
fast: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is: SBO:0000176
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269

metaR TETPENT6t
fast: false
kinetic law: MODEL1310110039#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#

metaR ACNACNGALGBSIDEte
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
reversible: true
type: Reaction
is: SBO:0000185
name: acnacngalgbside hs transport
reactant: MODEL1310110039#
is described by: ECO:0000000

metaR ARGtm
modifier: MODEL1310110039#
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: arginine mitochondrial transport via ornithine carrier
type: Reaction

metaM CE1926 e
has only substance units: false
is: SBO:0000247
is: CHEBI:15748
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00127
name: gama-carboxyethyl-hydroxychroman
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_30e597bc_f083_49f9_9e97_bbdd46d4621b
boundary condition: true
has only substance units: false
type: Species
name: ADCY5
is: O95622
constant: false
is: SBO:0000252
is encoded by: hsa:111
initial concentration: NaN
initial amount: NaN

metaR NACHEX16ly
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: false

metaR PI345P5P
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
reactant: MODEL1310110039#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false
modifier: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110039#_939587a2_f9a9_49f5_a19e_dcd2f29b5239
is: SBO:0000252
is: A6NDW6
type: Species
initial amount: NaN
boundary condition: true
name: ALG8
is encoded by: hsa:79053
initial concentration: NaN
has only substance units: false
constant: false

metaM 3otdcoa m
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB03935
initial concentration: 1.0
is: CHEBI:28726
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
type: Species
initial amount: NaN
name: 3-Oxotetradecanoyl-CoA

metaR r0441
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110039#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR GTHO
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000254
fast: false
name: glutathione oxidoreductase
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR AG13T18g
is: SBO:0000176
product: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110039#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110039#

metaM ttdcrn m
name: tetradecanoyl carnitine
is: HMDB05066
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3413344

metaR r0594
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31

metaM C05279 m
has only substance units: false
is: CHEBI:28387
type: Species
constant: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
is: HMDB11123
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_f0375311_0fbd_4ed3_9d00_af91ffe45d7c
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:50
name: ACO2
is: Q99798
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM ala B m
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00056
is: CHEBI:16958
boundary condition: false
type: Species
initial concentration: 1.0
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR ATPtm
is: SBO:0000185
kinetic law: MODEL1310110039#
fast: false
reversible: false
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110039#
product: MODEL1310110039#
name: ADP/ATP transporter, mitochondrial
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaM em2emgacpail hs r
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
type: Species
is: HMDB03125
is: CHEBI:16240
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
constant: false

metaR S23T3g
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.6
product: MODEL1310110039#
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
reactant: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_af86c890_1783_41d5_b5b3_6a20d7f5644d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7991
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: Q13454
name: TUSC3

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

metaM dcholcoa c
is: CHEBI:28701
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
has only substance units: false
is: HMDB06292
is: SBO:0000247
constant: false
type: Species

metaM eitetcoa m
type: Species
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r1580
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
product: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8cbba0d0_ebc0_4e39_b040_433abd0f69ff
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q7GXZ1
name: ND6
initial amount: NaN
is encoded by: hsa:4541
initial concentration: NaN

metaR ACNACNGALGBSIDEtg
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110039#
type: Reaction
is: SBO:0000185
name: acnacngalgbside hs intracellular transport
fast: false
kinetic law: MODEL1310110039#
is described by: ECO:0000000
reversible: true

metaM urcan c
type: Species
is: HMDB00301
boundary condition: false
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
initial amount: NaN
is: CHEBI:17771
is: SBO:0000247
is: C00785
constant: false
has only substance units: false
initial concentration: 1.0

metaR MALT
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: alpha-glucosidase
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_dbb28564_9e98_4865_978a_37ab9a855eca
constant: false
is: O60476
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: MAN1A2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10905

http://identifiers.org/biomodels.db/MODEL1310110039#_da54e1fa_b6b2_4f9e_b606_63078514f474
is: B2RDZ2
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:55312
name: RFK
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaM adn m
constant: false
is: CHEBI:16335
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: adenosine
is: HMDB00050
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110039#_2e8c3aab_7824_421e_aa4b_447cec3c5403
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR CLPNDt
is described by: ECO:0000000
reactant: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM CE0849 m
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
initial amount: NaN
type: Species
constant: false
is: CHEBI:57795
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: cis,cis-palmito-7,10-dienoyl-CoA

metaR r0596
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reactant: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
modifier: MODEL1310110039#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ce88c1ed_6c7b_4922_b1a6_64d23d0adcb2
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:51292
boundary condition: true
is: SBO:0000252
name: GMPR2
constant: false
is: Q9P2T1
type: Species

metaR FAOXC4C4DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_4a815619_c187_4b18_900c_8715ab83329b
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:10400
name: PEMT
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR S6TASE13ly
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110039#
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
type: Reaction
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaM 3ddecdicoa m
initial concentration: 1.0
type: Species
is: C05280
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 3,6-dodecadienoylcoa
has only substance units: false
constant: false
is: HMDB03952
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM ade c
initial concentration: 1.0
is: CHEBI:16708
name: Adenine
is: C00147
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
is: HMDB00034
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_df0df8ca_3334_4d4e_875d_6a427373e4c1
is: P23434
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: GCSH
is encoded by: hsa:2653
initial amount: NaN

metaR PRO1xm
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
is described by: ECO:0000254
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.5.99.8
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
name: proline oxidase (NAD), mitochondrial
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_2be7b31c_16f3_4187_aecf_b085bd74a1ff
name: GLUD1
is: E9KL48
is: SBO:0000252
is encoded by: hsa:2746
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR ACHEe
is version of: http://identifiers.org/ec-code/3.1.1.7
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
kinetic law: MODEL1310110039#
name: Acetylcholinesterase
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_eaaa9bc5_fefd_4ce1_a677_5d4443ef38f8
is encoded by: hsa:134526
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: ACOT12
boundary condition: true
initial concentration: NaN
is: Q5FWE9
constant: false

metaM acnacngalgbside hs c
is: SBO:0000247
is: HMDB00223
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
constant: false
name: disialyl galactosylgloboside
is: CHEBI:3338
is: C00036

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM gar c
type: Species
is: HMDB02022
initial amount: NaN
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
name: N1-(5-Phospho-D-ribosyl)glycinamide
has only substance units: false
is: CHEBI:58457
is: C03838

metaM ach c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:15355
type: Species
initial amount: NaN
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
boundary condition: false
is: HMDB00895

metaR r2009
fast: false
kinetic law: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185

metaR FAOXC1811603m
reversible: false
kinetic law: MODEL1310110039#
fast: false
name: Beta oxidation fatty acid
is: SBO:0000176
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110039#_6e7f3731_7d53_47b2_834a_a6ee8437d3cb
has only substance units: false
constant: false
is: O95497
is: SBO:0000252
is encoded by: hsa:8876
initial concentration: NaN
type: Species
initial amount: NaN
name: VNN1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_a8ecb3ab_d8ac_4b87_bcec_18f9f0584592
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:6561
is: Q9BZW2
is: SBO:0000252
initial concentration: NaN
name: SLC13A1
initial amount: NaN

metaR FE3R2e
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (79901.1) SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11230685,PMID:12755454 NOTES:stoichiometry unknown; inferred from EC1.16.1.7 NCD
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110039#
product: MODEL1310110039#
name: Fe(III) reduction (ascorbate)
reversible: false

metaM ump g
boundary condition: false
initial concentration: 1.0
is: CHEBI:57865
is: SBO:0000247
name: UMP(2-)
has only substance units: false
type: Species
constant: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN

metaM pmtcrn x
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
is: CHEBI:17490
initial amount: NaN
constant: false
type: Species
is: HMDB00222
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM 5mdru1p c
boundary condition: false
is: SBO:0000247
is: CHEBI:58548
is: HMDB01299
initial concentration: 1.0
has only substance units: false
is: C04582
initial amount: NaN
constant: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
notes: FORMULA: C6H11O7PS CHARGE: -2
type: Species

metaM zymstnl r
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0
is: HMDB06841
is: CHEBI:16608
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: SBO:0000247

metaR MMSAD3m
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
fast: false
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_1178a7f4_254e_4e90_a04e_13dc9abdae21
has only substance units: false
constant: false
is encoded by: hsa:BE966236
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _BE966236_1_c
is: SBO:0000252

metaM strch1 e
is: SBO:0000247
type: Species
initial concentration: 1.0
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
is: HMDB00045
boundary condition: false
is: C00020
initial amount: NaN
notes: FORMULA: C66H112O56 CHARGE: 0
is: CHEBI:456215
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1d0e31bc_b117_4db5_9723_dcc2ff9eb535
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AU149534
initial amount: NaN
type: Species
name: _AU149534_1_e
initial concentration: NaN

metaR TRDR
fast: false
reversible: false
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:

metaR DHCR72r
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110039#
name: 7-dehydrocholesterol reductase
kinetic law: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_01661a97_454f_4fdd_bdce_bf9b7186f7d9
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:39
initial amount: NaN
name: ACAT2
is: Q9BWD1

http://identifiers.org/biomodels.db/MODEL1310110039#_2938a655_674a_4188_85aa_0ce63b788163
type: Species
initial concentration: NaN
has only substance units: false
name: SHMT1
is encoded by: hsa:6470
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR BTNt2
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
type: Reaction
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000269
name: Biotin reversible transport via proton symport
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110039#
reactant: MODEL1310110039#

metaM datp m
constant: false
initial amount: NaN
is: CHEBI:61404
has only substance units: false
type: Species
name: dATP
is: HMDB01532
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: SBO:0000247
is: C00131
initial concentration: 1.0

metaR GULN3D
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: L-gulonate 3-dehydrogenase
is: SBO:0000176
reversible: true
reactant: MODEL1310110039#
fast: false
product: MODEL1310110039#

metaR PTDCACRNCPT2
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
reactant: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
name: pentadecanoate transport into the mitochondria
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_e4c557fb_1d79_448f_9d71_c03991bada2f
initial concentration: NaN
is: P23786
is encoded by: hsa:1376
has only substance units: false
initial amount: NaN
name: CPT2
type: Species
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_b5f3cec6_6a07_40da_8732_e41ae69ef633
has only substance units: false
is encoded by: hsa:27124
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: INPP5J
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_26af36fe_b578_42b5_933c_f85797ffeab5
boundary condition: true
is: Q16706
name: MAN2A1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4124
constant: false
initial amount: NaN

metaM ade e
type: Species
is: SBO:0000247
is: HMDB00034
is: CHEBI:16708
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: adenine
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_67f05ef7_382a_407d_93f9_6a5fc09b5ead
is encoded by: hsa:AA177072
boundary condition: true
type: Species
name: _AA177072_1_x
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_3da2226d_d035_4910_945f_e0239d642beb
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA614647
name: _AA614647_1_c
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR 4NPHSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
reactant: MODEL1310110039#
fast: false
reversible: false
product: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
name: 4-Nitrophenol Sulfotransferase
modifier: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

http://identifiers.org/biomodels.db/MODEL1310110039#_b79be121_c09f_4fbd_ac5f_3e27cbdde78c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: PLCG1
has only substance units: false
is encoded by: hsa:5335
constant: false
initial amount: NaN
is: P19174

http://identifiers.org/biomodels.db/MODEL1310110039#_c2b43dfb_2f5f_49a0_949d_8d4873ab5b82
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: Q6UWQ5
is encoded by: hsa:84569
name: LYZL1

metaM hestratriol r
is: SBO:0000247
initial amount: NaN
name: 4,17 dihydroxy estradiol
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: HMDB05896
has only substance units: false

metaM 4mop e
is: SBO:0000247
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false

metaM 5mdr1p c
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate
constant: false
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:58533
initial concentration: 1.0
is: HMDB00963
notes: FORMULA: C6H11O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02120 EHMN_ABBREVIATION: C04188
is: C04188
initial amount: NaN

metaR r0170
reversible: true
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_cc70ca42_61ce_47ff_82c5_02da84068e37
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:AA278423
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AA278423_1_c
type: Species

metaM crm hs r
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:52639
initial concentration: 1.0
name: N-acylsphingosine
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_0772b4cd_b221_415b_921c_b45f5582d97d
initial concentration: NaN
is: P54802
is encoded by: hsa:4669
name: NAGLU
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR GLCt1r
is: SBO:0000185
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
fast: false
name: glucose transport (uniport)
reactant: MODEL1310110039#
product: MODEL1310110039#

metaM hpdcacoa c
boundary condition: false
is: SBO:0000247
has only substance units: false
name: heptadecanoyl coa
constant: false
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: HMDB06497
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_126bb909_93f3_48c6_a3af_98948a0d5174
has only substance units: false
name: PIK3C2A
initial amount: NaN
is encoded by: hsa:5286
constant: false
is: O00443
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM HC01223 m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: CHEBI:57340
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
boundary condition: false
constant: false
type: Species
has only substance units: false

metaR G14T14g
modifier: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
kinetic law: MODEL1310110039#
fast: false
type: Reaction
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM dhlam m
is: CHEBI:17694
constant: false
has only substance units: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
boundary condition: false
is: HMDB00985
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: dihydrolipoamide
type: Species

metaM dgchol c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
boundary condition: false
is: HMDB00637
initial amount: NaN
name: glycochenodeoxycholate
constant: false
is: CHEBI:36252
initial concentration: 1.0

metaR DGK2m
reversible: true
is: SBO:0000176
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
type: Reaction
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
is described by: ECO:0000000

metaR S6TASE19ly
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110039#

metaR r2005
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110039#
product: MODEL1310110039#
reversible: false
fast: false
reactant: MODEL1310110039#
is described by: ECO:0000000

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM 4mop c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00695

http://identifiers.org/biomodels.db/MODEL1310110039#_e61daa69_f688_4c44_a481_a55eaf9a7fc2
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5277
initial concentration: NaN
is: P37287
constant: false
name: PIGA
has only substance units: false
type: Species

metaM maltpt e
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: HMDB01296
constant: false
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C02052
type: Species
initial amount: NaN
has only substance units: false

metaR FORtr
is: SBO:0000185
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: FOR transporter, endoplasmic reticulum
kinetic law: MODEL1310110039#
type: Reaction
fast: false
reversible: true

metaR SUCCCROT
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_0337259f_9f28_441f_94b0_b2aefb0c4b0d
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: CLYBL
boundary condition: true
is encoded by: hsa:171425
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_f637b688_d908_4f89_8e3a_326edee1198d
boundary condition: true
is: B3KQV3
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: PIP4K2C
type: Species
is: SBO:0000252
is encoded by: hsa:79837

metaR PTDCACRNCPT1
reversible: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
name: carnitine fatty-acyl transferase
product: MODEL1310110039#
fast: false

metaM CE0785 m
constant: false
is: CHEBI:57795
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: cis,cis-myristo-5,8-dienoyl-CoA
initial amount: NaN

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaM ump c
is: CHEBI:57865
initial amount: NaN
type: Species
is: HMDB00288
boundary condition: false
is: C00105
constant: false
name: UMP
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247

metaM 3hdeccoa m
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 3-hydroxyhexadecenoylcoa
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d4d058ee_a2a9_48b0_9926_4d9df321b2ac
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:6508
name: SLC4A3
initial amount: NaN

metaR DHFR
type: Reaction
reversible: true
name: dihydrofolate reductase
reactant: MODEL1310110039#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
modifier: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false

metaM ala B e
name: beta-alanine
is: HMDB00056
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
boundary condition: false
is: CHEBI:16958
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_9016bb6e_bf7e_43ec_8481_2dceed9b3985
name: KYNU
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8942
is: Q16719
has only substance units: false
type: Species
initial amount: NaN

metaR r0173
fast: false
product: MODEL1310110039#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.19
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
type: Reaction

metaM dgchol e
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00637
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
is: SBO:0000247
is: CHEBI:36252
has only substance units: false
type: Species

metaM CE1944 c
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
is: CHEBI:36781
type: Species
name: 1-pyrrolinium
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110039#_cc530ef9_8dd6_4d98_ba3c_fa7d311236fb
is encoded by: hsa:H53099
initial concentration: NaN
constant: false
boundary condition: true
name: _H53099_1_m
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaR DOPAtu
kinetic law: MODEL1310110039#
name: Dopamine uniport
reversible: true
fast: false
reactant: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110039#
product: MODEL1310110039#

metaM gln L e
is: HMDB00641
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
initial amount: NaN
type: Species
boundary condition: false
name: L-glutamine

metaR RE1448N
kinetic law: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
product: MODEL1310110039#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE1448

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM pmtcrn r
is: HMDB00222
boundary condition: false
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: L-palmitoylcarnitine
has only substance units: false
initial amount: NaN

metaR THYOXt2
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110039#
name: T4 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_607ab4d2_7396_477f_81fa_1afb6ba379cc
boundary condition: true
is: Q8TB61
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:347734
initial amount: NaN
initial concentration: NaN
name: SLC35B2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e3dd0d10_3f7f_49b3_8ff5_241ff7201fd8
is encoded by: hsa:65985
initial concentration: NaN
name: AACS
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: Q86V21
boundary condition: true

metaR GALASE1ly
modifier: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
is: SBO:0000176
name: beta-galactosidase, lysosomal
reversible: false
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR ABTti
is: SBO:0000185
product: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
name: L-arabinitol transport via passive diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_172bc5e0_b22b_498e_aed9_5175c1b565a1
has only substance units: false
name: DPAGT1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:1798
type: Species

metaR LEUTA
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
name: leucine transaminase
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
product: MODEL1310110039#
fast: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR FACOAL170
fast: false
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reactant: MODEL1310110039#
modifier: MODEL1310110039#

metaM ump e
type: Species
is: HMDB00288
constant: false
name: UMP(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: CHEBI:57865

metaR ASCBt4
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
name: L-ascorbate transport via proton symport
modifier: MODEL1310110039#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#

metaR r1547
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110039#

metaR r2111
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110039#
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true

metaM bilglcur r
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110039#_47cc06eb_5def_4038_822f_ae0f4bfb24cb
constant: false
name: CHKA
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1119
type: Species
initial amount: NaN

metaM frdp x
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00961
type: Species
name: farnesyl pyrophosphate(3-)
has only substance units: false
constant: false
initial concentration: 1.0

metaR AG13T9g
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
fast: false
is: SBO:0000176

metaM 4hexdtetcoa m
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
boundary condition: false
constant: false
initial concentration: 1.0

metaR M13N2Tg
is version of: http://identifiers.org/ec-code/2.4.1.101
kinetic law: MODEL1310110039#
fast: false
type: Reaction
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reactant: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reversible: false
modifier: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176

metaR RE3301C
reversible: true
is: SBO:0000176
product: MODEL1310110039#
is described by: ECO:0000000
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
name: RE3301
kinetic law: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110039#
type: Reaction

metaM thf m
constant: false
boundary condition: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
initial concentration: 1.0
is: C00101
is: CHEBI:57453
type: Species

metaR r2325
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
reversible: true
fast: false

metaM hestratriol e
has only substance units: false
is: SBO:0000247
is: HMDB05896
constant: false
name: 4,17 dihydroxy estradiol
type: Species
initial amount: NaN
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
initial concentration: 1.0

metaR r0718
is version of: http://identifiers.org/ec-code/1.1.1.181
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
reactant: MODEL1310110039#
reversible: false
type: Reaction
modifier: MODEL1310110039#
is described by: ECO:0000000
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaM ksi pre35 g
type: Species
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 35
is: CHEBI:28067
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_7c8525cf_85e2_4d0f_b83e_c65916057731
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4698
is: Q16718
name: NDUFA5
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaM 10fthf m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
initial concentration: 1.0
constant: false
is: HMDB00972
boundary condition: false
type: Species

metaR r2112
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
fast: false
modifier: MODEL1310110039#

metaR r1548
reactant: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
kinetic law: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000

metaR AKR1D
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
kinetic law: MODEL1310110039#
is described by: ECO:0000269
modifier: MODEL1310110039#
type: Reaction
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110039#_6285a749_9f7a_4940_b5c1_b16f3353bbc9
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:1650
boundary condition: true
name: DDOST
type: Species
is: P39656
has only substance units: false

metaR r2326
reactant: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
is: SBO:0000176
reactant: MODEL1310110039#

metaM amp x
initial amount: NaN
is: CHEBI:456215
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
boundary condition: false
name: AMP
has only substance units: false
initial concentration: 1.0
is: HMDB00045
constant: false

metaM acnacngalgbside hs e
boundary condition: false
is: CHEBI:3338
name: disialyl galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN
is: C00036
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00223
type: Species

metaR S4TASE3ly
product: MODEL1310110039#
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaR PYDXNK
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.35
type: Reaction
is: SBO:0000176
modifier: MODEL1310110039#
is described by: ECO:0000269
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110039#
name: pyridoxine kinase
kinetic law: MODEL1310110039#
reversible: false

metaM acetone c
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
has only substance units: false
is: CHEBI:15347
is: HMDB01659
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: acetone
initial concentration: 1.0

metaR r2323
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_4d1e7a04_86c6_497f_95b1_612510e71117
constant: false
boundary condition: true
is encoded by: hsa:6575
is: SBO:0000252
initial concentration: NaN
name: SLC20A2
has only substance units: false
initial amount: NaN
type: Species
is: B2RBR4

metaM hestratriol c
type: Species
constant: false
name: 4,17 dihydroxy estradiol
boundary condition: false
has only substance units: false
is: HMDB05896
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: SBO:0000247

metaM dcmp n
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
initial amount: NaN
is: HMDB01202
initial concentration: 1.0
name: dCMP(2-)
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_9b5d5a1f_5bc8_4e53_a40c_08508932abbf
boundary condition: true
constant: false
name: LDHAL6B
initial amount: NaN
is: SBO:0000252
is: Q9BYZ2
is encoded by: hsa:92483
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_6518bdca_b2f8_47eb_8542_dd6dda67961a
type: Species
name: ST3GAL3
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6487
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_e77ef695_d50b_43e0_bfb2_2966c260dafc
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9Y2D0
is encoded by: hsa:11238
name: CA5B
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR HISSNAT5tc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0716
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
is described by: ECO:0000000

metaM HC01406 m
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: SBO:0000247
type: Species
is: CHEBI:28264
has only substance units: false
constant: false
boundary condition: false

metaR r2110
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_ae217202_e9a3_4d42_bbde_aac41fccbdb8
name: SLC17A1
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: Q14916
is: SBO:0000252
is encoded by: hsa:6568

metaR r1546
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110039#
reversible: true
fast: false

metaR RE3272N
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110039#
name: RE3272
is described by: ECO:0000000
product: MODEL1310110039#
type: Reaction

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaR PPPGOm
is described by: ECO:0000304
product: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.4
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
type: Reaction
is: SBO:0000176
name: protoporphyrinogen oxidase, mitochondrial
kinetic law: MODEL1310110039#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_e36a5bbc_6795_4a5b_b063_188fe59ddb90
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:22305
has only substance units: false
is: SBO:0000252
name: _22305_2_c
boundary condition: true

metaR r2324
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
is described by: ECO:0000000

metaM HC01007 x
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:18102
name: L-Octanoylcarnitine
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaR COAtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110039#
type: Reaction
name: CoA transport in Golgi via diffusion

metaM ha e
type: Species
initial amount: NaN
name: hyaluronan
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
constant: false
is: CHEBI:16336
is: SBO:0000247
has only substance units: false

metaM acnacngalgbside hs g
constant: false
is: SBO:0000247
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:3338
boundary condition: false
initial concentration: 1.0
is: C00036
name: disialyl galactosylgloboside

http://identifiers.org/biomodels.db/MODEL1310110039#_2c14ad80_58b8_44e7_92aa_bc514cfa47f6
is: SBO:0000252
has only substance units: false
is: Q9BZM2
name: PLA2G2F
initial amount: NaN
is encoded by: hsa:64600
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaM met L e
is: SBO:0000247
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
is: CHEBI:16643
initial concentration: 1.0
is: HMDB00696
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_d4c3d54d_755d_4787_8fbf_d999067143d6
is encoded by: hsa:23539
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: O95907
name: SLC16A8
initial concentration: NaN

metaM ppa e
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
name: propionate
type: Species
initial amount: NaN
is: CHEBI:17272
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaR r2321
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_7d6b98ed_c886_4b0b_8be2_99ee95c1d862
is: P31350
name: RRM2
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6241

metaR r1299
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110039#
product: MODEL1310110039#
fast: false
is described by: ECO:0000000
name: Vesicular transport
reversible: false
type: Reaction
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_23c98288_d749_45a2_bae7_fe4ac8d74c5a
is: Q9UJM8
is encoded by: hsa:54363
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: HAO1

metaM eipencoa x
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: 2,5,8,11,14-eicosapentaenoylcoa
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial amount: NaN

metaR PHACCOAGLNAC
type: Reaction
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
is described by: ECO:0000000
reversible: false
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_c2d60216_b923_4d01_9f9c_ef2cea5f4529
boundary condition: true
initial amount: NaN
is encoded by: hsa:NM 013421
is: SBO:0000252
name: _NM_013421_1_e
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR r0714
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_29b9e038_6e1b_404e_b60e_98d31f9545cd
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: B4DX94
name: PGM3
is: SBO:0000252
is encoded by: hsa:5238
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_4a710578_2dc6_499a_997a_ea585d3ec1e8
initial concentration: NaN
name: SLC4A5
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:57835
initial amount: NaN
is: SBO:0000252

metaR ASNGLNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)
is: SBO:0000185
kinetic law: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110039#
type: Reaction

metaR S6TASE3ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
type: Reaction
product: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_80ed3745_c534_4fa5_931e_6fcaefdd4c5f
has part: P48728
is encoded by: hsa:2731
has part: P23378
is: SBO:0000297
type: Species
has part: P23434
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2653
is encoded by: hsa:275
initial amount: NaN
name: DLD:GCSH:GLDC:AMT
boundary condition: true
constant: false

metaR RE1534M
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1534

metaR r1298
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110039#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110039#
name: Vesicular transport
is: SBO:0000185
product: MODEL1310110039#

metaR HGNTOR
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.13.11.5
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110039#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR r2322
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110039#
fast: false
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true

metaR ACRNtm
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
name: O-acetylcarnintine transport into mitochondria via diffusion
type: Reaction
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
product: MODEL1310110039#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110039#_ca9cec84_a755_4df7_9d7c_acd9de601306
initial amount: NaN
is encoded by: hsa:57665
is: Q9HBH5
has only substance units: false
constant: false
name: RDH14
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR CYTDtm
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110039#
fast: false
product: MODEL1310110039#
reversible: true
type: Reaction
name: cytidine facilated transport in mitochondria

metaR r1544
reactant: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM pcrn x
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0
is: HMDB00824
type: Species
name: propionyl-carnitine
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaM q10 m
is: CHEBI:46245
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01072
name: ubiquinone-10

metaM 3ddecdicoa x
is: HMDB03952
is: SBO:0000247
type: Species
name: 3,6-dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: C05280

http://identifiers.org/biomodels.db/MODEL1310110039#_c545bcc8_539d_44e0_8aa7_44c32097403f
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:518
is: SBO:0000252
name: ATP5G3
type: Species

metaR RE0935E
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: true
type: Reaction
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR COAtm
fast: false
kinetic law: MODEL1310110039#
name: CoA transporter
reversible: true
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is described by: ECO:0000269
reactant: MODEL1310110039#
is: SBO:0000185
modifier: MODEL1310110039#
type: Reaction
product: MODEL1310110039#

metaM met L c
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
is: SBO:0000247
is: CHEBI:16643
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00696
constant: false
boundary condition: false
initial amount: NaN

metaM ppa c
constant: false
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
initial concentration: 1.0
is: HMDB00237
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17272
initial amount: NaN

metaM dcsptn1coa m
constant: false
boundary condition: false
is: HMDB06513
is: C16173
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR C4CRNCPT2
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM lnlccoa c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064
name: linoleic coenzyme A
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
type: Species
boundary condition: false
constant: false

metaM lneldccrn c
type: Species
boundary condition: false
is: HMDB06461
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Linoelaidyl carnitine
constant: false
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+

http://identifiers.org/biomodels.db/MODEL1310110039#_f2349ea0_3c20_436f_aed3_29fd0d15eee5
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: HPGDS
is: O60760
initial concentration: NaN
is encoded by: hsa:27306
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_25540bcb_4529_4f54_826b_7ba748562dfb
boundary condition: true
has only substance units: false
name: HIBADH
is: P31937
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:11112
is: SBO:0000252

metaR EX c81crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_f5d78c3d_04d5_47ac_90a7_0966b701e1ab
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:N63787
boundary condition: true
name: _N63787_1_c

http://identifiers.org/biomodels.db/MODEL1310110039#_1ef6a173_230d_488a_bcfd_7b12c5512719
name: PIK3R3
initial amount: NaN
boundary condition: true
is: Q92569
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:8503
constant: false
is: SBO:0000252

metaR PPCDC
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
name: phosphopantothenoylcysteine decarboxylase
is described by: ECO:0000269
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110039#
type: Reaction
reversible: false
fast: false
is: SBO:0000176

metaM ala B c
initial concentration: 1.0
is: CHEBI:16958
name: beta-alanine
has only substance units: false
is: SBO:0000247
is: HMDB00056
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
initial amount: NaN
boundary condition: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR COAtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
type: Reaction
product: MODEL1310110039#
is: SBO:0000185
name: CoA transport in lysosome via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reversible: true
fast: false
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_de8f6978_6b44_4977_922b_2db2a362209b
initial amount: NaN
has only substance units: false
is: P54886
is encoded by: hsa:5832
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: ALDH18A1
type: Species

metaM trdrd c
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: C00342
is: CHEBI:15967
initial amount: NaN
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a46ae8ac_f475_4e67_8972_68d6d94cd42b
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q7KZA3
name: FECH
is encoded by: hsa:2235
type: Species
constant: false

metaR r2320
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR C81CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM c226coa x
constant: false
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
name: cervonyl coenzyme A
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a26527ab_7095_4d48_b498_1a17b71806f1
is: SBO:0000252
name: ACOT2
boundary condition: true
initial concentration: NaN
type: Species
is: P49753
is encoded by: hsa:10965
initial amount: NaN
has only substance units: false
constant: false

metaM hexdectecoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: HMDB02288
initial amount: NaN
type: Species
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
is: SBO:0000247
has only substance units: false

metaR HEXDIACTD
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaR C101CRNe
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR GPIDA2er
type: Reaction
is: SBO:0000176
reactant: MODEL1310110039#
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110039#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
fast: false

metaR DCK2n
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
is described by: ECO:0000269
product: MODEL1310110039#
fast: false
name: Deoxycytidine kinase, nuclear (UTP)

metaM glc D c
name: D-glucose
constant: false
has only substance units: false
is: HMDB00122
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: CHEBI:4167

http://identifiers.org/biomodels.db/MODEL1310110039#_820313b4_81c3_4e88_a388_846332da5097
type: Species
has only substance units: false
is: Q9P019
name: PHPT1
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29085
initial concentration: NaN
boundary condition: true

metaM 10fthf c
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
initial amount: NaN
is: HMDB00972
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
type: Species
has only substance units: false
initial concentration: 1.0

metaM c101crn e
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: decenoyl carnitine
initial concentration: 1.0
constant: false
boundary condition: false

metaR FADH2tx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
name: FADH2 transporter, peroxisomal
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
is: SBO:0000185
reversible: true

metaM lneldccrn m
name: Linoelaidyl carnitine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06461
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+

metaM pcrn m
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738
name: propionyl-carnitine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
constant: false
is: HMDB00824
initial amount: NaN

metaM ksi deg23 l
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 23
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species

metaM sph1p c
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
boundary condition: false
is: CHEBI:57939
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
constant: false
is: HMDB01383
initial concentration: 1.0
initial amount: NaN

metaM digalsgalside hs c
type: Species
name: Digalactosylceramidesulfate
boundary condition: false
is: http://identifiers.org/pubchem.compound/8384
initial concentration: 1.0
constant: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: C06127
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM sph1p e
is: SBO:0000247
is: CHEBI:57939
has only substance units: false
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
constant: false
is: HMDB01383
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_b4b6cf3b_aa19_45eb_a169_156903bdc565
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:953
type: Species
constant: false
is: Q86VV3
has only substance units: false
initial concentration: NaN
name: ENTPD1

metaR r0604
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
reversible: false
product: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000176
type: Reaction
fast: false

metaR GCCcm
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is: SBO:0000176
modifier: MODEL1310110039#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110039#_7b360032_975c_431a_9253_2ac3d9380374
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53919
name: SLCO1C1
initial amount: NaN
type: Species
is: Q5JPA4
boundary condition: true

metaR DNDPt27m
name: dCDP transport via dTDP antiport
modifier: MODEL1310110039#
reversible: false
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaM cdpea c
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
boundary condition: false
is: CHEBI:57876
initial concentration: 1.0
constant: false
name: cdpea[c]
is: HMDB01564
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM hexdectecoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 2,4,7,10-hexadecatetraenoylcoa
is: HMDB02288
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaM crm hs g
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: N-acylsphingosine
initial amount: NaN
is: CHEBI:52639
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110039#_3c949af5_2dec_46f0_abd7_9eb55bd0924c
initial concentration: NaN
name: SOD1
constant: false
is: P00441
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6647

metaR r1540
kinetic law: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
fast: false
product: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false

metaR COAtn
product: MODEL1310110039#
fast: false
type: Reaction
kinetic law: MODEL1310110039#
reversible: true
name: coenzyme A transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110039#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_ddeb7c7b_c714_48db_8b3b_699b71ccae40
name: IDS
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3423
is: SBO:0000252
type: Species
is: B4DGD7
boundary condition: true
constant: false

metaM glc D e
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
boundary condition: false
name: D-glucose
is: HMDB00122
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:4167
has only substance units: false

metaR P5CRxm
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000304
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110039#
name: pyrroline-5-carboxylate reductase (m)
reversible: false
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR HESTRATRIOLte
is: SBO:0000185
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport
reversible: true
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#

metaM c101crn c
notes: FORMULA: C17H31NO4 CHARGE: 0
has only substance units: false
is: HMDB13205
name: decenoyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false

metaR ABTArm
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
is described by: ECO:0000269
fast: false
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
type: Reaction
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
product: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_0f7eaffa_0ecc_45d0_83e0_f69def4656ca
name: _AU149534_1_c
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AU149534
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR r0603
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
fast: false
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12

http://identifiers.org/biomodels.db/MODEL1310110039#_41185199_6cd7_4399_a3fd_035cd8fda5b2
name: CMA1
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:1215
is: SBO:0000252
initial concentration: NaN
is: Q4FEB3

http://identifiers.org/biomodels.db/MODEL1310110039#_dee7231a_0961_4e02_8f0a_33f5f761506f
type: Species
boundary condition: true
is encoded by: hsa:10587
name: TXNRD2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_98abbda8_4561_4cc4_b301_010757df063e
has only substance units: false
type: Species
name: RRM1
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6240
is: P23921

metaM lgnccoa x
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
name: lignocericyl coenzyme A
type: Species
is: HMDB06526
constant: false

metaR RE1523M
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110039#
fast: false
reversible: true
reactant: MODEL1310110039#
is described by: ECO:0000000
name: RE1523
is: SBO:0000176
modifier: MODEL1310110039#
type: Reaction

metaR FAOXC16180m
is described by: ECO:0000269
fast: false
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
reversible: false
reactant: MODEL1310110039#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110039#

metaR B3GALT5g
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110039#
name: Beta-1,3-galactosyltransferase 5
kinetic law: MODEL1310110039#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_09234676_83a8_4a19_804f_1c4fc17b5473
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:NM 013421
name: _NM_013421_1_m
is: SBO:0000252
has only substance units: false
type: Species

metaR RE1898C
kinetic law: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
is: SBO:0000176
name: RE1898

http://identifiers.org/biomodels.db/MODEL1310110039#_9694395a_084b_46f5_be3e_b2007a0c419c
is encoded by: hsa:411
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P15848
type: Species
initial amount: NaN
name: ARSB

http://identifiers.org/biomodels.db/MODEL1310110039#_0c877309_67a4_4315_8a19_a86ccbc06a90
has only substance units: false
initial concentration: NaN
is: P53597
constant: false
boundary condition: true
is encoded by: hsa:8802
initial amount: NaN
is: SBO:0000252
name: SUCLG1
type: Species

metaM btcoa x
type: Species
is: C00136
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
name: Butanoyl-CoA
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01088

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaM adpcoa c
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB04047
initial concentration: 1.0
name: adipoylcoa
is: C14143

metaM ump r
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
name: UMP
is: HMDB00288
initial concentration: 1.0
initial amount: NaN
constant: false

metaR DNDPt40m
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reversible: false
is described by: ECO:0000269
name: dUTP transport via dADP antiport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM HC01376 m
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: S-(2-Methylbutanoyl)-dihydrolipoamide
boundary condition: false
constant: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
is: CHEBI:28692
initial concentration: 1.0

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110039#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is: SBO:0000185
name: coenzyme A transport, peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110039#_1e1360f5_0450_49c8_bcba_8bdfcbbb3a4d
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:85365
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ALG2
type: Species

metaM tetdec2coa c
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
boundary condition: false
name: tetradecadienoylcoa
is: HMDB02014
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_a3c18006_961f_4b65_89b9_1ea6733714e9
constant: false
type: Species
is: SBO:0000252
name: BDH1
boundary condition: true
is encoded by: hsa:622
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM c226coa m
is: C16169
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false
is: SBO:0000247
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM btn c
name: Biotin
initial concentration: 1.0
has only substance units: false
is: HMDB00030
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
type: Species
is: CHEBI:3420
boundary condition: false
initial amount: NaN
is: C00120
constant: false

metaR S6T10g
fast: false
reactant: MODEL1310110039#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction

metaM dcsptn1coa x
initial concentration: 1.0
initial amount: NaN
constant: false
is: C16173
has only substance units: false
is: HMDB06513
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
type: Species
boundary condition: false

metaM ppa m
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
name: propionate
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00237
is: CHEBI:17272

metaR r2329
type: Reaction
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
reversible: true
product: MODEL1310110039#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM lnlccoa m
boundary condition: false
is: HMDB01064
type: Species
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: linoleic coenzyme A
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

metaM clpndcoa x
constant: false
is: http://identifiers.org/pubchem.compound/47205476
name: clupanodonyl CoA
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: C16166
is: HMDB06267

metaR r1291
product: MODEL1310110039#
reactant: MODEL1310110039#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction

metaR r2434
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110039#
fast: false
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110039#_b74f2166_bd9d_48b6_af02_983177daa91a
name: SLC26A6
initial concentration: NaN
is encoded by: hsa:65010
is: Q9Y3Y1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_40b8fb5e_0e71_41f6_acf9_4d1402735b30
is: E5KSL6
name: DGUOK
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1716
initial amount: NaN
type: Species

metaR NTD2e
product: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
is: SBO:0000176
name: 5'-nucleotidase (UMP), extracellular
type: Reaction
kinetic law: MODEL1310110039#
is described by: ECO:0000134
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110039#_b7c747ee_848e_405e_88db_6f378e0b14ac
type: Species
initial concentration: NaN
has only substance units: false
is: O60733
is: SBO:0000252
boundary condition: true
name: PLA2G6
is encoded by: hsa:8398
constant: false
initial amount: NaN

metaR RTOTAL2FATPc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaR FAOXC204C205x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110039#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is: SBO:0000176
modifier: MODEL1310110039#
name: RE1573
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_7f0a3bf1_1e9a_4a87_b3da_279ca83910d0
name: DCK
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P27707
is encoded by: hsa:1633
boundary condition: true

metaR COAtr
reversible: true
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110039#
name: COA transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110039#_5b2b2058_65cf_4de4_aed0_d9f0082cec01
is: Q6IBA0
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFS5
is encoded by: hsa:4725
initial amount: NaN
constant: false

metaM thp2c c
is: HMDB12130
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: 1-piperideine-6-carboxylate
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
type: Species
is: CHEBI:16987

http://identifiers.org/biomodels.db/MODEL1310110039#_6320fd80_76e5_4954_ba6b_7b9536e33387
is: O43677
boundary condition: true
has only substance units: false
is encoded by: hsa:4717
initial concentration: NaN
type: Species
constant: false
name: NDUFC1
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110039#_ab0fb928_7f22_4a8a_86a8_aefc821ea1c9
name: AK4
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:205
initial amount: NaN

metaM thf c
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB01846
is: CHEBI:57453
initial concentration: 1.0
is: C00101
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate

metaM HC01602 c
initial amount: NaN
is: C00234
is: SBO:0000247
constant: false
has only substance units: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaM btn e
is: SBO:0000247
name: Biotin
is: HMDB00030
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: CHEBI:3420
initial amount: NaN
boundary condition: false
is: C00120
constant: false

metaR 4HGLSDm
is described by: ECO:0000212
reversible: true
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
fast: false
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD

metaM crm hs c
name: N-acylsphingosine
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false
boundary condition: false
is: CHEBI:52639
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR C8DCc
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR r2327
fast: false
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
reversible: true
is: SBO:0000185
product: MODEL1310110039#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM damp c
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: dAMP(2-)
is: HMDB00905
has only substance units: false
is: CHEBI:58245
boundary condition: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial concentration: 1.0

metaM HC01496 m
name: 2-Amino-3-oxoadipate
is: SBO:0000247
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:28095
has only substance units: false

metaM m2emgacpail hs r
constant: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: C00080
initial amount: NaN
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_73069ec2_8902_455d_bd2c_5e5f57d4b987
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: SLC26A6
is encoded by: hsa:65010
is: Q9NQU1
has only substance units: false
is: SBO:0000252

metaM ksi deg27 l
initial amount: NaN
name: keratan sulfate I, degradation product 27
type: Species
is: HMDB00143
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936
has only substance units: false
constant: false

metaM octe5coa x
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 5-octenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110039#_758f3d38_5605_4cbe_8e90_19f4b0149114
is encoded by: hsa:6817
initial concentration: NaN
name: SULT1A1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_ec0c2be9_dde3_489f_8cdc_d5588254a2ff
constant: false
type: Species
has part: O95497
is encoded by: hsa:55350
boundary condition: true
name: VNN3:VNN2:VNN1
has part: A8K7W0
is encoded by: hsa:8876
is encoded by: hsa:8875
has only substance units: false
is: SBO:0000297
initial amount: NaN
initial concentration: NaN

metaM 4hexdtetcoa x
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
constant: false
has only substance units: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_d8257bdc_1e4a_4adc_901d_b6ddad0e78da
constant: false
boundary condition: true
is encoded by: hsa:23428
initial amount: NaN
has part: Q86U05
has only substance units: false
is: SBO:0000297
initial concentration: NaN
type: Species
name: SLC7A8:SLC3A2

metaR HACD1m
is described by: ECO:0000134
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110039#

metaR AG13T13g
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
modifier: MODEL1310110039#
reversible: false
product: MODEL1310110039#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110039#_b7608678_236f_4d12_85d8_bc95e96a659f
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54344
constant: false
initial amount: NaN
is: Q86TM7
initial concentration: NaN
name: DPM3
boundary condition: true
type: Species

metaR r1292
reversible: true
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110039#
type: Reaction
is: SBO:0000185
product: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false

metaM crm hs e
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
constant: false
name: N-acylsphingosine
is: SBO:0000247
has only substance units: false
is: CHEBI:52639
initial concentration: 1.0
initial amount: NaN

metaR EX c101crn
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaR r2328
is: SBO:0000185
type: Reaction
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110039#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_23552914_cb6d_4547_b186_82a06d94b590
is: O15427
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9123
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC16A3
type: Species

metaR CYTK10
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
name: cytidylate kinase (CMP,dGTP)
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR P5CRm
fast: false
reversible: false
is described by: ECO:0000304
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
name: pyrroline-5-carboxylate reductase (m)
product: MODEL1310110039#
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR PGLer
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
reactant: MODEL1310110039#
name: 6-phosphogluconolactonase, endoplasmic reticulum
is described by: ECO:0000269
fast: false
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#

metaM strdnc c
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
constant: false
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM trdrd m
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15967
has only substance units: false
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaR RETNt
name: retinoic acid transport
kinetic law: MODEL1310110039#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
reversible: true
product: MODEL1310110039#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_bb58001e_c0e7_4e39_9970_ae4620ccf4ee
constant: false
initial amount: NaN
has only substance units: false
name: NDUFA2
is: O43678
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4695
is: SBO:0000252

metaR MMMm
reactant: MODEL1310110039#
product: MODEL1310110039#
fast: false
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV

metaR PIt8
modifier: MODEL1310110039#
reversible: true
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is: SBO:0000185
fast: false
product: MODEL1310110039#
type: Reaction
is described by: ECO:0000006
kinetic law: MODEL1310110039#
name: phosphate transport in/out via Na+ symporter

metaR CYSGLNNaEx
kinetic law: MODEL1310110039#
product: MODEL1310110039#
name: L-cysteine/L-glutamine Na-dependent exchange (Cys-L in)
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110039#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110039#_9b32f250_ed92_442c_aba2_8f0ddd76ccd9
is: SBO:0000252
name: B3GNT1
initial amount: NaN
is: O43505
is encoded by: hsa:11041
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaM estradiol r
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: HMDB00151
is: CHEBI:16469
is: SBO:0000247
constant: false
name: estradiol
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0560
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#
is described by: ECO:0000000
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
product: MODEL1310110039#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
reversible: false
is: SBO:0000176

metaR S6TASE20ly
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110039#

metaR TTDCPT1
name: carnitine O-palmitoyltransferase
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110039#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110039#
type: Reaction
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM udp c
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: CHEBI:58223
boundary condition: false
type: Species
is: HMDB00295
is: C00015
name: UDP

http://identifiers.org/biomodels.db/MODEL1310110039#_77a1ee34_3dea_4d08_ba29_fc5b9203d4d4
is: Q9UHW9
initial amount: NaN
is encoded by: hsa:9990
constant: false
initial concentration: NaN
type: Species
name: SLC12A6
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110039#_bcd2a329_ec87_4231_adbf_f2ef0da11a09
has only substance units: false
is encoded by: hsa:2879
type: Species
boundary condition: true
is: P36969
name: GPX4
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR FAOXC18280m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reversible: false
modifier: MODEL1310110039#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110039#
is: SBO:0000176
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110039#

metaR GALASE14ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110039#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110039#_f5c50fe7_cf30_4650_b3f8_0fbe5ad15ce8
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: O75355
initial concentration: NaN
has only substance units: false
is encoded by: hsa:956
name: ENTPD3

http://identifiers.org/biomodels.db/MODEL1310110039#_4167730e_f811_4861_b53f_d852a31d6fa6
has only substance units: false
boundary condition: true
is: Q9H6R3
constant: false
is encoded by: hsa:79611
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: ACSS3

http://identifiers.org/biomodels.db/MODEL1310110039#_34b91687_1092_4dab_b48d_b3f1793d5432
initial amount: NaN
constant: false
name: PLCL1
is: SBO:0000252
is: Q15111
type: Species
is encoded by: hsa:5334
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM c226coa c
name: cervonyl coenzyme A
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
boundary condition: false
is: SBO:0000247
type: Species
is: C16169

metaR FAOXC2442246x
fast: false
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110039#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR CYTK12
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
name: cytidylate kinase (dCMP,dCTP)
fast: false
is described by: ECO:0000269
reversible: true

metaM xol7aone r
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
is: HMDB01993
constant: false
initial concentration: 1.0
is: CHEBI:17899

metaM L2aadp c
is: HMDB00510
constant: false
type: Species
is: CHEBI:58672
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: L-2-aminoadipate(1-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR TTDCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
fast: false
is: SBO:0000176
product: MODEL1310110039#
kinetic law: MODEL1310110039#
modifier: MODEL1310110039#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM strdnc e
constant: false
initial concentration: 1.0
name: stearidonic acid C18:4, n-3
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205608
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
has only substance units: false
boundary condition: false
is: HMDB06547
initial amount: NaN
is: C16300

http://identifiers.org/biomodels.db/MODEL1310110039#_c8774e94_d92a_4245_8735_2abde36d7786
is encoded by: hsa:55967
boundary condition: true
is: F8VQS7
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: NDUFA12

metaM ivcrn c
type: Species
initial concentration: 1.0
is: HMDB00688
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H23NO4 CHARGE: 0
constant: false
boundary condition: false
name: isovaleryl carnitine
has only substance units: false

metaM gluala e
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/6503
is: HMDB06248
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: C03740
name: 5-L-Glutamyl-L-alanine

metaR DM sTn antigen g
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM sTn antigen(g)
type: Reaction

metaR CYTK11
modifier: MODEL1310110039#
reversible: true
fast: false
product: MODEL1310110039#
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM ksi deg16 l
is: HMDB01354
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
name: keratan sulfate I, degradation product 16
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM udp e
is: SBO:0000247
initial amount: NaN
is: CHEBI:58223
name: UDP(3-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
boundary condition: false
is: HMDB00295
constant: false

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: CHEBI:16947
type: Species
constant: false
has only substance units: false
is: HMDB00094
name: citrate(3-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR NACHEX9ly
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110039#
fast: false
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction

metaM dlnlcgcrn c
is: HMDB01311
type: Species
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110039#_ab5e9fa5_a45d_42cc_bbc9_46a5b3bd5c93
name: SLC2A12
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: Q8TD20
boundary condition: true
is encoded by: hsa:154091
initial concentration: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR G14T15g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110039#
product: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110039#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110039#

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_06890ab8_722b_4225_b60b_e6cfdd1fb2ae
constant: false
is: SBO:0000252
name: FOLR1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:2348
initial concentration: NaN

metaR TRPO2
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
product: MODEL1310110039#
modifier: MODEL1310110039#
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.11
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
is described by: ECO:0000269

metaR NACHEX5ly
kinetic law: MODEL1310110039#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_1f3299b9_07d9_4e52_b82a_8375d8a5501c
boundary condition: true
has only substance units: false
is encoded by: hsa:AV717590
type: Species
is: SBO:0000252
constant: false
name: _AV717590_1_c
initial amount: NaN
initial concentration: NaN

metaR KYNATESYN
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is described by: ECO:0000000
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_bc19184b_381c_40b2_89bc_91f4e3f648c2
constant: false
initial concentration: NaN
name: PRDX2
boundary condition: true
is encoded by: hsa:7001
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: P32119

metaR RE2954C
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
modifier: MODEL1310110039#
is: SBO:0000176
name: RE2954
type: Reaction
reversible: true

metaM ksi pre22 g
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 22
has only substance units: false
is: CHEBI:58053
type: Species
is: HMDB00175
boundary condition: false
is: C00130
constant: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
initial concentration: 1.0

metaM ivcrn e
initial amount: NaN
is: HMDB00688
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H23NO4 CHARGE: 0
name: isovaleryl carnitine
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110039#_1f8f05db_5fb5_444c_b94a_3fcb1a8f56ff
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:X63359
initial concentration: NaN
constant: false
name: _X63359_1_c
boundary condition: true
initial amount: NaN

metaM cit c
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
is: C00158
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Citrate
is: CHEBI:16947
constant: false

metaM digalsgalside hs g
constant: false
is: C06127
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/8384
name: Digalactosylceramidesulfate
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110039#_4dc970d8_78ba_4bd9_9fcf_0bfd3a386892
name: BCKDHB
constant: false
boundary condition: true
is: P21953
is encoded by: hsa:594
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
reversible: true
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false

metaM idp n
has only substance units: false
boundary condition: false
name: IDP(3-)
is: HMDB03335
initial concentration: 1.0
is: CHEBI:58280
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaM xu5p D c
boundary condition: false
is: HMDB00868
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57737
has only substance units: false
name: D-xylulose 5-phosphate(2-)
type: Species

metaR ADSS
is version of: http://identifiers.org/ec-code/6.3.4.4
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
fast: false
product: MODEL1310110039#
reversible: false
modifier: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110039#
name: adenylosuccinate synthase

http://identifiers.org/biomodels.db/MODEL1310110039#_1a19bf7e_d27e_42fa_adda_ec51ed61dff9
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3030
is: E9KL44
name: HADHA
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaM acetone m
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
type: Species
boundary condition: false
is: HMDB01659
is: CHEBI:15347
initial amount: NaN
is: SBO:0000247
name: acetone
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110039#_8ed0d129_cf4d_430b_adcc_7e2ad20a2304
initial amount: NaN
is encoded by: hsa:8760
initial concentration: NaN
is: O95674
name: CDS2
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR C40CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM tag hs c
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
type: Species
is: SBO:0000247
name: triglyceride
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR CYSALANaEx
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)

metaM lnlccoa r
boundary condition: false
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: linoleic coenzyme A
initial amount: NaN
type: Species
constant: false

metaR r0456
kinetic law: MODEL1310110039#
product: MODEL1310110039#
is: SBO:0000176
modifier: MODEL1310110039#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reactant: MODEL1310110039#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
reversible: false

metaR FAOXC205C184x
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaM HC01007 c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C15H29NO4 CHARGE: 0 INCHI: InChI=1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m0/s1 EHMN_ABBREVIATION: C02838
type: Species
has only substance units: false
is: CHEBI:18102
is: SBO:0000247
name: L-Octanoylcarnitine

metaM hs deg8 l
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: heparan sulfate, degradation product 8
is: HMDB00127
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: CHEBI:15748

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR RE3004M
modifier: MODEL1310110039#
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110039#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110039#
name: RE3004
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110039#_d47219f6_d297_4263_8fb5_6e3cbbbb62eb
is encoded by: hsa:377841
type: Species
constant: false
name: ENTPD8
initial amount: NaN
is: Q5MY95
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM man1p c
initial concentration: 1.0
is: HMDB06330
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
name: D-Mannose 1-phosphate
has only substance units: false
boundary condition: false
is: CHEBI:35374

metaM s2l2n2m2mn l
initial amount: NaN
is: HMDB00573
constant: false
boundary condition: false
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: CHEBI:30825
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)

http://identifiers.org/biomodels.db/MODEL1310110039#_d36c9d19_ce29_4a48_aeee_efcbee20e868
boundary condition: true
name: DGKH
is: Q86XP1
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:160851
constant: false
is: SBO:0000252

metaM digalsgalside hs e
boundary condition: false
initial amount: NaN
name: Digalactosylceramidesulfate
has only substance units: false
type: Species
is: C06127
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C30H55NO15SFULLRCO CHARGE: -1 EHMN_ABBREVIATION: C06127
is: http://identifiers.org/pubchem.compound/8384

metaR r2109
modifier: MODEL1310110039#
product: MODEL1310110039#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110039#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110039#
fast: false

metaM HC01415 m
name: (2E)-Octenoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27537
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110039#_426a22b7_74cd_4a20_9ba6_a509377fb886
is: SBO:0000252
is: Q308M7
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5169
constant: false
name: ENPP3

http://identifiers.org/biomodels.db/MODEL1310110039#_0304ac9f_68fd_4dc7_94e9_e51fc9ccf07e
initial amount: NaN
is encoded by: hsa:11136
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: P82251
boundary condition: true
name: SLC7A9

metaM ksii core4 pre6 g
notes: FORMULA: C69H111N6O51SX CHARGE: -2
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
constant: false
initial concentration: 1.0

metaM prostgh2 c
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57405
name: prostaglandin H2(1-)
is: HMDB01381

metaR PIt7
reactant: MODEL1310110039#
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
product: MODEL1310110039#
type: Reaction
kinetic law: MODEL1310110039#
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110039#_5b887dad_146a_475d_b43f_894a048a74cb
has only substance units: false
name: PKM2
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5315
constant: false

metaR RIBt
fast: false
is described by: ECO:0000000
reactant: MODEL1310110039#
product: MODEL1310110039#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110039#
name: ribose transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction

metaM L2aadp6sa c
is: HMDB01263
boundary condition: false
is: SBO:0000247
name: L-allysine
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
constant: false
has only substance units: false
type: Species
is: CHEBI:17917
initial concentration: 1.0

metaM g3m8masn r
boundary condition: false
is: C05873
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C88H147N2O70X CHARGE: 0
type: Species
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR ITCOALm
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110039#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110039#
is described by: ECO:0000212
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110039#
fast: false

metaR CRNtim
is: SBO:0000185
name: L-carnitine transport out of mitochondria via diffusion
modifier: MODEL1310110039#
reactant: MODEL1310110039#
fast: false
reversible: false
product: MODEL1310110039#
is described by: ECO:0000269
kinetic law: MODEL1310110039#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction

metaM CE0693 m
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
initial amount: NaN
is: SBO:0000247
is: HMDB11123

metaR HDCAter
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110039#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110039#
name: palmitate ER export
product: MODEL1310110039#
is described by: ECO:0000000

metaR r2019
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110039#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110039#
is described by: ECO:0000000
reactant: MODEL1310110039#
kinetic law: MODEL1310110039#

metaR RETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
fast: false
name: Retinol transport via faciliated diffusion
reversible: false
product: MODEL1310110039#
is: SBO:0000185
kinetic law: MODEL1310110039#
type: Reaction
reactant: MODEL1310110039#

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_8fc2b406_806e_430c_8f84_f42f5809359d
is encoded by: hsa:2678
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: GGT1
type: Species
constant: false
is: P19440

metaR DRPA
reversible: false
reactant: MODEL1310110039#
is: SBO:0000176
kinetic law: MODEL1310110039#
product: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110039#_356ed07e_16cb_4539_968a_96ea61894831
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5151
boundary condition: true
name: PDE8A
type: Species
has only substance units: false
initial amount: NaN

metaR C51CPT1
kinetic law: MODEL1310110039#
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_3a4fac5d_4b59_4a8f_a07f_1c3544b44d8b
constant: false
is encoded by: hsa:4712
type: Species
has only substance units: false
name: NDUFB6
initial concentration: NaN
boundary condition: true
is: O95139
is: SBO:0000252
initial amount: NaN

metaR r2330
is: SBO:0000185
fast: false
reactant: MODEL1310110039#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110039#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110039#
is described by: ECO:0000000

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_e92b1500_f35a_46e2_820b_f9a283e1acd9
is encoded by: hsa:2194
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: P49327
boundary condition: true
name: FASN
initial concentration: NaN

metaR r2108
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110039#
reactant: MODEL1310110039#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110039#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110039#

http://identifiers.org/biomodels.db/MODEL1310110039#_a03cd978_ebcc_4b93_b76c_40fdc7c52761
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: GALNT14
is: Q96FL9
has only substance units: false
is encoded by: hsa:79623

metaM tag hs e
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17855
initial concentration: 1.0
boundary condition: false
constant: false
name: triglyceride
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0

metaR FAS160COA
reactant: MODEL1310110039#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reversible: false
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110039#
product: MODEL1310110039#

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110039#
reactant: MODEL1310110039#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110039#_cb822dea_31a8_42d9_ae9f_c659e6047a1c
is encoded by: hsa:5167
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: P22413
name: ENPP1

metaR FAS100COA
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110039#
is: SBO:0000176
name: fatty acyl-CoA synthase (n-C10:0CoA)
modifier: MODEL1310110039#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110039#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110039#
type: Reaction

metaM nadp c
is: SBO:0000247
is: C00006
has only substance units: false
is: HMDB00217
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
name: Nicotinamide adenine dinucleotide phosphate
type: Species
initial amount: NaN
is: CHEBI:58349