metaR r2030
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110038#

metaM 4hexdtetcoa x
constant: false
name: 4,7,10,13-hexadecatetraenoylcoa
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB02288

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM hdd2crn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: trans-Hexadec-2-enoyl carnitine
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06317
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_807710a9_33c6_4a15_b14e_267a5f224eab
boundary condition: true
is: P00352
is: SBO:0000252
type: Species
constant: false
name: ALDH1A1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:216
initial amount: NaN

metaR r2315
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110038#_3492a3fa_413a_4f81_b89a_5f01b404c4c2
name: GSR
constant: false
is encoded by: hsa:2936
type: Species
initial concentration: NaN
is: P00390
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0002
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
reversible: true
is: SBO:0000185
name: Active transport

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaM gm3 hs g
initial amount: NaN
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: CHEBI:60065
boundary condition: false
has only substance units: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM n2m2nmasn l
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: C04946
has only substance units: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN

metaR TRIODTHYt2
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
name: T3 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is: SBO:0000185

metaM cspg e e
boundary condition: false
is: HMDB00300
is: SBO:0000247
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: C00106
is: CHEBI:17568
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_f54d6df7_8bb2_4669_b635_4404f63d6866
is: O60658
is encoded by: hsa:5151
has only substance units: false
name: PDE8A
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR RE3218C
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.2
reactant: MODEL1310110038#
fast: false
type: Reaction
product: MODEL1310110038#
name: RE3218
is: SBO:0000176

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR r2031
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000185

metaM galgluside hs g
has only substance units: false
type: Species
is: C00015
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247
boundary condition: false
is: CHEBI:58223
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00295

metaM octa e
name: octanoate (n-C8:0)
is: HMDB00482
is: C06423
type: Species
notes: FORMULA: C8H15O2 CHARGE: -1
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:25646

metaR r2316
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110038#

metaR C10OHc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM dmnoncrn m
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
name: 4,8 dimethylnonanoyl carnitine
initial amount: NaN
is: HMDB06202
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_dabe1ad7_797c_413b_968d_145e3298ff2b
has only substance units: false
is encoded by: hsa:211
is: P13196
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: ALAS1

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_4c9cb774_cde3_439d_86d3_99c000104791
boundary condition: true
name: PIK3CA
is: P42336
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:5290
is: SBO:0000252
type: Species

metaM dcsptn1crn c
initial concentration: 1.0
is: SBO:0000247
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species

metaR FBA
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000134
product: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
name: fructose-bisphosphate aldolase
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is version of: http://identifiers.org/ec-code/4.1.2.13

http://identifiers.org/biomodels.db/MODEL1310110038#_f69834c2_0f19_47ed_9b49_65768a032228
name: SORD
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:6652
has only substance units: false
is: Q00796

http://identifiers.org/biomodels.db/MODEL1310110038#_d0b6ce17_c20f_442c_901c_708df1ba487b
is: P22392
initial amount: NaN
constant: false
name: NME2
has only substance units: false
type: Species
is encoded by: hsa:4831
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM crvnc e
has only substance units: false
is: HMDB02183
type: Species
name: cervonic acid, C22:6 n-3
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1
constant: false
is: CHEBI:36005
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_bcb52502_4790_4c60_b2cf_ead8cc654066
constant: false
initial concentration: NaN
type: Species
name: ST3GAL3
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6487

metaR r2313
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110038#
is: SBO:0000185
type: Reaction

metaM na1 r
type: Species
has only substance units: false
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
name: sodium(1+)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29101

metaM glyphe e
name: Glycylphenylalanine
boundary condition: false
has only substance units: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97415
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR GLXtm
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reversible: true
name: glyoxylate transport, mitochondrial
fast: false
type: Reaction
product: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_bc31ed5b_7438_4d85_85a4_21b55d871f50
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI990637_1_x
initial concentration: NaN
is encoded by: hsa:AI990637
constant: false

metaR NACHEXA18ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110038#
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
reactant: MODEL1310110038#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_714bc027_ae4c_4323_9765_0ee4aa1cf805
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: O43678
name: NDUFA2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4695

metaM ksi pre30 g
name: keratan sulfate I biosynthesis, precursor 30
type: Species
boundary condition: false
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58053
is: SBO:0000247
constant: false
has only substance units: false
is: C00130
notes: FORMULA: C219H350N15O184S9X CHARGE: -10

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_fd1ebd98_d565_4a48_8c29_080109c501a7
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ATP5J
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:522

http://identifiers.org/biomodels.db/MODEL1310110038#_53b47eaa_fb48_457f_b301_bc9b1dd03f75
initial concentration: NaN
is: Q14435
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2591
type: Species
name: GALNT3

metaM Tn antigen l
has only substance units: false
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: C04383
name: Tn antigen
initial concentration: 1.0

metaM udpacgal c
type: Species
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
is: SBO:0000247
is: CHEBI:57847
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9783a346_98f1_4623_b30b_e87be96d249f
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: ACAD11
constant: false
boundary condition: true
is: Q709F0
is encoded by: hsa:84129
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_b852aa58_bad2_4959_b473_87f1c80817a6
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:29920
initial concentration: NaN
name: PYCR2
has only substance units: false
boundary condition: true
type: Species
is: Q96C36

metaM ser L e
initial concentration: 1.0
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
initial amount: NaN
is: HMDB00187
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17115
constant: false

metaM arach e
boundary condition: false
is: SBO:0000247
name: arachidate
type: Species
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
constant: false
initial amount: NaN
is: CHEBI:32360
has only substance units: false

metaM idp e
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
is: HMDB03335
name: IDP(3-)
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58280
type: Species

metaR RBFK
is: SBO:0000176
modifier: MODEL1310110038#
reversible: false
name: riboflavin kinase
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.26
type: Reaction
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000269

metaM glgchlo e
notes: FORMULA: C1200026H2200043NO1100006 CHARGE: 0
is: SBO:0000247
is: HMDB00725
type: Species
has only substance units: false
constant: false
name: beta glucan-glycocholate complex
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM lald L c
has only substance units: false
is: CHEBI:18041
is: HMDB03052
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
is: SBO:0000247
name: (S)-lactaldehyde
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_04ec31b9_d6e1_4c13_ba1a_3b582b344153
initial concentration: NaN
is: P05091
is: SBO:0000252
name: ALDH2
initial amount: NaN
is encoded by: hsa:217
has only substance units: false
boundary condition: true
constant: false
type: Species

metaR r2314
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_2fa836df_ad3a_44c1_ad14_3e9ca3d0d0d5
has only substance units: false
name: RPE
type: Species
is: Q96AT9
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6120
constant: false
initial amount: NaN

metaR FACOAL40im
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.2
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
name: fatty-acid--CoA ligase (butanoate), mitochondrial
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (116285.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: PMID:11470804,PMID:3297476 NOTES:JLR changed EC from 6.2.1.3 (long chain fatty-acyl CoA ligase) to 6.2.1.2 (butyrate-CoA ligase) - NCD

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110038#
is described by: ECO:0000134
product: MODEL1310110038#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110038#
type: Reaction

metaR DESAT18 6
product: MODEL1310110038#
fast: false
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110038#

metaR r0119
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
is: SBO:0000176
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110038#

metaR r2311
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaM glyphe c
notes: FORMULA: C11H14N2O3 CHARGE: 0
boundary condition: false
constant: false
name: Glycylphenylalanine
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97415

metaR NDPK2n
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_920d0e03_7a6f_467d_ab76_05e4164c1143
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM 4hphac e
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:48999
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
name: 4-hydroxyphenylacetate
is: SBO:0000247
is: HMDB00020

http://identifiers.org/biomodels.db/MODEL1310110038#_4037dded_fa3d_4cd7_a5d8_5c47c3828ac2
is encoded by: hsa:8395
boundary condition: true
is: SBO:0000252
name: PIP5K1B
initial concentration: NaN
constant: false
is: O14986
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_8fba5a09_444d_431c_84e0_afc9c5b35503
type: Species
has part: P07195
has only substance units: false
has part: P00338
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3939
is encoded by: hsa:3945
name: LDHA:LDHB
constant: false
is: SBO:0000297
boundary condition: true

metaR RE2649C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
name: RE2649
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#

metaR MG2er
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110038#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

metaM adrncoa x
is: SBO:0000247
is: C16170
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
has only substance units: false
constant: false
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_3a715618_a562_40af_b408_1ca958a1c2f8
is encoded by: hsa:5334
is: SBO:0000252
is: Q15111
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: PLCL1

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM HC01410 m
name: (2E)-Hexenoyl-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
type: Species
is: CHEBI:28706
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_0c3ef136_4b61_4d89_a505_9ccfeded0789
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: DUOX1
is encoded by: hsa:53905
boundary condition: true
is: Q9NRD9

metaR r2312
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
type: Reaction

metaM arach c
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
type: Species
boundary condition: false
constant: false
has only substance units: false
name: arachidate
is: SBO:0000247
initial amount: NaN
is: HMDB02212
is: CHEBI:32360

metaR ADSL2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
name: adenylosuccinate lyase
reversible: false
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110038#_98d067f7_be63_409c_93ed_4cd75690bb2e
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1375
is: B7Z5T8
initial amount: NaN
boundary condition: true
name: CPT1B
type: Species

metaM m6mpdol U r
boundary condition: false
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:37635
constant: false
type: Species
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM 2dpmhobq m
is: HMDB06484
boundary condition: false
type: Species
constant: false
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: CHEBI:50771
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_cd44e716_e639_43f9_9afb_92d894b9ce48
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: GALNT10
is: Q86SR1
type: Species
boundary condition: true
is encoded by: hsa:55568
constant: false
is: SBO:0000252

metaM dolichol L c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C1080H1768O10 CHARGE: 0
has only substance units: false
is: CHEBI:16091
name: Dolichol, human liver homolog
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_eba3e60f_d604_45b7_a042_f20d818a4c40
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:4514
name: COX3
boundary condition: true
has only substance units: false
initial amount: NaN
is: P00414

metaR DESAT18 8
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
is: SBO:0000176
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
is described by: ECO:0000269

metaR PIACGT
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: phosphatidylinositol N-acetylglucosaminyltransferase
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is version of: http://identifiers.org/ec-code/2.4.1.198
reversible: false
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_b7355c73_ca8e_480d_86f9_c1d5e38a90e8
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _AI640625_1_c
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI640625

metaR r0818
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reversible: false
fast: false
name: Transport reaction
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000

metaR ADSL1
name: adenylosuccinate lyase
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.3.2.2
is: SBO:0000176
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000269

metaR FACOAL204
reversible: true
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
fast: false
name: fatty-acid--CoA ligase
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM ttetddcoa m
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB02288
constant: false
has only substance units: false

metaR CYTDtm
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
type: Reaction
product: MODEL1310110038#
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110038#
name: cytidine facilated transport in mitochondria
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185

metaM udpacgal g
is: CHEBI:57847
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
constant: false
is: HMDB00304
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM pail4p hs c
constant: false
initial amount: NaN
type: Species
is: CHEBI:58178
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

http://identifiers.org/biomodels.db/MODEL1310110038#_9309cea6_8639_40ec_9f29_eccc375253ab
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NDUFB5
is: O43674
type: Species
is encoded by: hsa:4711
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_326723a7_5bf0_48fb_9924_537cd3e48fe3
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: LDHC
is encoded by: hsa:3948
initial amount: NaN
is: SBO:0000252
constant: false

metaR ACGAMK
is: SBO:0000176
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: N-acetylglucosamine kinase
type: Reaction

metaM octa c
constant: false
name: octanoate (n-C8:0)
type: Species
is: SBO:0000247
notes: FORMULA: C8H15O2 CHARGE: -1
initial concentration: 1.0
is: HMDB00482
is: CHEBI:25646
initial amount: NaN
boundary condition: false
is: C06423
has only substance units: false

metaR r2310
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR GLXtp
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, peroxisomal
reversible: true
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#

metaR P5CDm
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
fast: false

metaM CE4790 m
initial amount: NaN
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
constant: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM 4hphac c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
constant: false
initial amount: NaN
type: Species
name: 4-hydroxyphenylacetate
is: HMDB00020
boundary condition: false
is: CHEBI:48999
is: SBO:0000247

metaR NDPK2m
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
kinetic law: MODEL1310110038#
is described by: ECO:0000254
reactant: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction

metaR FACOAL203
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110038#
fast: false
reversible: true

metaR GULN3D
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
name: L-gulonate 3-dehydrogenase
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is: SBO:0000176

metaR RE3347C
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
name: RE3347
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true

metaR C3DCe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR CYTDtn
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110038#
name: cytidine transport in nucleus
kinetic law: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_1679c265_ecbe_4650_9ad3_06fc4d5cc73e
is: SBO:0000252
constant: false
is: Q9UN76
has only substance units: false
name: SLC6A14
is encoded by: hsa:11254
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR GULLACter
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
reversible: false
reactant: MODEL1310110038#
name: gulonolactone endoplasmic reticular transport
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110038#

metaR FAOXC102m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_592f3a17_745e_412b_8c29_ae860aab5344
initial amount: NaN
is encoded by: hsa:5338
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PLD2
type: Species
constant: false
is: SBO:0000252
is: O14939

metaR r0559
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110038#
fast: false
reversible: true

metaR COQ5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
reversible: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Ubiquinone biosynthesis methyltransferase COQ5
fast: false
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000

metaR OCCOAtm
reversible: false
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
name: Octanoyl-CoA transport, diffusion
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
is described by: ECO:0000000

metaR PHCDm
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.1.12
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
reversible: false
type: Reaction
fast: false
product: MODEL1310110038#

metaR SADT
kinetic law: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110038#
name: sulfate adenylyltransferase

metaM 2dodtricoa m
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C05279
type: Species
initial amount: NaN
has only substance units: false
is: HMDB11123
name: 2,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaR GUAt
is: SBO:0000185
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Guanine transport
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
type: Reaction
reversible: true
reactant: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#

metaR DUTPDPn
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.6.1.23
reversible: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear
type: Reaction
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176

metaR N3Tg
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110038#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.122
is: SBO:0000176
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
fast: false
modifier: MODEL1310110038#

metaR AGPAT1
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/2.3.1.51
reactant: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.15
reversible: false

metaR r1088
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
reversible: true
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_ea7af2b0_3dec_4381_951a_4515eed9a866
initial concentration: NaN
initial amount: NaN
name: DHCR24
has only substance units: false
boundary condition: true
is encoded by: hsa:1718
is: SBO:0000252
type: Species
is: Q15392
constant: false

metaM n2m2nmasn e
type: Species
is: C04946
constant: false
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110038#_0ed74fa2_3d6c_40f3_8432_92a11c1200a3
constant: false
initial concentration: NaN
initial amount: NaN
is: Q15758
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6510
name: SLC1A5

metaR PDX5PO
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
name: pyridoxine 5'-phosphate oxidase
reversible: true
product: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#

metaR RE2998M
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: false
name: RE2998
kinetic law: MODEL1310110038#

metaR RE3004M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3004

http://identifiers.org/biomodels.db/MODEL1310110038#_c75de4ec_03e9_413a_ad16_2c85e26821d7
is: Q86XP1
is encoded by: hsa:160851
has only substance units: false
initial amount: NaN
name: DGKH
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaM dmnoncrn c
has only substance units: false
type: Species
is: HMDB06202
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
name: 4,8-dimethylnonanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110038#_6cc8760a_66b1_44b4_bbc2_71d9e896648c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3613
initial concentration: NaN
type: Species
name: IMPA2
has only substance units: false
is: O14732
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_c1a6d972_967c_40f2_b7fb_562c93891e79
initial concentration: NaN
is: A8K092
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: ATP5A1
is: SBO:0000252
is encoded by: hsa:498
type: Species

metaM ipdp x
boundary condition: false
initial concentration: 1.0
constant: false
name: isopentenyl diphosphate(3-)
is: SBO:0000247
is: HMDB01347
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:128769
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129

http://identifiers.org/biomodels.db/MODEL1310110038#_bd56f18d_c5ea_4034_8664_bb129a2e261e
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:645
has only substance units: false
is: P30043
constant: false
name: BLVRB
initial concentration: NaN
type: Species

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM hexdectecoa m
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_abe6e7ac_6880_4c1a_9c26_2443e83ea7a8
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:4731
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: P56181
name: NDUFV3

http://identifiers.org/biomodels.db/MODEL1310110038#_f5518c90_c2b8_4ac1_bf56_4466890d0e22
has only substance units: false
is encoded by: hsa:124935
initial amount: NaN
boundary condition: true
name: SLC43A2
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: Q8N370

metaM CE0233 c
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
initial amount: NaN
is: HMDB01993
boundary condition: false
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,27-triol
is: CHEBI:17899

metaR CSBPASEly
kinetic law: MODEL1310110038#
reversible: false
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
reactant: MODEL1310110038#

metaR OCOAT1m
is described by: ECO:0000269
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.8.3.5
type: Reaction
name: 3-oxoacid CoA-transferase
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
product: MODEL1310110038#
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110038#

metaM ser L c
is: CHEBI:17115
name: L-serine
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00187
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
initial concentration: 1.0

metaM na1 c
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:4541
name: Sodium
is: HMDB00588
is: C01330

http://identifiers.org/biomodels.db/MODEL1310110038#_6fd5531d_7f1d_4b34_96f5_38d4cbdf3bd9
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q6PXP3
boundary condition: true
has only substance units: false
initial amount: NaN
name: SLC2A7
is encoded by: hsa:155184

metaR FTHFL
reversible: true
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
name: Formate-tetrahydrofolate ligase
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000134
fast: false

metaR r2319
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
product: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000

metaR XYLtly
name: Xylose efflux from lysosome
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaR RE0452M
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
name: RE0452

metaM crvnc c
type: Species
name: cervonic acid, C22:6 n-3
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
has only substance units: false
is: CHEBI:36005
is: HMDB02183
initial concentration: 1.0

metaM taur x
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: taurine
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
constant: false
is: CHEBI:15891
is: SBO:0000247
is: HMDB00251
type: Species

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM CE1936 e
is: SBO:0000247
is: CHEBI:36781
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: spermine dialdehyde
boundary condition: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_d556f873_fef7_4159_9eeb_2f1ba800710b
initial amount: NaN
name: PYCR1
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5831
initial concentration: NaN
type: Species
has only substance units: false
is: A6NFM2

metaR 2AMACHYD
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
is described by: ECO:0000000
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
name: 2-Aminoacrylate hydrolysis
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#

metaM T antigen g
is: CHEBI:22783
notes: FORMULA: C14H24NO10X CHARGE: 0
initial amount: NaN
has only substance units: false
name: T antigen (core 1)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_36d857a6_647e_46fc_befb_71b0ee90de1d
has only substance units: false
is: Q9H2X9
initial concentration: NaN
boundary condition: true
type: Species
name: SLC12A5
initial amount: NaN
constant: false
is encoded by: hsa:57468
is: SBO:0000252

metaM 4hpro LT m
boundary condition: false
name: trans-4-hydroxy-L-proline
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: HMDB00725
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_05ddc3fd_eb10_46f7_bd05_273e555762dc
constant: false
type: Species
is: SBO:0000252
name: NAGA
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P17050
is encoded by: hsa:4668

metaR ADKd
product: MODEL1310110038#
modifier: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110038#
name: adenylate kinase (d form)
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)

http://identifiers.org/biomodels.db/MODEL1310110038#_3814e5b8_a553_4655_ae91_c161ac76faac
boundary condition: true
type: Species
constant: false
is: Q96CD2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:60490
has only substance units: false
is: SBO:0000252
name: PPCDC

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaM idp c
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB03335
initial concentration: 1.0
name: IDP(3-)
boundary condition: false
is: CHEBI:58280
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cf11a81e_11db_4ca0_960e_dab9fa4ef263
name: CHST1
initial amount: NaN
boundary condition: true
is: O43916
has only substance units: false
type: Species
is encoded by: hsa:8534
initial concentration: NaN
constant: false
is: SBO:0000252

metaM f6p c
has only substance units: false
boundary condition: false
is: CHEBI:57579
name: D-Fructose 6-phosphate
is: HMDB00124
is: http://identifiers.org/pubchem.compound/3385
initial concentration: 1.0
is: C00085
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaM CE0713 m
boundary condition: false
name: 3-oxolinoleoyl-CoA
type: Species
is: HMDB02329
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: SBO:0000247
initial amount: NaN
is: CHEBI:30623
has only substance units: false
constant: false
initial concentration: 1.0

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM na1 e
is: HMDB00588
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1
is: C01330
is: CHEBI:4541
is: SBO:0000247
type: Species
constant: false
name: Sodium
boundary condition: false
has only substance units: false

metaM uri m
name: uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
is: CHEBI:16704
boundary condition: false
initial amount: NaN
is: HMDB00296
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaR r0113
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_4a818e69_be80_43dd_95ba_f5045f0a66c1
is encoded by: hsa:51727
initial concentration: NaN
name: CMPK1
is: B2R6S5
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaR r2317
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
reversible: true
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_f5afe0a8_25bd_4f1e_99e1_357237a37129
name: FAH
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: P16930
is encoded by: hsa:2184

http://identifiers.org/biomodels.db/MODEL1310110038#_b4eaae19_f6d0_4e61_8f68_2baed0f9491b
constant: false
initial amount: NaN
is: P28330
is encoded by: hsa:33
initial concentration: NaN
type: Species
name: ACADL
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM alpa hs c
initial amount: NaN
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
boundary condition: false
constant: false
name: lysophosphatidic acid
is: SBO:0000247
type: Species
is: CHEBI:52288
initial concentration: 1.0
has only substance units: false

metaR FAOXC5C3x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaR ITCOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.5
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000212
fast: false
product: MODEL1310110038#

metaR OCDCEAtr
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110038#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_b242477a_60bd_4492_965d_86fed213da55
is encoded by: hsa:8394
initial concentration: NaN
is: Q99755
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: PIP5K1A
constant: false
has only substance units: false

metaR r2318
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110038#
fast: false

metaM uri n
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00296
boundary condition: false
name: uridine

http://identifiers.org/biomodels.db/MODEL1310110038#_24a6d861_ffc0_422d_8fce_f187e91e6321
constant: false
name: GCK
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2645
initial amount: NaN
type: Species
is: P35557
is: SBO:0000252

metaR ELAIDCRNt
kinetic law: MODEL1310110038#
reversible: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110038#

metaR sink decdicoa LPAREN c RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Sink for 2,6-dodecadienoylcoa(c)
type: Reaction

metaR r0009
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110038#_e7520803_0544_48bd_88ce_96fc64dcee77
is encoded by: hsa:570
constant: false
is: Q14032
type: Species
boundary condition: true
name: BAAT
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR OCD11CRNCACT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR ECOAH12m
product: MODEL1310110038#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_32a93689_81eb_4d22_af0a_66b7172ee050
is encoded by: hsa:57127
has only substance units: false
is: Q9H310
constant: false
name: RHBG
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR DHFR
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110038#
modifier: MODEL1310110038#
name: dihydrofolate reductase
kinetic law: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000254
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_bf6e7b44_51a8_4f31_bff1_30c8052e9e2a
name: NIT2
initial amount: NaN
is: Q9NQR4
is: SBO:0000252
is encoded by: hsa:56954
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_04699135_6a0c_438b_b770_d0198cdd05ea
has only substance units: false
is: SBO:0000252
type: Species
name: DGAT1
initial amount: NaN
is encoded by: hsa:8694
boundary condition: true
is: O75907
initial concentration: NaN
constant: false

metaR UREAt5
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
is: SBO:0000185
name: urea, water cotransport
reactant: MODEL1310110038#
is described by: ECO:0000269

metaM dhap x
constant: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
type: Species
is: CHEBI:57642
is: HMDB01473
name: Dihydroxyacetone phosphate
is: C00111
has only substance units: false
initial concentration: 1.0

metaM eicostetcrn c
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
is: CHEBI:57312
type: Species
constant: false
initial amount: NaN
name: Eicosatetranoyl carnitine
is: HMDB01356

http://identifiers.org/biomodels.db/MODEL1310110038#_cf5e77a1_faf7_4b64_a4a2_47ec9c0b356d
has only substance units: false
is encoded by: hsa:23533
type: Species
initial concentration: NaN
is: SBO:0000252
name: PIK3R5
is: Q8WYR1
initial amount: NaN
boundary condition: true
constant: false

metaM m6masnC g
is: CHEBI:50570
constant: false
is: SBO:0000247
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: HMDB06529
initial concentration: 1.0
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110038#
type: Reaction

metaM hexde7coa x
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: HMDB02288
name: 7-hexadecenoylcoa
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaR r1799
name: Y+LAT2 Utilized transport
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
fast: false

metaM C04849 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
is: CHEBI:57449
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

metaR NTD2m
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110038#
type: Reaction
name: 5'-nucleotidase (UMP), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110038#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110038#

metaM cs b deg2 l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5
initial amount: NaN
constant: false
is: CHEBI:16953
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
type: Species
boundary condition: false
is: HMDB00812

metaR GTHRDt
fast: false
type: Reaction
reactant: MODEL1310110038#
reversible: true
name: Glutathione transport into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is: SBO:0000185
product: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_bd8265cb_6d18_4890_9f62_0f289a8d95da
is: Q9BW60
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: ELOVL1
type: Species
initial concentration: NaN
is encoded by: hsa:64834
is: SBO:0000252

metaM ptdca c
constant: false
is: http://identifiers.org/pubchem.compound/22169126
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00826
initial concentration: 1.0
boundary condition: false
name: pentadecanoate
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

metaR C80CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b59ea6d4_ecb3_40ce_aa73_39384a3515c9
is encoded by: hsa:1557
initial amount: NaN
has only substance units: false
is: P33261
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: CYP2C19
constant: false

metaM pram c
constant: false
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN
is: HMDB01128
initial concentration: 1.0
type: Species
is: CHEBI:58681
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: C03090
boundary condition: false

metaM 2dr5p c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01031
constant: false
has only substance units: false
type: Species
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: CHEBI:57651
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

http://identifiers.org/biomodels.db/MODEL1310110038#_ad419030_c20c_4bda_b925_c8c21c702d90
type: Species
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000252
name: DPM2
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_ed2db9d3_dec4_475f_9f83_dd11027e9f22
type: Species
name: ATP5G3
initial amount: NaN
is encoded by: hsa:518
is: P48201
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a320d878_6180_4901_aaa0_4f4bf611f012
is: P00390
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:2936
has only substance units: false
boundary condition: true
name: GSR
initial amount: NaN

metaR r1687
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e728a4bc_82a3_4a99_81eb_ca5eda0bd885
name: PIGO
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84720
constant: false

metaR HOCTDACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM prgstrn e
boundary condition: false
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
initial amount: NaN
is: SBO:0000247
is: HMDB01830
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:17026
name: progesterone

metaR r0450
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_2d636b08_dbae_43c4_9984_3e1d9fc36018
initial amount: NaN
is: Q6UVY6
is encoded by: hsa:26002
has only substance units: false
name: MOXD1
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_693ca03d_6f2f_444d_9ca7_6c1ce57ec4a9
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27010
has only substance units: false
is: SBO:0000252
constant: false
is: F5GZG6
name: TPK1
boundary condition: true

metaR BGLUGCHe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_103364a2_4c92_4c53_8a8a_eff36021064a
is: Q86TM7
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54344
constant: false
is: SBO:0000252
name: DPM3
type: Species

metaM vacc e
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
type: Species
name: trans-vaccenate
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR HIBDm
reversible: true
reactant: MODEL1310110038#
is: SBO:0000176
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.31
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM

metaR RE1534M
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1534
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110038#

metaR BAAT1x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
type: Reaction
name: bile acid Coenzyme A: amino acid N-acyltransferase
is: SBO:0000176
reversible: false
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000269
product: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_433dd844_f217_4058_b1e3_6ca81d271753
has only substance units: false
is encoded by: hsa:4694
is: Q6IBB5
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: NDUFA1

metaR GALASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110038#
name: beta-galactosidase, lysosomal
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaR Uritm
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
name: uridine facilated transport in mitochondria
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#

metaM tetdec2crn c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: tetradecadienoyl carnitine
is: HMDB02014
notes: FORMULA: C21H37NO4 CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0

metaR r1090
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaM acetone m
has only substance units: false
name: acetone
initial concentration: 1.0
initial amount: NaN
is: HMDB01659
constant: false
boundary condition: false
is: CHEBI:15347
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_3ba03573_294c_4754_aa33_211db5558750
initial amount: NaN
constant: false
is: B4DK61
name: ACOX1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:51
has only substance units: false

metaM prgstrn c
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB01830
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H30O2 CHARGE: 0 INCHI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C00410
name: progesterone
is: CHEBI:17026

metaR Uritn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
name: uridine transport in nucleus

metaR r1381
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: true
type: Reaction
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5

metaR LYStn
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
name: L-lysine transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110038#

metaR r0954
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
name: MCT 1 Transport reaction
reversible: true

metaR DMHPTCRNte
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
name: 2,6 dimethylheptanoyl carnitine transport
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ

metaM creat e
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: creatine
is: HMDB00064
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919

metaR MALTt1r
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: true
name: maltose transport (uniport)
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
is: SBO:0000185

metaR r1682
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
reversible: false
fast: false
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110038#

metaR RE3079X
reactant: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110038#
reversible: true
name: RE3079
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_580e24b9_d0cf_460c_8c04_ba0f2431d878
boundary condition: true
name: ACSS2
is encoded by: hsa:55902
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q5QPH3
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_34a836cc_6c2a_462e_b798_f18752818ac0
is encoded by: hsa:4700
initial concentration: NaN
is: P56556
constant: false
initial amount: NaN
is: SBO:0000252
name: NDUFA6
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0c098745_b602_44d1_9dec_bb5939c23a4c
is: SBO:0000252
is: A5JJ20
name: SLC4A4
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:8671

metaM prostgi2 e
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: prostaglandin I2(1-)
is: HMDB01335
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: CHEBI:57403

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b1e4d7e5_b962_46a6_80db_aaf750668ca6
has only substance units: false
is: O75912
type: Species
name: DGKI
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:9162
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_84cae9f0_cd1b_45f6_b07b_ea80891310be
is: Q9UGQ3
constant: false
has only substance units: false
name: SLC2A6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11182
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_226f2ec3_7fdb_4099_b4ba_eb80235ca1ae
is encoded by: hsa:271
boundary condition: true
name: AMPD2
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: Q01433

metaM tetdec2crn e
notes: FORMULA: C21H37NO4 CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB05066
name: tetradecadienoyl carnitine
constant: false

metaM ser D e
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
boundary condition: false
is: CHEBI:16523
constant: false
type: Species
has only substance units: false
is: SBO:0000247
name: D-serine
is: HMDB03406
initial concentration: 1.0

metaR PROSTGI2t
reversible: true
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110038#
name: Prostaglandin I2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction

metaM fald e
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16842
is: HMDB01426
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
initial concentration: 1.0

metaM dolichol L r
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1080H1768O10 CHARGE: 0
constant: false
type: Species
initial amount: NaN
is: CHEBI:16091
name: Dolichol, human liver homolog
initial concentration: 1.0

metaR LYStm
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
name: Lysine mitochondrial transport via ornithine carrier
modifier: MODEL1310110038#
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110038#

metaR r0707
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.168
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
reversible: true
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_60633f0f_3d86_477d_9963_bedb91f184f7
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PLCB1
type: Species
is: SBO:0000252
is encoded by: hsa:23236
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6147f04e_434e_4c45_bb9b_ebefd2737c80
is: Q16678
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1545
constant: false
is: SBO:0000252
name: CYP1B1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_84bcd51d_32fc_4830_b416_3fd4b109f9ad
initial concentration: NaN
name: ACP1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:52
constant: false
has only substance units: false
is: B5MCC7
type: Species
boundary condition: true

metaR r1683
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110038#
reversible: false
fast: false
modifier: MODEL1310110038#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000

metaM fgam c
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C04376
is: HMDB01308
type: Species

metaM ksi pre5 g
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 5

metaR PROSTGH2t
product: MODEL1310110038#
name: Prostaglandin H2 transport
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
kinetic law: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false

metaR RE2659R
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: RE2659
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
fast: false

metaR r2194
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0706
is version of: http://identifiers.org/ec-code/1.3.99.10
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
reversible: false
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110038#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
reactant: MODEL1310110038#

metaR XYLTD Dr
reversible: true
is: SBO:0000176
reactant: MODEL1310110038#
name: xylitol dehydrogenase (D-xyulose-forming)
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110038#

metaR SPH1Pte
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: sph1p transport
fast: false
is: SBO:0000185
type: Reaction
reversible: true

metaR OCTAt
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
fast: false
name: Octanoate transport via diffusion
reactant: MODEL1310110038#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_6a8c38fa_7c97_4186_92f8_6746def6580f
is encoded by: hsa:6649
initial concentration: NaN
name: SOD3
is: P08294
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

metaM c81coa c
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
type: Species
is: C05276
is: HMDB03949
has only substance units: false
name: octenoylcoa
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_d199b450_f298_431e_b73c_0b03d21cb9e6
boundary condition: true
is encoded by: hsa:5136
is: SBO:0000252
is: P54750
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: PDE1A

metaR XOL27OHtm
name: 27 hydroxy cholesterol transport
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d008387c_30fe_4097_ba33_9e259b7434be
is: SBO:0000297
constant: false
boundary condition: true
type: Species
name: DLAT:DLD:PDHA1:PDHB:PDHX
initial concentration: NaN
is encoded by: hsa:5160
has only substance units: false
has part: P08559
initial amount: NaN

metaM ser D c
is: CHEBI:16523
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: HMDB03406
boundary condition: false
name: D-serine
has only substance units: false
initial concentration: 1.0

metaR TXASr
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.5
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
product: MODEL1310110038#
name: Thromboxane-A synthase
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_eef274a2_2439_4280_aeff_74b53f9508ba
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: TM7SF2
is: SBO:0000252
is: O76062
boundary condition: true
is encoded by: hsa:7108

metaR DHPM1
kinetic law: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.2.2
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
name: dihydropyrimidinase (5,6-dihydrouracil)
reversible: false
modifier: MODEL1310110038#
type: Reaction

metaR r1384
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_95e6684d_9abc_41a0_bbda_6f87edbc2c00
is: Q9BZX2
is: SBO:0000252
is encoded by: hsa:7371
constant: false
type: Species
name: UCK2
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR PPCOAOm
reversible: false
modifier: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reactant: MODEL1310110038#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false

metaR RE1709N
is: SBO:0000176
is described by: ECO:0000000
name: RE1709
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_35f72039_0e2b_4bf2_91fc_f339d62ee466
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: B7Z792
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4720
name: NDUFS2

metaR r2193
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#

metaM creat c
has only substance units: false
name: creatine
is: HMDB00064
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: SBO:0000247

metaM ptdcacrn m
has only substance units: false
is: CHEBI:18303
initial amount: NaN
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: pendtadenoyl carnitine

metaR FAOXC101m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR COQ6m
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
reversible: false
product: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
type: Reaction
fast: false
is: SBO:0000176
name: Ubiquinone biosynthesis monooxgenase COQ6

metaM ptdca e
is: http://identifiers.org/pubchem.compound/22169126
initial amount: NaN
constant: false
name: pentadecanoate
type: Species
boundary condition: false
is: HMDB00826
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
has only substance units: false

metaR TYRt
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false
kinetic law: MODEL1310110038#
name: L-tyrosine transport
is described by: ECO:0000269
reactant: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#

metaR FAOXC161C161OHm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR r1681
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110038#
reversible: false
name: Y+LAT2 Utilized transport

metaR HMGLm
is described by: ECO:0000134
fast: false
reactant: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.3.4
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
product: MODEL1310110038#
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_dfadaeaf_0b1e_47e3_a3cb_9a947513fb99
is encoded by: hsa:AA576959
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AA576959_1_c
type: Species
boundary condition: true

metaM octd11ecoa c
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
is: SBO:0000247
name: 11-octadecenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110038#_6c787471_9b88_4e39_9d22_2bbea7fdddbd
constant: false
name: SDHD
is: O14521
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6392
initial amount: NaN

metaM ksi pre27 g
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 27
initial concentration: 1.0
is: C00130
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9

http://identifiers.org/biomodels.db/MODEL1310110038#_43c6042b_0bd4_4c36_9e2d_a1b8664e47f6
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:3098
constant: false
initial concentration: NaN
has only substance units: false
name: HK1
is: SBO:0000252
is: P19367

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR FK
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
name: Fucokinase
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.52
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
fast: false
reversible: false
kinetic law: MODEL1310110038#

metaR DECDPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110038#_610a97ce_097a_48b4_927a_d82c15ad22d8
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: P23786
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1376
name: CPT2
initial amount: NaN

metaR r0817
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110038#_afccd4ca_cf6a_4778_bb7e_c4daffa3f275
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: Q96Q11
has only substance units: false
is encoded by: hsa:51095
name: TRNT1

metaR GTHOm
modifier: MODEL1310110038#
name: glutathione oxidoreductase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110038#
is described by: ECO:0000254
product: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110038#
type: Reaction

metaM prostgi2 r
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0
is: CHEBI:57403
boundary condition: false
is: HMDB01335
has only substance units: false

metaM ksi pre11 g
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 11
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM met L e
type: Species
initial amount: NaN
is: CHEBI:16643
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00696

metaM met L c
boundary condition: false
name: L-methionine
initial amount: NaN
type: Species
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
is: HMDB00696
is: CHEBI:16643
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
is: HMDB06807
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial concentration: 1.0
is: CHEBI:58528
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_26c63b54_8f35_4bca_a3e8_634992a2e9e9
constant: false
name: PHPT1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:29085
is: SBO:0000252
is: Q9P019
has only substance units: false
boundary condition: true
type: Species

metaR PROt2r
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: L-proline reversible transport via proton symport
fast: false
modifier: MODEL1310110038#

metaM lthstrl r
name: 5alpha-cholest-7-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:17168
boundary condition: false
constant: false
is: HMDB01170
is: SBO:0000247
type: Species

metaR NRPPHRtu
modifier: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
kinetic law: MODEL1310110038#
fast: false
type: Reaction
name: Norepinephrine uniport

http://identifiers.org/biomodels.db/MODEL1310110038#_0f8968b0_6975_47de_b67b_e7f345652fcb
initial amount: NaN
is: Q7Z364
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: PDE1B
is encoded by: hsa:5153
type: Species
has only substance units: false

metaM idp n
constant: false
is: CHEBI:58280
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
name: IDP(3-)
is: HMDB03335
initial concentration: 1.0

metaR MMMm
product: MODEL1310110038#
is described by: ECO:0000269
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.99.2
name: methylmalonyl-CoA mutase
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
reversible: true
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#

metaR RE1709C
product: MODEL1310110038#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000000
name: RE1709
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_e35086bf_855d_4ebc_a7ac_6849c657f730
boundary condition: true
has only substance units: false
name: MYO5B
is encoded by: hsa:4645
type: Species
constant: false
is: SBO:0000252
is: Q9H6Y6
initial concentration: NaN
initial amount: NaN

metaM taur c
is: HMDB00251
initial concentration: 1.0
is: SBO:0000247
name: Taurine
type: Species
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
is: CHEBI:3544
is: C00245
boundary condition: false

metaR PUNP1
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Adenosine)

http://identifiers.org/biomodels.db/MODEL1310110038#_19067e6e_1eae_4ae7_acd6_bba5ba0982b0
name: ALDH1A2
boundary condition: true
is: O94788
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:8854
has only substance units: false
is: SBO:0000252

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_058e0e82_e117_41ea_b6bc_1392a7af326d
is encoded by: hsa:8659
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: ALDH4A1
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9457b72a_d158_4249_b945_0a5684322ee8
name: MAOB
is: P27338
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4129
constant: false
initial amount: NaN
boundary condition: true

metaM leuleu c
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
name: Leucylleucine
type: Species
notes: FORMULA: C12H24N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/94244
initial concentration: 1.0
boundary condition: false

metaM CE5788 e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
has only substance units: false
boundary condition: false
is: HMDB02710
is: CHEBI:27485
type: Species
constant: false
is: SBO:0000247
name: kinetensin 1-7

metaM acetone c
is: CHEBI:15347
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01659
has only substance units: false
boundary condition: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_30553138_e749_4750_af10_ea109926bafe
is: SBO:0000252
is encoded by: hsa:6818
initial concentration: NaN
boundary condition: true
type: Species
name: SULT1A3
is: Q1ET61
has only substance units: false
initial amount: NaN
constant: false

metaM 4hexdtetcoa m
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: 4,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
is: HMDB02288

metaM nicrnt c
type: Species
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: CHEBI:57502
has only substance units: false
is: HMDB01132
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Nicotinate D-ribonucleotide
is: SBO:0000247

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_37aec34f_3eb7_4c8a_bdcb_97304b6a0319
is: D3DWC4
constant: false
is encoded by: hsa:259230
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: SGMS1

metaR SPMS
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000269
name: spermidine synthase
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.16
is: SBO:0000176

metaR ACONT
type: Reaction
modifier: MODEL1310110038#
reversible: true
is described by: ECO:0000134
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110038#
name: aconitase
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
is: SBO:0000176

metaR RE1810M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
type: Reaction
fast: false
name: RE1810
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR TRPHYDRO2
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.16.4
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
is: SBO:0000176
fast: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is described by: ECO:0000269

metaR PUNP2
is described by: ECO:0000269
fast: false
reactant: MODEL1310110038#
type: Reaction
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyadenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM xu5p D c
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: CHEBI:57737
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00868
name: D-xylulose 5-phosphate(2-)
boundary condition: false

metaR FAOXC101x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaM lnlccoa c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
is: SBO:0000247
type: Species

metaR S6T13g
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaM arachcoa m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB04258
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
type: Species
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b2efcd69_6098_4a21_a1aa_18163bfeb661
boundary condition: true
is encoded by: hsa:51251
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: NT5C3
is: Q9H0P0

metaM c6dc c
boundary condition: false
name: adipoyl carnitine
is: HMDB00705
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaM ser L m
name: L-serine
is: CHEBI:17115
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00187
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_6658d030_d7f5_41fe_9e34_31a72cb4e68f
is: Q9UI40
boundary condition: true
constant: false
type: Species
is encoded by: hsa:25769
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC24A2

http://identifiers.org/biomodels.db/MODEL1310110038#_929554bd_b0f3_402a_8bd1_c2e14858811c
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ADCY7
is: P51828
initial concentration: NaN
is encoded by: hsa:113
has only substance units: false

metaM ptrc c
is: C00134
name: Putrescine
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01414
is: CHEBI:326268
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1b40d8df_5cf1_49f5_93f7_a1c2e96422cf
type: Species
is: Q308M7
has only substance units: false
is encoded by: hsa:5169
constant: false
name: ENPP3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM taur e
is: HMDB00251
initial concentration: 1.0
is: C00245
has only substance units: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:3544
type: Species
name: Taurine

metaR OBDHc
reactant: MODEL1310110038#
is: SBO:0000176
name: 2-Oxobutanoate dehydrogenase, cytosolic
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
type: Reaction
fast: false

metaR PUNP3
product: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Guanosine)
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: true
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

metaR DESAT18 4
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

metaM fald c
has only substance units: false
name: formaldehyde
is: SBO:0000247
initial amount: NaN
is: HMDB01426
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
constant: false
type: Species
is: CHEBI:16842

metaM leuleu e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Leucylleucine
type: Species
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
notes: FORMULA: C12H24N2O3 CHARGE: 0
boundary condition: false
constant: false

metaR r1380
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
fast: false
product: MODEL1310110038#
is: SBO:0000176
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72

metaR FACOAL180i
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110038#
name: C180 fatty acid activation
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_811061e1_264e_43e0_a8a6_75194322c20a
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: ACADVL
initial amount: NaN
initial concentration: NaN
is: P49748
is encoded by: hsa:37
has only substance units: false

metaM acetone e
is: CHEBI:15347
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01659
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone

metaM xolest2 hs e
boundary condition: false
type: Species
is: SBO:0000247
name: cholesterol ester
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:17002
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
constant: false

metaM 5oxpro c
name: 5-oxoprolinate
is: CHEBI:57606
is: HMDB00267
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
has only substance units: false
boundary condition: false

metaM ksi pre14 g
is: CHEBI:28067
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: keratan sulfate I biosynthesis, precursor 14
type: Species
is: SBO:0000247
initial amount: NaN

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM gt3 hs g
has only substance units: false
name: GT3
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28424
initial concentration: 1.0
type: Species
boundary condition: false

metaR DECCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM cysam c
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: cysteaminium
boundary condition: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029
is: SBO:0000247
initial concentration: 1.0
is: HMDB02991

metaR r0560
type: Reaction
reactant: MODEL1310110038#
reversible: false
fast: false
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_f0784232_9746_4973_bc0a_020f7d6ede45
is encoded by: hsa:5142
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: PDE4B
initial amount: NaN
is: Q5TEK5

http://identifiers.org/biomodels.db/MODEL1310110038#_9fa19279_453e_4270_9940_40504054858a
is: C9JC79
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6342
initial amount: NaN
constant: false
name: SCP2

metaR HSD17B42x
name: hydroxysteroid (17-beta) dehydrogenase 4
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use

metaR GLCt1r
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: glucose transport (uniport)
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaR H3MTer U
reversible: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
name: H3 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
fast: false

metaR ACHEe
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.7
name: Acetylcholinesterase
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_40c6def9_e39a_4876_999f_db9640d64639
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:NM 013421
has only substance units: false
name: _NM_013421_1_e

http://identifiers.org/biomodels.db/MODEL1310110038#_2c0da8ea_da4c_4c2d_adf2_125f7b57264e
is encoded by: hsa:122622
is: B3KTV4
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: ADSSL1
boundary condition: true
is: SBO:0000252

metaR ME2m
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.38
name: malic enzyme (NADP), mitochondrial
fast: false
reversible: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.40
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_b2a1d0d8_1bbd_43be_80f4_2f6596279ac8
boundary condition: true
is: P21912
name: SDHB
has only substance units: false
is encoded by: hsa:6390
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_22f701ba_171c_4c43_98ed_24a0c36f5ecb
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AI656480_1_m
initial amount: NaN
is encoded by: hsa:AI656480
has only substance units: false
constant: false
boundary condition: true

metaM ptdcacrn c
name: pendtadenoyl carnitine
is: CHEBI:18303
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaM HC02180 e
type: Species
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial concentration: 1.0
is: CHEBI:28728
name: thromboxane-b2
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_5a82dad6_b4a6_40aa_ac69_ae3798f13d95
is: O43181
constant: false
type: Species
is encoded by: hsa:4724
initial concentration: NaN
boundary condition: true
has only substance units: false
name: NDUFS4
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_6793087b_f9fe_45a3_878b_e6b65a98e4a9
is encoded by: hsa:221
type: Species
is: SBO:0000252
name: ALDH3B1
has only substance units: false
initial amount: NaN
is: P43353
constant: false
initial concentration: NaN
boundary condition: true

metaR r0812
fast: false
modifier: MODEL1310110038#
product: MODEL1310110038#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_487c402e_aacc_48f3_a03b_5098020fd87e
is: SBO:0000252
type: Species
name: VNN3
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:55350
boundary condition: true
initial concentration: NaN

metaR MM7Cbg
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110038#
type: Reaction
fast: false
product: MODEL1310110038#
is described by: ECO:0000000

metaR NADH2 u10m
is described by: ECO:0000134
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.6.99.3
is: SBO:0000185
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
type: Reaction
reversible: false
product: MODEL1310110038#
name: NADH dehydrogenase, mitochondrial
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/1.6.5.3

metaM 5oxpro e
is: HMDB00267
has only substance units: false
constant: false
name: 5-oxoprolinate
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial amount: NaN
boundary condition: false
is: CHEBI:57606

http://identifiers.org/biomodels.db/MODEL1310110038#_c7a6036c_c013_4ce8_b863_aa9ec2fac160
has only substance units: false
is: Q9Y2P5
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:10998
initial amount: NaN
constant: false
boundary condition: true
name: SLC27A5

metaR FATP6t
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110038#
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
fast: false
reactant: MODEL1310110038#
type: Reaction
name: fatty acid electroneutral transport
kinetic law: MODEL1310110038#

metaM eicostetcrn m
has only substance units: false
name: Eicosatetranoyl carnitine
is: HMDB01356
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
type: Species
boundary condition: false
is: CHEBI:57312

metaR PUNP6
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyinosine)
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110038#

metaR RE2799C
name: RE2799
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110038#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110038#

metaR r0456
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
fast: false
reactant: MODEL1310110038#
reversible: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_2c4ed55c_239f_4247_884b_75fa4d4ece65
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _AI694761_1_c
has only substance units: false
is encoded by: hsa:AI694761
constant: false
type: Species
is: SBO:0000252

metaR DAG HSter
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: diacylglycerol ER export
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000000

MODEL1310110038
reaction: metaR AG13T9g
species: metaM akg m
reaction: metaR OCTDECCACT
species: metaM cortsn r
species: metaM ala L m
reaction: metaR RE2999M
species: metaM lthstrl r
reaction: metaR SPC HSt
reaction: metaR r0994
reaction: metaR DECCRNe
reaction: metaR GLYCTDle
reaction: metaR SUCOAS1m
species: metaM gullac c
species: metaM cspg b l
reaction: metaR r0027
reaction: metaR r2080
species: metaM urate x
reaction: metaR r2095
species: metaM 5adtststerones e
reaction: metaR P4508B13r
species: metaM apoC c
reaction: metaR FAOXC225m
reaction: metaR FAOXC2051843m
reaction: metaR DMHPTCRNCPT2
species: metaM urea e
reaction: metaR r2017
reaction: metaR DMNONCRNCPT2
species: metaM man l
reaction: metaR EX imp LPAREN e RPAREN
reaction: metaR GLACter
reaction: metaR PHACCOAGLNAC
reaction: metaR GLNASNNaEx
reaction: metaR FAOXC18280m
reaction: metaR OLEICFATPtc
species: metaM tmndnccrn m
species: metaM 4fumacac c
species: metaM octe5coa m
reaction: metaR r0249
reaction: metaR FAOXC204C205x
species: metaM ksi deg11 l
reaction: metaR G14Tg
reaction: metaR G14T20g
reaction: metaR RETI1
species: metaM triodthy c
species: metaM ethamp r
reaction: metaR DURIPP
reaction: metaR T4HCINNMFM
reaction: metaR ADRNCPT2
species: metaM 3oddcoa x
reaction: metaR TMDK1
reaction: metaR DMATTx
species: metaM met L e
reaction: metaR PPA
reaction: metaR KHte
reaction: metaR r1640
reaction: metaR SERALANaEx
species: metaM lanost r
reaction: metaR ACGAMtly
reaction: metaR EX sph1p LPAREN e RPAREN
species: metaM ura e
reaction: metaR 2HBO
species: metaM bilglcur r
species: metaM his L e
reaction: metaR r1593
species: metaM thym c
species: metaM l2n2m2mn l
species: metaM etfrd m
reaction: metaR RE0926E
reaction: metaR 34HPPte
reaction: metaR SFGTH
reaction: metaR r2356
reaction: metaR AHEXASE2ly
species: metaM q10 m
reaction: metaR FAOXC11
reaction: metaR NACHEXA13ly
reaction: metaR ARGtm
species: metaM malt e
species: metaM fuc L c
species: metaM ksii core2 deg3 l
reaction: metaR PI4PLCn

metaM hdd2crn m
is: HMDB06317
initial amount: NaN
name: trans-Hexadec-2-enoyl carnitine
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR ETOHt
reactant: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
name: ethanol reversible transport
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000185

metaM ksii core2 pre6 g
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C61H98N5O46SX CHARGE: -2
name: keratan sulfate II biosynthesis, precursor 6
has only substance units: false

metaM HC02180 c
initial concentration: 1.0
name: thromboxane-b2
type: Species
is: CHEBI:28728
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b95de3a1_aa81_4316_9871_02951d8012dc
constant: false
is: B4DG68
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4842
initial amount: NaN
initial concentration: NaN
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110038#_822ad36f_0d51_4e77_8e72_c8db6d90b752
initial concentration: NaN
type: Species
name: PNPO
is: Q9NVS9
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:55163

metaR PUNP7
fast: false
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
name: purine-nucleoside phosphorylase (Xanthosine)
is described by: ECO:0000269
product: MODEL1310110038#
reactant: MODEL1310110038#

metaM Tn antigen g
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
is: C04383
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
name: Tn antigen
has only substance units: false

metaR MI14PP
kinetic law: MODEL1310110038#
name: inositol-1,4-bisphosphate 1-phosphatase
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.3.57
modifier: MODEL1310110038#
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_8dc14be5_4dc2_47de_adc3_2db9a64f692b
has only substance units: false
is encoded by: hsa:AL050025
name: _AL050025_1_c
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaM tridcoa m
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB13109
name: tridecanoylcoa
type: Species
initial amount: NaN
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false

metaR F1PGT
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
name: fucose-1-phosphate guanylyltransferase
is: SBO:0000176
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.7.30
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_6b36f374_9f37_4de8_8c6d_ae40cd3e91b2
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7498
boundary condition: true
type: Species
initial amount: NaN
name: XDH
has only substance units: false
is: P47989

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110038#
name: intracellular transport
product: MODEL1310110038#
reversible: true
type: Reaction

metaR r2325
kinetic law: MODEL1310110038#
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0129
reversible: true
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_2578f470_57cf_463f_a6e3_9e5520df6b4d
name: FUT8
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: B4DFS7
is encoded by: hsa:2530

metaR ARGtm
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110038#
name: arginine mitochondrial transport via ornithine carrier
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110038#

metaM andrstandn r
initial concentration: 1.0
name: 5alpha-androstane-3,17-dione
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: SBO:0000247
is: HMDB00899
type: Species
constant: false
is: CHEBI:15994
initial amount: NaN
has only substance units: false

metaR PEROXx
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
name: peroxisomal lumped long chain fatty acid oxidation
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_1c2f5323_77cf_410c_a047_c211764d8083
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:2686
has only substance units: false
is: A0PJJ9
name: GGT7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_7262680e_5ff1_4f50_8251_c89d372df1c5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P24310
type: Species
constant: false
name: COX7A1
is encoded by: hsa:1346
boundary condition: true

metaM 44mctr r
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: HMDB01023
initial concentration: 1.0
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: CHEBI:17813
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_fa4eb7ce_75c4_41ad_abdb_53bbbcfe9aac
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFA12
is: F8VQS7
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:55967
boundary condition: true

metaR NACDe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM 2hexdtricoa x
is: SBO:0000247
initial amount: NaN
type: Species
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
is: HMDB02288
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0a105ba4_1d28_48bb_8193_ddad56807ba9
is: Q3KT79
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: AMACR
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:23600

metaR NAGA2ly
name: N-acetylgalactosaminidase, alpha-
reversible: false
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
is: SBO:0000176
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.49
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_8b6348b9_919e_4aba_bb00_f6969b041d57
boundary condition: true
is encoded by: hsa:4707
initial concentration: NaN
is: O75438
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: NDUFB1

metaR r2326
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true

metaM HC00342 c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
is: CHEBI:16383
is: SBO:0000247
initial amount: NaN
name: cis-aconitate(3-)
type: Species

metaR PTDCACRNt
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
reversible: false
name: pentadecanoate transport into the mitochondria

metaM q10h2 m
type: Species
name: Ubiquinol-10
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB13111
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM tag hs e
is: CHEBI:17855
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
constant: false
name: triglyceride
type: Species
initial amount: NaN
has only substance units: false

metaM didp n
constant: false
boundary condition: false
is: CHEBI:28823
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
name: dIDP
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaM leu L m
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
name: L-leucine
is: CHEBI:15603
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaM HC02213 c
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:28031
name: prostaglandin-e3
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cac6e46a_7a60_4bc0_a82e_1ee1f44dd354
initial amount: NaN
is: P43251
has only substance units: false
type: Species
is encoded by: hsa:686
constant: false
initial concentration: NaN
boundary condition: true
name: BTD
is: SBO:0000252

metaR r2327
fast: false
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_2d63ae02_7d26_4ba5_8926_7177a58dfb7b
is encoded by: hsa:3295
type: Species
boundary condition: true
has part: E9PB82
is: SBO:0000297
constant: false
initial amount: NaN
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
has only substance units: false

metaR OCDCAtr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: fatty acid transport via diffusion

metaR RE0453C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110038#
name: RE0453
is: SBO:0000176
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_0541f22d_8932_4128_9011_789e291d411f
is: SBO:0000252
name: SGPP2
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q8IWX5
has only substance units: false
is encoded by: hsa:130367

http://identifiers.org/biomodels.db/MODEL1310110038#_70807ddd_596a_4e19_9882_38f1d76e6d13
initial concentration: NaN
constant: false
type: Species
has only substance units: false
has part: P50993
name: ATP1B4:ATP1A2
has part: Q9UN42
is encoded by: hsa:23439
initial amount: NaN
is encoded by: hsa:477
boundary condition: true
is: SBO:0000297

metaR MMSAD3m
fast: false
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.27
is described by: ECO:0000269
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a779834d_2fb0_4582_8f97_b647214f423c
is encoded by: hsa:8776
has only substance units: false
boundary condition: true
type: Species
name: MTMR1
constant: false
initial amount: NaN
initial concentration: NaN
is: Q13613
is: SBO:0000252

metaR GSNt
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
name: guanosine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
reversible: true

metaM octd11ecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
is: HMDB06294
initial amount: NaN
name: 11-octadecenoylcoa
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_168a3b82_6bf0_448a_b735_f01be4b533b4
is encoded by: hsa:4538
is: SBO:0000252
boundary condition: true
is: P03905
initial concentration: NaN
has only substance units: false
name: ND4
initial amount: NaN
constant: false
type: Species

metaR GLYPHEHYc
kinetic law: MODEL1310110038#
is: SBO:0000176
name: hydrolysis of glycylphenylalanine
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000134
fast: false
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.

http://identifiers.org/biomodels.db/MODEL1310110038#_2d48649e_7fb3_4653_a382_f44f1a8e1529
name: MPST
initial concentration: NaN
is encoded by: hsa:4357
is: P25325
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_d7c1ba17_3d12_416e_9e8b_ad545f0bd434
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: PIGX
is: Q8TBF5
is encoded by: hsa:54965
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_6be073c3_b78e_4aa9_8a8c_bbcbf4f4849a
constant: false
initial concentration: NaN
boundary condition: true
name: ND3
is: P03897
type: Species
has only substance units: false
is encoded by: hsa:4537
initial amount: NaN
is: SBO:0000252

metaR SUCCtp
fast: false
name: succinate transporter, peroxisome
type: Reaction
is: SBO:0000185
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110038#

metaR PGI
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110038#
is: SBO:0000176
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
name: glucose-6-phosphate isomerase
reversible: true
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM cs a deg3 l
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
constant: false
initial concentration: 1.0
is: CHEBI:15748
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB00127
type: Species

metaM so3 c
type: Species
has only substance units: false
boundary condition: false
is: HMDB00240
is: CHEBI:17137
constant: false
name: Sulfite
initial concentration: 1.0
initial amount: NaN
is: C00094
is: SBO:0000247
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

metaR r2328
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110038#

metaR KHte
reversible: true
fast: false
type: Reaction
is described by: ECO:0000134
name: KHte
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_7cc98848_f9eb_4f2b_9d96_01cc690df0b7
is encoded by: hsa:123041
initial amount: NaN
initial concentration: NaN
is: Q8NFF2
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC24A4

http://identifiers.org/biomodels.db/MODEL1310110038#_89a2fbc0_20c4_4528_9308_f038ed2c6f2c
constant: false
is: SBO:0000297
initial amount: NaN
name: SLC7A11:SLC3A2
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
has part: Q9UPY5
is encoded by: hsa:23657

metaR DPMVDx
modifier: MODEL1310110038#
fast: false
name: diphosphomevalonate decarboxylase
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000134
reversible: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.1.1.33
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_ad1cbaa1_32bc_46af_a41c_a1d6eed6f3d5
is: Q9UPY5
is encoded by: hsa:23657
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC7A11
constant: false
initial amount: NaN
type: Species

metaR MAL Ltx
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
fast: false
name: Transport reaction for malate
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reversible: true
product: MODEL1310110038#

metaR NDPK3m
modifier: MODEL1310110038#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110038#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110038#

metaM arachcoa c
constant: false
is: SBO:0000247
is: HMDB04258
type: Species
initial concentration: 1.0
name: arachidyl coenzyme A
boundary condition: false
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
has only substance units: false

metaM ppi x
is: SBO:0000247
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: C00013
has only substance units: false
boundary condition: false
is: HMDB00250
initial concentration: 1.0
type: Species
is: CHEBI:33019
constant: false

metaM cs b deg1 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
has only substance units: false
type: Species
is: HMDB00812
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
constant: false
is: CHEBI:16953

metaM mgacpail hs r
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: HMDB00220
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:7896
is: SBO:0000247
is: C00249
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_8afcb39b_54ea_4e53_90af_41e522ddae7e
is encoded by: hsa:517
name: ATP5G2
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_dfbed48c_e220_4917_827f_fad66f5ca3b3
type: Species
is: Q9NNW7
is encoded by: hsa:10587
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: TXNRD2
has only substance units: false

metaR NACHEX2ly
reactant: MODEL1310110038#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110038#
type: Reaction
fast: false
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_afd05c5b_cc40_42ad_a280_8e38993753d6
is encoded by: hsa:10768
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: O43865
initial concentration: NaN
initial amount: NaN
name: AHCYL1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_13396b46_985c_4cca_8456_bad8ffbef03d
is: Q9UHK6
is: SBO:0000252
name: AMACR
is encoded by: hsa:23600
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaR NDPK3n
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is: SBO:0000176
reversible: true

metaR HSD11B2r
name: 11-beta-hydroxysteroid dehydrogenase type 2
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.146
modifier: MODEL1310110038#
reversible: true

metaM 3octdectecoa m
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
is: SBO:0000247
name: 3,6,9,12-octadecatetraenoylcoa
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR r2321
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR HBZOPT10m
kinetic law: MODEL1310110038#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
product: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
is: SBO:0000176
name: Hydroxybenzoate Decaprenyltransferase
is version of: http://identifiers.org/ec-code/2.5.1.39
modifier: MODEL1310110038#

metaR IMPC
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110038#
is described by: ECO:0000269
fast: false
name: IMP cyclohydrolase
kinetic law: MODEL1310110038#

metaM mma c
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C1H6N CHARGE: 1 INCHI: InChI=1S/CH5N/c1-2/h2H2,1H3/p+1 EHMN_ABBREVIATION: C00218
is: SBO:0000247
has only substance units: false
is: HMDB00164
is: CHEBI:59338
initial amount: NaN
name: methylammonium

metaR 4MOPt2im
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110038#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaR OAGT3te
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
fast: false
is described by: ECO:0000000
name: oagt3 hs transport

http://identifiers.org/biomodels.db/MODEL1310110038#_c9446323_0e6a_4d7d_9682_bfefe7a8118d
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:509
name: ATP5C1
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
is: P36542

metaR DM dsT antigen g
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c107005f_05a8_4a5e_97e3_c2a1246150ea
is: Q13825
initial concentration: NaN
type: Species
name: AUH
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:549

http://identifiers.org/biomodels.db/MODEL1310110038#_95d7b55e_620d_4fc4_9cb6_0ab87402cf4c
constant: false
is: SBO:0000252
name: SLC27A2
initial concentration: NaN
is: O14975
boundary condition: true
is encoded by: hsa:11001
has only substance units: false
type: Species
initial amount: NaN

metaR r2322
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d0602f37_addb_477a_a45e_da395710af0f
initial concentration: NaN
type: Species
is: SBO:0000252
is: P46721
name: SLCO1A2
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:6579

metaM c4dc x
is: HMDB02013
boundary condition: false
is: C02862
constant: false
notes: FORMULA: C11H18NO6 CHARGE: -1
name: succinyl carnitine
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
type: Species
initial amount: NaN

metaM ksii core2 deg2 l
type: Species
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 2
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: CHEBI:12936
is: HMDB00143
has only substance units: false
initial amount: NaN

metaR F6Tg
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.68
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
name: glycoprotein 6-alpha-L-fucosyltransferase
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD

metaR TSULt4 3
type: Reaction
modifier: MODEL1310110038#
reversible: true
fast: false
name: thiosulfate transport via sodium symport
is described by: ECO:0000269
reactant: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_3176902b_415d_46fb_a492_54bd4f142031
is encoded by: hsa:8875
initial concentration: NaN
name: VNN2
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: O95498
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_78fdd049_7ae0_44cd_9eae_a26831a4d77f
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7359
name: _7359_1_c
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR r2323
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110038#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaM 4mop m
name: 4-methyl-2-oxopentanoate
has only substance units: false
is: CHEBI:17865
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

metaM ptrc e
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
type: Species
has only substance units: false
is: C00134
initial amount: NaN
initial concentration: 1.0
is: CHEBI:326268
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01414

metaR HEXCOAACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d5288163_091f_49b1_9460_d0459ce467c5
boundary condition: true
constant: false
initial concentration: NaN
is: P11182
has only substance units: false
name: DBT
is encoded by: hsa:1629
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_71ec9b70_0cde_4852_a389_104dfc12726b
is: SBO:0000252
name: SLC38A4
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q969I6
boundary condition: true
constant: false
is encoded by: hsa:55089
type: Species

metaR OAGT3tg
product: MODEL1310110038#
reversible: true
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: oagt3 hs intracellular transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#

metaR SERDGLYexR
is described by: ECO:0000304
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185
fast: false
name: D-Serine/Glycine reversible exchange
reversible: true
kinetic law: MODEL1310110038#

metaR PI345P5P
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_342c7163_28e3_466a_8692_29e3caab4779
constant: false
is: SBO:0000252
is encoded by: hsa:5167
is: P22413
boundary condition: true
has only substance units: false
initial amount: NaN
name: ENPP1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_70b045ed_e3a1_4602_9e7a_52d40c82a104
is encoded by: hsa:28976
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: Q9H845
name: ACAD9
boundary condition: true

metaR r2324
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction

metaR S6TASE8ly
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_b13261f8_d331_481c_a30b_db8b663070f4
constant: false
is encoded by: hsa:54344
has only substance units: false
is encoded by: hsa:8813
is encoded by: hsa:8818
has part: Q86TM7
initial concentration: NaN
has part: O94777
type: Species
is: SBO:0000297
has part: O60762
boundary condition: true
initial amount: NaN
name: DPM3:DPM1:DPM2

http://identifiers.org/biomodels.db/MODEL1310110038#_3260106d_c136_42d2_8d35_a2a6bc0f6dd9
boundary condition: true
is encoded by: hsa:285973
constant: false
is: Q674R7
has only substance units: false
type: Species
name: ATG9B
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_79293f47_0507_495c_a55f_989c41643322
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:954
type: Species
name: ENTPD2
constant: false
is: Q5SPY7

metaM duri n
name: 2'-deoxyuridine
is: HMDB00012
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
type: Species
constant: false
is: CHEBI:16450
boundary condition: false

metaM ksii core4 pre5 g
type: Species
is: CHEBI:58053
is: C00130
notes: FORMULA: C69H112N6O48X CHARGE: -1
is: HMDB00175
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 5
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_d2c5b9f1_3997_433c_b385_bcebea7e44b5
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: A0PJM6
is encoded by: hsa:1120
has only substance units: false
name: CHKB
boundary condition: true

metaR LCADi D
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: lactaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
reversible: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.36

metaM dump n
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
name: dUMP(2-)
constant: false
is: HMDB01409
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:246422

metaM oh1 e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: HO CHARGE: -1
is: HMDB01039
is: C01328
name: hydroxide ion
type: Species
has only substance units: false
is: SBO:0000247

metaM tettet6 e
is: SBO:0000247
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: HMDB06246
name: tetracosatetraenoic acid n-6
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_c778444b_9395_407a_9ea8_fc0e4a7d162c
name: PLCB4
is: E2QRH8
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:5332
is: SBO:0000252

metaR NH4t3r
kinetic law: MODEL1310110038#
is described by: ECO:0000269
name: ammonia transport via proton antiport
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_1ea97583_13eb_40e6_b755_c4ccd4d1d783
initial amount: NaN
name: SLC5A7
initial concentration: NaN
is: Q9GZV3
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:60482
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM e4hglu m
boundary condition: false
constant: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
name: erythro-4-hydroxy-L-glutamate(1-)
is: CHEBI:6331
is: HMDB02273
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_02df4e64_d7d4_4fc6_b339_3961ab710e44
is encoded by: hsa:1595
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CYP51A1
constant: false
is: Q16850
type: Species
initial concentration: NaN

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.99.3
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is described by: ECO:0000000
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.6.5.3
is: SBO:0000176
fast: false

metaM leu L c
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-leucine
boundary condition: false
is: CHEBI:15603
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
is: HMDB00687
is: SBO:0000247

metaR TMNDNCCRNt
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_c2851501_78f2_4fc7_b465_a783ed2b0491
initial concentration: NaN
boundary condition: true
is encoded by: hsa:220
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: ALDH1A3
is: P47895

metaM prostgi2 c
initial amount: NaN
is: SBO:0000247
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
boundary condition: false
is: HMDB01335
initial concentration: 1.0
is: CHEBI:57403
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e3309e9d_b7b1_4f2c_b00a_2daf12788a8a
is: Q9BTU6
boundary condition: true
constant: false
name: PI4K2A
type: Species
is encoded by: hsa:55361
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM ppi n
is: SBO:0000247
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
name: diphosphate(3-)
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00250
has only substance units: false
initial concentration: 1.0

metaR AHC
fast: false
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.3.1.1
reactant: MODEL1310110038#
is described by: ECO:0000269
reversible: true
product: MODEL1310110038#
name: adenosylhomocysteinase
kinetic law: MODEL1310110038#

metaM leu L e
initial amount: NaN
is: HMDB00687
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
has only substance units: false
is: CHEBI:15603
is: SBO:0000247
constant: false
name: L-leucine
initial concentration: 1.0

metaR FAOXC12DCTc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

metaR FAOXC183C163Gm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM 4mlacac c
is: CHEBI:17105
type: Species
name: 4-maleylacetoacetate
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB02052
boundary condition: false
initial concentration: 1.0

metaR DCK1n
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Deoxycytidine kinase, nuclear (ATP)
reactant: MODEL1310110038#
modifier: MODEL1310110038#
reversible: true
is: SBO:0000176

metaR OCTDECCPT2
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_ad252979_649b_4afd_b0c1_b3e54677a678
has only substance units: false
boundary condition: true
name: GPX1
is encoded by: hsa:2876
is: SBO:0000252
is: P07203
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR CH25H
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.99.38
reversible: false
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: cholesterol 25-hydroxylase
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
is described by: ECO:0000269

metaM gcald c
is: HMDB03344
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
name: glycolaldehyde
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: CHEBI:17071
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e7f841ec_c625_4196_b968_7eec9053698c
constant: false
initial amount: NaN
is: SBO:0000252
is: Q6IBA0
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
name: NDUFS5
is encoded by: hsa:4725

metaM maltpt e
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
boundary condition: false
is: http://identifiers.org/pubchem.compound/5141
is: C02052
initial concentration: 1.0
name: maltopentaose
has only substance units: false
is: HMDB01296

metaM CE5120 m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: CHEBI:57923
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR RE2954C
fast: false
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: RE2954
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_02a9f8e4_4d3d_4548_a82e_bd59134a6af7
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI601100
is: SBO:0000252
name: _AI601100_1_m
constant: false
initial concentration: NaN

metaM adrncoa c
is: http://identifiers.org/pubchem.compound/47205480
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
is: C16170
type: Species
has only substance units: false
boundary condition: false
name: adrenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110038#_0e902100_2286_4ea7_9cce_334044458f4d
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q8TD20
has only substance units: false
type: Species
is encoded by: hsa:154091
name: SLC2A12

http://identifiers.org/biomodels.db/MODEL1310110038#_d57f63e2_1a9e_4f06_a513_7bc7d6dcb8bb
has only substance units: false
name: DPM1
is: O60762
constant: false
initial amount: NaN
is encoded by: hsa:8813
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_d60ba5a9_e4b4_42e9_8710_b714388a8b56
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: _W74642_1_c
is encoded by: hsa:W74642

metaM dd5ecoa m
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
is: HMDB13028
is: C01942
initial concentration: 1.0
is: SBO:0000247
name: 5-dodecenoylcoa
boundary condition: false

metaR URIt
fast: false
kinetic law: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
name: uridine facilated transport in cytosol
reactant: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
is: SBO:0000185

metaR LPS
reversible: false
kinetic law: MODEL1310110038#
name: lipase
product: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:carbonyl and extra H accounted for in R group NJ
is version of: http://identifiers.org/ec-code/3.1.1.34
is: SBO:0000176
type: Reaction

metaM m7masnC g
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:58401
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: HMDB06814
type: Species
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)

metaR LGTHL
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is version of: http://identifiers.org/ec-code/4.4.1.5
fast: false
modifier: MODEL1310110038#
name: lactoylglutathione lyase
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR ILEPHELAT2tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_24b3d332_548f_4edb_a2fb_5fed94890fa7
initial amount: NaN
is: Q59EH3
name: ACP1
initial concentration: NaN
is encoded by: hsa:52
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR CHOLK
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110038#
fast: false
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000269
reversible: false
name: Choline kinase

metaM vacccoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/9543677
type: Species
boundary condition: false
is: HMDB06521
has only substance units: false
is: SBO:0000247
name: vaccenyl coenzyme A

metaR OCTDECCPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR EX psyltchol LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-taurocholic acid complex
type: Reaction

metaR PPItm
is: SBO:0000185
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
is described by: ECO:0000134
type: Reaction

metaR ASNtm
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is described by: ECO:0000000
name: L-asparagine transport, mitochondrial
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: false
type: Reaction

metaM air c
initial amount: NaN
constant: false
type: Species
is: C03373
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: CHEBI:58592
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01235

metaM pacald c
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB06236
is: CHEBI:16424
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
name: phenylacetaldehyde
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_1590c1f3_b9ac_422d_8b41_2d056b65d8e6
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: _100128062_1_m
is encoded by: hsa:100128062
constant: false

metaR PHEMEt
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
reactant: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
type: Reaction
name: heme transport
product: MODEL1310110038#
is described by: ECO:0000269
reversible: false
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_049d3e40_6628_47b1_a454_4455ac7bb901
is encoded by: hsa:54995
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9NWU1
is: SBO:0000252
has only substance units: false
type: Species
name: OXSM

metaM 3octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
initial amount: NaN
name: 3,6,9,12-octadecatetraenoylcoa
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR PDE1
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction
modifier: MODEL1310110038#
fast: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
reactant: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD

metaR RE1845C
is: SBO:0000176
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: RE1845
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
fast: false
is described by: ECO:0000000

metaR PTCRTD
type: Reaction
kinetic law: MODEL1310110038#
name: diffusion of putriscine into the endothelial cells
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reversible: true
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_ecaaf597_cff8_4084_92f3_7172ab87d474
initial concentration: NaN
is encoded by: hsa:AI935189
name: _AI935189_1_m
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR ACOAD10m
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
modifier: MODEL1310110038#
type: Reaction
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
reversible: false
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_5dc56f10_1b48_417b_adf6_8026ab6ba58e
initial amount: NaN
type: Species
is: Q53H96
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:65263
boundary condition: true
name: PYCRL

metaR FAOXC16DCr
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR 3MOPt2im
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cdc3376e_e438_48d6_a703_f2c628c7b7b2
constant: false
is: Q9H999
boundary condition: true
is: SBO:0000252
name: PANK3
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:79646

metaM 3ddecdicoa m
is: C05280
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
is: HMDB03952
initial concentration: 1.0
constant: false
name: 3,6-dodecadienoylcoa
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM dolmanp U r
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
initial amount: NaN
is: CHEBI:15809
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog

http://identifiers.org/biomodels.db/MODEL1310110038#_9f77be13_220e_421e_a5a1_28e09178cecf
name: _AA021081_1_r
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AA021081
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r2329
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110038#

metaR PGK
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.2.3
fast: false
name: phosphoglycerate kinase
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000134
reversible: true

metaM 4mop c
initial concentration: 1.0
is: CHEBI:17865
is: HMDB00695
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: SBO:0000247

metaR LPS3e
reversible: false
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
modifier: MODEL1310110038#
name: lipase, extracellular
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#

metaR C121CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaM tdcoa c
is: CHEBI:57385
is: C02593
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species
is: HMDB01521
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_2e63d84f_5c3c_4c21_b50c_f5d4fd25c3b4
initial amount: NaN
is: SBO:0000252
name: NDUFA6
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4700
is: P56556
initial concentration: NaN
boundary condition: true

metaR C51CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaM C02528 r
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:36234
name: chenodeoxycholate
type: Species
constant: false
is: HMDB00518

metaR RE0453M
reversible: true
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: RE0453
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_a5e364c4_2454_43f0_81f7_d7ac11b84f6b
is: Q9Y2Q0
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:10396
name: ATP8A1
initial amount: NaN

metaM 2obut c
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
is: C00109
is: HMDB00005
is: CHEBI:16763
name: 2-Oxobutanoate

metaM ppi r
name: Diphosphate
is: C00013
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
boundary condition: false
constant: false
is: CHEBI:33019
has only substance units: false
is: HMDB00250

metaM ksi deg14 l
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
type: Species
constant: false
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 14
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_04040bf1_de84_49c9_b3da_badacd641e90
name: SLC12A7
is: SBO:0000252
constant: false
is encoded by: hsa:10723
type: Species
initial amount: NaN
boundary condition: true
is: Q9Y666
has only substance units: false
initial concentration: NaN

metaR AG13T18g
fast: false
reversible: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d2321234_0c9d_458b_86fa_f3ef99c7d425
has only substance units: false
name: CMA1
is encoded by: hsa:1215
constant: false
boundary condition: true
initial amount: NaN
is: Q4FEB3
type: Species
is: SBO:0000252
initial concentration: NaN

metaM oh1 c
type: Species
notes: FORMULA: HO CHARGE: -1
initial amount: NaN
constant: false
name: hydroxide ion
has only substance units: false
is: HMDB01039
boundary condition: false
is: SBO:0000247
is: C01328
initial concentration: 1.0

metaM 4mop e
is: SBO:0000247
is: HMDB00695
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
type: Species
constant: false
name: 4-methyl-2-oxopentanoate

metaR PMTCOAFABP1tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of palmitoyl coA into the enterocytes
type: Reaction

metaR RE3003M
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3003
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110038#
modifier: MODEL1310110038#

metaR r1378
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#

metaR VACCCRNt
name: transport into the mitochondria (carnitine)
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
reversible: false
is: SBO:0000185

metaR RE2999M
reversible: true
modifier: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110038#
name: RE2999

http://identifiers.org/biomodels.db/MODEL1310110038#_4b75a73d_b34c_43d1_8274_c01c3d68f532
is: SBO:0000252
constant: false
is: F8VQS7
initial concentration: NaN
name: NDUFA12
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:55967
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c7a06882_15e4_4301_9669_1af956b61d1a
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:39
is: Q9BWD1
has only substance units: false
name: ACAT2

metaM ptrc m
type: Species
has only substance units: false
name: 1,4-butanediammonium
constant: false
is: CHEBI:326268
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 INCHI: InChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2/p+2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial concentration: 1.0
is: HMDB01414
boundary condition: false
is: SBO:0000247

metaM HC02213 e
constant: false
name: prostaglandin-e3
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:28031
has only substance units: false

metaR EX CE1935 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine monoaldehyde exchange
type: Reaction

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b4e4161a_4106_47fd_be3b_a7262f97905e
name: GOT1
initial amount: NaN
type: Species
is: P17174
boundary condition: true
is encoded by: hsa:2805
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR C8DCc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaM tag hs c
constant: false
is: CHEBI:17855
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0

metaR r1377
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110038#
reversible: true
is: SBO:0000176
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000

metaM lnlccoa m
initial concentration: 1.0
is: HMDB01064
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
constant: false
initial amount: NaN
name: linoleic coenzyme A
boundary condition: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_2e8dd716_5e29_47ab_90c3_986482a45506
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3157
initial amount: NaN
name: HMGCS1
is: Q01581
constant: false
type: Species

metaR PGDI
is version of: http://identifiers.org/ec-code/5.3.99.2
name: Prostaglandin-H2 D-isomerase [Precursor]
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.5.1.18
modifier: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
fast: false

metaR PPItr
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true

metaR RE0577C
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
name: RE0577
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110038#
fast: false

metaR RE0453N
name: RE0453
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_5fb772a8_00fc_4c02_815b_5d3394c255ab
is: SBO:0000252
initial concentration: NaN
name: ATP5J
initial amount: NaN
constant: false
is: Q6IB54
type: Species
is encoded by: hsa:522
has only substance units: false
boundary condition: true

metaM 1pipdn2c x
type: Species
boundary condition: false
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
has only substance units: false
is: HMDB01084
name: 1-piperideine-2-carboxylate
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_e9c23907_c4bf_45b9_9bcc_b21f1f7d244d
type: Species
is: SBO:0000252
name: _AA177072_1_x
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA177072

http://identifiers.org/biomodels.db/MODEL1310110038#_b55af2bc_aa5f_4024_8ca6_93e575a03363
has only substance units: false
is encoded by: hsa:80025
constant: false
is: Q6P1K9
is: SBO:0000252
name: PANK2
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaR CYTK11
reactant: MODEL1310110038#
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dGTP)

metaM pail4p hs n
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
is: CHEBI:58178
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaR r0714
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaR 34DHOXPEGt
reversible: true
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000185
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#

metaR LCADi
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
reversible: false
name: lactaldehyde dehydrogenase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110038#

metaM idour l
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
boundary condition: false
has only substance units: false
name: L-iduronate
is: CHEBI:21338
is: SBO:0000247

metaR r0441
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#

metaM noncoa m
type: Species
boundary condition: false
is: C01942
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB13028
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
name: nonanoylcoa

metaM 4hpro LT c
boundary condition: false
type: Species
constant: false
has only substance units: false
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: HMDB00725
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18095

metaR SRTNtu
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
name: Serotonin uniport
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_9271a0e4_f771_4f16_a7ca_d86ceb7dfb18
initial concentration: NaN
is encoded by: hsa:2538
name: G6PC
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: P35575

http://identifiers.org/biomodels.db/MODEL1310110038#_212099ea_e309_4c87_83bb_e9ef5c4039fd
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: SLC28A3
initial amount: NaN
has only substance units: false
is: Q9HAS3
is encoded by: hsa:64078

http://identifiers.org/biomodels.db/MODEL1310110038#_2a9634bd_0531_470f_9dce_342b5a8604fe
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NDUFA4
is encoded by: hsa:4697
type: Species
is: O00483

metaM adrncoa m
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
name: adrenyl coenzyme A
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
type: Species

metaR RE1520M
is described by: ECO:0000000
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110038#
name: RE1520
reversible: true
type: Reaction
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR CYTK10
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dGTP)
kinetic law: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d1452b3d_bb20_4529_8e16_e29e81b226d3
name: COX1
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4512
is: Q7GXY8

metaR r0553
fast: false
reversible: true
kinetic law: MODEL1310110038#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000176

metaR C9BRxtc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_5487b590_6356_4358_92e1_134ac807f4af
type: Species
constant: false
is: P28330
name: ACADL
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:33
has only substance units: false
boundary condition: true

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM c6dc x
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB04047
is: C14143
name: adipoyl carnitine
initial concentration: 1.0
notes: FORMULA: C13H22NO6 CHARGE: -1
type: Species
has only substance units: false

metaR O2ter
is: SBO:0000185
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110038#

metaR r0716
kinetic law: MODEL1310110038#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
fast: false
reversible: false

metaR RE3367E
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
name: RE3367
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_ce6ad7d0_10a9_488d_8117_6e5fda2435e9
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: O60312
name: ATP10A
constant: false
is encoded by: hsa:57194
is: SBO:0000252
initial concentration: NaN

metaR r0552
product: MODEL1310110038#
is: SBO:0000176
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_aeab2940_acee_4eae_8450_f8c867d72fa9
initial concentration: NaN
name: FDPS
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: P14324
initial amount: NaN
is encoded by: hsa:2224
type: Species

metaM cmpacna n
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812
initial amount: NaN

metaR 3HKYNAKGAT
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reversible: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaR CSNATr
type: Reaction
product: MODEL1310110038#
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
reversible: true
name: carnitine O-acetyltransferase
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
is described by: ECO:0000000

metaM crtsl r
type: Species
has only substance units: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
boundary condition: false
constant: false
is: SBO:0000247
name: cortisol
is: CHEBI:17650
is: HMDB00063
initial amount: NaN
initial concentration: 1.0

metaR PYAM5POr
is described by: ECO:0000269
product: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
fast: false
type: Reaction
name: pyridoxamine 5'-phosphate oxidase
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.5
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
reversible: true
reactant: MODEL1310110038#

metaM xoldiolone r
is: SBO:0000247
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
is: HMDB02197
has only substance units: false
constant: false
is: CHEBI:28477
boundary condition: false
type: Species
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

http://identifiers.org/biomodels.db/MODEL1310110038#_54a04b72_dd96_44bb_8b60_ca22175eced9
name: ST8SIA1
boundary condition: true
constant: false
is: Q92185
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6489
has only substance units: false

metaM damp c
has only substance units: false
type: Species
is: HMDB00905
name: dAMP(2-)
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM sgalside hs g
initial concentration: 1.0
type: Species
boundary condition: false
name: sulfatide galactocerebroside
is: HMDB00061
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:58343

metaR BILGLCURtr
is described by: ECO:0000000
type: Reaction
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR RE0383C
modifier: MODEL1310110038#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000000
fast: false
name: RE0383
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:

metaR OCCOAtx
reactant: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false

metaR r0558
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
product: MODEL1310110038#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
fast: false
is described by: ECO:0000000
modifier: MODEL1310110038#
is: SBO:0000176

metaR DMNONCOACRNCPT1
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: DMNONCOACRNCPT1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000

metaR r0718
is version of: http://identifiers.org/ec-code/1.1.1.181
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false

metaM sgalside hs l
is: CHEBI:16349
has only substance units: false
is: SBO:0000247
name: sulfatide galactocerebroside
initial amount: NaN
is: HMDB00904
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false

metaR CSEPASEly
is: SBO:0000176
reversible: false
fast: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM pail35p hs c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5

metaR GLCtg
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
reversible: true
modifier: MODEL1310110038#
name: glucose transport, Golgi apparatus
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110038#

metaR OCT11EFATP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_21baa80d_8557_4a8a_a2c9_3a2c5f798f3b
is encoded by: hsa:100287639
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: _100287639_1_c

metaR r0940
name: Free diffusion
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

metaR CSNATp
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110038#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
is: SBO:0000176
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
reactant: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
reversible: true

metaM 4mptnl c
is: HMDB01318
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: CHEBI:17998
has only substance units: false
constant: false
name: 4-methylpentanal
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_80565d4f_9b15_4e82_b2f6_e77db6d4d978
initial amount: NaN
type: Species
is encoded by: hsa:6390
constant: false
initial concentration: NaN
name: SDHB
is: SBO:0000252
is: P21912
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_36f844a9_00dc_4a27_85f3_233d0ad97eef
name: TPI1
type: Species
initial concentration: NaN
has only substance units: false
is: Q53HE2
boundary condition: true
is encoded by: hsa:7167
initial amount: NaN
is: SBO:0000252
constant: false

metaR MAOX
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:11136547,PMID:14715500,PMID:9131641 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
name: Methylamine oxidase
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176

metaM g2m8mpdol U r
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:59093
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false

metaM didp c
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
is: HMDB03536
constant: false
name: dIDP
is: CHEBI:28823

metaM uri e
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
name: Uridine
type: Species
has only substance units: false
is: CHEBI:16704
is: HMDB00296
initial amount: NaN
is: SBO:0000247
constant: false
is: C00299

metaR PPItx
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Diphosphate transporter, peroxisome
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_c96a5ade_907a_48d8_bf32_8970dccabb89
constant: false
is: Q13232
boundary condition: true
has only substance units: false
name: NME3
is encoded by: hsa:4832
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR SBTR
type: Reaction
fast: false
is described by: ECO:0000269
name: D-sorbitol reductase
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110038#_6787c931_7535_4651_a863_cba1ccadd336
is encoded by: hsa:5281
type: Species
name: PIGF:PIGO
constant: false
is: SBO:0000297
initial concentration: NaN
has part: Q6IB04
initial amount: NaN
is encoded by: hsa:84720
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_365979f7_918e_4d4a_86d8_732afc492eab
boundary condition: true
name: OGDHL
initial concentration: NaN
type: Species
has only substance units: false
is: Q9ULD0
is encoded by: hsa:55753
is: SBO:0000252
constant: false
initial amount: NaN

metaR CSNATm
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
kinetic law: MODEL1310110038#
fast: false
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
modifier: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
reversible: true

metaR ADRNCPT2
is described by: ECO:0000000
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
type: Reaction
product: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR RE2658R
name: RE2658
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000

metaR NCKt
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: Na+/Ca2+-K+ exchange
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM dump m
is: SBO:0000247
has only substance units: false
is: CHEBI:246422
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
type: Species
initial concentration: 1.0
is: HMDB01409
boundary condition: false
name: dUMP(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_af2c7f5c_a3a2_4e6a_a811_da40ac4706c9
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:2108
has only substance units: false
constant: false
has part: P13804
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2109
name: ETFA:ETFB

metaM 4hpro LT e
name: trans-4-hydroxy-L-proline
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00725
constant: false
type: Species

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00175
is: C00130
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_32e69507_35a6_4e1b_9884_e054f583976d
boundary condition: true
constant: false
type: Species
is encoded by: hsa:55577
has only substance units: false
name: NAGK
initial amount: NaN
is: Q9UJ70
is: SBO:0000252
initial concentration: NaN

metaM tdcoa m
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
boundary condition: false
is: C02593
initial concentration: 1.0
is: CHEBI:57385
initial amount: NaN
is: HMDB01521

metaR r0942
reactant: MODEL1310110038#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_0c4d6855_839a_4b7d_a6c4_a96c99d4065e
is: SBO:0000252
name: ATP5L
type: Species
initial amount: NaN
constant: false
is: O75964
initial concentration: NaN
is encoded by: hsa:10632
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_5e2f47b1_2c19_4673_8c85_5c53fa6c204b
boundary condition: true
is encoded by: hsa:2181
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: O95573
name: ACSL3

metaR r0556
reversible: true
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110038#
is described by: ECO:0000000

metaR COQ7m
kinetic law: MODEL1310110038#
name: Ubiquinone biosynthesis COQ7
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
is: SBO:0000176
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_3a783d50_032b_4282_8b2a_a74a9ac44f3a
type: Species
name: SDHC
has only substance units: false
is encoded by: hsa:6391
is: SBO:0000252
boundary condition: true
is: Q99643
initial amount: NaN
initial concentration: NaN
constant: false

metaR ADRNCPT1
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110038#
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110038#
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000

metaM tettet6 c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB06246
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
constant: false
name: tetracosatetraenoic acid n-6
has only substance units: false

metaR r1695
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
modifier: MODEL1310110038#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000

metaR O2t
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185

metaR r0941
is: SBO:0000185
reversible: true
reactant: MODEL1310110038#
fast: false
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#

metaM ppi m
is: HMDB00250
name: Diphosphate
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:33019
has only substance units: false
is: C00013

metaR ALAGLNexR
modifier: MODEL1310110038#
is described by: ECO:0000304
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
fast: false
name: L-alanine/glutamine reversible exchange
type: Reaction
reactant: MODEL1310110038#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR SUCCt4 2
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
name: succinate transport via sodium symport
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR HDECAACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

metaM HC01118 r
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
type: Species
is: CHEBI:57310
name: presqualene diphosphate(3-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR MELATNOX
product: MODEL1310110038#
name: Melatonin:NADP oxidoreductase
fast: false
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.14.1
is version of: http://identifiers.org/ec-code/1.14.13.48

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR P5CR
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: pyrroline-5-carboxylate reductase

metaM eicostet e
has only substance units: false
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB02177
initial concentration: 1.0
constant: false
type: Species
name: eicosatetranoic acid

http://identifiers.org/biomodels.db/MODEL1310110038#_baf7c4f6_3812_4726_89b3_2ae84a382083
name: UROC1
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q68CJ7
is encoded by: hsa:131669
initial amount: NaN

metaR GTHPm
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000269
name: glutathione peroxidase, mitochondria
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.11.1.12
type: Reaction
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)

metaR r0944
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110038#
name: Active transport
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_f70277ec_84d5_4ffa_b1e6_48af045fbeeb
is: Q8N695
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: SLC5A8
constant: false
initial concentration: NaN
is encoded by: hsa:160728
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_8daef154_bd15_4e2e_8925_acc9aca3039b
initial amount: NaN
is: Q9BX95
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:81537
boundary condition: true
name: SGPP1
initial concentration: NaN
constant: false

metaR 3SPYRSPm
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110038#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
reactant: MODEL1310110038#
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM

metaM glygn5 e
is: CHEBI:17754
is: C00116
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00131
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
has only substance units: false
notes: FORMULA: C12H21O11X CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false

metaM idour c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: L-iduronate
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
constant: false
initial amount: NaN
type: Species
boundary condition: false

metaR AKGtp
fast: false
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
name: AKG transporter, peroxisome
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_cb73f0a3_db2a_4b67_b9c8_6fd2d3ef3e66
initial concentration: NaN
name: HADH
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q16836
is encoded by: hsa:3033

http://identifiers.org/biomodels.db/MODEL1310110038#_1846cb31_16af_4363_9502_50849e470a45
is: Q9NUB1
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:84532
initial amount: NaN
name: ACSS1

metaR 4HOXPACDOX NADP
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_2d8b340b_8677_4fc2_bcc8_2df445cee56e
initial amount: NaN
boundary condition: true
is encoded by: hsa:26
type: Species
initial concentration: NaN
name: ABP1
has only substance units: false
constant: false
is: SBO:0000252
is: P19801

metaR FAOXC184C163m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR PRFGS
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.3
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylformylglycinamidine synthase
is: SBO:0000176
kinetic law: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_7eb0d172_5978_4cd9_9729_ecbcaac6763e
type: Species
initial amount: NaN
has only substance units: false
is: P48736
name: PIK3CG
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5294
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_b798f30d_f0a1_4871_be46_e6e0759c8761
constant: false
initial concentration: NaN
is encoded by: hsa:2645
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110038#_911da935_6c60_454d_87ee_f17e840d1149
is encoded by: hsa:2686
type: Species
name: GGT7
boundary condition: true
is: A0PJJ9
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM HC00342 m
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)
is: CHEBI:16383
initial amount: NaN
boundary condition: false
has only substance units: false

metaR AMANK
is version of: http://identifiers.org/ec-code/2.7.1.59
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: N-acetyl-D-mannosamine kinase

http://identifiers.org/biomodels.db/MODEL1310110038#_cff38958_6983_4048_833c_f391110bfd75
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:HG2846-HT2983
constant: false
initial amount: NaN
name: _HG2846_HT2983_1_m
type: Species
is: SBO:0000252

metaR FATP7t
fast: false
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is version of: http://identifiers.org/ec-code/6.2.1.7
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is: SBO:0000185
modifier: MODEL1310110038#

metaM ksi pre1 g
is: CHEBI:58053
type: Species
is: C00130
is: SBO:0000247
is: HMDB00175
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 1
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C79H129N5O57X CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110038#_09d2b057_fd06_4dba_a8b5_3d0121ee4808
initial amount: NaN
name: _AD000092_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:AD000092

http://identifiers.org/biomodels.db/MODEL1310110038#_afb71fb5_202b_4cd8_a37d_c614eac59a7b
name: OXSM
is encoded by: hsa:54995
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: Q9NWU1
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_6a32b5d4_c324_4d68_a6dc_b404a1da140c
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: ADH1B
boundary condition: true
is encoded by: hsa:125
type: Species
is: P00325
initial concentration: NaN

metaR r0829
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.1.1.37
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000

metaR r0946
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_f4fde8b8_d0b6_4354_acba_0a7b35ea8333
initial amount: NaN
boundary condition: true
name: AOC2
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:314
is: SBO:0000252
type: Species

metaM CE1926 e
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
type: Species
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
is: HMDB00127

metaR r2320
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR XOLTRIOLtm
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
name: lipid, flip-flop intracellular transport

metaR CYSSNAT5tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c7b9cbb7_b355_49ce_a9ea_e184020d9104
has only substance units: false
is: Q75T13
boundary condition: true
is encoded by: hsa:80055
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: PGAP1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_d55ee667_6464_4f45_a37a_38279e0e319c
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: Q92911
name: SLC5A5
has only substance units: false
is encoded by: hsa:6528
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_63afc168_53e7_44d1_ac27_5066061cd87a
initial concentration: NaN
is: Q5TDP6
constant: false
name: LGSN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:51557
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_d9ecc606_46d4_4fcd_ac71_48a1801791c4
boundary condition: true
is: SBO:0000252
name: PANK1
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:53354
has only substance units: false
constant: false

metaM uri c
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C00299
is: CHEBI:16704
name: Uridine
initial amount: NaN
constant: false
is: HMDB00296
initial concentration: 1.0

metaM dolmanp U c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Dolichyl phosphate D-mannose, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
type: Species
constant: false
is: SBO:0000247

metaR HISD
is version of: http://identifiers.org/ec-code/4.3.1.3
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
fast: false
reactant: MODEL1310110038#
name: histidase
reversible: false
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaM dcsptn1crn m
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06321
boundary condition: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM na1 x
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
constant: false
initial concentration: 1.0
is: HMDB00588
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:29101
name: sodium(1+)
boundary condition: false

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_feaf1c68_25d8_49b7_88bc_2c1f52b57216
initial amount: NaN
name: _AI091231_1_c
is: SBO:0000252
is encoded by: hsa:AI091231
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM c4dc c
is: C02862
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
constant: false
is: SBO:0000247
notes: FORMULA: C11H18NO6 CHARGE: -1
boundary condition: false
name: succinyl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_e30e7a69_c5f7_4a8e_b9ec_49292d7d72a0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: O75452
type: Species
name: RDH16
is encoded by: hsa:8608
constant: false

metaR C3STDH1Pr
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
fast: false
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
name: C-3 sterol dehydrogenase (4-methylzymosterol)
type: Reaction
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_7ee03b24_00b9_427e_b999_bf1fec2c97ff
constant: false
is: Q16739
is encoded by: hsa:7357
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: UGCG
has only substance units: false
type: Species

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_bc58146e_354b_403f_a113_65fde94f44d3
name: _AI373818_1_m
has only substance units: false
type: Species
is encoded by: hsa:AI373818
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM 3ddecdicoa x
constant: false
name: 3,6-dodecadienoylcoa
is: SBO:0000247
is: C05280
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: HMDB03952
initial amount: NaN

metaR KYNATESYN
product: MODEL1310110038#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110038#
fast: false
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000

metaM gal1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
constant: false
initial amount: NaN
is: HMDB00645
boundary condition: false
is: SBO:0000247
is: CHEBI:58336
type: Species
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_02080d28_6be5_4607_93f8_28b8558f72ea
is: SBO:0000297
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:498
has part: Q6I9V2
has only substance units: false
constant: false
has part: P25705
is encoded by: hsa:509
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaM dump c
is: SBO:0000247
boundary condition: false
name: dUMP
is: HMDB01409
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:246422
is: C00365
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

http://identifiers.org/biomodels.db/MODEL1310110038#_98f99e78_89f3_4fc9_90d8_058f10482aa4
initial amount: NaN
constant: false
is: SBO:0000252
is: Q5JRA6
is encoded by: hsa:375056
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: MIA3

metaM i c
boundary condition: false
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: SBO:0000247
is: CHEBI:16382
constant: false
initial concentration: 1.0
is: HMDB12238
name: iodide
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_119a742b_d3dc_4363_8011_5a49a0a1665c
initial concentration: NaN
name: _HG2846_HT2983_1_c
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:HG2846-HT2983
is: SBO:0000252

metaR PIt7
kinetic law: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
name: phosphate transport in/out via three Na+ symporter
reactant: MODEL1310110038#
fast: false
type: Reaction
product: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_d2df8034_a8d4_4a36_9e58_f86f29932cff
initial amount: NaN
has part: Q9UHI5
is encoded by: hsa:23428
boundary condition: true
initial concentration: NaN
is: SBO:0000297
constant: false
type: Species
has only substance units: false
name: SLC7A8:SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110038#_02989f3b_4c87_49dd_8549_0523642eccaf
initial concentration: NaN
is encoded by: hsa:5198
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: Q6P4B4
is: SBO:0000252
boundary condition: true
name: PFAS

http://identifiers.org/biomodels.db/MODEL1310110038#_1d5b3645_b6ce_4bb9_906b_4263cdde13bd
has only substance units: false
type: Species
is encoded by: hsa:6785
name: ELOVL4
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q9GZR5

http://identifiers.org/biomodels.db/MODEL1310110038#_bd588cb4_a465_4723_a30d_4341cfbf0050
is: Q9P1E4
has only substance units: false
is encoded by: hsa:4122
is: SBO:0000252
name: MAN2A2
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_a08751c2_7b60_4160_94d4_ee25027f3a2c
boundary condition: true
is encoded by: hsa:7371
initial concentration: NaN
is: Q9BZX2
has only substance units: false
name: UCK2
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaM i e
type: Species
constant: false
is: SBO:0000247
name: iodide
is: CHEBI:16382
initial concentration: 1.0
is: HMDB12238
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

metaM pydx5p c
type: Species
is: SBO:0000247
name: Pyridoxal 5'-phosphate
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: C00018
is: CHEBI:597326
initial amount: NaN
is: HMDB01491

http://identifiers.org/biomodels.db/MODEL1310110038#_407e5e5a_6af7_48f8_aee0_0d9dfa6dda4a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AA177072
constant: false
has only substance units: false
name: _AA177072_1_c
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_cde75451_0e40_46b7_b33c_4d5d67194a4d
constant: false
has only substance units: false
type: Species
name: SULT1A1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:6817
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_b5ec441b_9f03_45a4_8457_50ede9f66ba3
has only substance units: false
initial amount: NaN
is encoded by: hsa:30
initial concentration: NaN
is: Q96CA6
name: ACAA1
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR CYTK14
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110038#
name: cytidylate kinase (dCMP,UTP)
kinetic law: MODEL1310110038#
fast: false

metaR ACNAMPH
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
reversible: false
kinetic law: MODEL1310110038#

metaR PIt8
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter
is: SBO:0000185
type: Reaction
product: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000006
fast: false

metaM ipdp c
initial concentration: 1.0
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: HMDB01347
type: Species
is: C00129
is: CHEBI:128769
has only substance units: false
name: Isopentenyl diphosphate
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR HDDACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM udpacgal l
type: Species
is: HMDB00304
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
is: SBO:0000247
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false
initial amount: NaN
has only substance units: false

metaR GLNTHRNaEx
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: L-threonine/L-glutamine Na-dependent exchange (Gln-L in)
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR KSII CORE4t
reactant: MODEL1310110038#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: keratan sulfate II (core4) transport, golgi to extracellular
reversible: false
is described by: ECO:0000000

metaM C02528 c
is: SBO:0000247
constant: false
type: Species
name: chenodeoxycholate
is: HMDB00518
is: CHEBI:36234
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM HC00591 c
initial concentration: 1.0
boundary condition: false
name: 2-oxoglutaramate
type: Species
constant: false
is: SBO:0000247
is: CHEBI:16769
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

metaM 2hexdtricoa m
is: HMDB02288
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_7f5806fc_7f16_469b_8e99_cd7ef076d96e
is: Q9GZX3
is: SBO:0000252
name: CHST6
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:4166
initial concentration: NaN

metaR RPEc
type: Reaction
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
product: MODEL1310110038#
reactant: MODEL1310110038#
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_494bf502_2c1e_4bad_b0ab_42708c83d2d4
is: P11177
is: SBO:0000252
constant: false
is encoded by: hsa:5162
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: PDHB

metaR CYTK13
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110038#

metaR T4HCINNMFM
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
name: 4-hydroxycinnamate formation
reactant: MODEL1310110038#
type: Reaction
reversible: false

metaR S6T14g
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176

metaR PAPtg
name: adenosine 3',5'-bisphosphate Golgi transport
type: Reaction
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaM eicostet c
name: eicosatetranoic acid
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1
is: CHEBI:36033
is: HMDB02177
initial amount: NaN
has only substance units: false

metaM CE1617 r
boundary condition: false
name: 9-cis-retinoate
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01358
initial concentration: 1.0
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
is: CHEBI:17898

metaR FAOXC102x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaM ppi c
initial concentration: 1.0
is: HMDB00250
has only substance units: false
name: Diphosphate
is: C00013
is: SBO:0000247
is: CHEBI:0
notes: FORMULA: HO7P2 CHARGE: -3
initial amount: NaN
type: Species
boundary condition: false
constant: false

metaM ppi e
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
has only substance units: false
boundary condition: false
name: Diphosphate
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: C00013
initial concentration: 1.0
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110038#_c12f1794_9e46_4662_8c6d_88a90d14f6f4
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:3081
is: Q93099
constant: false
name: HGD
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM strch2 e
constant: false
is: HMDB00122
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H32O16 CHARGE: 0
is: SBO:0000247
is: CHEBI:4167
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
has only substance units: false
initial concentration: 1.0
type: Species

metaM sgalside hs c
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN
constant: false
is: HMDB03406
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: sulfatide galactocerebroside
has only substance units: false
is: CHEBI:16523

http://identifiers.org/biomodels.db/MODEL1310110038#_7da7060e_9b8e_4dba_b9b1_416015968c2e
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: O94777
is: SBO:0000252
is encoded by: hsa:8818
type: Species
boundary condition: true
constant: false
name: DPM2

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM idour e
name: L-iduronate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02704
type: Species
is: CHEBI:21338
constant: false

metaM pydx5p e
is: SBO:0000247
type: Species
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
constant: false
initial concentration: 1.0
is: CHEBI:597326
has only substance units: false
initial amount: NaN
boundary condition: false
name: pyridoxal 5'-phosphate(2-)
is: HMDB01491

http://identifiers.org/biomodels.db/MODEL1310110038#_de74692f_842e_4d37_982b_fc1c87a89c26
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: O15357
is encoded by: hsa:3636
is: SBO:0000252
has only substance units: false
name: INPPL1

metaR CYTK12
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110038#
is described by: ECO:0000269
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_f372ef25_4e5e_456c_9416_6b9ff103809a
name: MAT2B
constant: false
is encoded by: hsa:27430
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_d8175d5c_07fb_4fe2_a8fb_6f04ef284432
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10005
constant: false
is: SBO:0000252
is: O14734
name: ACOT8
boundary condition: true
initial amount: NaN

metaM 3ivcrn c
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
is: SBO:0000247
name: 3-hydroxy-isovaleryl carnitine
boundary condition: false
initial concentration: 1.0
is: C05998
notes: FORMULA: C12H23NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110038#_70283546_1a51_482a_bd37_6b7d2df2c04c
constant: false
boundary condition: true
is: Q07326
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5281
type: Species
name: PIGF

metaM dhdascb c
is: CHEBI:58070
initial concentration: 1.0
is: HMDB01264
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
name: dehydroascorbide(1-)

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_7bb0f7a4_973c_47e3_bb4e_3023589b7261
has only substance units: false
boundary condition: true
name: GPX2
is encoded by: hsa:2877
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P18283
constant: false
type: Species

metaR 3HLYTCL
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000269
reversible: false
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
is: SBO:0000176
fast: false
name: 3-Hydroxy-L-tyrosine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28

http://identifiers.org/biomodels.db/MODEL1310110038#_3da164b9_7401_4068_b6a7_6d3302c204bf
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC22A2
constant: false
is: O15244
is encoded by: hsa:6582
initial concentration: NaN
type: Species

metaM mi34p c
name: 1D-myo-Inositol 3,4-bisphosphate
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:28858
is: HMDB06235
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063

metaM gsn c
is: SBO:0000247
is: C00387
initial amount: NaN
is: CHEBI:16750
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
name: Guanosine
initial concentration: 1.0
type: Species

metaM glac r
is: CHEBI:18268
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: D-glucurono-6,3-lactone
type: Species
is: HMDB06355
constant: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
boundary condition: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM dlnlcgcrn m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine
constant: false
is: HMDB01311
is: CHEBI:16004
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
has only substance units: false
type: Species

metaR FACOAL226
type: Reaction
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110038#
name: fatty-acid--CoA ligase

metaR r0426
fast: false
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is: SBO:0000176
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.1.34

metaM hxcoa m
type: Species
is: HMDB06522
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Hexanoyl-CoA (n-C6:0CoA)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false

metaR FAOXC11
reversible: false
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
modifier: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR TRDRm
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.8.1.9
fast: false
product: MODEL1310110038#
modifier: MODEL1310110038#
name: thioredoxin reductase (NADPH)
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD

metaR r0281
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6
reactant: MODEL1310110038#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
modifier: MODEL1310110038#
reversible: true
product: MODEL1310110038#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
type: Reaction

metaM apoC m
is: CHEBI:32551
initial amount: NaN
constant: false
notes: FORMULA: XH CHARGE: 0
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Apocarboxlase (no lys residue)
type: Species
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110038#_b35f581d_c6be_4362_a98c_5a124a8e3deb
initial amount: NaN
has only substance units: false
is: Q2TU34
is: SBO:0000252
name: FBP1
constant: false
is encoded by: hsa:2203
type: Species
initial concentration: NaN
boundary condition: true

metaR H4ETer
is described by: ECO:0000000
fast: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cd56956d_e40f_4511_b162_f7b95820bc9f
name: NADSYN1
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55191
initial amount: NaN
type: Species
is: Q6IA69

http://identifiers.org/biomodels.db/MODEL1310110038#_aa867058_11ea_4c6d_a29b_b0592e475c25
type: Species
boundary condition: true
constant: false
has only substance units: false
is: Q969K7
name: TMEM54
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:113452

http://identifiers.org/biomodels.db/MODEL1310110038#_9c7f0f55_4b85_49a4_aa9d_e604a03516c9
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:30
boundary condition: true
initial amount: NaN
name: ACAA1
initial concentration: NaN
is: Q96CA6
constant: false

metaM ksi deg11 l
boundary condition: false
is: HMDB00143
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 11
has only substance units: false
type: Species
initial concentration: 1.0

metaR 3SALAASPm
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
name: cysteinesulfinate-aspartate mitochondrial shuttle
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000304
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaR TTDCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110038#
name: carnitine transferase
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110038#

metaR THMPPtm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
name: Thiamine diphosphate transport in via anion antiport, mitochondria

http://identifiers.org/biomodels.db/MODEL1310110038#_0f1b8af8_55f4_4977_a318_2dacf08e560e
is: P04035
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: HMGCR
is encoded by: hsa:3156

http://identifiers.org/biomodels.db/MODEL1310110038#_1b72e28b_b184_48db_9b7b_aa1663c24df2
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q96H96
initial concentration: NaN
is encoded by: hsa:27235
type: Species
has only substance units: false
name: COQ2

metaR R group phosphotase 1
kinetic law: MODEL1310110038#
reversible: false
name: R group phosphotase 1
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:

metaR CYSO
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
is described by: ECO:0000269
type: Reaction
name: cysteine oxidase
reactant: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.13.11.20
fast: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM dhdascb e
type: Species
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
name: dehydroascorbide(1-)
is: HMDB01264
is: SBO:0000247
is: CHEBI:58070

metaM 3ivcrn e
constant: false
has only substance units: false
is: HMDB13336
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H23NO5 CHARGE: 0
name: 3-hydroxy-isovaleryl carnitine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_862f819e_7282_431a_89e1_ed6355dd1208
is: Q6NVY1
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:26275
initial concentration: NaN
name: HIBCH
is: SBO:0000252

metaM acmanap c
initial amount: NaN
boundary condition: false
is: HMDB01121
type: Species
name: N-acetyl-D-mannosamine 6-phosphate(2-)
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:58557

http://identifiers.org/biomodels.db/MODEL1310110038#_e5eb519b_32e1_4127_b138_b450dbf88001
constant: false
name: ECI1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1632
initial concentration: NaN
has only substance units: false
is: P42126
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_0ea8a532_4cc1_48ea_9bf9_75d567ad07ff
has only substance units: false
type: Species
boundary condition: true
constant: false
is: Q6ZWP6
initial amount: NaN
initial concentration: NaN
name: ACAD8
is encoded by: hsa:27034
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_0a0adf89_2cd4_4393_91d9_03510aafaece
has only substance units: false
constant: false
initial amount: NaN
name: AK2
initial concentration: NaN
type: Species
boundary condition: true
is: P54819
is encoded by: hsa:204
is: SBO:0000252

metaR C101CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_5358a010_6a35_44a8_b624_56c789ab7768
initial amount: NaN
is encoded by: hsa:114
name: ADCY8
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q4F7X0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_76394426_d26b_4df4_9eb6_ee9dfc75424e
name: DHCR24
is: SBO:0000252
boundary condition: true
is: Q15392
has only substance units: false
constant: false
is encoded by: hsa:1718
initial concentration: NaN
type: Species
initial amount: NaN

metaR TTDCPT1
reactant: MODEL1310110038#
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
product: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction

metaR RE3006M
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110038#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
reactant: MODEL1310110038#
modifier: MODEL1310110038#

metaM gsn e
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:16750
is: HMDB00133
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
name: Guanosine
is: C00387

metaR R group phosphotase 2
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
name: R group phosphotase 2

http://identifiers.org/biomodels.db/MODEL1310110038#_50c12a29_689e_4f8b_87da_abf1c63f548c
type: Species
is: P00918
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:760
name: CA2

metaM ksi deg2 l
boundary condition: false
has only substance units: false
is: CHEBI:50570
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: HMDB06529
initial amount: NaN
name: keratan sulfate I, degradation product 2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_5d04058d_c375_4a45_af8a_c93379d6fbca
constant: false
has only substance units: false
is: SBO:0000297
has part: B4E3E9
type: Species
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r0403
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
modifier: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#

metaM HC00591 m
has only substance units: false
name: 2-oxoglutaramate
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
is: CHEBI:16769

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_f770c978_d3f5_498a_9c14_6a36d20375b3
initial concentration: NaN
name: SLC5A9
type: Species
is: E9PAK4
is encoded by: hsa:200010
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR FAOXC225C226x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR 4MPTNLte
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
name: 4-methylpentanal transport
is: SBO:0000185
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_de7ca3a3_2632_4b3b_87cf_fb4a8b9b2076
is: Q96A70
constant: false
is encoded by: hsa:113451
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ADC
initial amount: NaN
type: Species
boundary condition: true

metaR RE0344C
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110038#
reversible: true
name: RE0344
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:

metaR r0139
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110038#_a548d3fe_bc1f_4b6e_a15f_30fffd59c77e
type: Species
initial amount: NaN
is: Q56NI9
has only substance units: false
is encoded by: hsa:157570
is: SBO:0000252
initial concentration: NaN
name: ESCO2
boundary condition: true
constant: false

metaR CYSALANaEx
name: L-alanine/L-cysteine Na-dependent exchange (Cys-L in)
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c8e88dfa_57f0_42f0_9521_3b89c04e0b9d
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:51196
type: Species
is: Q9P212
initial concentration: NaN
name: PLCE1
has only substance units: false

metaM urcan c
is: C00785
is: CHEBI:17771
is: HMDB00301
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_99e736c8_593f_4212_a267_1e6d5c4d9f02
is: Q9UBF8
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: PI4KB
is encoded by: hsa:5298
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0660eca8_f67b_4841_99b4_f74e5becbbf4
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4706
initial concentration: NaN
is: SBO:0000252
name: NDUFAB1
is: O14561
constant: false

metaM 4mptnl m
constant: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
is: HMDB01318
has only substance units: false
name: 4-methylpentanal
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17998

metaR R group phosphotase 3
name: R group phosphotase 3
reversible: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000000

metaM mi14p n
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: SBO:0000247
is: CHEBI:58282
is: HMDB00968
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaR NDPK4n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is described by: ECO:0000304
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_bf64eb9f_b1b7_4efd_b2fd_6f51d0ab0d80
constant: false
type: Species
name: NDUFC2
initial concentration: NaN
is: Q549M5
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4718
initial amount: NaN

metaR GALASE6ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110038#
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r0408
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11

metaM ksii core2 pre8 g
initial amount: NaN
has only substance units: false
is: C00130
constant: false
boundary condition: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 8
is: CHEBI:58053
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_8bdd9f8d_8926_447b_8dbc_8619e96ee07f
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000297
is encoded by: hsa:516
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6FIH7

metaM ha deg1 l
is: CHEBI:16336
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: hyaluronan degradation product 1
has only substance units: false
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaM arab L c
notes: FORMULA: C5H10O5 CHARGE: 0
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: L-arabinose
has only substance units: false
is: HMDB00646
is: CHEBI:30849

http://identifiers.org/biomodels.db/MODEL1310110038#_41a5db07_4109_4e98_b739_e9f848ba07fd
name: TSTA3
is encoded by: hsa:7264
boundary condition: true
constant: false
is: Q13630
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM dhbpt c
is: CHEBI:20680
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
boundary condition: false
is: HMDB00038
is: SBO:0000247
name: 6,7-dihydrobiopterin
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false

metaR SGALSIDEtl
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
fast: false
name: sgalside hs intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_e7cfc2f0_7873_451b_876e_2478a8570b91
is encoded by: hsa:480
has only substance units: false
is: SBO:0000252
name: ATP1A4
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q13733

http://identifiers.org/biomodels.db/MODEL1310110038#_7389d716_077f_46d0_9386_ca407512444e
is: P17568
name: NDUFB7
is encoded by: hsa:4713
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_49ae42d9_5188_4bbd_a690_6c1b3440afdf
name: NMNAT2
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23057
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_00e14ccb_f996_4262_ba9f_a54a3b8a22c3
type: Species
boundary condition: true
initial concentration: NaN
is: Q9UBF8
name: PI4KB
is encoded by: hsa:5298
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR PDHm
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.12
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
name: pyruvate dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.1

metaR GAPD
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reactant: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.12
type: Reaction
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
product: MODEL1310110038#

metaR PROSTGF2t
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport

metaR r0409
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.10
reactant: MODEL1310110038#
reversible: true
fast: false
type: Reaction
is: SBO:0000176

metaM xoldiolone c
is: HMDB02197
is: CHEBI:28477
type: Species
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_3cb699a1_a514_4dc7_a6b4_25ec04266188
type: Species
is encoded by: hsa:1103
boundary condition: true
is: D3DX95
name: CHAT
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_440731eb_6efa_4d82_abf1_1b106f7c34d0
initial concentration: NaN
type: Species
is encoded by: hsa:4726
name: NDUFS6
boundary condition: true
has only substance units: false
is: Q6IBC4
constant: false
is: SBO:0000252
initial amount: NaN

metaM odecoa r
is: SBO:0000247
is: CHEBI:57387
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
is: HMDB01322
initial concentration: 1.0
boundary condition: false
name: oleoyl-CoA(4-)
type: Species
initial amount: NaN

metaM dcmp c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00239
is: HMDB01202
has only substance units: false
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP
type: Species
is: CHEBI:57566
initial amount: NaN

metaM dgchol x
has only substance units: false
initial amount: NaN
name: glycochenodeoxycholate
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
is: HMDB00637
constant: false
type: Species
boundary condition: false
is: CHEBI:36252

metaR C4STMO1r
type: Reaction
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
fast: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
is: SBO:0000176
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.13.72
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_0bb235f5_32cf_498d_823d_110fd2fb00c1
type: Species
is encoded by: hsa:491
constant: false
name: ATP2B2
boundary condition: true
has only substance units: false
is: Q4J699
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM cholcoa x
initial amount: NaN
initial concentration: 1.0
is: HMDB01374
type: Species
name: choloyl-CoA(4-)
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
constant: false
is: CHEBI:57373
is: SBO:0000247
boundary condition: false

metaR FACOAL224
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
name: fatty-acid--CoA ligase
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

metaR ACGALtly
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
fast: false
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: N-acetyl-galactosamine lysosomal efflux
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction

metaM co c
has only substance units: false
name: carbon monoxide
is: CHEBI:17245
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01361
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: SBO:0000247
initial amount: NaN

metaR FAOXC9C7m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
has only substance units: false
name: keratan sulfate I, degradation product 30
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:12936

metaR r0287
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110038#
fast: false
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR EX c5dc
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM hmgcoa m
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01375
initial concentration: 1.0
type: Species
constant: false

metaR FMNAT
reversible: false
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
fast: false
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.2

http://identifiers.org/biomodels.db/MODEL1310110038#_f51db8aa_b76e_479e_9a4f_37caa04f78e0
is: P07195
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:3945
has only substance units: false
name: LDHB
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_d71845ae_37e6_4eb8_9234_a08d68952248
is encoded by: hsa:51166
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: Q8N5Z0
name: AADAT
initial concentration: NaN
boundary condition: true
constant: false

metaR FAOXC162C162OHm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaR ECOAH1m
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110038#
is described by: ECO:0000304
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18

metaM g3m8masn r
boundary condition: false
is: SBO:0000247
is: C05873
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C88H147N2O70X CHARGE: 0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r0407
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
fast: false
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is described by: ECO:0000000
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: true
is: SBO:0000176

metaR UDPtl
is: SBO:0000185
reversible: true
name: udp intracellular transport
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
type: Reaction
product: MODEL1310110038#

metaR FAOXC226C225x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR COQ3m
product: MODEL1310110038#
modifier: MODEL1310110038#
name: methyltransferase COQ3
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.114
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction

metaR EX c16dc
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

metaM mal L e
initial amount: NaN
name: (S)-malate(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00156
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false
is: CHEBI:15589
constant: false

metaR CITtbm
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
name: citrate transport, mitochondrial
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
is: SBO:0000185
reactant: MODEL1310110038#

metaM ksi deg32 l
initial amount: NaN
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
has only substance units: false
is: HMDB00143
type: Species
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 32
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_da601a63_d47b_4d43_b927_04a1118ddd6d
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has part: Q06055
constant: false
type: Species
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:517

metaR SERtN1
modifier: MODEL1310110038#
name: Serine transport (Na, H coupled)
is: SBO:0000185
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
reactant: MODEL1310110038#
type: Reaction

metaR C10DCCACT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_8fec77cb_04c6_49d8_a768_c43d91b20cfa
is encoded by: hsa:123041
is: SBO:0000252
has only substance units: false
name: SLC24A4
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_a663099a_941c_4f9a_9f29_c612d859b931
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4952
name: OCRL

metaR VLCS2r
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000304
product: MODEL1310110038#
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaM orn m
type: Species
is: C01602
is: SBO:0000247
has only substance units: false
is: HMDB00214
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
is: CHEBI:46912
name: Ornithine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_3a7bc3fd_cee1_4271_934e_3f9024edcec7
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P15328
initial amount: NaN
constant: false
name: FOLR1
is: SBO:0000252
type: Species
is encoded by: hsa:2348

metaR PTPATe
is: SBO:0000176
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: PTPATe
is described by: ECO:0000134
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true

metaM acnamp c
name: N-Acetylneuraminate 9-phosphate
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
initial concentration: 1.0
type: Species
is: HMDB06268
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:27438
is: SBO:0000247

metaM Rtotal c
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false
is: SBO:0000247
is: CHEBI:16189
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: R total
constant: false
is: HMDB01448

metaM docohexcoa m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790

metaR EX 3ddcrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaR FAOXC225C226m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR P4501B1r
type: Reaction
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
name: cytochrome P450 1B1
fast: false
modifier: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.14.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_460ed390_c6f6_4514_8ebf_6219434027c8
name: _T83654_1_m
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:T83654

metaR M8MASNterg
reactant: MODEL1310110038#
is: SBO:0000185
name: m8masn transport from ER to Golgi apparatus
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD
product: MODEL1310110038#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9878f512_2336_4e89_9c30_417e452633b1
type: Species
is: P36269
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2687
name: GGT5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_48694ea4_dcf0_4122_b3e5_159eec25afd1
constant: false
is: Q99807
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: COQ7
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10229

metaM mal L c
is: SBO:0000247
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00156
is: CHEBI:15589

http://identifiers.org/biomodels.db/MODEL1310110038#_4c1bb356_0aa8_43a7_a0b2_b1b642158daa
boundary condition: true
initial concentration: NaN
is: Q9NY64
has only substance units: false
is encoded by: hsa:29988
name: SLC2A8
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

metaM cmpacna c
is: SBO:0000247
constant: false
is: CHEBI:57812
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01176

metaM dlnlcgcrn c
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine
initial concentration: 1.0
has only substance units: false
is: HMDB01311
is: CHEBI:16004
initial amount: NaN
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_7810bae1_cc6e_4e9b_9ffa_1a8e11cfb5df
is: P49915
initial concentration: NaN
type: Species
name: GMPS
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:8833
boundary condition: true
has only substance units: false

metaR PRODt2r
reactant: MODEL1310110038#
is described by: ECO:0000304
reversible: true
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
type: Reaction
name: D-proline reversible transport via proton symport
is: SBO:0000185

metaR ASPDTDe
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
reactant: MODEL1310110038#
name: D-aspartate transport, extracellular
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaR BAAT3x
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
modifier: MODEL1310110038#
is described by: ECO:0000304
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_15ef9946_9b3f_4995_9b8a_191771117803
is encoded by: hsa:55
is: P15309
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: ACPP
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_b573c3fb_4b60_474c_906d_88138024f6bd
is: Q9HBF5
is: SBO:0000252
is encoded by: hsa:400410
initial concentration: NaN
constant: false
name: ST20
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaM cholcoads x
type: Species
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
initial concentration: 1.0
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
constant: false
is: HMDB06889
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:27505

http://identifiers.org/biomodels.db/MODEL1310110038#_64d271f0_e487_4a62_9522_a0656fd85faf
name: _AA081045_1_e
type: Species
initial concentration: NaN
is encoded by: hsa:AA081045
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1863676e_a0af_41f4_a1e0_bdf8a0af2aa4
is encoded by: hsa:3251
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: HPRT1
is: P00492
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_72bf524e_e354_49c8_b93a_2a8cb3591df4
type: Species
constant: false
is: SBO:0000252
name: PLCZ1
is: Q86YW0
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:89869

metaM tdcrn c
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: myristoyl carnitine
constant: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0
is: HMDB05066
initial concentration: 1.0

metaR 5OXPROt
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
name: Transport of 5-oxoprolinate
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_b1176a46_4c0b_45b4_93a2_4f8e9c27d23b
is encoded by: hsa:222
is: SBO:0000252
is: P48448
initial amount: NaN
has only substance units: false
name: ALDH3B2
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR 4MPTNLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
type: Reaction
name: 4-methylpentanal transport (mitochondria)
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000

metaM Rtotal e
type: Species
is: C00255
boundary condition: false
constant: false
initial amount: NaN
name: R total
initial concentration: 1.0
is: SBO:0000247
is: HMDB00244
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:3554
has only substance units: false

metaR STRDNCCOAtxc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of stearidonylcoa into peroxisomes.
type: Reaction

metaR FAOXC184C163x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR DNDPt37m
name: dUTP transport via dTDP antiport
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110038#
is: SBO:0000185

metaM r5p r
constant: false
is: CHEBI:18189
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00618
boundary condition: false
name: alpha-D-Ribose 5-phosphate
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
type: Species

metaM apoC c
boundary condition: false
name: Apocarboxlase (no lys residue)
type: Species
is: SBO:0000247
is: HMDB11111
notes: FORMULA: XH CHARGE: 0
is: CHEBI:33190
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM arab L e
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0
is: SBO:0000247
constant: false
is: HMDB00646
is: CHEBI:30849
initial concentration: 1.0
initial amount: NaN
type: Species
name: L-arabinose
has only substance units: false

metaM cspg a l
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: CHEBI:36005
is: HMDB02183
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c595312f_4c4d_4b93_8853_5f60f6bcbffa
type: Species
is: SBO:0000252
constant: false
is: O00746
initial amount: NaN
is encoded by: hsa:4833
boundary condition: true
has only substance units: false
initial concentration: NaN
name: NME4

metaM 4mptnl e
type: Species
boundary condition: false
is: CHEBI:17998
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: HMDB01318
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 4-methylpentanal

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM phyt e
name: phytanate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
constant: false
is: CHEBI:37257
type: Species
is: HMDB00801
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_28e0a669_0c6e_42e7_9373_6404e5934053
constant: false
initial amount: NaN
has part: Q53G02
has part: P04844
boundary condition: true
is encoded by: hsa:6184
type: Species
has only substance units: false
has part: P39656
is encoded by: hsa:6185
name: DAD1:DDOST:RPN1:RPN2
initial concentration: NaN
is encoded by: hsa:1603
has part: P04843
is: SBO:0000297
is encoded by: hsa:1650

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d9c33f84_a314_4dcb_aabc_e3aa1a083e8d
boundary condition: true
initial amount: NaN
is encoded by: hsa:3030
is: E9KL44
name: HADHA
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM c4crn x
is: SBO:0000247
name: butyryl carnitine
is: C02862
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02013
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
constant: false

metaM ocdcea e
name: octadecenoate (n-C18:1)
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: C00712
is: HMDB00207
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110038#_34faa87a_989c_45a2_b9ee_8a2dd8589d45
is: O95861
initial amount: NaN
constant: false
is encoded by: hsa:10380
type: Species
name: BPNT1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR MM8Cg
product: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110038#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110038#_4e0c8a3a_4d52_4be2_b71d_d352b9f3e2b9
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: _C7orf24_1_m
is encoded by: hsa:C7orf24

http://identifiers.org/biomodels.db/MODEL1310110038#_ee646c1a_c5c9_4507_8086_4783d8134d75
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_0e62d81f_b9c2_47f6_af41_b792480f63bf
constant: false
initial amount: NaN
has only substance units: false
name: _AF080579_1_c
is encoded by: hsa:AF080579
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_44954038_273c_4a0b_9ca4_9848c2e0b290
initial concentration: NaN
is encoded by: hsa:N63787
boundary condition: true
constant: false
has only substance units: false
type: Species
name: _N63787_1_c
initial amount: NaN
is: SBO:0000252

metaR INSTt2r
product: MODEL1310110038#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110038#
name: inositol transport in via proton symport

metaM tdcrn e
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
name: myristoyl carnitine
is: HMDB05066
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110038#_4ac63ea8_cab7_4490_91d4_e2ee4ed98658
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: PECR
type: Species
is: Q9BY49
is encoded by: hsa:55825
initial concentration: NaN
boundary condition: true

metaM g1m8mpdol U r
boundary condition: false
initial amount: NaN
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
is: CHEBI:59093
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_85c6ce95_5615_4520_914e_7822178a4b18
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:22305
initial amount: NaN
constant: false
initial concentration: NaN
name: _22305_2_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_076a481f_70d8_44da_8e21_55a1f0468fae
boundary condition: true
is: P04075
initial amount: NaN
is encoded by: hsa:226
name: ALDOA
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaM hLkynr c
is: CHEBI:17380
is: SBO:0000247
constant: false
boundary condition: false
name: 3-hydroxy-L-kynurenine
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
type: Species
is: HMDB11631
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR C160CRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: false
reactant: MODEL1310110038#
type: Reaction
name: C160 transport into the mitochondria
is described by: ECO:0000269
modifier: MODEL1310110038#
product: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_48284f32_e871_4344_a10c_045abd03cbb2
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3948
is: P07864
name: LDHC
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_4ca6e50e_8ceb_4c39_b640_d180397ba29f
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:AI024818
boundary condition: true
initial concentration: NaN
name: _AI024818_1_c

http://identifiers.org/biomodels.db/MODEL1310110038#_aa8f2993_f133_4bfe_91a0_fefce2bbd27f
type: Species
has only substance units: false
name: PANK2
is encoded by: hsa:80025
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM adpac x
is: SBO:0000247
is: HMDB00448
type: Species
boundary condition: false
constant: false
name: adipic acid
initial concentration: 1.0
notes: FORMULA: C6H8O4 CHARGE: -2
initial amount: NaN
has only substance units: false

metaR DOPASULT
reversible: false
modifier: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
is described by: ECO:0000269
product: MODEL1310110038#
type: Reaction
fast: false
name: Dopamine Sulfotransferase

metaR TTDCAtr
product: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
name: tetradecanoate (transport)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_418f86d6_ccae_467c_b9cd_517925474481
is: SBO:0000252
name: GCNT3
is encoded by: hsa:9245
type: Species
boundary condition: true
is: O95395
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR DITPtn
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dITP nuclear transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: true

metaR HPDCAt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110038#
reactant: MODEL1310110038#
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110038#

metaM phyt c
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:37257
type: Species
boundary condition: false
has only substance units: false
is: HMDB00801

metaM glac c
constant: false
is: HMDB06355
name: D-glucurono-6,3-lactone
has only substance units: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
type: Species
is: CHEBI:18268
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM lneldccrn c
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB06461
name: Linoelaidyl carnitine

metaR SGALSIDEtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: sgalside hs intracellular transport
fast: false
reactant: MODEL1310110038#
reversible: true
is: SBO:0000185
product: MODEL1310110038#

metaM 2octpencoa m
initial amount: NaN
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: 2,6,9,12,15-octadecapentenoylcoa
type: Species
initial concentration: 1.0

metaM ksi deg17 l
has only substance units: false
constant: false
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
name: keratan sulfate I, degradation product 17
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
type: Species
boundary condition: false

metaM sebacid x
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
has only substance units: false
is: C08277
boundary condition: false
name: sebacicacid
is: SBO:0000247
is: HMDB00792

http://identifiers.org/biomodels.db/MODEL1310110038#_f2b471c2_ace6_4ca4_9fdc_7d2fc0a2277b
name: NME1
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P15531
is encoded by: hsa:4830
initial amount: NaN
initial concentration: NaN
type: Species

metaR ACOAO7p
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#

metaR CERT1gt
reactant: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
type: Reaction
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true

metaM cmpacna g
type: Species
is: HMDB01176
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57812
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0

metaM ocdcea c
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
is: HMDB00207

http://identifiers.org/biomodels.db/MODEL1310110038#_7148c104_70ba_4dc3_8aa2_e9c56159b910
is: SBO:0000252
has only substance units: false
is encoded by: hsa:64080
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: Q9H477
name: RBKS

metaR LINKDEG4ly
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR N2M2NMASNtly
reactant: MODEL1310110038#
product: MODEL1310110038#
name: n2m2nmasn transport, extracellular to lysosome
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: false

metaM doco13ac e
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: docosenoic acid (C22:1)
is: SBO:0000247
is: HMDB02068
initial concentration: 1.0
notes: FORMULA: C22H41O2 CHARGE: -1
boundary condition: false

metaR VLCS2p
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176

metaM 12ppd S c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
constant: false
is: HMDB06213
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (S)-propane-1,2-diol
has only substance units: false
is: CHEBI:29002
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_aa0c8352_b085_4904_ad1a_d692021eb904
constant: false
initial concentration: NaN
name: DGKD
boundary condition: true
has only substance units: false
is: Q16760
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8527
type: Species

metaR NADtx
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: transport of NAD into peroxisome

metaR OCD11CRNCPT2
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_495ab449_5283_4322_a891_24ef8e809661
name: GPI
is: P06744
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2821
type: Species

metaM cbasp e
type: Species
notes: FORMULA: C5H6N2O5 CHARGE: -2
initial concentration: 1.0
boundary condition: false
is: CHEBI:32814
is: C00438
is: SBO:0000247
is: HMDB00828
name: N-Carbamoyl-L-aspartate
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_4300471e_fc6c_4aa3_a800_e80636d70c7a
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM gluside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: D-glucosyl-N-acylsphingosine
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM ksi deg26 l
constant: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 26
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
boundary condition: false
is: HMDB00061
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58343

metaM etfox m
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16469
constant: false
has only substance units: false
initial concentration: 1.0
name: Electron transfer flavoprotein oxidized
is: HMDB00151
type: Species
notes: FORMULA: R CHARGE: 0

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_cd207717_6b1d_479f_a124_cf4cfe558312
initial amount: NaN
has only substance units: false
is: O60503
boundary condition: true
is: SBO:0000252
type: Species
name: ADCY9
is encoded by: hsa:115
constant: false
initial concentration: NaN

metaR PHEACGLNt
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
name: PHEACGLN extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_9a26b6f8_b183_49b9_8822_e3abe9a9cdac
name: GBA
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:2629
is: P04062
type: Species
initial concentration: NaN

metaM cspg a e
is: CHEBI:17568
initial amount: NaN
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: HMDB00300
boundary condition: false
constant: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
has only substance units: false
type: Species
is: SBO:0000247
is: C00106

metaM q10h2 c
has only substance units: false
is: HMDB13111
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
type: Species
constant: false
name: Ubiquinol-10

metaR SBT Dtde
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110038#
name: D-sorbitol transport, extracellular
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
fast: false

metaM ttdcrn c
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
is: HMDB05066
is: http://identifiers.org/pubchem.compound/3413344
constant: false
initial amount: NaN
has only substance units: false
name: tetradecanoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110038#_22ce8d32_7ec0_4cbb_bbc1_79bd65a04a9a
initial amount: NaN
boundary condition: true
is: Q99944
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: EGFL8
constant: false
type: Species
is encoded by: hsa:80864

metaR PPDOy
reversible: false
reactant: MODEL1310110038#
product: MODEL1310110038#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110038#

metaM dcholcoa c
type: Species
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28701
initial concentration: 1.0
is: HMDB06292
is: SBO:0000247
has only substance units: false

metaM orn e
is: CHEBI:0
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: HMDB00214
is: C01602
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: Ornithine
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_6f59c38c_166f_4a2e_bcc4_03ff04200d18
initial concentration: NaN
boundary condition: true
constant: false
is: Q99808
type: Species
has only substance units: false
is encoded by: hsa:2030
initial amount: NaN
is: SBO:0000252
name: SLC29A1

metaR PGLer
fast: false
reversible: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is described by: ECO:0000269
is: SBO:0000176

metaM 2decdicoa x
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
type: Species
name: 2,7-decadienoylcoa
has only substance units: false
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_84ded92e_bf15_4140_a57c_7cf70b2e3dc0
is: Q5JPH6
has only substance units: false
is encoded by: hsa:124454
initial concentration: NaN
boundary condition: true
name: EARS2
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_020f4ce0_9e7e_4fb7_85ea_7321a2330837
is encoded by: hsa:54898
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9NXB9
is: SBO:0000252
initial amount: NaN
name: ELOVL2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_461c30ac_2165_4146_8483_f96be2eb8a67
is encoded by: hsa:6582
constant: false
name: SLC22A2
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM hmgcoa x
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:15467
type: Species
is: HMDB01375

http://identifiers.org/biomodels.db/MODEL1310110038#_adf79fed_3634_4f62_a42f_ccaa4dec0390
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _LOC647190_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:LOC647190
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_083387cd_9f70_4f48_a141_4ceae349334e
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q9H008
name: LHPP
is encoded by: hsa:64077

metaR PPDOx
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase

metaR DOLGLCP Uter
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
product: MODEL1310110038#

metaM ksi pre33 g
constant: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: HMDB00175
initial amount: NaN
boundary condition: false
is: C00130
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 33
initial concentration: 1.0

metaR HGNTOR
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110038#
reversible: false
fast: false
kinetic law: MODEL1310110038#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR THRALANaEx
reactant: MODEL1310110038#
name: L-alanine/L-threonine Na-dependent exchange (Thr-L in)
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_a3b6c172_699c_408a_8d96_d31532da4920
has only substance units: false
initial amount: NaN
name: PIP4K2B
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: P78356
is encoded by: hsa:8396

http://identifiers.org/biomodels.db/MODEL1310110038#_d05c4dfb_cfd0_48db_8efd_6cfe4a84db6c
is: Q15147
constant: false
has only substance units: false
initial concentration: NaN
name: PLCB4
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5332
boundary condition: true
type: Species

metaR r0130
reactant: MODEL1310110038#
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110038#

metaM cbasp c
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
is: C00438
name: N-Carbamoyl-L-aspartate
is: SBO:0000247
has only substance units: false
is: HMDB00828
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_2ec11194_cf3b_4cf2_918a_691ff4f5f042
initial concentration: NaN
type: Species
initial amount: NaN
name: ALDH4A1
has only substance units: false
is: P30038
boundary condition: true
constant: false
is encoded by: hsa:8659
is: SBO:0000252

metaR EX tetdece1crn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_27016834_0ba9_42dc_aa7b_c81f003d9195
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:30833
type: Species
name: NT5C
is: Q8TCD5

metaM 2octdectecoa x
name: 2,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM sebacid c
is: HMDB00792
constant: false
has only substance units: false
name: sebacicacid
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C08277

metaM 3oddcoa m
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB03937
boundary condition: false
initial amount: NaN
name: 3-Oxododecanoyl-CoA
is: CHEBI:27868
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263

metaR r0975
is described by: ECO:0000000
name: Facilitated diffusion
is: SBO:0000185
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d7c3e4cd_abf0_4726_9de1_5f046c1fd63b
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:7001
is: P32119
initial concentration: NaN
is: SBO:0000252
name: PRDX2
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_4ac4dfe7_b1ae_4bb8_98c3_33e649f03e4a
is: P36969
initial concentration: NaN
is: SBO:0000252
type: Species
name: GPX4
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110038#_ef153019_4eae_40e1_a6cf_fbd465cc5d93
initial amount: NaN
is: Q5MY95
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:377841
is: SBO:0000252
has only substance units: false
name: ENTPD8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_8c5f26d6_b232_4d94_95ac_b8b7d05c7c15
is: G3V4L5
constant: false
boundary condition: true
name: SLC25A21
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:89874
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_8e14926b_8619_48b8_8858_cb1d84ea595c
is: Q86V21
has only substance units: false
boundary condition: true
name: AACS
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:65985

http://identifiers.org/biomodels.db/MODEL1310110038#_3f0e62f3_05c8_4f02_9fd0_21e46b7690de
is encoded by: hsa:4708
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: H7C5B8
type: Species
name: NDUFB2

metaM phaccoa c
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
constant: false
is: CHEBI:57390
initial concentration: 1.0
name: phenylacetyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
is: HMDB06503

metaM gluside hs g
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e0869cca_b9b5_4c30_b46c_9c7f67d5b3c7
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10195
name: ALG3
has only substance units: false
boundary condition: true
type: Species
is: Q92685
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_5a38abb0_e69a_4131_93df_6dd43d7fc554
is encoded by: hsa:8818
constant: false
initial concentration: NaN
has part: Q9BRB3
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
has part: Q14442
is encoded by: hsa:51227
is encoded by: hsa:5277
has part: O94777
type: Species
is encoded by: hsa:5279
has only substance units: false
has part: B3KUV7
is encoded by: hsa:9091
has part: Q92535
is: SBO:0000297
is encoded by: hsa:5283

metaM 6pgc r
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58759
constant: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: HMDB01316
type: Species
initial concentration: 1.0
has only substance units: false
name: 6-phosphonatooxy-D-gluconate

metaR r1662
reactant: MODEL1310110038#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110038#

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_e1432097_871a_402d_bcfe_90fce54de2e9
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6566
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: SLC16A1
is: B4DKS0
boundary condition: true

metaR RE3301C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
is described by: ECO:0000000
name: RE3301
modifier: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
type: Reaction

metaR r0974
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
fast: false
name: Active transport
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reversible: true

metaR G12MT1 U
is: SBO:0000176
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110038#

metaM ksi pre29 g
constant: false
has only substance units: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 29
boundary condition: false
initial concentration: 1.0

metaM pro D e
boundary condition: false
is: CHEBI:16313
is: HMDB03411
has only substance units: false
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

metaR ATP2ter
fast: false
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true

metaR DMNONCRNCPT2
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110038#
name: DMNONCRNCPT2

http://identifiers.org/biomodels.db/MODEL1310110038#_08cd5460_f9cb_4841_80bd_a215dcb48738
type: Species
name: _NM_001929_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:NM 001929
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_0ee2f7a2_6896_4d6e_8969_cbc0415a19cb
type: Species
is: SBO:0000252
has only substance units: false
name: GALK2
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:2585
initial amount: NaN

metaM hxcoa x
is: HMDB00705
name: Hexanoyl-CoA (n-C6:0CoA)
constant: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1384d455_0484_4bd5_b467_cd55be3b08c0
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
name: AK4
initial amount: NaN
is encoded by: hsa:205

metaR LALDO
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
reversible: true
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD

metaR NACHEX3ly
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#

metaM 3dphb m
constant: false
is: SBO:0000247
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
name: 3-Decaprenyl-4-hydroxybenzoate
initial amount: NaN
is: HMDB06251
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_70ae7b0d_6846_44f0_ac91_c62134655087
has only substance units: false
name: PRPS1L1
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:221823

metaR r0973
name: Facilitated diffusion
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_0aa3c491_819a_45c9_9b46_59dc59575c87
is: Q86VV3
name: ENTPD1
is encoded by: hsa:953
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM rib D c
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16988
boundary condition: false
name: D-ribose
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: HMDB00283
constant: false
is: SBO:0000247

metaM CE2417 m
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123
constant: false
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: CHEBI:28387

metaR r0587
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#

metaM hxan c
constant: false
name: Hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C00262
is: CHEBI:17368
is: HMDB00157
boundary condition: false

metaR RE1521M
is described by: ECO:0000000
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
name: RE1521
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction

metaR MALT
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (2595.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:12370436,PMID:7018580 NOTES:IF
fast: false
name: alpha-glucosidase
modifier: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.20

metaR EX 3hdececrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_9fff31e6_0d06_4e21_a9a4_2276d8228c4e
boundary condition: true
is: B3KUK6
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: NT5C1B
constant: false
is encoded by: hsa:93034

metaR r1660
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR NADPHtxu
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
is described by: ECO:0000000
is: SBO:0000185
name: NADPH transporter, peroxisome
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_fd0858df_d17b_4232_8e79_e6c4f757fa78
initial amount: NaN
is encoded by: hsa:220
is: SBO:0000252
constant: false
boundary condition: true
name: ALDH1A3
has only substance units: false
is: P47895
type: Species
initial concentration: NaN

metaR RE0944E
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
name: RE0944
reactant: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaM btcoa x
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
is: C00136
type: Species
initial concentration: 1.0
constant: false
is: HMDB01088
name: Butanoyl-CoA
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b0f33384_15d8_4152_bcbf_7e412087671e
name: _AU149534_1_c
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AU149534
initial amount: NaN

metaM C05957 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:27485
constant: false
has only substance units: false
is: HMDB02710
initial concentration: 1.0
is: SBO:0000247

metaR ICDHyrm
modifier: MODEL1310110038#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_32ea6617_9d1b_49bb_b2d6_1953e203351b
type: Species
initial amount: NaN
is encoded by: hsa:8525
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: DGKZ
constant: false
is: B7Z6M3

metaM thmmp m
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: thiamine(1+) monophosphate(2-)
is: HMDB02666
is: CHEBI:37575
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
is: SBO:0000247
has only substance units: false

metaR RE0688E
is described by: ECO:0000000
modifier: MODEL1310110038#
name: RE0688
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR NACHEXA21ly
is: SBO:0000176
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: false

metaR r1661
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_edaddc4c_11cc_4b68_a05b_dd6c897d50c2
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: COX7A2L
is encoded by: hsa:9167
constant: false
initial concentration: NaN
boundary condition: true
is: Q6FGA0

metaM rib D e
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16988
boundary condition: false
name: D-ribose
initial concentration: 1.0
is: HMDB00283
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247

metaR r0830
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185

metaR DM atp c
reversible: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110038#
is described by: ECO:0000134
name: DM_atp(c)

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
reversible: true
name: valine transaminase, mitochondiral

metaR 34HPLFM
type: Reaction
reversible: false
product: MODEL1310110038#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: 3-(4-hydroxyphenyl-)lactate formation
is described by: ECO:0000000

metaM 3htdcoa m
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
is: HMDB02288
type: Species

metaR ADNCYC
is: SBO:0000176
is described by: ECO:0000269
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.6.1.1
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
product: MODEL1310110038#
name: adenylate cyclase
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false

metaR SUBERICACT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_147839ed_a31d_43aa_a3eb_40577c69b51a
initial concentration: NaN
name: PIGO
is: Q8TEQ8
has only substance units: false
is encoded by: hsa:84720
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_a863c6b5_7c6d_4c65_b797_88a427ea24fc
name: PKM2
has only substance units: false
is encoded by: hsa:5315
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: B4DNK4
initial amount: NaN

metaR RE1845X
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
product: MODEL1310110038#

metaR r0584
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
reversible: true
is: SBO:0000176
modifier: MODEL1310110038#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r1666
reversible: true
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#

metaR NICRNS
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
name: NICRNS
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110038#

metaR FADH2ETC
type: Reaction
kinetic law: MODEL1310110038#
name: Complex II reaction for respiratory chain
fast: false
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110038#
product: MODEL1310110038#

metaM lneldccrn m
boundary condition: false
name: Linoelaidyl carnitine
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06461

metaR H6ET3er
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
reactant: MODEL1310110038#
is: SBO:0000176
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/2.7.8.1

metaM r5p c
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial concentration: 1.0
is: HMDB00618
initial amount: NaN
name: alpha-D-Ribose 5-phosphate
is: C00117
constant: false
is: CHEBI:18189
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaM dgchol e
type: Species
has only substance units: false
is: HMDB00637
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: glycochenodeoxycholate

metaM xylu D c
boundary condition: false
is: HMDB01644
is: CHEBI:17140
type: Species
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
has only substance units: false
name: D-xylulose
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC142C142OHm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaR r0836
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110038#
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR FAOXC184C164m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM leuktrC4 e
initial amount: NaN
is: SBO:0000247
name: leukotriene C4(2-)
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
type: Species
is: HMDB01198

http://identifiers.org/biomodels.db/MODEL1310110038#_6f6413cc_b14c_4b56_adc5_2d1b8b95ec0a
type: Species
is: SBO:0000252
initial amount: NaN
name: ND5
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: P03915
is encoded by: hsa:4540

http://identifiers.org/biomodels.db/MODEL1310110038#_10563738_a533_48e9_b29e_b81f62eb2e1f
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: F5H066
initial amount: NaN
boundary condition: true
is encoded by: hsa:6560
initial concentration: NaN
name: SLC12A4

metaR TCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
type: Reaction
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
name: bile acid intracellular transport
reactant: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_51e232d5_fe78_4000_8df6_d26c85cd5b17
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: PCBD1
is encoded by: hsa:5092
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_b8b6d58c_abbb_4544_ae4d_57151dad3e02
is: SBO:0000252
is encoded by: hsa:128
constant: false
initial amount: NaN
is: Q6IRT1
type: Species
name: ADH5
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 2octdectecoa m
name: 2,6,9,12-octadecatetraenoylcoa
constant: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaR r1667
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaR NCNt
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-NH4+ exchange
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110038#
product: MODEL1310110038#

metaR S6T15g
modifier: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.8.2.21
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaR r0835
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110038#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110038#
is: SBO:0000185

metaR RE1532M
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
modifier: MODEL1310110038#
name: RE1532
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM adpac c
notes: FORMULA: C6H8O4 CHARGE: -2
has only substance units: false
constant: false
name: adipic acid
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00448
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_11329f7a_d10c_406c_bd51_8ffb3d6de0b4
constant: false
name: SULT1A1
type: Species
initial concentration: NaN
is: P50225
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6817
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6d1e04d1_e9c5_4076_a07a_84b9c8030ab9
is encoded by: hsa:3295
initial amount: NaN
initial concentration: NaN
type: Species
is: E9PB82
name: HSD17B4
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR FAOXC164GC163m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR r1664
fast: false
is: SBO:0000185
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110038#

metaR C226CRNt
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
name: C226 transport into the mitochondria
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_485170c9_2a01_4120_9ad7_2411e65ad601
is encoded by: hsa:2348
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: FOLR1

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR r0834
reversible: true
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185

metaM g1p c
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
has only substance units: false
is: SBO:0000247
name: D-Glucose 1-phosphate
constant: false
is: C00103
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01586

metaM dgchol c
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00637
is: CHEBI:36252
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_3d90ac6d_1300_47e5_af6a_e16a48b6205b
initial amount: NaN
boundary condition: true
is: Q92835
initial concentration: NaN
type: Species
name: INPP5D
is encoded by: hsa:3635
is: SBO:0000252
has only substance units: false
constant: false

metaM hxan e
type: Species
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
is: CHEBI:17368
is: HMDB00157
name: hypoxanthine
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR PRPPS
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
name: phosphoribosylpyrophosphate synthetase
is: SBO:0000176
modifier: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
type: Reaction

metaR MI4PP
name: myo-inositol 4-phosphatase
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reactant: MODEL1310110038#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
is described by: ECO:0000269

metaR UMPK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: UMP kinase (dGTP)
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_3bd6630d_f5ac_4e3b_a9a1_801d55401dec
initial amount: NaN
is: Q9BT22
initial concentration: NaN
name: ALG1
is: SBO:0000252
is encoded by: hsa:56052
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR r1665
type: Reaction
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_8f4a9e4a_30ec_4e6d_ac1a_93b1c278705e
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: _AA629629_1_m
is: SBO:0000252
is encoded by: hsa:AA629629
initial amount: NaN

metaR TAGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110038#
type: Reaction
name: triacylglycerol transport
reactant: MODEL1310110038#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_cb232605_8013_4404_a7f4_28300da6c81c
is: O95169
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4714
constant: false
name: NDUFB8
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

metaM CE4872 m
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15748
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00127
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

http://identifiers.org/biomodels.db/MODEL1310110038#_69f192f1_e33b_4ce5_8f8a_4deaa1dfed62
has only substance units: false
initial amount: NaN
is encoded by: hsa:79369
initial concentration: NaN
is: Q9C0J1
name: B3GNT4
is: SBO:0000252
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_00510a84_b7b5_44c6_bff7_deb544a1a5c8
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:586
constant: false
type: Species
initial amount: NaN
is: P54687
name: BCAT1

metaR G14T20g
reactant: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR PI45PLC
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_fc583e67_5254_4620_9ed7_6acb269200bb
is: Q9NRD8
initial concentration: NaN
is encoded by: hsa:50506
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: DUOX2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_e7d5cfc8_8cf9_4fe5_a59b_842626ffddba
initial concentration: NaN
has part: P22392
boundary condition: true
has only substance units: false
has part: P15531
type: Species
constant: false
is encoded by: hsa:4831
initial amount: NaN
name: NME1:NME2
is: SBO:0000297
is encoded by: hsa:4830

metaR FAOXC226C225m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_675ee4c6_d3a7_4d7e_8f8e_866affc9a9eb
name: ATP5A1
is encoded by: hsa:498
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: B4DY56
constant: false
type: Species
has only substance units: false

metaR NDP3ex
is described by: ECO:0000269
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
fast: false
name: nucleoside-diphosphatase (GDP), extracellular
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is version of: http://identifiers.org/ec-code/3.6.1.6

metaM thr L c
constant: false
boundary condition: false
is: CHEBI:16857
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: L-threonine
has only substance units: false
is: HMDB00167
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

metaM dcmp n
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: dCMP(2-)
is: CHEBI:57566
initial amount: NaN
initial concentration: 1.0
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR r0580
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_0cb7d166_475d_43ee_b8eb_c2a9a75bc774
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ALPPL2
is: SBO:0000252
is: P10696
constant: false
initial amount: NaN
is encoded by: hsa:251

metaR ALCD21 D
kinetic law: MODEL1310110038#
fast: false
name: alcohol dehydrogenase (D-1,2-propanediol)
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110038#_51969f30_0a73_485b_b4b5_ae62b6e5fe15
has only substance units: false
is: SBO:0000252
name: FOLR1
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:2348
initial amount: NaN
boundary condition: true

metaR GGH 7DHFe
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110038#
type: Reaction
reversible: false
fast: false

metaR 34DHXMANDACOX
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
product: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110038#_6f0751ae_6d2d_4f42_8532_cd3a6f3bb41d
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:218
is: SBO:0000252
initial amount: NaN
name: ALDH3A1
is: P30838
type: Species

metaR HSD11B1r
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.146
product: MODEL1310110038#
name: 11-beta-hydroxysteroid dehydrogenase type 1
is described by: ECO:0000269
reactant: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_02d5136c_105f_4bde_afed_183192e0a529
initial amount: NaN
initial concentration: NaN
name: PPAP2A
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:8611
boundary condition: true
is: G3XA95
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_9eb0c020_0a7c_4aa0_b916_c24a118ab62d
initial amount: NaN
type: Species
is: P06576
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:506
is: SBO:0000252
name: ATP5B
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_eaffbc97_6b9b_4e4f_8730_45743fc56d69
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:6476
name: SI
type: Species
is: P14410
has only substance units: false

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_ea80bc6b_4648_4924_8a2a_60fcf07e7712
is: SBO:0000252
is encoded by: hsa:4722
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: O75489
name: NDUFS3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_a15127c0_98b8_4314_8326_9a3939a38eb7
initial amount: NaN
is: P00533
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1956
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: EGFR

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
fast: false
type: Reaction
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaM orn c
is: C01602
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:0
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
is: HMDB00214
name: Ornithine
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_368e91db_062e_41bb_9e22_4d66f36782d4
boundary condition: true
is encoded by: hsa:5372
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
name: PMM1
is: SBO:0000252
is: A8K003
constant: false

metaR r0437
reactant: MODEL1310110038#
reversible: true
type: Reaction
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false
is described by: ECO:0000000
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR r0839
reversible: true
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_aa95df73_9af0_445d_bee1_ac6a34eb6842
name: _AA081045_1_c
is encoded by: hsa:AA081045
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaR FATP8t
is described by: ECO:0000269
fast: false
modifier: MODEL1310110038#
reversible: true
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
name: fatty acid electroneutral transport
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM gluside hs r
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
is: CHEBI:18368
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: D-glucosyl-N-acylsphingosine
is: SBO:0000247
has only substance units: false

metaM gluala e
boundary condition: false
is: HMDB06248
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6503
name: 5-L-Glutamyl-L-alanine
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: C03740
has only substance units: false
constant: false

metaM thr L e
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00167
name: L-threonine
type: Species
constant: false
has only substance units: false

metaR r1668
product: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110038#

metaM q10h2 e
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Ubiquinol-10
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740

metaM ksii core4 pre4 g
notes: FORMULA: C61H99N5O43X CHARGE: -1
initial concentration: 1.0
is: CHEBI:58053
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00175
type: Species
is: C00130
constant: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4

http://identifiers.org/biomodels.db/MODEL1310110038#_d9d2aaef_57ef_4aad_8ffa_6ed479feda30
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:5295
has part: E7EX19
type: Species
name: PIK3CD:PIK3R1
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM CE2416 x
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416
type: Species
name: (2R,6S,10S)-pristanate

metaR r0838
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
fast: false
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110038#
name: Free diffusion
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110038#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM 2decdicoa m
name: 2,7-decadienoylcoa
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

metaR r1669
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
fast: false
product: MODEL1310110038#

metaR PAPStg
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
fast: false
modifier: MODEL1310110038#
product: MODEL1310110038#
name: 3'-Phosphoadenylyl sufate Golgi transport
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_c42f2072_a009_4837_9def_96d5bea115f4
boundary condition: true
is encoded by: hsa:64087
is: Q9HCC0
constant: false
name: MCCC2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_11338efe_95f0_4122_b16b_80b7014163c1
is: Q9BUM1
type: Species
boundary condition: true
name: G6PC3
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:92579
is: SBO:0000252
has only substance units: false

metaM ksi pre13 g
boundary condition: false
is: CHEBI:58053
type: Species
initial concentration: 1.0
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
is: C00130
name: keratan sulfate I biosynthesis, precursor 13
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00175

metaR r0410
fast: false
reversible: true
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_da3021b9_452e_46c6_9a2f_4d3b17e68b79
is: SBO:0000252
name: SLC17A1
initial amount: NaN
boundary condition: true
constant: false
is: Q14916
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6568
type: Species

metaR GLNALANaEx
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
modifier: MODEL1310110038#
is described by: ECO:0000269
name: L-alanine/L-glutamine Na-dependent exchange (Gln-L in)

http://identifiers.org/biomodels.db/MODEL1310110038#_09ef5865_e09d_4b20_88d5_16774a9af92f
is: SBO:0000252
type: Species
is encoded by: hsa:6476
is: P14410
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SI

http://identifiers.org/biomodels.db/MODEL1310110038#_70389c53_0c1a_4cf6_86b7_3677fb399789
boundary condition: true
is encoded by: hsa:2589
name: GALNT1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: Q10472

metaM 4abutn e
initial amount: NaN
is: CHEBI:58264
is: HMDB01080
name: 4-ammoniobutanal
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

http://identifiers.org/biomodels.db/MODEL1310110038#_f0985184_89fe_49d5_a051_719c38b36c1a
is encoded by: hsa:5296
is: SBO:0000252
type: Species
constant: false
name: PIK3R2
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: O00459
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_39177578_5755_4534_8643_ceb9e6b81d5a
boundary condition: true
name: NDUFA4L2
initial concentration: NaN
is encoded by: hsa:56901
is: SBO:0000252
constant: false
is: Q9NRX3
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_488324ca_bd89_43ca_bce1_ec366ba8ffb4
name: SUCLG1
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8802
boundary condition: true
is: P53597
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_c442ca19_7a22_4d0e_a34e_5e16aaebc8cd
is encoded by: hsa:9377
boundary condition: true
is: P20674
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: COX5A
has only substance units: false
constant: false

metaM btcoa m
is: C00136
boundary condition: false
name: Butanoyl-CoA
is: HMDB01088
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: CHEBI:57371

metaR C10DCc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_87ef90a1_d06c_409f_9180_2d03e3088f89
has part: P57054
is encoded by: hsa:5279
has part: B2RAU6
is encoded by: hsa:9091
is encoded by: hsa:5277
initial amount: NaN
initial concentration: NaN
constant: false
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:51227

http://identifiers.org/biomodels.db/MODEL1310110038#_8adcfe37_d0d1_474f_8c7b_daa0b9a8ad3e
type: Species
is: P51687
has only substance units: false
name: SUOX
is encoded by: hsa:6821
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1649cb4d_9472_4b62_8be9_fb06c6a4c8f7
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI539321
constant: false
name: _AI539321_1_c

http://identifiers.org/biomodels.db/MODEL1310110038#_7ec21029_acc2_4f50_a573_0b2692807ac0
is encoded by: hsa:8836
initial amount: NaN
has only substance units: false
type: Species
is: Q92820
is: SBO:0000252
boundary condition: true
constant: false
name: GGH
initial concentration: NaN

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaR PYNP2r
name: pyrimidine-nucleoside phosphorylase (uracil)
reactant: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false

metaM glutcoa m
initial concentration: 1.0
is: CHEBI:57378
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01339
type: Species
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527

http://identifiers.org/biomodels.db/MODEL1310110038#_57db9b50_ef45_441e_9620_d13fe3b071cc
has only substance units: false
is encoded by: hsa:6526
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: SLC5A3
boundary condition: true
is: P53794
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_cd1e87ae_6252_48e0_adf4_dbc50c06a77a
has part: A8K7W0
is encoded by: hsa:55350
constant: false
name: VNN3:VNN2:VNN1
type: Species
has part: O95497
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8875
is encoded by: hsa:8876
is: SBO:0000297

metaR CYSTS
name: cystathionine beta-synthase
is version of: http://identifiers.org/ec-code/4.2.1.22
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_4159491a_8f0e_4d15_9f80_245eae21cd55
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:84812
initial amount: NaN
name: PLCD4
constant: false
is: Q9BRC7
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_c4417cc2_d1f0_4f90_b20a_7e327eab79e6
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AA614647_1_c
type: Species
is encoded by: hsa:AA614647
boundary condition: true
initial amount: NaN
constant: false

metaR r0295
is: SBO:0000176
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaM 3htdcoa c
name: (S)-3-Hydroxytetradecanoyl-CoA
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02014
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
boundary condition: false

metaM 2mop m
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

http://identifiers.org/biomodels.db/MODEL1310110038#_83375cbe_38b5_4f07_9fde_cf2141b3866e
initial amount: NaN
is: Q6PCB7
is encoded by: hsa:376497
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: SLC27A1
initial concentration: NaN
type: Species

metaM estradiol r
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
constant: false
name: estradiol
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00151
boundary condition: false
is: CHEBI:16469
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_4c7a3384_d2ad_4615_9bf8_5d0c17195331
initial amount: NaN
type: Species
boundary condition: true
is: D9HTE9
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6576
name: SLC25A1
has only substance units: false

metaR RE2426C
is described by: ECO:0000000
type: Reaction
name: RE2426
kinetic law: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
reactant: MODEL1310110038#
reversible: true
fast: false

metaR FAOXC15ATPx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaM CE4872 c
is: HMDB00127
type: Species
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:15748
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c3b1c583_92f5_482f_8390_d22503c101e1
is: SBO:0000252
is: A7E2E5
constant: false
type: Species
is encoded by: hsa:5140
has only substance units: false
initial concentration: NaN
boundary condition: true
name: PDE3B
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_0108e2b5_9ad3_42ed_84fb_151dd08a3d42
is encoded by: hsa:1120
type: Species
name: CHKB
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: Q9Y259
is: SBO:0000252

metaM 4abutn c
is: C00555
is: SBO:0000247
name: 4-Aminobutanal
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58264
is: HMDB01080
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR ACGALK
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
fast: false
name: N-acetylgalactosamine kinase
product: MODEL1310110038#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110038#_d39d8920_c9a5_48ff_97c0_7888f4ee088e
is encoded by: hsa:124637
has only substance units: false
name: CYB5D1
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: Q6P9G0
boundary condition: true

metaR SMPD3g
is version of: http://identifiers.org/ec-code/3.1.4.12
is described by: ECO:0000304
type: Reaction
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
reversible: false
reactant: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110038#

metaR SERGLNexR
type: Reaction
reversible: true
product: MODEL1310110038#
is described by: ECO:0000304
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
name: L-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaR SERALANaEx
is described by: ECO:0000269
reversible: false
type: Reaction
name: L-alanine/L-serine Na-dependent exchange (Ser-L in)
fast: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#

metaM ficytC m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15991
name: Ferricytochrome c

metaM thbpt4acam n
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: HMDB02281
is: CHEBI:15374

http://identifiers.org/biomodels.db/MODEL1310110038#_3f0b5102_1dab_4b22_97f9_19506586ee78
constant: false
initial amount: NaN
name: AK3
is encoded by: hsa:50808
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: E7ET30
boundary condition: true

metaR MMSAD1m
reversible: false
product: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is version of: http://identifiers.org/ec-code/1.2.1.27
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: methylmalonate-semialdehyde dehydrogenase

metaM vacccrn c
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
has only substance units: false
is: HMDB06351
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: Vaccenyl carnitine
initial concentration: 1.0
type: Species

metaM dcholcoa r
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292

metaR ATPS4m
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.6.1.14
reactant: MODEL1310110038#
name: ATP synthase (four protons for one ATP)
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.4.6
is: SBO:0000185
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.6.3.14
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_89d9dc76_50a0_4d42_97b3_6f234a6df8e0
is encoded by: hsa:2878
is: P22352
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: GPX3
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR H2MTer L
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
name: H2 mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR UDPDOLPT U
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.117
kinetic law: MODEL1310110038#

metaR UMPK2
modifier: MODEL1310110038#
name: UMP kinase (CTP)
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction

metaR UGLCNACtg
name: UDP-GlcNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110038#
fast: false
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_996d8122_0f7a_4548_b29c_806b7435fdef
is: SBO:0000252
initial amount: NaN
name: AQP9
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: O43315
constant: false
is encoded by: hsa:366

metaM thmmp c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB02666
type: Species
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: C01081
is: CHEBI:37575
name: Thiamin monophosphate
boundary condition: false
constant: false
has only substance units: false

metaM cdp m
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
initial amount: NaN
is: CHEBI:58069
is: HMDB01546
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_775eb558_4fe6_47dd_b2de_93d44f581574
has only substance units: false
is: O43677
constant: false
is: SBO:0000252
name: NDUFC1
is encoded by: hsa:4717
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

metaR HAtly
name: hyaluronan transport, extracellular to lysosome
is: SBO:0000185
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_668e582c_fd95_4039_9dd2_dbb97e0bff1e
constant: false
is: SBO:0000252
is encoded by: hsa:3163
name: HMOX2
is: P30519
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR FATP9t
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
modifier: MODEL1310110038#
type: Reaction
name: fatty acid electroneutral transport
is: SBO:0000185

metaM cs e l
initial amount: NaN
is: HMDB02183
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
boundary condition: false
is: CHEBI:36005
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
has only substance units: false

metaR UMPK3
fast: false
name: UMP kinase (UTP)
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110038#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_6fd8c9f0_7769_4411_8716_cd02b027047b
boundary condition: true
is encoded by: hsa:480
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: ATP1A4:ATP1B1
has part: Q13733
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110038#_98c7592b_8934_41c7_b8ff_ad5e210b2f8e
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:112
name: ADCY6
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_23cd9703_1a74_4c44_bb8c_97925b059b29
is encoded by: hsa:8525
initial amount: NaN
is: G3V0F6
type: Species
initial concentration: NaN
constant: false
name: DGKZ
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM cdp n
has only substance units: false
is: SBO:0000247
name: CDP(3-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58069
type: Species
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR NDPK5n
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
fast: false
product: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#

metaR 34HPPte
name: Transport of 3-(4-hydroxyphenyl)pyruvate
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110038#

metaR UMPK4
reactant: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
fast: false
reversible: true
name: UMP kinase (GTP)
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR C18OHc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d769a62c_94d3_4601_beb1_f44a137bb2eb
is encoded by: hsa:9187
type: Species
constant: false
boundary condition: true
name: SLC24A1
is: B4DUG1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX CE1939 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine monoaldehyde 1 exchange
type: Reaction

metaR UDPGD
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
modifier: MODEL1310110038#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000304
name: UDPglucose 6-dehydrogenase
reactant: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.22

metaR ENGASE2ly
kinetic law: MODEL1310110038#
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110038#_3a0a0b0b_9fe4_4ae8_9aba_a17a6c580626
is: B3KWF4
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:63917
has only substance units: false
name: GALNT11
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_283adba3_4ca5_48a1_8e26_8d0c6b5aca6b
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: PDE7A
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5150
type: Species
is: Q13946

metaR CYTDt
fast: false
modifier: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: cytidine facilated transport in cytosol
reversible: true
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269

metaR ADPtx
name: ADP transporter, peroxisomal
reactant: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#

metaR LTA4H
product: MODEL1310110038#
reversible: false
name: Leukotriene A-4 hydrolase
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.3.2.6
is described by: ECO:0000134
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ

metaR C50CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
product: MODEL1310110038#
name: inositol-1,4,5-trisphosphate 5-phosphatase
fast: false
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000176

metaR PI345P3P
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is: SBO:0000176
reversible: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
product: MODEL1310110038#

metaR UMPK5
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
name: UMP kinase (dATP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110038#

metaR GLCter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110038#
name: glucose transport, endoplasmic reticulum
is: SBO:0000185

metaM sbt D c
initial amount: NaN
name: D-glucitol
is: CHEBI:17924
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00247

metaM 3sala c
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
constant: false
type: Species
is: SBO:0000247
name: 3-Sulfino-L-alanine
initial amount: NaN
is: C00606
initial concentration: 1.0
is: CHEBI:61085
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_56f8248f_480a_4924_b0f0_4807228b719c
type: Species
initial amount: NaN
is encoded by: hsa:218
has only substance units: false
name: ALDH3A1
is: SBO:0000252
boundary condition: true
is: P30838
constant: false
initial concentration: NaN

metaM dolp L c
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: dolichyl phosphate(2-)
type: Species
constant: false
is: CHEBI:57683
initial concentration: 1.0

metaR DOCO13EFATP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

metaR FAOXC184C164x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR RE3346C
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
name: RE3346
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110038#

metaR UMPK6
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP)
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110038#
is described by: ECO:0000269
fast: false
product: MODEL1310110038#
modifier: MODEL1310110038#

metaR BTNtn
kinetic law: MODEL1310110038#
name: Biotin transport, nuclear
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
is: SBO:0000185

metaM cala c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:11892
is: HMDB00026
has only substance units: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
name: N-carbamoyl-beta-alaninate
initial amount: NaN

metaR ALCD21 L
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000304
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.1
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110038#
name: alcohol dehydrogenase (L-1,2-propanediol)
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
type: Reaction

metaM n2m2masn g
initial amount: NaN
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
notes: FORMULA: C50H83N4O35X CHARGE: 0
has only substance units: false
is: C11530
is: SBO:0000247

metaR GARFT
modifier: MODEL1310110038#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
fast: false
reactant: MODEL1310110038#

metaM sbt D e
initial amount: NaN
is: HMDB00247
boundary condition: false
constant: false
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e571d9d5_1a3e_48b1_b38f_723e563e0fa9
initial amount: NaN
is: Q8N1G6
name: GPAM
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57678
is: SBO:0000252
type: Species

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c714868e_8429_446b_97b1_e9a5cdea1bda
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: BDH1
is encoded by: hsa:622
type: Species
has only substance units: false
initial concentration: NaN

metaR VLCSp
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
product: MODEL1310110038#
fast: false
type: Reaction
kinetic law: MODEL1310110038#
name: Very-long-chain-fatty-acid-CoA ligase
reversible: false

metaR GALASE5ly
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
reactant: MODEL1310110038#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR r1935
reversible: false
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#

metaR HACD9m
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000134
product: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_a8a760b3_a534_4194_91d8_17c684b302ea
has only substance units: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000297
has part: P48201
is encoded by: hsa:518
constant: false

metaR RE0828E
kinetic law: MODEL1310110038#
name: RE0828
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
fast: false

metaM 4abutn m
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58264
is: SBO:0000247
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
name: 4-ammoniobutanal
type: Species

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM lac D e
initial concentration: 1.0
name: (R)-lactate
has only substance units: false
initial amount: NaN
is: CHEBI:16004
type: Species
is: HMDB01311
boundary condition: false
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: SBO:0000247

metaR CYTDn
is: SBO:0000176
reversible: false
is described by: ECO:0000254
modifier: MODEL1310110038#
name: cytidine deaminase, nuclear
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110038#
product: MODEL1310110038#

metaM vacccrn m
has only substance units: false
name: Vaccenyl carnitine
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06351
constant: false
initial concentration: 1.0

metaR r0149
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: MODEL1310110038#
modifier: MODEL1310110038#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
is: SBO:0000176

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_bf8cb738_f41f_47dd_a5cb_9a75d47ff051
type: Species
initial amount: NaN
constant: false
is: P49441
name: INPP1
is encoded by: hsa:3628
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_10c0d25c_0da0_46dd_a519_caccfc0e2051
is encoded by: hsa:9123
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: SLC16A3
initial concentration: NaN
is: O15427
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_a0422a52_2b0f_4b5d_a646_e863ef93e61f
name: PIK3CD:PIK3R3
is: SBO:0000297
has part: A7E2E0
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5293
has only substance units: false
is encoded by: hsa:8503
has part: Q92569
initial concentration: NaN

metaR PALFATPtc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b720d52e_d186_4b9b_8ea5_e34338363620
is: SBO:0000252
is: B4DYG5
constant: false
initial concentration: NaN
name: PI4KA
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:5297

http://identifiers.org/biomodels.db/MODEL1310110038#_c3b2a29b_db3b_4f63_8169_7b64cca282a8
constant: false
name: MTHFR
boundary condition: true
has only substance units: false
is encoded by: hsa:4524
initial concentration: NaN
initial amount: NaN
type: Species
is: Q59GJ6
is: SBO:0000252

metaR C142ACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_198f56c9_679d_4ee5_82ea_052973b5ed04
is: O95169
initial concentration: NaN
constant: false
initial amount: NaN
name: NDUFB8
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4714
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_8bfe8dd2_f9bb_4c35_8a2a_4ef31f819b6b
has only substance units: false
type: Species
boundary condition: true
name: PAPSS2
is: O95340
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9060

http://identifiers.org/biomodels.db/MODEL1310110038#_89d02cd8_0cde_43b6_8f8d_2af73c375b36
is encoded by: hsa:53354
name: PANK1
initial concentration: NaN
has only substance units: false
is: Q8TE04
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR RE1254C
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
name: RE1254
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000176

metaM dsT antigen g
is: HMDB01440
name: disialyl-T antigen
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: CHEBI:16497
has only substance units: false
type: Species

metaR OMPDC
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.10
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
name: orotidine-5'-phosphate decarboxylase
product: MODEL1310110038#

metaR SPMTDe
product: MODEL1310110038#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: SPMTDe
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110038#
is: SBO:0000185

metaR FAOXC204
fast: false
reactant: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110038#
is described by: ECO:0000269

metaM 5mthf e
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
name: 5-Methyltetrahydrofolate
is: CHEBI:3729
is: HMDB01396
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_0686bf26_d90b_4783_9416_7e5a5d7077ea
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
boundary condition: true
type: Species
is encoded by: hsa:54344
is: SBO:0000297
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
has part: Q9P2X0

metaR SUBERCACT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_51006537_d808_4675_8830_983bdebf3703
name: ACOT8
is: O14734
type: Species
is: SBO:0000252
is encoded by: hsa:10005
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_fe0ad85c_f372_4c53_be62_3181aa1112db
constant: false
is encoded by: hsa:56953
is: Q9NPB1
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NT5M

metaM lac D c
has only substance units: false
name: (R)-lactate
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16004
type: Species
boundary condition: false
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_572ba233_1e66_4d1c_98d4_87377121111a
is: E7EPT3
is encoded by: hsa:501
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: ALDH7A1
has only substance units: false
constant: false

metaM HC02214 e
boundary condition: false
is: CHEBI:28852
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-f1alpha
constant: false
has only substance units: false

metaR PTDCACRNCPT1
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: carnitine fatty-acyl transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
modifier: MODEL1310110038#
is described by: ECO:0000269
fast: false

metaM mi134p c
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
is: CHEBI:58414
is: HMDB01143
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial amount: NaN

metaR BAAT2x
kinetic law: MODEL1310110038#
name: bile acid Coenzyme A: amino acid N-acyltransferase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is described by: ECO:0000269

metaR r2047
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaR FAOXC225C204x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c6097468_e24b_4574_ba72_b8c7d915a1a4
constant: false
is: SBO:0000252
initial amount: NaN
is: Q8WZ48
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1374
name: CPT1A

http://identifiers.org/biomodels.db/MODEL1310110038#_f78e6c13_c0ac_4173_b8fb_ebfadc55dea7
constant: false
type: Species
initial amount: NaN
name: PRDX1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5052
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_72424f94_d134_4f22_8a32_98ffd548fd09
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC27A2
is: SBO:0000252
is encoded by: hsa:11001
is: O14975
type: Species

metaM 4aphdob c
is: HMDB00978
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial concentration: 1.0
is: CHEBI:58147
initial amount: NaN
constant: false
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM glyclt c
is: CHEBI:29805
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
has only substance units: false
is: SBO:0000247
name: glycolate
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_5d26f3b9_0a94_4da8_8fd7_9314896e6e01
initial amount: NaN
is: SBO:0000252
constant: false
name: ITPKA
initial concentration: NaN
is: P23677
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:3706

metaR r2308
reactant: MODEL1310110038#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110038#
reversible: true
is: SBO:0000185

metaR PTDCACRNCPT2
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: pentadecanoate transport into the mitochondria
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_b528ce4a_e6fd_4c0b_89d6_8c0b05d33b80
boundary condition: true
is: Q9NY65
is: SBO:0000252
is encoded by: hsa:1962
name: EHHADH
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaM 2mop c
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: CHEBI:57700
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB01172

metaR C6CRNtcx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaM xol25oh r
has only substance units: false
is: CHEBI:42977
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06247
boundary condition: false
is: SBO:0000247
name: 25-hydroxycholesterol
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146

metaM tetdece1coa c
name: tetradecenoylcoa
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB05066
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
has only substance units: false
type: Species
boundary condition: false

metaR CITtam
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
is described by: ECO:0000269
modifier: MODEL1310110038#
name: citrate transport, mitochondrial
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_dce73662_eb12_415e_b191_02d0c4a63745
is: SBO:0000252
name: ALDH1A2
initial concentration: NaN
is encoded by: hsa:8854
type: Species
boundary condition: true
is: F5H2Y9
has only substance units: false
constant: false
initial amount: NaN

metaR H2O2syn
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
is version of: http://identifiers.org/ec-code/1.6.3.1
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176
name: Hydrogen peroxide synthesis (NADPH dependent)

http://identifiers.org/biomodels.db/MODEL1310110038#_23a07e4f_7503_46ea_9d43_75106a6a1af8
initial amount: NaN
is encoded by: hsa:55568
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: GALNT10

metaM HC02214 c
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: prostaglandin-f1alpha
initial amount: NaN

metaM 5mthf c
initial amount: NaN
is: C00440
is: CHEBI:3729
name: 5-Methyltetrahydrofolate
is: HMDB01396
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR DOPABMO
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
kinetic law: MODEL1310110038#
name: dopamine beta-monooxygenase
is version of: http://identifiers.org/ec-code/1.14.17.1
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction

metaR r2309
is described by: ECO:0000000
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false

metaR MGSA
fast: false
kinetic law: MODEL1310110038#
reversible: false
name: methylglyoxal synthase
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
reactant: MODEL1310110038#
is: SBO:0000176

metaR r0145
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.8.3.1
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
product: MODEL1310110038#
reversible: true
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
type: Reaction

metaM ksii core4 pre2 g
name: keratan sulfate II boisynthesis, precursor 2
boundary condition: false
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
is: C00130
has only substance units: false
constant: false
type: Species
is: HMDB00175
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_792ca15b_a4b5_467e_b77f_8539b9175a60
type: Species
is: Q6NSB3
initial concentration: NaN
name: AMY1A
is encoded by: hsa:276
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaM s7p c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
name: Sedoheptulose 7-phosphate
is: CHEBI:57483
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01068
is: C05382
type: Species

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR GLUTCOAACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_934e3bc5_9697_446c_87e5_7501e34f635c
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3290
has only substance units: false
name: HSD11B1
initial amount: NaN
constant: false
is: SBO:0000252

metaM ksi pre12 g
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 12
boundary condition: false
is: CHEBI:58053
constant: false
has only substance units: false
is: HMDB00175
initial amount: NaN
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: C00130
initial concentration: 1.0

metaR DOPAt4 2 r
fast: false
modifier: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110038#
is: SBO:0000185

metaR RE3005M
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3005
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110038#
type: Reaction

metaR DM dctp m
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dCTP demand
type: Reaction

metaM pydx c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: SBO:0000247
boundary condition: false
is: C00250
constant: false
is: HMDB01545
is: CHEBI:17310
name: Pyridoxal
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_3f9d930d_5f8a_4bc5_889d_6fe8e4a37feb
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4351
constant: false
initial concentration: NaN
has only substance units: false
is: P34949
type: Species
name: MPI
boundary condition: true

metaR NS26T2g
reversible: false
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.3
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
kinetic law: MODEL1310110038#
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR AKGMALtm
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter

http://identifiers.org/biomodels.db/MODEL1310110038#_073acde9_575c_4cd3_a997_86611b4db18e
has only substance units: false
boundary condition: true
is: B7Z3K8
initial concentration: NaN
is encoded by: hsa:51004
initial amount: NaN
type: Species
constant: false
name: COQ6
is: SBO:0000252

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM CE5101 m
initial amount: NaN
is: CHEBI:57795
initial concentration: 1.0
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: SBO:0000247
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
has only substance units: false
boundary condition: false

metaR SEBACIDTD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM glutcoa c
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
is: HMDB01339
constant: false
boundary condition: false
initial amount: NaN
name: glutaryl-CoA(5-)
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_07178ae6_9db4_4bdb_95cc_6ffa3d48b875
type: Species
boundary condition: true
name: ATP5I
initial concentration: NaN
is encoded by: hsa:521
has only substance units: false
is: P56385
is: SBO:0000252
initial amount: NaN
constant: false

metaR C141ACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_237cc0ea_9fee_40d4_b8da_b25cdb8bdec3
name: TXNRD2
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:10587
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_9bb62e84_786d_4576_8f26_c6d1e97a6e5c
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:50814
has only substance units: false
name: NSDHL
is: Q15738

http://identifiers.org/biomodels.db/MODEL1310110038#_b763f000_b970_4711_bc66_96a5756b79c3
has only substance units: false
constant: false
is encoded by: hsa:91734
name: IDI2
initial concentration: NaN
is: SBO:0000252
is: Q9BXS1
initial amount: NaN
boundary condition: true
type: Species

metaM 5adtststerone e
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02961
is: CHEBI:16330
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_273d1cec_a211_4792_8a9c_9b9b15a98b47
is encoded by: hsa:5277
has part: P37287
initial amount: NaN
has only substance units: false
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
is encoded by: hsa:8818
initial concentration: NaN
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110038#_81102f2c_99c2_42e0_b063_7949a0ab6d97
is encoded by: hsa:2876
has only substance units: false
initial amount: NaN
constant: false
name: GPX1
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM 5adtststerone c
has only substance units: false
boundary condition: false
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB02961
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0b4c3d74_511d_460c_8800_2782d92fc406
initial concentration: NaN
type: Species
name: _F23536_1_m
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:F23536

metaR RE2269E
name: RE2269
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/3.4.21.39
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:

metaM core4 g
initial concentration: 1.0
notes: FORMULA: C24H40N3O15X CHARGE: 0
type: Species
is: CHEBI:16478
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Core 4
boundary condition: false
constant: false

metaM dmnoncrn x
initial amount: NaN
is: SBO:0000247
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0
has only substance units: false
constant: false
type: Species
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0
boundary condition: false

metaR LINOFATPtc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaM mal L m
boundary condition: false
constant: false
is: SBO:0000247
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
initial amount: NaN
is: CHEBI:15589
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0142
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110038#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
fast: false
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
reactant: MODEL1310110038#

metaM sph1p e
boundary condition: false
constant: false
initial concentration: 1.0
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
is: HMDB01383
type: Species
is: CHEBI:57939
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_7fef9918_5191_4e34_82de_a5a55ec01b72
is encoded by: hsa:10870
is: SBO:0000252
type: Species
boundary condition: true
name: HCST
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9UBK5
constant: false

metaR P4508B13r
name: sterol 12-alpha-hydroxylase (nadh)
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
kinetic law: MODEL1310110038#
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.13.95
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_60273047_ed17_48f1_9b33_cec448ea533b
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: AK2
initial amount: NaN
is encoded by: hsa:204
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_83d4827c_7946_4c76_b184_c8f233ac557a
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: _U37519_1_c
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:U37519

http://identifiers.org/biomodels.db/MODEL1310110038#_30e55eeb_f71f_4728_81f2_d1b6eac3da8f
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1583
is: G3XAD7
constant: false
initial amount: NaN
is: SBO:0000252
name: CYP11A1

metaR EX prgstrn LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Progesterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_a820d530_c9b7_4574_9b58_e4a08b79fc58
name: ATP5H
initial amount: NaN
type: Species
is: O75947
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:10476

metaM sph1p c
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57939
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
is: HMDB01383

metaR FAOXTC101TC102m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaM decdicoa c
initial concentration: 1.0
name: decadienoylcoa
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01168

metaR CDSm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
type: Reaction
name: phosphatidate cytidylyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ

metaR r0963
reactant: MODEL1310110038#
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
fast: false

metaM 3hmbcoa m
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01356
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)

metaM ps hs c
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
initial concentration: 1.0
name: ps_hs[c]
constant: false

metaM arachdcrn r
is: CHEBI:57368
constant: false
initial concentration: 1.0
is: HMDB06523
name: C20:4 carnitine
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
type: Species
initial amount: NaN

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaR NDP8
type: Reaction
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110038#
name: nucleoside-diphosphatase (dUDP)
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_841cc26a_7e9c_4530_b313_3a22cb40f7ba
name: MECR
initial amount: NaN
type: Species
is: Q9BV79
is encoded by: hsa:51102
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR URIK1
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
name: uridine kinase (ATP:Uridine)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_f8373fd0_e320_4548_9c4b_e8ce53d00bb1
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000297
initial concentration: NaN

metaR GLYCt
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: glycerol transport via channel
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_90765976_b576_4e63_adad_3bbfb0b618e0
name: NDUFC1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4717
has only substance units: false
is: O43677
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaR r0841
name: Free diffusion
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.271

metaR r1670
fast: false
modifier: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_7a19639d_d4b2_4420_80ec_99db80d27a86
initial amount: NaN
type: Species
name: SLC22A5
has only substance units: false
constant: false
is: O76082
is encoded by: hsa:6584
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM 3hexdtricoa x
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: HMDB02288
name: 3,7,10-hexadecatrienoylcoa
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

metaR RE0689E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
product: MODEL1310110038#
name: RE0689
type: Reaction
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
modifier: MODEL1310110038#

metaR GPIDA2er
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110038#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cd23dea5_87c7_413d_b15b_4a626e2ae743
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PCBD1
is: P61457
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5092
type: Species

metaM glcur l
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: D-glucuronate
boundary condition: false
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110038#_495c1660_a941_4752_a7e9_69279dd3d927
boundary condition: true
constant: false
name: SCD
type: Species
is encoded by: hsa:6319
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O00767
initial concentration: NaN

metaM ac c
has only substance units: false
constant: false
name: acetate
is: HMDB00042
type: Species
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: CHEBI:30089
initial concentration: 1.0
is: SBO:0000247

metaR FAOXTC102C101m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM ksii core4 pre3 g
is: C00130
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 3
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:58053
has only substance units: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: HMDB00175

metaR r0840
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
reversible: true
name: Free diffusion
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.13.70

metaM pheme e
is: CHEBI:17627
name: Protoheme
is: HMDB03178
is: C00032
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaM sphings c
initial concentration: 1.0
boundary condition: false
is: HMDB00252
name: sphingosine(1+)
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: SBO:0000247
is: CHEBI:57756
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_de35648c_2276_40f1_aba1_81d0cffc0073
initial amount: NaN
has only substance units: false
is encoded by: hsa:5409
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P11086
constant: false
name: PNMT

metaR r0579
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.19
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#

metaR H2Otly
product: MODEL1310110038#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O transport, lysosomal
reactant: MODEL1310110038#

metaR r1671
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110038#

metaR BTNPLm
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false

metaM ps hs e
boundary condition: false
has only substance units: false
is: CHEBI:18303
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM crm hs g
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: CHEBI:52639
constant: false
name: N-acylsphingosine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_f44f672f_192e_431d_a503_a866192b16d6
is: P07741
boundary condition: true
has only substance units: false
is: SBO:0000252
name: APRT
type: Species
is encoded by: hsa:353
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_162e7603_928c_43fb_bcab_60f65fae38cd
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:137964
type: Species
constant: false
name: AGPAT6
is: Q86UL3
boundary condition: true
has only substance units: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_25033296_26d0_4c5a_b468_ee6027a525c6
constant: false
is: Q14542
name: SLC29A2
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3177
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_ec59c92a_6708_4f8f_949d_3ea6a1c2b90d
constant: false
is encoded by: hsa:9197
is: O00400
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC33A1
has only substance units: false

metaR r0960
is: SBO:0000185
reactant: MODEL1310110038#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000

metaR r0578
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000

metaM prostge1 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
is: CHEBI:57397
constant: false
is: HMDB01442
name: prostaglandin E1(1-)
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaM arachdcrn m
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01322
has only substance units: false
is: CHEBI:57387

metaR M1316Mg
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.114
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

metaM crm hs e
type: Species
is: CHEBI:52639
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110038#_0e76e2db_89f0_4965_96c8_50ad57ffb9ae
boundary condition: true
has only substance units: false
name: CDS2
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:8760
is: O95674
initial amount: NaN
constant: false

metaR GALASE18ly
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110038#
reversible: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110038#
fast: false

metaM dolp L r
has only substance units: false
name: dolichyl phosphate(2-)
is: CHEBI:57683
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
is: SBO:0000247

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR NAt3 1
kinetic law: MODEL1310110038#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: sodium proton antiporter (H:NA is 1:1)
type: Reaction
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is: SBO:0000185
product: MODEL1310110038#
reversible: true

metaM pheme c
name: Protoheme
is: HMDB03178
has only substance units: false
is: C00032
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:17627

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR RE3272N
kinetic law: MODEL1310110038#
type: Reaction
name: RE3272
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reactant: MODEL1310110038#
is: SBO:0000176
reversible: true
product: MODEL1310110038#
is described by: ECO:0000000
fast: false

metaR r0842
type: Reaction
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
product: MODEL1310110038#
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

metaR IDOURtly
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
product: MODEL1310110038#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
name: iduronate transport into lysososme
modifier: MODEL1310110038#

metaR XYLt
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110038#
name: D-xylose reversible transport
reversible: true
modifier: MODEL1310110038#
is described by: ECO:0000269

metaR FAOXC101C8m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM ac e
is: HMDB00042
initial concentration: 1.0
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
name: acetate
constant: false
is: SBO:0000247
is: CHEBI:30089
boundary condition: false
type: Species
has only substance units: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_04f1d3ea_b600_4305_a478_d9eee76c0f54
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _728226_1_e
is encoded by: hsa:728226

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_deda0c62_e00e_4e83_86d3_c32a5ca6cb5c
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:54677
boundary condition: true
constant: false
name: CROT
is: E7EQF2

metaR PSFLIPm
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
type: Reaction
reversible: false
is: SBO:0000185
name: phosphatidylserine flippase
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.6.3.1
is described by: ECO:0000269
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

metaR r0962
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
name: Facilitated diffusion
fast: false
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_54078ab3_9eb2_4e20_bb57_f0b9e98004d6
is: SBO:0000252
is: Q06055
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: ATP5G2
boundary condition: true
is encoded by: hsa:517
initial amount: NaN

metaM prostge1 c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57397
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: HMDB01442
name: prostaglandin E1(1-)

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN
is: CHEBI:30245
is: HMDB00673
has only substance units: false
constant: false
type: Species
boundary condition: false
name: linoleate
is: SBO:0000247
initial concentration: 1.0

metaR GALtly
fast: false
is: SBO:0000185
reactant: MODEL1310110038#
name: galactose efflux from lysosome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110038#
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#

metaM crm hs c
constant: false
type: Species
is: CHEBI:52639
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: N-acylsphingosine

metaR S6T16g
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR TCHOLAte
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
is: SBO:0000185

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM hexdectecoa x
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b9b1ff64_04cf_4b91_a06f_d234b6ed6aad
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4846
is: A0S0A7
is: SBO:0000252
has only substance units: false
name: NOS3

metaR r0845
kinetic law: MODEL1310110038#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
product: MODEL1310110038#
reversible: false

metaR r0575
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
reversible: true
product: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_fae0b41c_27eb_447b_aca9_3046b5a7232c
boundary condition: true
name: RPIA
is encoded by: hsa:22934
constant: false
type: Species
has only substance units: false
is: P49247
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR B3GNT39g
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110038#
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR C14STRr
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is: SBO:0000176
name: C-14 sterol reductase
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000134
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70

metaR BTND1n
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.1.12
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
fast: false
name: biotinidase (biotin), nuclear
reversible: false
is: SBO:0000176
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_9e78e719_4dca_4b2a_ace8_a8954275a6ea
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:3418
initial amount: NaN
name: IDH2
type: Species
is: P48735
has only substance units: false

metaR PI4P3K
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate 3-kinase
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaR ACNAM9PL
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.5.1.56
reversible: false
type: Reaction
is described by: ECO:0000269
fast: false
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
product: MODEL1310110038#

metaM hyptaur c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Hypotaurine
is: SBO:0000247
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
constant: false
type: Species
is: CHEBI:16668
has only substance units: false

metaR EX gly LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Glycine
type: Reaction

metaR PI4PLCn
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110038#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110038#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
modifier: MODEL1310110038#
is: SBO:0000176

metaR METtec
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
type: Reaction
modifier: MODEL1310110038#
name: L-methionine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
is described by: ECO:0000269
fast: false

metaM odecoa c
boundary condition: false
has only substance units: false
is: HMDB01322
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: CHEBI:3793

metaM crm hs r
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
is: CHEBI:52639
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: N-acylsphingosine
initial amount: NaN

metaR RIBt
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is described by: ECO:0000000
name: ribose transport via diffusion
kinetic law: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
fast: false
type: Reaction

metaM 3thexddcoacrn c
constant: false
boundary condition: false
initial concentration: 1.0
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Species
is: HMDB02014
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H41NO5 CHARGE: 0
has only substance units: false

metaR r2497
is described by: ECO:0000000
type: Reaction
product: MODEL1310110038#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: false
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

metaR CORE2GTg
is version of: http://identifiers.org/ec-code/2.4.1.102
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
reversible: false
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaM cdp c
is: CHEBI:58069
constant: false
name: CDP
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
type: Species
is: HMDB01546
initial amount: NaN
is: C00112

metaM Rtotalcoa c
has only substance units: false
type: Species
is: HMDB01448
name: R total Coenzyme A
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16189
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110038#_cbd74bc9_b536_4275_988b_bd98cf519770
name: HMOX1
has only substance units: false
boundary condition: true
is encoded by: hsa:3162
initial concentration: NaN
is: Q6FH11
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaM btcoa c
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
constant: false
has only substance units: false
type: Species
is: C00136
is: HMDB01088
initial amount: NaN
is: CHEBI:57371
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR BPNT
is described by: ECO:0000269
kinetic law: MODEL1310110038#
name: 3',5'-bisphosphate nucleotidase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.7
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:

metaM trdox m
initial amount: NaN
is: CHEBI:18191
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Oxidized thioredoxin
constant: false
type: Species
boundary condition: false

metaM dsmsterol r
is: HMDB02719
type: Species
constant: false
initial amount: NaN
name: desmosterol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: SBO:0000247
has only substance units: false
is: CHEBI:17737
initial concentration: 1.0
boundary condition: false

metaR UGALNACtg
product: MODEL1310110038#
name: UDP-GalNAc Golgi transport via CMP antiport
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
is described by: ECO:0000269
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction

metaM omhpal c
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB06294
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false
name: w-hydroxypalmiticacid
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_4cf2d2cd_6800_463b_81b0_f4b2f38c7aab
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2720
type: Species
name: GLB1
is: P16278
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_e23787ae_bef8_4990_80bb_74bd937bd538
type: Species
is: Q16875
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PFKFB3
has only substance units: false
is encoded by: hsa:5209

http://identifiers.org/biomodels.db/MODEL1310110038#_f9e26ede_e6d2_40e6_ba37_5278d761be44
has only substance units: false
initial concentration: NaN
boundary condition: true
name: RFK
type: Species
constant: false
is: B2RDZ2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55312

metaR PMTCOAtx
name: fatty acid intracellular transport
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#

metaR RE1522M
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
type: Reaction
fast: false
name: RE1522
reactant: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true

metaR S4TASE3ly
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110038#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110038#

metaM 2dodtricoa x
has only substance units: false
type: Species
constant: false
is: C05279
name: 2,6,9-dodecatrienoylcoa
is: HMDB11123
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM coucoa m
boundary condition: false
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
is: C00223
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 4-coumaroyl-CoA(4-)
constant: false
type: Species
is: CHEBI:57355

http://identifiers.org/biomodels.db/MODEL1310110038#_8d8701f9_4155_4fe0_b5b1_02cc827bcbd3
is: O95470
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:8879
constant: false
has only substance units: false
name: SGPL1

metaM glcur r
initial amount: NaN
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
name: D-glucuronate
boundary condition: false
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00127

metaM dcholcoa x
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
boundary condition: false
name: chenodeoxycholoyl coenzyme a
is: HMDB06292
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_202b1da6_d73e_469c_8570_273687944e6a
is encoded by: hsa:6818
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: SULT1A3
constant: false

metaR EX 3octdeccrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaM 3thexddcoacrn e
boundary condition: false
initial concentration: 1.0
is: HMDB02014
is: SBO:0000247
type: Species
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
initial amount: NaN
notes: FORMULA: C23H41NO5 CHARGE: 0
constant: false
has only substance units: false

metaM crn x
is: C00318
initial amount: NaN
is: HMDB00062
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16347
name: L-Carnitine
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_1798bfda_3cd0_4ee6_ad7a_f63d2324b669
is encoded by: hsa:10965
is: SBO:0000252
constant: false
initial concentration: NaN
name: ACOT2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: P49753

metaR RE1533M
reactant: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1533
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#

metaM cdp e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
has only substance units: false
is: HMDB01546
name: CDP(3-)
initial amount: NaN
constant: false
is: CHEBI:58069
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_a2423058_dba5_46a9_a22e_7838a0a04f3d
is: SBO:0000252
is encoded by: hsa:10948
type: Species
initial amount: NaN
constant: false
name: STARD3
boundary condition: true
has only substance units: false
is: B4DUY1
initial concentration: NaN

metaR ALOX52
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
product: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.34
is: SBO:0000176
name: Arachidonate 5-lipoxygenase
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
fast: false

metaM phyt x
is: CHEBI:37257
name: phytanate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00801
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
type: Species
constant: false

metaM cholcoa c
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0
has only substance units: false
name: choloyl-CoA(4-)
initial amount: NaN
is: CHEBI:57373
type: Species
is: HMDB01374
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_660dcf94_2c2c_4fc3_98fe_4cd217a3a97d
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:3417
name: IDH1
type: Species
is: O75874
initial concentration: NaN
is: SBO:0000252

metaM ps hs m
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: ps_hs[m]
has only substance units: false
is: CHEBI:18303
constant: false
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006

metaM hxcoa c
name: Hexanoyl-CoA (n-C6:0CoA)
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
is: HMDB13130
constant: false

metaR D LACt2
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
is described by: ECO:0000269
fast: false
name: D-lactate transport via proton symport
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#
modifier: MODEL1310110038#

metaR RTOTALFATPc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_995913f3_8a5a_4ce4_8b5b_bbc9bb872055
has part: Q8WYR1
is encoded by: hsa:23533
is: SBO:0000297
boundary condition: true
constant: false
name: PIK3R5:PIK3CG
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR FAOXC101C8x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_4f1b5430_1f20_4da2_84a4_b69ec7d93cc7
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:84532
name: ACSS1
is: SBO:0000252
has only substance units: false
constant: false
is: Q9NUB1
initial concentration: NaN

metaR FAOXC16180m
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110038#
name: Beta oxidation fatty acid
reversible: false
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110038#
is described by: ECO:0000269

metaM 3hibutcoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: (S)-3-Hydroxyisobutyryl-CoA
type: Species
is: SBO:0000247
is: HMDB01052
constant: false
is: CHEBI:28259
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR FAOXC6C4x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaR ALAGLNNaEx
is: SBO:0000185
reactant: MODEL1310110038#
name: L-alanine/L-glutamine Na-dependent exchange (Ala-L in)
product: MODEL1310110038#
reversible: false
fast: false
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR ARABR
reversible: false
name: arabinose reductase
product: MODEL1310110038#
fast: false
type: Reaction
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110038#_4769d53c_b8a3_47c9_b047_a10d0dd42efe
is: SBO:0000297
is encoded by: hsa:126
boundary condition: true
name: ADH1A:ADH1C
constant: false
type: Species
initial concentration: NaN
has part: P00326
has only substance units: false
initial amount: NaN

metaR SERASNNaEx
name: L-serine/L-asparagine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
fast: false
is: SBO:0000185
reversible: false

metaM HC01162 c
constant: false
is: CHEBI:58376
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_7db92a7b_36f2_44fa_b10e_72e37c143e5d
constant: false
is encoded by: hsa:123041
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC24A4
is: SBO:0000252
type: Species

metaR r0968
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Postulated transport reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: false

metaR NADPtxu
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
name: NADP transporter, peroxisome
reversible: false
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_28cacdd0_42f6_4bc6_8ccf_1909ea17e12c
constant: false
boundary condition: true
name: _R14373_1_x
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:R14373

metaM thbpt4acam c
constant: false
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
is: HMDB02281
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951

metaR r0425
type: Reaction
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
is described by: ECO:0000000
name: EC:1.1.1.42
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110038#

metaM tetde5coa x
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
name: 5-tetradecenoylcoa
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB13109

http://identifiers.org/biomodels.db/MODEL1310110038#_dd42722e_3bd8_41db_a8c2_f17664b092e9
is: B4DGD7
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3423
constant: false
is: SBO:0000252
name: IDS
has only substance units: false
boundary condition: true
type: Species

metaR FAOXC225C204m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR r0570
reversible: true
modifier: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.3.2
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_95dd83f1_c9bd_4208_98f3_ad5c239846db
name: SLC6A2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q96KH8
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6530

metaR METLEUex
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
name: Methionine/Leucine exchange (Met in)
modifier: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#

metaM mi14p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial amount: NaN
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
has only substance units: false
is: HMDB00968
is: CHEBI:58282
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_aaf28bcf_95e0_4bf1_9af7_ecfcce06d5bc
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P17568
name: NDUFB7
is encoded by: hsa:4713
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_083d1a96_955b_40a7_ac4e_1a686f8f1d97
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: P08559
type: Species
is: SBO:0000252
is encoded by: hsa:5160
name: PDHA1
initial amount: NaN

metaR NACASPtm
reactant: MODEL1310110038#
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_6f860e9e_8a0b_49ce_8dee_b483b5628171
type: Species
initial concentration: NaN
name: AK4
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:205
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_dd552a39_081f_4f82_9f46_0f1245764f16
has only substance units: false
name: IDH1
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: O75874
is encoded by: hsa:3417
is: SBO:0000252

metaR NACHEX21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176

metaR FUM
name: fumarase
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.2
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_527c3a5f_faa0_44e9_b46a_32593d881b28
is encoded by: hsa:3295
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: E9PB82
name: HSD17B4
is: SBO:0000252
initial concentration: NaN

metaR S23T2g
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
product: MODEL1310110038#
type: Reaction
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)

metaR r0424
is: SBO:0000176
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
reactant: MODEL1310110038#
fast: false
reversible: true
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM ac m
name: acetate
type: Species
constant: false
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
is: SBO:0000247
is: CHEBI:30089
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_e4c0b4f4_398d_4d37_940e_58099cfa4a67
is encoded by: hsa:8818
name: DPM2
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM 3sala m
has only substance units: false
is: C00606
initial amount: NaN
boundary condition: false
type: Species
name: 3-sulfino-L-alanine (1-)
initial concentration: 1.0
is: CHEBI:61085
is: SBO:0000247
constant: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaM estradiol e
is: SBO:0000247
type: Species
name: estradiol
initial amount: NaN
is: HMDB00151
is: CHEBI:16469
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
constant: false

metaM mal L x
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
name: (S)-malate(2-)
is: HMDB00156
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_75e99387_4e75_4555_ba6a_a4c6495836c3
initial amount: NaN
type: Species
is encoded by: hsa:7991
constant: false
name: TUSC3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q13454
boundary condition: true

metaR SUCCTD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR RAI1
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
fast: false
product: MODEL1310110038#
reversible: true
name: retinal isomerase (11-cis)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_ccefdd62_c82c_480d_b008_b3d95aec6685
is encoded by: hsa:BE966236
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: _BE966236_1_m

http://identifiers.org/biomodels.db/MODEL1310110038#_5a5e1242_6800_46d3_9d13_f52dac30f483
name: PISD
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23761
is: Q9UG56
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM hepcoa m
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
type: Species
has only substance units: false
name: heptanoylcoa
is: HMDB12969
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR BTNDm
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
kinetic law: MODEL1310110038#
type: Reaction
name: biotinidase (biotin), mitochondrial
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#

metaR UMPK7n
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaR FACOAL205
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
name: fatty-acid--CoA ligase
reactant: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110038#

metaR KSII CORE2t
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
name: keratan sulfate II (core2) transport, golgi to extracellular
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110038#

metaM ile L m
constant: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
is: SBO:0000247
is: HMDB00172
is: CHEBI:17191
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaM cspg e l
is: SBO:0000247
type: Species
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: HMDB02183
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:36005
initial concentration: 1.0

metaR r0423
type: Reaction
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
modifier: MODEL1310110038#
fast: false
is: SBO:0000176

metaR GLCNACT U
is: SBO:0000176
is described by: ECO:0000000
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
product: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110038#
reversible: false
fast: false

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaM hmgcoa c
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
name: Hydroxymethylglutaryl-CoA
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01375
is: CHEBI:15467

metaM arachdcrn c
has only substance units: false
is: HMDB01322
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
name: C20:4 carnitine
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

metaM odecoa m
initial amount: NaN
constant: false
is: CHEBI:57387
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
initial concentration: 1.0

metaR ALADGLNexR
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000304
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110038#
type: Reaction
reversible: true
name: L-alanine/glutamine reversible exchange

metaR 2AMADPTm
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_8a3b7e57_5b0a_4c30_b7ef_0292663375f5
is encoded by: hsa:2629
has only substance units: false
initial concentration: NaN
name: GBA
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR FACOAL206
fast: false
kinetic law: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110038#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110038#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
product: MODEL1310110038#

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_a9af5e55_21e1_4b5b_97dc_fe835aef4ba2
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: _W87865_1_c
has only substance units: false
is encoded by: hsa:W87865
is: SBO:0000252
type: Species

metaR r0422
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000

metaM ksi pre28 g
initial concentration: 1.0
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: SBO:0000247
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 28
is: C00130
is: HMDB00175
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110038#_e48f28ea_f6a2_4796_a05f_3dfc74a95ecc
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5208
name: PFKFB2
is: O60825
type: Species
initial amount: NaN
constant: false
is: SBO:0000252

metaM estradiol c
name: estradiol
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00151
initial concentration: 1.0
is: CHEBI:16469
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_702a5a5d_721f_449f_806b_9b486866a0ea
type: Species
is: Q8N4Q0
is encoded by: hsa:284273
initial concentration: NaN
is: SBO:0000252
name: ZADH2
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaR r0400
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: true
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

http://identifiers.org/biomodels.db/MODEL1310110038#_aac4e0a7_8712_4428_b3df_92ea65efb109
type: Species
is: P30837
name: ALDH1B1
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:219
constant: false
initial concentration: NaN

metaM occoa c
is: CHEBI:57386
initial amount: NaN
is: C01944
has only substance units: false
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
type: Species
initial concentration: 1.0

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110038#

metaR ACITL
is: SBO:0000176
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.8
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: ATP-Citrate lyase
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD

metaM trdox c
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
is: CHEBI:18191
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_d865616a_5d92_4e48_aa46_0a6cd9b02725
is encoded by: hsa:84706
is: Q8TD30
name: GPT2
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r1421
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
name: Free diffusion
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

metaR BIOCYTtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
product: MODEL1310110038#
name: biocytin transport, nuclear
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#

metaR DMHPTCRNCPT2
reversible: true
name: 2,6 dimethylheptanoly CoA carnitine transferase
reactant: MODEL1310110038#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
is described by: ECO:0000000

metaM HC02207 c
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-c2
is: SBO:0000247
constant: false
is: CHEBI:27555

metaR URATEt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110038#
fast: false
name: urate export from cytosol
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_f41e88a0_33a7_48fa_9061_d745a1b5890b
name: PIGQ
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:9091
is: Q9BRB3
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_eecbafc8_bc38_48f1_aa10_b116c0684592
name: AMPD2
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: E9PNG0
is encoded by: hsa:271

http://identifiers.org/biomodels.db/MODEL1310110038#_357bc35b_9788_40bd_b20a_ca5a5f0c15fa
initial amount: NaN
initial concentration: NaN
name: ALG2
is: SBO:0000252
constant: false
is encoded by: hsa:85365
is: Q9H553
boundary condition: true
type: Species
has only substance units: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM ocdececrn m
type: Species
boundary condition: false
is: HMDB06351
constant: false
initial amount: NaN
name: 11-octadecenoyl carnitine
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_1378bf2d_f291_48a1_9125_57e27456fce5
boundary condition: true
initial amount: NaN
name: PLD1
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5337
is: Q59EA4
is: SBO:0000252

metaR GLNASNNaEx
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
name: L-glutamine/L-asparagine Na-dependent exchange (Gln-L in)
is described by: ECO:0000269
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b3babd09_8ffc_48f5_8903_7ef3406e8a2e
type: Species
name: ITPA
is: Q9BY32
is encoded by: hsa:3704
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR RE2973C
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.137
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: RE2973
reversible: true
product: MODEL1310110038#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_48b1ff5f_6ffa_414e_a9ee_1dbfe4e71a4e
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:2713
name: GK3P
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM nad x
initial concentration: 1.0
is: C00003
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00902
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
type: Species
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_6b27e26f_faf2_4f39_a1f8_09e81046625e
initial concentration: NaN
initial amount: NaN
is: G3XAJ0
name: ACAD10
is encoded by: hsa:80724
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaM dtmp c
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:26999
is: HMDB01227
boundary condition: false
type: Species
is: C00364
initial amount: NaN
name: dTMP
has only substance units: false

metaR RE0827E
type: Reaction
name: RE0827
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false

metaR DM ethamp r
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM crn m
name: L-Carnitine
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: HMDB00062
is: C00318
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16347
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_44263345_4260_4f5d_918b_53a9ee516e06
has only substance units: false
is encoded by: hsa:6515
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: SLC2A3
is: P11169

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR DNDPt35m
is described by: ECO:0000269
type: Reaction
reversible: false
modifier: MODEL1310110038#
name: dGDP transport via dADP antiport
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR LEUKTRB4t
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110038#
is: SBO:0000185
type: Reaction
name: leukotriene B4 transport
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true

metaR FAEL183
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110038#
product: MODEL1310110038#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
fast: false
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: false

metaM lnlncacrn c
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06319
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
boundary condition: false
name: alpha-linolenyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110038#_fa767ea2_a849_494c_9adc_4382128b80ec
is: SBO:0000252
is encoded by: hsa:5161
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P29803
initial amount: NaN
initial concentration: NaN
name: PDHA2

metaR EX c101crn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaR CYOR u10m
is: SBO:0000185
modifier: MODEL1310110038#
name: ubiquinol-6 cytochrome c reductase, Complex III
product: MODEL1310110038#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.92

http://identifiers.org/biomodels.db/MODEL1310110038#_1cdd6ed1_5525_4663_9be8_5031acdc63d4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:2582
boundary condition: true
is: Q14376
constant: false
name: GALE
initial amount: NaN

metaR RE3628M
name: RE3628
fast: false
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110038#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_807d2156_3056_4fed_8b17_57a0db75f66f
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC26A6
initial concentration: NaN
boundary condition: true
is: Q9NQU1
has only substance units: false
type: Species
is encoded by: hsa:65010

metaR r0157
reversible: false
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.3.4.2
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_0605cb60_ead4_47c8_8bfb_19391e7ecaf0
is: Q5JAM2
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ALAS1
is encoded by: hsa:211
initial concentration: NaN

metaM nadph x
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
is: HMDB00221
is: SBO:0000247
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM docohepcoa m
constant: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaM pcrn m
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
is: http://identifiers.org/pubchem.compound/107738
type: Species
name: propionyl-carnitine
constant: false
initial amount: NaN
initial concentration: 1.0

metaM 5dhf e
constant: false
initial amount: NaN
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
type: Species
name: pentaglutamyl folate (DHF)
initial concentration: 1.0
is: SBO:0000247
is: HMDB06487
boundary condition: false
has only substance units: false

metaR ARACHt
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110038#

metaM dtmp e
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: dTMP(2-)
is: CHEBI:26999
is: HMDB01227
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

http://identifiers.org/biomodels.db/MODEL1310110038#_8590c852_d8df_4a22_8f8c_f8365e5e6675
is encoded by: hsa:7360
name: UGP2
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaR GLYCtm
fast: false
reactant: MODEL1310110038#
is: SBO:0000185
name: glycerol transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#

metaM dmnoncoa c
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB11604
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
is: SBO:0000247
boundary condition: false
name: 4,8 dimethylnonanoyl-CoA

metaR CHSTEROLtrc
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
kinetic law: MODEL1310110038#
name: transport of cholesterol into the cytosol
reversible: true

metaR CBR2
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
name: Carbonyl reductase [NADPH] 1
is version of: http://identifiers.org/ec-code/1.1.1.189
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b21649bf_e15a_431b_8b61_fc463b218744
is: B3KT84
boundary condition: true
name: SDR16C5
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:195814

http://identifiers.org/biomodels.db/MODEL1310110038#_eceb4aeb_35ef_4f60_afcb_e50c511435a5
is: SBO:0000252
is: P30520
is encoded by: hsa:159
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ADSS
type: Species
has only substance units: false
constant: false

metaR MG3er
reversible: false
is: SBO:0000176
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaR SERATB0tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Serine into the intestinal cells by ATB0 transporter
type: Reaction

metaM ksii core4 pre8 g
constant: false
is: CHEBI:58053
is: SBO:0000247
is: C00130
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 8
has only substance units: false
is: HMDB00175
type: Species
notes: FORMULA: C83H134N7O61SX CHARGE: -2
initial concentration: 1.0
initial amount: NaN

metaR NAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110038#
type: Reaction
reversible: true
name: sodium transport via diffusion (perioxisome)
kinetic law: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110038#
fast: false

metaM n2m2nm l
is: HMDB06529
is: SBO:0000247
name: n2m2nmasn (w/o peptide linkage)
type: Species
is: CHEBI:50570
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
has only substance units: false
initial concentration: 1.0

metaM dd2coa m
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
is: HMDB03712
type: Species
is: CHEBI:57330
has only substance units: false
name: trans-dodec-2-enoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
constant: false

metaM 56dthm c
is: CHEBI:27468
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial amount: NaN
is: SBO:0000247
is: HMDB00079
boundary condition: false
constant: false
has only substance units: false
name: 5,6-dihydrothymine
type: Species
initial concentration: 1.0

metaR TXA2tr
is: SBO:0000185
reversible: true
product: MODEL1310110038#
name: thromboxane A2 intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_1d5646cc_3270_4a9e_ac30_883280dddf1a
name: PDE4C
is: SBO:0000252
is encoded by: hsa:5143
has only substance units: false
constant: false
is: Q7KYS4
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaM thmpp c
is: SBO:0000247
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial concentration: 1.0
is: HMDB01372
constant: false
type: Species
is: CHEBI:45931
boundary condition: false
name: Thiamine diphosphate
is: C00068
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_edd51eb8_333e_4f4a_94da_babc094adb18
is encoded by: hsa:284273
is: SBO:0000252
has only substance units: false
name: ZADH2
initial amount: NaN
is: Q4G1C4
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR LEUtec
name: L-leucine transport via diffusion (extracellular to cytosol)
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110038#
fast: false
is: SBO:0000185
modifier: MODEL1310110038#
reversible: true
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c38f0992_b933_4ef6_8e6c_15c89ab406c4
is: SBO:0000252
is: B4E1R2
is encoded by: hsa:1491
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
name: CTH

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR FAOXC184x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR G6PDA
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: glucosamine-6-phosphate deaminase
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.99.6
is: SBO:0000176
reversible: false
modifier: MODEL1310110038#
type: Reaction

metaR GLYK
is: SBO:0000176
name: glycerol kinase
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.30
reversible: false
type: Reaction
fast: false
is described by: ECO:0000269

metaM zymst r
initial amount: NaN
type: Species
is: HMDB06271
constant: false
is: CHEBI:18252
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
name: zymosterol
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM o2 c
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
initial concentration: 1.0
name: O2
is: CHEBI:15379
is: HMDB01377
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

metaM 4hbzcoa m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
has only substance units: false
is: HMDB06467
name: 4-hydroxybenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110038#_c6364b3f_c9b8_4129_ad7b_4949f35b93b2
is: SBO:0000252
name: GALNT8
is: Q9NY28
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:26290

metaM hpdcacrn m
constant: false
has only substance units: false
name: heptadecanoyl carnitine
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
is: HMDB06210
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_eaa5b07c_fddc_4e70_8f83_97cf7674882d
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:50940
initial amount: NaN
is: Q9HCR9
has only substance units: false
name: PDE11A

metaR r1538
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_02428674_1de6_4f40_8c8e_274db96eabca
is: SBO:0000252
constant: false
name: PFKFB4
initial amount: NaN
boundary condition: true
is encoded by: hsa:5210
initial concentration: NaN
is: Q16877
type: Species
has only substance units: false

metaM gln L c
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
name: L-glutamine
boundary condition: false

metaR S4TASE5ly
fast: false
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_88e2c0c3_8fd7_4a83_9976_aaa34fac37e4
type: Species
is: SBO:0000252
is: Q16795
constant: false
boundary condition: true
name: NDUFA9
initial amount: NaN
has only substance units: false
is encoded by: hsa:4704
initial concentration: NaN

metaM thexddcoa m
is: HMDB02288
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: trans7,10-hexadecadienoylcoa
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
boundary condition: false
type: Species

metaM c12dccoa c
initial concentration: 1.0
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
type: Species
constant: false
has only substance units: false
is: HMDB00623
name: dodecanedioylcoa
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR RE2655R
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110038#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2655

metaR RE3520E
fast: false
name: RE3520
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
kinetic law: MODEL1310110038#

metaR r1749
is: SBO:0000185
reactant: MODEL1310110038#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_e9d120d9_e6dc_4d83_9dd4_1a9d047e3f75
is: SBO:0000252
has only substance units: false
is: Q8IX04
initial concentration: NaN
initial amount: NaN
name: UEVLD
is encoded by: hsa:55293
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1d2fcf93_5a87_4421_b6ae_56957e11c933
is: Q96FL9
is encoded by: hsa:79623
has only substance units: false
is: SBO:0000252
constant: false
name: GALNT14
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_ab6f8791_0321_41da_8954_e11440086588
boundary condition: true
initial concentration: NaN
name: COX6B2
is: SBO:0000252
initial amount: NaN
is: Q6YFQ2
is encoded by: hsa:125965
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b92bce06_95b4_4853_ae66_7ebdbaf83226
initial amount: NaN
is encoded by: hsa:622
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: BDH1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_906ae662_c956_42d0_8550_d328db4fee4b
is: SBO:0000252
initial concentration: NaN
is: O95436
name: SLC34A2
initial amount: NaN
has only substance units: false
is encoded by: hsa:10568
type: Species
constant: false
boundary condition: true

metaR SPODMm
type: Reaction
name: superoxide dismutase
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is described by: ECO:0000304
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
reversible: false

metaM c6crn c
type: Species
notes: FORMULA: C13H25NO4 CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247
name: hexanoyl carnitine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00705

metaM ksii core2 deg3 l
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
initial amount: NaN
is: HMDB00143
is: CHEBI:12936
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 3
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b3a3dc98_2507_4dfb_94e4_91d9ea93f30a
is: Q99714
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: HSD17B10
type: Species
is encoded by: hsa:3028

http://identifiers.org/biomodels.db/MODEL1310110038#_45253649_a795_4a54_b301_c98e2bdab3ab
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: _FLJ44968_1_m
is encoded by: hsa:FLJ44968
is: SBO:0000252
constant: false

metaM o2 e
constant: false
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
is: SBO:0000247
is: HMDB01377
is: CHEBI:15379
initial concentration: 1.0
name: O2
boundary condition: false
type: Species
is: C00007

metaR G14T17g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaM 3hexdcoa c
constant: false
has only substance units: false
name: 3-hydroxyhexadecanoylcoa
type: Species
boundary condition: false
is: C05258
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
is: HMDB03932
initial amount: NaN

metaM omhpal r
name: w-hydroxypalmiticacid
constant: false
is: HMDB06294
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1

metaR PFK26
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.105
type: Reaction
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
fast: false
kinetic law: MODEL1310110038#
name: 6-phosphofructo-2-kinase
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000000

metaR RE1903R
type: Reaction
reversible: true
kinetic law: MODEL1310110038#
fast: false
name: RE1903
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reactant: MODEL1310110038#

metaR C4x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaM pep m
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Phosphoenolpyruvate
is: HMDB00263
is: C00074
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: CHEBI:18021

metaM pcrn x
constant: false
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
name: propionyl-carnitine
is: HMDB00824
is: http://identifiers.org/pubchem.compound/107738
initial concentration: 1.0

metaM nadph m
is: SBO:0000247
boundary condition: false
is: CHEBI:57783
has only substance units: false
initial amount: NaN
is: HMDB00221
type: Species
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaR r1428
product: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
is: SBO:0000185
name: Free diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110038#

metaR r2079
is: SBO:0000185
type: Reaction
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_7727a60e_a438_4f81_8ba1_3ad43f5218b1
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI631997_1_m
is encoded by: hsa:AI631997
type: Species
constant: false
initial concentration: NaN

metaM phytcoa c
is: HMDB01359
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:57391
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
name: phytanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110038#_7eefed5b_a056_4527_b5d7_305c5cc83b44
is encoded by: hsa:BG035985
initial amount: NaN
name: _BG035985_1_c
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR GK1
fast: false
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
reversible: true
name: guanylate kinase (GMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM ocdececrn c
boundary condition: false
name: 11-octadecenoyl carnitine
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C25H47NO4 CHARGE: 0
has only substance units: false
initial amount: NaN
is: HMDB06351

metaR q10tm
product: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
name: transport of ubiquinone into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false

metaR r2506
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: true
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110038#

metaM pnto R e
boundary condition: false
is: HMDB00210
initial amount: NaN
is: CHEBI:7916
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
name: (R)-Pantothenate

metaR r0917
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000

metaR r1429
type: Reaction
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110038#
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true

metaR DOPAtu
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reversible: true
name: Dopamine uniport
kinetic law: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_f506b98e_0cfa_4c6d_b2ce_5bd2bd3cf2cd
is: B4DP47
has only substance units: false
initial concentration: NaN
name: BCKDHA
initial amount: NaN
boundary condition: true
is encoded by: hsa:593
constant: false
type: Species
is: SBO:0000252

metaM 3hexdtricoa m
initial amount: NaN
boundary condition: false
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02288
type: Species
initial concentration: 1.0

metaM dlnlcgcoa c
name: dihomo-gamma-linolenyl coenzyme A
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
initial concentration: 1.0
is: CHEBI:27979

metaM nrpphr e
initial amount: NaN
is: HMDB00216
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: CHEBI:33569
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a239f280_7f6e_438a_b231_06121acb00ad
is: SBO:0000252
is encoded by: hsa:H53099
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: _H53099_1_m
has only substance units: false

metaM dcsptn1coa x
is: SBO:0000247
is: HMDB06513
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/47205483

metaM dhcholestanate r
has only substance units: false
type: Species
is: CHEBI:16577
is: HMDB00359
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_46e646a9_ea75_4b10_95bf_56518fd291c7
is encoded by: hsa:H77542
initial amount: NaN
is: SBO:0000252
constant: false
name: _H77542_1_r
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR ASCBt4
product: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
name: L-ascorbate transport via proton symport
kinetic law: MODEL1310110038#
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110038#
type: Reaction

metaM dece3coa x
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
name: 3-decenoylcoa
initial concentration: 1.0
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM HC02121 c
boundary condition: false
type: Species
is: CHEBI:58758
name: S-(hydroxymethyl)glutathione(1-)
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_55cf7fbf_88d1_4728_a0de_df5c7918212b
type: Species
initial amount: NaN
initial concentration: NaN
is: Q96NR8
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: RDH12
is encoded by: hsa:145226

metaR RE1342C
name: RE1342
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#

metaM tmndnccrn c
has only substance units: false
constant: false
name: Timnodonyl carnitine
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16987
type: Species
is: HMDB12130
boundary condition: false
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1

metaR PGISr
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.99.4
is described by: ECO:0000134
name: Prostaglandin I2 synthase
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ

metaM HC10852 r
boundary condition: false
initial amount: NaN
name: palmitoleyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:61540
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_87de7458_9a57_407a_9abf_fd38623bc46b
has only substance units: false
initial amount: NaN
is encoded by: hsa:4710
name: NDUFB4
is: SBO:0000252
is: O95168
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaM nrpphr c
initial amount: NaN
constant: false
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00216
is: SBO:0000247
is: CHEBI:33569

http://identifiers.org/biomodels.db/MODEL1310110038#_7bef21d3_bdd4_4b35_a868_02f262f80ffd
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9Y2A9
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:10331
name: B3GNT3

metaR S2TASE3ly
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.6.13
kinetic law: MODEL1310110038#
name: iduronate-2-sulfatase, lysosomal
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#

metaM gln L e
constant: false
boundary condition: false
is: CHEBI:18050
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
name: L-glutamine
is: HMDB00641
initial amount: NaN
has only substance units: false
type: Species

metaM dtmp m
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01227
is: CHEBI:26999
name: dTMP
has only substance units: false
initial concentration: 1.0
is: C00364
constant: false
boundary condition: false

metaR r0915
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM pnto R c
boundary condition: false
is: HMDB00210
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
is: CHEBI:7916
constant: false
name: (R)-Pantothenate
is: SBO:0000247
type: Species

metaM nad r
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00902
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57540
name: NAD(1-)
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
constant: false

metaR FAOXC184m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_05aa210e_988e_4d52_a43e_559e47b3794a
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q8N3T1
is: SBO:0000252
is encoded by: hsa:117248
name: GALNTL2
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_dc735909_9693_4f3c_b6f0_63ce4c4211cb
initial amount: NaN
is encoded by: hsa:215
constant: false
has only substance units: false
type: Species
boundary condition: true
is: P33897
name: ABCD1
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_1b30b143_dab3_400a_8a4f_5caa75a0b035
name: AK7
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:122481
is: SBO:0000252
has only substance units: false
is: Q96M32

http://identifiers.org/biomodels.db/MODEL1310110038#_ccb84399_1ef4_4635_9375_5d930602ad81
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q86U05
has only substance units: false
type: Species
constant: false
name: SLC7A8
is encoded by: hsa:23428
boundary condition: true

metaR AMPDA
is version of: http://identifiers.org/ec-code/3.5.4.6
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
type: Reaction
name: Adenosine monophosphate deaminase
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
is described by: ECO:0000269

metaM 44mzym r
is: SBO:0000247
constant: false
name: 14-demethyllanosterol
initial concentration: 1.0
initial amount: NaN
is: HMDB01286
type: Species
has only substance units: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: CHEBI:18364
boundary condition: false

metaR r1638
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_ca9ee278_609a_474c_82a8_07267f0135fa
has only substance units: false
constant: false
is: E9KL44
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3030
type: Species
name: HADHA
is: SBO:0000252
boundary condition: true

metaM malt e
type: Species
is: HMDB00163
is: C00208
is: CHEBI:17306
constant: false
is: SBO:0000247
name: Maltose
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
boundary condition: false

metaR FAOXC123C102m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR NADtpu
is: SBO:0000185
is described by: ECO:0000000
name: NAD transporter, peroxisome
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110038#
fast: false
reversible: false
reactant: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_3a0cde01_d67a_4bab_ade8_6d8789146fe0
boundary condition: true
initial amount: NaN
name: FASN
constant: false
type: Species
is encoded by: hsa:2194
is: SBO:0000252
has only substance units: false
is: P49327
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_87751dd6_89b9_4e8f_a87a_8cca3fce8a3a
type: Species
is: P31639
boundary condition: true
is: SBO:0000252
name: SLC5A2
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6524

metaR C142OHc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d78b90cf_14f0_46ff_af0a_a449091d8266
type: Species
is: Q15735
is: SBO:0000252
is encoded by: hsa:27124
name: INPP5J
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR ACOAD1fm
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110038#_61e5343f_250a_4bc5_82ae_af850f981489
type: Species
is: SBO:0000252
is: Q9P0Z9
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:51268
name: PIPOX

metaM hdd2coa x
constant: false
type: Species
is: HMDB03945
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61526
has only substance units: false
name: (E)-hexadec-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110038#_9d58b226_0be6_4190_84bb_9e0dd9a2f515
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:515
type: Species
constant: false
name: ATP5F1
is: Q08ET0
initial concentration: NaN

metaR r1639
reversible: true
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#

metaR PMANM
kinetic law: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
name: phosphomannomutase
type: Reaction
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.8

metaM nadph r
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00005
initial concentration: 1.0
is: CHEBI:57783
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
is: HMDB00221

metaR DGAT
name: diacylglycerol acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.20
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
fast: false
reactant: MODEL1310110038#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_54f9e396_e04c_4afc_97df_ee29f2fb33f1
constant: false
is encoded by: hsa:284098
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PIGW
is: Q7Z7B1
initial amount: NaN
has only substance units: false

metaM 3tetd7ecoa m
constant: false
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB05066
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4

metaM malt c
type: Species
is: HMDB00163
name: Maltose
is: CHEBI:17306
is: C00208
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r1636
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110038#
type: Reaction

metaM crn r
has only substance units: false
initial amount: NaN
is: CHEBI:16347
constant: false
name: (R)-carnitine
boundary condition: false
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR SPODMe
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
name: superoxide dismutase, extracellular
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
fast: false

metaR C142OHe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaM nad m
boundary condition: false
constant: false
name: Nicotinamide adenine dinucleotide
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
is: CHEBI:57540
type: Species
is: HMDB00902
initial concentration: 1.0
has only substance units: false
is: C00003
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_45ef601a_4dba_44b7_af57_be085c297dbf
has only substance units: false
boundary condition: true
is: P07954
is: SBO:0000252
constant: false
is encoded by: hsa:2271
initial concentration: NaN
initial amount: NaN
type: Species
name: FH

metaM hpdcacrn c
has only substance units: false
initial amount: NaN
is: HMDB06210
is: SBO:0000247
name: heptadecanoyl carnitine
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3

metaR UMPK6n
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
fast: false
name: UMP kinase (dCTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110038#_8272db74_7028_4c4b_abbf_c21cd9e0da69
has part: P24311
is encoded by: hsa:341947
has part: P00414
has only substance units: false
has part: P13073
is encoded by: hsa:1347
has part: P15954
is encoded by: hsa:4514
is encoded by: hsa:1329
is encoded by: hsa:1340
constant: false
has part: Q96KJ9
has part: Q7GXY8
is encoded by: hsa:9377
has part: Q02221
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1339
is encoded by: hsa:9167
is encoded by: hsa:1327
is encoded by: hsa:1349
is encoded by: hsa:1337
is encoded by: hsa:125965
is encoded by: hsa:4512
is encoded by: hsa:1346
type: Species
is encoded by: hsa:1351
is encoded by: hsa:4513
initial concentration: NaN
has part: Q6FGA0
is encoded by: hsa:170712
is encoded by: hsa:84701
boundary condition: true
has part: Q8TF08
is: SBO:0000297
has part: P09669
has part: P20674
has part: Q7GXZ8
has part: Q53YB7
has part: H0UI06
has part: Q7Z4L0
has part: P24310
is encoded by: hsa:1345
is encoded by: hsa:1350
initial amount: NaN
has part: Q53XN1
has part: Q6YFQ2
has part: P12074
has part: P14854

metaM dd2coa x
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
constant: false
boundary condition: false
is: HMDB03712
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:57330
is: SBO:0000247

metaM HC01115 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:29025
name: NeuNGc
initial amount: NaN
constant: false

metaM pa hs n
is: CHEBI:57739
name: phosphatidate(2-)
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

metaM but m
has only substance units: false
initial concentration: 1.0
is: CHEBI:17968
is: HMDB00039
name: butyrate
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaM fum m
has only substance units: false
is: CHEBI:29806
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial amount: NaN
name: Fumarate
is: HMDB00134
is: C00122
boundary condition: false
constant: false
type: Species

metaR THMMPtm
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
type: Reaction
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
is: SBO:0000185
name: Thiamine monophosphate transport, mitochondrial

metaM 5tedtricoa x
is: HMDB02288
type: Species
constant: false
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r1637
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: true
is: SBO:0000185

metaR PSt3
name: phosphatidylserine transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_b227822c_e97b_4e4c_ad5f_36d10a8130bf
is encoded by: hsa:2348
has only substance units: false
type: Species
name: FOLR1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR ESTRADIOLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: estradiol intracellular transport
product: MODEL1310110038#
type: Reaction
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e320b952_7553_4752_b9c1_998b0945708d
type: Species
initial amount: NaN
is encoded by: hsa:5281
initial concentration: NaN
constant: false
is: SBO:0000297
has part: Q8TEQ8
boundary condition: true
is encoded by: hsa:84720
name: PIGF:PIGO
has only substance units: false
has part: Q07326

http://identifiers.org/biomodels.db/MODEL1310110038#_45ecc4df_79c8_4a37_8430_cf03a7ccbf72
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:277
name: AMY1B
initial concentration: NaN
is: P04745
constant: false

metaR FAOXC160
is described by: ECO:0000269
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110038#
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
type: Reaction
reactant: MODEL1310110038#

metaR HISTAtu
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
fast: false
name: Histamine uniport
is described by: ECO:0000269
reactant: MODEL1310110038#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
has only substance units: false
name: prostaglandin-c2
type: Species
is: CHEBI:27555
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_07db2967_46b4_4da7_aaf9_d308d7e79202
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: MTMR2
constant: false
is: A6NN98
is encoded by: hsa:8898

http://identifiers.org/biomodels.db/MODEL1310110038#_b3ed5228_7def_43be_b345_707ded94f472
is encoded by: hsa:11212
constant: false
name: PROSC
is: O94903
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM pa hs m
constant: false
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
name: phosphatidate(2-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM grdp x
constant: false
name: geranyl diphosphate(3-)
is: SBO:0000247
has only substance units: false
is: HMDB01285
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
type: Species
initial concentration: 1.0
is: CHEBI:58057

metaR AG13T8g
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110038#

metaM C02470 c
initial amount: NaN
type: Species
is: HMDB00881
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5485
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
boundary condition: false
initial concentration: 1.0
constant: false
name: Xanthurenic acid
is: C02470
has only substance units: false

metaR PRO1xm
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
name: proline oxidase (NAD), mitochondrial
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000254
reactant: MODEL1310110038#
is: SBO:0000176
reversible: false

metaR r0268
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
kinetic law: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110038#

metaR AG13T7g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110038#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM dctp m
constant: false
is: CHEBI:16311
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
has only substance units: false
name: dCTP
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00458
boundary condition: false
initial amount: NaN
is: HMDB00998

metaR r2081
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110038#
fast: false

metaR FAOXC123C102x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaM 2oxoadp c
is: CHEBI:57499
initial concentration: 1.0
boundary condition: false
is: HMDB00225
constant: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: 2-oxoadipate(2-)

http://identifiers.org/biomodels.db/MODEL1310110038#_bb80df8c_14ec_48c6_95de_498d385f6000
name: GALNT6
type: Species
constant: false
is: Q8NCL4
is encoded by: hsa:11226
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaR NRPPHRt4 2 r
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185
name: Norepinephrine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110038#

metaR r2082
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110038#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_295a6f32_00e7_471e_a12f_7ff16ab6d78b
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:27034
initial concentration: NaN
constant: false
is: Q6ZWP6
name: ACAD8
boundary condition: true

metaR r1647
is: SBO:0000185
modifier: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_6956b9fd_302d_4b85_9e86_a49607ea5076
has only substance units: false
name: B3GNT8
is: SBO:0000252
type: Species
is: Q7Z7M8
constant: false
initial amount: NaN
is encoded by: hsa:374907
boundary condition: true
initial concentration: NaN

metaM hdcecrn m
is: HMDB00222
is: SBO:0000247
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
name: Hexadecenoyl carnitine
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaM pep c
is: HMDB00263
initial amount: NaN
name: Phosphoenolpyruvate
has only substance units: false
constant: false
boundary condition: false
is: C00074
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: CHEBI:18021

metaM 3pg c
is: C00197
is: http://identifiers.org/pubchem.compound/3497
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58272
initial amount: NaN
name: 3-Phospho-D-glycerate
is: HMDB00807

http://identifiers.org/biomodels.db/MODEL1310110038#_c8c60074_e6b4_430d_8fb6_629df2349da5
is encoded by: hsa:2678
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: P19440
constant: false
initial amount: NaN
has only substance units: false
name: GGT1

http://identifiers.org/biomodels.db/MODEL1310110038#_6030be36_db76_4b15_89af_d415a162dacb
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFB10
is encoded by: hsa:4716
is: SBO:0000252
constant: false
boundary condition: true
is: A8K761
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_729e238b_06fc_4c79_9fb9_0524113f1caa
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFB3
is encoded by: hsa:4709
is: Q6IB80
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_3054c334_a157_4611_9bba_525948fcbcaa
is encoded by: hsa:2109
has part: P38117
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000297
has only substance units: false
name: ETFA:ETFB

metaR r1646
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110038#
reversible: true

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaM dctp n
has only substance units: false
is: C00458
boundary condition: false
is: CHEBI:16311
type: Species
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
is: HMDB00998
name: dCTP
constant: false
initial concentration: 1.0

metaR TYRCBOX
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110038#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110038#
name: L-Tyrosine carboxy-lyase
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR C6DCc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM ade c
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:16708
type: Species
name: Adenine
is: HMDB00034
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00147

metaR C12OHc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaR A MANASEly
fast: false
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is: SBO:0000176
name: alpha-mannosidase, lysosomal
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.24
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110038#
type: Reaction

metaR EX 3ivcrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR r2083
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR ASNSERNaEx
reactant: MODEL1310110038#
name: L-serine/L-asparagine Na-dependent exchange (Asn-L in)
reversible: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false

metaM ksi l
initial concentration: 1.0
is: C00445
is: CHEBI:57455
is: SBO:0000247
name: keratan sulfate I
initial amount: NaN
is: HMDB01354
has only substance units: false
boundary condition: false
type: Species
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

metaR r1645
kinetic law: MODEL1310110038#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaM dhcholestanate x
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
is: HMDB00359
initial concentration: 1.0
type: Species
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
is: SBO:0000247
is: CHEBI:16577

http://identifiers.org/biomodels.db/MODEL1310110038#_85c48c75_b8c1_48f7_ab1d_167be3c1f138
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: _AI697028_1_m
constant: false
is encoded by: hsa:AI697028

http://identifiers.org/biomodels.db/MODEL1310110038#_bd8d29b7_42e0_4f2a_a2a8_9d03108fcf47
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:8613
initial amount: NaN
constant: false
name: PPAP2B
is: SBO:0000252
initial concentration: NaN
is: O14495

http://identifiers.org/biomodels.db/MODEL1310110038#_c2185d64_5c0e_42b0_a769_751db410f2f9
is encoded by: hsa:9563
name: H6PD
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: O95479
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_fcbc436c_5a51_45cb_a344_ab07cf48a648
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:374907
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: B3GNT8

metaR r2084
kinetic law: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110038#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#

metaR RE0935E
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: RE0935
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_c5395a7d_a7a1_441c_a9d6_d1a9c302781b
is: SBO:0000252
initial amount: NaN
constant: false
name: PFKFB1
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:5207
initial concentration: NaN
is: P16118

metaR HPCLx
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
name: 2-hydroxyphytanoyl-CoA lyase

metaR r1644
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_157f1e44_c755_4697_ad48_f11310058a77
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P15291
type: Species
is encoded by: hsa:2683
name: B4GALT1
initial amount: NaN
constant: false

metaR ARACHDt2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_01202cb6_6898_42a0_a734_7caa37bb5841
name: NDUFS1
initial concentration: NaN
is: SBO:0000252
is: P28331
is encoded by: hsa:4719
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM eitetcoa x
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
name: 5,8,11,14-eicosatetraenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial amount: NaN

metaR r2085
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110038#_1b493ba2_c60b_46af_9379_f7846ceee6b5
is: Q9NY59
constant: false
initial concentration: NaN
has only substance units: false
name: SMPD3
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:55512

metaM lgt S c
boundary condition: false
constant: false
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
initial concentration: 1.0
initial amount: NaN
is: HMDB01066
is: SBO:0000247
name: (R)-S-lactoylglutathionate(1-)
type: Species
is: CHEBI:57474
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_f995aa4b_2ebe_46a2_8b46_58567f5bc9f3
initial concentration: NaN
initial amount: NaN
type: Species
name: CMPK1
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:51727
is: B2R6S5
has only substance units: false

metaM ksii core2 deg6 l
is: CHEBI:12936
is: SBO:0000247
type: Species
notes: FORMULA: C44H72N4O33SX CHARGE: -1
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
constant: false
name: keratan sulfate II (core 2-linked), degradation product 6

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaM nrpphrsf e
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
is: SBO:0000247
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial concentration: 1.0
name: Sulfate derivative of norepinephrine
is: HMDB02062
type: Species
initial amount: NaN
has only substance units: false

metaR CYSGLYexR
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true
name: L-cysteine/glycine reversible exchanger

metaM tetd7ecoa m
constant: false
name: 7-tetradecenoylcoa
type: Species
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB13109
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e84c5649_9d38_4f8d_9184_59c20e245aba
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: MGAM
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8972
is: O43451
type: Species

metaR r1643
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110038#
product: MODEL1310110038#

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_586e49df_0c81_4ad5_b77a_a5ab8554e4a3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5151
constant: false
initial concentration: NaN
name: PDE8A
initial amount: NaN
has only substance units: false
type: Species

metaR FAOXC121C10x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR RE1523M
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1523
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true

metaR NDPK6n
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000304
type: Reaction

metaR MEVK1x
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.36
is described by: ECO:0000134
name: mevalonate kinase (atp)
reversible: false
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176

metaR RE2972M
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
product: MODEL1310110038#
name: RE2972
is version of: http://identifiers.org/ec-code/2.7.1.67
is: SBO:0000176
modifier: MODEL1310110038#

metaM but c
type: Species
constant: false
has only substance units: false
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00039

metaR r0913
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_a5cc446d_fe2d_4173_b526_1ef4b16062b2
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: NDUFA10
is: O95299
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4705

metaM fum c
is: C00122
name: Fumarate
is: HMDB00134
initial concentration: 1.0
has only substance units: false
is: CHEBI:29806
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

metaR FAOXC226C227m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaR r1642
modifier: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#

metaR MI145PK
product: MODEL1310110038#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
modifier: MODEL1310110038#
is: SBO:0000176
type: Reaction
reversible: false
name: inositol-1,4,5-trisphosphate 3-kinase
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.127

metaM 3mlda e
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: SBO:0000247
type: Species
is: HMDB02820
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C05828
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
name: 3-Methylimidazoleacetic acid
constant: false

metaR RETH
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
name: retinyl ester hydrolase
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: false
type: Reaction

metaM nad c
constant: false
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
is: C00003
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0

metaR DOLK L
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.7.1.108 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: false
name: Dolichol kinase, human (liver)
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_b2375082_a72d_4749_afbc_8125e65d4e70
initial concentration: NaN
is encoded by: hsa:7296
name: TXNRD1
boundary condition: true
is: Q16881
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaM ksi pre9 g
is: SBO:0000247
initial concentration: 1.0
is: C00130
is: HMDB00175
boundary condition: false
has only substance units: false
is: CHEBI:58053
constant: false
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
name: keratan sulfate I biosynthesis, precursor 9
type: Species
initial amount: NaN

metaM leuktrE4 c
is: HMDB02200
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: leukotriene E4(1-)

metaM HC01401 x
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:27668
constant: false
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

http://identifiers.org/biomodels.db/MODEL1310110038#_db9cb5fc_583c_4d5a_b3df_cea04eed1e4e
name: MAT2B:MAT2A
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:27430
constant: false
is encoded by: hsa:4144
has part: P31153
initial amount: NaN
has only substance units: false
is: SBO:0000297

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR NMNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
reversible: false
name: NMN synthetase
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_8f3b1926_063a_4761_ac5b_cd983c0d56e6
is: O43570
initial concentration: NaN
name: CA12
constant: false
initial amount: NaN
is encoded by: hsa:771
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaR r1641
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false

metaR TETTET6t
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
fast: false
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110038#_6c6b677f_9592_4ddb_9802_c617870f7eff
type: Species
is encoded by: hsa:2584
initial concentration: NaN
name: GALK1
is: SBO:0000252
has only substance units: false
is: P51570
initial amount: NaN
boundary condition: true
constant: false

metaR DURIt
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
reactant: MODEL1310110038#
is: SBO:0000185
name: deoxyuridine transport via diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaM but e
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00039
initial concentration: 1.0
has only substance units: false
is: CHEBI:17968
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_83c7117c_fe22_4259_8cf8_3db51dd437fc
is: P30084
initial concentration: NaN
is encoded by: hsa:1892
name: ECHS1
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e0dd96b5_4a0c_479d_85bc_eb98e0bf0410
boundary condition: true
name: TM7SF2
initial amount: NaN
constant: false
has only substance units: false
is: O76062
is encoded by: hsa:7108
initial concentration: NaN
type: Species
is: SBO:0000252

metaM dcsptn1coa m
is: HMDB06513
is: C16173
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR C12DCACOT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_e0cd61b1_5cd4_40a4_9013_5f0e41709ac3
constant: false
initial amount: NaN
boundary condition: true
name: ENPP1
is: SBO:0000252
is: P22413
is encoded by: hsa:5167
has only substance units: false
type: Species
initial concentration: NaN

metaR NODe
name: NODe
fast: false
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000134
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r2080
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#

metaM cs e deg2 l
is: HMDB00812
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
constant: false
is: CHEBI:16953
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_085f3610_e187_40bb_8d46_ebf84b126583
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: P35219
has only substance units: false
type: Species
is encoded by: hsa:767
name: CA8

metaR r1640
reactant: MODEL1310110038#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_6efcb0c3_3581_426b_8a67_eab0a3252f43
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB
has part: P21953
constant: false
is encoded by: hsa:593
has part: P11182
initial concentration: NaN
has part: B4DP47
has only substance units: false
is encoded by: hsa:594
is encoded by: hsa:1629

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaR r0267
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.9
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
product: MODEL1310110038#
fast: false
reversible: true
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

metaR SMS
kinetic law: MODEL1310110038#
fast: false
reversible: false
name: Sphingomyelin synthase (homo sapiens)
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.27

metaR r1418
product: MODEL1310110038#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
type: Reaction

metaR PI45P3K
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
kinetic law: MODEL1310110038#
fast: false
reversible: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.153

metaM psyltchol e
initial concentration: 1.0
notes: FORMULA: C9642032H15428745NO8667421S CHARGE: 0
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/94244
constant: false
name: psyllium-taurocholic acid complex
has only substance units: false
boundary condition: false

metaR HOCDACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR CHATn
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: Choline O-acetyltransferase
reversible: true
reactant: MODEL1310110038#
is: SBO:0000176

metaM 1pyr5c c
initial amount: NaN
initial concentration: 1.0
is: C03912
is: CHEBI:15893
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
constant: false
name: 1-Pyrroline-5-carboxylate

metaR UDPGLCAter
reactant: MODEL1310110038#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
fast: false
product: MODEL1310110038#

metaM m7mpdol U r
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
is: CHEBI:37636
constant: false
boundary condition: false
has only substance units: false
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247

metaR NDPK6m
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaR CYTK11n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
modifier: MODEL1310110038#
name: cytidylate kinase (dCMP,dGTP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM ksii core4 pre10 g
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:28067
type: Species
name: keratan sulfate II biosynthesis, precursor 10

metaM occoa m
initial amount: NaN
is: HMDB01070
has only substance units: false
is: CHEBI:57386
is: C01944
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
initial concentration: 1.0
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: SBO:0000247

metaM s2l2fn2m2masn e
is: C00255
is: HMDB00244
boundary condition: false
notes: FORMULA: C90H145N6O65X CHARGE: -2
has only substance units: false
initial concentration: 1.0
name: PA6
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:3554

metaM so4 e
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: HMDB01448
is: SBO:0000247
has only substance units: false
name: sulfate
is: CHEBI:16189
boundary condition: false
constant: false
initial amount: NaN

metaM ksi e
is: CHEBI:17268
initial concentration: 1.0
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
constant: false
type: Species
is: SBO:0000247
is: HMDB00211
has only substance units: false
initial amount: NaN
boundary condition: false

metaR HSD3B11
reversible: false
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is described by: ECO:0000134
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_293b694f_1aee_469a_8a95_ade857102bfb
initial concentration: NaN
initial amount: NaN
type: Species
name: DGKI
is encoded by: hsa:9162
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: O75912

http://identifiers.org/biomodels.db/MODEL1310110038#_b35566c4_3061_4a88_9f08_4f80206cd4d8
initial amount: NaN
name: HMGCL
is: SBO:0000252
is: Q6IBC0
is encoded by: hsa:3155
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_92f44aae_28f0_4297_b642_967760dd45d3
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54963
initial amount: NaN
type: Species
is: Q53HM1
name: UCKL1
boundary condition: true

metaM 1pyr5c m
is: SBO:0000247
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:15893
initial amount: NaN
is: C03912
initial concentration: 1.0
is: HMDB01301

metaR FATP2t
reactant: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110038#_99a75a5d_ce67_41fd_99fb_a2e6a918ec13
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: UGT1A8
constant: false
is encoded by: hsa:54576
boundary condition: true
initial amount: NaN
is: Q5DSZ6

metaR NACHEX22ly
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
is: HMDB00464
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:29108
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_edd874cb_b71e_4598_9078_8ec5916c10f3
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P56381
is encoded by: hsa:514
name: ATP5E
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_4cb36106_d31f_4fa9_97cc_27bf34dbc501
has only substance units: false
boundary condition: true
is: A7E2E0
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5293
type: Species
is: SBO:0000252
name: PIK3CD

metaM val L m
type: Species
name: L-valine
is: CHEBI:16414
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00883
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
constant: false

metaM lnlncgcrn m
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06318
name: gamma-linolenyl carnitine
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110038#_883d7319_f7f7_4dcd_8a21_589fbb7c9ab0
constant: false
initial amount: NaN
is encoded by: hsa:D87002
name: _D87002_1_m
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaM arachcrn c
is: SBO:0000247
type: Species
initial concentration: 1.0
name: arachidyl carnitine
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06460
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

http://identifiers.org/biomodels.db/MODEL1310110038#_d4e9e6a4_ebfd_49f5_b85b_ce97f359d7ae
is: SBO:0000252
has only substance units: false
is: Q96P26
is encoded by: hsa:93034
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: NT5C1B

metaM 4nphsf e
type: Species
is: HMDB06492
constant: false
has only substance units: false
is: CHEBI:35422
initial amount: NaN
name: 4-Nitrophenyl sulfate
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
boundary condition: false
initial concentration: 1.0

metaR RE3241R
name: RE3241
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110038#
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction

metaM udpglcur r
boundary condition: false
name: UDP-D-glucuronate
is: C00167
is: CHEBI:58052
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: HMDB00935
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM crn c
constant: false
has only substance units: false
is: CHEBI:16347
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
name: L-Carnitine
initial amount: NaN
is: HMDB00062
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_8b7dd4fe_1443_40e2_8a21_03d89512f540
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3939
constant: false
name: LDHA
initial concentration: NaN
is: SBO:0000252
is: P00338
type: Species

metaM dctp c
initial amount: NaN
type: Species
is: CHEBI:16311
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
is: SBO:0000247
name: dCTP
boundary condition: false
is: HMDB00998
is: C00458

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM orot5p c
is: HMDB00218
initial concentration: 1.0
type: Species
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57538
constant: false
is: C01103
name: Orotidine 5'-phosphate
boundary condition: false

metaM 2oxoadp m
boundary condition: false
is: SBO:0000247
is: CHEBI:57499
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
initial concentration: 1.0
is: HMDB00225
constant: false
initial amount: NaN
type: Species
name: 2-oxoadipate(2-)
has only substance units: false

metaR PIPLC
fast: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
name: phosphatidylinositol phospholipase C

metaM ca2 c
constant: false
name: calcium(2+)
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00464
is: CHEBI:29108
type: Species
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN

metaM hpdca e
is: SBO:0000247
type: Species
is: HMDB02259
is: CHEBI:32366
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
name: margarate
boundary condition: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1

metaR O2tm
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
fast: false
product: MODEL1310110038#
name: O2 transport (diffusion)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
reactant: MODEL1310110038#
is described by: ECO:0000000

metaM nrpphrsf c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: HMDB02062
initial amount: NaN
name: Sulfate derivative of norepinephrine
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b47e973c_7d8b_4e30_8002_791253a8d1c4
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6648
is: P04179
has only substance units: false
name: SOD2
constant: false
initial amount: NaN

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM 5tedtricoa m
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5,8,11-tetradecatrienoylcoa
type: Species
is: HMDB02288
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_02ad2458_2ac2_4650_833f_75f8f9cb6f64
constant: false
initial concentration: NaN
type: Species
is: Q9Y5B8
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:29922
boundary condition: true
name: NME7

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: leukotriene E4(1-)
has only substance units: false
initial concentration: 1.0
is: CHEBI:57462
initial amount: NaN

metaR SQLEr
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is described by: ECO:0000134
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.132
reversible: false
fast: false
kinetic law: MODEL1310110038#

metaR r1527
fast: false
product: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_66593cfd_8e39_4c27_b9ae_997f56e69a12
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1339
boundary condition: true
is: Q02221
constant: false
name: COX6A2

metaR S6T17g
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
product: MODEL1310110038#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR PRPNCOAHYDm
reversible: false
product: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is: SBO:0000176
name: Propenoyl-CoA hydrolase (m)
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110038#_28203a62_d6e6_44c8_a9ea_b3183d90cc08
initial amount: NaN
is encoded by: hsa:514
initial concentration: NaN
constant: false
is: SBO:0000252
name: ATP5E
has only substance units: false
type: Species
boundary condition: true

metaM 3mlda c
name: 3-Methylimidazoleacetic acid
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: C05828
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB02820
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: http://identifiers.org/pubchem.compound/8122

http://identifiers.org/biomodels.db/MODEL1310110038#_47b847a8_82ab_4cec_bcaf_ee08dfe9704a
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:411
is: A8K4A0
initial concentration: NaN
name: ARSB

metaM 4nphsf c
boundary condition: false
is: SBO:0000247
name: 4-Nitrophenyl sulfate
is: HMDB06492
is: CHEBI:35422
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR biomass reaction
name: biomass_reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1cef3298_fac3_4ab1_988b_61023cac88b2
constant: false
has only substance units: false
type: Species
boundary condition: true
name: _R06874_1_r
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:R06874
initial concentration: NaN

metaM crn e
initial concentration: 1.0
is: CHEBI:16347
type: Species
has only substance units: false
is: C00318
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
is: HMDB00062
name: L-Carnitine
boundary condition: false
constant: false

metaM thmpp m
name: Thiamine diphosphate
is: CHEBI:45931
has only substance units: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: HMDB01372
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM 3pg m
type: Species
is: CHEBI:58272
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: SBO:0000247
is: HMDB00807
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
constant: false
initial concentration: 1.0

metaR GHMT2rm
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
reactant: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110038#_1fa34b6b_3dee_4f1b_85ee_8ab88525eee9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AI934540
constant: false
has only substance units: false
name: _AI934540_1_c

metaM hpdca c
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: margarate
is: CHEBI:32366
is: HMDB02259
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
has only substance units: false
initial concentration: 1.0
type: Species

metaR CYTK2n
is described by: ECO:0000269
name: cytidylate kinase (dCMP),nuclear
fast: false
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d9b2509b_eb9f_4979_a62d_34d5ed5ac2d9
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: _NOS2A_1_c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NOS2A
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_0def8042_3c08_4131_8e73_1d21bcac4593
type: Species
name: IDH2
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: P48735
initial concentration: NaN
is encoded by: hsa:3418

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM dcsptn1coa c
boundary condition: false
is: C16173
has only substance units: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
constant: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial concentration: 1.0

metaR r0377
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
reversible: false
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_e14f4c8e_331d_4d5a_aa97_d73f7a9f709b
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P51648
has only substance units: false
type: Species
name: ALDH3A2
constant: false
initial amount: NaN
is encoded by: hsa:224

http://identifiers.org/biomodels.db/MODEL1310110038#_5957a0fc_a0f2_4455_89d6_bb6e7bcf770b
type: Species
is: P33908
initial amount: NaN
boundary condition: true
is encoded by: hsa:4121
is: SBO:0000252
initial concentration: NaN
name: MAN1A1
has only substance units: false
constant: false

metaM pcrn c
is: SBO:0000247
initial amount: NaN
name: propionyl-carnitine
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
type: Species
is: HMDB00824
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
initial concentration: 1.0
constant: false

metaR r0494
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176

metaR SUCRe
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.10
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
name: sucrose hydrolyzing enxyme, extracellular
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269

metaM cs e deg6 l
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
is: CHEBI:16953
is: HMDB00812
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_126e5b62_8fdd_434a_b392_b7530660e13b
initial amount: NaN
name: EHHADH
is encoded by: hsa:1962
is: Q9NY65
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaM pristcoa x
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:51341

metaM CE2432 m
type: Species
initial amount: NaN
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432

metaR FAOXC17C15m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR AHEXASE2ly
is: SBO:0000176
fast: false
modifier: MODEL1310110038#
reversible: false
product: MODEL1310110038#
reactant: MODEL1310110038#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaM 3mb2coa m
initial amount: NaN
name: 3-methylbut-2-enoyl-CoA(4-)
is: SBO:0000247
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57344
is: HMDB01493

metaR O2tp
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, peroxisomal
is: SBO:0000185
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR S6TASE22ly
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
reversible: true

metaM dece3coa m
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
name: 3-decenoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_2e6ea046_2c45_48ab_9879_fe0ab8d2ced5
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: MBOAT2
is encoded by: hsa:129642
is: Q6ZWT7

metaM phytcoa x
type: Species
has only substance units: false
name: phytanoyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57391
initial amount: NaN
boundary condition: false
is: HMDB01359
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
constant: false

metaR C102CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM pac c
boundary condition: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
initial concentration: 1.0
has only substance units: false
is: CHEBI:18401
name: phenylacetate
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR SUCCOAPET
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_706acbe8_538d_47b7_bfe8_daa1f42653b2
constant: false
has only substance units: false
is: Q9Y3Y1
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:65010
initial amount: NaN
name: SLC26A6

metaM ksi g
has only substance units: false
is: HMDB01644
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17140
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
name: keratan sulfate I

metaR TETDECE1CRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaM f1a l
constant: false
initial concentration: 1.0
name: F1alpha
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17151
initial amount: NaN

metaM so4 c
initial amount: NaN
is: HMDB01448
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
name: sulfate
is: CHEBI:16189
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_2380b924_785c_477c_a9f0_f24b26b276d9
is: Q9BTY2
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: FUCA2
is encoded by: hsa:2519
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR DUDPtn
type: Reaction
name: dUDP nuclear transport
reversible: true
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000

metaR TIGCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM nadph c
is: CHEBI:57783
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
has only substance units: false
boundary condition: false
type: Species
constant: false
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

http://identifiers.org/biomodels.db/MODEL1310110038#_007949f7_7c59_415d_8562_a9d18dc4c589
is encoded by: hsa:1340
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: P14854
type: Species
name: COX6B1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_cdd717b2_0103_48c8_b262_ce11d93c9519
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:10327
name: AKR1A1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_033e4d79_e5a0_4b86_9238_07c1ba0194d0
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:AU149534
initial concentration: NaN
name: _AU149534_1_e
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_3f400197_4f25_4747_b9f6_0368963f825e
has only substance units: false
is: P35754
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: GLRX
is encoded by: hsa:2745
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_c6bfc111_40e8_40fb_aff6_2429832449d2
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA664770
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: _AA664770_1_m

metaM undcoa m
boundary condition: false
is: HMDB13114
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
initial concentration: 1.0
name: undecanoylcoa
constant: false
type: Species

metaR It
is described by: ECO:0000269
reversible: true
name: Iodide uniport
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaM gar c
boundary condition: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: HMDB02022
name: N1-(5-Phospho-D-ribosyl)glycinamide
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C03838
is: CHEBI:58457

metaR r0497
fast: false
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
product: MODEL1310110038#
reversible: true

metaR EX 4mptnl LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-methylpentanal Exchange
type: Reaction

metaM hdcecrn c
type: Species
is: HMDB00222
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Hexadecenoyl carnitine
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
constant: false
is: SBO:0000247

metaR FUMAC
modifier: MODEL1310110038#
name: fumarylacetoacetase
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.7.1.2
is: SBO:0000176
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM 3mldz c
initial amount: NaN
has only substance units: false
is: CHEBI:28104
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
name: 1-methylimidazole-4-acetaldehyde
is: HMDB04181
is: SBO:0000247

metaR VALtec
fast: false
reversible: true
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-valine transport via diffusion (extracellular to cytosol)

metaM 3tdcrn e
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H41NO5 CHARGE: 0
type: Species
constant: false
name: 3-hydroxy-tetradecanoyl carnitine
initial concentration: 1.0
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110038#_94851fa0_a4c4_4f24_962d_592841664ca4
constant: false
name: ALDH2
is: SBO:0000252
is encoded by: hsa:217
has only substance units: false
is: P05091
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_bbd7c570_ee1f_423a_a38a_e312aa675593
has only substance units: false
is: P23921
is: SBO:0000252
is encoded by: hsa:6240
name: RRM1
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_693b9380_479d_4e40_a07c_40bbc0cbc45d
boundary condition: true
is encoded by: hsa:4704
initial amount: NaN
name: NDUFA9
type: Species
initial concentration: NaN
is: Q16795
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_d663f276_5f08_4b81_b725_5a99b96c875d
constant: false
is: Q53YE7
initial concentration: NaN
name: MAOA
is encoded by: hsa:4128
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM arachd l
is: HMDB01043
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:32395
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
type: Species

metaM sebcoa c
initial amount: NaN
initial concentration: 1.0
name: sebacoylcoa
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: SBO:0000247
is: HMDB13325

metaR r1544
is described by: ECO:0000000
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110038#
reversible: true
is: SBO:0000185

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR r0480
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_672ff83a_c95d_49bd_acdd_c0f5c44fd77f
type: Species
name: CPT1B
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q92523
is encoded by: hsa:1375
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_6441f62b_dd78_4c1d_be28_cd623582dbf0
boundary condition: true
is encoded by: hsa:3425
is: SBO:0000252
constant: false
is: P35475
has only substance units: false
initial concentration: NaN
type: Species
name: IDUA
initial amount: NaN

metaM ribflv e
is: CHEBI:3554
type: Species
name: Riboflavin
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00244
is: SBO:0000247
is: C00255
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial amount: NaN
boundary condition: false

metaM ala D c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:15570
is: HMDB01310
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
name: D-alanine

metaR RE2974C
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110038#
type: Reaction
reversible: true
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.149
modifier: MODEL1310110038#
name: RE2974
is: SBO:0000176

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR THMP
is: SBO:0000176
name: thiamin phosphatase
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
product: MODEL1310110038#
reversible: false

metaM CE2422 m
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
boundary condition: false
initial amount: NaN
is: HMDB11123
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial concentration: 1.0
type: Species

metaM so4 l
is: HMDB01448
name: sulfate
is: CHEBI:16189
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM 3tdcrn c
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H41NO5 CHARGE: 0
is: HMDB02014
is: SBO:0000247
type: Species
name: 3-hydroxy-tetradecanoyl carnitine
constant: false
initial concentration: 1.0
has only substance units: false

metaR NACHEXA12ly
is described by: ECO:0000000
modifier: MODEL1310110038#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52

metaM 5HPET r
boundary condition: false
name: 5(S)-HPETE(1-)
initial concentration: 1.0
type: Species
is: CHEBI:57450
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
constant: false
is: SBO:0000247
is: HMDB01193
initial amount: NaN

metaR ACOX22x
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
is version of: http://identifiers.org/ec-code/1.17.99.3
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000304
reactant: MODEL1310110038#
is: SBO:0000176
name: acyl-Coenzyme A oxidase 2, branched chain
fast: false
type: Reaction
reversible: false

metaR ADRNCRNt
modifier: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
fast: false
reactant: MODEL1310110038#
name: transport into the mitochondria (carnitine)
reversible: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_bf4804cc_60db_46f2_aa94_7886976058a2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5295
boundary condition: true
is: E7EX19
name: PIK3R1
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

metaR P450SCC1m
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is described by: ECO:0000134
fast: false
name: cholesterol monooxygenase
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reversible: true

metaR RE3627M
reversible: true
product: MODEL1310110038#
modifier: MODEL1310110038#
name: RE3627
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaM 5fthf m
is: SBO:0000247
is: HMDB01562
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57457
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
initial amount: NaN
type: Species
initial concentration: 1.0
name: 5-formyltetrahydrofolate(2-)

metaR SUCD1m
type: Reaction
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000134
reversible: true
fast: false

metaM ptdcacoa c
type: Species
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06499
constant: false
name: pentadecanoyl Coenzyme A
boundary condition: false
initial concentration: 1.0

metaR r1433
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000000

metaR r1546
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110038#

metaM so4 m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01448
name: sulfate

metaM ala D e
initial concentration: 1.0
boundary condition: false
is: CHEBI:15570
is: HMDB01310
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine

metaM 3hpp m
constant: false
initial concentration: 1.0
name: 3-hydroxypropionate
type: Species
is: HMDB00700
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
boundary condition: false
is: CHEBI:16510
has only substance units: false
is: SBO:0000247

metaR RE3269C
modifier: MODEL1310110038#
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
name: RE3269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.48

metaM ribflv c
is: C00255
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Riboflavin
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
type: Species
is: HMDB00244

http://identifiers.org/biomodels.db/MODEL1310110038#_1d40039d_88f0_4126_940f_8fab285fb88c
constant: false
type: Species
has only substance units: false
name: SUCLG2
boundary condition: true
is: SBO:0000252
is: Q96I99
initial amount: NaN
is encoded by: hsa:8801
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_094edd21_dfd7_48a6_b9a4_cfab14571b5e
is: Q9HBH5
boundary condition: true
is encoded by: hsa:57665
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: RDH14
type: Species
has only substance units: false

metaR DOLDPP Uer
is version of: http://identifiers.org/ec-code/3.6.1.43
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
reversible: false
is: SBO:0000176

metaR r1547
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR RE2079R
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: RE2079
fast: false
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

metaM fuc1p L c
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28319
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: L-Fucose 1-phosphate
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265

metaR r0384
product: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2

metaR ACETONEt2
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
name: acetone transport via proton symport
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_67df8386_5055_483d_9c8f_f4246605e12d
is: Q9H5J4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79071
type: Species
constant: false
name: ELOVL6
boundary condition: true

metaR FTCD
name: formimidoyltransferase cyclodeaminase
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000134
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.1.2.5

metaR FAOXC102C81x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaM 3dpdhb me m
constant: false
is: SBO:0000247
type: Species
is: CHEBI:50776
initial amount: NaN
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate
notes: FORMULA: C58H87O4 CHARGE: -1 INCHI: InChI=1S/C58H88O4/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58(60)61)43-56(62-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43,59H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3,(H,60,61)/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM dodecanac c
is: SBO:0000247
name: Dodecanedioic acid
type: Species
boundary condition: false
notes: FORMULA: C12H20O4 CHARGE: -2
is: HMDB00623
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaM ksii core2 pre7 g
boundary condition: false
is: C00130
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 7
initial amount: NaN
is: HMDB00175
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: SBO:0000247
is: CHEBI:58053

metaM pro D c
initial concentration: 1.0
boundary condition: false
name: D-proline
is: CHEBI:16313
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411

metaM m4masn g
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
is: SBO:0000247
initial amount: NaN
is: C05881
initial concentration: 1.0
notes: FORMULA: C46H77N2O35X CHARGE: 0
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_bd42121d_0078_4010_ac9d_c130aa4c6fb2
is: P07451
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:761
name: CA3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a5185679_f9a4_426d_b653_d670df1ecd92
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:7296
name: TXNRD1
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR FCOAH
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
name: formyl coa hydrolase

http://identifiers.org/biomodels.db/MODEL1310110038#_2256334e_1141_4af5_b6dc_b327267c67d8
type: Species
is encoded by: hsa:5277
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PIGA
constant: false
is: B3KUV7

metaR RETFA
type: Reaction
product: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: retinol acyltransferase
fast: false
reactant: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR FAOXC12DCx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM hdd2coa c
initial concentration: 1.0
is: C05272
name: trans-Hexadec-2-enoyl-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
type: Species
is: CHEBI:61526
has only substance units: false
initial amount: NaN
is: HMDB03945
boundary condition: false

metaM ppcoa m
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB01275
name: Propanoyl-CoA
is: C00100
is: CHEBI:57392
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
type: Species
boundary condition: false

metaM itacon m
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB02092
is: SBO:0000247
type: Species
name: itaconate(2-)
constant: false
is: CHEBI:17240

metaM HC01609 e
initial concentration: 1.0
type: Species
is: CHEBI:28766
name: UroporphyrinogenI
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM gullac c
type: Species
boundary condition: false
initial amount: NaN
is: HMDB03466
is: CHEBI:17587
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: L-gulono-1,4-lactone

http://identifiers.org/biomodels.db/MODEL1310110038#_d1166bff_79a9_4b82_a9cd_698eb8193150
constant: false
boundary condition: true
is: P38117
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2109
has only substance units: false
name: ETFB
is: SBO:0000252

metaR r1548
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_4c22f48a_4a9e_471a_975d_7b0780aebeab
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q92604
initial amount: NaN
type: Species
name: LPGAT1
is encoded by: hsa:9926
initial concentration: NaN

metaR C30CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaR DNDPt36m
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dCDP antiport
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
reversible: false
is described by: ECO:0000269
is: SBO:0000185

metaM HC01409 m
constant: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
has only substance units: false
name: Hexanoyl-CoA
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM eicostetcoa m
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
name: eicosatetranoyl coenzyme A
initial amount: NaN
boundary condition: false
constant: false
is: C16164
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_a1554a9c_e2fe_4b7c_be4e_2710aa5b7375
initial concentration: NaN
is: P04843
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: RPN1
is encoded by: hsa:6184
initial amount: NaN
boundary condition: true

metaM acac c
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
is: HMDB00060
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_f3a2cf70_9cd0_4451_b68a_386267f99d8c
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:126
name: ADH1C
is: P00326
type: Species
has only substance units: false
is: SBO:0000252

metaM arachd r
constant: false
boundary condition: false
name: arachidonate
has only substance units: false
initial amount: NaN
is: CHEBI:32395
initial concentration: 1.0
is: SBO:0000247
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
type: Species

metaR CHLtm
name: choline transport via diffusion (cytosol to mitochondria)
reactant: MODEL1310110038#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110038#

metaR r1549
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_40a94930_e61e_404e_a028_aae152dcdde7
has only substance units: false
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:BC005314
name: _BC005314_1_x
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
type: Species
constant: false

metaR PEPCKm
name: Phosphoenolpyruvate carboxykinase (GTP)
fast: false
product: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.1.1.32
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_0e017e49_a328_4a2a_be83_b2fd1808391d
initial amount: NaN
type: Species
name: PIGX:PIGM
is: SBO:0000297
boundary condition: true
has part: Q8TBF5
is encoded by: hsa:93183
constant: false
is encoded by: hsa:54965
initial concentration: NaN
has only substance units: false
has part: Q9H3S5

metaR G14T18g
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaM s2l2n2m2m l
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06529
is: CHEBI:50570
boundary condition: false
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false
constant: false
name: de-Fuc form of PA6 (w/o peptide linkage)

metaM ksii core2 deg1 l
name: keratan sulfate II (core 2-linked), degradation product 1
constant: false
is: CHEBI:57737
has only substance units: false
is: HMDB00868
boundary condition: false
type: Species
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r0381
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
type: Reaction
reactant: MODEL1310110038#
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000

metaR FADDPle
name: FAD diphosphatase
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.1

metaM 3oddcoa x
is: HMDB03937
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:27868
name: 3-Oxododecanoyl-CoA
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
constant: false

metaM betald c
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
boundary condition: false
is: CHEBI:15710
name: betaine aldehyde
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_7f95c69a_3cac_4449_8ae1_59b0cec1dee9
constant: false
name: NDUFB6
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q5VYT2
has only substance units: false
is encoded by: hsa:4712
type: Species
initial concentration: NaN

metaR UAGALDP
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110038#
reversible: false
name: UDP-N-acetylgalactosamine diphosphorylase
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_7bb54893_5668_46ea_80df_8095bca5decb
is encoded by: hsa:23556
is: O95427
initial amount: NaN
type: Species
name: PIGN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM acac e
has only substance units: false
boundary condition: false
is: CHEBI:13705
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
type: Species
name: acetoacetate
constant: false
is: SBO:0000247
is: HMDB00060

metaR FAOXC200180m
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110038#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaM galside hs g
boundary condition: false
is: CHEBI:12947
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
type: Species
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_25d56717_493b_4d7d_9787_50fe0c985864
has only substance units: false
type: Species
name: SYNJ1
constant: false
is encoded by: hsa:8867
boundary condition: true
initial concentration: NaN
is: O43426
initial amount: NaN
is: SBO:0000252

metaR ALADGLYexR
product: MODEL1310110038#
is described by: ECO:0000304
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: D-alanine/glycine reversible exchange
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185

metaM dopasf c
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:37946
initial concentration: 1.0
is: HMDB06275
is: SBO:0000247
name: dopamine 3-O-sulfate
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_ecfa207d_5163_4026_9312_ebda01e26d20
is encoded by: hsa:2987
initial concentration: NaN
is: Q16774
boundary condition: true
name: GUK1
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR EICOSTETCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110038#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR BILIRUBt2
type: Reaction
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: bilirubin transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true

metaM udpglcur c
type: Species
has only substance units: false
is: C00167
is: HMDB00935
is: SBO:0000247
name: UDP-D-glucuronate
initial amount: NaN
is: CHEBI:58052
boundary condition: false
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
constant: false

metaM arachd e
name: arachidonate
is: CHEBI:32395
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: HMDB01043

metaM c12dccoa x
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB03712
name: dodecanedioylcoa

metaM HC00319 m
initial concentration: 1.0
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: SBO:0000247
is: CHEBI:30794
has only substance units: false
boundary condition: false
constant: false
name: Malonate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_f0e4935e_589e_492c_b6b8_32b5a745a383
is encoded by: hsa:5959
boundary condition: true
has only substance units: false
is: Q92781
name: RDH5
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaM 4nph e
constant: false
name: 4-nitrophenolate
is: CHEBI:57917
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
initial amount: NaN
type: Species
is: SBO:0000247

metaR ACCOAgt
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
name: acetyl-coa transport
product: MODEL1310110038#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110038#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#

metaM agm m
boundary condition: false
initial concentration: 1.0
name: agmatinium(2+)
notes: FORMULA: C5H16N4 CHARGE: 2 INCHI: InChI=1S/C5H14N4/c6-3-1-2-4-9-5(7)8/h1-4,6H2,(H4,7,8,9)/p+2 HEPATONET_1.0_ABBREVIATION: HC00171 EHMN_ABBREVIATION: C00179
has only substance units: false
is: CHEBI:58145
constant: false
is: SBO:0000247
type: Species
is: HMDB01432
initial amount: NaN

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_452ab982_c0bc_4ff2_9de0_d3c0fbd2ca55
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3284
name: HSD3B2
type: Species
boundary condition: true
is: P26439

metaR 1PPDCRp
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176
product: MODEL1310110038#
fast: false

metaR EX 34hpp
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_1d6e6526_c445_4d55_86e5_2cd799923f76
is: SBO:0000252
constant: false
is: B3KXY9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3098
name: HK1
boundary condition: true
initial amount: NaN
type: Species

metaR r2067
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false

metaM fadh2 c
is: CHEBI:58307
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01197
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: SBO:0000247
name: FADH2(2-)

metaM HC00900 c
constant: false
type: Species
name: Methylmalonate
is: CHEBI:30860
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM dopasf e
type: Species
has only substance units: false
constant: false
is: CHEBI:37946
is: SBO:0000247
boundary condition: false
is: HMDB06275
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate

metaR C12DCTD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM ksi deg4 l
is: SBO:0000247
name: keratan sulfate I, degradation product 4
is: CHEBI:57737
boundary condition: false
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
constant: false
is: HMDB00868
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_2b7483c6_8049_4e2c_9e52_e03bf2b7b5f8
has only substance units: false
is: SBO:0000252
is: Q9NTN3
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:23169
constant: false
name: SLC35D1

http://identifiers.org/biomodels.db/MODEL1310110038#_b426c005_fb37_451f_82f6_45017bfd299c
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: GART
is encoded by: hsa:2618
type: Species
is: Q59HH3
has only substance units: false
initial concentration: NaN

metaR IVCOAACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

metaR C161CRNt
type: Reaction
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
reversible: false
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: C161 transport into the mitochondria
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is described by: ECO:0000000

metaR GGLUCT
modifier: MODEL1310110038#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.2.4
is described by: ECO:0000269
reversible: false
name: gamma-glutamylcyclotransferase
product: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
fast: false
reactant: MODEL1310110038#

metaR r2066
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110038#

metaM HC00361 c
initial concentration: 1.0
name: sedoheptulose 1,7-bisphosphate(4-)
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: CHEBI:58335
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_b459a121_4c23_4ee2_ad3f_1f619f1f6114
is encoded by: hsa:2530
is: G3V5N0
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: FUT8

metaM 4nph c
is: CHEBI:57917
name: 4-nitrophenolate
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
constant: false

metaM eitetcoa m
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 5,8,11,14-eicosatetraenoylcoa
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaR PAIL45P HStn
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185

metaR EICOSTETCPT2
reversible: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
name: carnitine transferase

metaM 2docohexecoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,7,10,13,16,19-docosahexenoylcoa
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
type: Species

metaR MCCCrm
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: methylcrotonoyl-CoA carboxylase, mitochondrial
kinetic law: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.4.1.4
modifier: MODEL1310110038#

metaR C162ACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR DNDPt9m
name: dADP transport via dTDP antiport
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110038#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
reversible: false
product: MODEL1310110038#

metaR r1648
is described by: ECO:0000000
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110038#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0095ccd2_4a60_4a9f_ba66_7365be4ebe20
type: Species
has only substance units: false
is: SBO:0000252
name: _BE966236_1_c
is encoded by: hsa:BE966236
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r0908
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
name: Postulated transport reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
kinetic law: MODEL1310110038#

metaM ade e
is: HMDB00034
constant: false
initial amount: NaN
name: adenine
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial concentration: 1.0
is: CHEBI:16708
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaR r1434
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_16207df0_9c80_41a3_bba7_0714db218ada
is encoded by: hsa:29922
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: NME7

metaR r0590
type: Reaction
reactant: MODEL1310110038#
reversible: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#

metaM lnlncgcrn c
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
initial concentration: 1.0
type: Species
name: gamma-linolenyl carnitine
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB06318
constant: false

metaR Q10H2e
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
reversible: true
name: transport of ubiquinol into lymph
is described by: ECO:0000134
is: SBO:0000185

metaM galside hs c
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
initial amount: NaN
is: CHEBI:12947

metaM gd3 hs g
is: SBO:0000247
name: GD3
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial concentration: 1.0
is: CHEBI:28424
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaR THRGLNexR
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
fast: false
reactant: MODEL1310110038#
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
modifier: MODEL1310110038#
product: MODEL1310110038#

metaM txa2 r
has only substance units: false
is: HMDB01452
type: Species
name: thromboxane A2(1-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
constant: false
boundary condition: false
initial concentration: 1.0

metaR DOLP Uter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110038#
reversible: false
name: dolichol phosphate flippase (uterus)
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_78248472_b66d_4c19_8b5f_5991b44635da
is encoded by: hsa:4967
is: Q02218
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: OGDH
boundary condition: true
is: SBO:0000252

metaR r1649
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM icit c
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
is: C00311
has only substance units: false
is: CHEBI:16087
is: HMDB00193
name: Isocitrate

metaM CE5786 e
initial amount: NaN
has only substance units: false
type: Species
name: kinetensin
constant: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: CHEBI:27485
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB02710

metaR r0907
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
name: Active transport

metaR MMTSADm
reversible: false
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
type: Reaction

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r1435
is described by: ECO:0000000
product: MODEL1310110038#
reversible: false
name: Transport reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_f3b27d67_af7e_44b2_8515_d6a01e3a7f54
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI291895
name: _AI291895_1_c

metaM arachcrn m
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
name: arachidyl carnitine
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06460

http://identifiers.org/biomodels.db/MODEL1310110038#_302a2917_288d_4a63_ae19_fa654c4438de
is encoded by: hsa:55229
is: Q9NVE7
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: PANK4
is: SBO:0000252
boundary condition: true

metaR r1540
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
reversible: false
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_794dee39_60bd_43bc_ac13_56c9022764cd
has only substance units: false
name: SLC3A2
is: P08195
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6520
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_c9e79d96_a5ff_4bde_9056_e4aee80fd81a
is encoded by: hsa:522
has only substance units: false
constant: false
has part: Q6IB54
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110038#_58e84e87_63ee_4431_a88e_09279d141704
is: P43353
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:221
type: Species
is: SBO:0000252
name: ALDH3B1

http://identifiers.org/biomodels.db/MODEL1310110038#_7deb73b9_66db_4a5a_ae09_e93f17579f54
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6817
constant: false
initial concentration: NaN
name: SULT1A1
has only substance units: false
type: Species
initial amount: NaN

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_68f440d4_0f06_4bc1_a023_c006dd382744
boundary condition: true
is encoded by: hsa:642502
type: Species
name: _642502_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR AMACR2p
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
modifier: MODEL1310110038#
product: MODEL1310110038#
name: alpha-methylacyl-CoA racemase (reductase)
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/5.1.99.4

http://identifiers.org/biomodels.db/MODEL1310110038#_c8be538d_e260_45e0_8e7b_8d0144276864
is: SBO:0000252
is: P05187
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: ALPP
constant: false
initial concentration: NaN
is encoded by: hsa:250

metaR UMPK5n
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
name: UMP kinase (dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269

metaM occoa x
boundary condition: false
type: Species
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
constant: false
is: CHEBI:57386
initial concentration: 1.0
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
is: HMDB01070
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_addd76c1_1b8e_4105_ad52_528b0e9c5f79
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:954
initial amount: NaN
initial concentration: NaN
is: Q5SPY7
constant: false
has only substance units: false
name: ENTPD2

metaR CLHCO3tex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
name: chloride transport via bicarbonate countertransport (2:1)
reversible: false
kinetic law: MODEL1310110038#
is described by: ECO:0000304

metaM galside hs e
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaM sphs1p r
is: CHEBI:60119
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_cd2b973a_8b16_4094_b003_0d712dc38fd4
name: MYO5B
boundary condition: true
initial amount: NaN
is encoded by: hsa:4645
is: SBO:0000252
constant: false
type: Species
is: Q9H6Y6
has only substance units: false
initial concentration: NaN

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR HAS1
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
reversible: false
is: SBO:0000185
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269

metaR r0909
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110038#
name: Transport reaction
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_586c5b9f_0119_4fa7_b6f3_8e632b114d3d
boundary condition: true
name: MTMR3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8897
has only substance units: false
constant: false

metaM gpail hs c
is: CHEBI:17049
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

metaM c6crn x
has only substance units: false
name: hexanoyl carnitine
constant: false
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaR HAS2
is: SBO:0000185
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
product: MODEL1310110038#
fast: false
is described by: ECO:0000269
reversible: false

metaM ppcoa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57392
has only substance units: false
constant: false
is: C00100
name: Propanoyl-CoA
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species

metaM docohexcoa x
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: 2,4,7,10,13,16-docosahexenoylcoa
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_6eecaae8_34de_48e0_b2d0_3a3270ce8e7c
constant: false
is: SBO:0000252
name: IK
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: Q13123
is encoded by: hsa:3550
boundary condition: true

metaR GLYt2r
kinetic law: MODEL1310110038#
is described by: ECO:0000304
name: glycine reversible transport via proton symport
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#

metaM gln L m
is: HMDB00641
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:18050
is: SBO:0000247
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
name: L-glutamine

metaM CE2433 m
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
has only substance units: false
is: SBO:0000247
is: CHEBI:57795

metaR r1657
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaR SERCYSNaEx
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000269
type: Reaction
name: L-serine/L-cysteine Na-dependent exchange (Ser-L in)
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR AG13T6g
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110038#

metaM coa x
has only substance units: false
is: HMDB01423
name: Coenzyme A
is: CHEBI:57287
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
is: C00010
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR UDPG4E
name: UDPglucose 4-epimerase
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
is: SBO:0000176
product: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_01e9f799_032b_456f_9332_712e4e774b57
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: _AI378339_1_m
is encoded by: hsa:AI378339

metaM CE5586 c
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:58732

http://identifiers.org/biomodels.db/MODEL1310110038#_01f2abd1_cbf7_4de8_9172_d511ae154a73
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
name: CRAT
is encoded by: hsa:1384
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_da7b29be_299c_4052_81c6_df16ef0f9dec
type: Species
is encoded by: hsa:1621
name: DBH
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P09172
initial concentration: NaN
initial amount: NaN
constant: false

metaR GULNDer
reversible: true
name: gulonate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110038#
fast: false
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reactant: MODEL1310110038#
is described by: ECO:0000000

metaM ksii core2 pre4 g
has only substance units: false
is: CHEBI:58053
initial concentration: 1.0
is: C00130
is: SBO:0000247
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: HMDB00175
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 4
type: Species
constant: false
boundary condition: false

metaR FADtx
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: FAD transporter, peroxisomal

metaR DOLPMT3 Uer
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.260
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR r0594
type: Reaction
product: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reactant: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_63983d45_d2e5_4c4f_8c1e_931de5835079
constant: false
is encoded by: hsa:57282
type: Species
boundary condition: true
name: SLC4A10
initial amount: NaN
has only substance units: false
is: B7Z1R0
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_fa23fb07_8143_4b46_a054_129c9d8cc799
name: LYZL1
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84569
is: Q6UWQ5
type: Species
constant: false

metaR r1656
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
fast: false
is: SBO:0000185

metaM gtp e
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
is: HMDB01273
constant: false
initial amount: NaN
is: CHEBI:37565
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_32307026_df41_4104_ba70_953121ec4baf
has only substance units: false
constant: false
type: Species
name: PIP4K2C
initial concentration: NaN
is encoded by: hsa:79837
is: B3KQV3
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaM acac m
is: SBO:0000247
name: acetoacetate
is: HMDB00060
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM ppcoa x
is: C00100
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01275
is: CHEBI:57392
has only substance units: false
type: Species
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
name: Propanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110038#_b1d93885_76e9_4ed2_8f3a_c31a8e7a13b1
initial amount: NaN
constant: false
name: NT5C2
type: Species
is: SBO:0000252
is: P49902
boundary condition: true
initial concentration: NaN
is encoded by: hsa:22978
has only substance units: false

metaR M16NTg
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
is: SBO:0000176
reversible: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reactant: MODEL1310110038#
fast: false

metaM xu1p D c
initial amount: NaN
type: Species
name: D-Xylulose 1-phosphate
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: HMDB06534

metaR TXA2te
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
name: thromboxane A2 transport
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reversible: true

metaR FAOXC102C81m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_fd04a025_81d6_4953_b371_7bb869128849
is: SBO:0000252
name: GBA
boundary condition: true
is: B7Z6S1
constant: false
is encoded by: hsa:2629
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaM ksi pre26 g
constant: false
is: SBO:0000247
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
type: Species
initial concentration: 1.0
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 26
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
product: MODEL1310110038#
fast: false
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true

metaM hdd2coa m
boundary condition: false
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
is: C05272
constant: false
type: Species
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
is: HMDB03945
is: CHEBI:61526
initial concentration: 1.0

metaR r1659
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM xylt c
is: HMDB02917
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
name: xylitol
is: CHEBI:17151
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false

metaR DLNLCGCPT1
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110038#_79e1d0af_5589_44fb_b01a_0314cf461c88
is encoded by: hsa:1350
is: SBO:0000252
type: Species
name: COX7C
boundary condition: true
has only substance units: false
initial amount: NaN
is: P15954
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_ad9d6918_87d3_489d_a01a_9282ac955616
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: ACSL4
has only substance units: false
is encoded by: hsa:2182
initial concentration: NaN
is: Q5JWV8
constant: false

metaM dhcrm hs c
is: SBO:0000247
is: CHEBI:31488
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial concentration: 1.0
name: dihydroceramide
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_901a1ec7_f97e_4bdf_b5dd_6c2f5efd1eab
constant: false
initial concentration: NaN
is: SBO:0000252
name: AGPAT3
type: Species
initial amount: NaN
is encoded by: hsa:56894
has only substance units: false
boundary condition: true

metaR r0055
is version of: http://identifiers.org/ec-code/2.4.2.7
product: MODEL1310110038#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)

metaR r1658
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110038#
modifier: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_42c7a30f_99db_4383_a33a_84b0563f3edd
initial amount: NaN
has only substance units: false
is encoded by: hsa:10588
is: P49914
constant: false
name: MTHFS
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaM pristcoa c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: pristanoyl coa
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:51341

http://identifiers.org/biomodels.db/MODEL1310110038#_5c2f9965_87c7_4ba9_88d9_ad15e5973d9c
is: SBO:0000252
is encoded by: hsa:9154
initial amount: NaN
initial concentration: NaN
is: Q96PL7
has only substance units: false
boundary condition: true
name: SLC28A1
constant: false
type: Species

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM sphs1p e
constant: false
name: sphingosine 1-phosphate(1-)
boundary condition: false
initial amount: NaN
is: CHEBI:60119
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
is: HMDB00277
has only substance units: false
is: SBO:0000247

metaR RE2349C
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: RE2349
fast: false
reversible: true
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#
type: Reaction

metaM nac e
is: SBO:0000247
name: Nicotinate
boundary condition: false
is: HMDB01488
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
is: C00253
initial amount: NaN
is: CHEBI:0
has only substance units: false

metaR FAOXC16C16OHm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaR r1653
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d86147f6_6f21_4f29_b3c4_0de7c68b7067
boundary condition: true
name: IREB2
is: SBO:0000252
initial amount: NaN
constant: false
is: P48200
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3658

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM ksi pre34 g
type: Species
constant: false
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 34
initial concentration: 1.0
is: C00130
boundary condition: false
initial amount: NaN

metaR CTPtn
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110038#
reactant: MODEL1310110038#
name: CTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110038#

metaR DURItn
reversible: true
name: deoxyuridine transport in nucleus
kinetic law: MODEL1310110038#
type: Reaction
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185

metaM malttr e
is: CHEBI:27931
constant: false
has only substance units: false
is: HMDB01262
name: maltotriose
initial concentration: 1.0
type: Species
is: C01835
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
initial amount: NaN
boundary condition: false

metaR FAOXTC122m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization trans(C12:2)m
type: Reaction

metaR NDPK7n
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM sebcoa x
has only substance units: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
name: sebacoylcoa
type: Species
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: SBO:0000247
initial concentration: 1.0

metaM ksi pre6 g
type: Species
has only substance units: false
is: HMDB00175
initial amount: NaN
notes: FORMULA: C107H174N7O80SX CHARGE: -2
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 6
is: C00130
is: CHEBI:58053
is: SBO:0000247
constant: false

metaR DCSPTN1CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#

metaM xylt e
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: xylitol
is: HMDB02917
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151

http://identifiers.org/biomodels.db/MODEL1310110038#_07015e99_b12d_4f3e_b16c_185113493693
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: SLCO4A1
is: Q96BD0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:28231

metaR r1652
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_ca9bb579_db47_44af_8ae1_44402f9e03f6
has part: P54709
is encoded by: hsa:483
initial amount: NaN
name: ATP1A1:ATP1B3
boundary condition: true
has part: B7Z3U6
is encoded by: hsa:476
constant: false
initial concentration: NaN
is: SBO:0000297
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e75e9171_09f3_4f4f_a01d_664a2c21a5c0
constant: false
is encoded by: hsa:83733
initial concentration: NaN
boundary condition: true
type: Species
is: Q9H1K4
has only substance units: false
name: SLC25A18
initial amount: NaN
is: SBO:0000252

metaM ksi deg33 l
initial concentration: 1.0
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
name: keratan sulfate I, degradation product 33
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: HMDB00143

metaM icit m
is: HMDB00193
constant: false
initial amount: NaN
is: CHEBI:16087
is: SBO:0000247
boundary condition: false
is: C00311
has only substance units: false
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
name: Isocitrate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_b2d094d7_cf09_4f39_918a_36b5f2f40222
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:6487
boundary condition: true
constant: false
initial amount: NaN

metaM CE0693 m
name: 3-oxolaur-6-cis-enoyl-CoA
boundary condition: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
constant: false
is: CHEBI:28387
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB11123
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_fe0bf61c_2f5f_4b56_b41d_c39897d2b3f1
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:10400
has only substance units: false
is: SBO:0000252
name: PEMT

http://identifiers.org/biomodels.db/MODEL1310110038#_e0afd834_71ac_4e61_9691_cae32286746d
boundary condition: true
name: _AI769281_1_e
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI769281

metaM dgtp n
is: C00286
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01440
has only substance units: false
name: dGTP
is: CHEBI:16497
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR DCSPTN1CPT2
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110038#
type: Reaction
fast: false
is described by: ECO:0000000
name: carnitine transferase
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110038#

metaR BTNt4i
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reactant: MODEL1310110038#
fast: false
name: Biotin uptake (antiport)
product: MODEL1310110038#
type: Reaction

metaR r0276
is: SBO:0000176
kinetic law: MODEL1310110038#
fast: false
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110038#

metaR GNDer
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
name: phosphogluconate dehydrogenase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110038#_8d0eaaa4_743e_47ae_82c4_af6759f8a116
initial concentration: NaN
initial amount: NaN
constant: false
name: ACP2
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:53
type: Species
is: E9PCI1

metaM nac c
name: Nicotinate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01488
notes: FORMULA: C6H4NO2 CHARGE: -1
has only substance units: false
is: C00253
constant: false
is: CHEBI:0
initial amount: NaN

metaM coa r
constant: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
boundary condition: false
is: HMDB01423
initial concentration: 1.0
name: Coenzyme A
is: SBO:0000247
type: Species
is: C00010
has only substance units: false

metaR r1655
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#

metaM gtp m
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: C00044
name: GTP
is: HMDB01273
initial concentration: 1.0
type: Species
is: CHEBI:37565
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaM mpdol U c
initial amount: NaN
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
type: Species
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18396
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR DTTPtn
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_58bad0be_b605_47ac_a40f_21741d17cb9d
has only substance units: false
is encoded by: hsa:23439
boundary condition: true
constant: false
is: Q9UN42
type: Species
initial amount: NaN
initial concentration: NaN
name: ATP1B4
is: SBO:0000252

metaM Lkynr c
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16946
name: L-kynurenine
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: SBO:0000247
initial concentration: 1.0
is: HMDB00684
type: Species
initial amount: NaN

metaM 3odcoa m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
constant: false
initial amount: NaN
has only substance units: false
is: HMDB03939
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_e4729120_86ff_4f4f_b880_84134bae9878
type: Species
initial concentration: NaN
is encoded by: hsa:51227
initial amount: NaN
boundary condition: true
is: P57054
has only substance units: false
name: PIGP
constant: false
is: SBO:0000252

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is described by: ECO:0000269
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110038#
name: deoxyuridine phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110038#
modifier: MODEL1310110038#

metaM HC00319 c
initial concentration: 1.0
is: CHEBI:30794
constant: false
is: SBO:0000247
name: Malonate
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
has only substance units: false

metaR GALNTg
is: SBO:0000176
product: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.41
name: GalNAc transferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
type: Reaction

metaR IVCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR r1654
is: SBO:0000185
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR NACHEXA20ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
name: beta-N-acetylhexosaminidase A, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110038#

metaR r0051
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
product: MODEL1310110038#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reversible: true
is described by: ECO:0000000
type: Reaction

metaR r0596
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reversible: false
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_25395edc_fb63_4fe1_b4f7_b02fb8ac7d46
constant: false
is: SBO:0000252
name: CH25H
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: O95992
has only substance units: false
is encoded by: hsa:9023

metaR FAOXC16080m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
is described by: ECO:0000269

metaR GLUPRT
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.2.14
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110038#
name: glutamine phosphoribosyldiphosphate amidotransferase

http://identifiers.org/biomodels.db/MODEL1310110038#_7b24751c_4a3d_4b4e_91e1_c3065804881d
is: SBO:0000252
boundary condition: true
name: COX4I1
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1327
initial amount: NaN
is: P13073
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c3fba36c_8bfc_4447_88be_504f7940646b
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
is: Q6LEN6
name: CHAT
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_33e14f0e_423b_42cd_a191_2621f8d7d7f1
name: OGDH
boundary condition: true
is: B4E3E9
constant: false
initial amount: NaN
is encoded by: hsa:4967
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_f0c695df_cbfa_4d5e_8dc9_b1546846ad68
name: PIGB
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:9488
type: Species
is: Q92521
initial amount: NaN
boundary condition: true

metaR r0488
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
fast: false
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

http://identifiers.org/biomodels.db/MODEL1310110038#_2b5983f9_f070_44a0_9a3e_4f8248e7fe7d
type: Species
is encoded by: hsa:55808
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: ST6GALNAC1
is: Q9NSC7
boundary condition: true
initial concentration: NaN

metaM 3tetd7ecoa c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
is: HMDB05066
name: 3-hydroxy tetradecenoyl-7-coa
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_194e998b_675f_46f5_8a94_a7631c7bd713
is encoded by: hsa:482
has only substance units: false
name: ATP1A3:ATP1B2
has part: P14415
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
constant: false
boundary condition: true
type: Species

metaR FATP3t
is: SBO:0000185
product: MODEL1310110038#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110038#
name: fatty acid electroneutral transport
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110038#

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

metaR DASPO1p
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM
name: D-aspartate oxidase, peroxisomal
fast: false
reversible: false
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.4.3.1
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM icit x
initial concentration: 1.0
is: CHEBI:16087
boundary condition: false
has only substance units: false
name: isocitrate(3-)
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species
is: HMDB00193

metaR LNLNCAt
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110038#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_570308ba_63ce_4860_ad71_221973a806d8
is: P30566
is: SBO:0000252
name: ADSL
type: Species
is encoded by: hsa:158
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM hdcea c
has only substance units: false
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:32372
is: SBO:0000247
type: Species
is: HMDB03229
name: Hexadecenoate (n-C16:1)

metaR r1117
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reversible: true
name: Facilitated diffusion
is described by: ECO:0000000

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR C6COAt
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

metaM txa2 e
boundary condition: false
type: Species
is: HMDB01452
is: CHEBI:57445
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false
name: thromboxane A2(1-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_4455f9a1_c17e_42d9_b598_c1484e833334
is: Q9UBM7
initial amount: NaN
type: Species
is encoded by: hsa:1717
name: DHCR7
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: C06028
initial amount: NaN
type: Species
is: CHEBI:27969
boundary condition: false
has only substance units: false
name: Mesaconyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_488084ef_16a4_4983_a0d2_58dc424e8651
name: _AI761708_1_m
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI761708
type: Species

metaR NACHEXA19ly
modifier: MODEL1310110038#
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176

metaM gtp n
initial amount: NaN
constant: false
is: SBO:0000247
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
type: Species
has only substance units: false
is: HMDB01273
boundary condition: false
initial concentration: 1.0

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR r0388
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
type: Reaction
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
is: SBO:0000176
kinetic law: MODEL1310110038#

metaM ei11ecoa x
type: Species
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: 11-eicosenoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a5abe793_7267_427e_a13e_c86c3b31d65c
is: Q546H9
constant: false
is encoded by: hsa:7915
boundary condition: true
name: ALDH5A1
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR EX c51crn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_a67a3552_9e3a_4a71_9900_9103a6cc7b85
is: P78382
type: Species
is encoded by: hsa:10559
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC35A1
constant: false
initial concentration: NaN

metaR r1116
product: MODEL1310110038#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_4bdb3e62_d109_47e6_ade0_2b22d5fa583b
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: _BE042354_1_m
initial amount: NaN
is encoded by: hsa:BE042354

http://identifiers.org/biomodels.db/MODEL1310110038#_12039544_b7a9_4ae7_b2f9_92f3a00b8632
constant: false
name: SLC25A10
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1468
is: Q9UBX3
boundary condition: true

metaR ENGASEly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110038#
name: endo-beta-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110038#
reversible: false
fast: false

metaM 2dr1p c
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58576
has only substance units: false
is: HMDB01351
boundary condition: false
is: C00672
is: SBO:0000247

metaR C40CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM cs e deg3 l
is: SBO:0000247
is: HMDB00127
has only substance units: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
boundary condition: false
initial concentration: 1.0
is: CHEBI:15748
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
constant: false
initial amount: NaN
type: Species

metaR r1651
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110038#

metaM hdcea e
name: Hexadecenoate (n-C16:1)
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:32372
is: HMDB03229
type: Species

metaR ECOAH9m
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110038#

metaR MGSA2
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
reactant: MODEL1310110038#
product: MODEL1310110038#
name: methyglyoxylate synthase 2 (from g3p)
fast: false
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaR NACHORCTL3le
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: NACHORCTL3le
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_1b8d0465_d56e_45db_a76e_a72299a7442a
constant: false
boundary condition: true
is: A8K5J1
has only substance units: false
type: Species
initial amount: NaN
name: UMPS
initial concentration: NaN
is encoded by: hsa:7372
is: SBO:0000252

metaM 2mbcoa m
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
type: Species
is: CHEBI:57336
initial concentration: 1.0
is: HMDB01041
initial amount: NaN
is: SBO:0000247
constant: false

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaR DGULND
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
type: Reaction
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110038#

metaR r1650
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_04c733a2_1215_4c54_a4fa_e3202dea2371
name: _206_1_c
initial amount: NaN
is encoded by: hsa:206
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaM txa2 c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452
name: thromboxane A2(1-)
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:57445

metaM gullac r
name: L-gulono-1,4-lactone
is: CHEBI:17587
constant: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
has only substance units: false
is: HMDB03466
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR GLCAASE7ly
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaM dgtp e
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16497
name: dGTP
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110038#_e61f50a2_2fba_49a6_a070_e0e3cd8fdb75
initial concentration: NaN
boundary condition: true
is: A8MYF6
type: Species
name: MSMO1
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6307

metaR CYTK12n
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction

metaM ptdcacoa m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB06499
name: pentadecanoyl Coenzyme A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_66c43f02_5642_43f8_afc0_2b7c0389b486
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: P17752
boundary condition: true
name: TPH1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7166

http://identifiers.org/biomodels.db/MODEL1310110038#_0dd6ccc4_b125_4473_b61b_e77c67169b84
is: P00338
name: LDHA
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3939
initial concentration: NaN

metaR CYANt
reversible: true
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: Cyanide transport via diffusion (extracellular to cytosol)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_02165af3_d736_4d62_91b9_a7f0a6205956
is: Q96CA6
initial concentration: NaN
has only substance units: false
is encoded by: hsa:30
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: ACAA1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_2aaa32b6_1dfe_4999_b811_27e6f19f8600
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:10020
is: SBO:0000252
is: B7Z428
initial concentration: NaN
has only substance units: false
name: GNE

metaR C142CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaM sphs1p c
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00277
has only substance units: false
constant: false
is: CHEBI:60119

http://identifiers.org/biomodels.db/MODEL1310110038#_aa88b4cd_8678_4843_913f_5167d9792b77
type: Species
is: E9PH29
initial amount: NaN
has only substance units: false
name: PRDX3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10935
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_512a9d52_dae5_4444_bc67_4abffc8541c5
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: ACSL4
constant: false
is encoded by: hsa:2182
is: Q5JWV8

metaR DLNLCGCPT2
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
type: Reaction
name: carnitine transferase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_a4e24ed7_a550_477c_baa9_65179849d215
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: TPH2
is: Q8IWU9
initial amount: NaN
is encoded by: hsa:121278
has only substance units: false

metaM s2l2n2m2mn l
initial amount: NaN
boundary condition: false
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:50570
notes: FORMULA: C76H123N5O57 CHARGE: -2
is: HMDB06529
initial concentration: 1.0
type: Species

metaR GAL3ST11
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110038#
is described by: ECO:0000000
name: Galactosylceramide sulfotransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.11
reactant: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_eb776509_1506_48f7_aad9_775304b6d05d
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: P51857
name: AKR1D1
has only substance units: false
is encoded by: hsa:6718
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_f117f069_0c27_4296_87dc_09ecc31ab5b2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O95263
has only substance units: false
constant: false
is encoded by: hsa:8622
type: Species
name: PDE8B
initial amount: NaN

metaR CBASPte
name: Transport of N-carbamoyl-L-aspartate
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000185
reactant: MODEL1310110038#
reversible: true
is described by: ECO:0000134

metaM 3tetd7ecoacrn c
notes: FORMULA: C21H39NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
name: 3-hydroxy tetradecenoyl-7-carnitine
initial amount: NaN
constant: false
is: HMDB02014

metaM 56dthm m
initial amount: NaN
is: CHEBI:27468
has only substance units: false
is: HMDB00079
boundary condition: false
name: 5,6-dihydrothymine
constant: false
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
type: Species
initial concentration: 1.0

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaM fadh2 m
initial amount: NaN
is: CHEBI:58307
type: Species
has only substance units: false
name: Flavin adenine dinucleotide reduced
constant: false
is: SBO:0000247
is: C01352
is: HMDB01197
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaM arachd x
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
boundary condition: false
name: arachidonate
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:32395

metaR URIDK2m
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
reactant: MODEL1310110038#
reversible: true
name: uridylate kinase (dUMP), mitochondrial
is: SBO:0000176
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110038#

metaM dgtp c
is: HMDB01440
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
is: SBO:0000247
is: C00286
initial amount: NaN
constant: false
is: CHEBI:16497
name: dGTP

metaR MANt1r
name: mannose transport (uniport)
fast: false
reversible: true
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
is: SBO:0000185
type: Reaction

metaR GAMt1r
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
fast: false
modifier: MODEL1310110038#
reversible: true
name: glucosamine transport (uniport)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_416edb33_54e8_44e7_9436_6d6f432fe921
initial amount: NaN
has only substance units: false
is encoded by: hsa:3038
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: HAS3
is: Q96RV2

metaR G14T2g
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d568a577_dccd_4afb_a487_ea74e82953ae
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:AA203143
constant: false
name: _AA203143_1_c
is: SBO:0000252
initial concentration: NaN

metaR r0389
reactant: MODEL1310110038#
product: MODEL1310110038#
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000176

metaM ksi pre15 g
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 15
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: C00130
constant: false
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110038#_4d7da1d9_39d6_426f_973f_11028ab7ba29
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23530
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NNT

metaM 3dhguln c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB06334
has only substance units: false
name: 3-dehydro-L-gulonate
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57655
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1

metaM 5thf e
type: Species
constant: false
initial concentration: 1.0
is: HMDB06487
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H45N11O18 CHARGE: -6
name: pentaglutamyl folate (THF)
initial amount: NaN

metaR S6T18g
product: MODEL1310110038#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.21
is version of: http://identifiers.org/ec-code/2.8.2.17
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110038#_a5a63279_516c_4cca_8d3e_162fdb5394c8
initial amount: NaN
name: AGMAT
is: Q9BSE5
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:79814
is: SBO:0000252
type: Species
has only substance units: false

metaM pdx5p c
constant: false
is: HMDB01319
initial concentration: 1.0
type: Species
name: Pyridoxine 5'-phosphate
has only substance units: false
boundary condition: false
is: CHEBI:58589
is: SBO:0000247
initial amount: NaN
is: C00627
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627

http://identifiers.org/biomodels.db/MODEL1310110038#_73b08e9b_0517_403a_acd0_5fa442e0b7e7
name: NT5C1B
has only substance units: false
constant: false
type: Species
is encoded by: hsa:93034
initial amount: NaN
is: Q96P26
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM prpncoa m
is: HMDB02307
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
initial concentration: 1.0
name: acryloyl-CoA(4-)
is: CHEBI:57367
has only substance units: false
boundary condition: false

metaM core2 g
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
name: Core 2
constant: false
type: Species
has only substance units: false
is: CHEBI:15876
initial amount: NaN
boundary condition: false

metaR 4NPHSFte
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is described by: ECO:0000000
is: SBO:0000185
name: xenobiotic transport
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR r0483
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110038#
reversible: true

metaM 3tetd7ecoacrn e
notes: FORMULA: C21H39NO5 CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
name: 3-hydroxy tetradecenoyl-7-carnitine
is: HMDB02014
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_363cb2e3_4768_4ffa_8b3a_7a5e8d03f8be
name: _AI620219_1_c
initial amount: NaN
is encoded by: hsa:AI620219
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_46ca156d_4fff_4feb_8a5e_6c4b771730f8
name: VNN3
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55350
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_c3966966_ff6a_4506_beaa_ba650d44fbd4
name: SLC9A5
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6553
has only substance units: false
is: Q9NSW9

http://identifiers.org/biomodels.db/MODEL1310110038#_d7610492_da63_4623_be1f_6afa84990d2a
type: Species
is encoded by: hsa:10935
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: PRDX3
is: P30048
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_2846aa57_8cac_4629_b9ad_52b2d22c8c18
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: PKLR
is encoded by: hsa:5313
initial concentration: NaN
has only substance units: false

metaR GALt4
fast: false
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
name: galactose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#

metaR DCK2n
reversible: true
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is described by: ECO:0000269
reactant: MODEL1310110038#
is: SBO:0000176
type: Reaction
name: Deoxycytidine kinase, nuclear (UTP)

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR LEUKTRF4t
name: leukotriene F4 transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
fast: false
reversible: true
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_83720457_9a7d_4e54_92c5_25066c809dae
constant: false
is encoded by: hsa:27115
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: PDE7B
has only substance units: false
is: Q9NP56
is: SBO:0000252

metaR G5SADrm
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
type: Reaction

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
reversible: false
type: Reaction
modifier: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: hydrolysis of cholesterol ester by cholesterol esterase
reactant: MODEL1310110038#

metaR SAMHISTA
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
fast: false
is: SBO:0000176
modifier: MODEL1310110038#
is described by: ECO:0000269
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.8
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR C4CRNCPT2
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaM ptth m
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:16753
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
is: HMDB03426
initial concentration: 1.0

metaM pail5p hs n
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
boundary condition: false
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

metaM prpp e
initial concentration: 1.0
constant: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: CHEBI:58017
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00280

metaR r0394
is described by: ECO:0000000
reactant: MODEL1310110038#
fast: false
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is: SBO:0000176

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/2.3.1.61
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110038#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)

metaM lnlncg l
constant: false
is: CHEBI:32391
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
type: Species
name: gamma-linolenate
has only substance units: false
is: SBO:0000247
is: HMDB03073
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_11810e99_761f_4d9d_8d85_90efa6495964
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CCBL1
constant: false
is encoded by: hsa:883
initial amount: NaN
type: Species
is: Q16773

http://identifiers.org/biomodels.db/MODEL1310110038#_b02f5182_104a_4b6f_a788_563f02dc1ad7
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: MGAT1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4245
is: P26572

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110038#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
modifier: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110038#
is described by: ECO:0000000

metaM abt e
constant: false
is: SBO:0000247
type: Species
is: CHEBI:18403
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: L-arabinitol
is: HMDB01851

http://identifiers.org/biomodels.db/MODEL1310110038#_252ba3d7_1c59_4151_abd3_b60ec0be6017
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: AK5
is: SBO:0000252
is encoded by: hsa:26289
is: Q9Y6K8
constant: false
type: Species

metaM 3hdcoa c
is: SBO:0000247
boundary condition: false
name: (S)-3-Hydroxydecanoyl-CoA
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB13325
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaM sprm e
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01256
is: CHEBI:45725
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
name: spermine(4+)
type: Species

metaM mmcoa R m
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
has only substance units: false
is: CHEBI:57326
is: HMDB01269
boundary condition: false
name: (R)-methylmalonyl-CoA(5-)
type: Species

metaR DM anth
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM 4abut m
has only substance units: false
constant: false
initial amount: NaN
name: 4-Aminobutanoate
is: SBO:0000247
is: HMDB00112
is: C00334
initial concentration: 1.0
type: Species
is: CHEBI:16865
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334

metaM ksi deg1 e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:17268
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
has only substance units: false
is: HMDB00211
constant: false
type: Species
initial concentration: 1.0

metaR SPHS1Pte
product: MODEL1310110038#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
reversible: true

metaR GALASE1ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
kinetic law: MODEL1310110038#
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176

metaR r0393
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.74
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
is: SBO:0000176
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
reversible: false

metaR PItg
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
reversible: false
name: phosphate transport, Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110038#_fb487087_a642_4f55_9e21_b9ed6a009919
is encoded by: hsa:223
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: P49189
initial concentration: NaN
constant: false
name: ALDH9A1
initial amount: NaN

metaM fadh2 x
initial concentration: 1.0
type: Species
is: HMDB01197
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
is: CHEBI:58307
name: FADH2(2-)
is: SBO:0000247
constant: false

metaR S6TASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: true
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110038#_1bb4361b_56cc_4930_a835_24a244b0eeff
is: SBO:0000252
is: Q4KWH8
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:23007
initial concentration: NaN
name: PLCH1

metaR DDCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM Rtotal3 e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00244
is: CHEBI:3554
type: Species
name: R total 3 position
has only substance units: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: C00255

metaR r1559
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 5mta c
constant: false
is: HMDB01173
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: C00170
is: SBO:0000247
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
is: CHEBI:17509
name: 5-Methylthioadenosine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c47ecef9_89fd_46ff_961e_df646771ac0f
boundary condition: true
is encoded by: hsa:2731
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: P23378
name: GLDC
is: SBO:0000252

metaM glyc3p c
is: CHEBI:57597
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
constant: false
boundary condition: false
is: C00093
name: Glycerol 3-phosphate
initial amount: NaN

metaM cholp c
type: Species
is: SBO:0000247
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:295975
name: choline phosphate(1-)

metaR UAGDP
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.23
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000269

metaM thcholstoic x
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
is: CHEBI:18402
is: HMDB03873
has only substance units: false

metaM cs a deg2 l
constant: false
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
type: Species
initial amount: NaN
is: HMDB00127
has only substance units: false
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C37H55NO38S2 CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_7a1b9d6e_214c_481d_b77a_be8728a348c2
type: Species
name: NDUFV1
is encoded by: hsa:4723
is: E5KNH5
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaM nh4 n
constant: false
name: ammonium
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:28938
initial concentration: 1.0
is: HMDB00051
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_941d06c2_0e97_4222_8668_6f0e2a7d761c
has only substance units: false
type: Species
initial concentration: NaN
name: CTPS1
boundary condition: true
is encoded by: hsa:1503
is: P17812
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6bf537bc_7270_4cfc_bf47_1f034fc33d52
name: HPGDS
constant: false
is: SBO:0000252
is: O60760
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27306
type: Species
initial amount: NaN
boundary condition: true

metaR EX adp
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

metaM frdp x
is: CHEBI:175763
is: HMDB00961
is: SBO:0000247
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)
constant: false
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
type: Species
initial amount: NaN

metaR RNDR2
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (GDP)
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
fast: false
is described by: ECO:0000254
is: SBO:0000176
reversible: false

metaM m1mpdol U c
initial amount: NaN
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067
has only substance units: false
type: Species
boundary condition: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_6f1360d9_1a5c_4408_baec_183c6796c00a
is: SBO:0000252
is: Q9H999
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PANK3
type: Species
has only substance units: false
is encoded by: hsa:79646

metaR BALAtmr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
reversible: true
fast: false
type: Reaction
product: MODEL1310110038#

metaM em2emgacpail hs r
initial amount: NaN
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
has only substance units: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM nh4 m
constant: false
name: Ammonium
is: C01342
has only substance units: false
is: SBO:0000247
is: CHEBI:28938
boundary condition: false
is: HMDB00051
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR ALAt2r
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
name: L-alanine reversible transport via proton symport
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
reversible: true

metaR RE3626M
fast: false
reversible: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
name: RE3626
modifier: MODEL1310110038#

metaM fuc L c
initial concentration: 1.0
initial amount: NaN
name: L-fucose
has only substance units: false
is: HMDB00174
type: Species
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
is: SBO:0000247
boundary condition: false

metaM tettet6coa x
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481
boundary condition: false
name: tetracosatetraenoyl coenzyme A
has only substance units: false
is: C16171
constant: false
is: HMDB06516
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_73267f9a_51b8_4286_bcff_aaeea81d1a50
type: Species
boundary condition: true
name: SLC22A1
is encoded by: hsa:6580
is: O15245
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaR ICDHy
modifier: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
reversible: false
fast: false
type: Reaction
name: isocitrate dehydrogenase (NADP)

http://identifiers.org/biomodels.db/MODEL1310110038#_849711af_1215_4ea0_a83e_53cfc76d8476
type: Species
name: HAO2
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:51179
initial concentration: NaN
has only substance units: false
constant: false

metaM pristanal x
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:49189
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
is: HMDB01958
is: SBO:0000247
type: Species
name: pristanal

metaM ach n
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: acetylcholine
is: CHEBI:15355
has only substance units: false
is: HMDB00895
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

http://identifiers.org/biomodels.db/MODEL1310110038#_3841d0d3_9778_4fb3_a2c5_c109317834ae
has only substance units: false
is: P15531
name: NME1
is encoded by: hsa:4830
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaM udpgal c
is: HMDB00302
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:58439
is: SBO:0000247

metaR r1557
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
type: Reaction
reversible: true

metaM cytd e
initial amount: NaN
name: Cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
is: HMDB00089
is: CHEBI:17562
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

metaR r0390
is: SBO:0000176
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
type: Reaction

metaM HC01403 m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28325
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110038#_2eb88901_62e9_4da2_9f30_b7613d1d7bf5
is: O95470
name: SGPL1
initial amount: NaN
boundary condition: true
is encoded by: hsa:8879
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaM 6hoxmelatn c
is: HMDB04081
is: SBO:0000247
is: C05643
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/7954
boundary condition: false
name: 6-Hydroxymelatonin

metaR LNLNCACPT2
name: carnitine transferase
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaR MAN6PI
modifier: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000304
fast: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/5.3.1.8
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
name: mannose-6-phosphate isomerase

http://identifiers.org/biomodels.db/MODEL1310110038#_c3a0e406_3a91_4313_8215_b9a51b83bae7
initial concentration: NaN
is: P08319
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:127
boundary condition: true
name: ADH4
has only substance units: false
initial amount: NaN

metaR r0179
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110038#_01804e66_2c48_4fd8_89d2_a88500dfe4a2
name: SLC9A1
is encoded by: hsa:6548
is: P19634
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR PROt4 2 r
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110038#
name: Proline transport (sodium symport) (2:1)
fast: false
is described by: ECO:0000006
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#

metaM btn n
has only substance units: false
is: HMDB00030
type: Species
constant: false
is: CHEBI:57586
boundary condition: false
is: SBO:0000247
name: biotinate
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
initial amount: NaN

metaR DASCBR
type: Reaction
reactant: MODEL1310110038#
name: dehydroascorbate reductase
fast: false
modifier: MODEL1310110038#
reversible: false
is described by: ECO:0000269
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
kinetic law: MODEL1310110038#

metaM fuc L e
constant: false
is: HMDB00174
is: CHEBI:18287
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
name: L-fucose
boundary condition: false
has only substance units: false
initial amount: NaN

metaR DOLMANP Lter
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000185
fast: false
name: dolichol-phosphate mannose flippase (liver)
reversible: false
product: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_568f47a2_6399_4680_aa7f_9836c63d41b0
is: SBO:0000252
constant: false
name: NDUFB1
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4707
initial amount: NaN
is: O75438

metaM lnlncg e
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
initial concentration: 1.0
is: CHEBI:32391

http://identifiers.org/biomodels.db/MODEL1310110038#_d8d80ab7_aa45_42e0_8e3d_e384df0821a0
type: Species
is encoded by: hsa:8525
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: B7Z2M9
name: DGKZ
boundary condition: true

metaM pan4p m
name: pantetheine 4'-phosphate(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01416
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_d6f5107b_62d5_4858_80cb_50426c9b36f1
name: DDOST
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P39656
is: SBO:0000252
constant: false
is encoded by: hsa:1650
has only substance units: false
type: Species

metaR LNLNCACPT1
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction

metaM abt c
is: HMDB01851
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false
name: L-arabinitol
initial amount: NaN
type: Species
is: CHEBI:18403

metaM cytd c
is: HMDB00089
name: Cytidine
is: CHEBI:17562
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00475
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaM cs b l
is: HMDB02183
boundary condition: false
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
has only substance units: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
type: Species

metaR GDPtg
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
reactant: MODEL1310110038#
reversible: true
name: GDP intracellular transport
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185

metaM udpgal e
constant: false
name: UDP-D-galactose(2-)
type: Species
is: CHEBI:58439
is: SBO:0000247
is: HMDB00302
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial amount: NaN

metaR ORPT
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
fast: false
type: Reaction
name: orotate phosphoribosyltransferase
modifier: MODEL1310110038#

metaM btn m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57586
name: biotinate
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
type: Species
constant: false
initial amount: NaN

metaR MECOALm
modifier: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000212
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110038#
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
fast: false

metaM prpp c
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00280
is: SBO:0000247
is: C00119
is: CHEBI:58017
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species
initial amount: NaN
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false

metaM lnlncacoa c
initial amount: NaN
type: Species
name: alpha-Linolenoyl-CoA
is: HMDB06290
is: CHEBI:51985
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
has only substance units: false
boundary condition: false

metaM for r
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
is: C00058
constant: false
initial concentration: 1.0
is: CHEBI:15740
is: SBO:0000247
initial amount: NaN
is: HMDB00142
boundary condition: false
name: Formate
has only substance units: false

metaR r0392
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reversible: true
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM ksi deg41 l
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
boundary condition: false
name: keratan sulfate I, degradation product 41
is: HMDB00143
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_7204e71a_4590_4e13_92d4_e9c226cc11dd
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: Q9Y6M9
is: SBO:0000252
type: Species
name: NDUFB9
is encoded by: hsa:4715

http://identifiers.org/biomodels.db/MODEL1310110038#_ffdc7f27_9713_4973_a174_a6f92f769bbf
is encoded by: hsa:766
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: CA7
is: P43166
type: Species
constant: false
initial concentration: NaN

metaM Lpipecol x
is: CHEBI:30913
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: L-pipecolic acid
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00716
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408

http://identifiers.org/biomodels.db/MODEL1310110038#_7b301e6a_1cc7_4363_a58f_cd485d52b8a8
name: CYP1A2
type: Species
is: P05177
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1544
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_2da48549_8fcc_47be_832c_51f1e2791984
is: O43252
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:9061
is: SBO:0000252
initial concentration: NaN
constant: false
name: PAPSS1
initial amount: NaN

metaR FAOXC121C101m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR r1556
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110038#
is described by: ECO:0000000

metaM od2coa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
name: trans-Octadec-2-enoyl-CoA
is: HMDB06529
type: Species
is: CHEBI:50570
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_ab78fbb4_c3e5_4ceb_8ae6_2eb67788982c
has only substance units: false
constant: false
is encoded by: hsa:728226
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _728226_1_m
is: SBO:0000252

metaR r0391
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110038#

metaM 3hdcoa m
type: Species
initial concentration: 1.0
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966

metaM 10fthf c
boundary condition: false
constant: false
is: CHEBI:57454
is: HMDB00972
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
is: C00234
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_d6f74d34_cf25_4a67_8147_727e8d92d9e0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACP6
has only substance units: false
is encoded by: hsa:51205
is: Q9NPH0
type: Species
constant: false
boundary condition: true

metaM q10 m
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01072
constant: false
has only substance units: false
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
initial amount: NaN
is: CHEBI:46245

http://identifiers.org/biomodels.db/MODEL1310110038#_53fc892c_80fb_4c53_944d_0ca036e49bd0
is: Q9P0J0
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:51079
name: NDUFA13
initial concentration: NaN

metaR r1553
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_e3315dd3_f4a6_4337_a3a3_d7bda9e6af72
initial amount: NaN
is: SBO:0000252
is: Q16222
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6675
has only substance units: false
name: UAP1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_3bde6e1e_b182_4696_8dc0_99a2815443c1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: ATG9B
is: SBO:0000252
is encoded by: hsa:285973
boundary condition: true
is: Q674R7
has only substance units: false

metaR PItn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: phosphate transport, nuclear
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#

metaM gtp c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01273
is: CHEBI:37565
type: Species
constant: false
is: C00044
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP

metaR ACCOAC
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r1614
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR DNDPt8m
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: false
name: dADP transport via dUDP antiport
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_22086667_839f_4bbe_a345_4b87304ab0bc
is: P24311
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: COX7B
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1349

metaM 3ttetddcoacrn c
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial concentration: 1.0
notes: FORMULA: C21H37NO5 CHARGE: 0
type: Species
has only substance units: false
constant: false
is: HMDB02014
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_566df386_c467_4733_b4f4_eba4a03a606a
has part: Q86YI5
type: Species
is encoded by: hsa:5162
name: DLAT:DLD:PDHA2:PDHB:PDHX
has part: P29803
is encoded by: hsa:1737
boundary condition: true
is: SBO:0000297
initial amount: NaN
constant: false
has part: P11177
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5161

metaR r2099
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_f3c9ebbf_ac84_447e_8e6b_3531e781ceee
constant: false
initial amount: NaN
name: ADSSL1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q8N142
is encoded by: hsa:122622

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_176cc902_993e_40fd_a031_1f247c4c9394
type: Species
initial concentration: NaN
has only substance units: false
is: P25705
initial amount: NaN
is encoded by: hsa:498
name: ATP5A1
constant: false
boundary condition: true
is: SBO:0000252

metaR r0022
is version of: http://identifiers.org/ec-code/1.8.1.7
type: Reaction
kinetic law: MODEL1310110038#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_b31bbaaf_a774_4d9d_b22d_bf536d265b92
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: SLC4A5
constant: false
initial concentration: NaN
is encoded by: hsa:57835

metaR r1554
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_65a9251f_395d_4157_af1f_1f502e71a99a
is encoded by: hsa:6240
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: RRM1
is: SBO:0000252
boundary condition: true
is: P23921
initial amount: NaN

metaR r1401
reversible: false
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.51
is version of: http://identifiers.org/ec-code/2.7.10.1
is version of: http://identifiers.org/ec-code/3.1.1.3
is version of: http://identifiers.org/ec-code/3.2.1.35
product: MODEL1310110038#
fast: false
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM trdrd m
boundary condition: false
is: CHEBI:15967
constant: false
initial amount: NaN
name: Reduced thioredoxin
type: Species
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: SBO:0000247
has only substance units: false

metaR r1615
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_23a9925d_fefb_4946_a16c_ebf7aaf8d42c
name: DGKG
constant: false
is: SBO:0000252
boundary condition: true
is: P49619
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:1608
initial amount: NaN

metaM od2coa c
is: C16218
is: CHEBI:50570
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
name: trans-Octadec-2-enoyl-CoA
has only substance units: false
type: Species
is: HMDB06529

http://identifiers.org/biomodels.db/MODEL1310110038#_925fac90_2081_47f3_b166_76e3742976ca
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: ST3GAL1
constant: false
is encoded by: hsa:6482
type: Species
initial concentration: NaN

metaM nrvnc e
initial amount: NaN
boundary condition: false
name: nervonate
has only substance units: false
is: HMDB02368
is: CHEBI:32392
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-

metaR GALASE8ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110038#_66bf4850_d99d_40b8_aa63_2d53a9a8a3a5
constant: false
type: Species
initial amount: NaN
name: _AA278423_1_m
is encoded by: hsa:AA278423
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM 3mop m
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
has only substance units: false
initial amount: NaN
is: CHEBI:28654
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: HMDB00491

metaR r2098
product: MODEL1310110038#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110038#

metaR C226CPT1
fast: false
name: carnitine C22:6 transferase
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV

metaM ptth c
boundary condition: false
is: SBO:0000247
is: HMDB03426
name: pantetheine
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
is: CHEBI:16753

metaR 5ADTSTSTERONEte
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110038#
name: 5 alpha dihydrotesterone transport

metaR PROSTGI2tr
reversible: true
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: Prostaglandin I2 transport (ER)
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

metaM lnlncg r
has only substance units: false
constant: false
is: SBO:0000247
name: gamma-linolenate
type: Species
is: HMDB03073
initial concentration: 1.0
boundary condition: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR r1612
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaR r1551
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GALASE10ly
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110038#
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction

metaM citr L m
initial amount: NaN
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
boundary condition: false
is: CHEBI:16349
is: SBO:0000247
name: L-citrulline
initial concentration: 1.0
type: Species
has only substance units: false

metaR TRIOK
type: Reaction
name: triokinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false

metaM 3ttetddcoacrn e
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial concentration: 1.0
notes: FORMULA: C21H37NO5 CHARGE: 0
type: Species
constant: false
is: HMDB02014
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_0a9bae62_1e6e_4f7c_8bb6_51a7a1105a63
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3295
type: Species
constant: false
is: E9PB82
name: HSD17B4
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR C226CPT2
product: MODEL1310110038#
name: C226 transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110038#

metaR r0698
is version of: http://identifiers.org/ec-code/3.1.2.27
modifier: MODEL1310110038#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:

metaR SEBCOAPET
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaM mev R c
has only substance units: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00227
is: CHEBI:36464
is: SBO:0000247
name: (R)-mevalonate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_498054ff_ae50_4281_9418_44473a835e2d
has only substance units: false
boundary condition: true
is encoded by: hsa:3948
is: SBO:0000252
constant: false
name: LDHC
type: Species
initial concentration: NaN
is: P07864
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_e8288f34_7ed4_4cef_b453_079783850e01
type: Species
constant: false
is: P00374
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1719
has only substance units: false
initial concentration: NaN
boundary condition: true
name: DHFR

metaR r1552
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_91b54e55_3a0a_4f3d_b677_1d7bd348f887
is: P24666
constant: false
is: SBO:0000252
type: Species
name: ACP1
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:52
initial concentration: NaN

metaM nh4 e
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:28938
boundary condition: false
is: HMDB00051
has only substance units: false
name: ammonium
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR r1613
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_8b4eb4ed_eeb5_4a83_a7af_2bb09fd06654
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q92536
name: SLC7A6
constant: false
is: SBO:0000252
is encoded by: hsa:9057

http://identifiers.org/biomodels.db/MODEL1310110038#_3d77bc54_d4fb_4d0b_b1a9_fdf786947434
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:29920
boundary condition: true
is: Q96C36
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PYCR2

metaR RE1526M
is: SBO:0000176
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110038#
type: Reaction
name: RE1526
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_a72420b7_bc8d_42de_985e_d3ebe4678b33
is encoded by: hsa:4715
initial concentration: NaN
is: Q9Y6M9
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFB9
boundary condition: true
type: Species

metaR MTHGXLt
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
name: Methylglyoxal transport (cytosol to extracellular)
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaM nrvnc c
boundary condition: false
has only substance units: false
name: nervonate
initial amount: NaN
is: HMDB02368
is: CHEBI:32392
type: Species
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_8baeac5a_16c9_4236_b804_9e6e3b2afd20
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1737
initial concentration: NaN
name: DLAT
is: SBO:0000252
is: Q86YI5

metaR FBA2
reversible: true
reactant: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000304
kinetic law: MODEL1310110038#
fast: false
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
type: Reaction
modifier: MODEL1310110038#

metaR RNDR4
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (UDP)
product: MODEL1310110038#
is described by: ECO:0000254
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: false
is: SBO:0000176
type: Reaction

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM acmana e
constant: false
is: CHEBI:17122
initial concentration: 1.0
has only substance units: false
name: N-acetyl-D-mannosamine
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01129
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645

metaR r0027
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.13.39

metaR CYTDK2m
fast: false
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
reversible: false

metaR G14Tg
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction

metaM fuc L l
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
name: L-fucose
type: Species
boundary condition: false
has only substance units: false
is: HMDB00174
is: SBO:0000247
is: CHEBI:18287

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d006efe3_c9be_42e2_8fbf_304ff9ab3d2d
initial amount: NaN
name: AK4
has only substance units: false
is encoded by: hsa:205
is: P27144
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM cytd n
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: cytidine
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
is: CHEBI:17562
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00089

http://identifiers.org/biomodels.db/MODEL1310110038#_64cd1ab3_e7f2_4de2_b7f7_246795f50d94
initial amount: NaN
name: _AI971023_1_c
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI971023
constant: false

metaM lnlncacoa m
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: HMDB06290
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:51985
boundary condition: false
name: alpha-Linolenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110038#_a9441a1f_65c2_4a3e_8424_0461a0b1b324
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:30
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
name: ACAA1
is: Q96CA6

metaR r1618
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b2459e79_160d_4595_983e_6c18a46749d9
is: SBO:0000252
constant: false
is encoded by: hsa:3945
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: LDHB
is: P07195

metaR THRPHELAT2tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR RNDR3
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (CDP)
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM tcynt m
is: CHEBI:18022
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01453
initial amount: NaN
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
boundary condition: false

metaR DHFtm
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: dihydrofolate reversible mitochondrial transport
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaR r1619
product: MODEL1310110038#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110038#

metaM dgmp e
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
name: dGMP(2-)
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01044

metaM n2m2nmn l
is: CHEBI:17588
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C50H84N4O36 CHARGE: 0
boundary condition: false
has only substance units: false
is: HMDB00742
constant: false

metaM ksii core4 pre1 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1
initial concentration: 1.0
is: CHEBI:28067
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C36H60N3O25X CHARGE: 0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c6fc7547_d680_45ba_8c32_51ff45a03df4
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3631
name: INPP4A
constant: false
is: Q96PE3
boundary condition: true
has only substance units: false

metaM btn e
type: Species
is: SBO:0000247
is: CHEBI:3420
constant: false
initial amount: NaN
is: C00120
has only substance units: false
initial concentration: 1.0
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
is: HMDB00030

metaM acmana c
name: N-acetyl-D-mannosamine
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01129
constant: false
is: CHEBI:17122
boundary condition: false

metaR FBA4
modifier: MODEL1310110038#
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000269
type: Reaction
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_78f0fe3b_a829_42d5_89a0_8bc9d4b6b6d8
is encoded by: hsa:LOC728997
constant: false
type: Species
is: SBO:0000252
name: _LOC728997_1_c
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR UMPK4n
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110038#
name: UMP kinase (GTP),nuclear
reactant: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_efcc11da_56a1_4f45_be70_9cdd2e9c787c
is: P42765
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10449
type: Species
name: ACAA2
initial concentration: NaN
constant: false
has only substance units: false

metaR r1616
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

metaR TMDPK
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110038#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9cc874c6_5b4a_41c4_80cf_c03920c089d7
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:8309
has only substance units: false
initial amount: NaN
name: ACOX2
boundary condition: true
is: Q99424
constant: false

metaM gacpail hs c
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01401
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548
is: C00092
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_b169c020_4c16_40f8_8b3b_0da8fbf5615d
is encoded by: hsa:55907
constant: false
initial amount: NaN
has only substance units: false
is: Q8NFW8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: CMAS

metaM doco13ecoa x
is: http://identifiers.org/pubchem.compound/24892791
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: 13-docosenoylcoa
has only substance units: false
initial amount: NaN

metaM c10dc c
boundary condition: false
notes: FORMULA: C17H30NO6 CHARGE: -1
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB13325
initial amount: NaN
name: sebacoyl carnitine

metaR FAOXC180
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
product: MODEL1310110038#
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM Rtotal3 c
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16189
name: R total 3 position
boundary condition: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
type: Species

metaM HC01405 m
constant: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
is: CHEBI:28632
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (S)-Hydroxyoctanoyl-CoA
boundary condition: false
initial amount: NaN

metaR PCRNtc
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
kinetic law: MODEL1310110038#
is: SBO:0000185
fast: false
type: Reaction
name: transport into the cytosol from peroxisome (carnitine)
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: false

metaM dgmp c
boundary condition: false
type: Species
constant: false
is: CHEBI:57673
is: HMDB01044
initial concentration: 1.0
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: SBO:0000247
name: dGMP
initial amount: NaN
has only substance units: false

metaM 3hdececrn c
name: 3-hydroxyhexadecenoylcarnitine
notes: FORMULA: C23H43NO5 CHARGE: 0
is: HMDB02014
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM 2hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species
has only substance units: false
boundary condition: false
is: HMDB02288

metaR MI1P Dtn
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
reversible: true
name: inositol 1-phosphate nuclear transport (diffusion)
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM sprm c
initial concentration: 1.0
is: HMDB01256
boundary condition: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
name: spermine(4+)
is: CHEBI:45725
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaM cytd m
boundary condition: false
initial amount: NaN
name: cytidine
is: SBO:0000247
is: HMDB00089
constant: false
is: CHEBI:17562
type: Species
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial concentration: 1.0

metaR r1617
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110038#

metaR PI45P5P
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
type: Reaction
reversible: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
reversible: false
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000269
product: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.13.11.27

metaR r0937
reversible: true
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#
name: Transport reaction
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR LEUKTRE4t
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110038#
reversible: true
name: leukotriene E4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110038#

metaM 3hdececrn e
notes: FORMULA: C23H43NO5 CHARGE: 0
type: Species
boundary condition: false
is: HMDB02068
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: 3-hydroxyhexadecenoylcarnitine

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaR ADK1
fast: false
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
modifier: MODEL1310110038#
name: adenylate kinase
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110038#

metaR ACOAD9m
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
kinetic law: MODEL1310110038#
reversible: false
is described by: ECO:0000269

metaM arg L c
has only substance units: false
name: L-argininium(1+)
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
is: SBO:0000247
is: CHEBI:32682
is: HMDB00517

metaR FAOXC11C9m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_ef6d9d77_9ea3_4d15_b2cc_ca9cf6e1fd61
has only substance units: false
initial amount: NaN
constant: false
name: HLCS
is encoded by: hsa:3141
is: P50747
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR ITPtn
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
reversible: true
is: SBO:0000185
name: ITP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#

metaM mev R x
has only substance units: false
name: (R)-mevalonate
is: HMDB00227
initial concentration: 1.0
constant: false
is: CHEBI:36464
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_3c33960f_fed5_454d_bd6a_8b447a5fb595
boundary condition: true
initial concentration: NaN
name: DTYMK
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: P23919
is encoded by: hsa:1841
is: SBO:0000252

metaR UAG4E
is described by: ECO:0000304
name: UDP-N-acetylglucosamine 4-epimerase
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#

metaM duri e
is: C00526
type: Species
initial amount: NaN
is: SBO:0000247
name: Deoxyuridine
is: CHEBI:16450
constant: false
initial concentration: 1.0
is: HMDB00012
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

http://identifiers.org/biomodels.db/MODEL1310110038#_3a704036_9873_42c0_89d4_257f6de9f25f
has only substance units: false
is: SBO:0000252
name: CHAT
is encoded by: hsa:1103
type: Species
boundary condition: true
initial concentration: NaN
is: Q6LEN6
initial amount: NaN
constant: false

metaR PCHOLP hs
fast: false
is: SBO:0000176
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: choline phosphatase
reactant: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: false
type: Reaction

metaR ARACHDtr
fast: false
name: intracellular transport
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#

metaR r1771
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: false

metaM prgnlone c
constant: false
is: CHEBI:16581
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00253
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
name: pregnenolone
boundary condition: false
has only substance units: false

metaM lanost r
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16521
is: HMDB01251
constant: false
name: lanosterol
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724

metaR ACP1 FMN
product: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
name: acid phosphatase (FMN)
kinetic law: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000254
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
reactant: MODEL1310110038#
type: Reaction

metaR r0242
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110038#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
modifier: MODEL1310110038#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_14ee08d9_05c7_4f1f_a025_e0ab340f317f
constant: false
initial concentration: NaN
is: Q38G75
is encoded by: hsa:2582
boundary condition: true
has only substance units: false
name: GALE
type: Species
is: SBO:0000252
initial amount: NaN

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM C05279 m
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
constant: false
initial amount: NaN
is: CHEBI:28387
is: HMDB11123
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_98a333f6_62c3_4374_99e7_b374407a0113
is: P34059
initial concentration: NaN
is encoded by: hsa:2588
boundary condition: true
constant: false
has only substance units: false
name: GALNS
initial amount: NaN
type: Species
is: SBO:0000252

metaM citr L e
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
name: citr_L[e]
boundary condition: false
initial concentration: 1.0
is: CHEBI:16349

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM duri c
type: Species
is: C00526
name: Deoxyuridine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16450
constant: false
has only substance units: false
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaM tdchola x
is: SBO:0000247
initial amount: NaN
constant: false
name: taurochenodeoxycholate
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951
is: CHEBI:9407
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_fbea43bd_329b_4399_b9b6_567d1615ce82
initial amount: NaN
is encoded by: hsa:5151
type: Species
constant: false
name: PDE8A
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_8141e282_ab11_4124_b76c_0c2285136795
constant: false
initial amount: NaN
type: Species
is: P48751
is encoded by: hsa:6508
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC4A3

http://identifiers.org/biomodels.db/MODEL1310110038#_2e1b8125_a844_4814_a46e_8275c3cde2b2
constant: false
has only substance units: false
initial concentration: NaN
is: Q9NR34
initial amount: NaN
is encoded by: hsa:57134
type: Species
is: SBO:0000252
name: MAN1C1
boundary condition: true

metaR r0936
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110038#
reversible: false
name: Transport reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
fast: false

metaM HC00229 e
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28189
name: Isomaltose
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252

metaR C162OHc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR FAOXC3DC
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

metaR r0170
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reversible: true
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
type: Reaction

metaR r1109
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reversible: true
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
product: MODEL1310110038#
is: SBO:0000176

metaR DM gpi sig er
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR C141CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaM L2aadp c
constant: false
has only substance units: false
is: CHEBI:58672
name: L-2-aminoadipate(1-)
is: HMDB00510
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR AMPtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
name: AMP transporter, peroxisome
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#

metaR RE1525M
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110038#
name: RE1525
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_8c2ab76c_4a91_4b82_b055_f90a79f8a566
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:83549
is: Q5JT09
boundary condition: true
constant: false
name: UCK1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_69e088df_ec81_4e4f_87a1_3411892c2a03
is encoded by: hsa:4329
is: SBO:0000252
name: ALDH6A1
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: Q02252

metaR D3AIBTm
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110038#
reversible: true
fast: false
reactant: MODEL1310110038#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR RE2677E
reversible: false
product: MODEL1310110038#
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
is described by: ECO:0000000
name: RE2677
type: Reaction

metaR GLCAASE9ly
reversible: false
modifier: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#
name: beta-glucuronidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false

metaR r1623
reactant: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR NDPK8n
modifier: MODEL1310110038#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110038#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

metaR URAt
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
product: MODEL1310110038#
name: uracil transport via facilated diffusion
is: SBO:0000185
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110038#
is described by: ECO:0000269

metaR AKR1D2
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
reversible: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d3884e50_4b5e_46be_bce6_ae9ae9705c46
is: O75414
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:10201
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: NME6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_a0d33a8b_1e50_4e36_a1a2_b5e71c73ee4c
boundary condition: true
name: COQ6
initial amount: NaN
has only substance units: false
is: Q9Y2Z9
type: Species
is encoded by: hsa:51004
initial concentration: NaN
is: SBO:0000252
constant: false

metaR SCP22x
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176

metaR RE1447N
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
name: RE1447
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reversible: true
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#

metaM ura e
boundary condition: false
name: uracil
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00300

metaR r0245
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR C162OHe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaR GALU
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: UTP-glucose-1-phosphate uridylyltransferase
kinetic law: MODEL1310110038#

metaR r1622
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM CE1944 c
initial amount: NaN
name: 1-pyrrolinium
is: CHEBI:36781
is: SBO:0000247
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM cortsn r
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:16962
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
is: HMDB02802
name: cortisone

http://identifiers.org/biomodels.db/MODEL1310110038#_45b5ad09_98b3_4b73_8d73_192cb5c976f9
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: _PRO1933_1_m
type: Species
is encoded by: hsa:PRO1933

metaM cdpea c
constant: false
initial amount: NaN
is: HMDB01564
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57876
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
name: cdpea[c]
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6b4bc809_6cd9_420e_a3fe_63823313484c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80025
type: Species
name: PANK2
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR PI5P3K
is: SBO:0000176
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.137
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
type: Reaction
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol-5-phosphate 3-kinase
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_4e41af95_7ae3_4e91_832b_3d04a16a37e7
is encoded by: hsa:5290
is: SBO:0000297
is encoded by: hsa:5296
name: PIK3CA:PIK3R2
has only substance units: false
initial concentration: NaN
type: Species
has part: O00459
constant: false
has part: P42336
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_fe711a0b_c005_4786_a7b1_f71254b864fb
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: CANT1
initial amount: NaN
boundary condition: true
is: Q8WVQ1
is encoded by: hsa:124583
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_61f1af0c_3caa_4bd8_8f02_772823509402
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:27430
name: MAT2B:MAT2A
is: SBO:0000297
has part: Q9NZL9
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_8166285b_7a5b_4010_87f7_a371538fb8f9
has only substance units: false
is: SBO:0000252
type: Species
name: ENTPD3
is: O75355
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:956

metaR FAOXC12DCc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR r0246
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#

metaM pail5p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
has only substance units: false
boundary condition: false

metaM thcholstoic m
is: HMDB03873
has only substance units: false
is: CHEBI:18402
is: SBO:0000247
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
type: Species
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
boundary condition: false

metaR r1621
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
type: Reaction
reversible: true

metaM 5HPET c
boundary condition: false
is: HMDB01193
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57450
name: 5(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_d8bb05a1_0731_49d7_a9b8_e5ed35782a0d
name: SLC25A1
has only substance units: false
is: D9HTE9
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6576
initial concentration: NaN

metaR GALT
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
name: galactose-1-phosphate uridylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110038#_5c6a6250_1f6f_46d2_b192_6ad12d2c61f3
boundary condition: true
is encoded by: hsa:1376
has only substance units: false
initial amount: NaN
is: P23786
is: SBO:0000252
type: Species
name: CPT2
constant: false
initial concentration: NaN

metaR r0931
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110038#
fast: false
type: Reaction
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
is described by: ECO:0000000
name: Transport reaction

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110038#_69bfda9d_0157_47d7_9b13_6c8e14f438ba
has only substance units: false
name: B4GALT1:LALBA
type: Species
initial concentration: NaN
is: SBO:0000297
constant: false
has part: P00709
boundary condition: true
initial amount: NaN
is encoded by: hsa:3906

metaR r0932
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110038#
fast: false
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
reversible: true

metaR UPPN
modifier: MODEL1310110038#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.1.6
name: b-ureidopropionase
reactant: MODEL1310110038#
type: Reaction

metaR UGALGTg
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
is: SBO:0000176
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110038#_cc47751e_61d4_4fff_ab73_460c08f10df2
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: PGK1
is encoded by: hsa:5230
has only substance units: false
type: Species
boundary condition: true
is: P00558

metaM dodecanac x
type: Species
is: SBO:0000247
initial amount: NaN
name: Dodecanedioic acid
has only substance units: false
notes: FORMULA: C12H20O4 CHARGE: -2
boundary condition: false
constant: false
is: HMDB00623
initial concentration: 1.0

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR GCC2cm
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#

metaM ksii core2 pre10 g
name: keratan sulfate II biosynthesis, precursor 10
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: CHEBI:28067
boundary condition: false

metaR SPHS1Ptr
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110038#
reversible: true
fast: false
type: Reaction
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
product: MODEL1310110038#

metaM xan x
boundary condition: false
has only substance units: false
is: CHEBI:17712
type: Species
constant: false
is: C00385
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: HMDB00292
initial amount: NaN
name: Xanthine
initial concentration: 1.0
is: SBO:0000247

metaR EHGLAT2m
reversible: false
is: SBO:0000176
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000304
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
fast: false

metaR r1620
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000

metaM 10fthf e
has only substance units: false
type: Species
is: SBO:0000247
name: 10-formyltetrahydrofolate(2-)
constant: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_7619e9e4_1452_4cfe_b880_c169b2ebdd4e
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B3KT86
has only substance units: false
is encoded by: hsa:109
name: ADCY3

metaR r0021
is described by: ECO:0000000
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
fast: false
is: SBO:0000176
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reversible: true

metaR RE3567C
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_30dc168e_c0e4_491f_8463_7eb14e09e393
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: HADHB
is: P55084
boundary condition: true
is encoded by: hsa:3032
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1f02486e_227f_443e_ac68_1945b7a344ff
is: O00219
name: HAS3
is encoded by: hsa:3038
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_03dece53_7b3e_4416_8448_b3a366801f7d
boundary condition: true
has only substance units: false
is: Q6FH48
type: Species
is encoded by: hsa:443
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: ASPA

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_e8ceaf4a_f12d_4ff9_b87a_5f290147a259
is encoded by: hsa:220
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALDH1A3
boundary condition: true
type: Species
constant: false
is: P47895

metaM l2fn2m2masn g
initial concentration: 1.0
is: CHEBI:28067
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C68H113N4O49X CHARGE: 0
type: Species
boundary condition: false

metaM arg L m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00517
type: Species
name: L-argininium(1+)
is: CHEBI:32682
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN

metaR r0470
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_95056bd6_65ec_47a3_bbc5_545f7f440b06
name: SLC12A6
initial amount: NaN
is: Q9UHW9
initial concentration: NaN
is encoded by: hsa:9990
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_f90aef92_dfda_4b5a_878a_da07ef4febd0
name: HK2
initial amount: NaN
boundary condition: true
type: Species
is: P52789
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3099

http://identifiers.org/biomodels.db/MODEL1310110038#_6331d511_69f2_4e47_a074_d8d06863cabe
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
name: PDE2A
is encoded by: hsa:5138
boundary condition: true
has only substance units: false
is: Q8IW54

metaM thcholstoic c
initial amount: NaN
initial concentration: 1.0
is: HMDB03873
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false

metaM nh4 x
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
name: Ammonium
boundary condition: false
is: HMDB00051
is: C01342
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaM HC01104 e
name: 4-nitrophenyl phosphate(2-)
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:61146
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_70af09d2_4ce8_41f9_94e2_dee6d9e74674
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4831
initial amount: NaN
is: P22392
is: SBO:0000252
boundary condition: true
name: NME2
has only substance units: false

metaM 2hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: 2,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM lgnc c
name: lignocerate
is: SBO:0000247
is: CHEBI:31014
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
boundary condition: false
is: HMDB02003

metaM pristanal c
type: Species
has only substance units: false
is: HMDB01958
constant: false
is: CHEBI:49189
name: pristanal
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
is: SBO:0000247
initial concentration: 1.0

metaM udpgal g
name: UDP-D-galactose(2-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
type: Species
is: HMDB00302
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58439

http://identifiers.org/biomodels.db/MODEL1310110038#_cccdad74_9698_49fa_a618_0b37f3f0d7c5
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: Q9NYW8
is encoded by: hsa:57786
name: RBAK
initial amount: NaN
boundary condition: true
has only substance units: false

metaR TYMSULT
is described by: ECO:0000269
modifier: MODEL1310110038#
name: Tyramine Sulfotransferase
type: Reaction
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: false
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1

metaR r0249
reversible: true
product: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.7.12

metaR THD1m
is described by: ECO:0000269
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
reversible: true
modifier: MODEL1310110038#
name: NAD(P) transhydrogenase
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.1.2

http://identifiers.org/biomodels.db/MODEL1310110038#_af96705b_5a85_41ba_987f_430809a75119
is encoded by: hsa:55825
is: SBO:0000252
is: Q9BY49
has only substance units: false
constant: false
initial concentration: NaN
name: PECR
boundary condition: true
type: Species
initial amount: NaN

metaR S4TASE4ly
reactant: MODEL1310110038#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110038#
fast: false
is: SBO:0000176

metaM kynate c
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00715
is: CHEBI:58454
constant: false
name: kynurenate
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
has only substance units: false
initial concentration: 1.0

metaM acmana r
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: N-acetyl-D-mannosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
is: CHEBI:17122
has only substance units: false
is: HMDB01129

metaR XYLTt
name: Xylitol transport via passive diffusion
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110038#
reversible: true

metaR 3SALATAim
kinetic law: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
fast: false
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
reversible: false
product: MODEL1310110038#

metaR SERDGLNexR
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
name: D-Serine/Glutamine reversible exchange
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_69f2c599_a219_43b6_83b0_9f0acfa77ab8
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: NME1
is encoded by: hsa:4830
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_dc7ef0e5_ef83_4df1_ab40_329e6992eae1
constant: false
has only substance units: false
is encoded by: hsa:10164
is: SBO:0000252
type: Species
boundary condition: true
is: Q8NCG5
name: CHST4
initial amount: NaN
initial concentration: NaN

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
is: SBO:0000247
is: C00130
initial amount: NaN
is: CHEBI:58053
has only substance units: false
is: HMDB00175
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6

metaR RE3556C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110038#
name: RE3556
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
fast: false

metaR MACACI
type: Reaction
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000269
name: maleylacetoacetate isomerase
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.5.1.18

metaR r0472
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110038#
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110038#_7f0550fc_40b6_4ebc_944f_c63b5906a528
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:4728
is: O00217
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: NDUFS8

metaR DADNt4
name: deoxyadenosine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
reactant: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110038#
fast: false

metaR STRDNCt
product: MODEL1310110038#
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

metaR RE1447M
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
fast: false
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#

metaM thyox L e
has only substance units: false
name: L-thyroxine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:18332
is: HMDB00248

metaM doco13ecoa c
has only substance units: false
name: 13-docosenoylcoa
is: http://identifiers.org/pubchem.compound/24892791
is: SBO:0000247
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_c959b96d_1116_424b_bca9_fae7fadb90e1
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: P33121
name: ACSL1
has only substance units: false
boundary condition: true
is encoded by: hsa:2180

metaM eicostetcoa c
name: eicosatetranoyl coenzyme A
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: C16164
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR DCSPTN1t
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110038#
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR r0178
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/2.5.1.21
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16

metaM Ser Thr g
boundary condition: false
is: HMDB00645
is: SBO:0000247
is: CHEBI:58336
type: Species
has only substance units: false
name: protein-linked serine or threonine residue (O-glycosylation site)
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110038#_2767ec26_17d2_43aa_9d42_3700ddb644fa
constant: false
is encoded by: hsa:84890
is: B3KXN9
initial concentration: NaN
initial amount: NaN
name: ADO
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaM lgnc e
boundary condition: false
type: Species
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02003
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC10C10OHm
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c5fa9cb9_f935_487a_ac94_7a55cf096678
boundary condition: true
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:51227
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110038#_a20d4065_f9ed_4ee3_9754_f29fd6dbbdb1
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: MAN1A2
type: Species
is: O60476
is encoded by: hsa:10905
has only substance units: false
initial concentration: NaN
constant: false

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_1c1840e7_e46f_41fa_b49b_d0e55badaab2
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: BCKDHB
has only substance units: false
is: P21953
type: Species
is encoded by: hsa:594
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_72556163_609e_4bc3_ae5c_863f91294e56
is encoded by: hsa:248
type: Species
initial amount: NaN
constant: false
is: P09923
name: ALPI
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_d846c9cb_b287_4a87_b3ef_afeb08e6d218
initial amount: NaN
type: Species
initial concentration: NaN
name: ATP1B2
has only substance units: false
is encoded by: hsa:482
is: P14415
is: SBO:0000252
boundary condition: true
constant: false

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR TREHe
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
name: alpha,alpha-trehalase
reversible: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaM chito2pdol U c
has only substance units: false
type: Species
is: CHEBI:12427
initial amount: NaN
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
initial concentration: 1.0
constant: false
boundary condition: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247

metaR r0474
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
type: Reaction
product: MODEL1310110038#

metaM HC01231 m
initial concentration: 1.0
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
has only substance units: false
is: CHEBI:58480

metaM CE2434 m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
constant: false
type: Species

metaM 10fthf5glu e
is: HMDB00972
constant: false
has only substance units: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial amount: NaN
is: CHEBI:57454
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)

metaM thyox L c
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00248
boundary condition: false
initial amount: NaN
name: L-thyroxine

metaR CYSSERNaEx
name: L-serine/L-cysteine Na-dependent exchange (Cys-L in)
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d0b467c3_ac6e_44d8_a922_f4ede1539c0f
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: AMD1
is: P17707
boundary condition: true
is: SBO:0000252
is encoded by: hsa:262
has only substance units: false

metaM ach e
has only substance units: false
name: acetylcholine
is: SBO:0000247
initial amount: NaN
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaM pan4p c
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
constant: false
is: C01134
is: HMDB01416
initial concentration: 1.0
boundary condition: false
is: CHEBI:47942
type: Species
initial amount: NaN
name: Pantetheine 4'-phosphate
is: SBO:0000247

metaR r0475
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110038#
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176

metaM vacccoa c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: vaccenyl coenzyme A
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677

metaM L2aadp m
constant: false
boundary condition: false
name: L-2-aminoadipate(1-)
initial amount: NaN
has only substance units: false
is: CHEBI:58672
is: SBO:0000247
type: Species
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
initial concentration: 1.0

metaM citr L c
is: CHEBI:16349
is: SBO:0000247
name: L-citrulline
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
initial amount: NaN

metaR PACCOAL
is described by: ECO:0000000
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
is: SBO:0000176
type: Reaction
name: phenylacetate-CoA ligase

metaR RE0512M
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction

metaM 5mta e
type: Species
notes: FORMULA: C11H15N5O3S CHARGE: 0
boundary condition: false
name: 5-Methylthioadenosine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17509
initial amount: NaN
is: C00170
is: HMDB01173
constant: false
has only substance units: false

metaR ATPH1e
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110038#
name: ATP diphosphohydrolase
type: Reaction
reversible: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM Ser Thr l
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:58190
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
notes: FORMULA: XH CHARGE: 0
is: HMDB00224
has only substance units: false
initial amount: NaN

metaR G14T3g
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110038#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#

metaR r0399
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
modifier: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_8e0af6e6_9218_47e6_830f_dfeaa9d478c6
name: ACADM
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:34
type: Species
is: P11310
is: SBO:0000252
boundary condition: true

metaR r0173
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
modifier: MODEL1310110038#
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
is described by: ECO:0000000
fast: false
reactant: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.19
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_5fd3e708_9d91_45fa_9dae_1a3ea7cbb12a
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AA788780
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: _AA788780_1_c

metaM 10fthf m
is: SBO:0000247
is: HMDB00972
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57454
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
name: 10-formyltetrahydrofolate(2-)

metaR r1106
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Postulated transport reaction

metaM 3ohdcoa m
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
constant: false
is: CHEBI:57349
is: HMDB06402
name: 3-oxopalmitoyl-CoA(4-)
type: Species

metaR LNLNCGCRNt
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110038#
type: Reaction
reversible: false
is: SBO:0000185
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_1a70d5bc_97a0_4ade_a41a_84c64e43971e
constant: false
is: SBO:0000252
name: _X63359_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:X63359
type: Species
has only substance units: false

metaM HC01522 c
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
is: CHEBI:28508
name: Gentisate aldehyde
boundary condition: false
initial amount: NaN
constant: false

metaM ach c
is: SBO:0000247
boundary condition: false
is: CHEBI:15355
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
is: HMDB00895
initial concentration: 1.0

metaR r1773
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110038#

metaM cholp g
is: SBO:0000247
is: CHEBI:295975
constant: false
name: choline phosphate(1-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
boundary condition: false
type: Species
is: C00588

http://identifiers.org/biomodels.db/MODEL1310110038#_7efd1c48_5153_46cd_a371_a1f73d45f403
is: Q7LG56
is: SBO:0000252
initial amount: NaN
type: Species
name: RRM2B
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:50484

metaM HC01399 m
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: (S)-3-Hydroxytetradecanoyl-CoA
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: CHEBI:27466

metaR C12DCACT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaR GALK
is version of: http://identifiers.org/ec-code/2.7.1.6
fast: false
product: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
name: galactokinase
is version of: http://identifiers.org/ec-code/2.7.1.157
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_fb3cee14_a169_48cd_af20_4aff70e70a10
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: _AL048840_1_c
has only substance units: false
type: Species
is encoded by: hsa:AL048840

metaR EX 3hexdcrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_79b55add_b304_42c5_8d29_5088e0c5059f
boundary condition: true
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
is: SBO:0000297
initial concentration: NaN
type: Species
name: NME1:NME2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_81f05704_e143_4676_ab3d_404095440136
name: CBR1
is: SBO:0000252
is: P16152
has only substance units: false
initial amount: NaN
is encoded by: hsa:873
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM arg L e
has only substance units: false
name: L-argininium(1+)
is: SBO:0000247
is: CHEBI:32682
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
type: Species
constant: false
initial concentration: 1.0

metaM pan4p e
type: Species
is: HMDB01416
is: SBO:0000247
name: Pantetheine 4'-phosphate
is: CHEBI:47942
constant: false
initial concentration: 1.0
is: C01134
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM xan c
is: SBO:0000247
initial concentration: 1.0
name: Xanthine
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: HMDB00292
type: Species
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: C00385

http://identifiers.org/biomodels.db/MODEL1310110038#_b26cc796_8df7_4465_9493_36fdb2e00284
constant: false
type: Species
is: Q59F77
is encoded by: hsa:5330
has only substance units: false
name: PLCB2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_72fb0909_9095_4da9_9521_f218f14df475
name: CA14
is encoded by: hsa:23632
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: A8K3J4
is: SBO:0000252

metaR GLCMter
is: SBO:0000185
product: MODEL1310110038#
is described by: ECO:0000000
reversible: false
type: Reaction
name: glucose transport via membrane vesicle
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
fast: false
reactant: MODEL1310110038#

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_4e3ac336_54c4_4380_b322_a1c867e2e704
initial concentration: NaN
is encoded by: hsa:686
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: P43251
name: BTD
type: Species

metaR MG1er
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.106
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_59cbd809_6ee7_4e7e_b383_a33ddb5ee060
constant: false
initial amount: NaN
name: PKM2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:5315

http://identifiers.org/biomodels.db/MODEL1310110038#_dbf42c97_7dd4_46df_8d57_0746f1e2aa6f
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: HADH
has only substance units: false
is: Q16836
is encoded by: hsa:3033

metaR FAOXC226m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR FAOXC4C4DCc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_e448e91f_2021_4e3d_9c93_9a4006aa0fa7
type: Species
initial amount: NaN
boundary condition: true
name: HEPH
is encoded by: hsa:9843
is: E9PHN8
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c27c73bb_ec15_4641_b1af_934db4591679
has only substance units: false
boundary condition: true
name: SLC35D2
is: Q76EJ3
constant: false
initial concentration: NaN
is encoded by: hsa:11046
is: SBO:0000252
initial amount: NaN
type: Species

metaR G14T5g
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110038#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
reversible: false

metaM dhap e
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
type: Species
name: glycerone phosphate(2-)
boundary condition: false
is: SBO:0000247
is: HMDB01473
has only substance units: false
initial amount: NaN
is: CHEBI:57642
constant: false

metaR ABTArm
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
name: 4-aminobutyrate transaminase, reversible (mitochondrial)

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_77bc71fe_8f42_48ba_89c5_c1434ee224c5
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:80308
has only substance units: false
name: FLAD1
is: SBO:0000252
boundary condition: true

metaR PROSTGE2t2
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
name: prostaglandin uniport
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

metaR ALAGLYexR
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
name: L-alanine/glycine reversible exchange
kinetic law: MODEL1310110038#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
reversible: true

metaM CE5236 n
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
initial amount: NaN
constant: false
is: CHEBI:28002
is: HMDB03952
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR PSSA1 hs
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.8.29
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110038#
type: Reaction
name: Phosphatidylserine synthase homo sapiens

metaR ESTRADIOLt
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110038#
name: estradiol transport
is: SBO:0000185
reversible: true

metaM 25aics c
has only substance units: false
is: CHEBI:58443
is: C04823
is: HMDB00797
boundary condition: false
type: Species
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
initial amount: NaN
is: SBO:0000247
constant: false
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial concentration: 1.0

metaM gthrd m
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
is: HMDB00125
name: glutathionate(1-)
is: CHEBI:57925
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaM 42A3HP24DB c
initial amount: NaN
is: HMDB04083
constant: false
boundary condition: false
is: SBO:0000247
is: C05645
initial concentration: 1.0
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
type: Species
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: http://identifiers.org/pubchem.compound/7956
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_791a5467_a2fd_4250_b438_cf6cd410aa3e
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is: O14556
name: GAPDHS
is encoded by: hsa:26330
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM dhap c
initial amount: NaN
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
is: C00111
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: Dihydroxyacetone phosphate
has only substance units: false
is: SBO:0000247
is: HMDB01473

metaR FAOXC221C201x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_dcaf7cfd_1827_4d03_ad8a_ad7646c5183f
initial amount: NaN
constant: false
is: SBO:0000252
name: ME2
initial concentration: NaN
is: P23368
has only substance units: false
is encoded by: hsa:4200
boundary condition: true
type: Species

metaM 13dpg c
constant: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: C00236
name: 3-Phospho-D-glyceroyl phosphate
is: http://identifiers.org/pubchem.compound/3535
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:57604
is: HMDB01270
initial concentration: 1.0
type: Species

metaR DCTPtn
fast: false
type: Reaction
name: dCTP diffusion in nucleus
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#
reversible: true

metaM thymd e
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
initial concentration: 1.0
is: CHEBI:17748
is: HMDB00273
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: C00214
name: Thymidine
is: SBO:0000247
constant: false

W3 CDTF: Wed Aug 29 22:29:58 BST 2012

metaR OCD11COACPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR CRNt
is described by: ECO:0000269
kinetic law: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
name: L-carnitine reversible transport
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110038#
type: Reaction

metaR r2198
reversible: true
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM prgnlone m
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
is: CHEBI:16581
boundary condition: false
is: SBO:0000247
constant: false
name: pregnenolone
initial amount: NaN
initial concentration: 1.0
is: HMDB00253
type: Species
has only substance units: false

metaM 3mob c
has only substance units: false
type: Species
is: CHEBI:11851
initial amount: NaN
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
is: HMDB00019
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

metaR ASNNm
is described by: ECO:0000254
reversible: false
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
is version of: http://identifiers.org/ec-code/3.5.1.1
modifier: MODEL1310110038#
name: L-asparaginase (mitochondrial)
is: SBO:0000176
type: Reaction

metaR r0683
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
modifier: MODEL1310110038#
product: MODEL1310110038#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110038#_1a0b393b_a212_4c72_b85a_69b687435826
boundary condition: true
type: Species
is encoded by: hsa:4702
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: NDUFA8
constant: false
initial amount: NaN
is: B1AM93

metaM HC01401 m
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
is: CHEBI:27668
boundary condition: false
constant: false
type: Species
has only substance units: false
is: SBO:0000247

metaR r1567
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR THRSERNaEx
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
is: SBO:0000185
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110038#
fast: false
name: L-serine/L-threonine Na-dependent exchange (Thr-L in)
kinetic law: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#

metaR ILEtec
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
type: Reaction
name: L-isoleucine transport via diffusion (extracellular to cytosol)
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_39207572_78c7_4109_a24e_a3e6a54f5b56
constant: false
is: SBO:0000252
name: RDH14
has only substance units: false
is: Q9HBH5
initial amount: NaN
boundary condition: true
is encoded by: hsa:57665
type: Species
initial concentration: NaN

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM dadp c
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: SBO:0000247
name: dADP
constant: false
is: C00206
has only substance units: false
boundary condition: false
is: CHEBI:57667
initial concentration: 1.0
is: HMDB01508
initial amount: NaN

metaM 3aib e
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB02166
name: (S)-3-aminoisobutyric acid
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:33094
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_ad598628_ff3c_4d46_8d84_647efde99939
initial concentration: NaN
is encoded by: hsa:3283
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: HSD3B1
type: Species
is: P14060
boundary condition: true

metaR r2197
kinetic law: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_e1c374a8_d9f6_4826_b61e_b2d19f446373
type: Species
has only substance units: false
name: PRODH2
constant: false
is: SBO:0000252
is encoded by: hsa:58510
boundary condition: true
initial amount: NaN
is: Q9UF12
initial concentration: NaN

metaM tdchola e
initial amount: NaN
name: taurochenodeoxycholate
boundary condition: false
type: Species
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
constant: false
is: HMDB00951
has only substance units: false
is: CHEBI:9407
initial concentration: 1.0

metaM thp2c x
name: 1-piperideine-6-carboxylate
has only substance units: false
is: CHEBI:16987
is: HMDB12130
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false

metaM xol27oh m
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
has only substance units: false
is: CHEBI:17703
initial amount: NaN
name: 26-hydroxycholesterol
type: Species

metaR ENGASE3ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110038#
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false

metaR r1568
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

metaR TCYNTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#

W3 CDTF: Wed Aug 29 22:29:57 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110038#_262dbea0_71f3_4ebb_996e_944b9ab8c022
constant: false
is: Q5BKT4
name: ALG10
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:84920
is: SBO:0000252

metaR r2196
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaM val L e
has only substance units: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
name: L-valine
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00883
initial amount: NaN

metaM thf c
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
is: C00101
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
is: CHEBI:57453
has only substance units: false

metaR LEUTAm
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
name: leucine transaminase, mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110038#
is described by: ECO:0000269
fast: false

metaM 3ivcoa m
type: Species
is: C05998
has only substance units: false
constant: false
name: 3-hydroxyisovalerylcoa
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_4dcee0e0_aba0_40ad_be2d_f9284a62e7ae
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4905
is: P46459
name: NSF
is: SBO:0000252
constant: false

metaR r1975
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
is: SBO:0000185
type: Reaction

metaM m3mpdol U c
type: Species
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
initial amount: NaN
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
is: CHEBI:37632
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a6870fb8_3fe6_4bfb_be8c_ac1584586817
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: OXCT1
has only substance units: false
is encoded by: hsa:5019
initial concentration: NaN
is: P55809

metaR C101CRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_581bfdf1_0817_4da4_8105_90791ff90280
name: HMGCLL1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54511
is: Q9NT06
constant: false
type: Species
initial amount: NaN
boundary condition: true

metaR r1569
product: MODEL1310110038#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM CE0785 m
name: cis,cis-myristo-5,8-dienoyl-CoA
is: CHEBI:57795
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785

metaM ksii core2 deg5 l
initial amount: NaN
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
is: HMDB00143
type: Species
constant: false
boundary condition: false
notes: FORMULA: C50H82N4O38SX CHARGE: -1
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 5

metaM 3aib c
constant: false
is: CHEBI:33094
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
name: (S)-3-aminoisobutyric acid
boundary condition: false
initial concentration: 1.0
is: HMDB02166
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

W3 CDTF: Wed Aug 29 22:29:58 BST 2012

metaM 4hexdtricoa m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 4,7,10-hexadecatrienoylcoa
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02288
type: Species

metaR r2195
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaR FAOXTC142TC122m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaM 3mob e
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
type: Species
is: CHEBI:11851
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00019
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_503d7cd8_d93e_48e9_93a6_5261337bc834
constant: false
has only substance units: false
is encoded by: hsa:47
name: ACLY
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_0bc6f2b4_c73d_49b8_82a2_00e829c028bc
is encoded by: hsa:4696
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFA3
initial amount: NaN
boundary condition: true
is: O95167
constant: false

metaM tdchola c
name: taurochenodeoxycholate
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00951
initial concentration: 1.0
is: CHEBI:9407

metaM ksi deg36 l
name: keratan sulfate I, degradation product 36
has only substance units: false
type: Species
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:12936
is: HMDB00143
boundary condition: false

metaR r0680
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110038#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaM uacgam r
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57705
constant: false
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e5c53e2a_5915_4dcc_95df_323cdea7b62c
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:56301
is: SBO:0000252
initial concentration: NaN
is: Q9NS82
name: SLC7A10

metaR r1624
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110038#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110038#

metaM prostgf2 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin F2alpha(1-)
type: Species
constant: false
has only substance units: false
is: CHEBI:57404
is: HMDB01139

http://identifiers.org/biomodels.db/MODEL1310110038#_5d2bcab4_1642_43e1_8d7b_a22b9aa59969
name: DPAGT1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1798
is: Q9H3H5
initial concentration: NaN

metaM dudp m
type: Species
is: HMDB01000
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: dUDP(3-)
is: CHEBI:60471

metaR r1563
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_1c0cbc7c_8494_452c_b4c9_5e72849ca7a0
name: _NM_013421_1_m
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:NM 013421
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_bf6fe6e2_2b73_46ab_ba22_1901fca5ae9e
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6561
initial amount: NaN
name: SLC13A1
is: Q9BZW2
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9b3007a6_e8fc_4b3d_addf_c66f6681b1d1
type: Species
initial amount: NaN
is: Q6IBC4
is encoded by: hsa:4726
name: NDUFS6
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR ALR2
modifier: MODEL1310110038#
is: SBO:0000176
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
name: aldose reductase (methylglyoxal)
kinetic law: MODEL1310110038#

metaR r2089
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#

metaM val L c
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
initial concentration: 1.0
name: L-valine
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16414
constant: false
is: HMDB00883

metaR EHGLATm
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110038#
is described by: ECO:0000212
reversible: false
is: SBO:0000176
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110038#
fast: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_915b9463_d4b8_4c7f_b6eb_e4bf99651085
name: DPAGT1
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1798
constant: false
type: Species
initial concentration: NaN

metaR NACHEXA16ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110038#
fast: false
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d9fccc73_1591_4f92_95d6_b8100a01efad
is encoded by: hsa:481
is encoded by: hsa:478
has part: B7Z2T0
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has only substance units: false
constant: false
name: ATP1A3:ATP1B1
initial amount: NaN
has part: A3KLL5
type: Species

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM aacoa c
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01484
is: C00332
boundary condition: false
name: Acetoacetyl-CoA
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_7c456a60_6eef_498c_9993_d9d40fff3086
is encoded by: hsa:5373
boundary condition: true
is: SBO:0000252
constant: false
name: PMM2
type: Species
has only substance units: false
is: O15305
initial concentration: NaN
initial amount: NaN

metaM r1p c
is: CHEBI:57720
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01489
boundary condition: false
is: C00442
constant: false
initial concentration: 1.0
has only substance units: false
name: alpha-D-Ribose 1-phosphate

metaR XANDp
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
name: xanthine dehydrogenase, peroxisomal
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Purine catabolism EC Number: 1.1.1.204 Confidence Level: 4 AUTHORS: PMID:12637268,PMID:8670112 NOTES:Acts on a variety of purines and aldehydes. The animal enzyme can be interconverted to EC 1.1.3.22 xanthine oxidase (the oxidase form). IT
kinetic law: MODEL1310110038#
reversible: false
fast: false
is described by: ECO:0000269

metaR r1564
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
fast: false

metaR r0686
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
modifier: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true

metaR CYSGLTH
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reversible: true
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: Glutathione:cystine oxidoreductase
reactant: MODEL1310110038#

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
initial amount: NaN
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_53535e2c_ccd7_43b9_95cb_356575dc5d7e
is: B4DX94
name: PGM3
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:5238
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b00b3dec_3893_4bc0_af85_be74948ab966
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA278423
name: _AA278423_1_c

metaR r2088
is: SBO:0000185
fast: false
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_22ee95fd_79e2_4720_86c8_7ab535da3f19
name: HADHB
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3032
has only substance units: false
is: P55084
initial concentration: NaN

metaR r1625
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000

metaR RTOTALt
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
name: RTOTAL transport
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_579fa47e_6b7a_49e2_a6ea_0769a55d13b0
initial concentration: NaN
boundary condition: true
is: A6H8L5
is encoded by: hsa:3990
initial amount: NaN
name: LIPC
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM gthrd c
is: HMDB00125
is: C00051
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
name: Reduced glutathione
boundary condition: false
type: Species

metaM cspg b e
type: Species
boundary condition: false
is: C00106
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: CHEBI:17568
initial amount: NaN
is: SBO:0000247
is: HMDB00300
has only substance units: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
constant: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR r1565
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_33dfde92_03d6_4a14_9762_2b5df988c8fe
has only substance units: false
is encoded by: hsa:2592
name: GALT
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: E7ET32

metaR ABTD
type: Reaction
fast: false
reversible: true
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
name: L-arabinitol 4-dehydrogenase

metaR RETI1
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: retinol isomerase (11-cis)
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_a378f2ca_dae4_4d93_aa02_b95cb49a3ce1
is: Q96E98
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6005
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: RHAG
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_4b18ff73_dc33_4171_8952_80c6a4bd34f1
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: _AI926493_1_m
is encoded by: hsa:AI926493
has only substance units: false
initial amount: NaN
boundary condition: true

metaR NACASPAH
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.15
modifier: MODEL1310110038#
name: N-Acetyl-L-aspartate amidohydrolase
reversible: false
fast: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
kinetic law: MODEL1310110038#
is: SBO:0000176

metaM 3hbcoa m
initial amount: NaN
is: CHEBI:57316
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
name: (S)-3-hydroxybutanoyl-CoA(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6b2b8273_4afe_4dc4_a080_056e50de4ee7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: F8W682
boundary condition: true
initial amount: NaN
is encoded by: hsa:6522
name: SLC4A2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_74920520_3ada_4bbd_915e_717ffaacc702
initial concentration: NaN
has only substance units: false
name: CTPS2
constant: false
type: Species
is encoded by: hsa:56474
is: Q9NRF8
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR r2087
type: Reaction
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110038#_23e756d7_f3c9_4a9c_921f_2b1bbe6b320a
is: O60488
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: ACSL4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2182
constant: false

metaM dnad c
is: C00857
is: CHEBI:18304
is: HMDB01179
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Deamino-NAD+
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: SBO:0000247

metaR r1626
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true

metaR HEXDCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

metaR AG13T9g
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
type: Reaction

metaR r1566
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM fdp c
name: D-Fructose 1,6-bisphosphate
is: HMDB01058
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
initial amount: NaN
is: CHEBI:16905
is: C00354
is: http://identifiers.org/pubchem.compound/3647
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM core3 g
name: Core 3
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16250
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H27N2O10X CHARGE: 0
type: Species

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR IZPN
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: Imidazolonepropionase
product: MODEL1310110038#
reactant: MODEL1310110038#

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR ALR3
reversible: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110038#
is described by: ECO:0000269
name: aldose reductase (acetol)
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false

metaR r2086
product: MODEL1310110038#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true

metaM gthrd e
name: glutathionate(1-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
is: HMDB00125
has only substance units: false

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110038#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
name: RE1527
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110038#

metaR r1627
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_e9f978ac_5b67_4517_9cbd_c2da1dda1421
is encoded by: hsa:38
name: ACAT1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P24752
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_ebd0094b_76c3_4814_9a5c_9fa2fd74f21a
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:6487
initial concentration: NaN
type: Species
has only substance units: false
name: ST3GAL3
initial amount: NaN

metaR GCHOLAtx
kinetic law: MODEL1310110038#
name: bile acid intracellular transport
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reversible: true
product: MODEL1310110038#

metaM 4hexdtricoa x
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
constant: false

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:57667
initial amount: NaN
is: HMDB01508
name: dADP(3-)

metaR BUTt2r
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
name: Butyrate transport via proton symport, reversible
is described by: ECO:0000269
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR

metaM glyc3p x
initial amount: NaN
name: Glycerol 3-phosphate
boundary condition: false
constant: false
is: C00093
is: CHEBI:57597
is: SBO:0000247
has only substance units: false
is: HMDB00126
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093

metaM thf m
initial amount: NaN
type: Species
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
is: HMDB01846
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_8aae4daf_955e_4714_89ce_4dcc5b89209f
name: AHCYL1
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10768
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r1628
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
type: Reaction
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

metaM l2n2m2mn l
constant: false
type: Species
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: CHEBI:12936
is: HMDB00143
has only substance units: false
initial amount: NaN

metaM adpcoa x
is: C14143
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
has only substance units: false
is: SBO:0000247
name: adipoylcoa
is: HMDB04047

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_471b7f94_0d38_48a9_9047_9e8521ad7a25
name: _AI285872_1_c
is: SBO:0000252
is encoded by: hsa:AI285872
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM phe L c
is: SBO:0000247
name: L-phenylalanine
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
is: CHEBI:17295
initial amount: NaN
type: Species
is: HMDB00159
constant: false
boundary condition: false

metaR ADK3
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reversible: true
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110038#
type: Reaction
fast: false
name: adentylate kinase (GTP)

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
reversible: true

metaR FAOXTC162TC142m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaM orot e
boundary condition: false
is: CHEBI:30839
type: Species
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: SBO:0000247
initial concentration: 1.0
is: HMDB00226
constant: false
name: orotate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_d7e3a74c_b4ae_4cb8_910c_fb35ef936d91
name: NDUFA3
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4696
initial amount: NaN
is: O95167
type: Species
constant: false
is: SBO:0000252

metaR MI134PP
reversible: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.57
type: Reaction
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 1-phosphatase
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_0de26b73_672f_4a7c_851b_940ed3598913
is: SBO:0000252
is: P05091
boundary condition: true
is encoded by: hsa:217
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ALDH2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9a555aac_b562_4ab7_ab10_a07d566db250
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: PCBD2
has only substance units: false
type: Species
is: Q9H0N5
is encoded by: hsa:84105

http://identifiers.org/biomodels.db/MODEL1310110038#_ffa55dea_5a03_43ce_9dad_3982ef9563c5
type: Species
constant: false
is encoded by: hsa:11041
boundary condition: true
initial amount: NaN
name: B3GNT1
is: O43505
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
fast: false
type: Reaction
product: MODEL1310110038#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_6f67552f_83df_4e12_a55d_bae2e566f90f
is encoded by: hsa:763
name: CA5A
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: P35218
boundary condition: true
constant: false
initial amount: NaN

metaM frdp c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00448
constant: false
initial concentration: 1.0
is: CHEBI:175763
is: HMDB00961
name: Farnesyl diphosphate
type: Species
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaM tymsf e
boundary condition: false
type: Species
constant: false
name: Tyramine O-sulfate
is: HMDB06409
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN

metaM subeac x
initial concentration: 1.0
name: suberic acid
is: HMDB00893
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C8H12O4 CHARGE: -2
initial amount: NaN

metaM CE5236 c
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: CHEBI:28002
initial amount: NaN
is: SBO:0000247
is: HMDB03952
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_d2b9f62a_b1b3_4a2d_a44f_831a5b016356
has only substance units: false
is: Q11203
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
constant: false
name: ST3GAL3
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r1561
reactant: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110038#
is: SBO:0000185
fast: false

metaM phe L e
is: HMDB00159
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
boundary condition: false
name: L-phenylalanine
is: SBO:0000247
is: CHEBI:17295
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e2bc0144_c557_466c_9566_bc600116974e
initial concentration: NaN
is: O75387
initial amount: NaN
name: SLC43A1
is encoded by: hsa:8501
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM prostgf2 c
is: HMDB01139
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57404

metaM xol27oh r
is: SBO:0000247
type: Species
name: 26-hydroxycholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17703
is: HMDB02103

metaR NACHEX25ly
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal

metaR ALAR
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110038#
is described by: ECO:0000212
name: alanine racemase
fast: false
product: MODEL1310110038#

metaR LCTStg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
is: SBO:0000185
name: lactose transport from Golgi to extracellular (via vesicle)
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_9873701a_180b_4fb4_96db_d1c1bbf3a50e
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AF116616_1_m
is encoded by: hsa:AF116616
is: SBO:0000252

metaR MTHFD2m
is described by: ECO:0000254
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reactant: MODEL1310110038#
reversible: true
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110038#
is: SBO:0000176

metaR DMHPTCRNt
reactant: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: 2,6 dimethylheptanoyl crn transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_c2f80791_2df9_43e9_836d_6e8d49dbce1e
type: Species
is encoded by: hsa:8789
has only substance units: false
constant: false
initial amount: NaN
is: O00757
name: FBP2
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_1f23fecc_acae_483e_96d2_ba84d0b89615
is encoded by: hsa:1103
constant: false
is: SBO:0000252
is: P28329
initial amount: NaN
boundary condition: true
name: CHAT
type: Species
initial concentration: NaN
has only substance units: false

metaR FAOXC2051843m
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: Beta oxidation of fatty acid
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110038#_866e7050_1a77_450b_8469_d0c479610cf2
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: NDUFA8
is: SBO:0000252
is encoded by: hsa:4702
is: B1AM93
boundary condition: true

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR DALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
type: Reaction
name: D-alanine transport via proton symport
is described by: ECO:0000304
reactant: MODEL1310110038#
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_bfc5b44c_b7c2_458a_89cc_c7673e7c3a11
has only substance units: false
boundary condition: true
is encoded by: hsa:2181
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: O95573
name: ACSL3

metaR GLNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
name: L-glutamine transport via electroneutral transporter
reversible: false
fast: false
is: SBO:0000185

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: SBO:0000176
fast: false
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
kinetic law: MODEL1310110038#

metaM tre e
name: Trehalose
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: C01083
has only substance units: false
type: Species
is: CHEBI:16551
is: HMDB00975

metaM dudp n
is: SBO:0000247
is: CHEBI:60471
constant: false
has only substance units: false
is: HMDB01000
name: dUDP(3-)
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_bc1c4645_026e_4779_a247_807e8e91db2f
name: UPB1
initial amount: NaN
is encoded by: hsa:51733
has only substance units: false
is: B3KNC1
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaR 4NPHte
fast: false
reversible: true
reactant: MODEL1310110038#
name: xenobiotic transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_a8b29e05_b91c_4791_8e27_5b01f80c6a2c
name: SDHA
has only substance units: false
initial concentration: NaN
is: P31040
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6389

metaM orot c
is: HMDB00226
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:30839
type: Species
name: Orotate
is: C00295
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false

metaM cspg b l
has only substance units: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02183
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
constant: false
is: CHEBI:36005

metaR BILIRUBtr
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#

metaR THRASNNaEx
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
name: L-threonine/L-asparagine Na-dependent exchange (Thr-L in)
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaM 3mob m
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:11851
is: HMDB00019
boundary condition: false
type: Species
name: 3-methyl-2-oxobutanoate
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247

metaM tymsf c
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
name: Tyramine O-sulfate
constant: false
is: HMDB06409
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
is: SBO:0000247

metaM c10dc x
boundary condition: false
is: HMDB13325
initial amount: NaN
notes: FORMULA: C17H30NO6 CHARGE: -1
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
name: sebacoyl carnitine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0530c9e9_167e_4cda_b67b_32e679792cb1
is encoded by: hsa:28976
is: Q9H845
name: ACAD9
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaM for e
is: HMDB00142
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15740
name: formate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false

metaM dlnlcgcoa m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27979
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
name: dihomo-gamma-linolenyl coenzyme A

metaM gmp g
name: GMP(3-)
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
is: HMDB01397
boundary condition: false
is: CHEBI:58115
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaR r0181
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
fast: false
reversible: true
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000

metaM 5dpmev x
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: (R)-5-Diphosphomevalonate
has only substance units: false
is: CHEBI:15899
is: HMDB01090
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
type: Species
boundary condition: false

metaR RE1836X
name: RE1836
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: true
fast: false
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:

metaM etoh e
boundary condition: false
name: ethanol
is: SBO:0000247
is: CHEBI:16236
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00108
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469

metaR r2091
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
product: MODEL1310110038#
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR ACNAMlt
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
name: N-acetylneuraminate transport into lysososme
kinetic law: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction

metaR r2093
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110038#

metaR BAMPPALDOX
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
product: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
kinetic law: MODEL1310110038#
is described by: ECO:0000212
is: SBO:0000176

metaR SCP21x
product: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
modifier: MODEL1310110038#
name: Sterol carrier protein 2
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185

metaR 5MTAte
reversible: true
is: SBO:0000185
is described by: ECO:0000134
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
name: Transport of 5-S-methyl-5-thioadenosine

http://identifiers.org/biomodels.db/MODEL1310110038#_8686d766_fbf3_4b66_b14e_78023fa80c4e
boundary condition: true
is encoded by: hsa:H77542
constant: false
type: Species
name: _H77542_1_c
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r2092
reactant: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110038#
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_f5b93f7f_c97f_4cc2_a179_b7c163743fab
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: HMGCS1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3157

metaM gacpail hs r
initial amount: NaN
name: glucosaminyl-acylphosphatidylinositol
boundary condition: false
initial concentration: 1.0
is: HMDB01401
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: C00092
constant: false
has only substance units: false
is: SBO:0000247

metaR FAOXC123m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d488abe6_a1eb_4c3c_828e_a6bf985aff91
type: Species
is: SBO:0000252
is: Q9Y2C5
boundary condition: true
constant: false
initial concentration: NaN
name: SLC17A4
initial amount: NaN
has only substance units: false
is encoded by: hsa:10050

http://identifiers.org/biomodels.db/MODEL1310110038#_30811098_16b5_455d_8668_a84c3f55b568
is: SBO:0000252
initial concentration: NaN
is: Q6ZMR3
type: Species
name: LDHAL6A
is encoded by: hsa:160287
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM pa hs c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN
is: CHEBI:57739
name: phosphatidate(2-)
constant: false
boundary condition: false
type: Species

metaR PItx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
name: Phosphate transporter, peroxisome
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
fast: false

metaR TALA
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2

metaR r1631
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM dadp n
has only substance units: false
boundary condition: false
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57667
constant: false
initial amount: NaN
is: HMDB01508

http://identifiers.org/biomodels.db/MODEL1310110038#_9b2e4734_bd25_4307_8f4e_6b6db7d8a203
initial amount: NaN
constant: false
name: SLC6A6
is encoded by: hsa:6533
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9BRI2
type: Species
initial concentration: NaN

metaR DOLMANP Uter
reactant: MODEL1310110038#
product: MODEL1310110038#
name: dolichol-phosphate mannose flippase (uterus)
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reversible: false

metaM CE5126 x
type: Species
name: (2R)-pristanoyl-CoA
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:12947
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126

metaM uacgam g
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57705
is: HMDB00290

metaM 34dhoxmand c
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:27637
is: HMDB01866
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false

metaR r0926
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
type: Reaction
fast: false
product: MODEL1310110038#
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110038#

metaM dudp c
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
is: C01346
initial concentration: 1.0
is: HMDB01000
initial amount: NaN
is: CHEBI:60471
constant: false
is: SBO:0000247
name: dUDP
type: Species
boundary condition: false

metaR r0801
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185

metaR S6T9g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110038#

metaR CSPG Btly
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate B transport, extracellular to lysosome
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000

metaR 2DR1PP
reactant: MODEL1310110038#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: false
is described by: ECO:0000000

metaM 4ppan c
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
name: D-4'-Phosphopantothenate
initial concentration: 1.0
initial amount: NaN
type: Species
is: C03492
has only substance units: false
is: CHEBI:10986
is: SBO:0000247
boundary condition: false

metaM thp2c c
is: CHEBI:16987
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
initial concentration: 1.0
type: Species
is: HMDB12130
name: 1-piperideine-6-carboxylate
has only substance units: false

metaR GCHOLAte
name: bile acid intracellular transport
fast: false
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110038#
reversible: true
is: SBO:0000185

metaR GGT6
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
product: MODEL1310110038#
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_23e5c2e0_c38b_4e51_a781_368c4a45232b
type: Species
is encoded by: hsa:4723
is: E5KNH5
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: NDUFV1
boundary condition: true
has only substance units: false

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_6c1620d7_b545_46c8_820a_0a04abc5d9d9
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q92535
is: SBO:0000252
initial concentration: NaN
name: PIGC
is encoded by: hsa:5279
constant: false
type: Species

metaR CLOHtex2
kinetic law: MODEL1310110038#
name: chloride transport via hydroxide countertransport (2:1)
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110038#
is described by: ECO:0000304
reactant: MODEL1310110038#
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110038#
fast: false

metaM btn c
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
is: CHEBI:3420
name: Biotin
is: SBO:0000247
is: HMDB00030
constant: false
initial amount: NaN
type: Species

metaR r1630
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
fast: false

metaR r2090
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reversible: true
is: SBO:0000185
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
fast: false

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM dmnoncoa x
is: HMDB11604
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
name: 4,8 dimethylnonanoyl-CoA
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_8d60ae52_4947_4083_90d7_5270d605d566
is: SBO:0000252
type: Species
is encoded by: hsa:5336
initial concentration: NaN
initial amount: NaN
name: PLCG2
has only substance units: false
boundary condition: true
is: P16885
constant: false

metaR r2096
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_fec906b1_53b5_45a1_9cc5_c25eb9c2b5a7
is encoded by: hsa:2954
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: O43708
initial amount: NaN
name: GSTZ1
type: Species

metaR NDPK9n
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
type: Reaction
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is described by: ECO:0000269

metaR GGH 6THFe
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6THF), extracellular
type: Reaction

metaM ksi pre23 g
is: SBO:0000247
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 23
has only substance units: false
is: CHEBI:28067
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaM 3mop c
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00491
is: CHEBI:28654
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_ea9d780e_aae4_4a55_b3d7_19fc1e382740
boundary condition: true
initial concentration: NaN
name: DGKE
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: A1L4Q0
has only substance units: false
is encoded by: hsa:8526

metaM tcynt c
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
initial concentration: 1.0
type: Species
name: thiocyanate
initial amount: NaN
is: CHEBI:18022

metaR r1633
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM paps c
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
boundary condition: false
initial amount: NaN
is: HMDB01134
constant: false

metaR Ser Thrtg
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
name: Ser/Thr transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_72a1e995_df1c_4ebf_9537_86feb495f63f
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:7084
name: TK2
is: O00142
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR 3HBCDm
fast: false
modifier: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
reversible: true
is: SBO:0000176
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
kinetic law: MODEL1310110038#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity

metaM mthgxl c
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01167
has only substance units: false
name: methylglyoxal
is: CHEBI:17158
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_994ea40a_207b_4ec1_bb68_f9c0f499c3f4
boundary condition: true
name: ATP5H
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10476
constant: false
is: A0PJH2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_2aeb7216_59b2_4e03_ab2b_b4c762e45407
initial concentration: NaN
name: PRODH
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:5625
is: O43272

metaR PYDXNK
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110038#
name: pyridoxine kinase
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.35

metaR DOLPH Uer
reversible: false
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is described by: ECO:0000000
name: Dolichol-phosphate phosphohydrolase, human (uterus)

metaR r2097
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110038#

metaM CE2418 m
is: CHEBI:28387
initial amount: NaN
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
is: HMDB11123
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
boundary condition: false

metaM ksi deg29 l
has only substance units: false
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: keratan sulfate I, degradation product 29
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_741e35b7_f500_43fa_8bd4_48d51d96db43
is encoded by: hsa:270
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: AMPD1
type: Species
is: P23109
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_e3b33d73_e3cb_43a5_83cc_fff7b2f14309
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR r1632
reversible: true
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_8e0b5398_f31e_4f97_b5a1_96886b89fb95
initial amount: NaN
is: P42765
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: ACAA2
is encoded by: hsa:10449
initial concentration: NaN
boundary condition: true

metaR r0033
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaR CDIPTr
type: Reaction
product: MODEL1310110038#
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.8.11
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
name: phosphatidylinositol synthase (Homo sapiens)

metaM 3hexdcoa m
is: SBO:0000247
initial amount: NaN
is: C05258
initial concentration: 1.0
name: 3-hydroxyhexadecanoylcoa
is: HMDB03932
boundary condition: false
has only substance units: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
type: Species
constant: false

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: C01342
initial amount: NaN
is: CHEBI:28938
has only substance units: false
name: Ammonium

metaM uacgam c
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
has only substance units: false
is: SBO:0000247
is: HMDB00290
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

metaR H7 TAer
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: H7' transamidase, endoplasmic reticulum
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
product: MODEL1310110038#

metaR r0921
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
name: Postulated transport reaction
fast: false

metaR r2094
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
modifier: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_e841d541_7f47_4d36_ba72_9c5bd2c0db2f
initial amount: NaN
has part: P34059
is encoded by: hsa:2720
is encoded by: hsa:4758
type: Species
is encoded by: hsa:2588
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
has part: P16278
constant: false
has part: Q99519
has only substance units: false
is encoded by: hsa:5476
has part: P10619
initial concentration: NaN
is: SBO:0000297

metaM etoh c
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16236
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00108
name: ethanol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0999392d_b554_49ff_ace7_b42ba8bb2367
type: Species
constant: false
name: SLC19A3
is encoded by: hsa:80704
is: SBO:0000252
is: Q9BZV2
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_20b1c64b_ac14_41ff_acd9_11ea1d1dd639
name: UGDH
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O60701
is encoded by: hsa:7358
has only substance units: false

metaM gmp e
constant: false
name: GMP(3-)
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01397
has only substance units: false
is: SBO:0000247
is: CHEBI:58115

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
name: 3',5'-cyclic AMP(1-)
is: SBO:0000247
constant: false
is: CHEBI:58165
initial amount: NaN
type: Species
is: HMDB00058
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR PCRNtm
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
name: transport into the mitochondria from cytosol (carnitine)
fast: false

metaR r1635
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaM tcynt e
is: SBO:0000247
is: HMDB01453
has only substance units: false
type: Species
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18022
name: thiocyanate
constant: false

metaR 4ABUTtm
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
kinetic law: MODEL1310110038#
reversible: true
name: 4-aminobutanoate mitochondrial transport via diffusion
is described by: ECO:0000000

metaM for c
is: HMDB00142
has only substance units: false
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: Formate
type: Species
is: C00058
is: SBO:0000247
is: CHEBI:15740
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_5d041fb6_8dca_436f_9a7b_4d04f0349e09
is encoded by: hsa:5538
constant: false
name: PPT1
type: Species
boundary condition: true
is: Q6FGQ4
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM gmp c
is: HMDB01397
is: CHEBI:58115
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial amount: NaN
name: GMP
is: C00144
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM mthgxl e
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:17158
constant: false
name: methylglyoxal
is: HMDB01167
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247
type: Species

MODEL1310110038#
species: metaM 3mlda e
species: metaM 4mzym int2 r
species: metaM acgam6p c
species: metaM datp c
species: metaM btcoa c
species: metaM 2decdicoa m
species: metaM mal L c
species: metaM pmtcrn r
species: metaM m5mpdol U r
species: metaM HC02208 c
stoichiometry: 0.017486
type: SBMLUnitsDef
species: metaM HC01434 x
species: metaM o2s m
species: metaM 34hpp m
species: metaM 3hddcoa c
species: metaM nad x
species: metaM gdpfuc g
species: metaM ksi pre19 g
species: metaM dump c
species: metaM dolglcp U r
species: metaM asp L m
species: metaM pan4p m
stoichiometry: 0.013306
species: metaM 5oxpro e
species: metaM gal c
species: metaM cyan e
species: metaM paps c
species: metaM atp x
species: metaM pap g
species: metaM retinal r
species: metaM 2mbcoa m
species: metaM cytd c
species: metaM CE1944 c
species: metaM HC02203 e
species: metaM tcynt c
species: metaM lnlccoa c
species: metaM dcamp c
species: metaM c101coa c
species: metaM ocdca e
species: metaM zymstnl r
species: metaM dmhptcrn m
species: metaM xolest2 hs e
stoichiometry: 0.325996
species: metaM urea m
species: metaM acnam l
species: metaM sphmyln hs g
species: metaM 3ivcoa m
species: metaM pail45p hs c
species: metaM pheacgln c
species: metaM ctp n
species: metaM 3hbcoa R c
species: metaM 3htdcoa c
species: metaM 7thf e
species: metaM HC02217 e
species: metaM dolmanp L c
species: metaM pa hs n
species: metaM glyc c
species: metaM ttdca e
species: metaM 3sala c
species: metaM oxa m
species: metaM ksi g
species: metaM c4crn e
species: metaM CE5117 m
species: metaM mal L m
species: metaM chsterol r
species: metaM spmd c
species: metaM dadp n
species: metaM ksi deg29 l
species: metaM itp c
species: metaM 34dhphe c
species: metaM sT antigen g
species: metaM xylt e
species: metaM tchola c
species: metaM dnad c
species: metaM ptdcacrn c
species: metaM 2maacoa m
species: metaM ppi r
species: metaM trdrd m
species: metaM HC02121 c

metaR AICARte
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reactant: MODEL1310110038#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR r2095
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110038#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_01cb636e_6ff4_4845_ae56_87708e55263d
has only substance units: false
initial amount: NaN
name: BDH1
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q02338
type: Species
is encoded by: hsa:622

metaM bamppald c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7975
constant: false
is: C05665
initial amount: NaN
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
type: Species
is: HMDB01106
boundary condition: false
is: SBO:0000247
has only substance units: false
name: beta-Aminopropion aldehyde

metaR SERGLNNaEx
name: L-serine/L-glutamine Na-dependent exchange (Ser-L in)
reactant: MODEL1310110038#
is described by: ECO:0000269
fast: false
product: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110038#

metaM malthx e
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: SBO:0000247
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
initial amount: NaN
is: C01936
name: Maltohexaose

metaR r1634
type: Reaction
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_87cad940_f513_4046_b716_8fcc3ced32f0
has only substance units: false
is: SBO:0000252
name: NOS1
initial amount: NaN
type: Species
constant: false
is: B4DG68
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4842

http://identifiers.org/biomodels.db/MODEL1310110038#_341da626_87f7_42e1_8e07_e4cb2fcc717d
is encoded by: hsa:4536
name: ND2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q7GXY9
type: Species
has only substance units: false

metaM subeac c
boundary condition: false
has only substance units: false
name: suberic acid
is: HMDB00893
notes: FORMULA: C8H12O4 CHARGE: -2
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN

metaR EX ivcrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM ksi deg1 l
constant: false
is: SBO:0000247
type: Species
is: HMDB00174
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
initial concentration: 1.0
is: CHEBI:18287
has only substance units: false
boundary condition: false
initial amount: NaN

metaM paps g
is: HMDB01134
boundary condition: false
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM 4abut c
is: CHEBI:3628
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
name: 4-Aminobutanoate
is: C00334
constant: false
is: HMDB00112
boundary condition: false
initial concentration: 1.0

metaR 3DPHBH1
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110038#
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
product: MODEL1310110038#
reversible: false
is described by: ECO:0000000

metaR CYTK1n
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
fast: false
reversible: true

metaR UGCG
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.80
product: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
name: Ceramide glucosyltransferase

metaM dhcholestanate c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:16577
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

http://identifiers.org/biomodels.db/MODEL1310110038#_5a4a28b8_adb9_4d6b_ba1d_fa865a51bdb5
constant: false
is: SBO:0000252
is encoded by: hsa:1962
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: EHHADH
initial concentration: NaN
is: Q9NY65

W3 CDTF: Wed Aug 29 22:29:57 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110038#_9e169272_16a4_48da_a0b9_f990e5aba845
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q92569
is encoded by: hsa:8503
has only substance units: false
name: PIK3R3
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_862c74bc_70d7_4fed_b1e6_740a371ec085
type: Species
is encoded by: hsa:4705
name: NDUFA10
is: O95299
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN

metaM dmnoncoa m
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB11604
name: 4,8 dimethylnonanoyl-CoA
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_836654c6_fb47_4bf0_befe_1fb7d1dc4da1
type: Species
is: Q6TCH8
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10873
initial amount: NaN
name: ME3
constant: false
initial concentration: NaN

metaR GUAPRT
reversible: false
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
name: guanine phosphoribosyltransferase
is: SBO:0000176
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.2.8

metaM mi1345p c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: CHEBI:57895
has only substance units: false
is: HMDB01059
constant: false
type: Species
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial amount: NaN

metaM 34dhoxmand m
name: 3,4-Dihydroxymandelate
initial concentration: 1.0
boundary condition: false
is: HMDB01866
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM adpcoa c
is: C14143
initial concentration: 1.0
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
type: Species
is: SBO:0000247
has only substance units: false
name: adipoylcoa
initial amount: NaN
is: HMDB04047
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_43980de5_d7e1_4387_bf27_3a00a7e14df3
constant: false
name: SLC17A7
is: SBO:0000252
is: Q9P2U7
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:57030
boundary condition: true
initial concentration: NaN

metaR RE1448N
reversible: true
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000
name: RE1448
is: SBO:0000176
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

metaM itaccoa m
initial concentration: 1.0
type: Species
is: HMDB03377
constant: false
name: itaconyl-CoA(5-)
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57381

metaM 4abut e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false
is: C00334
type: Species
constant: false
is: HMDB00112
name: 4-Aminobutanoate
is: CHEBI:3628
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_d7c7511e_21bf_4d5e_8c3f_23476726ca19
has only substance units: false
is: Q3MHC9
boundary condition: true
initial amount: NaN
is encoded by: hsa:23517
is: SBO:0000252
constant: false
name: SKIV2L2
initial concentration: NaN
type: Species

metaR r1984
product: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110038#
name: Y+LAT2 Utilized transport
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a85d2198_1b24_4777_954e_a1668c4b2699
name: ACAT2
is encoded by: hsa:39
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q9BWD1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_ba6f01e6_84bc_4a26_9b3d_f9a60ea35910
name: ENTPD5
boundary condition: true
constant: false
is encoded by: hsa:957
has only substance units: false
type: Species
is: O75356
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_848f97b3_8369_4ed4_8ca9_b2b56f74c98b
boundary condition: true
name: VNN1
type: Species
has only substance units: false
constant: false
is: O95497
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8876
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_780f7fc7_eb84_4771_bd58_ffb22656cd4f
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:53354
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: PANK1

metaR FAOXC15C13m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_9c7de76f_5d5b_4c8d_bcb6_1267a7af6855
is encoded by: hsa:2352
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: Q05C14
boundary condition: true
name: FOLR3
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_fc010c42_2a5e_426e_a491_dce922e7f3b3
name: PIK3CB
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5291
boundary condition: true
is: B4DER4
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR GLYt7 211 r
type: Reaction
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
fast: false
product: MODEL1310110038#
name: glycine reversible transport via sodium and chloride symport (2:1:1)

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_fc6c47fa_e5e4_4a3f_bd3b_0784cb456bef
name: NDUFAB1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4706
initial amount: NaN
is: O14561
constant: false
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_dd66b8fd_fd77_4293_82e2_6963b58b43d5
name: ST3GAL1
type: Species
has only substance units: false
is encoded by: hsa:6482
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is: Q11201
boundary condition: true

metaR RE3568C
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3568
reactant: MODEL1310110038#
product: MODEL1310110038#

metaR ADK1m
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
fast: false
modifier: MODEL1310110038#
name: adenylate kinase, mitochondrial
kinetic law: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#

metaR NACHEX27ly
is described by: ECO:0000269
reactant: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reversible: false
product: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#

metaR CYTK1m
type: Reaction
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
is: SBO:0000176
reactant: MODEL1310110038#
name: cytidylate kinase (CMP),mitochondrial
reversible: true
is described by: ECO:0000134
product: MODEL1310110038#

metaM lnlncg c
type: Species
boundary condition: false
is: CHEBI:32391
is: HMDB03073
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
constant: false
name: gamma-linolenate
is: SBO:0000247
has only substance units: false

metaM tmndnccrn m
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
initial amount: NaN
is: SBO:0000247
is: HMDB12130
is: CHEBI:16987
boundary condition: false
name: Timnodonyl carnitine
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_9e9c8426_84b8_45ce_91fe_5f17aed1bff3
type: Species
name: DPYS
is: Q14117
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1807
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_c01a201d_5b46_4e71_a3bb_55ad1b7fe3f4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: P13866
type: Species
name: SLC5A1
is encoded by: hsa:6523

metaM adrnl c
constant: false
is: CHEBI:33568
boundary condition: false
name: Adrenaline
is: SBO:0000247
is: HMDB00068
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H14NO3 CHARGE: 1 INCHI: InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 EHMN_ABBREVIATION: C00788

metaM thymd c
is: C00214
is: SBO:0000247
boundary condition: false
name: Thymidine
constant: false
is: HMDB00273
initial concentration: 1.0
is: CHEBI:17748
has only substance units: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
type: Species
initial amount: NaN

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3

metaM dd3coa x
name: 3-dodecenoylcoa
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
is: HMDB04257
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR SIAASE3ly
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
name: sialidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176

metaR FORMCOAtx
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: formyl coa transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
fast: false

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
initial amount: NaN
name: cis-deca-4-enoyl-CoA
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
has only substance units: false

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_336607c1_bf8b_4dcf_815e_1905662802a5
is encoded by: hsa:6514
constant: false
type: Species
initial amount: NaN
name: SLC2A2
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P11168
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_d71270bf_916c_4672_972e_89e237f8fe19
is encoded by: hsa:6888
constant: false
has only substance units: false
name: TALDO1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P37837
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_12b7b835_c59e_4668_b91c_3302c77f20d0
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:23396
is: SBO:0000252
is: O60331
name: PIP5K1C
initial concentration: NaN

metaR CYTK10n
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110038#
product: MODEL1310110038#
name: cytidylate kinase (CMP,dGTP),nuclear
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false

metaM ddece1crn c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: dodecenoyl carnitine
boundary condition: false
type: Species
is: HMDB03712
notes: FORMULA: C19H35NO4 CHARGE: 0

metaR 3AIBtm
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: false
name: 3-amino-isobutyrate transport, mitochondrial
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_b98adbb4_b1b8_4cdd_b995_3412020153b9
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q9BXI2
is encoded by: hsa:83884
name: SLC25A2

http://identifiers.org/biomodels.db/MODEL1310110038#_2f2ea844_1e62_41ae_9099_159374d89da4
initial amount: NaN
is encoded by: hsa:AI620219
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _AI620219_1_m
type: Species
constant: false
has only substance units: false

metaR RETt
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: Retinol transport via faciliated diffusion

metaM tettet6coa c
is: C16171
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: tetracosatetraenoyl coenzyme A
constant: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: HMDB06516
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205481
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_eaafe3b5_e737_4f51_a71f_50609277f404
is: Q8TDQ7
is: SBO:0000252
type: Species
is encoded by: hsa:132789
constant: false
name: GNPDA2
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR C4tcx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM dlnlcgcoa r
is: C03595
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r0186
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
type: Reaction
modifier: MODEL1310110038#

metaM 3aib m
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
is: SBO:0000247
initial concentration: 1.0
is: HMDB02166
name: (S)-3-aminoisobutyric acid
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_69a19ea7_3b29_4a93_805c_9bf44e6bfada
is: SBO:0000252
name: _AV717590_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AV717590

metaR SPHK21c
name: sphingosine kinase 2
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.91
reactant: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ

metaM 3ivcoa c
constant: false
boundary condition: false
initial amount: NaN
is: HMDB06870
name: 3-hydroxyisovalerylcoa
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/11966188
is: C05998
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR EX hista LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Histamine exchange
type: Reaction

metaR C4STMO2Pr
name: C-4 methyl sterol oxidase
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_005496ca_b2ee_4651_ade1_4103b5ea3793
name: RRM2B
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:50484
is: SBO:0000252
is: Q7LG56
has only substance units: false
type: Species

metaR RE1796M
kinetic law: MODEL1310110038#
is: SBO:0000176
name: RE1796
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reversible: true
product: MODEL1310110038#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaR G14T4g
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110038#

metaR ATPH2e
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110038#
name: ATP diphosphohydrolase
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
fast: false

metaR r1788
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110038#
reversible: false
product: MODEL1310110038#
type: Reaction

metaR HCO3 CLt
reversible: true
type: Reaction
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
name: bicarbonate transport (Cl-/HCO3- exchange)
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
is: SBO:0000185

metaM ddece1crn e
notes: FORMULA: C19H35NO4 CHARGE: 0
is: C02838
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00791
boundary condition: false
is: SBO:0000247
name: dodecenoyl carnitine
constant: false
initial amount: NaN

metaR FAOXC225x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_5ae76d8b_6f72_49e9_8570_d5e096bec3f7
type: Species
is encoded by: hsa:M68895
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: _M68895_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_1b0a8f7a_b899_4813_84f7_6ba9c81a6f93
has only substance units: false
initial concentration: NaN
has part: Q9NY65
boundary condition: true
initial amount: NaN
constant: false
name: EHHADH:ACAA1:ACOX1
is: SBO:0000297
type: Species
is encoded by: hsa:1962

metaR r0463
kinetic law: MODEL1310110038#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
product: MODEL1310110038#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10

http://identifiers.org/biomodels.db/MODEL1310110038#_16c849ec_7d79_4c71_a958_7e9bb2203447
initial amount: NaN
is encoded by: hsa:4708
name: NDUFB2
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: H7C5B8
is: SBO:0000252
type: Species

metaR GLACter
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD

metaR URCN
type: Reaction
modifier: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.49
kinetic law: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110038#
name: URCN
reactant: MODEL1310110038#

metaM frdp r
initial concentration: 1.0
is: CHEBI:175763
constant: false
boundary condition: false
type: Species
is: C00448
name: Farnesyl diphosphate
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961

http://identifiers.org/biomodels.db/MODEL1310110038#_54d1bbb5_b3db_4507_b6bb_641cecbf798a
is encoded by: hsa:2348
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: FOLR1

metaR C14OHc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_7912558b_7a55_4251_9559_bb36a935c132
is encoded by: hsa:8140
constant: false
name: SLC3A2:SLC7A5
has only substance units: false
type: Species
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
has part: Q8IV97
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_768e8e40_e7e1_40af_90aa_c9199f09bc12
is encoded by: hsa:22305
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _22305_1_c
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR FAOXC123x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaR LTD4DP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
is: SBO:0000176
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
reactant: MODEL1310110038#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaR FACOAL80i
is described by: ECO:0000269
name: fatty-acid--CoA ligase (octanoate)
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false

metaR FAOXC14C12m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR FAOXC8C6m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR HEXDICOAACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.1.6.4
name: sialidase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110038#
is described by: ECO:0000000
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false

metaM ump m
initial concentration: 1.0
name: UMP(2-)
type: Species
is: HMDB00288
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: CHEBI:57865
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_53b8f520_8b15_4903_ac04_ab16d52a72d8
name: LCT
is: P09848
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:3938
initial amount: NaN

metaR 3AIBTm
is described by: ECO:0000304
reactant: MODEL1310110038#
fast: false
name: L-3-aminoisobutyrate transaminase, mitochondrial
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110038#

metaR ACRNtm
product: MODEL1310110038#
reversible: false
fast: false
name: O-acetylcarnintine transport into mitochondria via diffusion
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:977593 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110038#

metaR RE1826C
product: MODEL1310110038#
name: RE1826
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_aae9efc2_c032_4c07_8e1d_4d21e6713b29
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:6487
initial concentration: NaN
is: SBO:0000252
name: ST3GAL3

metaM fprica c
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: HMDB01439
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58467
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: C04734

metaM c16dc e
notes: FORMULA: C23H42NO6 CHARGE: -1
type: Species
name: Hexadecanedioic acid mono-L-carnitine ester
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00712

http://identifiers.org/biomodels.db/MODEL1310110038#_a6cbce9a_3406_41a1_97df_cd04680d8ffb
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: B7Z2T0
is encoded by: hsa:478
has only substance units: false
name: ATP1A3

metaR FAOXTC182TC162m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaM trp L e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
boundary condition: false
is: HMDB00929
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16828
name: L-tryptophan

http://identifiers.org/biomodels.db/MODEL1310110038#_5cb7fdd1_b40f_4c09_9e35_1b522410594d
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: P60891
is encoded by: hsa:5631
boundary condition: true
name: PRPS1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_b402220a_8bb9_429d_917a_e153bb956160
is encoded by: hsa:175
is: P20933
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: AGA

http://identifiers.org/biomodels.db/MODEL1310110038#_5e55b93a_2728_43a3_a7a6_e4d211ad4900
name: MVD
initial amount: NaN
constant: false
is encoded by: hsa:4597
boundary condition: true
has only substance units: false
is: P53602
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_6280d07d_bc30_4bf9_a81c_ce955bc5d802
name: _T83654_1_c
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:T83654
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_82a6c0a3_b53d_4253_bdef_645f2b4a3f81
initial concentration: NaN
has only substance units: false
is: Q86YN1
initial amount: NaN
boundary condition: true
constant: false
name: DOLPP1
is encoded by: hsa:57171
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_58ce2c73_bc19_4dbe_890a_a63dadd21864
type: Species
is: SBO:0000252
name: ENTPD1
has only substance units: false
initial amount: NaN
is: Q86VV3
constant: false
boundary condition: true
is encoded by: hsa:953
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_1abb221b_d339_4db5_9647_495afcfe3b74
is encoded by: hsa:5295
boundary condition: true
has part: B3KT19
name: PIK3CB:PIK3R1
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5291
has part: B4DER4
type: Species
initial amount: NaN
constant: false

metaR NaKt
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: Na+/K+ exchanging ATPase
is version of: http://identifiers.org/ec-code/3.6.3.9
modifier: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)

metaM ksi pre36 g
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 36

http://identifiers.org/biomodels.db/MODEL1310110038#_99347723_9bfc_46f3_b73c_57c0d93ec79d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: CPT1B
type: Species
is: Q53FV7
is encoded by: hsa:1375
initial amount: NaN
boundary condition: true
constant: false

metaR GGH 7THFe
type: Reaction
modifier: MODEL1310110038#
name: Gamma-glutamyl hydrolase (7THF), extracellular
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
reversible: false
product: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1aabcd94_d351_4ddf_ab5b_ba1f7b228aaa
initial concentration: NaN
has only substance units: false
is: Q9BYC2
is encoded by: hsa:64064
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: OXCT2

http://identifiers.org/biomodels.db/MODEL1310110038#_a24b32ad_91f3_4799_adbd_d9d30f2120c1
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:641649
has only substance units: false
constant: false
is: C9JZ62
name: TMEM91
is: SBO:0000252
type: Species

metaM cs a deg4 l
is: HMDB00812
initial amount: NaN
notes: FORMULA: C31H49NO29S CHARGE: -2
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16953
constant: false
type: Species

metaR NDP7er
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
kinetic law: MODEL1310110038#

metaM 2mb2coa m
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 2-methylcrotonoyl-CoA(4-)
is: CHEBI:57337

metaM c16dc c
name: Hexadecanedioic acid mono-L-carnitine ester
type: Species
initial amount: NaN
is: HMDB00712
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C23H42NO6 CHARGE: -1

metaR FERO
reactant: MODEL1310110038#
name: ferroxidase
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000134

metaM gpi sig r
is: CHEBI:58190
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: HMDB00224
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: Y CHARGE: 0

metaM HC00460 c
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
boundary condition: false
has only substance units: false
is: CHEBI:58044
type: Species

metaR ADRNt
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
is: SBO:0000185
fast: false

metaM cs e deg7 l
constant: false
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
notes: FORMULA: C23H35O27S2 CHARGE: -3
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:15936
type: Species
initial concentration: 1.0

metaR CYSGLUexR
fast: false
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110038#
modifier: MODEL1310110038#
name: L-cysteine/L-glutamine reversible exchanger
is described by: ECO:0000304
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_30165aa0_382f_493a_9d76_c58536023a7e
is: SBO:0000252
type: Species
initial amount: NaN
is: P43007
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:6509
name: SLC1A4
initial concentration: NaN

metaR RE3524R
is: SBO:0000176
reactant: MODEL1310110038#
name: RE3524
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_7ddd8f46_ae64_47f9_845f_f8e81a7226e6
initial amount: NaN
name: B4GALT3
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: A8K5Z0
constant: false
is encoded by: hsa:8703
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_89102a39_c23a_44dd_a173_693b6f9ad3aa
has only substance units: false
name: NNT
is encoded by: hsa:23530
boundary condition: true
constant: false
is: Q13423
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR EX 3deccrn
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaR r1851
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110038#
modifier: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_dac78fc6_d19e_40de_b480_2ed55bfe66e7
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q6P1K9
constant: false
boundary condition: true
is encoded by: hsa:80025
is: SBO:0000252
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110038#_52375cc4_669d_4dc8_8edc_cb9266340db0
type: Species
initial concentration: NaN
is: SBO:0000252
name: PYCRL
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:65263
initial amount: NaN
is: Q53H96

metaM ump n
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
is: HMDB00288
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57865
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM CE2420 m
is: SBO:0000247
is: HMDB11123
has only substance units: false
initial amount: NaN
is: CHEBI:28387
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial concentration: 1.0
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_97454c65_1c36_4c00_8187_d18cb6f0e548
boundary condition: true
is: SBO:0000252
is: Q96NT5
name: SLC46A1
has only substance units: false
is encoded by: hsa:113235
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR DINt
is described by: ECO:0000000
reversible: true
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110038#
name: deoxyinosine transport via diffusion

metaR r0899
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
kinetic law: MODEL1310110038#
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_6c7845bf_a2f7_4f0f_978b_618dad1ea55b
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:349565
is: Q96T66
boundary condition: true
initial amount: NaN
name: NMNAT3
constant: false
initial concentration: NaN

metaR NDPK1m
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000254
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110038#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
type: Reaction
reversible: true

metaR FAOXC81C61x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_510fc807_a139_42b8_8533_03e037e09176
is: O15120
name: AGPAT2
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:10555
type: Species

metaM 13 cis retn r
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7847414
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
has only substance units: false
constant: false
boundary condition: false
name: 13-cis-retinoate
type: Species
is: HMDB06219
initial concentration: 1.0

metaR LYStip
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
product: MODEL1310110038#
fast: false
is: SBO:0000185
reactant: MODEL1310110038#
name: L-lysine transport, peroxisomal (irreversible)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_fc11a51d_ee55_4b56_98ac_2f6ee4312f6a
has only substance units: false
boundary condition: true
initial concentration: NaN
is: O75354
constant: false
name: ENTPD6
is: SBO:0000252
is encoded by: hsa:955
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_c2bf9637_7922_4282_b9f6_0f39e3b5c17c
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4645
name: MYO5B
is: SBO:0000252
type: Species
is: Q9H6Y6
initial concentration: NaN
initial amount: NaN

metaM retinal cis 9 c
constant: false
has only substance units: false
is: HMDB01358
is: CHEBI:17898
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: SBO:0000247
name: all-trans-retinal
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaM o2s c
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
initial concentration: 1.0
name: superoxide
type: Species
is: HMDB02168
constant: false
is: CHEBI:18421
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b8d80e1c_a329_4c05_a5b9_2544bad29bb4
is: SBO:0000297
has part: Q6IBB3
constant: false
is encoded by: hsa:516
has part: Q08ET0
initial concentration: NaN
is encoded by: hsa:10632
boundary condition: true
is encoded by: hsa:522
is encoded by: hsa:4905
is encoded by: hsa:10476
has part: P05496
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has only substance units: false
has part: A0PJH2
initial amount: NaN
is encoded by: hsa:521
type: Species
has part: P46459
has part: O75964
is encoded by: hsa:9551
has part: P56385

metaM bhb m
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
boundary condition: false
initial concentration: 1.0
is: HMDB00011
has only substance units: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_278d2f6e_466d_4bc0_99bd_fc4d6c43588a
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:5331
constant: false
is: G5E960
is: SBO:0000252
name: PLCB3
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_f2951180_ac62_4f9c_891f_c13957032c25
is encoded by: hsa:23563
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: CHST5
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_bedcae2e_9fb8_4acc_8878_71d2a4f40782
is: O75874
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3417
type: Species
initial amount: NaN
name: IDH1

metaR r0331
kinetic law: MODEL1310110038#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_213f011e_cbf2_40b4_aaab_2193623de36e
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:2348
name: FOLR1
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM hestratriol c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 4,17 dihydroxy estradiol
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
boundary condition: false
is: HMDB05896
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e0a62e3d_498a_4afe_8778_0a63efd8d7d6
is: E9PCP2
name: CPT1B
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1375
constant: false
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_cb3afea3_cea8_40a2_b4f1_b774759ceaf0
name: ALG3
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:10195
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1c4b3567_64a1_465c_a66c_b4db624d4452
name: GPX6
is: P59796
initial amount: NaN
is encoded by: hsa:257202
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_82d98a5a_6856_4025_815c_398f1673a9b3
has only substance units: false
initial concentration: NaN
name: INPP4A
type: Species
is encoded by: hsa:3631
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_271755ab_2370_4fe6_a0b7_4e2bca250b28
boundary condition: true
constant: false
is encoded by: hsa:54363
is: Q9UJM8
has only substance units: false
type: Species
name: HAO1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM mi1p D c
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58433
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_1f834d9a_86b4_46dd_8712_eb07ff134d4f
name: ST3GAL3
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6487
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q5T4W8

metaM o2s e
has only substance units: false
type: Species
is: HMDB02168
initial concentration: 1.0
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
name: superoxide
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM succ x
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00254
initial concentration: 1.0
is: CHEBI:30031
is: C00042

metaR ASNGLNNaEx
reversible: false
is: SBO:0000185
reactant: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
name: L-glutamine/L-asparagine Na-dependent exchange (Asn-L in)

http://identifiers.org/biomodels.db/MODEL1310110038#_8583c939_69c8_4b79_9e6b_cf5658199e83
type: Species
initial concentration: NaN
has only substance units: false
is: Q92959
name: SLCO2A1
is encoded by: hsa:6578
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR ASPDxt
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reactant: MODEL1310110038#
fast: false
type: Reaction
name: D-aspartate transport, peroxisomal
is: SBO:0000185
product: MODEL1310110038#
reversible: true

metaR AKR1C42
reversible: false
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
is: SBO:0000176
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
is described by: ECO:0000269
reactant: MODEL1310110038#

metaM ump r
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
is: HMDB00288
boundary condition: false
name: UMP
constant: false
type: Species
is: CHEBI:57865
has only substance units: false

metaM ivcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
initial amount: NaN
name: Isovaleryl-CoA
boundary condition: false
has only substance units: false
is: HMDB01113
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57345

http://identifiers.org/biomodels.db/MODEL1310110038#_078867de_8460_46db_a1c8_ef0810213fa6
name: SLC9A3
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6550
initial amount: NaN
is: SBO:0000252
is: P48764

metaR r0224
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: false
modifier: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
is described by: ECO:0000000
product: MODEL1310110038#

metaM HC01434 x
name: oxalatosuccinate(3-)
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58931
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
boundary condition: false

metaM q10 e
initial concentration: 1.0
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:46245
type: Species
boundary condition: false
name: ubiquinone-10

metaM 3bcrn c
boundary condition: false
constant: false
has only substance units: false
name: 3-hydroxy butyryl carnitine
notes: FORMULA: C11H21NO5 CHARGE: 0
initial concentration: 1.0
is: C14143
type: Species
is: HMDB04047
initial amount: NaN
is: SBO:0000247

metaR PTDCAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110038#
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_09ea8f11_12fb_4685_9ea2_9f6b31793e54
has only substance units: false
boundary condition: true
name: AKR1C4
constant: false
is: P17516
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1109
type: Species
is: SBO:0000252

metaR DHCR71r
reversible: false
product: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
is described by: ECO:0000134

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM hpdcacoa m
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB06497
type: Species
is: SBO:0000247
name: heptadecanoyl coa
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1

metaM 6a2ohxnt x
boundary condition: false
is: CHEBI:17534
is: HMDB12151
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial concentration: 1.0
name: 6-amino-2-oxohexanoic acid
has only substance units: false
is: SBO:0000247
type: Species
constant: false

metaM ump e
initial concentration: 1.0
is: CHEBI:57865
boundary condition: false
is: HMDB00288
is: SBO:0000247
name: UMP(2-)
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR r2106
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false

metaM ala B c
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00056
type: Species
name: beta-alanine
is: CHEBI:16958
initial concentration: 1.0

metaR P45011A1m
type: Reaction
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.15.6
is: SBO:0000176
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
product: MODEL1310110038#
name: Cytochrome P450 11A1, mitochondrial [Precursor]

http://identifiers.org/biomodels.db/MODEL1310110038#_a70187bd_2f9b_48e4_b6c6_3030ae6b809d
initial concentration: NaN
is encoded by: hsa:51805
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9NZJ6
type: Species
name: COQ3

http://identifiers.org/biomodels.db/MODEL1310110038#_e1b3f0ec_5c9e_4bce_9557_71ac8c18e4a9
has only substance units: false
name: SUCLG1:SUCLA2
is: SBO:0000297
initial amount: NaN
has part: E5KS60
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8803
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_ea78b06a_a27a_4c1c_9c72_ae78bffbf210
name: HAO2
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9NYQ3
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51179
constant: false

metaR FAOXC101C102m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR r1007
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_c0d1e6df_1138_453c_a041_c29e508130f7
has only substance units: false
type: Species
initial concentration: NaN
name: ACADVL
is: SBO:0000252
is: P49748
initial amount: NaN
is encoded by: hsa:37
constant: false
boundary condition: true

metaR r0789
is: SBO:0000176
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110038#
type: Reaction
reversible: true
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_656f6c01_fc48_4c40_88ab_4ec382888683
is: Q9NRZ5
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: AGPAT4
is encoded by: hsa:56895
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR FAOXC122m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR r2105
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
fast: false
is described by: ECO:0000000
product: MODEL1310110038#

metaM ump g
has only substance units: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:57865
initial amount: NaN
type: Species
name: UMP(2-)

metaR C16DCe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_b626e2ec_7cca_4c5e_ad89_1fa566c81ac4
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10678
constant: false
is: SBO:0000252
name: B3GNT2
boundary condition: true

metaR RE3242R
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reversible: true
name: RE3242
type: Reaction
kinetic law: MODEL1310110038#

metaR LEUPHELAT2tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM ctp c
is: SBO:0000247
is: HMDB00082
is: C00063
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial amount: NaN
is: CHEBI:37563
name: CTP

metaR TTDCAFATPc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM c8dc c
initial amount: NaN
constant: false
name: suberyl carnitine
is: C02838
is: SBO:0000247
notes: FORMULA: C15H26NO6 CHARGE: -1
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00791

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_011dde7d_4ea9_4c21_a7fb_a26acc407193
is: P61457
has only substance units: false
name: PCBD1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5092
type: Species

metaR BUTt2m
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
name: Butyrate mitochondrial transport via proton symport, reversible
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_f6299d84_31a6_40d0_8cf4_0fb762ca50db
boundary condition: true
initial amount: NaN
name: PIK3R1
type: Species
initial concentration: NaN
is encoded by: hsa:5295
constant: false
has only substance units: false
is: SBO:0000252
is: B3KT19

metaR 3MLDAt
is: SBO:0000185
fast: false
name: 3MLDA extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaR NDPK1n
type: Reaction
product: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
is described by: ECO:0000134
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is: SBO:0000176

metaR MDHx
fast: false
type: Reaction
name: malate dehydrogenase, peroxisomal
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
reactant: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_1c269c9c_be85_4d8c_aa7b_ece938cd4883
boundary condition: true
name: ACLY
is encoded by: hsa:47
initial amount: NaN
is: P53396
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaM 2mb2coa c
initial amount: NaN
type: Species
is: HMDB02054
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
name: 2-methylcrotonoyl-CoA(4-)
constant: false
initial concentration: 1.0

metaR r2103
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110038#

metaR RE3566C
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
name: RE3566
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_2d975e2d_92e5_437b_9b7a_90faabffb45a
is: P10768
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2098
type: Species
has only substance units: false
name: ESD

http://identifiers.org/biomodels.db/MODEL1310110038#_b51808bc_4fe3_400e_a883_fee39f925d11
has only substance units: false
name: STS
initial amount: NaN
is: P08842
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:412
boundary condition: true

metaR r1743
reversible: false
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_23912a55_b667_4e06_84f1_375b9a75dd3b
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: _83530_1_c
is encoded by: hsa:83530
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_bf1b1a5e_4e45_48e7_bd9f_b3dd5db3401d
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:83549
is: Q5JT09
name: UCK1

metaR FAOXC143C123x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR S6T1g
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6eca3cfc_b94f_4121_9181_46a19e025d91
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
is encoded by: hsa:515
type: Species
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
constant: false
boundary condition: true

metaM ivcoa c
is: HMDB01113
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
name: Isovaleryl-CoA
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR DHDPBMTm
fast: false
name: dihydroxydecaprenylbenzoate methyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.114
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
is: SBO:0000176
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaR ALACYSNaEx
fast: false
reversible: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
product: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
name: L-alanine/L-cysteine Na-dependent exchange (Ala-L in)

metaM ctp e
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00082
is: CHEBI:37563
name: CTP(4-)
initial concentration: 1.0
boundary condition: false

metaR NACHEX9ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110038#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: false
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM ahcys m
boundary condition: false
initial amount: NaN
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
is: HMDB00939
is: C00021
has only substance units: false
is: SBO:0000247
constant: false

metaR r2109
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_486edbfa_e3d4_4d66_b6b9_b790308bc4cf
boundary condition: true
initial amount: NaN
name: PIK3C3
has only substance units: false
is encoded by: hsa:5289
initial concentration: NaN
constant: false
is: Q8NEB9
is: SBO:0000252
type: Species

metaR r0339
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaR 13DAMPPOX
kinetic law: MODEL1310110038#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
type: Reaction
product: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#

metaM m8mpdol U r
is: SBO:0000247
is: CHEBI:59093
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
boundary condition: false

metaR HEXDIACTD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM octe5coa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 5-octenoylcoa
boundary condition: false
has only substance units: false
constant: false

metaM q10 c
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
has only substance units: false
is: HMDB01072
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: ubiquinone-10
is: CHEBI:46245
initial amount: NaN

metaM 3bcrn e
type: Species
is: HMDB04047
initial amount: NaN
is: C14143
has only substance units: false
boundary condition: false
name: 3-hydroxy butyryl carnitine
notes: FORMULA: C11H21NO5 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR GLRASE
name: glucuronolactone reductase
is: SBO:0000176
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110038#_dfc185e6_93bc_46fe_aea0_bbd34b0a0182
is encoded by: hsa:230
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: ALDOC
is: P09972

metaR SULFOX
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.8.3.1
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14729666 NOTES:MM/TDV; r0140
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
name: sulfite oxidase
reversible: false
reactant: MODEL1310110038#
fast: false

metaR r2108
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR GLUDxm
is version of: http://identifiers.org/ec-code/1.4.1.3
name: glutamate dehydrogenase (NAD) (mitochondrial)
product: MODEL1310110038#
fast: false
reversible: true
reactant: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_b5729861_eab7_4cb2_b923_d01a7145aa32
has only substance units: false
is: A8K3L7
initial concentration: NaN
is: SBO:0000252
name: CDIPT
initial amount: NaN
is encoded by: hsa:10423
type: Species
boundary condition: true
constant: false

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR DM dttp m
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_93e31844_fb79_4b05_a733_c03c09d82dfd
name: ACOT7
is: O00154
is encoded by: hsa:11332
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_cc7a1878_5e4c_46a3_a97e_7a70233d30d2
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:284111
has only substance units: false
name: SLC13A5
is: Q86YT5

metaR r1570
reactant: MODEL1310110038#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM nicrns c
is: HMDB06809
initial concentration: 1.0
is: CHEBI:58527
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
name: Nicotinate D-ribonucleoside
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
type: Species
constant: false

metaM oxa c
name: oxalate(2-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:30623
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cd5e0a16_f466_4f86_989c_47da2127980e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6309
has only substance units: false
name: SC5DL
constant: false
is: Q6GTM5
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_f41ef88b_9abe_4b38_9f05_08887648fda7
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10637
is: O75610
name: LEFTY1
constant: false
type: Species
initial concentration: NaN

metaR AG13T10g
is described by: ECO:0000000
fast: false
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110038#_a8cea13a_c49b_4405_bd57_1d1952905542
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q9Y217
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9107
boundary condition: true
name: MTMR6

metaR r2107
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
reactant: MODEL1310110038#

metaM ksii core4 pre9 g
initial amount: NaN
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:28067
constant: false
boundary condition: false

metaM o2s m
boundary condition: false
is: C00704
initial amount: NaN
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
is: HMDB02168
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18421
name: Superoxide anion
constant: false

metaR O2Stm
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110038#
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_b6173ad0_7c61_4959_a0d3_298863c90dd8
type: Species
constant: false
name: CDO1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1036
is: Q16878

metaM trp L c
name: L-tryptophan
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
is: HMDB00929

metaM lac L x
name: (S)-lactate
initial amount: NaN
is: HMDB00190
is: CHEBI:16651
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
type: Species

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR INSTt4 2
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
name: inositol transport via sodium symport
is described by: ECO:0000006
is: SBO:0000185
reactant: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_d1cb347f_f8ce_42cc_a948_b059e24e1c34
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54995
name: OXSM
is: Q9NWU1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_f65d2e47_691c_4b97_9b9a_fd15e89398eb
is: P33121
initial amount: NaN
boundary condition: true
is encoded by: hsa:2180
initial concentration: NaN
name: ACSL1
is: SBO:0000252
type: Species
has only substance units: false
constant: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_d86ac88c_1322_4083_940b_203c07269f84
is: Q8WWX8
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: SLC5A11
is encoded by: hsa:115584
constant: false
initial concentration: NaN

metaM dpcoa c
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false
is: HMDB01373
is: SBO:0000247
name: Dephospho-CoA
is: CHEBI:57328
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR CRNtx
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
name: carnitine transport peroxisome to mitochondria
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
reversible: true

metaM lac L e
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16651
has only substance units: false
name: (S)-lactate
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
is: HMDB00190

metaM cs a deg5 l
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15936
boundary condition: false
initial amount: NaN

metaM 3hdeccoa m
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: HMDB02288
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: 3-hydroxyhexadecenoylcoa

metaR CHOLPtg
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
fast: false
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#
name: choline phosphate intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110038#_51e5b909_eadf_4282_b95b_d030210c5705
has only substance units: false
initial amount: NaN
is encoded by: hsa:257068
is: SBO:0000252
boundary condition: true
constant: false
name: PLCXD2
type: Species
is: Q0VAA5
initial concentration: NaN

metaM 5adtststerones e
constant: false
has only substance units: false
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species
initial amount: NaN

metaM pyam5p c
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58451
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
type: Species
name: Pyridoxamine 5'-phosphate
is: C00647
is: SBO:0000247
is: HMDB01555

http://identifiers.org/biomodels.db/MODEL1310110038#_d1078b83_896c_4311_a193_2b0480aa0423
initial concentration: NaN
has only substance units: false
type: Species
is: Q9BZQ4
name: NMNAT2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:23057
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_dba7e50d_0602_4fbd_a3ec_350d67563852
name: NOS3
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:4846
is: SBO:0000252
type: Species
initial amount: NaN
is: A0S0A7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_3119f6c2_fbdd_45e7_a02b_92bc15e1d2ee
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10654
has only substance units: false
constant: false
initial concentration: NaN
name: PMVK
is: Q6FGV9
initial amount: NaN
type: Species

metaM dpcoa e
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
name: Dephospho-CoA
is: C00882
constant: false
is: HMDB01373
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57328

metaM octdececoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species
name: octadecenoylcoa
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false

metaR FAOXC181C161m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR r1571
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM pheacgln c
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
is: HMDB06344
is: SBO:0000247
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
boundary condition: false

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR THRGLYexR
modifier: MODEL1310110038#
name: L-threonine/glycine reversible exchange
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110038#

metaR IDPtn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110038#
name: IDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000

metaR GCALDD
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
product: MODEL1310110038#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
name: Glycolaldehyde dehydrogenase
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r1574
reversible: true
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM lac L c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (S)-lactate
boundary condition: false
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
initial amount: NaN
type: Species
is: HMDB00190

metaM mi1p D n
is: CHEBI:58433
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
initial amount: NaN
is: HMDB02985
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM 3otdcoa m
initial amount: NaN
constant: false
has only substance units: false
is: HMDB03935
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
boundary condition: false
name: 3-Oxotetradecanoyl-CoA
is: CHEBI:28726
type: Species
is: SBO:0000247

metaM 3hodcoa m
name: (S)-3-Hydroxyoctadecanoyl-CoA
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5280355

metaR THCHOLSTOICtm
reversible: true
reactant: MODEL1310110038#
fast: false
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR C161CRN2t
name: C161 transport into the mitochondria
is described by: ECO:0000269
reactant: MODEL1310110038#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
is: SBO:0000185
modifier: MODEL1310110038#

metaM c226coa m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C16169
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479

http://identifiers.org/biomodels.db/MODEL1310110038#_3809a88b_50de_414c_9c1e_7ca59d4824f9
constant: false
has only substance units: false
is: SBO:0000252
is: A3KLL5
initial concentration: NaN
type: Species
is encoded by: hsa:481
initial amount: NaN
name: ATP1B1
boundary condition: true

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
is: CHEBI:57977
name: bilirubin(2-)
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00054

metaR r1573
reactant: MODEL1310110038#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_1a5b6136_3336_4ab7_a024_a4420de66392
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:376497
boundary condition: true
is: SBO:0000252
name: SLC27A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_2cf305d7_4391_4b77_9569_e3d034460416
is encoded by: hsa:3707
constant: false
is: P27987
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ITPKB
boundary condition: true
type: Species
initial amount: NaN

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM hco3 e
boundary condition: false
constant: false
is: C00288
name: Bicarbonate
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00595
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_4b8d6cb9_62a8_4f26_9890_0b556f690610
initial amount: NaN
type: Species
name: ECI2
constant: false
has only substance units: false
boundary condition: true
is: O75521
is encoded by: hsa:10455
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_530bae2e_a303_470a_943b_fb11b4f64eb9
constant: false
type: Species
is encoded by: hsa:19
is: O95477
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ABCA1
initial amount: NaN

metaR r0796
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
modifier: MODEL1310110038#
fast: false
is: SBO:0000176
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110038#

metaM ctp n
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
is: CHEBI:37563
initial amount: NaN
is: HMDB00082
boundary condition: false
type: Species
name: CTP(4-)
initial concentration: 1.0
is: SBO:0000247

metaM hestratriol r
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
initial amount: NaN
type: Species
name: 4,17 dihydroxy estradiol
is: HMDB05896
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

metaR r2101
modifier: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR G14T13g
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110038#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_cd8cdb02_1509_4d03_ae8e_40e10072593a
boundary condition: true
has only substance units: false
name: PPA2
is encoded by: hsa:27068
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: F8WDN9

metaM oxa m
has only substance units: false
is: HMDB02329
initial concentration: 1.0
constant: false
name: oxalate(2-)
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:30623
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209

metaR r0797
is: SBO:0000176
name: glycine N-choloyltransferase EC:2.3.1.65
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110038#
fast: false
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000

metaR HMGCOASim
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_676ad573_c0f0_4f61_ab56_d1e3424e3f4f
initial amount: NaN
type: Species
name: AK2
boundary condition: true
initial concentration: NaN
is encoded by: hsa:204
constant: false
has only substance units: false
is: SBO:0000252

metaM HC01496 m
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28095
name: 2-Amino-3-oxoadipate

metaM stcrn m
name: stearoylcarnitine
has only substance units: false
initial concentration: 1.0
is: HMDB00848
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3

metaR r1576
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
is described by: ECO:0000000

metaM ctp m
name: CTP(4-)
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00082
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
type: Species

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_47613261_8e1c_4c08_b596_357cc1f5e2f1
initial amount: NaN
boundary condition: true
is: A5PKZ1
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:11227
initial concentration: NaN
name: GALNT5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_f70b985f_dd52_4774_a3c8_9794f6213de3
constant: false
name: ENTPD2
is: Q9Y5L3
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:954
type: Species

metaR RE1691M
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.1.1
reversible: true
modifier: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
name: RE1691
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
type: Reaction
fast: false

metaR r2102
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR FAOXC18480m
type: Reaction
is: SBO:0000176
fast: false
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110038#
reactant: MODEL1310110038#

metaR RE0830N
modifier: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true
name: RE0830
reactant: MODEL1310110038#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110038#

metaR NADPHtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
name: NADPH transporter, endoplasmic reticulum
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r1575
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
is described by: ECO:0000000

metaM ala B e
name: beta-alanine
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
is: HMDB00056
initial amount: NaN
is: SBO:0000247
constant: false

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false

metaR r1150
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
name: Facilitated diffusion
reversible: false
type: Reaction
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#

metaR NACHEXA10ly
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110038#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110038#_e2e10dcb_c86b_4317_a2db_740d9712fb0c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80150
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: Q7L266
name: ASRGL1

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ACGAMtly
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
name: N-acetyl-glucosamine lysosomal efflux
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a66ac118_0738_45a3_b96f_eec1faeac1bc
name: _AI915649_1_c
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI915649

metaR SERTHRNaEx
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6509.1) or (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000269
name: L-serine/L-threonine Na-dependent exchange (Ser-L in)
type: Reaction
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_8f520a4d_e1da_4926_9554_a011ae9d1df6
is: SBO:0000252
has only substance units: false
is: A8MU28
initial amount: NaN
name: NAE1
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:8883
boundary condition: true

metaM 5adtststerones c
has only substance units: false
name: 5alpha-Dihydrotestosterone sulfate
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
initial amount: NaN
type: Species

metaR r2100
kinetic law: MODEL1310110038#
fast: false
type: Reaction
reactant: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaM ddcacoa m
is: HMDB03571
initial amount: NaN
is: C01832
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
constant: false
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)

metaM pheacgln e
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
type: Species
constant: false
is: CHEBI:58310
boundary condition: false
initial concentration: 1.0
is: HMDB06344
is: SBO:0000247
has only substance units: false

metaR RE2759X
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/5.1.99.4
product: MODEL1310110038#
fast: false
name: RE2759
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
reversible: true
reactant: MODEL1310110038#
is described by: ECO:0000000

metaR THBPT4ACAMDASE
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: false
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is described by: ECO:0000269
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#

metaR ETFQO
is: SBO:0000176
fast: false
product: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
is described by: ECO:0000000
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.5.1
reversible: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
kinetic law: MODEL1310110038#

metaM glx m
has only substance units: false
type: Species
is: SBO:0000247
name: glyoxylate
constant: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
initial amount: NaN
is: HMDB00119
boundary condition: false
is: CHEBI:36655

http://identifiers.org/biomodels.db/MODEL1310110038#_68fdd53d_3b31_43f2_86e7_5af4e55f939a
initial amount: NaN
type: Species
has only substance units: false
name: DDO
constant: false
is: Q99489
is encoded by: hsa:8528
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR RE0830C
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
name: RE0830
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
type: Reaction
fast: false

metaR CSNATer
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.7
name: carnitine O-acetyltransferase, endolasmic reticulum
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
type: Reaction
fast: false
reactant: MODEL1310110038#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_1e6dd79f_5545_4ce4_9825_9b66bfb131f9
initial concentration: NaN
is: SBO:0000252
is: Q15067
is encoded by: hsa:51
boundary condition: true
name: ACOX1
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM ksii core4 pre7 g
is: C00130
name: keratan sulfate II biosynthesis, precursor 7
is: CHEBI:58053
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110038#_fdf1cfd9_eee2_49c5_9d19_d432c68f7119
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:R51273
name: _R51273_1_c
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM dpcoa l
is: HMDB01373
name: 3'-dephospho-CoA(2-)
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
type: Species
is: CHEBI:57328

metaM srtn c
name: serotonin(1+)
has only substance units: false
is: CHEBI:350546
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00259
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0

metaR r1579
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR SUCCACT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM dlnlcg e
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: HMDB02925
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
name: dihomo-gamma-linolenic acid (n-6)
initial amount: NaN
is: CHEBI:53486

metaR r1466
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110038#
fast: false
type: Reaction
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
name: EC:2.3.1.86

http://identifiers.org/biomodels.db/MODEL1310110038#_fcfc87eb_866f_4ca5_9e5c_92ef0ecc46b0
name: NDUFA13
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9P0J0
constant: false
initial concentration: NaN
is encoded by: hsa:51079
is: SBO:0000252

metaM HC00718 c
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
has only substance units: false
is: CHEBI:57781
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM hestratriol e
type: Species
is: HMDB05896
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
initial amount: NaN
name: 4,17 dihydroxy estradiol
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR GACPAILter
product: MODEL1310110038#
fast: false
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
name: glucosaminyl-acylphosphatidylinositol ER flippase

metaM dpcoa m
is: HMDB01373
name: 3'-dephospho-CoA(2-)
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57328
boundary condition: false

metaR RE2626M
is version of: http://identifiers.org/ec-code/1.14.13.15
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
fast: false
name: RE2626

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: CHEBI:27809
initial concentration: 1.0
is: SBO:0000247
type: Species
name: L-4-hydroxyglutamic semialdehyde
initial amount: NaN
has only substance units: false
is: HMDB06556
constant: false
boundary condition: false

metaR FORtr
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
name: FOR transporter, endoplasmic reticulum
reversible: true
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM mag hs e
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: HMDB03073
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: CHEBI:32391
type: Species
initial concentration: 1.0

metaR KHK2
name: ketohexokinase (D-xylulose)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.3
type: Reaction
reactant: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is described by: ECO:0000269
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaR PROD2m
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is described by: ECO:0000254
name: Proline dehydrogenase (m)
is version of: http://identifiers.org/ec-code/1.5.99.8
fast: false
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false

metaM bhb c
initial amount: NaN
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
is: CHEBI:10983
constant: false

metaR RE1804C
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1804
is: SBO:0000176

metaM Rtotal3coa c
initial amount: NaN
is: HMDB01448
type: Species
is: SBO:0000247
is: CHEBI:16189
initial concentration: 1.0
name: R total 3 Coenzyme A
constant: false
boundary condition: false
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_bd23348e_1862_4717_8278_8d78e5250d0b
initial amount: NaN
name: _AI971036_1_m
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:AI971036

metaM leuktrF4 e
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: CHEBI:27491
has only substance units: false
is: SBO:0000247
is: HMDB06465
constant: false
initial concentration: 1.0
boundary condition: false
name: leukotriene F4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_189213d7_62c6_4088_aee8_0a135f2caaa5
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:2712
name: GK2
is: Q14410
is: SBO:0000252
initial amount: NaN

metaM 3hdeccoa c
is: HMDB02014
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 3-hydroxyhexadecenoylcoa
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4

metaM prostgd2 c
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
name: prostaglandin D2(1-)
is: SBO:0000247
is: CHEBI:57406
type: Species
constant: false
is: HMDB01403
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR AGMTm
product: MODEL1310110038#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
name: agmatinase (m)
notes: GENE_ASSOCIATION: (79814.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 3.5.3.11 Confidence Level: 4 AUTHORS: PMID:11804860,PMID:11914032,PMID:15028567,PMID:15465778 NOTES:SAB m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.3.11

metaM retinol cis 11 c
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
type: Species
is: CHEBI:16302
has only substance units: false
name: 11-cis-retinol
is: HMDB06216
initial concentration: 1.0

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110038#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_29a61535_b897_4d1c_9053_069f09108732
is encoded by: hsa:594
name: BCKDHB
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: P21953
type: Species
initial concentration: NaN

metaM cgly c
initial amount: NaN
constant: false
initial concentration: 1.0
name: L-cysteinylglycine
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: HMDB00078
is: CHEBI:4047

metaM fn2m2masn g
has only substance units: false
constant: false
initial concentration: 1.0
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
boundary condition: false
initial amount: NaN
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: SBO:0000247
is: CHEBI:32984
type: Species

metaR SPHMYLNtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
name: sphingomyelin intracellular transport
fast: false
reactant: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#

metaM bhb e
type: Species
name: (R)-3-hydroxybutyrate
is: HMDB00011
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:10983
is: SBO:0000247
initial amount: NaN

metaR NDPK7
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dCDP)
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000269
fast: false

metaR FAOXC181C161x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_5ca2a842_e763_44b4_9943_59d81aa1656e
is: P48067
constant: false
name: SLC6A9
is encoded by: hsa:6536
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR r1156
is described by: ECO:0000000
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reactant: MODEL1310110038#
fast: false
type: Reaction
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_60004078_c06f_466a_a60f_5248c1310b98
initial amount: NaN
is: SBO:0000252
name: SLC23A2
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:9962
boundary condition: true
constant: false
is: Q9UGH3

metaR S4TASE1ly
kinetic law: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reactant: MODEL1310110038#
fast: false
is: SBO:0000176
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110038#

metaR ILEt5m
name: Isoleucine mitochondrial transport
reactant: MODEL1310110038#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110038#

metaR KCC2t
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
name: K+-Cl- cotransporter (NH4+)
reactant: MODEL1310110038#
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
type: Reaction

metaM ksi deg12 l
is: CHEBI:12936
initial concentration: 1.0
name: keratan sulfate I, degradation product 12
is: HMDB00143
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
type: Species

metaM hco3 c
boundary condition: false
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
is: C00288
is: HMDB00595
initial amount: NaN
name: Bicarbonate
is: SBO:0000247
is: CHEBI:17544
constant: false
has only substance units: false

metaR r1844
is described by: ECO:0000000
modifier: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110038#
type: Reaction

metaR FAOXC122x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR NDPK6
modifier: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_920bf6ec_4294_4ad7_bbc3_1cc908e8254c
constant: false
has only substance units: false
is encoded by: hsa:57835
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC4A5
type: Species
initial concentration: NaN

metaM glx c
constant: false
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
name: glyoxylate
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:36655
initial amount: NaN

metaM ksii core4 g
constant: false
type: Species
is: CHEBI:17140
initial amount: NaN
name: keratan sulfate II (core 4-linked)
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
is: HMDB01644
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC101C102x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR MDHm
is: SBO:0000176
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
fast: false
name: malate dehydrogenase, mitochondrial

metaM prostgd2 e
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
constant: false
is: CHEBI:57406
is: SBO:0000247
is: HMDB01403
name: prostaglandin D2(1-)

metaR GASNASE3ly
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: glycosylasparaginase, lysosomal
modifier: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_7e5c6848_eb1a_4f2a_81bc_4e850b8ad798
is encoded by: hsa:4712
constant: false
is: O95139
name: NDUFB6
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaM leuktrF4 c
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
has only substance units: false
initial amount: NaN
is: CHEBI:27491
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB06465
constant: false
name: leukotriene F4

metaR APOC LYS BTNP
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
product: MODEL1310110038#
fast: false
name: proteolysis of apoC-Lys-btn
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110038#

metaR CYTK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110038#
name: cytidylate kinase (CMP,CTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110038#
type: Reaction

metaM cgly e
type: Species
is: HMDB00078
boundary condition: false
name: L-cysteinylglycine
is: CHEBI:4047
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_28efa326_2d99_48cc_8ca6_1c2df8bd44bb
initial amount: NaN
name: PDE1C
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: Q8NB10
initial concentration: NaN
constant: false
is encoded by: hsa:5137

metaR G14T6g
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110038#
reactant: MODEL1310110038#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110038#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR r0791
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
product: MODEL1310110038#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM malthp e
has only substance units: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
name: maltoheptaose
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
is: C01936
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837

metaM srtn e
has only substance units: false
is: CHEBI:350546
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN
is: HMDB00259
name: serotonin(1+)
constant: false
type: Species

metaR ACGPID
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.1.89
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false
name: N-acetylglucosaminylphosphatidylinositol deacetylase

metaR NDPK9
reactant: MODEL1310110038#
name: nucleoside-diphosphate kinase (ATP:IDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
modifier: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
fast: false

metaM btamp m
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial amount: NaN
is: HMDB04220
name: Biotinyl-5'-AMP
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:3110
type: Species
has only substance units: false
constant: false

metaM Sfglutth c
name: S-formylglutathionate(1-)
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01550
constant: false
is: CHEBI:57688
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_227a9a1a_fc9d_4cf3_bc32_098e9d2e822c
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: SULT1A1
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6817

metaR FOLt2le
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110038#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110038#

metaR DOPASFt
name: Dopamine 3-0-sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
reactant: MODEL1310110038#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#

metaM ala B m
is: HMDB00056
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
initial amount: NaN
boundary condition: false
constant: false
name: beta-alanine
type: Species

metaR r0792
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
modifier: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_21b9f641_7a0a_4d33_b978_a89b9d87edfe
has only substance units: false
is encoded by: hsa:788
name: SLC25A20
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O43772
constant: false
type: Species

metaR C2tcx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR r1464
is: SBO:0000185
reactant: MODEL1310110038#
name: Active transport
fast: false
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reversible: true

metaM dlnlcg c
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB02925
is: SBO:0000247
name: dihomo-gamma-linolenic acid (n-6)
is: CHEBI:53486
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial amount: NaN

metaR NDPK8
reactant: MODEL1310110038#
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dADP)
fast: false
is: SBO:0000176
product: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110038#

metaM ksii core4 e
type: Species
constant: false
name: keratan sulfate II (core 4-linked)
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
boundary condition: false
is: CHEBI:17268
has only substance units: false
is: HMDB00211
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_cb0d7806_aca1_403e_8d83_af25d8edeebc
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8802
name: SUCLG2:SUCLG1
is encoded by: hsa:8801
has part: Q96I99
initial concentration: NaN
boundary condition: true
has part: P53597
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_cea68994_4d78_498b_9b03_b27c6e46b23e
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10993
name: SDS
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: P20132

metaR NDPK4
name: nucleoside-diphosphate kinase (ATP:dTDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true

metaR SPRMS
name: spermine synthase
type: Reaction
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
kinetic law: MODEL1310110038#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
product: MODEL1310110038#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.22

http://identifiers.org/biomodels.db/MODEL1310110038#_81198073_36dc_4c1a_afba_dd1eb303fe03
is encoded by: hsa:23305
name: ACSL6
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: B2RB13
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b9e8e696_2a49_4a40_b8b7_02146ebf175a
is: O95954
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: FTCD
is encoded by: hsa:10841
has only substance units: false
boundary condition: true

metaR ASCBOX
fast: false
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction
name: ascorbic acid oxidase
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#

metaR FACOAL150
fast: false
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reversible: true
type: Reaction
name: fatty-acid--CoA ligase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_1e43a675_cc62_4c72_bd9e_2dc2ba9b0d4d
is encoded by: hsa:1718
initial amount: NaN
is: Q15392
name: DHCR24
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaM pglyc hs c
has only substance units: false
is: CHEBI:21338
type: Species
is: HMDB02704
initial concentration: 1.0
name: pglyc_hs[c]
notes: FORMULA: CHARGE: 0
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_441ac706_4fe0_4ba3_a679_65845473f93b
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2875
constant: false
name: GPT
is: P24298
type: Species
initial concentration: NaN

metaM dgdp m
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
is: CHEBI:58595
constant: false
name: dGDP(2-)
is: HMDB00960
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM acrn r
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57589
initial concentration: 1.0
has only substance units: false
name: O-acetylcarnitine
initial amount: NaN
constant: false

metaR CORE4GTg
modifier: MODEL1310110038#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
type: Reaction
is: SBO:0000176

metaR ASNCYSNaEx
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110038#
name: L-cysteine/L-asparagine Na-dependent exchange (Asn-L in)
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6510.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2004 (2003), PMID 14530974

metaR r0081
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12

metaR HDCACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM dgsn c
type: Species
is: HMDB00085
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Deoxyguanosine
is: C00330

metaR BTNPL
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
name: holocarboxylase synthestase (biotin protein ligase)

http://identifiers.org/biomodels.db/MODEL1310110038#_3999fc6c_59aa_4187_83be_3bbd22cdc310
has only substance units: false
boundary condition: true
is: P04183
type: Species
is encoded by: hsa:7083
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: TK1

metaR SIAASE2ly
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110038#
fast: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000

metaR NDPK5
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dGDP)
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR TPI
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176
product: MODEL1310110038#
name: triose-phosphate isomerase
reactant: MODEL1310110038#
type: Reaction
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/5.3.1.1
reversible: true
is described by: ECO:0000134
fast: false

metaM oaa c
is: SBO:0000247
type: Species
has only substance units: false
name: Oxaloacetate
is: HMDB00223
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2
initial concentration: 1.0
is: CHEBI:3338
initial amount: NaN
boundary condition: false
constant: false

metaM bilirub c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00054
name: bilirubin(2-)
is: CHEBI:57977
has only substance units: false
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
constant: false
initial concentration: 1.0

metaM rbt c
constant: false
type: Species
is: CHEBI:15963
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
initial concentration: 1.0
is: HMDB00508
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_c85a86bb_75ab_412a_b7ee_6320fbc565c3
initial amount: NaN
is: SBO:0000252
type: Species
is: Q9ULC5
is encoded by: hsa:51703
boundary condition: true
constant: false
has only substance units: false
name: ACSL5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_383e77f3_54b1_4807_875e_46fa4d52f5b4
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q6IBB5
name: NDUFA1
initial amount: NaN
is encoded by: hsa:4694

http://identifiers.org/biomodels.db/MODEL1310110038#_89d7f8b3_40c4_4aec_991a_51b07de4687f
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110038#_be9d7c6a_b7d4_4308_aaef_55b34a96de42
name: MGAT2
constant: false
is encoded by: hsa:4247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q10469

http://identifiers.org/biomodels.db/MODEL1310110038#_9f3bd9ef_cf78_4732_b4f6_e9742d554b09
is: P00374
type: Species
constant: false
is encoded by: hsa:1719
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: DHFR

metaR PYDAMK
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.1.35
product: MODEL1310110038#
type: Reaction
fast: false
name: pyridoxamine kinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110038#
is described by: ECO:0000269
reversible: false

metaR FAOXC102C103x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaM odecrn c
boundary condition: false
name: octadecenoyl carnitine
is: HMDB01114
type: Species
is: SBO:0000247
is: C00412
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57394
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
constant: false
has only substance units: false

metaM 4h2oglt m
type: Species
constant: false
is: SBO:0000247
name: 4-hydroxy-2-oxoglutarate(2-)
is: HMDB02070
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: CHEBI:17742

metaR CGLYt3 2
reactant: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000185
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110038#
type: Reaction
product: MODEL1310110038#

metaR NDPK2
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110038#
reversible: true
is: SBO:0000176
fast: false
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_7e809a39_41f8_48f9_aec5_5450fba713c4
has only substance units: false
name: DCTD
is: P32321
initial amount: NaN
boundary condition: true
is encoded by: hsa:1635
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM ttdca e
constant: false
initial concentration: 1.0
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: C06424
boundary condition: false
is: CHEBI:30807
is: HMDB00806

metaR r0340
type: Reaction
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
fast: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
reversible: false
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38

metaM cholcoar x
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: CHEBI:58677
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: HMDB02178
type: Species

metaM acgam6p c
has only substance units: false
is: HMDB01062
constant: false
initial concentration: 1.0
is: CHEBI:57513
type: Species
is: SBO:0000247
name: N-acetyl-D-glucosamine 6-phosphate(2-)
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357

metaM naglc2p U c
has only substance units: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
type: Species
initial concentration: 1.0
is: CHEBI:18278
boundary condition: false
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: SBO:0000247
constant: false
initial amount: NaN

metaM spmd e
is: CHEBI:57834
has only substance units: false
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
initial amount: NaN
is: HMDB01257
is: SBO:0000247
type: Species
name: Spermidine
initial concentration: 1.0
is: C00315

metaR NDPK3
name: nucleoside-diphosphate kinase (ATP:CDP)
type: Reaction
reversible: true
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR TETTET6COAtx
is described by: ECO:0000000
name: fatty acid intracellular transport
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
reactant: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110038#_9f08aa63_c147_483b_8d76_2ee5cdb2144e
type: Species
name: UPP1
is encoded by: hsa:7378
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM dgdp n
type: Species
constant: false
boundary condition: false
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58595
has only substance units: false
initial amount: NaN
is: HMDB00960

metaM rbt e
has only substance units: false
is: CHEBI:15963
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial concentration: 1.0
name: D-ribitol
constant: false
type: Species

metaM ksi deg21 l
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 21
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: SBO:0000247
is: HMDB00143
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:12936

metaR MALTSULtm
name: Malate:thiosulfate antiport, mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction

metaR NDPK10n
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110038#
reversible: true
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
fast: false
is: SBO:0000176
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear

metaM 5eipencoa m
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
type: Species
name: 5,8,11,14,17-eicosapentenoylcoa
is: SBO:0000247
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
initial concentration: 1.0

metaM hexdiac r
type: Species
notes: FORMULA: C16H28O4 CHARGE: -2
is: HMDB00672
constant: false
name: hexadecanediocacid
boundary condition: false
is: C08260
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_bb077609_eb95_416a_8ef0_97c4a1d9fd71
initial concentration: NaN
is: SBO:0000252
name: ENPP3
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:5169
constant: false
is: Q308M7

http://identifiers.org/biomodels.db/MODEL1310110038#_2a5b95e3_3ddc_4817_a982_5f2500938db2
is encoded by: hsa:6818
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: SULT1A3
initial amount: NaN
is: SBO:0000252
is: P50224
has only substance units: false

metaR GLYt7 311 r
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000006
modifier: MODEL1310110038#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR KSItly
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110038#
name: keratan sulfate I transport, extracellular to lysosome
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110038#_3ff08d46_9f45_4496_b8fe_ecf3b629ea7b
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:224
name: ALDH3A2
is: P51648
type: Species
initial concentration: NaN
constant: false

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
is: CHEBI:3303
initial concentration: 1.0
is: SBO:0000247
name: H2O
has only substance units: false
boundary condition: false
is: HMDB02111
initial amount: NaN
is: C00001
type: Species
constant: false

metaR r2394
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_cb886224_16f6_4756_94d9_12db8e5c7f94
initial amount: NaN
boundary condition: true
is encoded by: hsa:1109
is: P17516
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: AKR1C4
constant: false

metaR DHORTS
kinetic law: MODEL1310110038#
name: dihydroorotase
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is described by: ECO:0000269
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaR SEBCOACROT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR TYRTA
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
modifier: MODEL1310110038#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110038#
fast: false

metaR HOCTDECCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR r0085
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
product: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
is: SBO:0000176

metaM ppa c
is: SBO:0000247
constant: false
is: HMDB00237
initial concentration: 1.0
boundary condition: false
is: CHEBI:17272
name: propionate
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
type: Species
has only substance units: false

metaM cit e
is: CHEBI:16947
initial concentration: 1.0
name: citrate(3-)
initial amount: NaN
is: HMDB00094
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_fb1a9f6a_63af_4643_a3de_3e6de6a6a686
type: Species
initial amount: NaN
is encoded by: hsa:6241
initial concentration: NaN
has only substance units: false
name: RRM2
is: SBO:0000252
constant: false
is: P31350
boundary condition: true

metaR AMETtd
fast: false
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: diffusion of S-Adenosyl-L-methionine
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_170be5af_f899_49a8_9bbe_8f7bd98a244d
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: BAAT
is: Q14032
is encoded by: hsa:570

http://identifiers.org/biomodels.db/MODEL1310110038#_c36ec4ce_5a7b_4e0c_9e31_73ba93b4b3b9
is encoded by: hsa:197257
initial concentration: NaN
has only substance units: false
name: LDHD
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaM 2hb e
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
is: SBO:0000247
is: CHEBI:1148
initial concentration: 1.0
initial amount: NaN
name: 2-Hydroxybutyrate
has only substance units: false
constant: false
boundary condition: false

metaR NDPK1
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:GDP)
is: SBO:0000176
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_f09cad26_4f05_4daf_9aef_ac2c508b3e56
has only substance units: false
name: SLC6A3
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: Q01959
constant: false
is encoded by: hsa:6531
initial concentration: NaN

metaR ILETA
reversible: true
fast: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: isoleucine transaminase
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
is described by: ECO:0000269

metaR AGTim
reactant: MODEL1310110038#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.44

http://identifiers.org/biomodels.db/MODEL1310110038#_fcf051a0_2ba1_4d7d_9abd_71355391fca8
has only substance units: false
constant: false
name: OGDH
is encoded by: hsa:4967
is: Q02218
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

metaM ncam c
is: HMDB01406
is: CHEBI:0
is: SBO:0000247
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
is: C00153
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM decdicrn c
notes: FORMULA: C17H29NO4 CHARGE: 0
name: decadienoyl carnitine
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB13325
initial concentration: 1.0

metaR GASNASEly
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110038#
name: glycosylasparaginase, lysosomal

metaR GALASE15ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110038#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is: SBO:0000176
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM dolmanp L c
has only substance units: false
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15809
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
type: Species

metaR FUCASE2ly
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, lysosomal
product: MODEL1310110038#
type: Reaction

metaR r0236
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
type: Reaction
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.1.6
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#

metaR CITt4 4
product: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
kinetic law: MODEL1310110038#
is: SBO:0000185
name: citrate transport via sodium symport
type: Reaction
is described by: ECO:0000006
modifier: MODEL1310110038#
fast: false
reactant: MODEL1310110038#

metaR FAOXC141C121x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaR r0084
type: Reaction
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110038#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR SERGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
name: L-Serine/Glycine reversible exchange
reactant: MODEL1310110038#
is described by: ECO:0000304
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
fast: false
product: MODEL1310110038#
type: Reaction

metaR GALASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110038#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110038#

metaM glu5p m
is: CHEBI:58274
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01228
initial concentration: 1.0
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
name: L-Glutamate 5-phosphate
constant: false
boundary condition: false

metaR FAOXC150m
reversible: false
reactant: MODEL1310110038#
modifier: MODEL1310110038#
fast: false
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110038#_0a8bfe22_a3d6_4d4e_b2d1_cb5ec37eeafd
is encoded by: hsa:10840
name: ALDH1L1
is: O75891
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

metaR RE3243R
modifier: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
name: RE3243
fast: false
type: Reaction
product: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_7bb57dd3_4021_49f9_8995_de429437485d
constant: false
type: Species
name: DBT
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P11182
is encoded by: hsa:1629
initial amount: NaN

metaM ahdt e
is: CHEBI:58462
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
initial amount: NaN
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
boundary condition: false
is: SBO:0000247
is: HMDB00980
constant: false
type: Species

metaR r0083
fast: false
is: SBO:0000176
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction

metaM c101crn e
is: HMDB13205
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C17H31NO4 CHARGE: 0
name: decenoyl carnitine
is: SBO:0000247

metaR RETHe
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
reversible: false
fast: false
name: retinyl ester hydrolase, extracellular
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

metaR r0196
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false

metaM cit c
is: HMDB00094
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
is: CHEBI:16947
name: Citrate

metaR r2395
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000

metaM 2hb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
is: HMDB00008
is: CHEBI:1148
is: SBO:0000247
name: 2-Hydroxybutyrate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaM aacoa m
initial concentration: 1.0
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
name: acetoacetyl-CoA(4-)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57286

http://identifiers.org/biomodels.db/MODEL1310110038#_a7c23c0c_4282_4880_8111_aea22323bcab
name: TPI1P2
constant: false
initial amount: NaN
is encoded by: hsa:286016
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 3hodcoa c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
initial concentration: 1.0
is: HMDB13336
type: Species
name: (S)-3-Hydroxyoctadecanoyl-CoA

metaM decdicrn e
initial concentration: 1.0
notes: FORMULA: C17H29NO4 CHARGE: 0
is: SBO:0000247
name: decadienoyl carnitine
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB13325
boundary condition: false

metaR r0082
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.2
is: SBO:0000176
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_c619a8e0_9584_4204_9e6a_484d0f70319b
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: TAT
is: SBO:0000252
is: P17735
type: Species
is encoded by: hsa:6898
initial amount: NaN

metaR SBCOAACOTx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR BACCLm
reversible: false
modifier: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is: SBO:0000176
reactant: MODEL1310110038#
is described by: ECO:0000254
fast: false

metaM aicar c
is: C04677
has only substance units: false
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
is: CHEBI:58475
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01517
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: SBO:0000247

metaR FAOXC102C103m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR CERT2gt
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
modifier: MODEL1310110038#

metaM octdececoa c
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: octadecenoylcoa
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: HMDB06351

metaR GLUVESSEC
notes: GENE_ASSOCIATION: (57084.1) or (246213.1) or (57030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11432869,PMID:12811560,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of glu from the cell. It leaves out the vesicle because a compartment is not available for that. ATP demand is not known stoichiometrically.
product: MODEL1310110038#
fast: false
is described by: ECO:0000269
name: L-glutamate secretion via secretory vesicle (ATP driven)
reversible: false
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_a9b155e4_5baf_4d37_ac9f_fd3dec43cf26
boundary condition: true
is: SBO:0000252
is encoded by: hsa:728441
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: GGT2
initial concentration: NaN

metaR RE3565C
reactant: MODEL1310110038#
product: MODEL1310110038#
reversible: true
name: RE3565
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR ADK3m
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
reactant: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
fast: false
modifier: MODEL1310110038#
reversible: true
name: adentylate kinase (GTP)
kinetic law: MODEL1310110038#

metaR S23Tg
modifier: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.4
reversible: false
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
kinetic law: MODEL1310110038#
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)

http://identifiers.org/biomodels.db/MODEL1310110038#_b4e58d5d_c8dd_42d0_a735_e347dd7134c6
is: SBO:0000252
name: LDHD
boundary condition: true
type: Species
is encoded by: hsa:197257
initial amount: NaN
is: Q86WU2
constant: false
initial concentration: NaN
has only substance units: false

metaR KCCt
kinetic law: MODEL1310110038#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: K+-Cl- cotransport
reactant: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
product: MODEL1310110038#
modifier: MODEL1310110038#

metaR NMNATr
product: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110038#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1

metaM h2o g
is: HMDB02111
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15377
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
name: water

metaR LYSOXp
reactant: MODEL1310110038#
is: SBO:0000176
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM

metaM msa m
boundary condition: false
is: SBO:0000247
name: 3-oxopropanoate
initial concentration: 1.0
is: HMDB11111
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:33190

metaR DOLPMT1 Uer
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.258
product: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
type: Reaction
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110038#_5c5dfae5_6f96_43af_badf_9d2da8631bd1
name: COASY
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q13057
is encoded by: hsa:80347
constant: false
initial concentration: NaN

metaR r0193
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
product: MODEL1310110038#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
fast: false

metaR XANtx
name: xanthine diffusion in peroxisome
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR TAURt4 2 r
product: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110038#
name: taurine transport (sodium symport) (2:1)
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (6533.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_c34d8510_a175_412d_8809_d2d8d5392220
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P45954
is encoded by: hsa:36
constant: false
is: SBO:0000252
name: ACADSB
has only substance units: false
type: Species

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.99.13
type: Reaction
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: true
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is described by: ECO:0000000
fast: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
constant: false
is: HMDB02329
initial amount: NaN
boundary condition: false
is: CHEBI:30623
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR TYRTAm
notes: GENE_ASSOCIATION: (6898.1) or (2806.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: PMID:1973834 NOTES:NCD
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.5
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
name: tyrosine transaminase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110038#_0b317590_e933_4063_bf3a_f9749d8b1d22
initial amount: NaN
is encoded by: hsa:4143
type: Species
has only substance units: false
is: Q00266
constant: false
name: MAT1A
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_3b49b4ef_cb8d_4a5b_80ed_71f58201d493
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
name: RPE
is encoded by: hsa:6120
is: Q53TV9
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_d3c6ab1c_cede_4480_9ca9_c4a448556f75
initial amount: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
name: KL
is: SBO:0000252
is: Q9UEF7
initial concentration: NaN
is encoded by: hsa:9365

metaM ksi pre22 g
name: keratan sulfate I biosynthesis, precursor 22
is: SBO:0000247
boundary condition: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
constant: false
is: CHEBI:58053
has only substance units: false
is: HMDB00175
is: C00130
initial amount: NaN
initial concentration: 1.0
type: Species

metaM aicar e
is: C04677
boundary condition: false
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
constant: false
is: CHEBI:58475
initial amount: NaN
is: HMDB01517
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2

metaM dmpp x
is: SBO:0000247
is: CHEBI:57623
is: HMDB01120
has only substance units: false
name: prenyl diphosphate(3-)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235

http://identifiers.org/biomodels.db/MODEL1310110038#_d9a82439_3a6a_4989_9161_d5cbb36291ee
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:226
initial amount: NaN
name: ALDOA
type: Species

metaM cyan m
is: SBO:0000247
initial concentration: 1.0
is: HMDB02084
name: hydrogen cyanide
constant: false
is: CHEBI:18407
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326

http://identifiers.org/biomodels.db/MODEL1310110038#_2d0db410_b63b_40c8_bf40_8cfc8e34bf11
initial amount: NaN
initial concentration: NaN
type: Species
is: B3KN25
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10390
constant: false
name: CEPT1
has only substance units: false

metaR DADNK
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: deoxyadenosine kinase
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.76 Confidence Level: 4 AUTHORS: PMID:6317685 NOTES:Deoxyguanosine can also act as acceptor. Possibly identical with EC 2.7.1.74 deoxycytidine kinase.
fast: false
reactant: MODEL1310110038#

metaR SUBERCROT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaR r1018
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
type: Reaction
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#

metaR ST8SIA12
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_929ee10e_edef_4c32_ad13_f277318bb2e2
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2954
initial concentration: NaN
name: GSTZ1

metaM h2o e
initial amount: NaN
boundary condition: false
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
is: SBO:0000247
is: CHEBI:15377
constant: false
is: C00001
initial concentration: 1.0
name: H2O

metaR CSPG Etly
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110038#
name: chondroitin sulfate E transport, extracellular to lysosome
type: Reaction

metaM btamp c
name: Biotinyl-5'-AMP
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3110
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
constant: false
has only substance units: false
is: HMDB04220
type: Species

metaM acrn x
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: O-acetylcarnitine
boundary condition: false
is: CHEBI:57589
type: Species
is: HMDB00201
has only substance units: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

metaR r0191
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.24
modifier: MODEL1310110038#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110038#_8e2283b0_a885_4df6_85a4_12ddc9afee9d
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q67FW5
is encoded by: hsa:146712
is: SBO:0000252
name: B3GNTL1
initial amount: NaN
boundary condition: true

metaR r0086
fast: false
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110038#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_3fec113c_413a_4b55_8666_b0de6d8281f9
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55268
boundary condition: true
constant: false
is: SBO:0000252
name: ECHDC2
is: Q86YB7

metaM hcys L c
is: CHEBI:17588
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
constant: false
has only substance units: false
is: HMDB00742
is: SBO:0000247
initial amount: NaN
type: Species
name: L-homocysteine
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_db674c57_643b_4cf5_bd14_08974573d52b
initial concentration: NaN
type: Species
is: Q9H936
is encoded by: hsa:79751
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC25A22

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM tmndnc e
is: http://identifiers.org/pubchem.compound/446284
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: HMDB01999
name: timnodonic acid C20:5, n-3

metaM ncam e
type: Species
name: Nicotinamide
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01406
has only substance units: false
notes: FORMULA: C6H6N2O CHARGE: 0
initial amount: NaN
is: CHEBI:0
initial concentration: 1.0
is: C00153

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM oaa m
is: SBO:0000247
is: C00036
name: Oxaloacetate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223
type: Species
is: CHEBI:16452
has only substance units: false

metaR r1019
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction

metaM hx2coa x
boundary condition: false
is: HMDB06870
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial amount: NaN
is: C05998
type: Species
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false

metaM akg e
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: HMDB00208
constant: false
boundary condition: false
is: CHEBI:16810

metaR OCDEAFABP1tc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of octadecenoyl coA into the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_6c924fb9_85c1_49b8_a047_61fac21b5eb6
is: SBO:0000252
is encoded by: hsa:AI697028
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI697028_1_e
type: Species
has only substance units: false

metaM cit m
name: Citrate
initial amount: NaN
boundary condition: false
is: HMDB00094
type: Species
is: C00158
is: CHEBI:16947
constant: false
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
initial concentration: 1.0

metaR r1581
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#

metaM h2o l
boundary condition: false
name: water
initial concentration: 1.0
is: HMDB02111
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_d61bb90e_e06e_49dc_b16c_e5f78db9c4e4
type: Species
initial amount: NaN
name: _AI926493_1_c
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI926493
is: SBO:0000252
initial concentration: NaN

metaR NTP3e
name: nucleoside-triphosphatase (GTP)
reversible: false
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
product: MODEL1310110038#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.6

metaM aacoa x
initial concentration: 1.0
name: acetoacetyl-CoA(4-)
boundary condition: false
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: SBO:0000247
is: CHEBI:57286
constant: false
initial amount: NaN
is: HMDB01484

metaR S6T2g
reversible: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_2ba37e39_fe5c_4d4a_9e8d_b2f33d90e93d
initial amount: NaN
is encoded by: hsa:5053
is: SBO:0000252
boundary condition: true
name: PAH
has only substance units: false
is: P00439
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_d960feb5_bb72_470b_a1cd_eb4905335c6c
constant: false
boundary condition: true
is: Q6FHI7
has only substance units: false
name: CA4
type: Species
initial amount: NaN
is encoded by: hsa:762
initial concentration: NaN
is: SBO:0000252

metaM h2o m
constant: false
type: Species
is: HMDB02111
name: H2O
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C00001
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0

metaR GRTTx
reversible: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
is described by: ECO:0000134
name: geranyltranstransferase
fast: false
type: Reaction
reactant: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM amp c
is: SBO:0000247
is: C00020
is: CHEBI:3322
has only substance units: false
constant: false
is: HMDB00045
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP

metaM T4hcinnm m
boundary condition: false
constant: false
is: CHEBI:12876
name: trans-4-coumarate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02035

metaR RE2626C
name: RE2626
product: MODEL1310110038#
reversible: true
fast: false
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110038#

metaM stcrn c
constant: false
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
type: Species
initial concentration: 1.0
boundary condition: false
name: stearoylcarnitine
has only substance units: false
initial amount: NaN
is: HMDB00848
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_286d9edd_ab66_4486_bcf5_8727458d9449
has only substance units: false
name: LALBA
initial amount: NaN
boundary condition: true
is: P00709
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:3906
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_232d80f9_984f_4f95_bcd1_26a4bf2fef53
is: Q08499
is encoded by: hsa:5144
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: PDE4D
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM tmndnc c
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/446284
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
is: SBO:0000247
constant: false
name: timnodonic acid C20:5, n-3
is: HMDB01999
initial amount: NaN

metaR CSNAT3x
reversible: true
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: carnitine O-aceyltransferase, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ

metaM pail3p hs c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial amount: NaN
boundary condition: false
is: CHEBI:58088
initial concentration: 1.0
constant: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)

metaM akg c
is: CHEBI:16810
boundary condition: false
is: SBO:0000247
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
constant: false
has only substance units: false
name: 2-Oxoglutarate
is: HMDB00208
initial amount: NaN
type: Species

metaR CHOLATEt
is described by: ECO:0000269
fast: false
product: MODEL1310110038#
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
reversible: true
modifier: MODEL1310110038#

metaM 3octpencoa m
name: 3,6,9,12,15-octadecapentenoylcoa
is: SBO:0000247
constant: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaM man6p c
has only substance units: false
initial amount: NaN
is: HMDB01078
constant: false
name: D-Mannose 6-phosphate
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:17369

http://identifiers.org/biomodels.db/MODEL1310110038#_3ed7878c_b746_4903_bd2f_969880873b2a
name: CMAS
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q8NFW8
is encoded by: hsa:55907
is: SBO:0000252
has only substance units: false

metaR GLCAASE4ly
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110038#
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110038#_730e2b24_37c9_480a_9963_d9f52cda3c13
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: IDI1
is: Q13907
is encoded by: hsa:3422

metaR MANtly
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000000
name: mannose efflux from lysosome
type: Reaction
product: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_8117eddf_66f7_485f_92ed_60ec88c6c9dd
initial concentration: NaN
is: Q9UMR5
constant: false
type: Species
boundary condition: true
name: PPT2
initial amount: NaN
has only substance units: false
is encoded by: hsa:9374
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_b15b5f9b_c535_4b12_af25_d23d7ad4a6b9
is encoded by: hsa:57419
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: Q9HC58
name: SLC24A3
constant: false
is: SBO:0000252
boundary condition: true

metaM dgdp c
is: HMDB00960
is: CHEBI:58595
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: C00361
constant: false
type: Species
name: dGDP

metaR PRISTCOAtcx
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR BDMT U
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.142
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:3454
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01338
is: SBO:0000247
has only substance units: false
is: C00154

http://identifiers.org/biomodels.db/MODEL1310110038#_1426dacd_741f_4b70_9efb_520bcd14d0f1
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: Q96RQ3
type: Species
is: SBO:0000252
name: MCCC1
is encoded by: hsa:56922
boundary condition: true

metaM CE5160 r
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
constant: false
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3-oxo-cis-9-octadecenoyl-CoA
type: Species

metaM amp e
name: AMP
constant: false
is: HMDB00045
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
is: CHEBI:456215
is: C00020

metaR UAG2EMAi
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/5.1.3.14
is: SBO:0000176
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
is described by: ECO:0000269
fast: false

metaR r1580
kinetic law: MODEL1310110038#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
reversible: true
type: Reaction
is: SBO:0000185

metaM bilirub e
constant: false
name: bilirubin(2-)
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
initial amount: NaN
is: CHEBI:57977
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

metaM tetdec2coa c
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02014
boundary condition: false
name: tetradecadienoylcoa
initial amount: NaN

metaR ATP1ter
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110038#
name: ADP/ATP transporter, endoplasmic reticulum
product: MODEL1310110038#
is described by: ECO:0000000
type: Reaction

metaR THMDt4
fast: false
name: thymidine transport in via sodium symport
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB

metaM tym c
initial concentration: 1.0
boundary condition: false
is: CHEBI:327995
has only substance units: false
type: Species
name: tyraminium
constant: false
is: SBO:0000247
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
is: HMDB00306
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_40327e95_66a1_4e6b_a6a2_e2018cf16f61
constant: false
boundary condition: true
name: HADHA:HADHB
initial amount: NaN
is encoded by: hsa:3030
has part: E9KL44
is encoded by: hsa:3032
has part: P55084
is: SBO:0000297
type: Species
initial concentration: NaN
has only substance units: false

metaM ocdca e
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
is: SBO:0000247
initial concentration: 1.0
is: C01530
has only substance units: false
name: octadecanoate (n-C18:0)
constant: false

metaR LNELDCCRNt
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
name: transport into the mitochondria (carnitine)
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_38423a16_285e_41d0_979d_b545c5e1a2e4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:LOC727762
initial amount: NaN
boundary condition: true
name: _LOC727762_1_m

metaR CO2tp
reversible: true
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: CO2 peroxisomal transport
fast: false
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_194694dd_b2a6_4a34_8885_83dc12eb3d1d
constant: false
boundary condition: true
is: P31040
initial amount: NaN
is encoded by: hsa:6389
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SDHA

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaR r1586
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110038#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_d72adc67_53d2_454b_851e_c2c18c16d99e
boundary condition: true
constant: false
initial amount: NaN
is: P19404
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NDUFV2
is encoded by: hsa:4729

metaM HC01434 m
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58931

http://identifiers.org/biomodels.db/MODEL1310110038#_59938381_fe55_45da_9b3c_246955b31b84
is encoded by: hsa:6901
has only substance units: false
is: Q16635
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: TAZ
boundary condition: true
constant: false

metaR S4TASE2ly
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
modifier: MODEL1310110038#
fast: false
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
name: N-acetylgalactosamine-4-sulfatase, lysosomal

metaR HTDCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR C140CPT1
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR r1012
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
reversible: false
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
fast: false

metaM dhf m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
constant: false
type: Species
boundary condition: false
is: CHEBI:57451
is: SBO:0000247
name: dihydrofolate(2-)

metaM cyan c
is: SBO:0000247
is: CHEBI:18407
name: hydrogen cyanide
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
type: Species

metaM biocyt c
has only substance units: false
is: C05552
constant: false
boundary condition: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB03134
name: Biocytin
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_7290c8af_3b34_4403_bb60_3f4ba3cc55a2
name: _AI971036_1_x
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AI971036
has only substance units: false

metaR r1585
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#

metaR FAOXC61C4m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_6188e529_5043_4cd4_a4f6_644ee037902c
initial amount: NaN
is: O00217
type: Species
initial concentration: NaN
constant: false
name: NDUFS8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4728
boundary condition: true

metaM ocdca c
has only substance units: false
is: HMDB00827
is: SBO:0000247
name: stearate
is: CHEBI:25629
initial amount: NaN
boundary condition: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
type: Species
constant: false

metaM core6 l
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:12936
name: Core 6

metaR r1011
reactant: MODEL1310110038#
reversible: false
type: Reaction
name: Transport reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM glyb c
name: glycine betaine
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: CHEBI:17750
is: HMDB00043
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM dolmanp L r
has only substance units: false
type: Species
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: CHEBI:15809
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_30be444e_45a8_48dd_9408_dc0e878fd3a4
constant: false
is: SBO:0000252
name: ADH1A
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:124
type: Species
initial concentration: NaN
is: P07327

http://identifiers.org/biomodels.db/MODEL1310110038#_7561a447_498c_4a89_afa2_97a88e099af3
name: AHCY
boundary condition: true
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: B3KUN3
is encoded by: hsa:191
initial amount: NaN
initial concentration: NaN

metaR DM fol
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110038#
reversible: true
type: Reaction
fast: false
name: cytidylate kinase (CMP,UTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM octe5coa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa
boundary condition: false

metaR r1584
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
type: Reaction
is: SBO:0000185

metaR METAT
notes: GENE_ASSOCIATION: (4143.1) or (27430.2 and 4144.1) or (27430.1 and 4144.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.5.1.6
modifier: MODEL1310110038#
fast: false
reversible: false
name: methionine adenosyltransferase
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_b6274830_7588_48e6_b29e_421b75ee2848
name: _AW299740_1_m
is: SBO:0000252
is encoded by: hsa:AW299740
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR r1010
name: Postulated transport reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d873c88a_e766_4af9_ab75_cd909a3bcf18
is encoded by: hsa:5740
is: Q16647
type: Species
name: PTGIS
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaM C05280 m
is: HMDB03952
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
name: cis,cis-3,6-Dodecadienoyl-CoA
is: CHEBI:28002
type: Species

metaR FAOXC161802m
name: Beta oxidation fatty acid
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110038#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110038#

metaM h2o n
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: water
is: CHEBI:15377
is: HMDB02111
initial amount: NaN
is: SBO:0000247

metaM cyan e
is: CHEBI:18407
initial amount: NaN
constant: false
boundary condition: false
name: hydrogen cyanide
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
is: HMDB02084
type: Species

metaR r1583
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110038#
reversible: true
fast: false
product: MODEL1310110038#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM cholate e
is: SBO:0000247
has only substance units: false
is: CHEBI:29747
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
type: Species
initial concentration: 1.0
constant: false
is: HMDB00619
initial amount: NaN

metaR GALASE12ly
fast: false
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_051b28a6_b9f1_4362_82ae_bf38fa570f09
is: SBO:0000252
type: Species
initial amount: NaN
name: NDUFA5
is encoded by: hsa:4698
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is: Q16718

http://identifiers.org/biomodels.db/MODEL1310110038#_18b501c0_68ae_486f_bf41_7e09de55b580
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6574
initial concentration: NaN
constant: false
boundary condition: true
is: Q8WUM9
initial amount: NaN
name: SLC20A1

http://identifiers.org/biomodels.db/MODEL1310110038#_8d3fa2bf_1e0c_4aa9_98a4_810632342add
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4124
constant: false
has only substance units: false
initial amount: NaN
name: MAN2A1
boundary condition: true
type: Species
is: Q16706

metaR r2537
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110038#
reversible: true
fast: false
kinetic law: MODEL1310110038#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110038#_7a839f1c_e4e4_4daa_8e92_a5579c5910f0
is encoded by: hsa:NOS2A
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: _NOS2A_1_e

metaM hexdiac c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00672
boundary condition: false
name: hexadecanediocacid
is: C08260
type: Species
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
has only substance units: false
constant: false

metaR G14T14g
is: SBO:0000176
modifier: MODEL1310110038#
product: MODEL1310110038#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR 41R1H2MAE12BOOX
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
reversible: false
reactant: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.4
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
is: SBO:0000176
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
fast: false

metaR BCRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_e8ddae84_5940_4378_8300_b452c16d0ab4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10797
name: MTHFD2
type: Species
initial amount: NaN
is: P13995
constant: false

metaR C181CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
reactant: MODEL1310110038#
product: MODEL1310110038#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
is: SBO:0000176

metaM nadh m
is: C00004
initial concentration: 1.0
is: HMDB01487
constant: false
initial amount: NaN
type: Species
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM sT antigen g
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
is: CHEBI:16565
boundary condition: false
name: sialyl-T antigen
initial amount: NaN

metaR TYROXDAc
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110038#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110038#_3dd972eb_839a_4333_bc0f_bc2c8170f943
is encoded by: hsa:3101
constant: false
is: P52790
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: HK3
boundary condition: true

metaM hdcoa m
name: Hexadecenoyl-CoA (n-C16:1CoA)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: HMDB06532
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR FAOXC103C102x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaM man l
name: D-mannose
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: CHEBI:16024
is: SBO:0000247

metaM ksi deg40 l
type: Species
boundary condition: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C40H68N2O31 CHARGE: 0
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 40
is: CHEBI:12936

metaM gam6p c
is: SBO:0000247
type: Species
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
name: D-Glucosamine 6-phosphate
is: CHEBI:12962
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01254
constant: false
has only substance units: false

metaR CO2tm
is described by: ECO:0000000
reversible: true
name: CO2 transport (diffusion), mitochondrial
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
fast: false
is: SBO:0000185
type: Reaction

metaM ump c
constant: false
is: HMDB00288
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: UMP
is: SBO:0000247
is: C00105
is: CHEBI:57865
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110038#_78978a49_d602_4af4_8c68_26032fa65ea6
is encoded by: hsa:8574
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: O43488
constant: false
name: AKR7A2
type: Species

metaR PI4PLC
fast: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110038#
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.1.4.11

metaR RE1233C
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110038#
name: RE1233
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_554c9ca8_7575_46ce_a6fa_c2e37b774ac9
is: Q9BQG2
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: NUDT12
has only substance units: false
is encoded by: hsa:83594

metaM Nacasp m
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: HMDB00812
type: Species
boundary condition: false
initial concentration: 1.0
name: N-acetyl-L-aspartate(2-)

metaR r1589
kinetic law: MODEL1310110038#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110038#

metaM HC02206 e
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57399
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin C1(1-)
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

metaM cholate c
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
initial amount: NaN
initial concentration: 1.0
name: Cholate
is: CHEBI:29747
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaM ksi deg27 l
has only substance units: false
is: HMDB00143
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 27
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false
constant: false
type: Species
notes: FORMULA: C104H169N7O88S4 CHARGE: -4

metaR r2538
product: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaM akg m
type: Species
has only substance units: false
name: 2-Oxoglutarate
initial concentration: 1.0
is: CHEBI:16810
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: C00026
initial amount: NaN
is: HMDB00208
constant: false
is: SBO:0000247

metaM retinal cis 9 r
is: CHEBI:17898
type: Species
name: all-trans-retinal
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
initial concentration: 1.0
is: HMDB01358
initial amount: NaN

metaR GASNASE2ly
is described by: ECO:0000000
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#

metaR C181CPT1
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110038#
name: transport of Octadecenoyl-CoA into mitochondrial matrix
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is: SBO:0000176

metaR r2535
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110038#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
fast: false
reactant: MODEL1310110038#

metaR NRVNCt
name: fatty acid transport via diffusion
is described by: ECO:0000000
reactant: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR r1588
reversible: true
fast: false
kinetic law: MODEL1310110038#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000000

metaM acrn c
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57589
name: O-acetylcarnitine
is: HMDB00201
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

http://identifiers.org/biomodels.db/MODEL1310110038#_df4d04f2_8eb0_4127_9226_75c1c817014f
name: ETFA
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:2108
initial amount: NaN
is: P13804
is: SBO:0000252
boundary condition: true

metaR AG13T1g
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
fast: false
kinetic law: MODEL1310110038#
is described by: ECO:0000000
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_ceb998c7_1f05_46c0_970e_b3e7469cf50b
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1337
initial concentration: NaN
is: P12074
name: COX6A1
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_23124fd0_05a9_45ef_831d_99b57209ae5f
name: _R39999_1_c
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:R39999
has only substance units: false
initial amount: NaN
boundary condition: true

metaR 3AIBt
is: SBO:0000185
reversible: false
reactant: MODEL1310110038#
name: 3-amino-isobutyrate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
product: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_a28a67b6_8e65_4893_8dde_5f05054e4348
name: SLC16A2
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:6567
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: P36021

metaM ura c
type: Species
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial amount: NaN
is: HMDB00300
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17568
boundary condition: false
name: Uracil
is: C00106
constant: false

metaR KHK
is: SBO:0000176
fast: false
type: Reaction
reversible: false
product: MODEL1310110038#
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110038#
name: ketohexokinase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.3

http://identifiers.org/biomodels.db/MODEL1310110038#_d98ebddd_bc08_4e51_8581_6419d69abc63
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: VNN3:VNN2:VNN1
has only substance units: false
is encoded by: hsa:55350
type: Species
constant: false

metaM HC02206 c
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57399
name: prostaglandin C1(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false

metaM h2o r
has only substance units: false
is: HMDB02111
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C00001
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial concentration: 1.0
constant: false
name: H2O
is: CHEBI:15377

metaR r1587
fast: false
reversible: true
product: MODEL1310110038#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
is described by: ECO:0000000
is: SBO:0000185

metaR HTDCACBP
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR CYANtm
name: Cyanide transport via diffusion (mitochondrial)
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
is described by: ECO:0000000

metaR DOLPMT U
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
reversible: false
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110038#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_cd09f359_4198_4025_a011_056fdf573845
is: SBO:0000252
is encoded by: hsa:9058
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: SLC13A2
is: E7ETH5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_7e782902_c1c9_4956_83fd_cffeacc0cb40
is encoded by: hsa:9415
constant: false
name: FADS2
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O95864
initial concentration: NaN
has only substance units: false

metaM ha pre1 l
constant: false
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_aaf563ab_d420_4233_b9cf_0c0e6e0e0a8d
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: PLCD3
is: Q8N3E9
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:113026

http://identifiers.org/biomodels.db/MODEL1310110038#_7c09577d_a043_4280_84a1_5f32da689f07
type: Species
has only substance units: false
name: SULT1A2
is encoded by: hsa:6799
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR GALt1r
reversible: true
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
name: galactose transport (uniport)
fast: false
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#

metaM pi c
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00973
boundary condition: false
name: hydrogenphosphate
type: Species
is: CHEBI:43474
initial concentration: 1.0
is: C00009
notes: FORMULA: HO4P CHARGE: -2
is: SBO:0000247

metaM pmtcoa m
has only substance units: false
is: CHEBI:57379
is: HMDB01338
is: C00154
initial amount: NaN
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial concentration: 1.0
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
type: Species

metaM c101crn c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H31NO4 CHARGE: 0
is: SBO:0000247
name: decenoyl carnitine
is: HMDB13205
boundary condition: false
constant: false
initial amount: NaN
type: Species

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaM CE4876 r
type: Species
constant: false
name: delta12-Prostaglandin J2
has only substance units: false
boundary condition: false
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247
initial concentration: 1.0

metaR ASPTAm
reversible: true
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
type: Reaction
name: aspartate transaminase
is: SBO:0000176
reactant: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_9b5e8329_144f_4736_a1de_c7aab84217d3
type: Species
is: P04746
name: AMY2A
has only substance units: false
constant: false
is encoded by: hsa:279
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR CLFORtex
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000185
name: chloride transport via formate countertransport
is described by: ECO:0000304
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
product: MODEL1310110038#

metaR DOLPMT2 Uer
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
fast: false
reactant: MODEL1310110038#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaM h2o x
type: Species
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
has only substance units: false
is: C00001
initial amount: NaN
name: H2O
is: HMDB02111
boundary condition: false
is: CHEBI:15377
is: SBO:0000247

metaM so3 m
type: Species
boundary condition: false
is: CHEBI:17137
has only substance units: false
is: HMDB00240
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: hydrogensulfite
is: SBO:0000247

metaR C5DCe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaR LINKDEG2ly
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: degradation of proteoglycan linkage region, lysosomal

metaR RE2625M
kinetic law: MODEL1310110038#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE2625
modifier: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
reactant: MODEL1310110038#

metaR ACETONEt2m
reversible: true
is: SBO:0000185
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: acetone mitochondrial transport via proton symport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false

metaR r2534
reactant: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: true
is: SBO:0000185

metaR LNLCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110038#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
reversible: true
is described by: ECO:0000000
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.12
fast: false
kinetic law: MODEL1310110038#
type: Reaction

metaR UMPK2n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
is: SBO:0000176
name: UMP kinase (CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaR FAOXC141C121m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaM odecrn m
is: C00412
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01114
constant: false
boundary condition: false
name: octadecenoyl carnitine
is: CHEBI:57394
has only substance units: false

metaM lnlnca c
name: alpha-linolenate
is: HMDB01388
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:32387
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_a1c72f81_da01_41f1_b4ad_a82212f7135f
initial amount: NaN
constant: false
name: COX8C
boundary condition: true
initial concentration: NaN
is: Q7Z4L0
is encoded by: hsa:341947
has only substance units: false
is: SBO:0000252
type: Species

metaR CITt4 2
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reactant: MODEL1310110038#
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110038#
name: citrate transport via sodium symport
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_855f1e2a_b50d_4b12_aff4_4993a133c868
is: SBO:0000252
type: Species
is encoded by: hsa:221
constant: false
initial amount: NaN
has only substance units: false
is: P43353
boundary condition: true
name: ALDH3B1
initial concentration: NaN

metaR PETOHMm hs
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reactant: MODEL1310110038#
is: SBO:0000176
is described by: ECO:0000254
fast: false
modifier: MODEL1310110038#
type: Reaction
name: phosphatidylethanolamine N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.17
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_483f917b_cdd8_4ce6_9ccb_ea1bdc09bb9c
initial concentration: NaN
is encoded by: hsa:5150
initial amount: NaN
name: PDE7A
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252

metaR G14T7g
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110038#
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR FADH2tx
product: MODEL1310110038#
is: SBO:0000185
name: FADH2 transporter, peroxisomal
kinetic law: MODEL1310110038#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110038#
fast: false
reversible: true

metaM 2dp6mobq me m
is: CHEBI:50772
notes: FORMULA: C58H88O3 CHARGE: 0 INCHI: InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+
boundary condition: false
name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_ee1d2f99_ede1_4c44_bc74_b835572daa75
type: Species
is: Q53Y41
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: DDC
is encoded by: hsa:1644
initial concentration: NaN
constant: false

metaM dhf c
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
has only substance units: false
initial amount: NaN
name: 7,8-Dihydrofolate
initial concentration: 1.0
is: HMDB01056
boundary condition: false
is: SBO:0000247
type: Species
is: C00415
constant: false

metaM man g
name: D-mannose
initial amount: NaN
type: Species
is: CHEBI:16024
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00169
constant: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

metaM imp c
initial concentration: 1.0
has only substance units: false
constant: false
is: C00130
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
name: IMP
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110038#_4a8a83e7_eedb_4508_b253_221f05017e9d
type: Species
initial concentration: NaN
name: PIGM
is encoded by: hsa:93183
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9H3S5
is: SBO:0000252

metaR DRBK
name: Deoxyribokinase
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.15
product: MODEL1310110038#
modifier: MODEL1310110038#
is: SBO:0000176
type: Reaction

metaM Nacasp c
name: N-acetyl-L-aspartate(2-)
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
is: HMDB00812
is: CHEBI:16953
is: SBO:0000247
boundary condition: false

metaM pi e
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
name: hydrogenphosphate
is: SBO:0000247
constant: false
is: CHEBI:43474
is: HMDB00973
initial concentration: 1.0
has only substance units: false
type: Species
is: C00009
initial amount: NaN

metaR PEAMNO
name: Phenethylamine oxidase
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
reactant: MODEL1310110038#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
fast: false
product: MODEL1310110038#
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.4

metaM nadh c
initial concentration: 1.0
has only substance units: false
type: Species
is: C00004
is: HMDB01487
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
constant: false

metaM HC01406 m
initial concentration: 1.0
boundary condition: false
is: CHEBI:28264
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
is: SBO:0000247
has only substance units: false
name: 3-Oxooctanoyl-CoA
initial amount: NaN
type: Species

metaR NDP7ex
is: SBO:0000176
kinetic law: MODEL1310110038#
product: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
type: Reaction
fast: false
name: nucleoside-diphosphatase (UDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110038#
reversible: false
is described by: ECO:0000269

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM ppa e
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
type: Species
is: HMDB00237
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: propionate

metaR GLNLASEer
name: gluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110038#
reversible: true
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
kinetic law: MODEL1310110038#
fast: false

metaR r1836
product: MODEL1310110038#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110038#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
reactant: MODEL1310110038#

metaM biocyt m
initial amount: NaN
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
is: SBO:0000247
is: C05552
is: http://identifiers.org/pubchem.compound/7886
type: Species
is: HMDB03134
initial concentration: 1.0
name: Biocytin
boundary condition: false

metaM sphmyln hs c
has only substance units: false
is: CHEBI:58216
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR r2532
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction

metaM akg x
is: HMDB00208
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
type: Species
boundary condition: false
initial amount: NaN
name: 2-oxoglutarate(2-)

metaM lnlnca e
is: HMDB01388
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
constant: false
is: SBO:0000247
is: CHEBI:32387
name: alpha-linolenate

metaR r1831
fast: false
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110038#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110038#
reactant: MODEL1310110038#
type: Reaction
reversible: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM gdp c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189
constant: false
initial amount: NaN
type: Species
is: HMDB01201
name: GDP
is: C00035
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_b6398c2b_a566_41dc_aaea_a730f17e41ed
is: SBO:0000252
constant: false
initial amount: NaN
name: PDE3B
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: Q13370
is encoded by: hsa:5140

metaM pi g
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: CHEBI:43474
boundary condition: false
name: hydrogenphosphate
type: Species
is: HMDB00973
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR RE0583C
fast: false
reactant: MODEL1310110038#
reversible: true
product: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
name: RE0583
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_2cc8a887_adbf_4de4_8532_d39d73ddfe46
is encoded by: hsa:8897
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: MTMR3
constant: false

metaM acrn m
boundary condition: false
is: CHEBI:57589
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: SBO:0000247
name: O-acetylcarnitine
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00201

metaM biocyt n
is: HMDB03134
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7886
type: Species
initial concentration: 1.0
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: C05552
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR FAOXC61C4x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaM spmd c
constant: false
name: Spermidine
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01257
type: Species
initial concentration: 1.0
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
is: C00315

metaM acgam1p c
is: HMDB01367
has only substance units: false
is: CHEBI:7125
initial concentration: 1.0
boundary condition: false
name: N-Acetyl-D-glucosamine 1-phosphate
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial amount: NaN
is: SBO:0000247
constant: false

metaM man e
initial concentration: 1.0
is: C00159
has only substance units: false
is: CHEBI:16024
initial amount: NaN
is: SBO:0000247
name: D-Mannose
boundary condition: false
type: Species
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false

metaM imp e
initial amount: NaN
name: IMP(2-)
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
is: SBO:0000247
constant: false

metaR r1830
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110038#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110038#
fast: false
is: SBO:0000185

metaM clpn hs c
is: CHEBI:21338
is: SBO:0000247
is: HMDB02704
boundary condition: false
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: clpn_hs[c]

http://identifiers.org/biomodels.db/MODEL1310110038#_9b1a67b1_1a12_4938_bb09_8af514aaef14
boundary condition: true
constant: false
has only substance units: false
name: PLCG1
initial amount: NaN
type: Species
is encoded by: hsa:5335
is: SBO:0000252
is: Q9UFY1
initial concentration: NaN

metaR FAOXC81C61m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_26a27e83_48d3_4f2b_a744_42a8c4df1ebc
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: P50053
name: KHK
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3795

metaM HC01412 m
name: trans-tetradec-2-enoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
constant: false
is: CHEBI:61405
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM oaa x
is: CHEBI:16452
initial amount: NaN
is: HMDB00223
name: Oxaloacetate
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
initial concentration: 1.0
is: C00036
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM hpdcacoa c
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
name: heptadecanoyl coa
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: HMDB06497
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_9414b1ff_6c5f_43f7_9c6d_544cd5409ac3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3418
is: P48735
initial amount: NaN
has only substance units: false
name: IDH2
type: Species
constant: false

metaM 56dura c
boundary condition: false
name: 5,6-dihydrouracil
initial concentration: 1.0
has only substance units: false
is: HMDB00076
is: SBO:0000247
constant: false
is: CHEBI:15901
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN

metaR MTHFR3
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
is described by: ECO:0000134
type: Reaction
fast: false
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.20
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_737ee2ab_f81e_4511_b377_2b5f382dba5a
type: Species
boundary condition: true
name: _AV713053_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AV713053
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_5f1284ad_4e8a_4363_9703_72f7a8af3e5a
name: RDH11
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:51109
type: Species
is: SBO:0000252
is: B4DDW0
boundary condition: true

metaR EX doco13ac
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR SFGTH
is version of: http://identifiers.org/ec-code/3.1.2.12
is: SBO:0000176
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
is described by: ECO:0000269
name: S-Formylglutathione hydralase
reactant: MODEL1310110038#
product: MODEL1310110038#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110038#

metaR FAOXC121x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM c8dc x
type: Species
is: SBO:0000247
is: HMDB00893
initial amount: NaN
has only substance units: false
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0
boundary condition: false
constant: false

metaM man c
is: HMDB00169
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: C00159
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
has only substance units: false
initial concentration: 1.0
name: D-Mannose
is: CHEBI:16024

metaM gdp e
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
has only substance units: false
is: CHEBI:58189
constant: false
initial amount: NaN
is: HMDB01201
type: Species
name: GDP(3-)
is: SBO:0000247
boundary condition: false

metaM glu L m
is: SBO:0000247
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
name: L-glutamate(1-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00148
has only substance units: false
is: CHEBI:29985

http://identifiers.org/biomodels.db/MODEL1310110038#_3b8fbd65_864e_432a_a55e_e77e9fd5a747
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:501
initial concentration: NaN
name: ALDH7A1
type: Species
is: SBO:0000252
is: E7EPT3

metaR O2St
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
reversible: true
kinetic law: MODEL1310110038#
name: superoxide anion transport via diffusion (extracellular)

metaR MANt4
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110038#
name: D-mannose transport via sodium cotransport
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110038#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110038#_e5af4597_df10_4bbd_9fba_2c845fd56e44
boundary condition: true
name: MBOAT7
initial amount: NaN
is: Q96N66
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:79143

http://identifiers.org/biomodels.db/MODEL1310110038#_7a3565dd_6dee_4931_be35_8b382cb4f747
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC2A9
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:56606

http://identifiers.org/biomodels.db/MODEL1310110038#_4362fe43_eb08_43af_bf42_3a3863dbe52e
is: P19174
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5335
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: PLCG1
initial concentration: NaN

metaR BHBtm
fast: false
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is described by: ECO:0000000
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_9d5d05ef_435e_47dd_8d02_5f2d00e4d54a
name: ATP2B4
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:493
is: P23634
has only substance units: false
constant: false

metaM hx2coa m
name: trans-Hex-2-enoyl-CoA
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C05998
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaM hdcoa c
initial amount: NaN
is: HMDB06532
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
name: Hexadecenoyl-CoA (n-C16:1CoA)

metaM HC01434 c
has only substance units: false
name: oxalatosuccinate(3-)
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
is: CHEBI:58931

http://identifiers.org/biomodels.db/MODEL1310110038#_9e87ae9b_493d_4cff_bc58_03660c65eb64
constant: false
name: ALDH3A1
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:218
is: P30838
is: SBO:0000252
has only substance units: false

metaR r1167
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
reversible: false
name: EC:2.3.1.26

metaM pmtcoa r
is: CHEBI:3454
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: HMDB01338
initial concentration: 1.0
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaM sphmyln hs g
name: sphingomyelin betaine
is: CHEBI:58216
initial amount: NaN
type: Species
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_8a624acb_c16e_4542_8f3b_f7d21c5fee48
initial concentration: NaN
boundary condition: true
constant: false
is: Q9UIG8
is: SBO:0000252
is encoded by: hsa:28232
initial amount: NaN
has only substance units: false
name: SLCO3A1
type: Species

metaM ha pre1 e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
constant: false
name: hyaluronan biosynthesis, precursor 1
is: CHEBI:16126

metaR FUCASEe
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110038#
name: alpha-fucosidase, extracellular

metaM xyl D c
type: Species
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
name: aldehydo-D-xylose
initial amount: NaN
is: CHEBI:15936
boundary condition: false
has only substance units: false
constant: false

metaM c12dc c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false
is: HMDB00623
type: Species
initial amount: NaN
boundary condition: false
name: dodecanedioyl carnitine
initial concentration: 1.0

metaR DHAAt1r
type: Reaction
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
product: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000269
name: dehydroascorbate transport (uniport)

metaM pi r
has only substance units: false
is: CHEBI:43474
is: C00009
initial amount: NaN
is: HMDB00973
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
type: Species
is: SBO:0000247
name: hydrogenphosphate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_6840f26f_7f70_46dc_a99a_d72247fd5967
boundary condition: true
initial concentration: NaN
is: Q06830
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: PRDX1
is encoded by: hsa:5052

http://identifiers.org/biomodels.db/MODEL1310110038#_2bacb6e4_0fe4_40cf_b9c9_7e42b79e0861
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10400
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9UBM1
name: PEMT

metaM itp n
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
initial concentration: 1.0
type: Species
constant: false
is: HMDB00189
boundary condition: false
is: SBO:0000247
is: CHEBI:57614
initial amount: NaN
has only substance units: false

metaM acgam r
name: N-acetyl-D-glucosamine
is: HMDB00215
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411

http://identifiers.org/biomodels.db/MODEL1310110038#_0cc1d1fe_6c73_4b2a_abc1_e2d240f2f2f0
constant: false
boundary condition: true
is encoded by: hsa:9963
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC23A1

metaR CHSTEROLt2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
type: Reaction
reactant: MODEL1310110038#
name: cholesterol intracellular transport
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185

metaR r2384
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110038#
is: SBO:0000185
product: MODEL1310110038#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM tdec4ecoa m
is: C08277
is: HMDB00792
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
constant: false
type: Species
has only substance units: false
name: trans4decenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_7f4dd8ff_8920_4ba7_b204_12e1b4792147
constant: false
boundary condition: true
name: NDUFA7
is: Q6FG42
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4701

http://identifiers.org/biomodels.db/MODEL1310110038#_feb42ab2_9799_4aa5_a029_09e1de17ac88
type: Species
constant: false
is: Q8N9L9
has only substance units: false
initial concentration: NaN
name: ACOT4
is encoded by: hsa:122970
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR AATAi
name: 2-aminoadipate transaminase, irreversible
type: Reaction
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
reversible: false
kinetic law: MODEL1310110038#
is described by: ECO:0000269
reactant: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false

metaR r0202
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110038#_5a433248_76ec_405d_8bf4_5e0f0b725512
is: P09960
name: LTA4H
boundary condition: true
is encoded by: hsa:4048
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110038#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110038#
kinetic law: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR G6PPer
name: glucose-6-phosphate phosphatase, edoplasmic reticular
is version of: http://identifiers.org/ec-code/3.1.3.9
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
is: SBO:0000176
product: MODEL1310110038#
reversible: false
type: Reaction
reactant: MODEL1310110038#
fast: false

metaR G5SDym
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.41
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
reversible: false
product: MODEL1310110038#
name: glutamate-5-semialdehyde dehydrogenase (m)
reactant: MODEL1310110038#

metaM HC02205 c
constant: false
has only substance units: false
name: prostaglandin-b2
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
boundary condition: false
is: CHEBI:28099
type: Species

metaM accoa r
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
name: acetyl-CoA(4-)
type: Species
boundary condition: false
is: HMDB01206
is: CHEBI:57288
constant: false
initial concentration: 1.0
initial amount: NaN

metaM HC01610 e
name: CoproporphyrinogenI
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:28607
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768

metaR CHSTEROLt3
reactant: MODEL1310110038#
fast: false
product: MODEL1310110038#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110038#
name: cholesterol intracellular transport
is described by: ECO:0000000
reversible: true
type: Reaction

metaR LSTO2r
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
kinetic law: MODEL1310110038#
name: Lathosterol oxidase
reactant: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/1.14.21.6
product: MODEL1310110038#
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110038#_3de291a3_5a30_4e20_9088_fb166c525fae
initial amount: NaN
is: P18859
has only substance units: false
is encoded by: hsa:522
is: SBO:0000252
name: ATP5J
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaR DURIK1
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
name: deoxyuridine kinase (ATP:Deoxyuridine)
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:

metaR FACOAL2251
reversible: true
type: Reaction
modifier: MODEL1310110038#
name: fatty-acid--CoA ligase
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110038#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000000

metaM xyl D e
type: Species
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
name: aldehydo-D-xylose
is: CHEBI:15936
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_1592b71b_c996_4425_9fee_677c031529ec
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:6534
initial concentration: NaN
constant: false
is: Q99884
name: SLC6A7
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_22008afb_0411_47a3_8e95_6950ef437d9b
is encoded by: hsa:64902
name: AGXT2
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: Q9BYV1
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r0354
product: MODEL1310110038#
reactant: MODEL1310110038#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is described by: ECO:0000000

metaM 6dhf e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
constant: false
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
boundary condition: false
is: HMDB06563

metaR RE3244R
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110038#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
is: SBO:0000176
name: RE3244
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_ae441c8f_4c23_481d_a245_49f7b4178206
has part: A8K092
is: SBO:0000297
has only substance units: false
type: Species
has part: P30049
has part: P06576
is encoded by: hsa:506
boundary condition: true
has part: P56381
is encoded by: hsa:514
initial amount: NaN
is encoded by: hsa:498
is encoded by: hsa:513
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
constant: false
is encoded by: hsa:509
has part: P36542

http://identifiers.org/biomodels.db/MODEL1310110038#_c3a35a65_0977_4a3f_8bef_850cca72aa76
boundary condition: true
is encoded by: hsa:5464
constant: false
type: Species
initial amount: NaN
name: PPA1
is: Q15181
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: C00015
is: HMDB00295
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: UDP
constant: false
has only substance units: false
is: CHEBI:58223
initial concentration: 1.0

metaR LALDO2x
type: Reaction
product: MODEL1310110038#
fast: false
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
reversible: false
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000269
is: SBO:0000176
name: D-Lactaldehyde:NAD+ 1-oxidoreductase

metaM Lcystin e
is: HMDB00192
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
is: SBO:0000247
initial amount: NaN
name: L-cystine
is: CHEBI:16283
has only substance units: false
type: Species

metaM dec24dicoa m
initial concentration: 1.0
name: 2,4-decadienoylcoa
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB01168
has only substance units: false
boundary condition: false

metaR M4MPDOL Uter
kinetic law: MODEL1310110038#
name: m4mpdol flippase
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110038#
is: SBO:0000185

metaR r2382
reversible: false
kinetic law: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110038#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110038#

metaR SUBEACTD
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR PRISTANALtx
type: Reaction
fast: false
reactant: MODEL1310110038#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is: SBO:0000185
name: pristanal peroxisomal transport
reversible: true
kinetic law: MODEL1310110038#
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_b6afe3b1_ea3d_49c4_a9b1_23e6c6253287
name: ST3GAL3
is: SBO:0000252
is encoded by: hsa:6487
is: Q5T4Y1
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110038#_57592228_a4d6_4ee5_b08b_0647783f9ad6
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: ATP5J
constant: false
is encoded by: hsa:522
is: SBO:0000252
type: Species

metaM HC02205 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
type: Species
constant: false
initial amount: NaN
is: CHEBI:28099
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110038#_8e340e78_25c1_4a3d_a4c9_72aa812b67ae
type: Species
is encoded by: hsa:56922
has part: Q9HCC0
name: MCCC1:MCCC2
initial concentration: NaN
initial amount: NaN
has part: Q96RQ3
constant: false
has only substance units: false
is encoded by: hsa:64087
boundary condition: true
is: SBO:0000297

metaR CYTK13n
is: SBO:0000176
type: Reaction
modifier: MODEL1310110038#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110038#
name: cytidylate kinase (dCMP,dATP),nuclear
fast: false
is described by: ECO:0000269
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_d127a1a8_2698_49cd_94af_c76603801b78
name: HPD
is: SBO:0000252
is encoded by: hsa:3242
type: Species
initial concentration: NaN
is: B3KQ63
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaM retinal r
constant: false
type: Species
has only substance units: false
is: HMDB01358
boundary condition: false
is: SBO:0000247
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
initial amount: NaN
is: CHEBI:15035
initial concentration: 1.0

metaM 2mp2coa m
is: CHEBI:27754
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01011
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110038#_81303eae_7495_4845_a454_466a74ca2c81
is: Q99798
is encoded by: hsa:50
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
name: ACO2
boundary condition: true
has only substance units: false
type: Species

metaR CHSTEROLt1
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110038#
name: cholesterol intracellular transport
is described by: ECO:0000304
modifier: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?

http://identifiers.org/biomodels.db/MODEL1310110038#_af639839_4c13_425d_92d0_2fbca977a040
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: B4DK61
constant: false
is encoded by: hsa:51
type: Species
name: ACOX1

http://identifiers.org/biomodels.db/MODEL1310110038#_a9616189_2989_45de_95c2_92b76c096d97
is encoded by: hsa:6611
is: SBO:0000252
type: Species
is: P52788
has only substance units: false
boundary condition: true
name: SMS
initial amount: NaN
constant: false
initial concentration: NaN

metaM CE5132 c
initial amount: NaN
constant: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
is: CHEBI:57923
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_0a874496_1413_4b03_9ec6_e2927657ee94
is: Q9H0I9
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84076
name: TKTL2
constant: false
type: Species
initial concentration: NaN

metaM pi n
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:43474
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
name: hydrogenphosphate
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110038#_bd503606_6a88_429a_b582_8b8d145929b0
is encoded by: hsa:9963
name: SLC23A1
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9UHI7
is: SBO:0000252
has only substance units: false

metaR r2380
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110038#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110038#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110038#_feb433a2_5f57_4c7a_97a2_3cf1ab7d064c
type: Species
is encoded by: hsa:476
initial amount: NaN
is: B7Z3U6
has only substance units: false
initial concentration: NaN
name: ATP1A1
constant: false
boundary condition: true
is: SBO:0000252

metaM lnlncacrn m
is: SBO:0000247
name: alpha-linolenyl carnitine
is: HMDB06319
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1

metaM tchola c
is: SBO:0000247
boundary condition: false
is: CHEBI:36257
name: taurocholic acid
initial amount: NaN
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00036

metaR PA HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110038#
name: phosphatidate transport, nuclear
type: Reaction

metaM 5aizc c
initial concentration: 1.0
is: CHEBI:58564
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: HMDB06273
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
type: Species
is: C04751

metaR TRDR
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
reactant: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
name: thioredoxin reductase (NADPH)
fast: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176
product: MODEL1310110038#
is described by: ECO:0000269
kinetic law: MODEL1310110038#

metaR DNDPt15m
name: dUDP transport via dGDP antiport
type: Reaction
reactant: MODEL1310110038#
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
product: MODEL1310110038#
is: SBO:0000185
kinetic law: MODEL1310110038#
fast: false

metaM k c
initial amount: NaN
is: HMDB00586
is: SBO:0000247
has only substance units: false
type: Species
is: C00238
boundary condition: false
name: potassium
is: CHEBI:29103
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0

metaM cs e deg5 l
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00868
is: CHEBI:57737
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H47NO35S3 CHARGE: -4
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
boundary condition: false

metaM pi m
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
constant: false
name: hydrogenphosphate
is: SBO:0000247
is: HMDB00973
boundary condition: false
type: Species
is: C00009
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_ea36893f_8d4f_4e99_8f9a_a8e3e329ab62
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:8050
initial concentration: NaN
name: PDHX
has only substance units: false
is: O00330
boundary condition: true

metaR GTHP
reversible: true
is: SBO:0000176
name: glutathione peroxidase
modifier: MODEL1310110038#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110038#
fast: false
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_e59e81d0_0233_4898_9ffa_bd180adfdc12
is encoded by: hsa:1345
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: COX6C
initial amount: NaN
is: P09669
is: SBO:0000252
type: Species

metaR FACOAL161
product: MODEL1310110038#
fast: false
reactant: MODEL1310110038#
name: fatty-acid--CoA ligase (hexadecenoate)
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110038#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110038#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110038#_52ae5eac_e526_4faa_9f01_257f8868eefa
type: Species
is: E5KS60
boundary condition: true
is encoded by: hsa:8803
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
name: SUCLA2

metaR DUMPtn
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110038#
kinetic law: MODEL1310110038#
name: dUMP nuclear transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110038#
type: Reaction

metaR SGPL12r
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ

metaR r1874
product: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110038#
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110038#
name: Y+LAT2 Utilized transport

metaM pail45p hs c
type: Species
boundary condition: false
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
is: CHEBI:28910

metaM cdpdag hs c
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false
name: CDP-diacylglycerol(2-)
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110038#_83f6330b_7131_4bc5_a1fa_47620488d3da
is encoded by: hsa:56953
boundary condition: true
is: SBO:0000252
name: NT5M
initial amount: NaN
constant: false
type: Species
is: Q9NPB1
initial concentration: NaN
has only substance units: false

metaM mn l
type: Species
has only substance units: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
initial amount: NaN
constant: false
is: HMDB06535
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM pi l
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: hydrogenphosphate
boundary condition: false
is: CHEBI:43474
has only substance units: false
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_79e756e9_074f_4ead_a5d2_c9a9b375c99b
name: SLC5A12
has only substance units: false
type: Species
is: Q1EHB4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:159963
initial amount: NaN

metaM 3hexdtetcoa m
is: HMDB02288
boundary condition: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
constant: false
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
initial concentration: 1.0

metaR MTHFD
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
modifier: MODEL1310110038#
product: MODEL1310110038#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methylenetetrahydrofolate dehydrogenase (NADP)

metaM ksii core2 pre1 g
notes: FORMULA: C33H53N3O23X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 1
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:28067
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaR FAOXC164x
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR GTHO
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110038#
product: MODEL1310110038#
reversible: false
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
is: SBO:0000176
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110038#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110038#_2d93cfec_6c7b_47dd_846b_984adf41c802
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: _AI222095_1_m
initial amount: NaN
is encoded by: hsa:AI222095
has only substance units: false
initial concentration: NaN

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB06537

metaR 34DHOXPEGOX
fast: false
type: Reaction
kinetic law: MODEL1310110038#
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110038#
name: 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (130.1) or (127.1) or (125.1 and 124.1) or (131.1) or (126.1 and 124.1) or (128.1) or (137872.1) or (125.1 and 126.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.1.1.1 Confidence Level: 4 AUTHORS: PMID:3466164 NOTES:SAB
reversible: true
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.24
reactant: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_579febc9_f72a_4e77_b5ac_d7a1bda95645
name: PTDSS1
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:9791
initial amount: NaN
is: P48651
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110038#_e2302c38_492f_44c8_9e2c_50cf4e5c1a53
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
has part: Q6NZ59
boundary condition: true
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:522

metaM spc hs e
has only substance units: false
name: sphingosylphosphorylcholine
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
type: Species

metaR FATP1t
product: MODEL1310110038#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110038#
type: Reaction
reactant: MODEL1310110038#
name: fatty acid electroneutral transport
is described by: ECO:0000269
fast: false
modifier: MODEL1310110038#

metaM sbcoa x
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM tchola e
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0
constant: false
name: taurocholic acid
type: Species
initial concentration: 1.0
is: HMDB00036
is: SBO:0000247

metaR AG13T12g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110038#
reactant: MODEL1310110038#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#

metaM tyr L m
has only substance units: false
boundary condition: false
is: CHEBI:17895
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00158
constant: false
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species

metaR MTHFC
modifier: MODEL1310110038#
name: methenyltetrahydrofolate cyclohydrolase
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
fast: false
reversible: true
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
is: SBO:0000176

metaM accoa x
name: Acetyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00024
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
is: SBO:0000247
has only substance units: false
is: CHEBI:57288
type: Species

http://identifiers.org/biomodels.db/MODEL1310110038#_1182f422_28ce_4101_86c7_58f7c98847a5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:27068
constant: false
boundary condition: true
name: PPA2
initial amount: NaN
initial concentration: NaN
type: Species

metaM phyt2ohcoa x
has only substance units: false
is: HMDB01295
initial concentration: 1.0
is: CHEBI:57334
is: SBO:0000247
name: 2-hydroxyphytanoyl-CoA(4-)
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
constant: false
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110038#_3b0e15f6_9e9d_47f2_bbab_98fbcb99ce52
is: O75489
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4722
name: NDUFS3
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110038#_1c8e8997_5e4c_405d_820e_f6cec10f0859
name: GCNT1
initial amount: NaN
is: Q02742
is: SBO:0000252
is encoded by: hsa:2650
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110038#_4155051c_68b7_4f8e_89cb_fcd98573cb9c
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _AA526438_1_c
constant: false
has only substance units: false
is encoded by: hsa:AA526438
is: SBO:0000252
type: Species

metaR ASPTA
product: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.6.1.1
name: aspartate transaminase
kinetic law: MODEL1310110038#
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction

metaR MTHFD2
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is: SBO:0000176
fast: false
name: methylenetetrahydrofolate dehydrogenase (NAD)
kinetic law: MODEL1310110038#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
product: MODEL1310110038#

metaM dece4coa m
initial concentration: 1.0
constant: false
name: 4-decenoylcoa
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02145
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR FAOXC1811603m
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110038#
product: MODEL1310110038#
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation fatty acid
is: SBO:0000176
type: Reaction
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269

metaR C204CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reactant: MODEL1310110038#
product: MODEL1310110038#
type: Reaction
reversible: false
name: arachidonic acid transport into the mitochondria
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110038#
is: SBO:0000185

metaM 5htrp c
initial concentration: 1.0
is: HMDB00472
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
name: 5-hydroxy-L-tryptophan
initial amount: NaN
is: CHEBI:17780

http://identifiers.org/biomodels.db/MODEL1310110038#_5b40030b_bede_4dbe_81ce_2de90f4320dd
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: O95622
is: SBO:0000252
has only substance units: false
name: ADCY5
boundary condition: true
is encoded by: hsa:111

metaR TETDEC2CRNe
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR DNDPt26m
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110038#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110038#
is described by: ECO:0000269
modifier: MODEL1310110038#
reactant: MODEL1310110038#
name: dCDP transport via dUDP antiport
fast: false

metaR HYXNt
modifier: MODEL1310110038#
reactant: MODEL1310110038#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
is described by: ECO:0000269
name: Hypoxanthine transport
kinetic law: MODEL1310110038#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110038#

metaR r1591
reversible: true
reactant: MODEL1310110038#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110038#

metaR FAOXC103C102m
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM leuktrB4 c
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: leukotriene B4(1-)
initial amount: NaN
is: HMDB01085
type: Species
has only substance units: false

metaM adrncrn m
is: C00318
notes: FORMULA: C29H49NO4 CHARGE: 0
is: HMDB00062
initial amount: NaN
boundary condition: false
name: Adrenyl carnitine
has only substance units: false
constant: false
is: CHEBI:16347
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM lald D c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: SBO:0000247
boundary condition: false
is: CHEBI:17167
initial amount: NaN
type: Species
constant: false
is: HMDB06458
name: (R)-lactaldehyde
initial concentration: 1.0
has only substance units: false

metaM dcyt c
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
type: Species
is: CHEBI:15698
initial concentration: 1.0
is: HMDB00014
boundary condition: false

metaR DGCHOLte
fast: false
reversible: true
name: bile acid intracellular transport
reactant: MODEL1310110038#
kinetic law: MODEL1310110038#
product: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR CSNAT2x
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
product: MODEL1310110038#
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.137
fast: false
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/2.3.1.7

metaR ACACT10m
is described by: ECO:0000134
reversible: true
modifier: MODEL1310110038#
reactant: MODEL1310110038#
is: SBO:0000176
kinetic law: MODEL1310110038#
product: MODEL1310110038#
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false

metaM nadh x
has only substance units: false
is: SBO:0000247
is: HMDB01487
type: Species
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
constant: false
boundary condition: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945

metaR NTD1
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110038#
modifier: MODEL1310110038#
reversible: false
kinetic law: MODEL1310110038#
reactant: MODEL1310110038#
name: 5'-nucleotidase (dUMP)
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110038#_55959c98_5465_4294_986a_b7b1cac07f96
initial concentration: NaN
has part: P27986
has only substance units: false
boundary condition: true
is encoded by: hsa:5295
initial amount: NaN
name: PIK3CA:PIK3R1
constant: false
is: SBO:0000297
type: Species

metaR 34DHXMANDACOX NADP
type: Reaction
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
kinetic law: MODEL1310110038#
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
product: MODEL1310110038#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110038#
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110038#
is: SBO:0000176

metaR r1592
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110038#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110038#
reversible: true
is: SBO:0000185
reactant: MODEL1310110038#

metaR MM5ag
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110038#
is described by: ECO:0000000
product: MODEL1310110038#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110038#
fast: false
modifier: MODEL1310110038#
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
type: Reaction

metaR r2519
reactant: MODEL1310110038#
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
fast: false
kinetic law: MODEL1310110038#
reversible: true
product: MODEL1310110038#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM 5pmev x
boundary condition: false
is: SBO:0000247
is: HMDB01343
initial amount: NaN
is: CHEBI:58146
name: (R)-5-phosphonatomevalonate(3-)
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR GALSIDEtg
is: SBO:0000185
reactant: MODEL1310110038#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110038#
is described by: ECO:0000000
name: galactocerebroside intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
product: MODEL1310110038#

http://identifiers.org/biomodels.db/MODEL1310110038#_407dc335_401d_4f3a_ad05_0c63ddefe57a
has part: F8W7V3
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:517

metaR ADPCOACROT
kinetic law: MODEL1310110038#
product: MODEL1310110038#
reactant: MODEL1310110038#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR PI5P4K
product: MODEL1310110038#
reversible: false
modifier: MODEL1310110038#
kinetic law: MODEL1310110038#
is: SBO:0000176
reactant: MODEL1310110038#
type: Reaction
fast: false
name: phosphatidylinositol-5-phosphate 4-kinase
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.67
is described by: ECO:0000000

metaR r1593
reactant: MODEL1310110038#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110038#
product: MODEL1310110038#

metaM acgam l
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
initial concentration: 1.0
is: CHEBI:17411
name: N-acetyl-D-glucosamine
is: HMDB00215
is: SBO:0000247

metaM pi x
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: hydrogenphosphate
is: CHEBI:43474